|
|
activation of nf kappab inducing kinase activity
|
GO:0007250 |
4 |
1.000
|
Human |
|
|
i kappab kinase nf kappab signaling
|
GO:0007249 |
85 |
0.999
|
|
|
|
nik nf kappab signaling
|
GO:0038061 |
14 |
0.996
|
Human |
|
|
regulation of transferase activity
|
GO:0051338 |
263 |
0.996
|
|
|
|
regulation of defense response
|
GO:0031347 |
233 |
0.996
|
Fly |
|
|
regulation of kinase activity
|
GO:0043549 |
249 |
0.995
|
|
|
|
jnk cascade
|
GO:0007254 |
72 |
0.990
|
|
|
|
proteolysis involved in cellular protein catabolic process
|
GO:0051603 |
147 |
0.989
|
|
|
|
positive regulation of antimicrobial peptide production
|
GO:0002225 |
1 |
0.987
|
Fly |
|
|
regulation of protein kinase activity
|
GO:0045859 |
232 |
0.986
|
|
|
|
positive regulation of antibacterial peptide biosynthetic process
|
GO:0006963 |
1 |
0.984
|
Fly |
|
|
serine phosphorylation of stat protein
|
GO:0042501 |
3 |
0.982
|
|
|
|
regulation of jnk cascade
|
GO:0046328 |
62 |
0.976
|
|
|
|
positive regulation of kinase activity
|
GO:0033674 |
155 |
0.970
|
|
|
|
lymphocyte homeostasis
|
GO:0002260 |
64 |
0.970
|
|
|
|
regulation of stress activated mapk cascade
|
GO:0032872 |
69 |
0.966
|
|
|
|
positive regulation of protein phosphorylation
|
GO:0001934 |
242 |
0.965
|
|
|
|
positive regulation of protein kinase activity
|
GO:0045860 |
144 |
0.961
|
|
|
|
regulation of protein serine threonine kinase activity
|
GO:0071900 |
157 |
0.958
|
|
|
|
positive regulation of innate immune response
|
GO:0045089 |
80 |
0.944
|
|
|
|
digestive system development
|
GO:0055123 |
200 |
0.943
|
Worm |
|
|
endodermal cell fate specification
|
GO:0001714 |
4 |
0.941
|
Worm |
|
|
leukocyte homeostasis
|
GO:0001776 |
79 |
0.936
|
|
|
|
positive regulation of protein modification process
|
GO:0031401 |
299 |
0.935
|
|
|
|
b cell homeostasis
|
GO:0001782 |
34 |
0.935
|
|
|
|
cellular response to dna damage stimulus
|
GO:0006974 |
207 |
0.935
|
|
|
|
regulation of cellular response to stress
|
GO:0080135 |
159 |
0.933
|
|
|
|
negative regulation of necrotic cell death
|
GO:0060547 |
11 |
0.932
|
|
|
|
positive regulation of production of molecular mediator of immune response
|
GO:0002702 |
45 |
0.930
|
Human Fly |
|
|
activation of immune response
|
GO:0002253 |
138 |
0.929
|
|
|
|
digestive tract morphogenesis
|
GO:0048546 |
147 |
0.924
|
Worm |
|
|
cellular protein catabolic process
|
GO:0044257 |
155 |
0.921
|
|
|
|
leukocyte differentiation
|
GO:0002521 |
342 |
0.914
|
|
|
|
regulation of intrinsic apoptotic signaling pathway
|
GO:2001242 |
61 |
0.914
|
|
|
|
positive regulation of protein serine threonine kinase activity
|
GO:0071902 |
106 |
0.912
|
|
|
|
stress activated mapk cascade
|
GO:0051403 |
80 |
0.906
|
|
|
|
regulation of mapk cascade
|
GO:0043408 |
248 |
0.906
|
|
|
|
regulation of antibacterial peptide biosynthetic process
|
GO:0002808 |
1 |
0.902
|
Fly |
|
|
negative regulation of intracellular signal transduction
|
GO:1902532 |
167 |
0.897
|
|
|
|
antibacterial peptide production
|
GO:0002778 |
2 |
0.893
|
Fly |
|
|
cell cycle switching
|
GO:0060184 |
1 |
0.888
|
|
|
|
defense response to other organism
|
GO:0098542 |
197 |
0.881
|
Fly |
|
|
activation of innate immune response
|
GO:0002218 |
56 |
0.876
|
|
|
|
immune effector process
|
GO:0002252 |
321 |
0.874
|
Human Fly |
|
|
stress activated protein kinase signaling cascade
|
GO:0031098 |
81 |
0.870
|
|
|
|
regulation of nik nf kappab signaling
|
GO:1901222 |
10 |
0.866
|
Human |
|
|
dna metabolic process
|
GO:0006259 |
303 |
0.865
|
|
|
|
negative regulation of defense response
|
GO:0031348 |
77 |
0.864
|
|
|
|
transforming growth factor beta receptor signaling pathway
|
GO:0007179 |
71 |
0.851
|
|
|
|
protein modification by small protein conjugation
|
GO:0032446 |
187 |
0.851
|
|
|
|
homeostasis of number of cells
|
GO:0048872 |
210 |
0.849
|
|
|
|
peptidyl amino acid modification
|
GO:0018193 |
336 |
0.833
|
Human |
|
|
negative regulation of necroptotic process
|
GO:0060546 |
9 |
0.830
|
|
|
|
positive regulation of transferase activity
|
GO:0051347 |
167 |
0.830
|
|
|
|
immune response activating signal transduction
|
GO:0002757 |
116 |
0.829
|
|
|
|
positive regulation of sequence specific dna binding transcription factor activity
|
GO:0051091 |
68 |
0.821
|
|
|
|
cellular amine metabolic process
|
GO:0044106 |
44 |
0.815
|
|
|
|
cellular response to transforming growth factor beta stimulus
|
GO:0071560 |
88 |
0.815
|
|
|
|
interleukin 1 mediated signaling pathway
