Mus musculus

27 known processes

Mcm6

minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae)

(Aliases: Mcmd6,D1Wsu22e,ASP-l1)

Mcm6 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
protein dna complex subunit organization GO:0071824 28 0.560
Yeast
cellular response to dna damage stimulus GO:0006974 207 0.422
Yeast
dna metabolic process GO:0006259 303 0.363
nucleoside monophosphate metabolic process GO:0009123 85 0.344
Human Yeast
organelle fission GO:0048285 170 0.317
microtubule cytoskeleton organization GO:0000226 157 0.284
chromosome separation GO:0051304 14 0.274
dna repair GO:0006281 107 0.249
Yeast
double strand break repair GO:0006302 48 0.225
Yeast
nuclear division GO:0000280 158 0.196
dna endoreduplication GO:0042023 4 0.195
nuclear dna replication GO:0033260 3 0.190
Yeast
nucleoside triphosphate metabolic process GO:0009141 230 0.179
Human Yeast
chromatin organization GO:0006325 206 0.157
nucleobase containing small molecule metabolic process GO:0055086 352 0.156
Human Yeast
negative regulation of chromatin silencing GO:0031936 1 0.155
mitotic cell cycle GO:0000278 195 0.155
regulation of transcription by chromatin organization GO:0034401 0 0.150
purine ribonucleotide metabolic process GO:0009150 290 0.143
Human Yeast
purine nucleoside triphosphate metabolic process GO:0009144 226 0.141
Human Yeast
nucleotide metabolic process GO:0009117 332 0.139
Human Yeast
chromosome segregation GO:0007059 48 0.134
chromatin silencing GO:0006342 15 0.127
meiotic nuclear division GO:0007126 115 0.124
purine ribonucleoside metabolic process GO:0046128 241 0.121
Human Yeast
purine nucleoside monophosphate catabolic process GO:0009128 58 0.119
Human Yeast
regulation of cell cycle GO:0051726 281 0.116
deoxyribonucleotide biosynthetic process GO:0009263 6 0.114
mitotic cell cycle process GO:1903047 159 0.100
regulation of dna dependent dna replication initiation GO:0030174 3 0.098
cellular amino acid metabolic process GO:0006520 103 0.094
ribonucleoside triphosphate catabolic process GO:0009203 199 0.091
Human Yeast
organic cyclic compound catabolic process GO:1901361 295 0.090
Human Yeast
aromatic compound catabolic process GO:0019439 286 0.089
Human Yeast
purine containing compound metabolic process GO:0072521 311 0.088
Human Yeast
protein heterotetramerization GO:0051290 4 0.087
nucleotide catabolic process GO:0009166 217 0.086
Human Yeast
meiotic cell cycle GO:0051321 122 0.084
purine nucleoside metabolic process GO:0042278 241 0.081
Human Yeast
nucleoside phosphate catabolic process GO:1901292 222 0.080
Human Yeast
regulation of cell cycle process GO:0010564 160 0.080
ribonucleoside catabolic process GO:0042454 206 0.079
Human Yeast
purine ribonucleoside monophosphate catabolic process GO:0009169 57 0.078
Human Yeast
response to ionizing radiation GO:0010212 42 0.077
dna geometric change GO:0032392 7 0.076
cellular macromolecule catabolic process GO:0044265 206 0.075
nucleoside catabolic process GO:0009164 206 0.073
Human Yeast
microtubule based process GO:0007017 236 0.071
dna recombination GO:0006310 92 0.070
Yeast
regulation of hydrolase activity GO:0051336 246 0.069
glycosyl compound catabolic process GO:1901658 206 0.066
Human Yeast
glycosyl compound metabolic process GO:1901657 246 0.065
Human Yeast
deoxyribonucleotide metabolic process GO:0009262 14 0.065
glial cell differentiation GO:0010001 131 0.065
nucleoside phosphate biosynthetic process GO:1901293 79 0.065
purine nucleoside monophosphate metabolic process GO:0009126 81 0.063
Human Yeast
humoral immune response GO:0006959 57 0.062
purine nucleotide metabolic process GO:0006163 302 0.062
Human Yeast
cellular protein catabolic process GO:0044257 155 0.062
mitotic sister chromatid separation GO:0051306 9 0.061
sister chromatid segregation GO:0000819 20 0.060
apoptotic signaling pathway GO:0097190 306 0.060
ribonucleoside monophosphate metabolic process GO:0009161 80 0.058
Human Yeast
organophosphate biosynthetic process GO:0090407 122 0.057
nucleoside metabolic process GO:0009116 246 0.057
Human Yeast
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.057
Human Yeast
nucleotide biosynthetic process GO:0009165 78 0.057
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.056
Human Yeast
ribonucleotide metabolic process GO:0009259 291 0.056
