Mus musculus

29 known processes

Map4k1

mitogen-activated protein kinase kinase kinase kinase 1

(Aliases: mHPK1,Hpk1)

Map4k1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
actin polymerization or depolymerization GO:0008154 54 0.690
regulation of actin filament polymerization GO:0030833 38 0.635
fibroblast growth factor receptor signaling pathway GO:0008543 46 0.612
regulation of actin filament length GO:0030832 45 0.587
cellular amine metabolic process GO:0044106 44 0.572
actin filament polymerization GO:0030041 44 0.473
regulation of actin polymerization or depolymerization GO:0008064 45 0.417
small gtpase mediated signal transduction GO:0007264 97 0.409
regulation of cellular amine metabolic process GO:0033238 20 0.409
negative regulation of cellular amine metabolic process GO:0033239 1 0.378
cellular protein complex assembly GO:0043623 116 0.343
regulation of cellular component size GO:0032535 121 0.343
Fly
negative regulation of epidermal growth factor activated receptor activity GO:0007175 3 0.317
cellular response to growth factor stimulus GO:0071363 197 0.295
regulation of anatomical structure size GO:0090066 178 0.282
Fly
regulation of cytoskeleton organization GO:0051493 122 0.271
positive regulation of organelle organization GO:0010638 128 0.270
ras protein signal transduction GO:0007265 77 0.263
muscle cell differentiation GO:0042692 261 0.241
cellular ketone metabolic process GO:0042180 84 0.234
negative regulation of molecular function GO:0044092 258 0.233
negative regulation of kinase activity GO:0033673 81 0.226
negative regulation of protein metabolic process GO:0051248 282 0.207
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.205
cellular amino acid metabolic process GO:0006520 103 0.203
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.187
divalent metal ion transport GO:0070838 172 0.182
actin cytoskeleton organization GO:0030036 220 0.182
regulation of cell projection organization GO:0031344 206 0.178
protein polymerization GO:0051258 57 0.172
calcium ion transport GO:0006816 159 0.172
negative regulation of phosphorylation GO:0042326 166 0.166
regulation of protein complex assembly GO:0043254 83 0.165
regulation of cellular ketone metabolic process GO:0010565 66 0.164
regulation of calcium ion transport GO:0051924 69 0.152
peptidyl tyrosine phosphorylation GO:0018108 143 0.151
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.148
cation transport GO:0006812 399 0.144
positive regulation of actin filament polymerization GO:0030838 26 0.141
amine metabolic process GO:0009308 45 0.141
divalent inorganic cation transport GO:0072511 178 0.141
regulation of cellular amino acid metabolic process GO:0006521 5 0.139
regulation of kinase activity GO:0043549 249 0.135
Human
regulation of ion transport GO:0043269 215 0.135
cytokine production GO:0001816 319 0.134
regulation of organelle organization GO:0033043 289 0.133
cognition GO:0050890 149 0.132
associative learning GO:0008306 61 0.129
memory GO:0007613 58 0.118
mast cell activation GO:0045576 27 0.118
regulation of actin filament based process GO:0032970 99 0.116
peptidyl tyrosine modification GO:0018212 145 0.115
negative regulation of peptidyl tyrosine phosphorylation GO:0050732 17 0.111
response to growth factor GO:0070848 198 0.109
olfactory learning GO:0008355 2 0.107
sensory perception GO:0007600 245 0.107
negative regulation of protein tyrosine kinase activity GO:0061099 3 0.107
gland development GO:0048732 330 0.104
learning or memory GO:0007611 148 0.102
negative regulation of protein phosphorylation GO:0001933 126 0.102
negative regulation of phosphorus metabolic process GO:0010563 184 0.102
negative regulation of cellular protein metabolic process GO:0032269 247 0.101
substrate adhesion dependent cell spreading GO:0034446 30 0.101
t cell activation GO:0042110 289 0.097
negative regulation of receptor activity GO:2000272 5 0.094
positive regulation of gtp catabolic process GO:0033126 85 0.093
