Mus musculus

133 known processes

Ldlr

low density lipoprotein receptor

(Aliases: Hlb301)

Ldlr biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
sterol metabolic process GO:0016125 58 1.000
steroid metabolic process GO:0008202 119 1.000
cholesterol metabolic process GO:0008203 56 1.000
alcohol metabolic process GO:0006066 116 0.991
regulation of plasma lipoprotein particle levels GO:0097006 23 0.988
cholesterol esterification GO:0034435 3 0.981
cholesterol biosynthetic process GO:0006695 15 0.980
cellular alcohol biosynthetic process GO:0044108 3 0.980
sterol transport GO:0015918 38 0.971
sterol biosynthetic process GO:0016126 17 0.968
lipid biosynthetic process GO:0008610 179 0.964
regulation of removal of superoxide radicals GO:2000121 4 0.959
sterol esterification GO:0034434 3 0.957
regulation of cholesterol metabolic process GO:0090181 14 0.935
organic hydroxy compound metabolic process GO:1901615 203 0.924
cellular lipid metabolic process GO:0044255 323 0.922
cholesterol storage GO:0010878 4 0.916
alcohol biosynthetic process GO:0046165 43 0.911
regulation of cellular ketone metabolic process GO:0010565 66 0.904
lipid homeostasis GO:0055088 63 0.877
steroid esterification GO:0034433 3 0.875
reverse cholesterol transport GO:0043691 6 0.872
organic hydroxy compound biosynthetic process GO:1901617 77 0.848
regulation of cellular amino acid metabolic process GO:0006521 5 0.838
cellular alcohol metabolic process GO:0044107 3 0.837
triglyceride metabolic process GO:0006641 51 0.825
cholesterol transport GO:0030301 38 0.817
sterol homeostasis GO:0055092 45 0.813
cellular response to peptide GO:1901653 92 0.786
phospholipid metabolic process GO:0006644 87 0.773
cellular amino acid metabolic process GO:0006520 103 0.733
regulation of sterol transport GO:0032371 17 0.727
regulation of reactive oxygen species metabolic process GO:2000377 40 0.726
glycerolipid metabolic process GO:0046486 122 0.723
plasma lipoprotein particle organization GO:0071827 11 0.691
plasma lipoprotein particle clearance GO:0034381 13 0.683
regulation of intrinsic apoptotic signaling pathway in response to osmotic stress GO:1902218 1 0.657
high density lipoprotein particle assembly GO:0034380 3 0.655
glycerophospholipid metabolic process GO:0006650 71 0.650
regulation of cholesterol biosynthetic process GO:0045540 8 0.644
response to radiation GO:0009314 165 0.638
lipid localization GO:0010876 126 0.625
response to oxygen radical GO:0000305 16 0.624
lung development GO:0030324 164 0.624
response to low density lipoprotein particle GO:0055098 2 0.613
protein lipid complex subunit organization GO:0071825 12 0.611
positive regulation of hydrolase activity GO:0051345 148 0.609
positive regulation of sterol transport GO:0032373 9 0.594
regulation of lipase activity GO:0060191 15 0.574
response to amino acid GO:0043200 37 0.574
amide transport GO:0042886 138 0.573
cellular response to cytokine stimulus GO:0071345 189 0.566
cellular response to oxygen radical GO:0071450 14 0.550
negative regulation of sterol transport GO:0032372 4 0.546
protein lipid complex remodeling GO:0034368 6 0.537
drug catabolic process GO:0042737 2 0.534
positive regulation of reactive oxygen species metabolic process GO:2000379 11 0.526
cellular response to organonitrogen compound GO:0071417 145 0.521
positive regulation of triglyceride lipase activity GO:0061365 3 0.518
cellular amine metabolic process GO:0044106 44 0.514
lipid transport GO:0006869 98 0.510
cellular response to amino acid stimulus GO:0071230 29 0.506
epithelial cell proliferation GO:0050673 174 0.502
respiratory tube development GO:0030323 167 0.501
amine metabolic process GO:0009308 45 0.498
blood circulation GO:0008015 195 0.497
very low density lipoprotein particle remodeling GO:0034372 1 0.491
small molecule biosynthetic process GO:0044283 132 0.491
response to organonitrogen compound GO:0010243 246 0.489
Rat
extracellular matrix organization GO:0030198 147 0.489
innate immune response GO:0045087 157 0.483
