Mus musculus

102 known processes

Mapkapk2

MAP kinase-activated protein kinase 2

(Aliases: Rps6kc1,AA960234,MK2)

Mapkapk2 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
cellular response to arsenic containing substance GO:0071243 4 0.995
p38mapk cascade GO:0038066 4 0.987
osmosensory signaling pathway GO:0007231 1 0.843
myoblast differentiation involved in skeletal muscle regeneration GO:0014835 3 0.718
regulation of nuclear cell cycle dna replication GO:0033262 2 0.703
oxidation reduction process GO:0055114 342 0.703
mapk cascade GO:0000165 281 0.633
Fly
response to lipopolysaccharide GO:0032496 128 0.618
response to superoxide GO:0000303 16 0.601
response to reactive oxygen species GO:0000302 56 0.570
cellular response to nitric oxide GO:0071732 4 0.560
inflammatory response GO:0006954 244 0.528
response to oxidative stress GO:0006979 123 0.524
cellular response to osmotic stress GO:0071470 7 0.524
response to osmotic stress GO:0006970 21 0.520
Fly
intracellular protein transport GO:0006886 204 0.520
ras protein signal transduction GO:0007265 77 0.497
Mouse
cellular response to lipid GO:0071396 145 0.497
apoptotic signaling pathway GO:0097190 306 0.485
regulation of innate immune response GO:0045088 91 0.477
peptidyl threonine phosphorylation GO:0018107 31 0.475
hyperosmotic response GO:0006972 4 0.453
actin cytoskeleton organization GO:0030036 220 0.451
response to molecule of bacterial origin GO:0002237 143 0.444
peptidyl threonine modification GO:0018210 31 0.399
regulation of wnt signaling pathway GO:0030111 123 0.397
ossification GO:0001503 216 0.397
response to oxygen radical GO:0000305 16 0.395
positive regulation of transcription from rna polymerase ii promoter in response to stress GO:0036003 3 0.391
endomembrane system organization GO:0010256 147 0.363
cellular amino acid metabolic process GO:0006520 103 0.360
regulation of terminal button organization GO:2000331 1 0.359
fatty acid oxidation GO:0019395 28 0.348
response to sterol GO:0036314 4 0.336
peptidyl serine modification GO:0018209 83 0.328
Human
central nervous system neuron development GO:0021954 67 0.324
fat cell differentiation GO:0045444 160 0.323
central nervous system neuron differentiation GO:0021953 162 0.318
response to nitric oxide GO:0071731 4 0.317
negative regulation of phosphorylation GO:0042326 166 0.314
wnt signaling pathway GO:0016055 188 0.311
positive regulation of protein phosphorylation GO:0001934 242 0.310
regulation of cell migration GO:0030334 219 0.308
regulation of defense response GO:0031347 233 0.303
interleukin 5 secretion GO:0072603 2 0.303
spermatogenesis GO:0007283 284 0.300
regulation of brown fat cell differentiation GO:0090335 5 0.296
cellular amine metabolic process GO:0044106 44 0.286
regulation of antimicrobial humoral response GO:0002759 3 0.284
positive regulation of protein modification process GO:0031401 299 0.283
response to alkaloid GO:0043279 34 0.280
cellular response to reactive nitrogen species GO:1902170 5 0.280
carbohydrate metabolic process GO:0005975 230 0.276
positive regulation of brown fat cell differentiation GO:0090336 4 0.274
regulation of interleukin 10 secretion GO:2001179 4 0.272
nucleoside phosphate metabolic process GO:0006753 338 0.267
protein modification by small protein conjugation GO:0032446 187 0.265
synapse organization GO:0050808 125 0.261
response to organonitrogen compound GO:0010243 246 0.255
regulation of cellular ketone metabolic process GO:0010565 66 0.252
regulation of apoptotic signaling pathway GO:2001233 197 0.249
regulation of interleukin 13 secretion GO:2000665 2 0.245
response to organic cyclic compound GO:0014070 198 0.243
cellular response to lipopolysaccharide GO:0071222 77 0.237
response to hydrogen peroxide GO:0042542 32 0.236
interleukin 13 secretion GO:0072611 2 0.235
paracrine signaling GO:0038001 1 0.225
regulation of canonical wnt signaling pathway GO:0060828 82 0.222
single organismal cell cell adhesion GO:0016337 131 0.222
lipid oxidation GO:0034440 29 0.220
regulation of cell motility GO:2000145 236 0.216
