Mus musculus

40 known processes

Lig1

ligase I, DNA, ATP-dependent

(Aliases: LigI,AL033288)

Lig1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
dna metabolic process GO:0006259 303 0.907
dna replication GO:0006260 52 0.813
meiosis i GO:0007127 60 0.690
cellular response to dna damage stimulus GO:0006974 207 0.660
dna recombination GO:0006310 92 0.655
dna dependent dna replication GO:0006261 24 0.641
regulation of mitotic cell cycle phase transition GO:1901990 73 0.619
recombinational repair GO:0000725 21 0.549
mitotic cell cycle GO:0000278 195 0.484
purine nucleoside catabolic process GO:0006152 205 0.482
dna repair GO:0006281 107 0.466
double strand break repair via homologous recombination GO:0000724 21 0.443
nuclear dna replication GO:0033260 3 0.429
dna unwinding involved in dna replication GO:0006268 5 0.427
chromatin organization GO:0006325 206 0.389
mitotic cell cycle process GO:1903047 159 0.377
dna endoreduplication GO:0042023 4 0.374
chromosome segregation GO:0007059 48 0.309
organelle fission GO:0048285 170 0.304
translesion synthesis GO:0019985 1 0.293
nucleobase containing small molecule metabolic process GO:0055086 352 0.277
dna dependent dna replication maintenance of fidelity GO:0045005 3 0.274
meiotic nuclear division GO:0007126 115 0.266
double strand break repair GO:0006302 48 0.257
cell cell signaling involved in cell fate commitment GO:0045168 35 0.242
regulation of cell cycle phase transition GO:1901987 77 0.230
lateral inhibition GO:0046331 1 0.229
cellular nitrogen compound catabolic process GO:0044270 280 0.226
meiotic cell cycle GO:0051321 122 0.220
meiotic cell cycle process GO:1903046 77 0.217
negative regulation of mitotic cell cycle GO:0045930 58 0.216
regulation of transcription by chromatin organization GO:0034401 0 0.213
regulation of cell cycle GO:0051726 281 0.192
mitotic sister chromatid segregation GO:0000070 14 0.186
gene silencing GO:0016458 38 0.173
regulation of cellular catabolic process GO:0031329 242 0.172
intra s dna damage checkpoint GO:0031573 4 0.168
regulation of cell cycle process GO:0010564 160 0.162
purine nucleoside triphosphate metabolic process GO:0009144 226 0.151
nuclear division GO:0000280 158 0.148
development of primary sexual characteristics GO:0045137 143 0.147
regulation of mitotic cell cycle GO:0007346 126 0.144
mitotic sister chromatid cohesion GO:0007064 1 0.139
purine containing compound metabolic process GO:0072521 311 0.132
purine ribonucleoside metabolic process GO:0046128 241 0.126
organic cyclic compound catabolic process GO:1901361 295 0.111
aromatic compound catabolic process GO:0019439 286 0.108
methylation GO:0032259 134 0.107
regulation of cell cycle g2 m phase transition GO:1902749 10 0.106
ribonucleotide metabolic process GO:0009259 291 0.103
nucleoside phosphate metabolic process GO:0006753 338 0.095
endocytosis GO:0006897 168 0.095
Worm
negative regulation of gene expression epigenetic GO:0045814 15 0.094
microtubule based process GO:0007017 236 0.093
sister chromatid cohesion GO:0007062 12 0.092
g1 s transition of mitotic cell cycle GO:0000082 57 0.092
gonad development GO:0008406 141 0.091
cellular amino acid metabolic process GO:0006520 103 0.088
microtubule cytoskeleton organization GO:0000226 157 0.088
dna hypermethylation GO:0044026 3 0.087
meiotic chromosome condensation GO:0010032 3 0.084
purine ribonucleotide catabolic process GO:0009154 208 0.084
nucleoside monophosphate metabolic process GO:0009123 85 0.083
atp catabolic process GO:0006200 55 0.082
protein dna complex subunit organization GO:0071824 28 0.082
mitotic cell cycle checkpoint GO:0007093 31 0.082
negative regulation of cellular protein metabolic process GO:0032269 247 0.081
dna conformation change GO:0071103 37 0.079