reactive oxygen species metabolic process GO:0072593 84 0.483
mating behavior sex discrimination GO:0048047 1 0.479
negative regulation of growth of symbiont involved in interaction with host GO:0044146 19 0.474
cytokine mediated signaling pathway GO:0019221 115 0.471
metanephric glomerular mesangium development GO:0072223 3 0.470
regulation of hydrolase activity GO:0051336 246 0.469
neutral lipid metabolic process GO:0006638 57 0.466
regulation of cell migration GO:0030334 219 0.461
regulation of growth of symbiont in host GO:0044126 19 0.457
cellular response to lipid GO:0071396 145 0.455
ovarian follicle development GO:0001541 40 0.449
luteinization GO:0001553 8 0.448
negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis GO:2000162 1 0.445
positive regulation of lipase activity GO:0060193 6 0.445
glycerolipid biosynthetic process GO:0045017 50 0.441
organic hydroxy compound transport GO:0015850 93 0.437
positive regulation of cholesterol transport GO:0032376 9 0.436
removal of superoxide radicals GO:0019430 12 0.434
positive regulation of presynaptic membrane organization GO:1901631 1 0.432
phospholipid transport GO:0015914 21 0.426
regulation of hormone levels GO:0010817 211 0.425
jak stat cascade GO:0007259 42 0.424
sphingolipid metabolic process GO:0006665 45 0.421
positive regulation of lipoprotein lipase activity GO:0051006 3 0.414
respiratory system development GO:0060541 190 0.414
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.413
activation of mapkk activity GO:0000186 15 0.402
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 45 0.402
digestive tract development GO:0048565 190 0.392
acylglycerol metabolic process GO:0006639 55 0.389
plasma lipoprotein particle remodeling GO:0034369 6 0.389
regulation of cellular catabolic process GO:0031329 242 0.379
response to peptide hormone GO:0043434 127 0.378
Rat
regulation of lipid metabolic process GO:0019216 118 0.376
cellular response to acid chemical GO:0071229 68 0.374
membrane lipid metabolic process GO:0006643 53 0.374
positive regulation of nitric oxide synthase activity GO:0051000 2 0.374
regulation of blood circulation GO:1903522 93 0.364
skeletal system morphogenesis GO:0048705 203 0.361
cytokine production involved in immune response GO:0002367 34 0.355
steroid biosynthetic process GO:0006694 47 0.354
response to steroid hormone GO:0048545 56 0.353
Rat
cation homeostasis GO:0055080 212 0.351
cellular response to superoxide GO:0071451 14 0.350
peptidyl amino acid modification GO:0018193 336 0.344
Mouse
divalent inorganic cation homeostasis GO:0072507 138 0.337
tyrosine phosphorylation of stat protein GO:0007260 23 0.335
regulation of adrenergic receptor signaling pathway GO:0071877 4 0.332
extracellular structure organization GO:0043062 148 0.331
negative regulation of cellular amide metabolic process GO:0034249 4 0.322
negative regulation of cholesterol transport GO:0032375 4 0.319
calcium ion homeostasis GO:0055074 127 0.316
elastic fiber assembly GO:0048251 4 0.315
cholesterol efflux GO:0033344 24 0.313
maintenance of location GO:0051235 89 0.310
regulation of cholesterol transport GO:0032374 17 0.309
lipoprotein metabolic process GO:0042157 43 0.304
homeostasis of number of cells GO:0048872 210 0.302
response to hyperoxia GO:0055093 2 0.298
cellular response to interleukin 18 GO:0071351 3 0.295
cellular chemical homeostasis GO:0055082 215 0.291
response to superoxide GO:0000303 16 0.286
organonitrogen compound biosynthetic process GO:1901566 192 0.284
response to increased oxygen levels GO:0036296 2 0.282
positive regulation of protein modification process GO:0031401 299 0.280
Mouse
negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator GO:1902239 1 0.273
negative regulation of cellular amine metabolic process GO:0033239 1 0.272
oxidation reduction process GO:0055114 342 0.271
circulatory system process GO:0003013 197 0.270
cell chemotaxis GO:0060326 81 0.265
metal ion homeostasis GO:0055065 189 0.261
regulation of mapk cascade GO:0043408 248 0.261
cdc42 protein signal transduction GO:0032488 0 0.261