microtubule based process GO:0007017 236 0.093
negative regulation of protein modification process GO:0031400 163 0.092
positive regulation of cell development GO:0010720 237 0.092
cellular response to cytokine stimulus GO:0071345 189 0.088
positive regulation of cytoskeleton organization GO:0051495 49 0.087
purine nucleoside catabolic process GO:0006152 205 0.087
nucleoside triphosphate metabolic process GO:0009141 230 0.085
regulation of protein kinase activity GO:0045859 232 0.082
Human
positive regulation of neuron differentiation GO:0045666 141 0.082
regulation of neuron projection development GO:0010975 169 0.082
regulation of binding GO:0051098 111 0.081
microtubule cytoskeleton organization GO:0000226 157 0.079
dna metabolic process GO:0006259 303 0.077
gonad development GO:0008406 141 0.076
regulation of cell shape GO:0008360 39 0.076
negative regulation of epidermal growth factor receptor signaling pathway GO:0042059 6 0.074
Fly
cytoplasmic transport GO:0016482 234 0.073
epithelial tube morphogenesis GO:0060562 303 0.072
regulation of actin cytoskeleton organization GO:0032956 84 0.072
actin filament organization GO:0007015 113 0.071
regulation of peptidyl tyrosine phosphorylation GO:0050730 93 0.071
cellular component assembly involved in morphogenesis GO:0010927 139 0.069
maintenance of location GO:0051235 89 0.069
mitotic cell cycle process GO:1903047 159 0.067
myeloid leukocyte activation GO:0002274 83 0.067
positive regulation of cellular amine metabolic process GO:0033240 5 0.066
learning GO:0007612 98 0.066
regulation of cell activation GO:0050865 289 0.064
negative regulation of cell proliferation GO:0008285 296 0.064
nucleoside phosphate catabolic process GO:1901292 222 0.063
macromolecule catabolic process GO:0009057 281 0.063
protein localization to membrane GO:0072657 108 0.062
negative regulation of transferase activity GO:0051348 85 0.062
sensory perception of mechanical stimulus GO:0050954 107 0.061
lymphocyte differentiation GO:0030098 242 0.061
leukocyte mediated immunity GO:0002443 174 0.061
regulation of apoptotic signaling pathway GO:2001233 197 0.061
immune effector process GO:0002252 321 0.060
membrane organization GO:0061024 245 0.060
b cell activation GO:0042113 161 0.059
organelle assembly GO:0070925 177 0.059
muscle tissue development GO:0060537 308 0.059
meiotic nuclear division GO:0007126 115 0.058
protein processing GO:0016485 163 0.058
response to organonitrogen compound GO:0010243 246 0.058
Fly
endomembrane system organization GO:0010256 147 0.057
Fly
positive regulation of protein modification process GO:0031401 299 0.056
Human
antigen receptor mediated signaling pathway GO:0050851 64 0.056
regulation of protein binding GO:0043393 60 0.055
development of primary sexual characteristics GO:0045137 143 0.055
cellular homeostasis GO:0019725 240 0.055
nucleoside triphosphate catabolic process GO:0009143 205 0.054
positive regulation of neuron projection development GO:0010976 79 0.054
nucleotide catabolic process GO:0009166 217 0.052
regulation of epidermal growth factor activated receptor activity GO:0007176 7 0.051
regulation of endopeptidase activity GO:0052548 89 0.050
positive regulation of cellular component biogenesis GO:0044089 94 0.050
regulation of t cell activation GO:0050863 170 0.050
t cell proliferation GO:0042098 120 0.049
cell type specific apoptotic process GO:0097285 268 0.049
regulation of leukocyte differentiation GO:1902105 159 0.049
chemotaxis GO:0006935 247 0.048
response to transforming growth factor beta GO:0071559 88 0.048
protein maturation GO:0051604 176 0.048
synaptic transmission GO:0007268 329 0.048
organic hydroxy compound metabolic process GO:1901615 203 0.047
digestive tract development GO:0048565 190 0.047
cellular nitrogen compound catabolic process GO:0044270 280 0.047
calcium ion transport into cytosol GO:0060402 48 0.046
regulation of epidermal growth factor receptor signaling pathway GO:0042058 13 0.046