negative regulation of protein phosphorylation GO:0001933 126 0.213
membrane organization GO:0061024 245 0.211
regionalization GO:0003002 337 0.203
response to inorganic substance GO:0010035 96 0.202
positive regulation of cell death GO:0010942 224 0.198
cellular response to oxidative stress GO:0034599 76 0.197
positive regulation of apoptotic process GO:0043065 217 0.196
terminal button organization GO:0072553 3 0.196
cellular ketone metabolic process GO:0042180 84 0.194
positive regulation of reactive oxygen species metabolic process GO:2000379 11 0.193
multicellular organism growth GO:0035264 161 0.188
brown fat cell differentiation GO:0050873 36 0.188
regulation of cellular response to stress GO:0080135 159 0.188
Fly
negative regulation of molecular function GO:0044092 258 0.186
monocarboxylic acid metabolic process GO:0032787 191 0.186
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.185
positive regulation of immature t cell proliferation GO:0033091 4 0.183
regulation of transferase activity GO:0051338 263 0.182
regulation of protein targeting GO:1903533 61 0.177
chemotaxis GO:0006935 247 0.176
negative regulation of protein metabolic process GO:0051248 282 0.172
lipid transport GO:0006869 98 0.171
regulation of syncytium formation by plasma membrane fusion GO:0060142 23 0.170
regulation of mapk cascade GO:0043408 248 0.168
Fly
action potential GO:0001508 78 0.166
cell cycle comprising mitosis without cytokinesis GO:0033301 1 0.165
regulation of cellular catabolic process GO:0031329 242 0.165
regulation of protein transport GO:0051223 163 0.164
nucleobase containing small molecule metabolic process GO:0055086 352 0.164
myeloid leukocyte differentiation GO:0002573 119 0.164
nucleoside phosphate catabolic process GO:1901292 222 0.164
muscle cell development GO:0055001 133 0.162
single organism cell adhesion GO:0098602 156 0.162
positive regulation of determination of dorsal identity GO:2000017 2 0.160
carbohydrate derivative catabolic process GO:1901136 231 0.160
cellular response to organonitrogen compound GO:0071417 145 0.158
reactive oxygen species metabolic process GO:0072593 84 0.155
defense response to bacterium GO:0042742 119 0.154
mitotic cell cycle GO:0000278 195 0.153
jun phosphorylation GO:0007258 41 0.151
regulation of response to oxidative stress GO:1902882 19 0.151
engulfment of apoptotic cell GO:0043652 3 0.148
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.147
interleukin 10 secretion GO:0072608 4 0.146
negative regulation of phosphate metabolic process GO:0045936 184 0.146
necrotic cell death GO:0070265 30 0.145
male gamete generation GO:0048232 285 0.144
circulatory system process GO:0003013 197 0.143
negative regulation of intracellular signal transduction GO:1902532 167 0.141
Mouse
immune response regulating signaling pathway GO:0002764 125 0.139
ribonucleotide catabolic process GO:0009261 208 0.139
regulation of dna dependent dna replication GO:0090329 8 0.137
protein autophosphorylation GO:0046777 61 0.137
regulation of intracellular transport GO:0032386 159 0.135
regulation of stress activated mapk cascade GO:0032872 69 0.134
Fly
positive regulation of myotube differentiation GO:0010831 24 0.133
protein ubiquitination GO:0016567 171 0.133
protein localization to membrane GO:0072657 108 0.132
protein localization to plasma membrane GO:0072659 57 0.132
cellular response to molecule of bacterial origin GO:0071219 83 0.132
syncytium formation by plasma membrane fusion GO:0000768 42 0.131
positive regulation of cellular amine metabolic process GO:0033240 5 0.131
regulation of determination of dorsal identity GO:2000015 3 0.127
response to peptide GO:1901652 136 0.126
regeneration GO:0031099 38 0.125
guanosine containing compound catabolic process GO:1901069 144 0.125
myotube differentiation GO:0014902 105 0.121
glucose homeostasis GO:0042593 128 0.120
defense response to gram positive bacterium GO:0050830 50 0.120
regulation of cellular response to oxidative stress GO:1900407 19 0.119
negative regulation of cellular amine metabolic process GO:0033239 1 0.119
