Mus musculus

346 known processes

Lep

leptin

(Aliases: obese,ob)

Lep biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of fatty acid oxidation GO:0046320 10 1.000
cellular response to peptide GO:1901653 92 1.000
cellular lipid catabolic process GO:0044242 52 1.000
neuropeptide signaling pathway GO:0007218 19 1.000
monosaccharide metabolic process GO:0005996 106 1.000
regulation of fatty acid metabolic process GO:0019217 28 1.000
regulation of triglyceride metabolic process GO:0090207 17 1.000
acylglycerol metabolic process GO:0006639 55 0.999
regulation of nitrogen cycle metabolic process GO:1903314 1 0.999
hexose metabolic process GO:0019318 98 0.999
response to growth factor GO:0070848 198 0.999
positive regulation of lipid catabolic process GO:0050996 6 0.998
response to peptide hormone GO:0043434 127 0.998
regulation of carbohydrate biosynthetic process GO:0043255 40 0.998
cellular response to insulin stimulus GO:0032869 78 0.998
response to testosterone GO:0033574 3 0.998
positive regulation of fatty acid oxidation GO:0046321 4 0.998
acylglycerol catabolic process GO:0046464 11 0.998
sequestering of triglyceride GO:0030730 6 0.997
regulation of insulin receptor signaling pathway GO:0046626 21 0.996
cellular response to growth factor stimulus GO:0071363 197 0.995
triglyceride metabolic process GO:0006641 51 0.995
cellular carbohydrate metabolic process GO:0044262 119 0.995
negative regulation of lipid catabolic process GO:0050995 6 0.995
cellular lipid metabolic process GO:0044255 323 0.994
rhythmic process GO:0048511 174 0.994
positive regulation of cyclic nucleotide biosynthetic process GO:0030804 24 0.994
drug metabolic process GO:0017144 4 0.994
neutral lipid metabolic process GO:0006638 57 0.994
regulation of carbohydrate metabolic process GO:0006109 75 0.994
regulation of cellular ketone metabolic process GO:0010565 66 0.994
gland development GO:0048732 330 0.993
apoptotic process involved in mammary gland involution GO:0060057 4 0.993
gluconeogenesis GO:0006094 39 0.992
positive regulation of apoptotic process involved in mammary gland involution GO:0060058 4 0.990
adenylate cyclase activating g protein coupled receptor signaling pathway GO:0007189 30 0.990
positive regulation of nucleotide biosynthetic process GO:0030810 26 0.989
organic acid catabolic process GO:0016054 51 0.989
response to nutrient levels GO:0031667 109 0.988
response to bile acid GO:1903412 1 0.988
lipid catabolic process GO:0016042 69 0.987
response to organonitrogen compound GO:0010243 246 0.985
alpha amino acid metabolic process GO:1901605 59 0.985
response to corticosteroid GO:0031960 20 0.983
regulation of glutamine family amino acid metabolic process GO:0000820 1 0.981
response to peptide GO:1901652 136 0.981
glucose metabolic process GO:0006006 92 0.981
fatty acid metabolic process GO:0006631 121 0.980
glycerolipid metabolic process GO:0046486 122 0.977
regulation of gluconeogenesis GO:0006111 30 0.977
epithelial tube morphogenesis GO:0060562 303 0.975
carbohydrate metabolic process GO:0005975 230 0.972
negative regulation of lipid metabolic process GO:0045833 30 0.970
negative regulation of peptide hormone secretion GO:0090278 16 0.970
regulation of lipid catabolic process GO:0050994 15 0.970
positive regulation of triglyceride metabolic process GO:0090208 9 0.970
fatty acid beta oxidation GO:0006635 16 0.970
regulation of cellular carbohydrate metabolic process GO:0010675 75 0.966
response to glucocorticoid GO:0051384 20 0.964
negative regulation of gluconeogenesis GO:0045721 9 0.964
small molecule catabolic process GO:0044282 71 0.963
triglyceride catabolic process GO:0019433 9 0.961
regulation of glucose metabolic process GO:0010906 60 0.961
cellular response to peptide hormone stimulus GO:0071375 92 0.960
fatty acid oxidation GO:0019395 28 0.960
regulation of hormone secretion GO:0046883 88 0.959
response to insulin GO:0032868 100 0.958
cellular amino acid metabolic process GO:0006520 103 0.958