Fly
negative regulation of phosphate metabolic process GO:0045936 184 0.046
positive regulation of protein phosphorylation GO:0001934 242 0.046
Human
mapk cascade GO:0000165 281 0.045
Human Fly
synapse organization GO:0050808 125 0.044
cell maturation GO:0048469 127 0.044
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.044
Fly
regulation of cysteine type endopeptidase activity GO:2000116 65 0.043
regulation of cell cycle process GO:0010564 160 0.042
regulation of hydrolase activity GO:0051336 246 0.042
t cell differentiation in thymus GO:0033077 77 0.042
cell growth GO:0016049 130 0.042
purine nucleoside triphosphate catabolic process GO:0009146 203 0.042
cell adhesion GO:0007155 329 0.041
peptidyl serine phosphorylation GO:0018105 74 0.041
Human
protein catabolic process GO:0030163 221 0.041
ameboidal type cell migration GO:0001667 128 0.041
regulation of transferase activity GO:0051338 263 0.040
Human
negative regulation of intracellular signal transduction GO:1902532 167 0.040
male gamete generation GO:0048232 285 0.040
morphogenesis of a branching structure GO:0001763 203 0.040
compound eye development GO:0048749 1 0.040
embryonic placenta development GO:0001892 98 0.039
establishment or maintenance of cell polarity GO:0007163 86 0.039
positive regulation of cell death GO:0010942 224 0.039
Fly
peptidyl amino acid modification GO:0018193 336 0.039
Human
epithelium migration GO:0090132 63 0.039
extrinsic apoptotic signaling pathway GO:0097191 126 0.038
positive regulation of mapk cascade GO:0043410 170 0.038
Human Fly
regulation of mast cell proliferation GO:0070666 4 0.038
metal ion homeostasis GO:0055065 189 0.038
lymphocyte homeostasis GO:0002260 64 0.038
positive regulation of apoptotic process GO:0043065 217 0.038
Fly
platelet aggregation GO:0070527 20 0.038
digestive system development GO:0055123 200 0.038
b cell proliferation GO:0042100 53 0.038
heterocycle catabolic process GO:0046700 280 0.038
regulation of cellular component biogenesis GO:0044087 181 0.038
regulation of proteolysis GO:0030162 164 0.038
aromatic compound catabolic process GO:0019439 286 0.038
rho protein signal transduction GO:0007266 32 0.038
vesicle organization GO:0016050 60 0.037
cellular lipid metabolic process GO:0044255 323 0.037
regulation of protein tyrosine kinase activity GO:0061097 17 0.037
morphogenesis of embryonic epithelium GO:0016331 159 0.037
positive regulation of t cell activation GO:0050870 101 0.036
cellular divalent inorganic cation homeostasis GO:0072503 127 0.036
regulation of neuron differentiation GO:0045664 281 0.036
ribonucleoside triphosphate metabolic process GO:0009199 220 0.036
cellular metal ion homeostasis GO:0006875 151 0.036
oocyte construction GO:0007308 2 0.036
striated muscle cell development GO:0055002 125 0.036
positive t cell selection GO:0043368 23 0.035
exocytosis GO:0006887 121 0.035
regulation of cell division GO:0051302 76 0.035
negative regulation of homeostatic process GO:0032845 71 0.035
regulation of metal ion transport GO:0010959 106 0.034
regulation of protein catabolic process GO:0042176 108 0.034
homeostasis of number of cells GO:0048872 210 0.034
ribonucleoside catabolic process GO:0042454 206 0.034
regulation of lymphocyte activation GO:0051249 240 0.034
labyrinthine layer development GO:0060711 49 0.034
mast cell proliferation GO:0070662 4 0.033
sequestering of metal ion GO:0051238 19 0.033
dendrite development GO:0016358 115 0.033
homotypic cell cell adhesion GO:0034109 28 0.032
nucleobase containing small molecule metabolic process GO:0055086 352 0.032
negative regulation of nervous system development GO:0051961 156 0.032
meiotic cell cycle GO:0051321 122 0.032
epithelial cell development GO:0002064 159 0.032
positive regulation of programmed cell death GO:0043068 218 0.031
Fly
regulation of lymphocyte apoptotic process GO:0070228 41 0.031
placenta development GO:0001890 140 0.031
ion transmembrane transport GO:0034220 361 0.031