nucleoside phosphate catabolic process GO:1901292 222 0.077
purine containing compound catabolic process GO:0072523 213 0.076
heterocycle catabolic process GO:0046700 280 0.076
reciprocal meiotic recombination GO:0007131 16 0.076
chromatin modification GO:0016568 187 0.075
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.073
dna integrity checkpoint GO:0031570 28 0.073
inner cell mass cell proliferation GO:0001833 15 0.070
nucleoside metabolic process GO:0009116 246 0.070
cell cycle g1 s phase transition GO:0044843 57 0.069
negative regulation of mitotic cell cycle phase transition GO:1901991 45 0.069
chromosome organization involved in meiosis GO:0070192 39 0.068
purine ribonucleotide metabolic process GO:0009150 290 0.068
regulation of chromosome organization GO:0033044 83 0.067
regulation of protein transport GO:0051223 163 0.066
negative regulation of chromatin silencing GO:0031936 1 0.066
cell cycle checkpoint GO:0000075 47 0.066
ribonucleotide catabolic process GO:0009261 208 0.065
nucleotide metabolic process GO:0009117 332 0.065
sister chromatid segregation GO:0000819 20 0.063
macromolecule catabolic process GO:0009057 281 0.062
intrinsic apoptotic signaling pathway GO:0097193 132 0.060
ribonucleoside triphosphate catabolic process GO:0009203 199 0.060
covalent chromatin modification GO:0016569 163 0.058
base excision repair GO:0006284 9 0.057
organonitrogen compound catabolic process GO:1901565 264 0.057
purine nucleotide metabolic process GO:0006163 302 0.057
glycosyl compound metabolic process GO:1901657 246 0.055
protein maturation GO:0051604 176 0.055
nucleoside catabolic process GO:0009164 206 0.054
dna geometric change GO:0032392 7 0.053
female gamete generation GO:0007292 74 0.053
regulation of attachment of spindle microtubules to kinetochore GO:0051988 3 0.053
negative regulation of cell cycle phase transition GO:1901988 48 0.053
mitotic chromosome condensation GO:0007076 1 0.052
macromolecule methylation GO:0043414 120 0.052
protein modification by small protein conjugation or removal GO:0070647 207 0.051
regulation of hydrolase activity GO:0051336 246 0.050
intracellular protein transport GO:0006886 204 0.050
rna dependent dna replication GO:0006278 3 0.050
purine ribonucleoside catabolic process GO:0046130 205 0.049
negative regulation of cell cycle GO:0045786 123 0.049
organophosphate catabolic process GO:0046434 232 0.048
protein processing GO:0016485 163 0.047
response to radiation GO:0009314 165 0.047
regulation of dna dependent dna replication initiation GO:0030174 3 0.046
negative regulation of protein metabolic process GO:0051248 282 0.045
spindle assembly involved in female meiosis GO:0007056 3 0.044
cellular amine metabolic process GO:0044106 44 0.044
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.043
protein methylation GO:0006479 81 0.042
amine metabolic process GO:0009308 45 0.042
protein ubiquitination GO:0016567 171 0.042
ribonucleoside metabolic process GO:0009119 245 0.042
response to inorganic substance GO:0010035 96 0.042
nucleotide catabolic process GO:0009166 217 0.041
cellular ketone metabolic process GO:0042180 84 0.041
purine ribonucleoside monophosphate catabolic process GO:0009169 57 0.041
regulation of cellular response to stress GO:0080135 159 0.040
nucleoside triphosphate metabolic process GO:0009141 230 0.040
cellular protein catabolic process GO:0044257 155 0.039
membrane organization GO:0061024 245 0.039
histone methylation GO:0016571 71 0.039
reciprocal dna recombination GO:0035825 16 0.038
oxidation reduction process GO:0055114 342 0.038
heterochromatin organization GO:0070828 4 0.037
double strand break repair via nonhomologous end joining GO:0006303 10 0.035
positive regulation of cellular amine metabolic process GO:0033240 5 0.034
