Mus musculus

191 known processes

Lck

lymphocyte protein tyrosine kinase

(Aliases: Lskt,p56<lck>,Lsk,p56Lck,Hck-3)

Lck biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
positive regulation of gamma delta t cell differentiation GO:0045588 6 0.999
t cell receptor signaling pathway GO:0050852 46 0.993
t cell differentiation GO:0030217 174 0.992
leukocyte differentiation GO:0002521 342 0.991
t cell differentiation in thymus GO:0033077 77 0.990
positive regulation of t cell activation GO:0050870 101 0.990
lymphocyte differentiation GO:0030098 242 0.989
regulation of lymphocyte activation GO:0051249 240 0.983
antigen receptor mediated signaling pathway GO:0050851 64 0.983
positive regulation of t cell mediated cytotoxicity GO:0001916 15 0.981
regulation of cell activation GO:0050865 289 0.975
positive t cell selection GO:0043368 23 0.974
platelet degranulation GO:0002576 6 0.967
Mouse
positive regulation of lymphocyte activation GO:0051251 140 0.956
t cell activation GO:0042110 289 0.947
regulation of t cell mediated cytotoxicity GO:0001914 18 0.932
t cell selection GO:0045058 34 0.916
cellular amino acid metabolic process GO:0006520 103 0.914
regulation of platelet activation GO:0010543 17 0.910
Mouse
immune response activating cell surface receptor signaling pathway GO:0002429 72 0.909
regulation of leukocyte differentiation GO:1902105 159 0.906
negative regulation of t cell mediated cytotoxicity GO:0001915 3 0.905
positive regulation of regulatory t cell differentiation GO:0045591 4 0.893
positive regulation of leukocyte differentiation GO:1902107 86 0.892
hematopoietic stem cell migration GO:0035701 1 0.888
thymic t cell selection GO:0045061 22 0.868
leukocyte apoptotic process GO:0071887 71 0.861
Mouse
positive regulation of lymphocyte differentiation GO:0045621 61 0.860
gamma delta t cell activation GO:0046629 13 0.857
amine metabolic process GO:0009308 45 0.851
positive regulation of cell activation GO:0050867 158 0.837
regulation of t cell differentiation GO:0045580 83 0.829
cellular amine metabolic process GO:0044106 44 0.828
regulation of t cell anergy GO:0002667 4 0.823
fc receptor mediated stimulatory signaling pathway GO:0002431 4 0.813
Mouse
myeloid cell homeostasis GO:0002262 114 0.808
Mouse
negative thymic t cell selection GO:0045060 12 0.802
extrinsic apoptotic signaling pathway GO:0097191 126 0.801
positive thymic t cell selection GO:0045059 13 0.799
regulation of cellular amine metabolic process GO:0033238 20 0.792
regulation of leukocyte apoptotic process GO:2000106 56 0.787
Mouse
peptidyl tyrosine modification GO:0018212 145 0.781
serotonin secretion involved in inflammatory response GO:0002442 4 0.776
positive regulation of b cell activation GO:0050871 49 0.770
cellular ketone metabolic process GO:0042180 84 0.768
peptidyl tyrosine phosphorylation GO:0018108 143 0.766
positive regulation of antigen receptor mediated signaling pathway GO:0050857 9 0.747
Mouse
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.742
defense response to other organism GO:0098542 197 0.739
Mouse
cd4 positive cd25 positive alpha beta regulatory t cell differentiation GO:0002361 4 0.738
immune response activating signal transduction GO:0002757 116 0.734
t cell mediated cytotoxicity GO:0001913 26 0.729
regulation of lymphocyte anergy GO:0002911 4 0.725
positive regulation of cell killing GO:0031343 33 0.725
tyrosine phosphorylation of stat5 protein GO:0042506 9 0.722
neutrophil activation involved in immune response GO:0002283 8 0.720
regulation of t cell activation GO:0050863 170 0.713
regulation of peptidyl tyrosine phosphorylation GO:0050730 93 0.712
apoptotic signaling pathway GO:0097190 306 0.675
Human
regulation of cellular amino acid metabolic process GO:0006521 5 0.663