muscle fiber development GO:0048747 76 0.031
leukocyte proliferation GO:0070661 172 0.031
cellular response to dna damage stimulus GO:0006974 207 0.031
muscle cell development GO:0055001 133 0.031
cellular ion homeostasis GO:0006873 165 0.030
transmembrane transport GO:0055085 412 0.030
regulation of erbb signaling pathway GO:1901184 16 0.029
Fly
regulation of cell motility GO:2000145 236 0.029
mitotic cell cycle GO:0000278 195 0.029
regulation of homeostatic process GO:0032844 182 0.029
purine nucleotide catabolic process GO:0006195 211 0.029
regulation of defense response to virus GO:0050688 18 0.029
glycosyl compound catabolic process GO:1901658 206 0.029
leukocyte migration GO:0050900 124 0.028
regulation of asymmetric cell division GO:0009786 4 0.028
inorganic cation transmembrane transport GO:0098662 207 0.028
leukocyte homeostasis GO:0001776 79 0.028
purine nucleoside triphosphate metabolic process GO:0009144 226 0.028
leukocyte differentiation GO:0002521 342 0.028
female gamete generation GO:0007292 74 0.028
negative regulation of protein serine threonine kinase activity GO:0071901 49 0.028
positive regulation of protein complex assembly GO:0031334 45 0.028
cell fate commitment GO:0045165 210 0.028
negative regulation of apoptotic signaling pathway GO:2001234 104 0.028
carbohydrate derivative catabolic process GO:1901136 231 0.028
cytokine secretion GO:0050663 72 0.027
b cell apoptotic process GO:0001783 19 0.027
positive regulation of transferase activity GO:0051347 167 0.027
Human
sequestering of calcium ion GO:0051208 18 0.027
organic cyclic compound catabolic process GO:1901361 295 0.027
signal transduction involved in dna damage checkpoint GO:0072422 3 0.027
developmental growth involved in morphogenesis GO:0060560 138 0.027
developmental cell growth GO:0048588 84 0.027
mesodermal cell migration GO:0008078 4 0.027
glycosyl compound metabolic process GO:1901657 246 0.027
protein localization to organelle GO:0033365 185 0.027
plasma membrane organization GO:0007009 90 0.027
negative regulation of synapse assembly GO:0051964 3 0.026
positive regulation of interleukin 8 secretion GO:2000484 1 0.026
neuron projection extension GO:1990138 64 0.026
stem cell development GO:0048864 219 0.026
regionalization GO:0003002 337 0.026
positive regulation of cysteine type endopeptidase activity GO:2001056 39 0.026
regulation of blood circulation GO:1903522 93 0.026
heart process GO:0003015 94 0.026
phospholipid metabolic process GO:0006644 87 0.026
multicellular organismal signaling GO:0035637 91 0.026
regulation of phospholipase c activity GO:1900274 3 0.025
ribonucleoside metabolic process GO:0009119 245 0.025
regulation of membrane potential GO:0042391 192 0.025
nuclear division GO:0000280 158 0.025
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.025
organelle fission GO:0048285 170 0.025
regulation of cell growth GO:0001558 91 0.025
stem cell differentiation GO:0048863 268 0.025
cellular response to transforming growth factor beta stimulus GO:0071560 88 0.025
nucleotide metabolic process GO:0009117 332 0.025
positive regulation of hydrolase activity GO:0051345 148 0.024
intracellular mrna localization GO:0008298 4 0.024
muscle system process GO:0003012 141 0.023
nucleoside catabolic process GO:0009164 206 0.023
positive regulation of cell motility GO:2000147 116 0.023
striated muscle contraction GO:0006941 45 0.023
integrin mediated signaling pathway GO:0007229 27 0.023
purine containing compound catabolic process GO:0072523 213 0.023
cardiac muscle tissue development GO:0048738 130 0.023
axonogenesis GO:0007409 274 0.023
gamma delta t cell activation GO:0046629 13 0.023
apoptotic signaling pathway GO:0097190 306 0.023
regulation of dendritic cell apoptotic process GO:2000668 3 0.023
clathrin coat assembly GO:0048268 2 0.023
protein autophosphorylation GO:0046777 61 0.022
Human
detection of mechanical stimulus involved in sensory perception GO:0050974 23 0.022
cell chemotaxis GO:0060326 81 0.022
