Mus musculus

253 known processes

Lrp5

low density lipoprotein receptor-related protein 5

(Aliases: HBM,LRP7,BMND1,KIAA4142,LR3,OPPG,mKIAA4142)

Lrp5 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
connective tissue development GO:0061448 179 0.783
Human Mouse
amine metabolic process GO:0009308 45 0.772
skeletal system development GO:0001501 356 0.758
epithelial cell proliferation GO:0050673 174 0.757
Mouse
formation of radial glial scaffolds GO:0021943 4 0.706
Mouse
regulation of hydrolase activity GO:0051336 246 0.704
Mouse
axis elongation involved in somitogenesis GO:0090245 4 0.698
Mouse
embryonic organ morphogenesis GO:0048562 276 0.688
Mouse
positive regulation of protein phosphorylation GO:0001934 242 0.642
Mouse
planar cell polarity pathway involved in cardiac muscle tissue morphogenesis GO:0061350 2 0.637
Mouse
skeletal system morphogenesis GO:0048705 203 0.629
Human Mouse
cell adhesion GO:0007155 329 0.592
mammary gland epithelium development GO:0061180 65 0.589
mammary placode formation GO:0060596 4 0.582
Mouse
peptidyl amino acid modification GO:0018193 336 0.577
Mouse
single organismal cell cell adhesion GO:0016337 131 0.576
gland development GO:0048732 330 0.547
cartilage development GO:0051216 140 0.544
Mouse
planar cell polarity pathway involved in pericardium morphogenesis GO:0061354 2 0.515
Mouse
regulation of cellular ketone metabolic process GO:0010565 66 0.503
negative regulation of protein metabolic process GO:0051248 282 0.495
Human
morphogenesis of a branching epithelium GO:0061138 193 0.480
cell proliferation involved in outflow tract morphogenesis GO:0061325 4 0.479
Mouse
positive regulation of protein ubiquitination involved in ubiquitin dependent protein catabolic process GO:2000060 8 0.477
Mouse
urogenital system development GO:0001655 261 0.471
Mouse
regulation of planar cell polarity pathway involved in outflow tract morphogenesis GO:2000163 1 0.465
Mouse
stem cell maintenance GO:0019827 130 0.464
regulation of protein kinase activity GO:0045859 232 0.458
Human Mouse
regionalization GO:0003002 337 0.456
blood vessel morphogenesis GO:0048514 285 0.454
cellular lipid metabolic process GO:0044255 323 0.448
ras protein signal transduction GO:0007265 77 0.444
single organism nuclear import GO:1902593 95 0.440
Mouse
positive regulation of programmed cell death GO:0043068 218 0.433
Mouse
lipid biosynthetic process GO:0008610 179 0.425
wnt signaling pathway involved in forebrain neuroblast division GO:0021874 2 0.422
Mouse
odontogenesis GO:0042476 78 0.421
Mouse
regulation of phospholipase a2 activity GO:0032429 3 0.415
Mouse
wnt signaling pathway involved in somitogenesis GO:0090244 4 0.403
Mouse
positive regulation of apoptotic process GO:0043065 217 0.401
Mouse
regulation of cardiac chamber morphogenesis GO:1901219 2 0.400
Mouse
regulation of protein serine threonine kinase activity GO:0071900 157 0.400
Human Mouse
regulation of cell migration GO:0030334 219 0.392
Mouse
positive regulation of protein modification process GO:0031401 299 0.380
Mouse
regulation of cellular amine metabolic process GO:0033238 20 0.377
positive regulation of map kinase activity GO:0043406 84 0.370
Mouse
sensory perception GO:0007600 245 0.367
rho protein signal transduction GO:0007266 32 0.362
appendage morphogenesis GO:0035107 149 0.362
regulation of cellular catabolic process GO:0031329 242 0.362
Mouse
limb development GO:0060173 166 0.359
cellular macromolecule catabolic process GO:0044265 206 0.352
Mouse
positive regulation of cellular catabolic process GO:0031331 148 0.348
Mouse
kidney development GO:0001822 213 0.345
Mouse
striated muscle tissue development GO:0014706 293 0.344
Mouse
morphogenesis of a branching structure GO:0001763 203 0.331