|
GO:0070498 |
4 |
0.811
|
|
|
|
regulation of protein import into nucleus
|
GO:0042306 |
52 |
0.806
|
|
|
|
antigen receptor mediated signaling pathway
|
GO:0050851 |
64 |
0.800
|
|
|
|
response to oxidative stress
|
GO:0006979 |
123 |
0.799
|
|
|
|
positive regulation of neuron death
|
GO:1901216 |
28 |
0.795
|
|
|
|
regulation of necrotic cell death
|
GO:0010939 |
13 |
0.794
|
|
|
|
intrinsic apoptotic signaling pathway
|
GO:0097193 |
132 |
0.784
|
|
|
|
mapk cascade
|
GO:0000165 |
281 |
0.782
|
|
|
|
t cell activation
|
GO:0042110 |
289 |
0.776
|
|
|
|
regulation of innate immune response
|
GO:0045088 |
91 |
0.766
|
|
|
|
positive regulation of nf kappab transcription factor activity
|
GO:0051092 |
30 |
0.761
|
|
|
|
positive regulation of stress activated mapk cascade
|
GO:0032874 |
48 |
0.750
|
|
|
|
germline cell cycle switching mitotic to meiotic cell cycle
|
GO:0051729 |
1 |
0.749
|
|
|
|
innate immune response
|
GO:0045087 |
157 |
0.745
|
|
|
|
peptidyl threonine phosphorylation
|
GO:0018107 |
31 |
0.743
|
|
|
|
positive regulation of nik nf kappab signaling
|
GO:1901224 |
7 |
0.743
|
Human |
|
|
cellular response to growth factor stimulus
|
GO:0071363 |
197 |
0.738
|
|
|
|
regulation of sequence specific dna binding transcription factor activity
|
GO:0051090 |
106 |
0.735
|
|
|
|
lymphocyte proliferation
|
GO:0046651 |
164 |
0.723
|
|
|
|
positive regulation of jnk cascade
|
GO:0046330 |
46 |
0.723
|
|
|
|
cytokine production
|
GO:0001816 |
319 |
0.722
|
Human |
|
|
embryonic epithelial tube formation
|
GO:0001838 |
130 |
0.722
|
|
|
|
myeloid cell differentiation
|
GO:0030099 |
233 |
0.721
|
|
|
|
striated muscle contraction
|
GO:0006941 |
45 |
0.720
|
|
|
|
nephrogenic mesenchyme morphogenesis
|
GO:0072134 |
2 |
0.706
|
|
|
|
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
|
GO:1902043 |
13 |
0.701
|
|
|
|
protein import into nucleus
|
GO:0006606 |
95 |
0.697
|
|
|
|
muscle system process
|
GO:0003012 |
141 |
0.695
|
|
|
|
protein polyubiquitination
|
GO:0000209 |
33 |
0.694
|
|
|
|
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
|
GO:0002460 |
145 |
0.692
|
Human |
|
|
immune response regulating signaling pathway
|
GO:0002764 |
125 |
0.690
|
|
|
|
protein modification by small protein conjugation or removal
|
GO:0070647 |
207 |
0.685
|
|
|
|
transmembrane transport
|
GO:0055085 |
412 |
0.683
|
|
|
|
epithelial cell proliferation
|
GO:0050673 |
174 |
0.679
|
|
|
|
regulation of jun kinase activity
|
GO:0043506 |
40 |
0.661
|
Human Fly |
|
|
positive regulation of map kinase activity
|
GO:0043406 |
84 |
0.651
|
|
|
|
epithelial tube formation
|
GO:0072175 |
130 |
0.649
|
|
|
|
positive regulation of protein localization to nucleus
|
GO:1900182 |
30 |
0.645
|
|
|
|
positive regulation of jun kinase activity
|
GO:0043507 |
30 |
0.642
|
Human Fly |
|
|
mammary gland lobule development
|
GO:0061377 |
22 |
0.637
|
|
|
|
positive regulation of cytokine biosynthetic process
|
GO:0042108 |
40 |
0.636
|
|
|
|
negative regulation of cell proliferation
|
GO:0008285 |
296 |
0.631
|
|
|
|
cell cycle switching mitotic to meiotic cell cycle
|
GO:0051728 |
1 |
0.626
|
|
|
|
negative regulation of b cell activation
|
GO:0050869 |
27 |
0.622
|
|
|
|
regulation of endoplasmic reticulum stress induced intrinsic apoptotic signaling pathway
|
GO:1902235 |
11 |
0.619
|
|
|
|
positive regulation of cytokine production
|
GO:0001819 |
174 |
0.608
|
Human |
|
|
epithelial tube morphogenesis
|
GO:0060562 |
303 |
0.607
|
|
|
|
amine metabolic process
|
GO:0009308 |
45 |
0.602
|
|
|
|
response to transforming growth factor beta
|
GO:0071559 |
88 |
0.601
|
|
|
|
programmed necrotic cell death
|
GO:0097300 |
28 |
0.600
|
|
|
|
cell fate commitment
|
GO:0045165 |
210 |
0.591
|
Worm |
|
|
peptidyl threonine modification
|
GO:0018210 |
31 |
0.590
|
|
|
|
regulation of transforming growth factor beta receptor signaling pathway
|
GO:0017015 |
43 |
0.585
|
|
|
|
positive regulation of cytoplasmic transport
|
GO:1903651 |
40 |
0.585
|
|
|
|
regulation of intracellular protein transport
|
GO:0033157 |
82 |
0.583
|
|
|
|
morphogenesis of embryonic epithelium
|
GO:0016331 |
159 |
0.582
|
|
|
|
response to endoplasmic reticulum stress
|
GO:0034976 |
53 |
0.574
|
|
|
|
regulation of cytokine production
|
GO:0001817 |
266 |
0.573
|
Human |
|
|
negative regulation of cellular amine metabolic process
|
GO:0033239 |
1 |
0.571
|
|
|
|
endoderm development
|
GO:0007492 |
45 |
0.567
|
Worm |