positive regulation of gamma delta t cell activation GO:0046645 6 0.653
immune effector process GO:0002252 321 0.640
Mouse
t cell proliferation GO:0042098 120 0.636
Mouse
interleukin 2 mediated signaling pathway GO:0038110 2 0.626
peptidyl amino acid modification GO:0018193 336 0.616
gamma delta t cell differentiation GO:0042492 11 0.600
positive regulation of cellular amine metabolic process GO:0033240 5 0.600
small gtpase mediated signal transduction GO:0007264 97 0.600
lymphocyte mediated immunity GO:0002449 139 0.599
leukocyte homeostasis GO:0001776 79 0.589
Mouse
positive regulation of immune effector process GO:0002699 107 0.577
Mouse
positive regulation of calcium mediated signaling GO:0050850 15 0.531
positive regulation of t cell proliferation GO:0042102 52 0.526
positive regulation of leukocyte mediated immunity GO:0002705 70 0.518
Mouse
regulation of alpha beta t cell differentiation GO:0046637 35 0.516
plasma membrane organization GO:0007009 90 0.515
leukocyte cell cell adhesion GO:0007159 14 0.513
alpha beta t cell activation GO:0046631 91 0.512
Mouse
regulation of transferase activity GO:0051338 263 0.509
Mouse Fly
exocytosis GO:0006887 121 0.507
Mouse
somatic recombination of immunoglobulin gene segments GO:0016447 42 0.506
serotonin secretion by platelet GO:0002554 3 0.497
negative regulation of homeostatic process GO:0032845 71 0.489
regulation of b cell differentiation GO:0045577 23 0.487
adaptive immune response GO:0002250 155 0.477
Mouse
regulation of cellular ketone metabolic process GO:0010565 66 0.460
defense response to virus GO:0051607 68 0.456
negative regulation of cell adhesion involved in substrate bound cell migration GO:0006933 3 0.453
regulation of lymphocyte differentiation GO:0045619 107 0.450
positive regulation of type iii hypersensitivity GO:0001805 3 0.449
cytokine production GO:0001816 319 0.425
Mouse
cytokine mediated signaling pathway GO:0019221 115 0.421
actin filament organization GO:0007015 113 0.418
Fly
regulation of leukocyte mediated cytotoxicity GO:0001910 38 0.418
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 61 0.416
cellular response to interleukin 15 GO:0071350 2 0.416
alpha beta t cell proliferation GO:0046633 21 0.408
somatic diversification of immune receptors GO:0002200 53 0.405
positive regulation of hematopoietic stem cell migration GO:2000473 1 0.402
regulation of gamma delta t cell differentiation GO:0045586 9 0.396
gland development GO:0048732 330 0.393
Mouse Fly
regulation of protein kinase activity GO:0045859 232 0.388
Mouse Fly
neutrophil activation GO:0042119 9 0.386
leukocyte proliferation GO:0070661 172 0.383
Mouse
regulation of alpha beta t cell proliferation GO:0046640 18 0.383
regulation of alpha beta t cell activation GO:0046634 53 0.378
positive regulation of lymphocyte proliferation GO:0050671 70 0.378
regulation of homotypic cell cell adhesion GO:0034110 13 0.377
Mouse
regulation of toll like receptor 4 signaling pathway GO:0034143 4 0.372
Mouse
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 55 0.372
positive regulation of protein modification process GO:0031401 299 0.369
apical constriction GO:0003383 4 0.356
regulation of natural killer cell activation GO:0032814 22 0.350
leukocyte mediated immunity GO:0002443 174 0.347
Mouse
tyrosine phosphorylation of stat protein GO:0007260 23 0.346
endodermal cell fate specification GO:0001714 4 0.341
Worm
regulation of defense response GO:0031347 233 0.340
Mouse
regulation of map kinase activity GO:0043405 120 0.339
Mouse
regulation of type iia hypersensitivity GO:0001796 4 0.336
positive regulation of protein phosphorylation GO:0001934 242 0.329
regulation of phagocytosis GO:0050764 33 0.328
Mouse
positive regulation of t cell differentiation GO:0045582 52 0.323
negative t cell selection GO:0043383 13 0.321