regulation of cellular amino acid metabolic process GO:0006521 5 0.119
regulation of protein localization GO:0032880 231 0.118
epithelial cell morphogenesis GO:0003382 41 0.117
small gtpase mediated signal transduction GO:0007264 97 0.117
Mouse
muscle cell differentiation GO:0042692 261 0.116
aromatic compound catabolic process GO:0019439 286 0.116
muscle tissue development GO:0060537 308 0.116
cellular response to dna damage stimulus GO:0006974 207 0.115
Human
cellular response to peptide hormone stimulus GO:0071375 92 0.114
amine metabolic process GO:0009308 45 0.114
cytoplasmic transport GO:0016482 234 0.113
forebrain development GO:0030900 302 0.113
muscle fiber development GO:0048747 76 0.113
heterocycle catabolic process GO:0046700 280 0.111
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 68 0.111
myeloid cell differentiation GO:0030099 233 0.111
blood circulation GO:0008015 195 0.111
oocyte axis specification GO:0007309 2 0.109
neuronal action potential GO:0019228 54 0.106
t helper 2 cell activation GO:0035712 2 0.105
organ or tissue specific immune response GO:0002251 13 0.105
ribonucleoside triphosphate metabolic process GO:0009199 220 0.104
regulation of transcription from rna polymerase ii promoter in response to stress GO:0043618 8 0.104
cellular response to acid chemical GO:0071229 68 0.104
regulation of membrane potential GO:0042391 192 0.103
purine nucleoside triphosphate catabolic process GO:0009146 203 0.103
skeletal muscle fiber development GO:0048741 58 0.102
chondrocyte differentiation GO:0002062 72 0.102
cellular lipid metabolic process GO:0044255 323 0.102
cell adhesion GO:0007155 329 0.101
Fly
nucleoside metabolic process GO:0009116 246 0.101
generation of precursor metabolites and energy GO:0006091 103 0.100
peptidyl serine phosphorylation GO:0018105 74 0.100
Human
striated muscle cell development GO:0055002 125 0.099
protein targeting GO:0006605 143 0.097
cellular response to hormone stimulus GO:0032870 150 0.097
b cell proliferation GO:0042100 53 0.096
nucleoside triphosphate metabolic process GO:0009141 230 0.096
syncytium formation GO:0006949 43 0.095
innate immune response GO:0045087 157 0.094
fatty acid transmembrane transport GO:1902001 1 0.093
purine containing compound catabolic process GO:0072523 213 0.093
regulation of intracellular protein transport GO:0033157 82 0.093
lipid modification GO:0030258 65 0.092
regulation of interleukin 5 secretion GO:2000662 2 0.092
purine ribonucleotide metabolic process GO:0009150 290 0.092
cellular response to biotic stimulus GO:0071216 92 0.092
organophosphate catabolic process GO:0046434 232 0.091
myotube cell development GO:0014904 60 0.090
mitochondrion organization GO:0007005 134 0.089
regulation of leukocyte proliferation GO:0070663 121 0.089
cytokine production GO:0001816 319 0.088
positive regulation of growth GO:0045927 104 0.088
plasma membrane organization GO:0007009 90 0.087
gtp catabolic process GO:0006184 143 0.086
embryonic placenta development GO:0001892 98 0.085
osteoclast differentiation GO:0030316 62 0.084
regulation of myotube differentiation GO:0010830 62 0.084
cellular response to ionizing radiation GO:0071479 11 0.083
peptidyl amino acid modification GO:0018193 336 0.083
Human
positive regulation of apoptotic signaling pathway GO:2001235 95 0.083
ribonucleoside triphosphate catabolic process GO:0009203 199 0.083
positive regulation of fat cell differentiation GO:0045600 32 0.083
cellular response to inorganic substance GO:0071241 37 0.083
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.083
negative regulation of phagocytosis GO:0050765 4 0.083
nucleotide metabolic process GO:0009117 332 0.082
cellular response to carbohydrate stimulus GO:0071322 50 0.081
positive regulation of programmed cell death GO:0043068 218 0.081
regulation of fat cell differentiation GO:0045598 81 0.081
positive regulation of syncytium formation by plasma membrane fusion GO:0060143 17 0.080
regulation of cell adhesion GO:0030155 154 0.080