regulation of cellular amine metabolic process GO:0033238 20 0.956
response to organic cyclic compound GO:0014070 198 0.956
monocarboxylic acid catabolic process GO:0072329 27 0.954
nitric oxide mediated signal transduction GO:0007263 4 0.952
regulation of peptide secretion GO:0002791 77 0.951
response to alcohol GO:0097305 48 0.949
positive regulation of apoptotic process GO:0043065 217 0.948
digestion GO:0007586 40 0.942
ammonia assimilation cycle GO:0019676 2 0.942
fatty acid catabolic process GO:0009062 25 0.940
cellular response to transforming growth factor beta stimulus GO:0071560 88 0.940
positive regulation of lipid metabolic process GO:0045834 40 0.939
white fat cell differentiation GO:0050872 15 0.939
regulation of feeding behavior GO:0060259 3 0.936
cellular response to hormone stimulus GO:0032870 150 0.932
regulation of glutamate metabolic process GO:2000211 1 0.932
monosaccharide biosynthetic process GO:0046364 44 0.931
brown fat cell differentiation GO:0050873 36 0.931
positive regulation of insulin receptor signaling pathway GO:0046628 4 0.928
glucose homeostasis GO:0042593 128 0.927
connective tissue development GO:0061448 179 0.924
regulation of the force of heart contraction by chemical signal GO:0003057 5 0.919
organic hydroxy compound metabolic process GO:1901615 203 0.919
regulation of androgen receptor signaling pathway GO:0060765 3 0.919
mammary gland duct morphogenesis GO:0060603 38 0.918
cellular ketone metabolic process GO:0042180 84 0.916
regulation of urea metabolic process GO:0034255 1 0.915
negative regulation of hormone secretion GO:0046888 20 0.909
regulation of vitamin d biosynthetic process GO:0060556 1 0.908
epithelial cell proliferation GO:0050673 174 0.907
regulation of cellular catabolic process GO:0031329 242 0.906
cyclic purine nucleotide metabolic process GO:0052652 43 0.905
regulation of cellular amino acid metabolic process GO:0006521 5 0.904
carbohydrate biosynthetic process GO:0016051 74 0.898
creatinine metabolic process GO:0046449 3 0.897
collagen biosynthetic process GO:0032964 7 0.897
neutral lipid catabolic process GO:0046461 11 0.897
response to transforming growth factor beta GO:0071559 88 0.896
positive regulation of lipid storage GO:0010884 10 0.893
regulation of blood pressure GO:0008217 93 0.890
g protein coupled receptor signaling pathway GO:0007186 243 0.889
drug catabolic process GO:0042737 2 0.887
tertiary branching involved in mammary gland duct morphogenesis GO:0060748 3 0.886
multicellular organism growth GO:0035264 161 0.886
glutamine family amino acid metabolic process GO:0009064 15 0.885
glutamate metabolic process GO:0006536 9 0.885
negative regulation of androgen receptor signaling pathway GO:0060766 3 0.884
succinate metabolic process GO:0006105 4 0.877
g protein coupled receptor internalization GO:0002031 3 0.875
regulation of chromatin modification GO:1903308 57 0.875
regulation of ammonia assimilation cycle GO:2001248 1 0.869
regulation of secretion by cell GO:1903530 249 0.867
circadian rhythm GO:0007623 114 0.867
steroid metabolic process GO:0008202 119 0.865
morphogenesis of a branching structure GO:0001763 203 0.865
regulation of camp metabolic process GO:0030814 30 0.865
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.859
regulation of mast cell differentiation GO:0060375 3 0.858
positive regulation of programmed cell death GO:0043068 218 0.856
phospholipase c activating g protein coupled receptor signaling pathway GO:0007200 26 0.855
regulation of response to food GO:0032095 10 0.855
cell adhesion GO:0007155 329 0.843
ovulation from ovarian follicle GO:0001542 9 0.842
positive regulation of fatty acid metabolic process GO:0045923 8 0.842
vasoconstriction GO:0042310 27 0.836
dna metabolic process GO:0006259 303 0.831
regulation of lipid storage GO:0010883 20 0.831
adenylate cyclase modulating g protein coupled receptor signaling pathway GO:0007188 54 0.827
insulin receptor signaling pathway GO:0008286 49 0.819