actin filament based movement GO:0030048 23 0.022
b cell homeostasis GO:0001782 34 0.022
regulation of cell size GO:0008361 72 0.022
Fly
single organismal cell cell adhesion GO:0016337 131 0.022
adaptive immune response GO:0002250 155 0.022
posttranscriptional regulation of gene expression GO:0010608 155 0.022
regulation of secretion GO:0051046 274 0.022
actin filament bundle assembly GO:0051017 40 0.022
negative regulation of ras protein signal transduction GO:0046580 18 0.022
central nervous system neuron differentiation GO:0021953 162 0.022
calcium ion transmembrane transport GO:0070588 85 0.022
skin development GO:0043588 220 0.022
positive regulation of apoptotic signaling pathway GO:2001235 95 0.021
cation homeostasis GO:0055080 212 0.021
positive regulation of interferon gamma secretion GO:1902715 3 0.021
limbic system development GO:0021761 72 0.021
nucleoside phosphate metabolic process GO:0006753 338 0.021
positive regulation of purine nucleotide catabolic process GO:0033123 88 0.021
neuron migration GO:0001764 122 0.021
positive regulation of transcription from rna polymerase ii promoter involved in smooth muscle cell differentiation GO:2000721 2 0.021
organelle localization GO:0051640 179 0.021
Mouse
positive regulation of cell activation GO:0050867 158 0.021
positive regulation of inositol phosphate biosynthetic process GO:0060732 2 0.021
forebrain development GO:0030900 302 0.021
protein modification by small protein conjugation GO:0032446 187 0.021
glial cell differentiation GO:0010001 131 0.021
regulation of erythrocyte differentiation GO:0045646 23 0.021
positive regulation of dendritic cell apoptotic process GO:2000670 3 0.021
positive regulation of cytosolic calcium ion concentration GO:0007204 65 0.021
lymphocyte proliferation GO:0046651 164 0.021
cellular calcium ion homeostasis GO:0006874 119 0.021
positive regulation of germinal center formation GO:0002636 5 0.020
single organism cell adhesion GO:0098602 156 0.020
ribonucleotide metabolic process GO:0009259 291 0.020
positive regulation of nervous system development GO:0051962 221 0.020
macromolecule glycosylation GO:0043413 55 0.020
carbohydrate metabolic process GO:0005975 230 0.020
purine ribonucleotide metabolic process GO:0009150 290 0.020
establishment or maintenance of microtubule cytoskeleton polarity GO:0030951 1 0.020
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.020
wound healing GO:0042060 157 0.020
microtubule based movement GO:0007018 84 0.020
cellular chemical homeostasis GO:0055082 215 0.019
negative regulation of cell migration GO:0030336 59 0.019
muscle contraction GO:0006936 101 0.019
nucleocytoplasmic transport GO:0006913 139 0.019
positive regulation of proteolysis GO:0045862 85 0.019
tor signaling GO:0031929 21 0.019
Fly
regulation of lymphocyte proliferation GO:0050670 117 0.019
cell fate specification GO:0001708 72 0.019
dephosphorylation GO:0016311 129 0.019
sensitization GO:0046960 2 0.019
skeletal muscle organ development GO:0060538 163 0.019
regulation of ion transmembrane transporter activity GO:0032412 54 0.019
response to radiation GO:0009314 165 0.019
tissue homeostasis GO:0001894 115 0.019
epidermal growth factor receptor signaling pathway GO:0007173 28 0.019
Fly
branching involved in labyrinthine layer morphogenesis GO:0060670 9 0.019
regulation of cell migration GO:0030334 219 0.019
cilium morphogenesis GO:0060271 102 0.019
striated muscle tissue development GO:0014706 293 0.019
cell substrate adhesion GO:0031589 130 0.019
ribonucleoside triphosphate catabolic process GO:0009203 199 0.019
sphingosine 1 phosphate signaling pathway GO:0003376 3 0.019
anatomical structure homeostasis GO:0060249 145 0.019
purine ribonucleotide catabolic process GO:0009154 208 0.019
detection of mechanical stimulus GO:0050982 27 0.019
regulation of protein maturation GO:1903317 96 0.018
regulation of lymphocyte differentiation GO:0045619 107 0.018