positive regulation of nucleocytoplasmic transport GO:0046824 30 0.080
endocytosis GO:0006897 168 0.079
defense response to other organism GO:0098542 197 0.079
fatty acid metabolic process GO:0006631 121 0.079
regulation of fatty acid beta oxidation GO:0031998 1 0.079
skeletal system morphogenesis GO:0048705 203 0.079
axon ensheathment GO:0008366 76 0.079
regulation of protein kinase activity GO:0045859 232 0.078
cartilage development GO:0051216 140 0.078
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.077
glucose metabolic process GO:0006006 92 0.077
cellular response to abiotic stimulus GO:0071214 56 0.075
camera type eye development GO:0043010 266 0.075
actin polymerization or depolymerization GO:0008154 54 0.074
heart contraction GO:0060047 93 0.074
canonical wnt signaling pathway GO:0060070 130 0.074
regulation of hormone levels GO:0010817 211 0.074
purine ribonucleotide catabolic process GO:0009154 208 0.073
keratinocyte development GO:0003334 10 0.073
regulation of body fluid levels GO:0050878 162 0.073
cell type specific apoptotic process GO:0097285 268 0.073
response to growth factor GO:0070848 198 0.073
Human
purine nucleotide catabolic process GO:0006195 211 0.073
regulation of actin filament based process GO:0032970 99 0.073
leukocyte differentiation GO:0002521 342 0.072
skin development GO:0043588 220 0.072
sensory organ morphogenesis GO:0090596 242 0.071
ensheathment of neurons GO:0007272 76 0.071
anion transport GO:0006820 177 0.071
regulation of protein serine threonine kinase activity GO:0071900 157 0.070
regulation of skeletal muscle fiber development GO:0048742 36 0.070
guanosine containing compound metabolic process GO:1901068 144 0.070
cellular response to peptide GO:1901653 92 0.069
jnk cascade GO:0007254 72 0.069
Fly
regulation of actin filament polymerization GO:0030833 38 0.069
plasma membrane long chain fatty acid transport GO:0015911 1 0.069
regulation of multi organism process GO:0043900 111 0.069
lipopolysaccharide mediated signaling pathway GO:0031663 25 0.068
positive regulation of protein targeting to membrane GO:0090314 7 0.068
purine nucleotide metabolic process GO:0006163 302 0.068
purine ribonucleoside metabolic process GO:0046128 241 0.068
positive regulation of transferase activity GO:0051347 167 0.068
actin filament organization GO:0007015 113 0.067
single organism nuclear import GO:1902593 95 0.067
monosaccharide metabolic process GO:0005996 106 0.067
regulation of myeloid cell differentiation GO:0045637 96 0.067
platelet activation GO:0030168 40 0.067
peptidyl tyrosine phosphorylation GO:0018108 143 0.067
activation of mapk activity involved in innate immune response GO:0035419 2 0.066
protein maturation GO:0051604 176 0.066
positive regulation of interleukin 5 secretion GO:2000664 1 0.065
purine nucleoside metabolic process GO:0042278 241 0.065
rho protein signal transduction GO:0007266 32 0.065
positive regulation of t helper 2 cell activation GO:2000570 2 0.064
protein polymerization GO:0051258 57 0.064
respiratory tube development GO:0030323 167 0.064
stress activated protein kinase signaling cascade GO:0031098 81 0.064
Fly
purine nucleoside catabolic process GO:0006152 205 0.063
positive regulation of glial cell proliferation GO:0060252 4 0.063
regulation of inflammatory response GO:0050727 147 0.063
nucleoside monophosphate metabolic process GO:0009123 85 0.062
establishment of protein localization to membrane GO:0090150 54 0.062
positive regulation of interleukin 10 secretion GO:2001181 1 0.061
purine nucleoside triphosphate metabolic process GO:0009144 226 0.060
reactive oxygen species biosynthetic process GO:1903409 8 0.060
circadian regulation of gene expression GO:0032922 48 0.059
hair follicle development GO:0001942 85 0.059
regulation of endocytosis GO:0030100 69 0.059
negative regulation of cellular protein metabolic process GO:0032269 247 0.059
connective tissue development GO:0061448 179 0.058
transforming growth factor beta receptor signaling pathway GO:0007179 71 0.058
ribonucleotide metabolic process GO:0009259 291 0.058