keratinocyte migration GO:0051546 3 0.816
peptide secretion GO:0002790 114 0.799
exogenous drug catabolic process GO:0042738 1 0.798
regulation of fatty acid beta oxidation GO:0031998 1 0.798
regulation of peptide transport GO:0090087 91 0.796
positive regulation of mapk cascade GO:0043410 170 0.794
cellular chemical homeostasis GO:0055082 215 0.793
multicellular organismal homeostasis GO:0048871 164 0.792
cellular calcium ion homeostasis GO:0006874 119 0.790
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger GO:0007187 55 0.785
cellular response to cytokine stimulus GO:0071345 189 0.783
negative regulation of cellular carbohydrate metabolic process GO:0010677 19 0.783
amide transport GO:0042886 138 0.782
regulation of organelle organization GO:0033043 289 0.777
developmental maturation GO:0021700 193 0.776
peptide transport GO:0015833 133 0.770
positive regulation of triglyceride catabolic process GO:0010898 3 0.770
circulatory system process GO:0003013 197 0.770
response to corticosterone GO:0051412 1 0.767
carbohydrate homeostasis GO:0033500 128 0.765
lactation GO:0007595 25 0.764
internal protein amino acid acetylation GO:0006475 42 0.761
lipid localization GO:0010876 126 0.761
long chain fatty acid transport GO:0015909 15 0.760
chromatin modification GO:0016568 187 0.758
lipid transport GO:0006869 98 0.758
dicarboxylic acid metabolic process GO:0043648 18 0.757
associative learning GO:0008306 61 0.755
positive regulation of carbohydrate metabolic process GO:0045913 30 0.753
multicellular organismal response to stress GO:0033555 62 0.752
regulation of lipid metabolic process GO:0019216 118 0.749
glycerolipid catabolic process GO:0046503 16 0.745
amine metabolic process GO:0009308 45 0.745
synaptic transmission GO:0007268 329 0.743
forebrain development GO:0030900 302 0.742
peptidyl amino acid modification GO:0018193 336 0.740
cellular response to prostaglandin stimulus GO:0071379 2 0.738
cellular amine metabolic process GO:0044106 44 0.735
cartilage development GO:0051216 140 0.733
positive regulation of secretion GO:0051047 130 0.733
mammary gland lobule development GO:0061377 22 0.733
negative regulation of triglyceride metabolic process GO:0090209 4 0.729
response to extracellular stimulus GO:0009991 127 0.729
branching involved in mammary gland duct morphogenesis GO:0060444 27 0.728
positive regulation of inositol phosphate biosynthetic process GO:0060732 2 0.726
negative regulation of insulin secretion GO:0046676 14 0.726
regulation of circadian rhythm GO:0042752 58 0.720
ribose phosphate biosynthetic process GO:0046390 59 0.719
positive regulation of cellular amine metabolic process GO:0033240 5 0.716
transforming growth factor beta receptor signaling pathway GO:0007179 71 0.711
regulation of cell migration GO:0030334 219 0.710
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.706
hormone secretion GO:0046879 128 0.706
negative regulation of peptide secretion GO:0002792 16 0.704
cognition GO:0050890 149 0.703
positive regulation of peptide secretion GO:0002793 33 0.697
regulation of leukocyte differentiation GO:1902105 159 0.695
purine nucleotide biosynthetic process GO:0006164 65 0.692
regulation of peptide hormone secretion GO:0090276 75 0.692
ossification GO:0001503 216 0.690
positive regulation of chromosome organization GO:2001252 33 0.689
cholesterol storage GO:0010878 4 0.673
divalent metal ion transport GO:0070838 172 0.672
regulation of reactive oxygen species biosynthetic process GO:1903426 2 0.671
intracellular receptor signaling pathway GO:0030522 74 0.666
long term synaptic potentiation GO:0060291 25 0.658
positive regulation of apoptotic process involved in morphogenesis GO:1902339 4 0.653
insulin secretion GO:0030073 89 0.650
response to ketone GO:1901654 15 0.649
mammary gland epithelium development GO:0061180 65 0.647
positive regulation of camp metabolic process GO:0030816 19 0.646
regulation of sequestering of triglyceride GO:0010889 6 0.642
internal peptidyl lysine acetylation GO:0018393 42 0.637