Human Yeast
intrinsic apoptotic signaling pathway GO:0097193 132 0.056
purine containing compound catabolic process GO:0072523 213 0.056
Human Yeast
glial cell development GO:0021782 54 0.056
purine nucleoside triphosphate catabolic process GO:0009146 203 0.055
Human Yeast
response to inorganic substance GO:0010035 96 0.054
nucleoside phosphate metabolic process GO:0006753 338 0.054
Human Yeast
dna unwinding involved in dna replication GO:0006268 5 0.053
purine nucleotide catabolic process GO:0006195 211 0.053
Human Yeast
purine ribonucleotide catabolic process GO:0009154 208 0.051
Human Yeast
nucleoside triphosphate catabolic process GO:0009143 205 0.050
Human Yeast
carbohydrate derivative catabolic process GO:1901136 231 0.049
Human Yeast
ribonucleotide catabolic process GO:0009261 208 0.049
Human Yeast
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.048
Human Yeast
gene silencing GO:0016458 38 0.048
oxidation reduction process GO:0055114 342 0.047
ribonucleoside metabolic process GO:0009119 245 0.046
Human Yeast
regulation of mitotic cell cycle phase transition GO:1901990 73 0.046
engulfment of apoptotic cell GO:0043652 3 0.046
double strand break repair via homologous recombination GO:0000724 21 0.045
Yeast
developmental cell growth GO:0048588 84 0.044
dna dependent dna replication GO:0006261 24 0.044
negative regulation of mitotic cell cycle phase transition GO:1901991 45 0.044
intracellular mrna localization GO:0008298 4 0.044
cellular response to growth factor stimulus GO:0071363 197 0.043
negative regulation of nucleoside metabolic process GO:0045978 11 0.043
regulation of cellular catabolic process GO:0031329 242 0.043
negative regulation of gene silencing GO:0060969 2 0.042
ribose phosphate metabolic process GO:0019693 291 0.041
Human Yeast
heterocycle catabolic process GO:0046700 280 0.039
Human Yeast
histone lysine methylation GO:0034968 50 0.039
methylation GO:0032259 134 0.039
carbohydrate derivative biosynthetic process GO:1901137 183 0.038
protein maturation GO:0051604 176 0.037
endocytosis GO:0006897 168 0.037
response to testosterone GO:0033574 3 0.037
histone methylation GO:0016571 71 0.036
blood circulation GO:0008015 195 0.036
cellular ketone metabolic process GO:0042180 84 0.036
mitotic sister chromatid segregation GO:0000070 14 0.036
organophosphate catabolic process GO:0046434 232 0.036
Human Yeast
dna replication GO:0006260 52 0.035
organonitrogen compound biosynthetic process GO:1901566 192 0.035
atp catabolic process GO:0006200 55 0.035
Human Yeast
heterochromatin organization GO:0070828 4 0.035
atp metabolic process GO:0046034 75 0.034
Human Yeast
ras protein signal transduction GO:0007265 77 0.034
purine nucleoside catabolic process GO:0006152 205 0.034
Human Yeast
membrane organization GO:0061024 245 0.034
purine ribonucleoside catabolic process GO:0046130 205 0.034
Human Yeast
chromatin modification GO:0016568 187 0.033
male gamete generation GO:0048232 285 0.033
camera type eye development GO:0043010 266 0.033
chromatin assembly GO:0031497 13 0.032
alpha amino acid metabolic process GO:1901605 59 0.032
gliogenesis GO:0042063 141 0.032
g1 s transition of mitotic cell cycle GO:0000082 57 0.032
response to organic cyclic compound GO:0014070 198 0.032
protein processing GO:0016485 163 0.030
response to organonitrogen compound GO:0010243 246 0.029
cell growth GO:0016049 130 0.028
dna replication initiation GO:0006270 5 0.028
Yeast
cell cycle checkpoint GO:0000075 47 0.028
inner cell mass cell proliferation GO:0001833 15 0.028
response to metal ion GO:0010038 47 0.028
monocarboxylic acid metabolic process GO:0032787 191 0.028
multicellular organismal aging GO:0010259 24 0.027
regulation of response to wounding GO:1903034 189 0.027
regulation of cellular amino acid metabolic process GO:0006521 5 0.027
mrna splicing via spliceosome GO:0000398 43 0.027
positive regulation of apoptotic process GO:0043065 217 0.027
cell cycle g1 s phase transition GO:0044843 57 0.027
negative regulation of atpase activity GO:0032780 2 0.027
regulation of purine nucleotide metabolic process GO:1900542 169 0.027
cofactor metabolic process GO:0051186 80 0.026
purine nucleobase biosynthetic process GO:0009113 3 0.025
nucleoside monophosphate catabolic process GO:0009125 59 0.025