interleukin 18 mediated signaling pathway GO:0035655 2 0.257
development of primary female sexual characteristics GO:0046545 73 0.253
regulation of neurotrophin trk receptor signaling pathway GO:0051386 4 0.251
acylglycerol biosynthetic process GO:0046463 18 0.250
vascular process in circulatory system GO:0003018 62 0.250
regulation of blood vessel size GO:0050880 56 0.249
positive regulation of triglyceride metabolic process GO:0090208 9 0.246
cellular response to insulin stimulus GO:0032869 78 0.245
regulation of response to oxidative stress GO:1902882 19 0.245
positive regulation of kinase activity GO:0033674 155 0.244
Mouse
regulation of secretion GO:0051046 274 0.242
cell substrate adhesion GO:0031589 130 0.241
defense response to other organism GO:0098542 197 0.241
response to oxidative stress GO:0006979 123 0.241
heart contraction GO:0060047 93 0.241
regulation of beta amyloid clearance GO:1900221 1 0.240
regulation of tissue remodeling GO:0034103 38 0.239
skin development GO:0043588 220 0.238
macromolecule glycosylation GO:0043413 55 0.237
regulation of heart contraction GO:0008016 77 0.236
organophosphate ester transport GO:0015748 28 0.235
cellular ketone metabolic process GO:0042180 84 0.233
positive regulation of mapk cascade GO:0043410 170 0.233
embryonic skeletal system development GO:0048706 120 0.232
cellular calcium ion homeostasis GO:0006874 119 0.231
response to acid chemical GO:0001101 111 0.231
response to lipopolysaccharide GO:0032496 128 0.230
cellular response to hormone stimulus GO:0032870 150 0.226
regulation of system process GO:0044057 200 0.225
face morphogenesis GO:0060325 29 0.225
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.222
regulation of innate immune response GO:0045088 91 0.220
response to organic cyclic compound GO:0014070 198 0.220
Rat
positive regulation of peptidase activity GO:0010952 49 0.219
regulation of organelle organization GO:0033043 289 0.218
response to insulin GO:0032868 100 0.217
forebrain development GO:0030900 302 0.215
Mouse
acylglycerol homeostasis GO:0055090 16 0.213
platelet derived growth factor receptor alpha signaling pathway GO:0035790 3 0.213
regulation of angiogenesis GO:0045765 81 0.212
cellular response to biotic stimulus GO:0071216 92 0.209
production of molecular mediator of immune response GO:0002440 103 0.207
drug metabolic process GO:0017144 4 0.207
angiogenesis GO:0001525 201 0.200
cartilage development GO:0051216 140 0.199
detection of molecule of bacterial origin GO:0032490 2 0.198
divalent metal ion transport GO:0070838 172 0.198
g protein coupled receptor signaling pathway GO:0007186 243 0.198
regulation of apoptotic signaling pathway GO:2001233 197 0.195
odontogenesis of dentin containing tooth GO:0042475 66 0.195
peptidyl tyrosine phosphorylation GO:0018108 143 0.194
Mouse
limb morphogenesis GO:0035108 149 0.194
regulation of cellular amine metabolic process GO:0033238 20 0.194
smooth muscle cell chemotaxis GO:0071670 2 0.193
lung alveolus development GO:0048286 45 0.192
small molecule catabolic process GO:0044282 71 0.192
cellular amide metabolic process GO:0043603 58 0.191
regulation of phospholipase c activity GO:1900274 3 0.191
negative regulation of apoptotic signaling pathway GO:2001234 104 0.190
negative regulation of intracellular signal transduction GO:1902532 167 0.188
tissue homeostasis GO:0001894 115 0.186
intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator GO:1990127 1 0.185
glycoprotein metabolic process GO:0009100 116 0.185
hormone secretion GO:0046879 128 0.185
regulation of fatty acid metabolic process GO:0019217 28 0.184
bone mineralization GO:0030282 54 0.183
regulation of phosphatidylcholine catabolic process GO:0010899 2 0.181
response to growth factor GO:0070848 198 0.181
regulation of phospholipid efflux GO:1902994 2 0.179
covalent chromatin modification GO:0016569 163 0.177
epidermis development GO:0008544 187 0.176
protein catabolic process GO:0030163 221 0.173
negative regulation of peptide hormone secretion GO:0090278 16 0.173