regulation of cell killing GO:0031341 40 0.314
positive regulation of cell death GO:0010942 224 0.313
Human Mouse
positive regulation of protein kinase activity GO:0045860 144 0.310
Fly
antigen processing and presentation of peptide antigen via mhc class i GO:0002474 9 0.310
positive regulation of kinase activity GO:0033674 155 0.296
Mouse Fly
second messenger mediated signaling GO:0019932 73 0.292
homeostasis of number of cells GO:0048872 210 0.290
Mouse
regulation of cell migration GO:0030334 219 0.289
Mouse
regulation of apoptotic signaling pathway GO:2001233 197 0.288
Human
positive regulation of leukocyte mediated cytotoxicity GO:0001912 31 0.287
regulation of lymphocyte apoptotic process GO:0070228 41 0.282
Mouse
serotonin production involved in inflammatory response GO:0002351 4 0.281
somatic cell dna recombination GO:0016444 51 0.281
negative regulation of insulin receptor signaling pathway GO:0046627 14 0.274
bone marrow development GO:0048539 3 0.273
cell fate commitment GO:0045165 210 0.272
Worm
modulation by virus of host process GO:0019054 2 0.272
divalent inorganic cation transport GO:0072511 178 0.271
lymphocyte anergy GO:0002249 4 0.271
positive regulation of type ii hypersensitivity GO:0002894 4 0.268
regulation of adaptive immune response GO:0002819 90 0.267
regulation of homeostatic process GO:0032844 182 0.266
lymphocyte apoptotic process GO:0070227 54 0.266
Mouse
protein localization to plasma membrane GO:0072659 57 0.264
granulocyte activation GO:0036230 10 0.263
protein localization to nucleus GO:0034504 121 0.263
Mouse
somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 51 0.259
lymphocyte homeostasis GO:0002260 64 0.258
Mouse
t cell anergy GO:0002870 4 0.254
protein localization to membrane GO:0072657 108 0.251
regulation of mast cell activation GO:0033003 21 0.251
Mouse
regulation of kinase activity GO:0043549 249 0.248
Mouse Fly
single organismal cell cell adhesion GO:0016337 131 0.247
Mouse Fly
leukocyte activation involved in immune response GO:0002366 126 0.246
Mouse
antigen processing and presentation of exogenous peptide antigen GO:0002478 21 0.243
positive regulation of defense response GO:0031349 124 0.240
Mouse
positive regulation of stress activated mapk cascade GO:0032874 48 0.240
regulation of dendritic cell apoptotic process GO:2000668 3 0.238
Mouse
positive regulation of podosome assembly GO:0071803 3 0.237
Mouse
signal transduction in absence of ligand GO:0038034 55 0.236
protein autophosphorylation GO:0046777 61 0.236
regulation of endocytosis GO:0030100 69 0.235
Mouse
blood coagulation GO:0007596 76 0.234
Mouse
regulation of t cell proliferation GO:0042129 92 0.233
calcium mediated signaling GO:0019722 46 0.230
protein import GO:0017038 101 0.229
canonical wnt signaling pathway GO:0060070 130 0.223
Mouse
b cell proliferation GO:0042100 53 0.223
Mouse
fc receptor mediated inhibitory signaling pathway GO:0002774 1 0.223
Mouse
protein localization to organelle GO:0033365 185 0.218
Mouse
integrin mediated signaling pathway GO:0007229 27 0.216
Mouse
cytoplasmic transport GO:0016482 234 0.214
negative regulation of myeloid leukocyte differentiation GO:0002762 20 0.212
Mouse
regulation of calcium mediated signaling GO:0050848 19 0.202
activation of immune response GO:0002253 138 0.201
membrane organization GO:0061024 245 0.198
regulation of interferon gamma production GO:0032649 57 0.191
regulation of cytokine production GO:0001817 266 0.189
Mouse
positive regulation of mast cell activation involved in immune response GO:0033008 10 0.188
Mouse
response to organonitrogen compound GO:0010243 246 0.186
positive regulation of transferase activity GO:0051347 167 0.186
Mouse Fly
regulation of leukocyte proliferation GO:0070663 121 0.183
Mouse
