Mus musculus

5 known processes

Mdh2

malate dehydrogenase 2, NAD (mitochondrial)

(Aliases: MDH,Mor1,Mdh-2,Mor-1)

Mdh2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
citrate metabolic process GO:0006101 3 0.989
oxidation reduction process GO:0055114 342 0.943
nadh metabolic process GO:0006734 1 0.916
atp metabolic process GO:0046034 75 0.872
generation of precursor metabolites and energy GO:0006091 103 0.861
Fly
cellular respiration GO:0045333 38 0.849
Fly
energy derivation by oxidation of organic compounds GO:0015980 77 0.789
Fly
nucleoside triphosphate metabolic process GO:0009141 230 0.779
nucleoside phosphate metabolic process GO:0006753 338 0.765
nucleotide metabolic process GO:0009117 332 0.673
tricarboxylic acid metabolic process GO:0072350 5 0.589
intrinsic apoptotic signaling pathway GO:0097193 132 0.583
purine nucleoside triphosphate metabolic process GO:0009144 226 0.517
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.396
nucleoside monophosphate metabolic process GO:0009123 85 0.396
glycosyl compound metabolic process GO:1901657 246 0.395
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.364
purine containing compound metabolic process GO:0072521 311 0.357
purine ribonucleotide metabolic process GO:0009150 290 0.356
nucleobase containing small molecule metabolic process GO:0055086 352 0.342
ribonucleoside metabolic process GO:0009119 245 0.328
purine nucleoside monophosphate metabolic process GO:0009126 81 0.328
purine nucleotide metabolic process GO:0006163 302 0.321
coenzyme metabolic process GO:0006732 52 0.318
purine nucleoside metabolic process GO:0042278 241 0.297
nucleoside metabolic process GO:0009116 246 0.257
ribonucleotide metabolic process GO:0009259 291 0.244
hydrogen ion transmembrane transport GO:1902600 25 0.244
oxidative phosphorylation GO:0006119 14 0.238
oxidoreduction coenzyme metabolic process GO:0006733 16 0.228
purine ribonucleoside metabolic process GO:0046128 241 0.202
ion transmembrane transport GO:0034220 361 0.186
ribose phosphate metabolic process GO:0019693 291 0.184
multicellular organismal aging GO:0010259 24 0.171
ribonucleoside triphosphate metabolic process GO:0009199 220 0.167
carbohydrate derivative biosynthetic process GO:1901137 183 0.165
nad metabolic process GO:0019674 7 0.137
transmembrane transport GO:0055085 412 0.136
atp synthesis coupled electron transport GO:0042773 8 0.136
regulation of intrinsic apoptotic signaling pathway GO:2001242 61 0.111
cation transport GO:0006812 399 0.103
nucleoside phosphate biosynthetic process GO:1901293 79 0.097
monocarboxylic acid metabolic process GO:0032787 191 0.097
ribonucleoside monophosphate metabolic process GO:0009161 80 0.095
inorganic ion transmembrane transport GO:0098660 234 0.094
glycolytic process GO:0006096 20 0.093
mitochondrial electron transport ubiquinol to cytochrome c GO:0006122 2 0.091
hydrogen transport GO:0006818 35 0.077
apoptotic signaling pathway GO:0097190 306 0.074
coenzyme biosynthetic process GO:0009108 23 0.074
heterocycle catabolic process GO:0046700 280 0.073
determination of adult lifespan GO:0008340 11 0.072
inorganic cation transmembrane transport GO:0098662 207 0.068
cation transmembrane transport GO:0098655 266 0.062
purine ribonucleoside biosynthetic process GO:0046129 19 0.062
organophosphate biosynthetic process GO:0090407 122 0.061
anatomical structure homeostasis GO:0060249 145 0.060
purine ribonucleotide biosynthetic process GO:0009152 59 0.056
purine nucleoside triphosphate catabolic process GO:0009146 203 0.056
aromatic compound catabolic process GO:0019439 286 0.055
aerobic respiration GO:0009060 7 0.054
Fly
carbohydrate catabolic process GO:0016052 32 0.053
carbohydrate metabolic process GO:0005975 230 0.053
endocytosis GO:0006897 168 0.052
proton transport GO:0015992 35 0.052
purine nucleoside monophosphate biosynthetic process GO:0009127 9 0.050
metal ion homeostasis GO:0055065 189 0.049