negative regulation of systemic arterial blood pressure GO:0003085 15 0.173
cytokine production GO:0001816 319 0.172
regulation of cholesterol esterification GO:0010872 2 0.172
exogenous drug catabolic process GO:0042738 1 0.171
regulation of jak stat cascade GO:0046425 34 0.170
cellular response to peptide hormone stimulus GO:0071375 92 0.170
response to molecule of bacterial origin GO:0002237 143 0.169
negative regulation of blood vessel endothelial cell migration GO:0043537 3 0.168
positive regulation of apoptotic cell clearance GO:2000427 3 0.167
multicellular organismal homeostasis GO:0048871 164 0.166
superoxide metabolic process GO:0006801 27 0.166
small gtpase mediated signal transduction GO:0007264 97 0.165
response to extracellular stimulus GO:0009991 127 0.164
bone morphogenesis GO:0060349 78 0.163
head morphogenesis GO:0060323 34 0.163
cytoplasmic transport GO:0016482 234 0.162
regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator GO:1902238 1 0.162
positive regulation of metanephros development GO:0072216 9 0.162
response to inorganic substance GO:0010035 96 0.161
regulation of lymphocyte activation GO:0051249 240 0.161
positive regulation of lipid storage GO:0010884 10 0.161
regulation of proteolysis GO:0030162 164 0.160
regulation of peptide transport GO:0090087 91 0.160
positive regulation of cholesterol esterification GO:0010873 1 0.159
blood vessel morphogenesis GO:0048514 285 0.159
modulation of growth of symbiont involved in interaction with host GO:0044144 19 0.158
skeletal system development GO:0001501 356 0.158
phospholipase c activating angiotensin activated signaling pathway GO:0086097 1 0.158
regulation of lipoprotein lipase activity GO:0051004 4 0.157
response to sterol GO:0036314 4 0.157
regulation of response to reactive oxygen species GO:1901031 9 0.155
regulation of blood pressure GO:0008217 93 0.155
muscle contraction GO:0006936 101 0.154
positive regulation of proteolysis GO:0045862 85 0.153
heart process GO:0003015 94 0.153
interspecies interaction between organisms GO:0044419 83 0.151
vasodilation by angiotensin involved in regulation of systemic arterial blood pressure GO:0002033 2 0.150
g protein coupled receptor signaling pathway coupled to cgmp nucleotide second messenger GO:0007199 1 0.148
negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis GO:2000149 1 0.147
platelet derived growth factor receptor signaling pathway GO:0048008 32 0.146
intracellular cholesterol transport GO:0032367 3 0.145
myeloid cell differentiation GO:0030099 233 0.145
erk1 and erk2 cascade GO:0070371 77 0.145
glycoprotein biosynthetic process GO:0009101 89 0.144
regulation of map kinase activity GO:0043405 120 0.143
positive regulation of phospholipase activity GO:0010518 3 0.143
lipid modification GO:0030258 65 0.141
alpha amino acid metabolic process GO:1901605 59 0.140
hormone metabolic process GO:0042445 86 0.139
regulation of peptidase activity GO:0052547 96 0.137
morphogenesis of a branching structure GO:0001763 203 0.137
regulation of b cell differentiation GO:0045577 23 0.137
intrinsic apoptotic signaling pathway in response to osmotic stress GO:0008627 2 0.136
response to monosaccharide GO:0034284 67 0.136
modulation by symbiont of defense related host nitric oxide production GO:0052163 1 0.136
cellular response to oxidative stress GO:0034599 76 0.135
regulation of actin filament based process GO:0032970 99 0.135
glucose homeostasis GO:0042593 128 0.134
positive regulation of cellular amine metabolic process GO:0033240 5 0.133
defense response to bacterium GO:0042742 119 0.133
regulation of renal output by angiotensin GO:0002019 2 0.133
positive regulation of dendrite development GO:1900006 21 0.133
Mouse
fatty acid metabolic process GO:0006631 121 0.132
regulation of immune complex clearance by monocytes and macrophages GO:0090264 2 0.131
interleukin 33 mediated signaling pathway GO:0038172 1 0.131
lipoprotein biosynthetic process GO:0042158 33 0.131
positive regulation of map kinase activity GO:0043406 84 0.129