myeloid leukocyte differentiation GO:0002573 119 0.183
Mouse
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.180
organelle localization GO:0051640 179 0.180
Mouse Worm
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.179
leukocyte degranulation GO:0043299 27 0.179
Mouse
regulation of secretion by cell GO:1903530 249 0.168
Mouse
regulation of tyrosine phosphorylation of stat5 protein GO:0042522 8 0.167
immune response inhibiting cell surface receptor signaling pathway GO:0002767 3 0.166
Mouse
activation of phospholipase c activity GO:0007202 2 0.165
Mouse
cell adhesion GO:0007155 329 0.164
Mouse Fly
negative regulation of peptidyl tyrosine phosphorylation GO:0050732 17 0.153
endomembrane system organization GO:0010256 147 0.152
fc epsilon receptor signaling pathway GO:0038095 3 0.149
b cell differentiation GO:0030183 78 0.148
nitrogen compound transport GO:0071705 271 0.145
regulation of intracellular transport GO:0032386 159 0.144
Mouse
nuclear transport GO:0051169 139 0.144
regulation of regulatory t cell differentiation GO:0045589 7 0.144
inflammatory response to antigenic stimulus GO:0002437 30 0.141
stem cell development GO:0048864 219 0.140
antigen processing and presentation of exogenous antigen GO:0019884 26 0.138
positive regulation of interleukin 6 production GO:0032755 37 0.137
regulation of t cell mediated immunity GO:0002709 34 0.136
negative regulation of t cell mediated immunity GO:0002710 9 0.135
regulation of phospholipase c activity GO:1900274 3 0.134
Mouse
dna metabolic process GO:0006259 303 0.133
immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 43 0.133
regulation of neuron differentiation GO:0045664 281 0.132
Mouse
ras protein signal transduction GO:0007265 77 0.130
regulation of mast cell degranulation GO:0043304 16 0.130
Mouse
positive regulation of b cell receptor signaling pathway GO:0050861 4 0.129
Mouse
regulation of production of molecular mediator of immune response GO:0002700 65 0.128
b cell receptor signaling pathway GO:0050853 20 0.127
cation transport GO:0006812 399 0.126
regulation of myeloid cell differentiation GO:0045637 96 0.125
Mouse
mast cell activation involved in immune response GO:0002279 20 0.123
Mouse
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 45 0.120
striated muscle cell development GO:0055002 125 0.120
regulation of inflammatory response GO:0050727 147 0.119
Mouse
regulation of coagulation GO:0050818 31 0.119
Mouse
lymphocyte activation involved in immune response GO:0002285 93 0.118
positive regulation of leukocyte proliferation GO:0070665 73 0.116
regulation of type ii hypersensitivity GO:0002892 4 0.115
endocytosis GO:0006897 168 0.113
Mouse
positive regulation of hydrolase activity GO:0051345 148 0.113
Human Mouse
production of molecular mediator of immune response GO:0002440 103 0.112
positive regulation of cytokine production GO:0001819 174 0.112
Mouse
positive regulation of tyrosine phosphorylation of stat5 protein GO:0042523 6 0.111
positive regulation of t cell mediated immunity GO:0002711 24 0.110
positive regulation of alpha beta t cell differentiation GO:0046638 28 0.110
b cell activation involved in immune response GO:0002312 50 0.108
positive regulation of lymphocyte anergy GO:0002913 4 0.107
regulation of hemostasis GO:1900046 28 0.107
Mouse
regulation of lymphocyte proliferation GO:0050670 117 0.106
Mouse
positive regulation of apoptotic signaling pathway GO:2001235 95 0.105
Human
cation homeostasis GO:0055080 212 0.104
negative regulation of transferase activity GO:0051348 85 0.101
Mouse
neuron migration GO:0001764 122 0.100
Mouse
positive regulation of adaptive immune response GO:0002821 61 0.100
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.100
toll like receptor 4 signaling pathway GO:0034142 9 0.099