|
|
cellular macromolecule catabolic process
|
GO:0044265 |
206 |
0.562
|
|
|
|
negative regulation of lymphocyte proliferation
|
GO:0050672 |
45 |
0.561
|
|
|
|
regulation of organ morphogenesis
|
GO:2000027 |
144 |
0.556
|
|
|
|
positive regulation of cell proliferation involved in heart valve morphogenesis
|
GO:0003251 |
1 |
0.553
|
|
|
|
digestive tract development
|
GO:0048565 |
190 |
0.552
|
Worm |
|
|
cytokine production involved in immune response
|
GO:0002367 |
34 |
0.551
|
Human |
|
|
regulation of cellular amine metabolic process
|
GO:0033238 |
20 |
0.549
|
|
|
|
regulation of cytokine biosynthetic process
|
GO:0042035 |
59 |
0.549
|
|
|
|
negative regulation of immune system process
|
GO:0002683 |
209 |
0.548
|
|
|
|
peptidyl serine modification
|
GO:0018209 |
83 |
0.546
|
|
|
|
bmp signaling pathway
|
GO:0030509 |
93 |
0.542
|
|
|
|
trunk segmentation
|
GO:0035290 |
4 |
0.539
|
|
|
|
necrotic cell death
|
GO:0070265 |
30 |
0.538
|
|
|
|
protein ubiquitination
|
GO:0016567 |
171 |
0.537
|
|
|
|
negative regulation of protein modification process
|
GO:0031400 |
163 |
0.537
|
|
|
|
regulation of cytokine production involved in immune response
|
GO:0002718 |
26 |
0.535
|
Human |
|
|
respiratory system development
|
GO:0060541 |
190 |
0.532
|
|
|
|
response to growth factor
|
GO:0070848 |
198 |
0.531
|
|
|
|
cytokine biosynthetic process
|
GO:0042089 |
68 |
0.524
|
|
|
|
regulation of necroptotic process
|
GO:0060544 |
10 |
0.523
|
|
|
|
ripoptosome assembly involved in necroptotic process
|
GO:1901026 |
6 |
0.522
|
|
|
|
regulation of cellular amino acid metabolic process
|
GO:0006521 |
5 |
0.520
|
|
|
|
gastrulation
|
GO:0007369 |
116 |
0.516
|
Worm |
|
|
primary neural tube formation
|
GO:0014020 |
95 |
0.513
|
|
|
|
negative regulation of cellular protein metabolic process
|
GO:0032269 |
247 |
0.509
|
|
|
|
muscle contraction
|
GO:0006936 |
101 |
0.503
|
|
|
|
chromatin organization
|
GO:0006325 |
206 |
0.501
|
Human |
|
|
positive regulation of protein import into nucleus
|
GO:0042307 |
26 |
0.498
|
|
|
|
macromolecule catabolic process
|
GO:0009057 |
281 |
0.498
|
|
|
|
response to organonitrogen compound
|
GO:0010243 |
246 |
0.497
|
|
|
|
regulation of smad protein import into nucleus
|
GO:0060390 |
3 |
0.493
|
|
|
|
transmembrane receptor protein serine threonine kinase signaling pathway
|
GO:0007178 |
194 |
0.490
|
|
|
|
pattern recognition receptor signaling pathway
|
GO:0002221 |
47 |
0.490
|
|
|
|
cellular amino acid metabolic process
|
GO:0006520 |
103 |
0.489
|
|
|
|
endodermal cell fate commitment
|
GO:0001711 |
12 |
0.489
|
Worm |
|
|
positive regulation of apoptotic process
|
GO:0043065 |
217 |
0.484
|
|
|
|
apoptotic signaling pathway
|
GO:0097190 |
306 |
0.478
|
|
|
|
protein k63 linked ubiquitination
|
GO:0070534 |
6 |
0.473
|
|
|
|
skeletal system morphogenesis
|
GO:0048705 |
203 |
0.471
|
|
|
|
germ line stem cell division
|
GO:0042078 |
2 |
0.468
|
|
|
|
cardiocyte differentiation
|
GO:0035051 |
87 |
0.464
|
|
|
|
cellular response to oxidative stress
|
GO:0034599 |
76 |
0.463
|
|
|
|
interleukin 6 production
|
GO:0032635 |
58 |
0.455
|
|
|
|
gland development
|
GO:0048732 |
330 |
0.447
|
|
|
|
regulation of cellular ketone metabolic process
|
GO:0010565 |
66 |
0.441
|
|
|
|
immune response regulating cell surface receptor signaling pathway
|
GO:0002768 |
80 |
0.441
|
|
|
|
interferon beta biosynthetic process
|
GO:0045350 |
4 |
0.437
|
|
|
|
interferon beta production
|
GO:0032608 |
16 |
0.435
|
|
|
|
establishment of protein localization to organelle
|
GO:0072594 |
118 |
0.434
|
|
|
|
myeloid dendritic cell activation
|
GO:0001773 |
25 |
0.426
|
|
|
|
negative regulation of lymphocyte activation
|
GO:0051250 |
91 |
0.423
|
|
|
|
i kappab phosphorylation
|
GO:0007252 |
6 |
0.422
|
|
|
|
muscle tissue development
|
GO:0060537 |
308 |
0.420
|
|
|
|
bone development
|
GO:0060348 |
120 |
0.420
|
|
|
|
cell proliferation involved in heart valve development
|
GO:2000793 |
2 |
0.418
|
|
|
|
negative regulation of protein phosphorylation
|
GO:0001933 |
126 |
0.417
|
|
|
|
response to tumor necrosis factor
|
GO:0034612 |
26 |
0.413
|
|
|
|
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
|
GO:0002824 |
61 |
0.412
|
Human |
|
|
positive regulation of defense response
|
GO:0031349 |
124 |
0.406
|
Fly |
|
|
regulation of lymphocyte mediated immunity
|
GO:0002706 |
84 |
0.404
|
Human |
|
|
regulation of cell morphogenesis involved in differentiation
|