regulation of cartilage development GO:0061035 44 0.331
negative regulation of cardiac chamber morphogenesis GO:1901220 2 0.330
Mouse
canonical wnt signaling pathway involved in heart development GO:0061316 3 0.329
Mouse
synapse organization GO:0050808 125 0.329
Mouse
cellular amino acid metabolic process GO:0006520 103 0.328
fat cell differentiation GO:0045444 160 0.324
Human Mouse
digestive tract development GO:0048565 190 0.324
regulation of map kinase activity GO:0043405 120 0.323
Mouse
cardiac septum development GO:0003279 59 0.321
Mouse
neuron projection guidance GO:0097485 141 0.317
sensory perception of sound GO:0007605 97 0.313
cellular amine metabolic process GO:0044106 44 0.312
branching involved in mammary gland duct morphogenesis GO:0060444 27 0.311
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.302
Mouse
gtp metabolic process GO:0046039 144 0.293
canonical wnt signaling pathway involved in regulation of cell proliferation GO:0044340 3 0.293
Mouse
actin cytoskeleton organization GO:0030036 220 0.291
Mouse
positive regulation of protein kinase activity GO:0045860 144 0.289
Mouse
odontogenesis of dentin containing tooth GO:0042475 66 0.284
Mouse
negative regulation of planar cell polarity pathway involved in pericardium morphogenesis GO:2000166 1 0.280
Mouse
regulation of transferase activity GO:0051338 263 0.280
Human Mouse
positive regulation of mapk cascade GO:0043410 170 0.277
Mouse
germ cell development GO:0007281 185 0.276
planar cell polarity pathway involved in cardiac right atrium morphogenesis GO:0061349 2 0.273
Mouse
muscle cell differentiation GO:0042692 261 0.272
bone morphogenesis GO:0060349 78 0.266
Human Mouse
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 61 0.263
regulation of cellular amino acid metabolic process GO:0006521 5 0.263
negative regulation of fat cell differentiation GO:0045599 36 0.262
Mouse
guanosine containing compound metabolic process GO:1901068 144 0.259
membrane organization GO:0061024 245 0.258
Mouse
establishment of protein localization to organelle GO:0072594 118 0.256
Mouse Fly
embryonic placenta development GO:0001892 98 0.255
locomotory behavior GO:0007626 195 0.254
regulation of epithelial to mesenchymal transition GO:0010717 22 0.252
regulation of mapk cascade GO:0043408 248 0.250
Mouse
regulation of planar cell polarity pathway involved in ventricular septum morphogenesis GO:2000148 1 0.249
Mouse
hormone secretion GO:0046879 128 0.248
peptidyl serine modification GO:0018209 83 0.246
planar cell polarity pathway involved in outflow tract morphogenesis GO:0061347 2 0.245
Mouse
positive regulation of transferase activity GO:0051347 167 0.245
Mouse
regulation of homeostatic process GO:0032844 182 0.243
positive regulation of cell death GO:0010942 224 0.242
Mouse
protein localization to membrane GO:0072657 108 0.241
Mouse
wound healing GO:0042060 157 0.240
nuclear transport GO:0051169 139 0.239
Mouse
myeloid cell differentiation GO:0030099 233 0.239
positive regulation of kinase activity GO:0033674 155 0.234
Mouse
regulation of rho gtpase activity GO:0032319 58 0.232
nuclear import GO:0051170 95 0.232
Mouse
canonical wnt signaling pathway involved in neural plate anterior posterior pattern formation GO:0060823 1 0.232
planar cell polarity pathway involved in ventricular septum morphogenesis GO:0061348 2 0.232
Mouse
metal ion homeostasis GO:0055065 189 0.231
regulation of cardioblast differentiation GO:0051890 3 0.226
limb morphogenesis GO:0035108 149 0.224
enamel mineralization GO:0070166 7 0.224
regulation of organelle organization GO:0033043 289 0.221
Human Mouse
cellular protein catabolic process GO:0044257 155 0.220
Mouse
muscle tissue development GO:0060537 308 0.220
Mouse
jnk cascade GO:0007254 72 0.216