multicellular organismal signaling GO:0035637 91 0.058
blood vessel morphogenesis GO:0048514 285 0.058
angiogenesis GO:0001525 201 0.058
cellular carbohydrate metabolic process GO:0044262 119 0.058
cell aging GO:0007569 35 0.057
Mouse
cellular response to vascular endothelial growth factor stimulus GO:0035924 11 0.057
Human
regulation of establishment of protein localization GO:0070201 181 0.057
stress activated mapk cascade GO:0051403 80 0.057
Fly
regulation of map kinase activity GO:0043405 120 0.057
epithelial cell development GO:0002064 159 0.057
multi multicellular organism process GO:0044706 109 0.055
positive regulation of intracellular protein transport GO:0090316 42 0.055
adaptive immune response GO:0002250 155 0.055
t cell differentiation GO:0030217 174 0.055
negative regulation of kinase activity GO:0033673 81 0.055
regulation of cellular amine metabolic process GO:0033238 20 0.055
regulation of cellular component size GO:0032535 121 0.055
Fly
developmental growth involved in morphogenesis GO:0060560 138 0.054
regulation of cell projection assembly GO:0060491 38 0.054
response to alcohol GO:0097305 48 0.054
regulation of b cell proliferation GO:0030888 39 0.054
regulation of cell cycle process GO:0010564 160 0.053
negative regulation of filopodium assembly GO:0051490 2 0.053
cellular response to growth factor stimulus GO:0071363 197 0.053
Human
glial cell apoptotic process GO:0034349 3 0.053
regulation of t helper 2 cell cytokine production GO:2000551 3 0.053
positive regulation of cell projection organization GO:0031346 95 0.052
gtp metabolic process GO:0046039 144 0.052
regulation of ral gtpase activity GO:0032315 4 0.052
compound eye development GO:0048749 1 0.052
cellular protein complex assembly GO:0043623 116 0.052
positive regulation of organelle organization GO:0010638 128 0.052
regulation of erythrocyte differentiation GO:0045646 23 0.051
release of cytochrome c from mitochondria GO:0001836 23 0.051
establishment of organelle localization GO:0051656 122 0.051
protein localization to organelle GO:0033365 185 0.051
purine ribonucleoside catabolic process GO:0046130 205 0.051
regulation of lamellipodium assembly GO:0010591 3 0.051
forebrain cell migration GO:0021885 58 0.051
positive regulation of interleukin 13 secretion GO:2000667 1 0.050
establishment of protein localization to organelle GO:0072594 118 0.049
myeloid cell homeostasis GO:0002262 114 0.049
cellular response to insulin stimulus GO:0032869 78 0.049
labyrinthine layer blood vessel development GO:0060716 21 0.048
positive regulation of interleukin 13 production GO:0032736 4 0.048
positive regulation of intracellular transport GO:0032388 70 0.048
regulation of response to wounding GO:1903034 189 0.048
protein localization to nucleus GO:0034504 121 0.048
spermatid differentiation GO:0048515 115 0.048
positive regulation of peptidyl serine phosphorylation GO:0033138 25 0.048
lipid localization GO:0010876 126 0.047
negative regulation of protein modification process GO:0031400 163 0.047
rhythmic process GO:0048511 174 0.047
regulation of nucleotide catabolic process GO:0030811 122 0.047
nuclear dna replication GO:0033260 3 0.047
regulation of ras protein signal transduction GO:0046578 114 0.047
keratinocyte differentiation GO:0030216 48 0.047
purine containing compound metabolic process GO:0072521 311 0.047
positive regulation of protein transport GO:0051222 93 0.047
positive regulation of protein import into nucleus GO:0042307 26 0.047
cellularization GO:0007349 1 0.046
labyrinthine layer development GO:0060711 49 0.046
immune effector process GO:0002252 321 0.046
regulation of osteoblast differentiation GO:0045667 67 0.045
regulation of cytokine production GO:0001817 266 0.045
regulation of secretion GO:0051046 274 0.045
negative regulation of synapse assembly GO:0051964 3 0.045
substrate adhesion dependent cell spreading GO:0034446 30 0.045
regulation of secretion by cell GO:1903530 249 0.045
ribonucleoside metabolic process GO:0009119 245 0.044
response to extracellular stimulus GO:0009991 127 0.044