GO:0010769 |
151 |
0.404
|
|
|
|
protein catabolic process
|
GO:0030163 |
221 |
0.403
|
|
|
|
modification dependent macromolecule catabolic process
|
GO:0043632 |
133 |
0.400
|
|
|
|
mitotic cell cycle
|
GO:0000278 |
195 |
0.392
|
|
|
|
regulation of lymphocyte activation
|
GO:0051249 |
240 |
0.391
|
|
|
|
inflammatory response
|
GO:0006954 |
244 |
0.387
|
|
|
|
negative regulation of mapk cascade
|
GO:0043409 |
65 |
0.384
|
|
|
|
neural tube development
|
GO:0021915 |
160 |
0.384
|
|
|
|
ubiquitin dependent protein catabolic process
|
GO:0006511 |
129 |
0.384
|
|
|
|
positive regulation of neuron apoptotic process
|
GO:0043525 |
25 |
0.381
|
|
|
|
negative regulation of apoptotic signaling pathway
|
GO:2001234 |
104 |
0.378
|
|
|
|
negative regulation of intrinsic apoptotic signaling pathway
|
GO:2001243 |
34 |
0.368
|
|
|
|
cellular response to lipid
|
GO:0071396 |
145 |
0.367
|
Fly |
|
|
regulation of interleukin 6 production
|
GO:0032675 |
55 |
0.365
|
|
|
|
negative regulation of cellular amino acid metabolic process
|
GO:0045763 |
0 |
0.363
|
|
|
|
response to organic cyclic compound
|
GO:0014070 |
198 |
0.361
|
|
|
|
neural tube closure
|
GO:0001843 |
90 |
0.360
|
|
|
|
limb morphogenesis
|
GO:0035108 |
149 |
0.353
|
|
|
|
cellular response to abiotic stimulus
|
GO:0071214 |
56 |
0.353
|
|
|
|
regulation of cellular protein catabolic process
|
GO:1903362 |
61 |
0.352
|
|
|
|
regulation of ion transmembrane transporter activity
|
GO:0032412 |
54 |
0.352
|
|
|
|
regulation of bmp signaling pathway
|
GO:0030510 |
60 |
0.345
|
|
|
|
endocardial cell differentiation
|
GO:0060956 |
4 |
0.345
|
|
|
|
lipopolysaccharide mediated signaling pathway
|
GO:0031663 |
25 |
0.341
|
|
|
|
toll like receptor signaling pathway
|
GO:0002224 |
38 |
0.341
|
|
|
|
positive regulation of synaptic growth at neuromuscular junction
|
GO:0045887 |
1 |
0.338
|
|
|
|
urogenital system development
|
GO:0001655 |
261 |
0.336
|
|
|
|
regulation of mitotic cell cycle
|
GO:0007346 |
126 |
0.336
|
|
|
|
respiratory tube development
|
GO:0030323 |
167 |
0.336
|
|
|
|
response to oxygen levels
|
GO:0070482 |
62 |
0.334
|
|
|
|
hepaticobiliary system development
|
GO:0061008 |
67 |
0.329
|
|
|
|
positive regulation of lymphocyte mediated immunity
|
GO:0002708 |
62 |
0.325
|
Human |
|
|
nitrogen compound transport
|
GO:0071705 |
271 |
0.322
|
|
|
|
negative regulation of cell cycle
|
GO:0045786 |
123 |
0.319
|
|
|
|
neuron death
|
GO:0070997 |
154 |
0.319
|
|
|
|
regulation of cellular response to growth factor stimulus
|
GO:0090287 |
82 |
0.314
|
|
|
|
mitochondrion organization
|
GO:0007005 |
134 |
0.306
|
|
|
|
positive regulation of intracellular protein transport
|
GO:0090316 |
42 |
0.302
|
|
|
|
pathway restricted smad protein phosphorylation
|
GO:0060389 |
10 |
0.299
|
|
|
|
cellular response to tumor necrosis factor
|
GO:0071356 |
21 |
0.298
|
|
|
|
defense response to bacterium
|
GO:0042742 |
119 |
0.296
|
Fly |
|
|
regulation of interferon beta biosynthetic process
|
GO:0045357 |
4 |
0.293
|
|
|
|
nephrogenic mesenchyme development
|
GO:0072076 |
3 |
0.292
|
|
|
|
regulation of membrane potential
|
GO:0042391 |
192 |
0.291
|
|
|
|
odontogenesis
|
GO:0042476 |
78 |
0.291
|
|
|
|
positive regulation of myeloid leukocyte differentiation
|
GO:0002763 |
26 |
0.287
|
|
|
|
regulation of cell cycle
|
GO:0051726 |
281 |
0.287
|
|
|
|
neural tube formation
|
GO:0001841 |
108 |
0.287
|
|
|
|
rhythmic process
|
GO:0048511 |
174 |
0.287
|
|
|
|
skeletal system development
|
GO:0001501 |
356 |
0.287
|
|
|
|
cellular response to cytokine stimulus
|
GO:0071345 |
189 |
0.286
|
|
|
|
positive regulation of interleukin 2 production
|
GO:0032743 |
19 |
0.286
|
Human |
|
|
response to decreased oxygen levels
|
GO:0036293 |
59 |
0.285
|
|
|
|
convergent extension
|
GO:0060026 |
14 |
0.282
|
|
|
|
regulation of t cell activation
|
GO:0050863 |
170 |
0.278
|
|
|
|
positive regulation of transcription from rna polymerase ii promoter involved in cellular response to chemical stimulus
|
GO:1901522 |
7 |
0.275
|
|
|
|
production of molecular mediator of immune response
|
GO:0002440 |
103 |
0.273
|
Human Fly |
|
|
dendritic cell proliferation
|
GO:0044565 |
2 |
0.272
|
|
|
|
b cell proliferation
|
GO:0042100 |
53 |
0.269
|
|
|
|
regulation of adaptive immune response
|
GO:0002819 |
90 |
0.268
|
Human |
|
|
t cell receptor signaling pathway
|
GO:0050852 |
46 |
0.266
|
|
|
|
regulation of map kinase activity
|
GO:0043405 |
120 |