mapk cascade GO:0000165 281 0.215
Mouse
regulation of protein import into nucleus GO:0042306 52 0.214
regulation of actin cytoskeleton organization GO:0032956 84 0.213
Mouse
regulation of cell motility GO:2000145 236 0.213
Mouse
wnt signaling pathway GO:0016055 188 0.212
regulation of membrane potential GO:0042391 192 0.211
mesoderm morphogenesis GO:0048332 64 0.211
positive regulation of jnk cascade GO:0046330 46 0.208
neuron death GO:0070997 154 0.206
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.206
Mouse
bone development GO:0060348 120 0.206
fertilization GO:0009566 127 0.204
regulation of nucleocytoplasmic transport GO:0046822 73 0.200
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.200
Mouse
stem cell differentiation GO:0048863 268 0.198
forebrain generation of neurons GO:0021872 63 0.198
Mouse
negative regulation of cellular protein metabolic process GO:0032269 247 0.198
Human
negative regulation of cellular amine metabolic process GO:0033239 1 0.197
sensory organ morphogenesis GO:0090596 242 0.195
Human Mouse Fly
mesenchyme development GO:0060485 152 0.195
Mouse
regulation of rho protein signal transduction GO:0035023 71 0.194
regulation of cell cycle process GO:0010564 160 0.194
Human
nitrogen compound transport GO:0071705 271 0.194
regulation of nucleotide metabolic process GO:0006140 169 0.193
mammary gland morphogenesis GO:0060443 54 0.191
immune effector process GO:0002252 321 0.191
stress activated mapk cascade GO:0051403 80 0.190
guanosine containing compound catabolic process GO:1901069 144 0.189
muscle cell development GO:0055001 133 0.189
stress activated protein kinase signaling cascade GO:0031098 81 0.188
glycerolipid metabolic process GO:0046486 122 0.188
synapse assembly GO:0007416 56 0.188
Mouse
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.186
macromolecule catabolic process GO:0009057 281 0.184
Mouse
protein targeting GO:0006605 143 0.184
Mouse Fly
lipid transport GO:0006869 98 0.181
Mouse
leukocyte differentiation GO:0002521 342 0.180
positive regulation of stress activated mapk cascade GO:0032874 48 0.178
regulation of ras protein signal transduction GO:0046578 114 0.177
microtubule based process GO:0007017 236 0.177
cognition GO:0050890 149 0.176
Fly
adult behavior GO:0030534 135 0.176
regulation of actin filament based process GO:0032970 99 0.175
Mouse
regulation of cellular component biogenesis GO:0044087 181 0.174
tooth mineralization GO:0034505 9 0.174
negative regulation of neuron projection development GO:0010977 50 0.173
Mouse
cardiac right atrium morphogenesis GO:0003213 3 0.171
Mouse
small gtpase mediated signal transduction GO:0007264 97 0.170
organic hydroxy compound metabolic process GO:1901615 203 0.170
apoptotic signaling pathway GO:0097190 306 0.170
regulation of kinase activity GO:0043549 249 0.169
Human Mouse
ephrin receptor signaling pathway GO:0048013 20 0.169
positive regulation of jun kinase activity GO:0043507 30 0.169
camera type eye development GO:0043010 266 0.168
protein import into nucleus GO:0006606 95 0.167
Mouse
negative regulation of cellular component organization GO:0051129 194 0.166
Mouse
regulation of muscle tissue development GO:1901861 97 0.166
Mouse
ossification GO:0001503 216 0.166
ameboidal type cell migration GO:0001667 128 0.165
nucleocytoplasmic transport GO:0006913 139 0.165
Mouse
cardiac muscle tissue morphogenesis GO:0055008 44 0.164
Mouse
positive regulation of rho gtpase activity GO:0032321 41 0.163
embryonic skeletal system development GO:0048706 120 0.163
epithelial tube morphogenesis GO:0060562 303 0.162
regulation of smad protein import into nucleus GO:0060390 3 0.162
central nervous system neuron differentiation GO:0021953 162 0.158