positive regulation of triglyceride biosynthetic process GO:0010867 6 0.128
vasodilation GO:0042311 28 0.128
intestinal absorption GO:0050892 13 0.128
Human
anatomical structure homeostasis GO:0060249 145 0.128
regulation of vasculature development GO:1901342 88 0.127
regulation of cell projection organization GO:0031344 206 0.126
Mouse
regulation of intestinal cholesterol absorption GO:0030300 4 0.126
calcium ion transport GO:0006816 159 0.125
muscle tissue development GO:0060537 308 0.124
defense response to gram positive bacterium GO:0050830 50 0.124
sterol transmembrane transport GO:0035382 2 0.123
growth of symbiont involved in interaction with host GO:0044116 23 0.121
negative regulation of nervous system development GO:0051961 156 0.120
organic acid transport GO:0015849 101 0.120
myeloid leukocyte differentiation GO:0002573 119 0.120
positive regulation of erk1 and erk2 cascade GO:0070374 47 0.120
negative regulation of cellular component organization GO:0051129 194 0.119
growth of symbiont in host GO:0044117 23 0.119
high density lipoprotein particle remodeling GO:0034375 4 0.119
positive regulation of cholesterol storage GO:0010886 3 0.117
cellular response to lipopolysaccharide GO:0071222 77 0.117
glycosylation GO:0070085 62 0.117
positive regulation of cholesterol efflux GO:0010875 9 0.117
regulation of cellular response to oxidative stress GO:1900407 19 0.117
regulation of multi organism process GO:0043900 111 0.116
negative regulation of cell migration GO:0030336 59 0.116
apoptotic process involved in mammary gland involution GO:0060057 4 0.116
plasma lipoprotein particle assembly GO:0034377 6 0.116
triglyceride rich lipoprotein particle remodeling GO:0034370 2 0.116
protein glycosylation GO:0006486 55 0.115
carboxylic acid catabolic process GO:0046395 51 0.115
bone resorption GO:0045453 38 0.114
response to nutrient levels GO:0031667 109 0.114
monocarboxylic acid metabolic process GO:0032787 191 0.113
muscle cell proliferation GO:0033002 52 0.113
peptide hormone secretion GO:0030072 109 0.111
leukocyte homeostasis GO:0001776 79 0.110
regulation of blood vessel remodeling GO:0060312 3 0.109
response to macrophage colony stimulating factor GO:0036005 3 0.109
ras protein signal transduction GO:0007265 77 0.108
leukocyte migration GO:0050900 124 0.108
development of primary sexual characteristics GO:0045137 143 0.108
regulation of steroid metabolic process GO:0019218 39 0.108
leukocyte differentiation GO:0002521 342 0.107
negative regulation of molecular function GO:0044092 258 0.106
divalent inorganic cation transport GO:0072511 178 0.104
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.104
growth involved in symbiotic interaction GO:0044110 23 0.104
response to estrogen GO:0043627 24 0.104
Rat
cardiocyte differentiation GO:0035051 87 0.103
positive regulation of monooxygenase activity GO:0032770 2 0.102
response to vitamin a GO:0033189 1 0.102
protein maturation GO:0051604 176 0.101
regulation of transferase activity GO:0051338 263 0.101
Mouse
regulation of planar cell polarity pathway involved in ventricular septum morphogenesis GO:2000148 1 0.101
insulin receptor signaling pathway GO:0008286 49 0.101
negative regulation of planar cell polarity pathway involved in pericardium morphogenesis GO:2000166 1 0.100
erythrocyte differentiation GO:0030218 88 0.100
t cell activation GO:0042110 289 0.100
negative regulation of response to cytokine stimulus GO:0060761 9 0.100
regulation of establishment of protein localization GO:0070201 181 0.100
liver development GO:0001889 66 0.100
antibacterial peptide secretion GO:0002779 1 0.100
regulation of cell activation GO:0050865 289 0.099
negative regulation of insulin secretion GO:0046676 14 0.099
myeloid leukocyte activation GO:0002274 83 0.099
regulation of cellular response to stress GO:0080135 159 0.098
protein processing GO:0016485 163 0.098
positive regulation of lipid metabolic process GO:0045834 40 0.098
hematopoietic progenitor cell differentiation GO:0002244 143 0.098