0.265
|
|
|
|
immune response activating cell surface receptor signaling pathway
|
GO:0002429 |
72 |
0.263
|
|
|
|
negative regulation of interleukin 5 production
|
GO:0032714 |
4 |
0.261
|
|
|
|
g1 s transition of mitotic cell cycle
|
GO:0000082 |
57 |
0.259
|
|
|
|
connective tissue development
|
GO:0061448 |
179 |
0.258
|
|
|
|
positive regulation of protein modification by small protein conjugation or removal
|
GO:1903322 |
30 |
0.258
|
|
|
|
regulation of cell activation
|
GO:0050865 |
289 |
0.257
|
|
|
|
positive regulation of immune effector process
|
GO:0002699 |
107 |
0.256
|
Human Fly |
|
|
response to uv
|
GO:0009411 |
44 |
0.255
|
|
|
|
tube closure
|
GO:0060606 |
91 |
0.254
|
|
|
|
peptidyl tyrosine phosphorylation
|
GO:0018108 |
143 |
0.252
|
|
|
|
regulation of defense response to virus
|
GO:0050688 |
18 |
0.249
|
|
|
|
heart growth
|
GO:0060419 |
45 |
0.248
|
|
|
|
regulation of protein modification by small protein conjugation or removal
|
GO:1903320 |
57 |
0.247
|
|
|
|
negative regulation of phosphorylation
|
GO:0042326 |
166 |
0.246
|
|
|
|
interleukin 6 biosynthetic process
|
GO:0042226 |
12 |
0.245
|
|
|
|
positive regulation of smad protein import into nucleus
|
GO:0060391 |
2 |
0.243
|
|
|
|
leukocyte proliferation
|
GO:0070661 |
172 |
0.243
|
|
|
|
regulation of protein targeting
|
GO:1903533 |
61 |
0.242
|
|
|
|
heart morphogenesis
|
GO:0003007 |
178 |
0.241
|
|
|
|
t cell proliferation
|
GO:0042098 |
120 |
0.241
|
|
|
|
regulation of establishment of protein localization
|
GO:0070201 |
181 |
0.240
|
|
|
|
regulation of defense response to bacterium
|
GO:1900424 |
3 |
0.240
|
Fly |
|
|
peptidyl serine phosphorylation
|
GO:0018105 |
74 |
0.236
|
|
|
|
brainstem development
|
GO:0003360 |
3 |
0.236
|
|
|
|
regulation of transporter activity
|
GO:0032409 |
57 |
0.235
|
|
|
|
type i interferon production
|
GO:0032606 |
29 |
0.231
|
|
|
|
epithelial to mesenchymal transition involved in endocardial cushion formation
|
GO:0003198 |
10 |
0.229
|
|
|
|
lung development
|
GO:0030324 |
164 |
0.228
|
|
|
|
positive regulation of mapk cascade
|
GO:0043410 |
170 |
0.227
|
|
|
|
response to inorganic substance
|
GO:0010035 |
96 |
0.226
|
|
|
|
positive regulation of defense response to bacterium
|
GO:1900426 |
1 |
0.226
|
Fly |
|
|
blood vessel morphogenesis
|
GO:0048514 |
285 |
0.224
|
|
|
|
regulation of neuron death
|
GO:1901214 |
134 |
0.223
|
|
|
|
axonogenesis
|
GO:0007409 |
274 |
0.222
|
|
|
|
myeloid leukocyte differentiation
|
GO:0002573 |
119 |
0.220
|
|
|
|
negative regulation of protein metabolic process
|
GO:0051248 |
282 |
0.219
|
|
|
|
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
|
GO:0002822 |
87 |
0.218
|
Human |
|
|
nuclear import
|
GO:0051170 |
95 |
0.217
|
|
|
|
cardiac muscle tissue development
|
GO:0048738 |
130 |
0.217
|
|
|
|
hair follicle development
|
GO:0001942 |
85 |
0.216
|
|
|
|
intrinsic apoptotic signaling pathway in response to dna damage
|
GO:0008630 |
57 |
0.216
|
|
|
|
regulation of nucleocytoplasmic transport
|
GO:0046822 |
73 |
0.213
|
|
|
|
negative regulation of protein serine threonine kinase activity
|
GO:0071901 |
49 |
0.213
|
|
|
|
response to reactive oxygen species
|
GO:0000302 |
56 |
0.211
|
|
|
|
negative regulation of nf kappab transcription factor activity
|
GO:0032088 |
15 |
0.209
|
|
|
|
tumor necrosis factor mediated signaling pathway
|
GO:0033209 |
13 |
0.209
|
|
|
|
segmentation
|
GO:0035282 |
93 |
0.208
|
|
|
|
embryonic skeletal system development
|
GO:0048706 |
120 |
0.205
|
|
|
|
positive regulation of intracellular transport
|
GO:0032388 |
70 |
0.204
|
|
|
|
myeloid dendritic cell differentiation
|
GO:0043011 |
16 |
0.203
|
|
|
|
positive regulation of apoptotic signaling pathway
|
GO:2001235 |
95 |
0.201
|
|
|
|
kidney mesenchyme morphogenesis
|
GO:0072131 |
4 |
0.201
|
|
|
|
positive regulation of cell cycle
|
GO:0045787 |
92 |
0.200
|
|
|
|
positive regulation of cytokine production involved in immune response
|
GO:0002720 |
19 |
0.197
|
Human |
|
|
cytokine metabolic process
|
GO:0042107 |
71 |
0.196
|
|
|
|
regulation of interferon beta production
|
GO:0032648 |
13 |
0.196
|
|
|
|
positive regulation of nucleocytoplasmic transport
|
GO:0046824 |
30 |
0.196
|
|
|
|
response to lipopolysaccharide
|
GO:0032496 |
128 |
0.192
|
Fly |
|
|
jak stat cascade
|
GO:0007259 |
42 |
0.192
|
|
|
|
positive regulation of proteolysis
|
GO:0045862 |
85 |
0.191
|
|
|
|
regulation of protein deacetylation
|
GO:0090311 |