forebrain development GO:0030900 302 0.158
Mouse
positive regulation of secondary heart field cardioblast proliferation GO:0072513 4 0.158
metencephalon development GO:0022037 89 0.157
Mouse
purine ribonucleoside metabolic process GO:0046128 241 0.156
transmembrane transport GO:0055085 412 0.156
intracellular cholesterol transport GO:0032367 3 0.155
Mouse
cardiac ventricle development GO:0003231 83 0.155
Mouse
embryonic limb morphogenesis GO:0030326 126 0.155
regulation of binding GO:0051098 111 0.154
Mouse
mammary gland duct morphogenesis GO:0060603 38 0.153
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.152
Mouse
purine nucleoside metabolic process GO:0042278 241 0.150
regulation of epithelial cell proliferation GO:0050678 141 0.150
Mouse
lung induction GO:0060492 3 0.149
single organism cell adhesion GO:0098602 156 0.149
regulation of chondrocyte differentiation GO:0032330 33 0.147
sensory perception of mechanical stimulus GO:0050954 107 0.146
negative regulation of protein phosphorylation GO:0001933 126 0.146
Human
negative regulation of protein modification process GO:0031400 163 0.144
Human
regulation of establishment of protein localization GO:0070201 181 0.144
regulation of body fluid levels GO:0050878 162 0.144
protein localization to organelle GO:0033365 185 0.144
Mouse Fly
chondrocyte differentiation GO:0002062 72 0.144
heart field specification GO:0003128 6 0.142
embryonic digit morphogenesis GO:0042733 56 0.141
gtp catabolic process GO:0006184 143 0.141
embryonic skeletal system morphogenesis GO:0048704 91 0.141
protein modification by small protein conjugation GO:0032446 187 0.141
Mouse
axial mesoderm formation GO:0048320 3 0.140
axonogenesis GO:0007409 274 0.139
Mouse
positive regulation of cell adhesion GO:0045785 80 0.139
regulation of intracellular protein transport GO:0033157 82 0.138
dendritic spine organization GO:0097061 26 0.137
cartilage development involved in endochondral bone morphogenesis GO:0060351 24 0.137
cell substrate adhesion GO:0031589 130 0.135
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.135
regulation of protein localization GO:0032880 231 0.135
vagus nerve development GO:0021564 3 0.135
epithelial to mesenchymal transition GO:0001837 47 0.134
myeloid cell homeostasis GO:0002262 114 0.133
negative regulation of planar cell polarity pathway involved in heart morphogenesis GO:2000160 1 0.133
Mouse
hepaticobiliary system development GO:0061008 67 0.132
establishment of planar polarity GO:0001736 28 0.131
mesodermal cell migration GO:0008078 4 0.131
regulation of apoptotic signaling pathway GO:2001233 197 0.131
cellular protein complex assembly GO:0043623 116 0.130
palate development GO:0060021 76 0.129
Mouse
anatomical structure homeostasis GO:0060249 145 0.129
Mouse
regulation of fat cell differentiation GO:0045598 81 0.128
Human Mouse
purine nucleotide metabolic process GO:0006163 302 0.128
negative regulation of wnt signaling pathway involved in heart development GO:0003308 4 0.127
Mouse
regulation of purine nucleotide catabolic process GO:0033121 122 0.127
pallium development GO:0021543 120 0.127
Mouse
regulation of cell adhesion GO:0030155 154 0.125
positive regulation of cell proliferation involved in heart valve morphogenesis GO:0003251 1 0.125
regulation of secretion by cell GO:1903530 249 0.125
nucleoside phosphate metabolic process GO:0006753 338 0.124
cardiocyte differentiation GO:0035051 87 0.124
Mouse
polarity specification of proximal distal axis GO:0010085 2 0.124
post anal tail morphogenesis GO:0036342 23 0.124
Mouse
cellular nitrogen compound catabolic process GO:0044270 280 0.122
salivary gland morphogenesis GO:0007435 33 0.122
negative regulation of cell migration GO:0030336 59 0.122
Mouse