hormone metabolic process GO:0042445 86 0.636
regulation of epithelial cell proliferation GO:0050678 141 0.635
positive regulation of glucose metabolic process GO:0010907 21 0.635
peptide hormone secretion GO:0030072 109 0.626
divalent inorganic cation homeostasis GO:0072507 138 0.617
cellular response to prostaglandin e stimulus GO:0071380 1 0.616
catecholamine metabolic process GO:0006584 30 0.615
regulation of system process GO:0044057 200 0.610
response to steroid hormone GO:0048545 56 0.607
positive regulation of camp mediated signaling GO:0043950 3 0.602
regulation of hormone levels GO:0010817 211 0.601
calcium ion transport GO:0006816 159 0.600
developmental programmed cell death GO:0010623 41 0.598
response to increased oxygen levels GO:0036296 2 0.596
regulation of serotonin uptake GO:0051611 2 0.595
regulation of histone acetylation GO:0035065 19 0.593
regulation of nucleotide biosynthetic process GO:0030808 34 0.591
positive regulation of chromatin modification GO:1903310 28 0.589
cellular response to vitamin GO:0071295 2 0.586
oxidation reduction process GO:0055114 342 0.580
response to dexamethasone GO:0071548 8 0.579
odontogenesis GO:0042476 78 0.579
cellular response to organonitrogen compound GO:0071417 145 0.576
defense response to other organism GO:0098542 197 0.575
hexose biosynthetic process GO:0019319 39 0.573
regulation of metal ion transport GO:0010959 106 0.573
regulation of the force of heart contraction GO:0002026 17 0.567
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 68 0.566
positive regulation of cellular catabolic process GO:0031331 148 0.565
response to food GO:0032094 17 0.564
asymmetric stem cell division GO:0098722 3 0.564
cellular response to bile acid GO:1903413 1 0.561
regulation of triglyceride catabolic process GO:0010896 5 0.560
negative regulation of interferon gamma mediated signaling pathway GO:0060336 1 0.559
positive regulation of glial cell proliferation GO:0060252 4 0.559
vitamin d biosynthetic process GO:0042368 3 0.558
positive regulation of apoptotic signaling pathway GO:2001235 95 0.557
regulation of monooxygenase activity GO:0032768 7 0.556
fatty acid transport GO:0015908 28 0.556
development of secondary male sexual characteristics GO:0046544 3 0.555
mapk cascade GO:0000165 281 0.553
female gonad development GO:0008585 71 0.552
regulation of chromosome organization GO:0033044 83 0.544
regulation of carbohydrate catabolic process GO:0043470 12 0.539
purine nucleotide metabolic process GO:0006163 302 0.538
nuclear transport GO:0051169 139 0.537
positive regulation of cell development GO:0010720 237 0.537
acid secretion GO:0046717 33 0.537
taurine metabolic process GO:0019530 4 0.535
carboxylic acid catabolic process GO:0046395 51 0.535
positive regulation of cell death GO:0010942 224 0.531
negative regulation of cellular response to insulin stimulus GO:1900077 16 0.530
positive regulation of peptide hormone secretion GO:0090277 31 0.526
regulation of kinase activity GO:0043549 249 0.521
lipid particle organization GO:0034389 7 0.519
negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 26 0.517
g protein coupled receptor signaling pathway involved in heart process GO:0086103 4 0.514
peptidyl lysine acetylation GO:0018394 45 0.510
positive regulation of exit from mitosis GO:0031536 1 0.510
epidermis development GO:0008544 187 0.509
nucleotide biosynthetic process GO:0009165 78 0.509
response to activity GO:0014823 13 0.507
cellular response to vitamin d GO:0071305 2 0.494
cholesterol metabolic process GO:0008203 56 0.494
fat soluble vitamin biosynthetic process GO:0042362 4 0.493
astrocyte fate commitment GO:0060018 4 0.493
cellular glucan metabolic process GO:0006073 32 0.492
camp biosynthetic process GO:0006171 31 0.491
cellular carbohydrate catabolic process GO:0044275 15 0.490
jak stat cascade GO:0007259 42 0.482
protein nitrosylation GO:0017014 4 0.481
reactive nitrogen species metabolic process GO:2001057 0 0.481