signal transduction by p53 class mediator GO:0072331 51 0.018
apical constriction GO:0003383 4 0.018
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 62 0.018
alcohol metabolic process GO:0006066 116 0.018
organophosphate catabolic process GO:0046434 232 0.018
positive regulation of cell projection organization GO:0031346 95 0.018
embryonic epithelial tube formation GO:0001838 130 0.018
compartment pattern specification GO:0007386 4 0.018
positive regulation of podosome assembly GO:0071803 3 0.018
transforming growth factor beta receptor signaling pathway GO:0007179 71 0.018
purine nucleotide metabolic process GO:0006163 302 0.018
positive regulation of transcription via serum response element binding GO:0010735 1 0.018
dendritic cell apoptotic process GO:0097048 3 0.018
regulation of ion homeostasis GO:2000021 64 0.018
blood vessel morphogenesis GO:0048514 285 0.018
regulation of intracellular transport GO:0032386 159 0.018
inorganic ion transmembrane transport GO:0098660 234 0.018
gliogenesis GO:0042063 141 0.018
lymphocyte apoptotic process GO:0070227 54 0.018
digestive tract morphogenesis GO:0048546 147 0.018
actin mediated cell contraction GO:0070252 15 0.018
telencephalon development GO:0021537 186 0.018
tolerance induction to self antigen GO:0002513 4 0.018
positive regulation of leukocyte differentiation GO:1902107 86 0.018
regulation of endocytosis GO:0030100 69 0.017
positive regulation of nucleotide catabolic process GO:0030813 88 0.017
axon guidance GO:0007411 141 0.017
oocyte axis specification GO:0007309 2 0.017
substrate dependent cell migration cell extension GO:0006930 4 0.017
positive regulation of ion transmembrane transporter activity GO:0032414 15 0.017
membrane lipid metabolic process GO:0006643 53 0.017
b cell activation involved in immune response GO:0002312 50 0.017
sensory system development GO:0048880 3 0.017
b cell receptor signaling pathway GO:0050853 20 0.017
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 61 0.017
immune response activating cell surface receptor signaling pathway GO:0002429 72 0.017
dendritic spine maintenance GO:0097062 4 0.017
oocyte anterior posterior axis specification GO:0007314 2 0.017
glycosylation GO:0070085 62 0.017
establishment or maintenance of cytoskeleton polarity GO:0030952 2 0.017
peptidyl serine modification GO:0018209 83 0.017
Human
regulation of mapk cascade GO:0043408 248 0.017
Human Fly
cellular carbohydrate metabolic process GO:0044262 119 0.017
regulation of arp2 3 complex mediated actin nucleation GO:0034315 1 0.017
cilium assembly GO:0042384 81 0.017
striated muscle myosin thick filament assembly GO:0071688 1 0.017
sensory perception of chemical stimulus GO:0007606 51 0.017
negative regulation of b cell activation GO:0050869 27 0.017
regulation of neuron death GO:1901214 134 0.017
embryonic skeletal system development GO:0048706 120 0.017
response to metal ion GO:0010038 47 0.017
regulation of vesicle mediated transport GO:0060627 139 0.017
positive regulation of phospholipase c activity GO:0010863 2 0.017
formation of radial glial scaffolds GO:0021943 4 0.017
regulation of myeloid cell differentiation GO:0045637 96 0.016
regulation of ras protein signal transduction GO:0046578 114 0.016
g1 s transition of mitotic cell cycle GO:0000082 57 0.016
morphogenesis of a branching epithelium GO:0061138 193 0.016
regulation of leukocyte apoptotic process GO:2000106 56 0.016
positive regulation of ion transmembrane transport GO:0034767 24 0.016
modification dependent protein catabolic process GO:0019941 133 0.016
mitotic cytokinesis GO:0000281 4 0.016
defense response to virus GO:0051607 68 0.016
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.016
Human
myeloid cell homeostasis GO:0002262 114 0.016
regulation of mitotic cell cycle GO:0007346 126 0.016
epithelial cell migration GO:0010631 63 0.016
oogenesis GO:0048477 56 0.016
positive regulation of myeloid leukocyte differentiation GO:0002763 26 0.016
hair cell differentiation GO:0035315 40 0.016