regulation of jnk cascade GO:0046328 62 0.122
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.121
labyrinthine layer blood vessel development GO:0060716 21 0.121
jak stat cascade GO:0007259 42 0.121
Mouse
axial mesoderm development GO:0048318 8 0.121
negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis GO:2000151 1 0.120
Mouse
regulation of cell cycle GO:0051726 281 0.120
Human
negative regulation of cell projection organization GO:0031345 56 0.119
Mouse
cell cell junction organization GO:0045216 72 0.118
neural tube closure GO:0001843 90 0.118
Mouse
cellular homeostasis GO:0019725 240 0.118
branching morphogenesis of an epithelial tube GO:0048754 159 0.118
regulation of neuron apoptotic process GO:0043523 122 0.118
protein localization to nucleus GO:0034504 121 0.118
Mouse
ribose phosphate metabolic process GO:0019693 291 0.118
developmental maturation GO:0021700 193 0.117
nucleotide metabolic process GO:0009117 332 0.117
protein import GO:0017038 101 0.117
Mouse
bmp signaling pathway GO:0030509 93 0.117
positive regulation of organelle organization GO:0010638 128 0.116
Human
determination of heart left right asymmetry GO:0061371 48 0.114
Mouse
cell junction organization GO:0034330 77 0.114
planar cell polarity pathway involved in heart morphogenesis GO:0061346 3 0.114
Mouse
digestive system development GO:0055123 200 0.114
negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis GO:2000164 1 0.114
Mouse
cation transport GO:0006812 399 0.113
acylglycerol metabolic process GO:0006639 55 0.113
fat soluble vitamin biosynthetic process GO:0042362 4 0.112
adherens junction assembly GO:0034333 22 0.112
intracellular sterol transport GO:0032366 3 0.112
Mouse
establishment of planar polarity involved in neural tube closure GO:0090177 15 0.111
regulation of protein localization to nucleus GO:1900180 60 0.111
heterocycle catabolic process GO:0046700 280 0.111
t cell activation GO:0042110 289 0.111
respiratory system development GO:0060541 190 0.110
Mouse
respiratory tube development GO:0030323 167 0.110
regulation of jun kinase activity GO:0043506 40 0.109
regulation of canonical wnt signaling pathway GO:0060828 82 0.109
Human
nucleobase containing small molecule metabolic process GO:0055086 352 0.109
nephron epithelium morphogenesis GO:0072088 68 0.109
endochondral bone morphogenesis GO:0060350 50 0.108
erythrocyte differentiation GO:0030218 88 0.108
trachea cartilage morphogenesis GO:0060535 4 0.108
Mouse
regulation of lymphocyte proliferation GO:0050670 117 0.108
regulation of planar cell polarity pathway involved in neural tube closure GO:2000167 1 0.107
Mouse
negative regulation of growth GO:0045926 99 0.107
cardiac chamber development GO:0003205 108 0.106
Mouse
regulation of stem cell proliferation GO:0072091 78 0.106
Human Mouse
muscle contraction GO:0006936 101 0.106
cell type specific apoptotic process GO:0097285 268 0.106
angiogenesis GO:0001525 201 0.106
inorganic ion transmembrane transport GO:0098660 234 0.106
regulation of cellular protein catabolic process GO:1903362 61 0.104
Mouse
peptide secretion GO:0002790 114 0.104
protein catabolic process GO:0030163 221 0.104
Mouse
embryonic appendage morphogenesis GO:0035113 126 0.103
aromatic compound catabolic process GO:0019439 286 0.102
actomyosin structure organization GO:0031032 56 0.101
regulation of intracellular transport GO:0032386 159 0.101
regulation of stem cell differentiation GO:2000736 50 0.101
cell junction assembly GO:0034329 52 0.101
heart morphogenesis GO:0003007 178 0.100
Mouse
neuronal action potential GO:0019228 54 0.100
leukocyte migration GO:0050900 124 0.100
positive regulation of ras gtpase activity GO:0032320 65 0.099
small molecule biosynthetic process GO:0044283 132 0.099