Mouse
positive regulation of immunoglobulin mediated immune response GO:0002891 26 0.097
t cell mediated immunity GO:0002456 50 0.096
regulation of type iii hypersensitivity GO:0001803 3 0.096
jak stat cascade GO:0007259 42 0.095
positive regulation of programmed cell death GO:0043068 218 0.095
Human Mouse
regulation of stress activated mapk cascade GO:0032872 69 0.095
olfactory learning GO:0008355 2 0.095
Fly
myeloid leukocyte activation GO:0002274 83 0.095
Mouse
erythrocyte differentiation GO:0030218 88 0.095
Mouse
positive regulation of innate immune response GO:0045089 80 0.093
Mouse
wnt signaling pathway GO:0016055 188 0.092
Mouse
dendritic spine maintenance GO:0097062 4 0.092
stress activated protein kinase signaling cascade GO:0031098 81 0.092
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.091
Fly
positive regulation of alpha beta t cell activation GO:0046635 39 0.090
positive regulation of dendritic cell apoptotic process GO:2000670 3 0.090
Mouse
homotypic cell cell adhesion GO:0034109 28 0.090
Mouse
mammary gland epithelium development GO:0061180 65 0.089
Mouse
regulation of jnk cascade GO:0046328 62 0.088
activation of janus kinase activity GO:0042976 2 0.088
positive regulation of leukocyte degranulation GO:0043302 10 0.088
Mouse
regulation of cytokine production involved in immune response GO:0002718 26 0.087
regulation of actin filament based process GO:0032970 99 0.087
Fly
jnk cascade GO:0007254 72 0.086
dendritic spine organization GO:0097061 26 0.086
response to molecule of fungal origin GO:0002238 4 0.086
positive regulation of intracellular transport GO:0032388 70 0.085
Mouse
regulation of stem cell proliferation GO:0072091 78 0.085
alpha beta t cell differentiation GO:0046632 69 0.085
Mouse
regulation of lymphocyte mediated immunity GO:0002706 84 0.084
cellular response to cytokine stimulus GO:0071345 189 0.083
negative regulation of mast cell proliferation GO:0070667 1 0.082
Mouse
positive regulation of growth hormone receptor signaling pathway GO:0060399 3 0.081
regulation of tyrosine phosphorylation of stat protein GO:0042509 20 0.081
negative regulation of t cell apoptotic process GO:0070233 18 0.081
negative regulation of leukocyte apoptotic process GO:2000107 31 0.081
protein processing GO:0016485 163 0.080
Human
positive regulation of t cell anergy GO:0002669 4 0.080
regulation of phosphatidylinositol 3 kinase signaling GO:0014066 30 0.080
striated muscle tissue development GO:0014706 293 0.080
actin polymerization or depolymerization GO:0008154 54 0.079
Fly
cellular protein complex assembly GO:0043623 116 0.079
protein lipidation GO:0006497 28 0.079
myeloid leukocyte migration GO:0097529 57 0.079
b cell activation GO:0042113 161 0.079
Mouse
membrane invagination GO:0010324 17 0.078
negative regulation of synapse assembly GO:0051964 3 0.077
Fly
regulation of anatomical structure size GO:0090066 178 0.076
Fly
skeletal system development GO:0001501 356 0.076
sequestering of calcium ion GO:0051208 18 0.076
antigen processing and presentation of peptide antigen GO:0048002 29 0.075
response to molecule of bacterial origin GO:0002237 143 0.074
Mouse
interferon gamma production GO:0032609 67 0.073
Mouse
phagocytosis GO:0006909 66 0.073
Mouse
negative regulation of erk1 and erk2 cascade GO:0070373 21 0.073
Mouse
regulation of exocytosis GO:0017157 61 0.072
Mouse
i kappab kinase nf kappab signaling GO:0007249 85 0.072
Mouse
calcium ion homeostasis GO:0055074 127 0.072
regulation of wound healing GO:0061041 40 0.072
Mouse
regulation of wnt signaling pathway GO:0030111 123 0.072
Mouse
positive regulation of cytosolic calcium ion concentration GO:0007204 65 0.072
fc receptor signaling pathway GO:0038093 6 0.071
gonad development GO:0008406 141 0.071
Worm
regionalization GO:0003002 337 0.071