17 |
0.190
|
|
|
|
endothelial cell activation
|
GO:0042118 |
1 |
0.188
|
|
|
|
positive regulation of osteoclast differentiation
|
GO:0045672 |
15 |
0.188
|
|
|
|
cell proliferation involved in heart valve morphogenesis
|
GO:0003249 |
1 |
0.187
|
|
|
|
nucleic acid phosphodiester bond hydrolysis
|
GO:0090305 |
49 |
0.186
|
|
|
|
cation transport
|
GO:0006812 |
399 |
0.185
|
|
|
|
regulation of proteolysis
|
GO:0030162 |
164 |
0.183
|
|
|
|
cardiac ventricle development
|
GO:0003231 |
83 |
0.182
|
|
|
|
protein import
|
GO:0017038 |
101 |
0.182
|
|
|
|
positive regulation of immature t cell proliferation
|
GO:0033091 |
4 |
0.181
|
|
|
|
cellular response to reactive nitrogen species
|
GO:1902170 |
5 |
0.181
|
|
|
|
response to molecule of bacterial origin
|
GO:0002237 |
143 |
0.179
|
Fly |
|
|
regulation of interleukin 2 production
|
GO:0032663 |
28 |
0.179
|
Human |
|
|
lymphocyte mediated immunity
|
GO:0002449 |
139 |
0.178
|
Human |
|
|
regulation of apoptotic signaling pathway
|
GO:2001233 |
197 |
0.178
|
|
|
|
striated muscle tissue development
|
GO:0014706 |
293 |
0.178
|
|
|
|
negative regulation of response to endoplasmic reticulum stress
|
GO:1903573 |
8 |
0.177
|
|
|
|
activation of mapkkk activity
|
GO:0000185 |
1 |
0.175
|
|
|
|
stem cell maintenance
|
GO:0019827 |
130 |
0.175
|
|
|
|
lens development in camera type eye
|
GO:0002088 |
62 |
0.174
|
|
|
|
striated muscle cell proliferation
|
GO:0014855 |
39 |
0.173
|
|
|
|
positive regulation of cell death
|
GO:0010942 |
224 |
0.173
|
|
|
|
morphogenesis of a branching structure
|
GO:0001763 |
203 |
0.173
|
|
|
|
regulation of system process
|
GO:0044057 |
200 |
0.172
|
|
|
|
odontogenesis of dentin containing tooth
|
GO:0042475 |
66 |
0.170
|
|
|
|
activation induced cell death of t cells
|
GO:0006924 |
10 |
0.169
|
|
|
|
regulation of mitotic cell cycle phase transition
|
GO:1901990 |
73 |
0.167
|
|
|
|
glial cell apoptotic process
|
GO:0034349 |
3 |
0.167
|
|
|
|
regulation of epithelial to mesenchymal transition
|
GO:0010717 |
22 |
0.167
|
|
|
|
ion transmembrane transport
|
GO:0034220 |
361 |
0.166
|
|
|
|
erythrocyte differentiation
|
GO:0030218 |
88 |
0.165
|
|
|
|
camera type eye development
|
GO:0043010 |
266 |
0.165
|
|
|
|
modification dependent protein catabolic process
|
GO:0019941 |
133 |
0.164
|
|
|
|
regionalization
|
GO:0003002 |
337 |
0.162
|
|
|
|
regulation of synaptic growth at neuromuscular junction
|
GO:0008582 |
4 |
0.162
|
|
|
|
negative regulation of molecular function
|
GO:0044092 |
258 |
0.162
|
|
|
|
cell fate specification
|
GO:0001708 |
72 |
0.159
|
Worm |
|
|
regulation of striated muscle contraction
|
GO:0006942 |
25 |
0.158
|
|
|
|
antimicrobial peptide production
|
GO:0002775 |
2 |
0.156
|
Fly |
|
|
regulation of jak stat cascade
|
GO:0046425 |
34 |
0.155
|
|
|
|
embryonic organ morphogenesis
|
GO:0048562 |
276 |
0.154
|
|
|
|
negative regulation of immune effector process
|
GO:0002698 |
55 |
0.153
|
|
|
|
endocardial cushion morphogenesis
|
GO:0003203 |
18 |
0.153
|
|
|
|
cellular response to nitric oxide
|
GO:0071732 |
4 |
0.153
|
|
|
|
negative regulation of response to wounding
|
GO:1903035 |
77 |
0.152
|
|
|
|
hindbrain development
|
GO:0030902 |
128 |
0.152
|
|
|
|
liver development
|
GO:0001889 |
66 |
0.151
|
|
|
|
nuclear transport
|
GO:0051169 |
139 |
0.151
|
|
|
|
ossification
|
GO:0001503 |
216 |
0.150
|
|
|
|
regulation of cytoplasmic transport
|
GO:1903649 |
112 |
0.149
|
|
|
|
muscle cell proliferation
|
GO:0033002 |
52 |
0.148
|
|
|
|
regulation of interleukin 10 secretion
|
GO:2001179 |
4 |
0.148
|
|
|
|
neuron projection guidance
|
GO:0097485 |
141 |
0.147
|
|
|
|
cellular ketone metabolic process
|
GO:0042180 |
84 |
0.145
|
|
|
|
kidney development
|
GO:0001822 |
213 |
0.145
|
|
|
|
amide transport
|
GO:0042886 |
138 |
0.144
|
|
|
|
regulation of secretion by cell
|
GO:1903530 |
249 |
0.144
|
|
|
|
innate immune response activating signal transduction
|
GO:0002758 |
50 |
0.142
|
|
|
|
tube formation
|
GO:0035148 |
140 |
0.142
|
|
|
|
intracellular protein transport
|
GO:0006886 |
204 |
0.142
|
|
|
|
protein oligomerization
|
GO:0051259 |
67 |
0.141
|
|
|
|
cell fate commitment involved in formation of primary germ layer
|
GO:0060795 |
26 |
0.140
|
Worm |
|
|
retina development in camera type eye
|
GO:0060041 |
119 |
0.138
|
|
|
|
positive regulation of cysteine type endopeptidase activity
|
GO:2001056 |
39 |
0.138
|
|
|
|
immunoglobulin production
|
GO:0002377 |