endothelium development GO:0003158 45 0.044
negative regulation of transferase activity GO:0051348 85 0.044
ribose phosphate metabolic process GO:0019693 291 0.044
positive regulation of myeloid cell differentiation GO:0045639 43 0.044
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.044
myosin filament assembly GO:0031034 2 0.043
spongiotrophoblast layer development GO:0060712 15 0.043
regulation of striated muscle cell differentiation GO:0051153 81 0.043
organic hydroxy compound metabolic process GO:1901615 203 0.043
nucleoside catabolic process GO:0009164 206 0.043
positive regulation of t cell activation GO:0050870 101 0.043
regulation of myoblast differentiation GO:0045661 29 0.043
circadian rhythm GO:0007623 114 0.043
regulation of lymphocyte activation GO:0051249 240 0.043
negative regulation of apoptotic signaling pathway GO:2001234 104 0.043
cellular amide metabolic process GO:0043603 58 0.043
response to endoplasmic reticulum stress GO:0034976 53 0.042
negative regulation of cellular response to insulin stimulus GO:1900077 16 0.042
organic anion transport GO:0015711 137 0.042
nuclear import GO:0051170 95 0.042
regulation of protein import into nucleus GO:0042306 52 0.042
glycoprotein metabolic process GO:0009100 116 0.041
regulation of myeloid leukocyte differentiation GO:0002761 58 0.041
regulation of system process GO:0044057 200 0.041
regulation of lipid transport GO:0032368 36 0.041
regulation of cell size GO:0008361 72 0.041
Fly
establishment or maintenance of microtubule cytoskeleton polarity GO:0030951 1 0.041
establishment of vesicle localization GO:0051650 81 0.041
mucosal immune response GO:0002385 13 0.041
cytokine metabolic process GO:0042107 71 0.041
positive regulation of vesicle fusion GO:0031340 2 0.041
positive regulation of lymphocyte mediated immunity GO:0002708 62 0.041
ral protein signal transduction GO:0032484 2 0.040
actin filament polymerization GO:0030041 44 0.040
negative regulation of phosphorus metabolic process GO:0010563 184 0.040
regulation of organ morphogenesis GO:2000027 144 0.040
positive regulation of lipid metabolic process GO:0045834 40 0.040
coagulation GO:0050817 78 0.040
positive regulation of cellular catabolic process GO:0031331 148 0.039
glycosyl compound catabolic process GO:1901658 206 0.039
response to ischemia GO:0002931 14 0.039
epidermis development GO:0008544 187 0.038
oocyte anterior posterior axis specification GO:0007314 2 0.038
organelle fission GO:0048285 170 0.038
t helper 2 cell cytokine production GO:0035745 4 0.038
establishment of protein localization to plasma membrane GO:0090002 34 0.038
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.038
t cell activation GO:0042110 289 0.038
regulation of reactive oxygen species biosynthetic process GO:1903426 2 0.038
positive regulation of cytoplasmic transport GO:1903651 40 0.037
immune response activating signal transduction GO:0002757 116 0.037
regulation of cell cycle GO:0051726 281 0.037
leukocyte mediated immunity GO:0002443 174 0.037
positive regulation of ion transport GO:0043270 65 0.037
regulation of cytoplasmic transport GO:1903649 112 0.037
regulation of lymphocyte differentiation GO:0045619 107 0.036
regulation of vesicle mediated transport GO:0060627 139 0.036
positive regulation of cytokine production GO:0001819 174 0.036
dna metabolic process GO:0006259 303 0.036
regulation of glucose metabolic process GO:0010906 60 0.036
positive regulation of gtpase activity GO:0043547 85 0.036
response to light stimulus GO:0009416 135 0.036
alpha beta t cell differentiation GO:0046632 69 0.036
stress induced premature senescence GO:0090400 2 0.036
Mouse
positive regulation of actin filament polymerization GO:0030838 26 0.035
dorsal ventral axon guidance GO:0033563 3 0.035
skeletal muscle tissue regeneration GO:0043403 20 0.035
glycosyl compound metabolic process GO:1901657 246 0.035
regulation of reactive oxygen species metabolic process GO:2000377 40 0.035
regulation of purine nucleotide catabolic process GO:0033121 122 0.035
negative regulation of immune system process GO:0002683 209 0.035