positive regulation of intracellular estrogen receptor signaling pathway GO:0033148 4 0.481
response to ammonium ion GO:0060359 21 0.480
cation transport GO:0006812 399 0.480
adenylate cyclase inhibiting g protein coupled receptor signaling pathway GO:0007193 20 0.479
regulation of leukocyte apoptotic process GO:2000106 56 0.478
leukocyte apoptotic process GO:0071887 71 0.476
histone acetylation GO:0016573 41 0.475
hair follicle development GO:0001942 85 0.470
negative regulation of molecular function GO:0044092 258 0.468
negative regulation of secretion by cell GO:1903531 54 0.467
triglyceride mobilization GO:0006642 5 0.464
ribonucleotide metabolic process GO:0009259 291 0.464
second messenger mediated signaling GO:0019932 73 0.461
negative regulation of sequestering of triglyceride GO:0010891 2 0.459
protein localization to organelle GO:0033365 185 0.457
hormone mediated apoptotic signaling pathway GO:0008628 1 0.455
regulation of glycogen metabolic process GO:0070873 13 0.453
divalent inorganic cation transport GO:0072511 178 0.453
cellular metal ion homeostasis GO:0006875 151 0.451
response to lipopolysaccharide GO:0032496 128 0.451
regulation of vasoconstriction GO:0019229 14 0.450
aromatic compound catabolic process GO:0019439 286 0.448
allantoin metabolic process GO:0000255 3 0.448
heterocycle catabolic process GO:0046700 280 0.447
locomotory behavior GO:0007626 195 0.445
glucose import GO:0046323 32 0.443
phenol containing compound biosynthetic process GO:0046189 21 0.441
cellular response to external stimulus GO:0071496 88 0.441
regulation of exit from mitosis GO:0007096 1 0.441
negative regulation of carbohydrate metabolic process GO:0045912 19 0.440
citrate metabolic process GO:0006101 3 0.440
branching morphogenesis of an epithelial tube GO:0048754 159 0.439
male anatomical structure morphogenesis GO:0090598 4 0.438
trophectodermal cell proliferation GO:0001834 2 0.438
mammary gland branching involved in pregnancy GO:0060745 6 0.436
cell proliferation in hindbrain GO:0021534 10 0.433
bone development GO:0060348 120 0.431
response to pain GO:0048265 26 0.430
response to ethanol GO:0045471 18 0.430
negative regulation of reactive oxygen species biosynthetic process GO:1903427 0 0.427
energy reserve metabolic process GO:0006112 39 0.423
polysaccharide metabolic process GO:0005976 39 0.421
regulation of blood vessel size GO:0050880 56 0.417
apoptotic process involved in development GO:1902742 28 0.417
regulation of cell motility GO:2000145 236 0.416
lipid oxidation GO:0034440 29 0.415
ribonucleotide biosynthetic process GO:0009260 59 0.412
positive regulation of histone modification GO:0031058 28 0.412
cellular divalent inorganic cation homeostasis GO:0072503 127 0.412
antral ovarian follicle growth GO:0001547 5 0.409
myeloid cell differentiation GO:0030099 233 0.409
monocarboxylic acid metabolic process GO:0032787 191 0.408
urogenital system development GO:0001655 261 0.408
purine nucleoside metabolic process GO:0042278 241 0.406
metal ion homeostasis GO:0055065 189 0.404
response to decreased oxygen levels GO:0036293 59 0.403
cellular response to inorganic substance GO:0071241 37 0.401
regulation of secretion GO:0051046 274 0.399
regulation of glucocorticoid secretion GO:2000849 5 0.398
response to lithium ion GO:0010226 10 0.398
regulation of hydrolase activity GO:0051336 246 0.391
regulation of histone modification GO:0031056 56 0.389
glycolytic process GO:0006096 20 0.389
response to amphetamine GO:0001975 16 0.388
histone modification GO:0016570 159 0.388
stem cell development GO:0048864 219 0.381
negative regulation of release of cytochrome c from mitochondria GO:0090201 6 0.381
response to cocaine GO:0042220 14 0.376
neuron migration GO:0001764 122 0.375
regulation of ion transport GO:0043269 215 0.374
regulation of camp mediated signaling GO:0043949 7 0.373
response to hyperoxia GO:0055093 2 0.371
regulation of calcidiol 1 monooxygenase activity GO:0060558 1 0.370
ensheathment of neurons GO:0007272 76 0.370