regulation of monooxygenase activity GO:0032768 7 0.097
apoptotic signaling pathway GO:0097190 306 0.096
organ regeneration GO:0031100 2 0.096
appendage morphogenesis GO:0035107 149 0.096
serotonin uptake GO:0051610 3 0.095
macrophage colony stimulating factor signaling pathway GO:0038145 2 0.095
appendage development GO:0048736 166 0.094
odontogenesis GO:0042476 78 0.094
palate development GO:0060021 76 0.092
regulation of intrinsic apoptotic signaling pathway GO:2001242 61 0.092
female gonad development GO:0008585 71 0.092
response to reactive oxygen species GO:0000302 56 0.091
positive regulation of bone remodeling GO:0046852 13 0.091
intracellular receptor signaling pathway GO:0030522 74 0.091
cholesterol import GO:0070508 2 0.091
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 52 0.091
intrinsic apoptotic signaling pathway GO:0097193 132 0.091
regulation of cholesterol efflux GO:0010874 13 0.091
white fat cell differentiation GO:0050872 15 0.090
ossification GO:0001503 216 0.090
negative regulation of smooth muscle cell apoptotic process GO:0034392 1 0.090
positive regulation of cell substrate adhesion GO:0010811 47 0.090
rhythmic process GO:0048511 174 0.089
phospholipid efflux GO:0033700 3 0.089
cellular amino acid catabolic process GO:0009063 25 0.089
triglyceride biosynthetic process GO:0019432 17 0.089
cellular response to macrophage colony stimulating factor stimulus GO:0036006 3 0.088
positive regulation of dna biosynthetic process GO:2000573 4 0.088
toxin transport GO:1901998 38 0.087
negative regulation of cholesterol efflux GO:0090370 4 0.087
metanephric glomerulus morphogenesis GO:0072275 3 0.087
chemotaxis GO:0006935 247 0.087
modification of morphology or physiology of other organism involved in symbiotic interaction GO:0051817 16 0.086
negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress GO:1902219 1 0.086
embryonic skeletal system morphogenesis GO:0048704 91 0.086
regulation of defense response GO:0031347 233 0.086
regulation of cytoskeleton organization GO:0051493 122 0.086
tissue remodeling GO:0048771 102 0.085
chromatin modification GO:0016568 187 0.085
cellular homeostasis GO:0019725 240 0.085
negative regulation of protein metabolic process GO:0051248 282 0.084
regulation of protein maturation GO:1903317 96 0.084
angiogenesis involved in coronary vascular morphogenesis GO:0060978 2 0.084
multi multicellular organism process GO:0044706 109 0.083
positive regulation of epithelial cell proliferation GO:0050679 68 0.083
female sex differentiation GO:0046660 84 0.083
ovulation cycle GO:0042698 59 0.083
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.082
regulation of phospholipid transport GO:2001138 4 0.082
regulation of inclusion body assembly GO:0090083 1 0.082
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.082
Mouse
regulation of lipid transport GO:0032368 36 0.081
regulation of phospholipase a2 activity GO:0032429 3 0.080
regulation of lymphocyte differentiation GO:0045619 107 0.080
cellular response to erythropoietin GO:0036018 1 0.080
carbohydrate derivative biosynthetic process GO:1901137 183 0.080
striated muscle contraction GO:0006941 45 0.080
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 34 0.080
fat cell differentiation GO:0045444 160 0.080
lipid storage GO:0019915 36 0.079
nitrogen compound transport GO:0071705 271 0.079
tyrosine phosphorylation of stat3 protein GO:0042503 12 0.079
regulation of membrane protein ectodomain proteolysis GO:0051043 3 0.078
negative regulation of heart rate GO:0010459 4 0.078
alpha amino acid catabolic process GO:1901606 18 0.078
regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis GO:2000150 1 0.078
regulation of muscle system process GO:0090257 80 0.077
negative regulation of peptide secretion GO:0002792 16 0.077
bone development GO:0060348 120 0.077
chromatin organization GO:0006325 206 0.077
carbohydrate metabolic process GO:0005975 230 0.076
i kappab phosphorylation GO:0007252 6 0.076
hair follicle development GO:0001942 85 0.076