cell fate commitment GO:0045165 210 0.035
receptor mediated endocytosis GO:0006898 51 0.035
locomotory behavior GO:0007626 195 0.035
negative regulation of map kinase activity GO:0043407 34 0.035
cellular response to epidermal growth factor stimulus GO:0071364 4 0.034
regulation of tight junction assembly GO:2000810 2 0.034
negative regulation of neuron apoptotic process GO:0043524 92 0.034
regulation of neuron projection development GO:0010975 169 0.034
positive regulation of kinase activity GO:0033674 155 0.034
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.034
Human
regulation of muscle tissue development GO:1901861 97 0.034
apoptotic mitochondrial changes GO:0008637 48 0.034
nucleocytoplasmic transport GO:0006913 139 0.034
dephosphorylation GO:0016311 129 0.033
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.033
determination of dorsal identity GO:0048263 5 0.033
striated muscle myosin thick filament assembly GO:0071688 1 0.033
cd4 positive alpha beta t cell cytokine production GO:0035743 4 0.033
cellular response to granulocyte macrophage colony stimulating factor stimulus GO:0097011 3 0.033
cell substrate adhesion GO:0031589 130 0.033
mitotic cell cycle process GO:1903047 159 0.033
regulation of type 2 immune response GO:0002828 18 0.033
positive regulation of cell migration GO:0030335 109 0.033
hexose metabolic process GO:0019318 98 0.033
filopodium assembly GO:0046847 19 0.033
lung development GO:0030324 164 0.032
cellular nitrogen compound catabolic process GO:0044270 280 0.032
epithelial tube morphogenesis GO:0060562 303 0.032
positive regulation of protein localization to nucleus GO:1900182 30 0.032
skeletal system development GO:0001501 356 0.032
i kappab kinase nf kappab signaling GO:0007249 85 0.032
neuron projection regeneration GO:0031102 14 0.032
positive regulation of t helper 2 cell cytokine production GO:2000553 3 0.032
embryonic olfactory bulb interneuron precursor migration GO:0021831 2 0.032
carbohydrate derivative biosynthetic process GO:1901137 183 0.031
ameboidal type cell migration GO:0001667 128 0.031
regulation of ral protein signal transduction GO:0032485 4 0.031
synaptic transmission GO:0007268 329 0.031
regulation of protein catabolic process GO:0042176 108 0.031
respiratory system development GO:0060541 190 0.031
positive regulation of catecholamine secretion GO:0033605 2 0.031
positive regulation of neuron projection regeneration GO:0070572 2 0.031
regulation of interleukin 2 biosynthetic process GO:0045076 13 0.031
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.031
glial cell differentiation GO:0010001 131 0.030
positive regulation of cell motility GO:2000147 116 0.030
negative regulation of interleukin 5 secretion GO:2000663 1 0.030
regulation of actin cytoskeleton organization GO:0032956 84 0.030
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 87 0.030
positive regulation of leukocyte proliferation GO:0070665 73 0.030
regulation of nucleoside metabolic process GO:0009118 130 0.030
regulation of hydrolase activity GO:0051336 246 0.030
regulation of peptidyl serine phosphorylation GO:0033135 39 0.030
sulfur compound metabolic process GO:0006790 100 0.030
establishment of planar polarity GO:0001736 28 0.030
humoral immune response GO:0006959 57 0.030
ear morphogenesis GO:0042471 118 0.030
negative regulation of wnt signaling pathway GO:0030178 73 0.030
regulation of dna templated transcription in response to stress GO:0043620 9 0.030
positive regulation of lymphocyte activation GO:0051251 140 0.030

Mapkapk2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
myopathy DOID:423 0 0.055
muscular disease DOID:0080000 0 0.055
heart disease DOID:114 0 0.055
cardiomyopathy DOID:0050700 0 0.055
disease of anatomical entity DOID:7 0 0.055
intrinsic cardiomyopathy DOID:0060036 0 0.055
cardiovascular system disease DOID:1287 0 0.055
musculoskeletal system disease DOID:17 0 0.055
muscle tissue disease DOID:66 0 0.055
cancer DOID:162 0 0.039
disease of cellular proliferation DOID:14566 0 0.039