Human Yeast
response to growth factor GO:0070848 198 0.025
mitotic nuclear division GO:0007067 48 0.024
response to light stimulus GO:0009416 135 0.024
ubiquitin dependent protein catabolic process GO:0006511 129 0.024
rhythmic process GO:0048511 174 0.024
leukocyte activation involved in immune response GO:0002366 126 0.024
protein methylation GO:0006479 81 0.023
cellular response to abiotic stimulus GO:0071214 56 0.023
spermatogenesis GO:0007283 284 0.023
neural precursor cell proliferation GO:0061351 121 0.023
regulation of defense response GO:0031347 233 0.023
cell adhesion GO:0007155 329 0.023
regulation of neuron projection development GO:0010975 169 0.022
positive regulation of programmed cell death GO:0043068 218 0.022
response to radiation GO:0009314 165 0.022
dna dependent dna replication maintenance of fidelity GO:0045005 3 0.022
germ cell development GO:0007281 185 0.021
Worm Fly
response to oxidative stress GO:0006979 123 0.021
circulatory system process GO:0003013 197 0.021
regulation of protein catabolic process GO:0042176 108 0.020
intrahepatic bile duct development GO:0035622 2 0.020
amine metabolic process GO:0009308 45 0.020
histone modification GO:0016570 159 0.020
gonad development GO:0008406 141 0.020
Worm
positive regulation of protein phosphorylation GO:0001934 242 0.020
translesion synthesis GO:0019985 1 0.019
sulfur compound metabolic process GO:0006790 100 0.019
double strand break repair via nonhomologous end joining GO:0006303 10 0.019
production of molecular mediator of immune response GO:0002440 103 0.019
regulation of cell cycle phase transition GO:1901987 77 0.019
recombinational repair GO:0000725 21 0.018
Yeast
regulation of atp metabolic process GO:1903578 17 0.018
sensory organ morphogenesis GO:0090596 242 0.018
leukocyte migration GO:0050900 124 0.017
negative regulation of molecular function GO:0044092 258 0.017
myeloid cell differentiation GO:0030099 233 0.017
positive regulation of cellular amine metabolic process GO:0033240 5 0.017
ribonucleoside triphosphate metabolic process GO:0009199 220 0.016
Human Yeast
inflammatory response GO:0006954 244 0.016
heart contraction GO:0060047 93 0.016
coenzyme metabolic process GO:0006732 52 0.016
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 57 0.016
nitrogen compound transport GO:0071705 271 0.016
gland development GO:0048732 330 0.016
regulation of cellular ketone metabolic process GO:0010565 66 0.016
cell type specific apoptotic process GO:0097285 268 0.016
uronic acid metabolic process GO:0006063 2 0.016
positive regulation of intracellular transport GO:0032388 70 0.016
neuron death GO:0070997 154 0.016
regulation of mitotic cell cycle GO:0007346 126 0.015
rna splicing GO:0008380 54 0.015
development of primary sexual characteristics GO:0045137 143 0.015
Worm
organonitrogen compound catabolic process GO:1901565 264 0.015
Human Yeast
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.015
meiotic cell cycle process GO:1903046 77 0.015
cellular homeostasis GO:0019725 240 0.015
regulation of nucleotide metabolic process GO:0006140 169 0.015
regulation of heart contraction GO:0008016 77 0.015
macromolecule methylation GO:0043414 120 0.015
positive regulation of protein modification process GO:0031401 299 0.015
positive regulation of cellular catabolic process GO:0031331 148 0.015
blastocyst development GO:0001824 80 0.014
lymphocyte mediated immunity GO:0002449 139 0.014
female gamete generation GO:0007292 74 0.014
Worm Fly
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.014
organism emergence from protective structure GO:0071684 4 0.014
maturation of 5 8s rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna GO:0000466 1 0.014
skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration GO:0014834 3 0.014
protein localization to organelle GO:0033365 185 0.014
cellular amine metabolic process GO:0044106 44 0.014
regulation of neuron apoptotic process GO:0043523 122 0.014
cellular response to cytokine stimulus GO:0071345 189 0.014
maintenance of location GO:0051235 89 0.014
oocyte anterior posterior axis specification GO:0007314 2 0.014
ribonucleoside monophosphate catabolic process GO:0009158 57 0.013
Human Yeast
folic acid containing compound metabolic process GO:0006760 3 0.013