germ cell development GO:0007281 185 0.034
nucleoside monophosphate catabolic process GO:0009125 59 0.034
regulation of cellular amino acid metabolic process GO:0006521 5 0.033
purine nucleoside monophosphate catabolic process GO:0009128 58 0.033
dna damage checkpoint GO:0000077 26 0.033
ribose phosphate metabolic process GO:0019693 291 0.033
protein heterotetramerization GO:0051290 4 0.033
cell cycle g2 m phase transition GO:0044839 20 0.033
nitrogen compound transport GO:0071705 271 0.033
anion homeostasis GO:0055081 16 0.032
carbohydrate derivative catabolic process GO:1901136 231 0.032
negative regulation of gene silencing GO:0060969 2 0.032
female meiotic division GO:0007143 21 0.031
cell fate commitment GO:0045165 210 0.031
spermatogenesis GO:0007283 284 0.031
organism emergence from protective structure GO:0071684 4 0.031
camera type eye development GO:0043010 266 0.031
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.030
regulation of secretion by cell GO:1903530 249 0.030
regulation of secretion GO:0051046 274 0.030
regulation of cellular amine metabolic process GO:0033238 20 0.030
cellularization GO:0007349 1 0.030
negative regulation of cell proliferation GO:0008285 296 0.030
regulation of protein localization GO:0032880 231 0.030
deoxyribonucleotide biosynthetic process GO:0009263 6 0.030
negative regulation of atpase activity GO:0032780 2 0.029
negative regulation of protein phosphorylation GO:0001933 126 0.029
receptor mediated endocytosis GO:0006898 51 0.029
Worm
positive regulation of cellular catabolic process GO:0031331 148 0.028
dna replication initiation GO:0006270 5 0.028
regulation of g2 m transition of mitotic cell cycle GO:0010389 10 0.028
cell type specific apoptotic process GO:0097285 268 0.028
negative regulation of nucleoside metabolic process GO:0045978 11 0.028
ribonucleoside triphosphate metabolic process GO:0009199 220 0.028
anatomical structure homeostasis GO:0060249 145 0.028
positive regulation of cell cycle GO:0045787 92 0.027
digestive system development GO:0055123 200 0.027
response to organic cyclic compound GO:0014070 198 0.027
negative regulation of protein modification process GO:0031400 163 0.027
mitotic nuclear division GO:0007067 48 0.027
chromatin silencing GO:0006342 15 0.027
response to organonitrogen compound GO:0010243 246 0.025
apoptotic signaling pathway GO:0097190 306 0.025
cytokinesis GO:0000910 17 0.025
purine nucleoside triphosphate catabolic process GO:0009146 203 0.025
microtubule cytoskeleton organization involved in mitosis GO:1902850 4 0.025
neuron apoptotic process GO:0051402 142 0.025
negative regulation of transcription involved in g1 s transition of mitotic cell cycle GO:0071930 1 0.025
regulation of neuron apoptotic process GO:0043523 122 0.025
positive regulation of mitotic sister chromatid separation GO:1901970 2 0.024
nucleoside triphosphate catabolic process GO:0009143 205 0.024
regulation of cytoplasmic transport GO:1903649 112 0.024
cellular response to cytokine stimulus GO:0071345 189 0.024
intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 19 0.024
regulation of transferase activity GO:0051338 263 0.023
positive regulation of organelle organization GO:0010638 128 0.023
regulation of organelle organization GO:0033043 289 0.023
dna duplex unwinding GO:0032508 7 0.023
ribonucleoside monophosphate metabolic process GO:0009161 80 0.023
cellular homeostasis GO:0019725 240 0.023
positive regulation of protein modification process GO:0031401 299 0.022
regulation of kinase activity GO:0043549 249 0.022
regulation of dna dependent dna replication GO:0090329 8 0.022
purine nucleoside metabolic process GO:0042278 241 0.022
positive regulation of protein kinase activity GO:0045860 144 0.022