73 |
0.137
|
|
|
|
regulation of leukocyte proliferation
|
GO:0070663 |
121 |
0.136
|
|
|
|
negative regulation of t cell activation
|
GO:0050868 |
65 |
0.135
|
|
|
|
endocardial cushion formation
|
GO:0003272 |
13 |
0.135
|
|
|
|
regulation of epithelial cell proliferation
|
GO:0050678 |
141 |
0.134
|
|
|
|
positive regulation of lymphocyte proliferation
|
GO:0050671 |
70 |
0.133
|
|
|
|
positive regulation of tolerance induction
|
GO:0002645 |
8 |
0.132
|
|
|
|
somatic stem cell maintenance
|
GO:0035019 |
47 |
0.130
|
|
|
|
lymphocyte apoptotic process
|
GO:0070227 |
54 |
0.130
|
|
|
|
regulation of protein localization
|
GO:0032880 |
231 |
0.130
|
|
|
|
determination of left right symmetry
|
GO:0007368 |
80 |
0.129
|
|
|
|
regulation of lymphocyte anergy
|
GO:0002911 |
4 |
0.129
|
|
|
|
positive regulation of t cell mediated immunity
|
GO:0002711 |
24 |
0.129
|
Human |
|
|
protein targeting
|
GO:0006605 |
143 |
0.129
|
|
|
|
positive regulation of defense response to virus by host
|
GO:0002230 |
6 |
0.128
|
|
|
|
positive regulation of extrinsic apoptotic signaling pathway
|
GO:2001238 |
34 |
0.128
|
|
|
|
regulation of sodium ion transport
|
GO:0002028 |
29 |
0.128
|
|
|
|
regulation of heart contraction
|
GO:0008016 |
77 |
0.127
|
|
|
|
negative regulation of protein processing
|
GO:0010955 |
79 |
0.125
|
|
|
|
regulation of protein catabolic process
|
GO:0042176 |
108 |
0.125
|
|
|
|
regulation of b cell proliferation
|
GO:0030888 |
39 |
0.125
|
|
|
|
peptide hormone secretion
|
GO:0030072 |
109 |
0.124
|
|
|
|
regulation of intracellular transport
|
GO:0032386 |
159 |
0.123
|
|
|
|
negative regulation of cell cycle phase transition
|
GO:1901988 |
48 |
0.123
|
|
|
|
cell division
|
GO:0051301 |
120 |
0.123
|
Worm |
|
|
regulation of osteoblast differentiation
|
GO:0045667 |
67 |
0.123
|
|
|
|
regulation of cell cycle g1 s phase transition
|
GO:1902806 |
35 |
0.123
|
|
|
|
antibacterial peptide biosynthetic process
|
GO:0002780 |
2 |
0.123
|
Fly |
|
|
mammary gland epithelial cell proliferation
|
GO:0033598 |
24 |
0.123
|
|
|
|
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway
|
GO:0090101 |
61 |
0.123
|
|
|
|
negative regulation of peptidyl threonine phosphorylation
|
GO:0010801 |
6 |
0.122
|
|
|
|
chromatin modification
|
GO:0016568 |
187 |
0.121
|
Human |
|
|
positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway
|
GO:0090100 |
43 |
0.120
|
|
|
|
thymus development
|
GO:0048538 |
41 |
0.120
|
|
|
|
regulation of chromatin modification
|
GO:1903308 |
57 |
0.120
|
|
|
|
immunoglobulin mediated immune response
|
GO:0016064 |
69 |
0.120
|
|
|
|
palate development
|
GO:0060021 |
76 |
0.119
|
|
|
|
regulation of binding
|
GO:0051098 |
111 |
0.119
|
|
|
|
positive regulation of leukocyte differentiation
|
GO:1902107 |
86 |
0.118
|
|
|
|
negative regulation of transforming growth factor beta receptor signaling pathway
|
GO:0030512 |
26 |
0.117
|
|
|
|
ventricular septum morphogenesis
|
GO:0060412 |
27 |
0.117
|
|
|
|
negative regulation of peptidyl serine phosphorylation
|
GO:0033137 |
10 |
0.117
|
|
|
|
regulation of type i interferon production
|
GO:0032479 |
22 |
0.116
|
|
|
|
t cell anergy
|
GO:0002870 |
4 |
0.115
|
|
|
|
lymphocyte activation involved in immune response
|
GO:0002285 |
93 |
0.115
|
|
|
|
response to radiation
|
GO:0009314 |
165 |
0.115
|
|
|
|
response to peptide
|
GO:1901652 |
136 |
0.114
|
|
|
|
regulation of protein transport
|
GO:0051223 |
163 |
0.114
|
|
|
|
positive regulation of osteoblast differentiation
|
GO:0045669 |
34 |
0.114
|
|
|
|
leukocyte mediated immunity
|
GO:0002443 |
174 |
0.113
|
Human |
|
|
proteasomal protein catabolic process
|
GO:0010498 |
98 |
0.113
|
|
|
|
cytokine mediated signaling pathway
|
GO:0019221 |
115 |
0.113
|
|
|
|
defense response to gram negative bacterium
|
GO:0050829 |
28 |
0.113
|
Fly |
|
|
response to peptidoglycan
|
GO:0032494 |
9 |
0.112
|
|
|
|
cartilage development
|
GO:0051216 |
140 |
0.112
|
|
|
|
embryonic heart tube morphogenesis
|
GO:0003143 |
51 |
0.112
|
|
|
|
cell cycle arrest
|
GO:0007050 |
37 |
0.112
|
|
|
|
stem cell differentiation
|
GO:0048863 |
268 |
0.112
|
|
|
|
regulation of embryonic development
|
GO:0045995 |
71 |
0.111
|
|
|
|
lymphocyte anergy
|
GO:0002249 |
4 |
0.108
|
|
|
|
cellular response to lipopolysaccharide
|
GO:0071222 |
77 |
0.108
|
Fly |
|
|
appendage morphogenesis
|
GO:0035107 |
149 |
0.108
|
|
|
|
single organism nuclear import
|
GO:1902593 |
95 |
0.108
|
|
|
|