morphogenesis of a branching epithelium GO:0061138 193 0.076
regulation of mesenchymal cell proliferation GO:0010464 37 0.076
regulation of protein kinase activity GO:0045859 232 0.076
Mouse
positive regulation of programmed cell death GO:0043068 218 0.076
negative regulation of neurotrophin trk receptor signaling pathway GO:0051387 2 0.075
negative regulation of secretion by cell GO:1903531 54 0.075
cell adhesion GO:0007155 329 0.075
regulation of protein serine threonine kinase activity GO:0071900 157 0.075
epidermal growth factor receptor signaling pathway GO:0007173 28 0.074
regulation of cell motility GO:2000145 236 0.074
negative regulation of hydrolase activity GO:0051346 71 0.074
regulation of peptide hormone secretion GO:0090276 75 0.074
regulation of cell adhesion GO:0030155 154 0.073
ameboidal type cell migration GO:0001667 128 0.073
kit signaling pathway GO:0038109 3 0.072
bmp signaling pathway GO:0030509 93 0.072
cytosolic calcium ion homeostasis GO:0051480 70 0.072
chondrocyte differentiation GO:0002062 72 0.072
low density lipoprotein particle clearance GO:0034383 8 0.072
regulation of blood coagulation GO:0030193 28 0.072
negative regulation of reactive oxygen species biosynthetic process GO:1903427 0 0.072
induction by organism of immune response of other organism involved in symbiotic interaction GO:0052558 1 0.071
response to lipoprotein particle GO:0055094 5 0.071
membrane protein proteolysis GO:0033619 10 0.071
lipid catabolic process GO:0016042 69 0.071
beta amyloid clearance GO:0097242 2 0.071
negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis GO:2000164 1 0.071
endocytosis GO:0006897 168 0.070
negative regulation of defense response GO:0031348 77 0.070
nuclear import GO:0051170 95 0.070
positive regulation of tissue remodeling GO:0034105 19 0.070
regulation of leukocyte differentiation GO:1902105 159 0.070
myeloid cell homeostasis GO:0002262 114 0.069
regulation of cholesterol storage GO:0010885 4 0.069
peptidyl tyrosine modification GO:0018212 145 0.069
Mouse
extrinsic apoptotic signaling pathway GO:0097191 126 0.069
positive regulation of apoptotic signaling pathway GO:2001235 95 0.069
transmembrane transport GO:0055085 412 0.069
humoral immune response GO:0006959 57 0.068
face development GO:0060324 38 0.068
glutamine family amino acid catabolic process GO:0009065 5 0.068
cellular response to thyroid hormone stimulus GO:0097067 1 0.068
regulation of bmp signaling pathway GO:0030510 60 0.068
negative regulation of b cell activation GO:0050869 27 0.068
striated muscle tissue development GO:0014706 293 0.068
metanephric nephron development GO:0072210 34 0.067
response to oxygen levels GO:0070482 62 0.067
Rat
positive regulation of cytokine production GO:0001819 174 0.067
positive regulation of behavior GO:0048520 40 0.067
leukocyte mediated immunity GO:0002443 174 0.067
cellular response to organic cyclic compound GO:0071407 87 0.066
male sex differentiation GO:0046661 109 0.066
heart morphogenesis GO:0003007 178 0.066
connective tissue development GO:0061448 179 0.066
positive regulation of cell migration GO:0030335 109 0.065
endocrine system development GO:0035270 98 0.065
dendritic cell cytokine production GO:0002371 3 0.065
response to bacterial lipoprotein GO:0032493 4 0.065
positive regulation of stem cell proliferation GO:2000648 59 0.065
spermatid development GO:0007286 108 0.065
digestive tract morphogenesis GO:0048546 147 0.064
positive regulation of interferon alpha production GO:0032727 4 0.064
regulation of epithelial cell proliferation GO:0050678 141 0.064
epithelial tube morphogenesis GO:0060562 303 0.064
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.064

Ldlr disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.691
Human
lipid metabolism disorder DOID:3146 0 0.371
Human
inherited metabolic disorder DOID:655 0 0.371
Human
immune system disease DOID:2914 0 0.323
disease of anatomical entity DOID:7 0 0.323
lymphatic system disease DOID:75 0 0.323
disease of mental health DOID:150 0 0.066