male gamete generation GO:0048232 285 0.022
spindle midzone assembly GO:0051255 1 0.022
asymmetric stem cell division GO:0098722 3 0.022
response to ionizing radiation GO:0010212 42 0.022
fertilization GO:0009566 127 0.021
response to light stimulus GO:0009416 135 0.021
positive regulation of cell death GO:0010942 224 0.021
regulation of cellular ketone metabolic process GO:0010565 66 0.021
neuron death GO:0070997 154 0.021
organelle localization GO:0051640 179 0.021
ribonucleoside catabolic process GO:0042454 206 0.021
cellular response to organonitrogen compound GO:0071417 145 0.021
nucleus organization GO:0006997 45 0.021
regulation of nucleotide metabolic process GO:0006140 169 0.020
negative regulation of proteolysis GO:0045861 74 0.020
chromosome separation GO:0051304 14 0.020
small gtpase mediated signal transduction GO:0007264 97 0.020
stem cell proliferation GO:0072089 117 0.020
mitotic cytokinesis GO:0000281 4 0.020
hatching GO:0035188 4 0.020
microtubule organizing center organization GO:0031023 28 0.020
signal transduction by p53 class mediator GO:0072331 51 0.020
protein localization to organelle GO:0033365 185 0.020
cofactor metabolic process GO:0051186 80 0.019
maintenance of location GO:0051235 89 0.019
positive regulation of apoptotic process GO:0043065 217 0.019
regulation of response to dna damage stimulus GO:2001020 34 0.019
glycosyl compound catabolic process GO:1901658 206 0.019
negative regulation of protein processing GO:0010955 79 0.019
positive regulation of histone modification GO:0031058 28 0.019
b cell activation GO:0042113 161 0.018
dna methylation GO:0006306 43 0.018
cell division GO:0051301 120 0.018
atp metabolic process GO:0046034 75 0.018
negative regulation of histone h3 k9 methylation GO:0051573 4 0.018
gland development GO:0048732 330 0.018
dna biosynthetic process GO:0071897 22 0.018
regulation of purine nucleotide metabolic process GO:1900542 169 0.018
regulation of nucleotide catabolic process GO:0030811 122 0.018
regulation of protein kinase activity GO:0045859 232 0.018
digestive tract morphogenesis GO:0048546 147 0.018
negative regulation of cell cycle process GO:0010948 69 0.018
positive regulation of protein phosphorylation GO:0001934 242 0.018
peptide transport GO:0015833 133 0.018
type b pancreatic cell proliferation GO:0044342 10 0.018
response to purine containing compound GO:0014074 28 0.018
s adenosylhomocysteine metabolic process GO:0046498 1 0.018
regulation of defense response GO:0031347 233 0.017
regulation of neuron death GO:1901214 134 0.017
oogenesis GO:0048477 56 0.017
g2 m transition of mitotic cell cycle GO:0000086 20 0.017
cellular macromolecule catabolic process GO:0044265 206 0.017
regulation of protein maturation GO:1903317 96 0.017
amide transport GO:0042886 138 0.017
sensory organ morphogenesis GO:0090596 242 0.017
inflammatory response GO:0006954 244 0.017
sulfur compound metabolic process GO:0006790 100 0.017
regulation of cellular component biogenesis GO:0044087 181 0.017
regulation of inflammatory response GO:0050727 147 0.016
regulation of intracellular transport GO:0032386 159 0.016
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 62 0.016
alpha amino acid metabolic process GO:1901605 59 0.016
exocrine pancreas development GO:0031017 7 0.016
peptidyl amino acid modification GO:0018193 336 0.016
histone lysine methylation GO:0034968 50 0.016
negative regulation of phosphate metabolic process GO:0045936 184 0.016
asymmetric neuroblast division GO:0055059 1 0.016
negative regulation of cell size GO:0045792 3 0.016
negative regulation of molecular function GO:0044092 258 0.016
leukocyte proliferation GO:0070661 172 0.016
peptide secretion GO:0002790 114 0.016
mitotic recombination GO:0006312 3 0.016