endocrine system development
|
GO:0035270 |
98 |
0.108
|
|
|
|
endocardial cushion development
|
GO:0003197 |
26 |
0.108
|
|
|
|
regulation of protein secretion
|
GO:0050708 |
82 |
0.107
|
|
|
|
regulation of ion transport
|
GO:0043269 |
215 |
0.107
|
|
|
|
meiotic cell cycle
|
GO:0051321 |
122 |
0.106
|
|
|
|
necroptotic process
|
GO:0070266 |
21 |
0.106
|
|
|
|
positive regulation of antimicrobial peptide biosynthetic process
|
GO:0002807 |
1 |
0.106
|
Fly |
|
|
proteasome mediated ubiquitin dependent protein catabolic process
|
GO:0043161 |
88 |
0.106
|
|
|
|
cardiac chamber morphogenesis
|
GO:0003206 |
93 |
0.106
|
|
|
|
regulation of epidermis development
|
GO:0045682 |
33 |
0.106
|
|
|
|
regulation of body fluid levels
|
GO:0050878 |
162 |
0.105
|
|
|
|
positive regulation of t cell cytokine production
|
GO:0002726 |
5 |
0.105
|
Human |
|
|
morphogenesis of a branching epithelium
|
GO:0061138 |
193 |
0.105
|
|
|
|
mesoderm development
|
GO:0007498 |
100 |
0.104
|
|
|
|
organ growth
|
GO:0035265 |
117 |
0.104
|
|
|
|
regulation of protein ubiquitination
|
GO:0031396 |
52 |
0.104
|
|
|
|
somitogenesis
|
GO:0001756 |
69 |
0.104
|
|
|
|
regulation of antibacterial peptide production
|
GO:0002786 |
1 |
0.103
|
Fly |
|
|
osteoclast differentiation
|
GO:0030316 |
62 |
0.103
|
|
|
|
response to nitric oxide
|
GO:0071731 |
4 |
0.102
|
|
|
|
negative regulation of osteoblast differentiation
|
GO:0045668 |
30 |
0.101
|
|
|
|
positive regulation of cell morphogenesis involved in differentiation
|
GO:0010770 |
72 |
0.101
|
|
|
|
cellular response to hormone stimulus
|
GO:0032870 |
150 |
0.101
|
|
|
|
negative regulation of interleukin 13 production
|
GO:0032696 |
2 |
0.100
|
|
|
|
nephron tubule development
|
GO:0072080 |
84 |
0.099
|
|
|
|
nucleocytoplasmic transport
|
GO:0006913 |
139 |
0.099
|
|
|
|
cardiac muscle tissue growth
|
GO:0055017 |
37 |
0.098
|
|
|
|
blood circulation
|
GO:0008015 |
195 |
0.097
|
|
|
|
metanephric mesenchyme morphogenesis
|
GO:0072133 |
4 |
0.095
|
|
|
|
mesonephric epithelium development
|
GO:0072163 |
94 |
0.095
|
|
|
|
negative regulation of bmp signaling pathway
|
GO:0030514 |
35 |
0.093
|
|
|
|
embryonic skeletal system morphogenesis
|
GO:0048704 |
91 |
0.093
|
|
|
|
regulation of transmembrane receptor protein serine threonine kinase signaling pathway
|
GO:0090092 |
112 |
0.092
|
|
|
|
regulation of chromatin organization
|
GO:1902275 |
57 |
0.092
|
|
|
|
positive regulation of meiotic cell cycle
|
GO:0051446 |
15 |
0.092
|
|
|
|
negative regulation of inflammatory response
|
GO:0050728 |
61 |
0.091
|
|
|
|
embryonic axis specification
|
GO:0000578 |
30 |
0.091
|
|
|
|
regulation of inflammatory response
|
GO:0050727 |
147 |
0.091
|
|
|
|
negative regulation of mitotic cell cycle
|
GO:0045930 |
58 |
0.090
|
|
|
|
cardiac septum development
|
GO:0003279 |
59 |
0.090
|
|
|
|
multicellular organism growth
|
GO:0035264 |
161 |
0.090
|
|
|
|
covalent chromatin modification
|
GO:0016569 |
163 |
0.090
|
Human |
|
|
interleukin 10 secretion
|
GO:0072608 |
4 |
0.090
|
|
|
|
positive regulation of intrinsic apoptotic signaling pathway
|
GO:2001244 |
25 |
0.089
|
|
|
|
cardiac muscle contraction
|
GO:0060048 |
32 |
0.089
|
|
|
|
regulation of cell proliferation involved in heart valve morphogenesis
|
GO:0003250 |
1 |
0.089
|
|
|
|
cellular response to organic cyclic compound
|
GO:0071407 |
87 |
0.089
|
|
|
|
regulation of cellular catabolic process
|
GO:0031329 |
242 |
0.089
|
Fly |
|
|
regulation of cd8 positive alpha beta cytotoxic t cell extravasation
|
GO:2000452 |
2 |
0.088
|
|
|
|
protein acylation
|
GO:0043543 |
64 |
0.088
|
Human |
|
|
regulation of histone modification
|
GO:0031056 |
56 |
0.088
|
|
|
|
positive regulation of protein oligomerization
|
GO:0032461 |
4 |
0.087
|
|
|
|
negative regulation of map kinase activity
|
GO:0043407 |
34 |
0.087
|
|
|
|
nephron development
|
GO:0072006 |
109 |
0.086
|
|
|
|
positive regulation of myeloid cell differentiation
|
GO:0045639 |
43 |
0.086
|
|
|
|
multicellular organismal homeostasis
|
GO:0048871 |
164 |
0.085
|
|
|
|
positive regulation of growth
|
GO:0045927 |
104 |
0.085
|
|
|
|
regulation of leukocyte differentiation
|
GO:1902105 |
159 |
0.085
|
|
|
|
microtubule based process
|
GO:0007017 |
236 |
0.084
|
|
|
|
cardiac muscle cell proliferation
|
GO:0060038 |
31 |
0.084
|
|
|
|
chondrocyte differentiation
|
GO:0002062 |
72 |
0.084
|
|
|
|
interleukin 2 production
|
GO:0032623 |
33 |
0.084
|
Human |