skeletal system development GO:0001501 356 0.368
positive regulation of insulin secretion GO:0032024 26 0.363
response to metal ion GO:0010038 47 0.362
morphogenesis of a branching epithelium GO:0061138 193 0.361
positive regulation of mammary gland involution GO:1903521 4 0.361
glycogen metabolic process GO:0005977 32 0.360
lipid biosynthetic process GO:0008610 179 0.359
regulation of nucleotide metabolic process GO:0006140 169 0.357
nucleobase containing small molecule metabolic process GO:0055086 352 0.356
response to vitamin a GO:0033189 1 0.354
trophectodermal cellular morphogenesis GO:0001831 3 0.354
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.353
purine containing compound metabolic process GO:0072521 311 0.352
anatomical structure homeostasis GO:0060249 145 0.352
maintenance of location GO:0051235 89 0.351
cell growth GO:0016049 130 0.350
cellular macromolecule catabolic process GO:0044265 206 0.349
regulation of lymphocyte activation GO:0051249 240 0.346
inflammatory response GO:0006954 244 0.346
hormone mediated signaling pathway GO:0009755 23 0.346
purine containing compound biosynthetic process GO:0072522 70 0.345
multicellular organismal metabolic process GO:0044236 28 0.344
regulation of mammary gland involution GO:1903519 4 0.344
primary ovarian follicle growth GO:0001545 2 0.344
calcium ion homeostasis GO:0055074 127 0.343
cellular response to steroid hormone stimulus GO:0071383 33 0.342
regulation of purine nucleotide biosynthetic process GO:1900371 34 0.342
regulation of apoptotic signaling pathway GO:2001233 197 0.341
fear response GO:0042596 33 0.340
triglyceride biosynthetic process GO:0019432 17 0.338
prostate gland growth GO:0060736 13 0.338
regulation of steroid biosynthetic process GO:0050810 26 0.338
bone morphogenesis GO:0060349 78 0.337
cytokine mediated signaling pathway GO:0019221 115 0.337
blood circulation GO:0008015 195 0.336
mammary gland morphogenesis GO:0060443 54 0.335
positive regulation of nervous system development GO:0051962 221 0.335
learning GO:0007612 98 0.333
cellular ion homeostasis GO:0006873 165 0.332
response to monosaccharide GO:0034284 67 0.331
regulation of mapk cascade GO:0043408 248 0.331
purine ribonucleotide metabolic process GO:0009150 290 0.329
energy derivation by oxidation of organic compounds GO:0015980 77 0.329
spinal cord development GO:0021510 81 0.327
regulation of cyclic nucleotide biosynthetic process GO:0030802 31 0.325
ovulation cycle GO:0042698 59 0.323
urea metabolic process GO:0019627 3 0.323
positive regulation of cyclic nucleotide metabolic process GO:0030801 24 0.318
acylglycerol biosynthetic process GO:0046463 18 0.318
lymphocyte differentiation GO:0030098 242 0.318
response to phenylpropanoid GO:0080184 22 0.318
diacylglycerol metabolic process GO:0046339 6 0.316
positive regulation of cytosolic calcium ion concentration GO:0007204 65 0.314
cation homeostasis GO:0055080 212 0.314
smooth muscle contraction GO:0006939 44 0.308
eating behavior GO:0042755 15 0.307
sterol metabolic process GO:0016125 58 0.304
corticosterone secretion GO:0035934 3 0.303
response to interferon gamma GO:0034341 34 0.303
regulation of steroid hormone biosynthetic process GO:0090030 4 0.301
digestive tract development GO:0048565 190 0.301
negative regulation of cytokine production GO:0001818 84 0.300
type b pancreatic cell proliferation GO:0044342 10 0.299
regulation of histone deacetylation GO:0031063 12 0.298
positive regulation of protein modification process GO:0031401 299 0.297
intracellular steroid hormone receptor signaling pathway GO:0030518 29 0.297
temperature homeostasis GO:0001659 26 0.295
cellular response to glucose stimulus GO:0071333 45 0.295
organonitrogen compound biosynthetic process GO:1901566 192 0.290
phosphatidylinositol 3 kinase signaling GO:0014065 36 0.288
response to oxygen levels GO:0070482 62 0.288
cellular response to metal ion GO:0071248 31 0.286
wnt signaling pathway involved in kidney development GO:0061289 2 0.285