coenzyme metabolic process GO:0006732 52 0.015
somatic recombination of immunoglobulin gene segments GO:0016447 42 0.015
regulation of intracellular protein transport GO:0033157 82 0.015
response to extracellular stimulus GO:0009991 127 0.015
anion transport GO:0006820 177 0.015
organonitrogen compound biosynthetic process GO:1901566 192 0.015
dna packaging GO:0006323 30 0.015
proteasomal protein catabolic process GO:0010498 98 0.015
cellular lipid metabolic process GO:0044255 323 0.015
nucleotide excision repair GO:0006289 13 0.015
cellular modified amino acid metabolic process GO:0006575 63 0.015
male meiosis GO:0007140 37 0.015
small molecule biosynthetic process GO:0044283 132 0.015
t cell activation GO:0042110 289 0.015
gtp metabolic process GO:0046039 144 0.015
ectodermal digestive tract development GO:0007439 1 0.015
organophosphate biosynthetic process GO:0090407 122 0.015
skeletal system development GO:0001501 356 0.015
purine nucleoside monophosphate metabolic process GO:0009126 81 0.015
chromosome condensation GO:0030261 10 0.015
regulation of endopeptidase activity GO:0052548 89 0.015
cation transport GO:0006812 399 0.014
resolution of meiotic recombination intermediates GO:0000712 4 0.014
release of cytochrome c from mitochondria GO:0001836 23 0.014
genitalia development GO:0048806 37 0.014
regulation of proteolysis GO:0030162 164 0.014
protein alkylation GO:0008213 81 0.014
negative regulation of cell development GO:0010721 169 0.014
connective tissue development GO:0061448 179 0.014
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.014
positive regulation of proteolysis GO:0045862 85 0.014
blastocyst development GO:0001824 80 0.014
blastocyst growth GO:0001832 23 0.014
production of molecular mediator of immune response GO:0002440 103 0.014
regulation of histone modification GO:0031056 56 0.014
nucleocytoplasmic transport GO:0006913 139 0.014
carbohydrate derivative biosynthetic process GO:1901137 183 0.014
protein catabolic process GO:0030163 221 0.014
response to oxidative stress GO:0006979 123 0.014
regulation of purine nucleotide catabolic process GO:0033121 122 0.014
positive regulation of programmed cell death GO:0043068 218 0.014
forebrain development GO:0030900 302 0.014
regulation of lymphocyte activation GO:0051249 240 0.014
regulation of apoptotic signaling pathway GO:2001233 197 0.014
negative regulation of chromosome organization GO:2001251 30 0.014
dna modification GO:0006304 50 0.014
endomembrane system organization GO:0010256 147 0.014
negative regulation of hydrolase activity GO:0051346 71 0.013
rhythmic process GO:0048511 174 0.013
deoxyribonucleotide metabolic process GO:0009262 14 0.013
positive regulation of mitotic cell cycle GO:0045931 41 0.013
regulation of chromatin modification GO:1903308 57 0.013
digestive tract development GO:0048565 190 0.013
positive regulation of chromosome organization GO:2001252 33 0.013
mitotic sister chromatid separation GO:0051306 9 0.013
regulation of cysteine type endopeptidase activity GO:2000116 65 0.013
regulation of dna replication GO:0006275 17 0.013
purine nucleotide catabolic process GO:0006195 211 0.013
chromatin assembly or disassembly GO:0006333 16 0.013
negative regulation of intracellular signal transduction GO:1902532 167 0.013
regulation of protein complex assembly GO:0043254 83 0.012
astral microtubule organization GO:0030953 3 0.012
positive regulation of hydrolase activity GO:0051345 148 0.012
protein targeting GO:0006605 143 0.012
peptide hormone secretion GO:0030072 109 0.012
synapsis GO:0007129 34 0.012
non recombinational repair GO:0000726 10 0.012
body morphogenesis GO:0010171 45 0.012
regulation of cell motility GO:2000145 236 0.012
female sex differentiation GO:0046660 84 0.012