alpha beta t cell lineage commitment GO:0002363 7 0.016
regulation of wnt signaling pathway GO:0030111 123 0.016
negative regulation of protein catabolic process GO:0042177 36 0.016
single fertilization GO:0007338 82 0.016
regulation of actin nucleation GO:0051125 4 0.015
regulation of receptor activity GO:0010469 41 0.015
locomotory behavior GO:0007626 195 0.015
regulation of nucleotide catabolic process GO:0030811 122 0.015
detection of abiotic stimulus GO:0009582 60 0.015
nuclear transport GO:0051169 139 0.015
branching morphogenesis of an epithelial tube GO:0048754 159 0.015
regulation of interleukin 8 secretion GO:2000482 2 0.015
cytokine mediated signaling pathway GO:0019221 115 0.015
regulation of lipid metabolic process GO:0019216 118 0.015
response to extracellular stimulus GO:0009991 127 0.015
positive regulation of transmembrane transport GO:0034764 29 0.015
negative regulation of mast cell proliferation GO:0070667 1 0.015
positive regulation of protein kinase activity GO:0045860 144 0.015
Human
regulation of calcium ion transmembrane transporter activity GO:1901019 20 0.015
establishment of organelle localization GO:0051656 122 0.015
Mouse
purine ribonucleoside catabolic process GO:0046130 205 0.015
epithelial tube formation GO:0072175 130 0.015
spermatid development GO:0007286 108 0.015
establishment of protein localization to organelle GO:0072594 118 0.015
negative regulation of cell development GO:0010721 169 0.015
skeletal system development GO:0001501 356 0.015
cellular component maintenance GO:0043954 11 0.015
myotube differentiation GO:0014902 105 0.015
regulation of striated muscle cell differentiation GO:0051153 81 0.015
organonitrogen compound biosynthetic process GO:1901566 192 0.015
tube closure GO:0060606 91 0.015
response to temperature stimulus GO:0009266 55 0.014
t cell selection GO:0045058 34 0.014
purine nucleoside metabolic process GO:0042278 241 0.014
g protein coupled receptor signaling pathway GO:0007186 243 0.014
negative regulation of myeloid dendritic cell activation GO:0030886 3 0.014
response to inorganic substance GO:0010035 96 0.014
urogenital system development GO:0001655 261 0.014
microglia differentiation GO:0014004 2 0.014
multicellular organism growth GO:0035264 161 0.014
coagulation GO:0050817 78 0.014
response to light stimulus GO:0009416 135 0.014
dna endoreduplication GO:0042023 4 0.014
response to interferon gamma GO:0034341 34 0.014
immune response inhibiting signal transduction GO:0002765 4 0.014
cell cell junction organization GO:0045216 72 0.014
regulation of system process GO:0044057 200 0.014
alpha beta t cell activation GO:0046631 91 0.014
cell activation involved in immune response GO:0002263 126 0.014
retina development in camera type eye GO:0060041 119 0.014
b cell mediated immunity GO:0019724 71 0.014
cardiocyte differentiation GO:0035051 87 0.014
citrulline metabolic process GO:0000052 3 0.014
intracellular protein transport GO:0006886 204 0.014
cation transmembrane transport GO:0098655 266 0.014
cell cycle g1 s phase transition GO:0044843 57 0.014
regulation of cell adhesion GO:0030155 154 0.014
cytosolic calcium ion transport GO:0060401 48 0.014
cellular protein catabolic process GO:0044257 155 0.014
epithelial cell morphogenesis GO:0003382 41 0.014
leukocyte chemotaxis GO:0030595 69 0.014
mating GO:0007618 27 0.014
interleukin 8 secretion GO:0072606 3 0.014

Map4k1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
primary immunodeficiency disease DOID:612 0 0.160
immune system disease DOID:2914 0 0.160
disease of anatomical entity DOID:7 0 0.160
b cell deficiency DOID:2115 0 0.053
hematopoietic system disease DOID:74 0 0.027
blood protein disease DOID:620 0 0.021
gastrointestinal system cancer DOID:3119 0 0.020
intestinal cancer DOID:10155 0 0.020
cancer DOID:162 0 0.020
disease of cellular proliferation DOID:14566 0 0.020
organ system cancer DOID:0050686 0 0.020
agammaglobulinemia DOID:2583 0 0.014