glial cell differentiation GO:0010001 131 0.099
Mouse
head morphogenesis GO:0060323 34 0.098
Mouse
chemotaxis GO:0006935 247 0.098
dephosphorylation GO:0016311 129 0.098
cell cell adhesion GO:0098609 41 0.097
central nervous system vasculogenesis GO:0022009 3 0.097
multicellular organismal homeostasis GO:0048871 164 0.096
Mouse
nucleoside catabolic process GO:0009164 206 0.096
regulation of transforming growth factor beta receptor signaling pathway GO:0017015 43 0.096
spermatid differentiation GO:0048515 115 0.096
metanephric loop of henle development GO:0072236 4 0.096
response to transforming growth factor beta GO:0071559 88 0.096
organelle fission GO:0048285 170 0.095
Human
axon guidance GO:0007411 141 0.095
protein ubiquitination involved in ubiquitin dependent protein catabolic process GO:0042787 25 0.095
Mouse
regulation of organ morphogenesis GO:2000027 144 0.095
Mouse
myotube differentiation GO:0014902 105 0.095
ribonucleotide catabolic process GO:0009261 208 0.094
stem cell development GO:0048864 219 0.094
morphogenesis of a polarized epithelium GO:0001738 37 0.094
regulation of skeletal muscle fiber differentiation GO:1902809 3 0.093
intracellular protein transport GO:0006886 204 0.093
Mouse Fly
regulation of ras gtpase activity GO:0032318 88 0.093
skin development GO:0043588 220 0.093
Mouse
regulation of proteolysis GO:0030162 164 0.093
Mouse
organonitrogen compound catabolic process GO:1901565 264 0.093
cellular response to glucose stimulus GO:0071333 45 0.092
tissue remodeling GO:0048771 102 0.092
nucleoside triphosphate metabolic process GO:0009141 230 0.092
negative regulation of neuron differentiation GO:0045665 101 0.092
Mouse
regulation of secretion GO:0051046 274 0.091
negative regulation of phosphate metabolic process GO:0045936 184 0.091
Human
positive regulation of transcription from rna polymerase ii promoter involved in heart development GO:1901228 4 0.091
bundle of his development GO:0003166 4 0.091
ribonucleotide metabolic process GO:0009259 291 0.091
cellular ketone metabolic process GO:0042180 84 0.091
multicellular organismal signaling GO:0035637 91 0.091
positive regulation of transcription from rna polymerase ii promoter involved in myocardial precursor cell differentiation GO:0003257 3 0.091
cytoplasmic transport GO:0016482 234 0.090
Mouse Fly
digestive tract morphogenesis GO:0048546 147 0.090
negative regulation of canonical wnt signaling pathway involved in neural plate anterior posterior pattern formation GO:0060829 1 0.090
ribonucleoside triphosphate metabolic process GO:0009199 220 0.089
action potential GO:0001508 78 0.089
amide transport GO:0042886 138 0.089
positive regulation of transcription from rna polymerase ii promoter involved in cellular response to chemical stimulus GO:1901522 7 0.088
skeletal muscle fiber development GO:0048741 58 0.088
cellular response to monosaccharide stimulus GO:0071326 47 0.088
homeostasis of number of cells GO:0048872 210 0.088
organic cyclic compound catabolic process GO:1901361 295 0.088
regulation of microtubule based process GO:0032886 52 0.088
steroid metabolic process GO:0008202 119 0.087
cardiac endothelial cell differentiation GO:0003348 4 0.087
regulation of stress activated mapk cascade GO:0032872 69 0.087
regulation of insulin secretion involved in cellular response to glucose stimulus GO:0061178 31 0.087
circulatory system process GO:0003013 197 0.087
Human
regulation of system process GO:0044057 200 0.087
neuroblast differentiation GO:0014016 2 0.087
cytokine production GO:0001816 319 0.086
modification dependent macromolecule catabolic process GO:0043632 133 0.086
Mouse
positive regulation of transcription from rna polymerase ii promoter involved in smooth muscle cell differentiation GO:2000721 2 0.086
negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis GO:2000162 1 0.086
Mouse
morphogenesis of an epithelial sheet GO:0002011 27 0.086
Mouse
regulation of circadian rhythm GO:0042752 58 0.085
positive regulation of cell motility GO:2000147 116 0.085
endomembrane system organization GO:0010256 147 0.084
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.084
gastrulation GO:0007369 116 0.084
positive regulation of epithelial cell proliferation involved in lung morphogenesis GO:0060501 3 0.084
fibroblast growth factor receptor signaling pathway GO:0008543 46 0.083
cellular response to growth factor stimulus GO:0071363 197 0.083
specification of organ identity GO:0010092 30 0.082
muscle system process GO:0003012 141 0.082
regulation of mitotic cell cycle GO:0007346 126 0.082
Human
regulation of bmp signaling pathway GO:0030510 60 0.082
cardiac chamber morphogenesis GO:0003206 93 0.082
Mouse
regulation of protein targeting GO:1903533 61 0.082
regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis GO:2000161 1 0.081
Mouse
renal system development GO:0072001 225 0.081
Mouse
neural precursor cell proliferation GO:0061351 121 0.081
Mouse
positive regulation of hydrolase activity GO:0051345 148 0.081
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.081
protein autophosphorylation GO:0046777 61 0.081
mesenchymal cell proliferation involved in ureter development GO:0072198 4 0.081
notochord formation GO:0014028 5 0.081
sterol metabolic process GO:0016125 58 0.081
negative regulation of synapse assembly GO:0051964 3 0.081
meiotic cell cycle process GO:1903046 77 0.080
positive regulation of gtpase activity GO:0043547 85 0.080
positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 12 0.080
cell maturation GO:0048469 127 0.080
synaptic transmission GO:0007268 329 0.080
kidney morphogenesis GO:0060993 83 0.079
retina morphogenesis in camera type eye GO:0060042 45 0.079
Human Mouse
amelogenesis GO:0097186 12 0.079
spermatid development GO:0007286 108 0.078
regulation of reproductive process GO:2000241 66 0.078
dna metabolic process GO:0006259 303 0.077
axial mesoderm morphogenesis GO:0048319 5 0.077
negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis GO:2000149 1 0.077
Mouse
lipid localization GO:0010876 126 0.076
Mouse
negative regulation of osteoblast proliferation GO:0033689 4 0.076
regulation of neural precursor cell proliferation GO:2000177 70 0.076
Mouse
somitogenesis GO:0001756 69 0.076
Mouse
purine ribonucleotide catabolic process GO:0009154 208 0.076
cardiac muscle tissue development GO:0048738 130 0.076
Mouse
inflammatory response GO:0006954 244 0.076
negative regulation of cell proliferation GO:0008285 296 0.076
Mouse
glycosyl compound catabolic process GO:1901658 206 0.075
positive regulation of protein ubiquitination GO:0031398 27 0.075
Mouse
regulation of actin filament bundle assembly GO:0032231 18 0.075
regulation of protein modification by small protein conjugation or removal GO:1903320 57 0.075
Mouse
positive regulation of binding GO:0051099 49 0.074
Mouse
canonical wnt signaling pathway involved in cardiac neural crest cell differentiation involved in heart development GO:0061310 1 0.074
Mouse
endocrine system development GO:0035270 98 0.074
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.074
positive regulation of protein modification by small protein conjugation or removal GO:1903322 30 0.074
Mouse
cell matrix adhesion GO:0007160 68 0.074
mesenchymal cell differentiation GO:0048762 107 0.074
Mouse
nucleoside triphosphate catabolic process GO:0009143 205 0.074
ribonucleoside catabolic process GO:0042454 206 0.074
compound eye development GO:0048749 1 0.073
Fly
smooth muscle cell migration GO:0014909 10 0.073
Mouse