cell maturation GO:0048469 127 0.012
negative regulation of phosphorylation GO:0042326 166 0.012
metaphase plate congression GO:0051310 2 0.012
negative regulation of purine nucleotide metabolic process GO:1900543 16 0.012
positive regulation of fibroblast proliferation GO:0048146 20 0.012
rna catabolic process GO:0006401 29 0.012
negative regulation of kinase activity GO:0033673 81 0.012
developmental maturation GO:0021700 193 0.012
regulation of atp metabolic process GO:1903578 17 0.012
positive regulation of immune effector process GO:0002699 107 0.012
circulatory system process GO:0003013 197 0.012
engulfment of apoptotic cell GO:0043652 3 0.011
positive regulation of intracellular transport GO:0032388 70 0.011
guanosine containing compound metabolic process GO:1901068 144 0.011
regulation of multi organism process GO:0043900 111 0.011
positive regulation of chromatin modification GO:1903310 28 0.011
regulation of interleukin 1 alpha production GO:0032650 4 0.011
rna interference GO:0016246 2 0.011
ras protein signal transduction GO:0007265 77 0.011
response to acid chemical GO:0001101 111 0.011
neural precursor cell proliferation GO:0061351 121 0.011
regulation of chromosome segregation GO:0051983 21 0.011
regulation of cell division GO:0051302 76 0.011
negative regulation of nucleotide catabolic process GO:0030812 9 0.011
regulation of hormone levels GO:0010817 211 0.011
leukocyte differentiation GO:0002521 342 0.011
protein import into nucleus GO:0006606 95 0.011
lymphocyte proliferation GO:0046651 164 0.011
regulation of cell migration GO:0030334 219 0.011
regulation of hormone secretion GO:0046883 88 0.011
homeostasis of number of cells GO:0048872 210 0.011
positive regulation of cell cycle phase transition GO:1901989 17 0.011
positive regulation of cell activation GO:0050867 158 0.011
rho protein signal transduction GO:0007266 32 0.011
regulation of cell activation GO:0050865 289 0.011
response to metal ion GO:0010038 47 0.011
dna replication checkpoint GO:0000076 2 0.011
learning or memory GO:0007611 148 0.011
cellular response to growth factor stimulus GO:0071363 197 0.011
regulation of protein serine threonine kinase activity GO:0071900 157 0.011
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.011
regulation of dna damage checkpoint GO:2000001 3 0.011
glial cell differentiation GO:0010001 131 0.011
striated muscle myosin thick filament assembly GO:0071688 1 0.011
spindle organization GO:0007051 28 0.011
negative regulation of protein maturation GO:1903318 79 0.010
cell activation involved in immune response GO:0002263 126 0.010
regulation of embryonic development GO:0045995 71 0.010
positive regulation of histone methylation GO:0031062 16 0.010
neural tube development GO:0021915 160 0.010
cell junction organization GO:0034330 77 0.010
regulation of response to wounding GO:1903034 189 0.010
response to oxygen levels GO:0070482 62 0.010
regulation of histone h3 k4 methylation GO:0051569 12 0.010
response to temperature stimulus GO:0009266 55 0.010
nuclear envelope organization GO:0006998 11 0.010
response to lipopolysaccharide GO:0032496 128 0.010

Lig1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.422
disease of cellular proliferation DOID:14566 0 0.422
organ system cancer DOID:0050686 0 0.183
gastrointestinal system cancer DOID:3119 0 0.164
large intestine cancer DOID:5672 0 0.067
intestinal cancer DOID:10155 0 0.067
disease of metabolism DOID:0014667 0 0.054
inherited metabolic disorder DOID:655 0 0.054
carbohydrate metabolic disorder DOID:2978 0 0.053
colorectal cancer DOID:9256 0 0.042
disease of anatomical entity DOID:7 0 0.035
nervous system disease DOID:863 0 0.035
neuropathy DOID:870 0 0.035
breast cancer DOID:1612 0 0.014
thoracic cancer DOID:5093 0 0.014