negative regulation of adaptive immune response GO:0002820 25 0.071
somatic recombination of immunoglobulin genes involved in immune response GO:0002204 36 0.071
modulation by virus of host morphology or physiology GO:0019048 3 0.070
immune response regulating cell surface receptor signaling pathway GO:0002768 80 0.070
transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 1 0.070
regulation of protein import into nucleus GO:0042306 52 0.070
wound healing GO:0042060 157 0.070
Mouse
protein maturation GO:0051604 176 0.069
Human
regulation of proteolysis GO:0030162 164 0.069
Human
b cell apoptotic process GO:0001783 19 0.068
Mouse
positive regulation of leukocyte apoptotic process GO:2000108 21 0.067
Mouse
neutrophil degranulation GO:0043312 6 0.067
nucleocytoplasmic transport GO:0006913 139 0.067
isotype switching GO:0045190 36 0.067
regulation of podosome assembly GO:0071801 3 0.066
Mouse
negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 23 0.066
cell killing GO:0001906 67 0.066
negative regulation of response to cytokine stimulus GO:0060761 9 0.065
compound eye development GO:0048749 1 0.065
bone remodeling GO:0046849 53 0.065
Mouse
regulation of membrane potential GO:0042391 192 0.064
regulation of myeloid leukocyte differentiation GO:0002761 58 0.064
Mouse
regulation of b cell mediated immunity GO:0002712 37 0.064
regulation of cellular component size GO:0032535 121 0.063
Fly
regulation of actin filament polymerization GO:0030833 38 0.063
dna recombination GO:0006310 92 0.063
negative regulation of b cell proliferation GO:0030889 13 0.063
Mouse
actin cytoskeleton organization GO:0030036 220 0.063
Fly
protein import into nucleus GO:0006606 95 0.063
regulation of mast cell proliferation GO:0070666 4 0.062
Mouse
positive regulation of alpha beta t cell proliferation GO:0046641 12 0.062
actin filament based movement GO:0030048 23 0.062
regulation of acute inflammatory response GO:0002673 27 0.062
cellular response to acid chemical GO:0071229 68 0.061
Mouse
regulation of myeloid leukocyte mediated immunity GO:0002886 25 0.061
Mouse
intracellular protein transport GO:0006886 204 0.061
lymphocyte proliferation GO:0046651 164 0.060
Mouse
cd4 positive alpha beta t cell activation GO:0035710 45 0.060
activation of mapk activity GO:0000187 59 0.060
regulation of t cell receptor signaling pathway GO:0050856 21 0.060
regulation of actin filament length GO:0030832 45 0.060
Fly
regulation of leukocyte degranulation GO:0043300 20 0.059
Mouse
organelle assembly GO:0070925 177 0.059
Mouse
regulation of protein transport GO:0051223 163 0.059
Mouse
podosome assembly GO:0071800 6 0.059
Mouse
sequestering of metal ion GO:0051238 19 0.058
positive regulation of b cell differentiation GO:0045579 13 0.058
regulation of protein autophosphorylation GO:0031952 8 0.058
regulation of interleukin 6 production GO:0032675 55 0.057
response to acid chemical GO:0001101 111 0.057
Mouse
cellular response to hormone stimulus GO:0032870 150 0.057
regulation of canonical wnt signaling pathway GO:0060828 82 0.057
Mouse
regulation of cell adhesion GO:0030155 154 0.057
Mouse
somatic diversification of immunoglobulins involved in immune response GO:0002208 36 0.057
regulation of cell cycle GO:0051726 281 0.056
regulation of ion homeostasis GO:2000021 64 0.056
establishment or maintenance of cell polarity GO:0007163 86 0.056
Worm
antigen processing and presentation of exogenous peptide antigen via mhc class ii GO:0019886 14 0.056
positive regulation of acute inflammatory response GO:0002675 16 0.056
mast cell activation GO:0045576 27 0.056
Mouse
regulation of hydrolase activity GO:0051336 246 0.056
Human Mouse
positive regulation of granulocyte macrophage colony stimulating factor biosynthetic process GO:0045425 2 0.055