regulation of transmembrane transport GO:0034762 128 0.073
striated muscle contraction GO:0006941 45 0.072
negative regulation of molecular function GO:0044092 258 0.072
Human
lung development GO:0030324 164 0.072
nephron development GO:0072006 109 0.072
renal inner medulla development GO:0072053 3 0.072
skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration GO:0014834 3 0.072
lymphocyte proliferation GO:0046651 164 0.072
regulation of ion transport GO:0043269 215 0.072
hindbrain radial glia guided cell migration GO:0021932 12 0.072
Mouse
regulation of t cell proliferation GO:0042129 92 0.072
regulation of lipid metabolic process GO:0019216 118 0.071
nucleoside metabolic process GO:0009116 246 0.071
meiotic cell cycle GO:0051321 122 0.071
negative regulation of wnt signaling pathway GO:0030178 73 0.071
Mouse
cation homeostasis GO:0055080 212 0.071
axon ensheathment GO:0008366 76 0.071
epithelial cell morphogenesis GO:0003382 41 0.071
regulation of cell cell adhesion mediated by cadherin GO:2000047 2 0.071
regulation of myeloid cell differentiation GO:0045637 96 0.071
positive regulation of apoptotic signaling pathway GO:2001235 95 0.070
body morphogenesis GO:0010171 45 0.070
Mouse
centromeric sister chromatid cohesion GO:0070601 3 0.070
oxidation reduction process GO:0055114 342 0.070
positive regulation of cellular amine metabolic process GO:0033240 5 0.070
adult locomotory behavior GO:0008344 91 0.070
atrioventricular bundle cell differentiation GO:0003167 1 0.070
placenta development GO:0001890 140 0.070
morphogenesis of embryonic epithelium GO:0016331 159 0.069
Mouse
gliogenesis GO:0042063 141 0.069
Mouse
regulation of protein binding GO:0043393 60 0.069
positive regulation of actin filament bundle assembly GO:0032233 11 0.069
hindbrain morphogenesis GO:0021575 46 0.069
Mouse
regulation of cytoskeleton organization GO:0051493 122 0.069
Mouse
ribonucleoside metabolic process GO:0009119 245 0.069
male gamete generation GO:0048232 285 0.069
insulin secretion involved in cellular response to glucose stimulus GO:0035773 36 0.069
regulation of protein transport GO:0051223 163 0.069
canonical wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation GO:0061324 2 0.069
Mouse
non canonical wnt signaling pathway via jnk cascade GO:0038031 3 0.069
myeloid leukocyte differentiation GO:0002573 119 0.068
regulation of cell division GO:0051302 76 0.068
Human
forebrain neuron differentiation GO:0021879 52 0.068
mesenchymal cell development GO:0014031 93 0.068
positive regulation of tissue remodeling GO:0034105 19 0.068
Mouse
forebrain regionalization GO:0021871 25 0.067
retina vasculature morphogenesis in camera type eye GO:0061299 10 0.067
pericardium development GO:0060039 16 0.067
Mouse
endodermal cell fate specification GO:0001714 4 0.067
multi multicellular organism process GO:0044706 109 0.067
purine containing compound metabolic process GO:0072521 311 0.067
b cell activation GO:0042113 161 0.067
negative regulation of wound healing GO:0061045 14 0.067
neuron apoptotic process GO:0051402 142 0.067
regulation of nucleoside metabolic process GO:0009118 130 0.066
embryonic heart tube development GO:0035050 65 0.066
Mouse
ectodermal placode formation GO:0060788 16 0.066
Mouse
purine containing compound catabolic process GO:0072523 213 0.066
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 56 0.066
Mouse
epidermis development GO:0008544 187 0.066
Mouse
single fertilization GO:0007338 82 0.066
negative regulation of bmp signaling pathway GO:0030514 35 0.066
regulation of neuron death GO:1901214 134 0.065
mesoderm development GO:0007498 100 0.065

Lrp5 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.117
Human
cardiovascular system disease DOID:1287 0 0.117