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.285
regulation of peptidyl lysine acetylation GO:2000756 22 0.284
alcohol metabolic process GO:0006066 116 0.282
positive regulation of sodium ion transmembrane transport GO:1902307 4 0.281
regulation of multicellular organismal metabolic process GO:0044246 14 0.279
positive regulation of vasoconstriction GO:0045907 4 0.278
steroid hormone mediated signaling pathway GO:0043401 6 0.274
negative regulation of cell proliferation GO:0008285 296 0.272
regulation of osteoblast differentiation GO:0045667 67 0.271
ribose phosphate metabolic process GO:0019693 291 0.271
response to estrogen GO:0043627 24 0.269
regulation of stem cell proliferation GO:0072091 78 0.268
regulation of transmembrane transport GO:0034762 128 0.268
positive regulation of sodium ion transport GO:0010765 13 0.266
intestinal absorption GO:0050892 13 0.265
positive regulation of cellular response to insulin stimulus GO:1900078 9 0.265
hair cycle GO:0042633 90 0.265
response to drug GO:0042493 75 0.263
regulation of phosphatidylinositol 3 kinase signaling GO:0014066 30 0.263
prostate epithelial cord elongation GO:0060523 3 0.260
negative regulation of muscle adaptation GO:0014745 2 0.260
covalent chromatin modification GO:0016569 163 0.259
carbohydrate catabolic process GO:0016052 32 0.258
multicellular organismal signaling GO:0035637 91 0.257
regulation of saliva secretion GO:0046877 2 0.256
renal system development GO:0072001 225 0.256
peptidyl cysteine modification GO:0018198 8 0.255
positive regulation of behavior GO:0048520 40 0.255
cytosolic calcium ion homeostasis GO:0051480 70 0.254
carbohydrate derivative biosynthetic process GO:1901137 183 0.253
organic hydroxy compound biosynthetic process GO:1901617 77 0.253
platelet derived growth factor receptor signaling pathway GO:0048008 32 0.253
response to low density lipoprotein particle GO:0055098 2 0.250
catecholamine uptake involved in synaptic transmission GO:0051934 4 0.249
cell cell signaling involved in metanephros development GO:0072204 2 0.248
hemangioblast cell differentiation GO:0060217 1 0.247
negative regulation of execution phase of apoptosis GO:1900118 4 0.242
multicellular organismal macromolecule metabolic process GO:0044259 19 0.242
response to morphine GO:0043278 9 0.242
regulation of sodium ion transport GO:0002028 29 0.242
purine ribonucleotide biosynthetic process GO:0009152 59 0.241
negative regulation of kinase activity GO:0033673 81 0.241
visceral serous pericardium development GO:0061032 2 0.239
positive regulation of hormone secretion GO:0046887 38 0.239
tissue remodeling GO:0048771 102 0.239
guanosine containing compound metabolic process GO:1901068 144 0.238
response to inorganic substance GO:0010035 96 0.238
positive regulation of erk1 and erk2 cascade GO:0070374 47 0.236
negative regulation of nervous system development GO:0051961 156 0.236
negative regulation of neurotransmitter uptake GO:0051581 2 0.234
calcium ion transport into cytosol GO:0060402 48 0.234
regulation of calcium ion transport GO:0051924 69 0.233
body fluid secretion GO:0007589 53 0.233
lateral line system development GO:0048925 1 0.232
regulation of myeloid cell differentiation GO:0045637 96 0.232
response to estradiol GO:0032355 12 0.231
positive regulation of transferase activity GO:0051347 167 0.229
regulation of neuron death GO:1901214 134 0.229
regulation of lymphocyte proliferation GO:0050670 117 0.228
arginine metabolic process GO:0006525 2 0.226
regulation of adrenergic receptor signaling pathway GO:0071877 4 0.225

Lep disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.948
diabetes mellitus DOID:9351 0 0.944
type 2 diabetes mellitus DOID:9352 0 0.944
carbohydrate metabolism disease DOID:0050013 0 0.944
glucose metabolism disease DOID:4194 0 0.944
acquired metabolic disease DOID:0060158 0 0.944
nutrition disease DOID:374 0 0.672
overnutrition DOID:654 0 0.672
inherited metabolic disorder DOID:655 0 0.445