zymogen activation GO:0031638 41 0.055
Human
memory GO:0007613 58 0.054
Fly
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.054
cell type specific apoptotic process GO:0097285 268 0.054
Mouse
maintenance of location GO:0051235 89 0.054
erk1 and erk2 cascade GO:0070371 77 0.053
Mouse
positive regulation of response to wounding GO:1903036 66 0.053
regulation of type i hypersensitivity GO:0001810 4 0.053
single organism nuclear import GO:1902593 95 0.052
positive regulation of cytoskeleton organization GO:0051495 49 0.052
interleukin 6 production GO:0032635 58 0.052
dephosphorylation GO:0016311 129 0.052
Human
positive regulation of map kinase activity GO:0043406 84 0.052
positive regulation of mast cell activation GO:0033005 12 0.052
Mouse
sensory perception GO:0007600 245 0.051
Mouse
positive regulation of intracellular protein transport GO:0090316 42 0.051
positive regulation of type i hypersensitivity GO:0001812 3 0.051
protein targeting GO:0006605 143 0.051
positive regulation of translational initiation GO:0045948 4 0.050
salivary gland development GO:0007431 37 0.050
Fly
establishment of protein localization to organelle GO:0072594 118 0.049
positive regulation of lymphocyte mediated immunity GO:0002708 62 0.049
somatic diversification of immunoglobulins GO:0016445 43 0.049
regulation of b cell activation GO:0050864 81 0.049
Mouse
mast cell homeostasis GO:0033023 5 0.048
positive regulation of myeloid leukocyte cytokine production involved in immune response GO:0061081 9 0.048
actin mediated cell contraction GO:0070252 15 0.048
epithelial cell migration GO:0010631 63 0.048
cellularization GO:0007349 1 0.047
Fly
neuron projection extension GO:1990138 64 0.047
regulation of cytoskeleton organization GO:0051493 122 0.047
Fly
detection of mechanical stimulus involved in sensory perception of pain GO:0050966 4 0.047
Mouse
stem cell differentiation GO:0048863 268 0.047
smoothened signaling pathway GO:0007224 105 0.046
positive regulation of exocytosis GO:0045921 20 0.046
Mouse
phosphatidylinositol 3 kinase signaling GO:0014065 36 0.046
negative regulation of lymphocyte apoptotic process GO:0070229 24 0.046
positive regulation of canonical wnt signaling pathway GO:0090263 29 0.046
Mouse
actin filament polymerization GO:0030041 44 0.046
regulation of immunoglobulin mediated immune response GO:0002889 37 0.046
t cell homeostatic proliferation GO:0001777 4 0.045
motor neuron axon guidance GO:0008045 26 0.045
lysosome localization GO:0032418 20 0.045
Mouse
neuron projection guidance GO:0097485 141 0.045
Fly
regulation of hematopoietic stem cell migration GO:2000471 1 0.045
heterotypic cell cell adhesion GO:0034113 7 0.045
negative regulation of t cell activation GO:0050868 65 0.044
axon guidance GO:0007411 141 0.044
Fly
positive regulation of type iia hypersensitivity GO:0001798 4 0.044
negative regulation of toll like receptor signaling pathway GO:0034122 14 0.044
Mouse
protein catabolic process GO:0030163 221 0.044
Mouse
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.044
positive regulation of cell adhesion GO:0045785 80 0.044
response to stem cell factor GO:0036215 3 0.044
regulation of tumor necrosis factor production GO:0032680 49 0.043
cd4 positive alpha beta t cell differentiation GO:0043367 41 0.043
response to ionizing radiation GO:0010212 42 0.043
cellular response to peptide hormone stimulus GO:0071375 92 0.043
positive regulation of interleukin 8 secretion GO:2000484 1 0.042
regulation of tissue remodeling GO:0034103 38 0.042
t cell receptor v d j recombination GO:0033153 5 0.042
substrate dependent cell migration cell extension GO:0006930 4 0.041
regulation of dendritic cell cytokine production GO:0002730 2 0.041
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 34 0.041