maternal process involved in female pregnancy GO:0060135 32 0.013
cell division GO:0051301 120 0.013
regulation of organelle organization GO:0033043 289 0.013
cell maturation GO:0048469 127 0.013
genitalia development GO:0048806 37 0.013
Worm
positive regulation of cell death GO:0010942 224 0.013
blastocyst growth GO:0001832 23 0.013
negative regulation of cellular protein metabolic process GO:0032269 247 0.013
sister chromatid cohesion GO:0007062 12 0.013
regulation of cellular amine metabolic process GO:0033238 20 0.013
response to uv GO:0009411 44 0.013
negative regulation of gene expression epigenetic GO:0045814 15 0.013
regulation of inflammatory response GO:0050727 147 0.013
hatching GO:0035188 4 0.013
positive regulation of chromosome organization GO:2001252 33 0.013
liver development GO:0001889 66 0.013
hepaticobiliary system development GO:0061008 67 0.013
somatic recombination of immunoglobulin gene segments GO:0016447 42 0.012
cellular protein complex assembly GO:0043623 116 0.012
regulation of cell size GO:0008361 72 0.012
regulation of proteolysis GO:0030162 164 0.012
positive regulation of neuron differentiation GO:0045666 141 0.012
regulation of embryonic development GO:0045995 71 0.012
placenta development GO:0001890 140 0.012
rna processing GO:0006396 105 0.012
cell fate commitment GO:0045165 210 0.012
Fly
translation GO:0006412 93 0.012
immunoglobulin production GO:0002377 73 0.012
asymmetric stem cell division GO:0098722 3 0.012
ossification GO:0001503 216 0.012
regulation of intracellular transport GO:0032386 159 0.012
regulation of cysteine type endopeptidase activity GO:2000116 65 0.012
protein oligomerization GO:0051259 67 0.012
cellular lipid metabolic process GO:0044255 323 0.011
pancreas development GO:0031016 57 0.011
reciprocal dna recombination GO:0035825 16 0.011
regulation of membrane potential GO:0042391 192 0.011
protein alkylation GO:0008213 81 0.011
covalent chromatin modification GO:0016569 163 0.011
single organism cell adhesion GO:0098602 156 0.011
regulation of cytoplasmic transport GO:1903649 112 0.011
antimicrobial peptide biosynthetic process GO:0002777 2 0.011
response to alcohol GO:0097305 48 0.011
regulation of lymphocyte activation GO:0051249 240 0.011
ion transmembrane transport GO:0034220 361 0.011
response to acid chemical GO:0001101 111 0.011
receptor mediated endocytosis GO:0006898 51 0.011
multi multicellular organism process GO:0044706 109 0.011
proteasomal protein catabolic process GO:0010498 98 0.011
microtubule organizing center organization GO:0031023 28 0.011
neuron apoptotic process GO:0051402 142 0.011
transmembrane transport GO:0055085 412 0.011
regulation of blood circulation GO:1903522 93 0.011
organic anion transport GO:0015711 137 0.011
maternal placenta development GO:0001893 20 0.011
ovulation GO:0030728 15 0.011
carbohydrate homeostasis GO:0033500 128 0.011
positive regulation of cell cycle phase transition GO:1901989 17 0.011
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 62 0.011
cell activation involved in immune response GO:0002263 126 0.011
response to temperature stimulus GO:0009266 55 0.011
b cell activation involved in immune response GO:0002312 50 0.011
negative regulation of cell cycle GO:0045786 123 0.011
regulation of cell projection organization GO:0031344 206 0.011
rna catabolic process GO:0006401 29 0.011
positive regulation of histone modification GO:0031058 28 0.010
heart morphogenesis GO:0003007 178 0.010
connective tissue development GO:0061448 179 0.010
regulation of rna splicing GO:0043484 37 0.010
negative regulation of intracellular signal transduction GO:1902532 167 0.010
regulation of protein transport GO:0051223 163 0.010
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.010
positive regulation of organelle organization GO:0010638 128 0.010
regulation of cell migration GO:0030334 219 0.010

Mcm6 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 0 0.223
cancer DOID:162 0 0.097
organ system cancer DOID:0050686 0 0.056
gastrointestinal system cancer DOID:3119 0 0.043
disease of anatomical entity DOID:7 0 0.020
nervous system disease DOID:863 0 0.020
large intestine cancer DOID:5672 0 0.020
intestinal cancer DOID:10155 0 0.020
breast cancer DOID:1612 0 0.013
thoracic cancer DOID:5093 0 0.013