synapse assembly GO:0007416 56 0.041
Fly
cellular ion homeostasis GO:0006873 165 0.041
natural killer cell proliferation GO:0001787 3 0.041
positive regulation of interferon gamma production GO:0032729 39 0.041
negative regulation of protein phosphorylation GO:0001933 126 0.040
Mouse
stem cell maintenance GO:0019827 130 0.040
antigen processing and presentation of peptide or polysaccharide antigen via mhc class ii GO:0002504 17 0.040
maintenance of location in cell GO:0051651 24 0.040
interleukin 8 secretion GO:0072606 3 0.039
positive regulation of t cell costimulation GO:2000525 2 0.039
regulation of cell cycle process GO:0010564 160 0.039
cellular response to molecule of fungal origin GO:0071226 2 0.039
negative regulation of protein autophosphorylation GO:0031953 2 0.039
regulation of interferon gamma secretion GO:1902713 3 0.038
positive regulation of b cell proliferation GO:0030890 24 0.038
positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 6 0.038
cellular response to organonitrogen compound GO:0071417 145 0.038
response to radiation GO:0009314 165 0.038
regulation of mapk cascade GO:0043408 248 0.038
Mouse
male gamete generation GO:0048232 285 0.038
regulation of cd4 positive alpha beta t cell differentiation GO:0043370 21 0.038
myeloid leukocyte cytokine production GO:0061082 12 0.038
protein polymerization GO:0051258 57 0.037
regulation of action potential GO:0098900 4 0.037
peptidyl serine phosphorylation GO:0018105 74 0.037
positive regulation of cell development GO:0010720 237 0.037
Mouse
mast cell mediated immunity GO:0002448 20 0.037
Mouse
positive regulation of nucleocytoplasmic transport GO:0046824 30 0.036
rac protein signal transduction GO:0016601 13 0.036
mapk cascade GO:0000165 281 0.036
Mouse
regulation of insulin receptor signaling pathway GO:0046626 21 0.036
coagulation GO:0050817 78 0.036
Mouse
negative regulation of nervous system development GO:0051961 156 0.036
Fly
forebrain development GO:0030900 302 0.035
Mouse
positive regulation of jnk cascade GO:0046330 46 0.035
regulation of cysteine type endopeptidase activity GO:2000116 65 0.035
Human
t cell differentiation involved in immune response GO:0002292 30 0.035
positive regulation of cytokine secretion GO:0050715 41 0.035
Mouse
axonogenesis GO:0007409 274 0.035
Fly
asymmetric neuroblast division GO:0055059 1 0.035
positive regulation of phospholipase c activity GO:0010863 2 0.035
Mouse
positive regulation of phosphatidylinositol 3 kinase signaling GO:0014068 20 0.035
positive regulation of tyrosine phosphorylation of stat protein GO:0042531 15 0.035
positive regulation of stem cell proliferation GO:2000648 59 0.034
cellular response to peptide GO:1901653 92 0.034
interspecies interaction between organisms GO:0044419 83 0.034
t cell apoptotic process GO:0070231 39 0.034
single organism cell adhesion GO:0098602 156 0.034
Mouse Fly
negative regulation of apoptotic signaling pathway GO:2001234 104 0.034
maintenance of protein location in cell GO:0032507 20 0.034
engulfment of apoptotic cell GO:0043652 3 0.034
leukocyte mediated cytotoxicity GO:0001909 62 0.033
regulation of mitotic cell cycle GO:0007346 126 0.033
cellular divalent inorganic cation homeostasis GO:0072503 127 0.033
positive regulation of jun kinase activity GO:0043507 30 0.033
intracellular steroid hormone receptor signaling pathway GO:0030518 29 0.033
Mouse
skeletal muscle organ development GO:0060538 163 0.033
stem cell proliferation GO:0072089 117 0.033

Lck disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
primary immunodeficiency disease DOID:612 0 0.135
severe combined immunodeficiency DOID:627 0 0.135
combined t cell and b cell immunodeficiency DOID:628 0 0.135
immune system disease DOID:2914 0 0.135
disease of anatomical entity DOID:7 0 0.135