carbohydrate derivative catabolic process GO:1901136 231 0.047
ribonucleoside monophosphate biosynthetic process GO:0009156 9 0.046
purine nucleotide biosynthetic process GO:0006164 65 0.046
cellular ketone metabolic process GO:0042180 84 0.046
negative regulation of cell proliferation GO:0008285 296 0.045
spermatogenesis GO:0007283 284 0.041
cofactor transport GO:0051181 4 0.040
cellular ion homeostasis GO:0006873 165 0.040
heme transport GO:0015886 2 0.039
gonad development GO:0008406 141 0.038
atp catabolic process GO:0006200 55 0.037
positive regulation of intrinsic apoptotic signaling pathway GO:2001244 25 0.036
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.036
synaptic transmission GO:0007268 329 0.035
regulation of apoptotic signaling pathway GO:2001233 197 0.035
purine nucleoside biosynthetic process GO:0042451 19 0.035
regulation of nucleotide metabolic process GO:0006140 169 0.035
anion transport GO:0006820 177 0.034
nucleotide catabolic process GO:0009166 217 0.034
glycosyl compound catabolic process GO:1901658 206 0.033
succinyl coa metabolic process GO:0006104 1 0.033
development of primary sexual characteristics GO:0045137 143 0.033
positive regulation of proteolysis GO:0045862 85 0.032
Fly
cofactor metabolic process GO:0051186 80 0.032
epithelial cell proliferation GO:0050673 174 0.032
reactive oxygen species metabolic process GO:0072593 84 0.031
neurotransmitter transport GO:0006836 76 0.031
monosaccharide metabolic process GO:0005996 106 0.031
cellular macromolecule catabolic process GO:0044265 206 0.030
purine containing compound catabolic process GO:0072523 213 0.030
cellular lipid metabolic process GO:0044255 323 0.030
nicotinamide nucleotide metabolic process GO:0046496 12 0.030
regulation of epithelial cell proliferation GO:0050678 141 0.029
muscle system process GO:0003012 141 0.029
mitochondrial atp synthesis coupled electron transport GO:0042775 8 0.029
nitrogen compound transport GO:0071705 271 0.029
ribose phosphate biosynthetic process GO:0046390 59 0.028
nucleoside triphosphate catabolic process GO:0009143 205 0.028
positive regulation of cell death GO:0010942 224 0.028
Fly
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.026
pyridine nucleotide metabolic process GO:0019362 12 0.025
regulation of atp metabolic process GO:1903578 17 0.025
negative regulation of intrinsic apoptotic signaling pathway GO:2001243 34 0.025
regulation of ion transport GO:0043269 215 0.025
purine nucleoside triphosphate biosynthetic process GO:0009145 7 0.025
nucleoside catabolic process GO:0009164 206 0.024
substantia nigra development GO:0021762 2 0.024
regulation of atp biosynthetic process GO:2001169 3 0.024
regulation of purine nucleotide metabolic process GO:1900542 169 0.024
positive regulation of apoptotic process GO:0043065 217 0.023
Fly
nucleotide biosynthetic process GO:0009165 78 0.023
macromolecule catabolic process GO:0009057 281 0.022
endothelial cell proliferation GO:0001935 27 0.022
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 36 0.022
Fly
regulation of oxidative phosphorylation uncoupler activity GO:2000275 3 0.021
positive regulation of hydrolase activity GO:0051345 148 0.021
Fly
regulation of proteolysis GO:0030162 164 0.021
Fly
response to oxygen levels GO:0070482 62 0.021
cellular homeostasis GO:0019725 240 0.021
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.021
regulation of cellular amino acid metabolic process GO:0006521 5 0.021
locomotory behavior GO:0007626 195 0.020
morphogenesis of a branching epithelium GO:0061138 193 0.020
neural tube formation GO:0001841 108 0.020
purine ribonucleotide catabolic process GO:0009154 208 0.020
cation homeostasis GO:0055080 212 0.020
aldehyde catabolic process GO:0046185 4 0.020
cytoplasmic transport GO:0016482 234 0.019
positive regulation of growth GO:0045927 104 0.019
cellular amine metabolic process GO:0044106 44 0.019
regulation of lymphocyte activation GO:0051249 240 0.019
cellular amino acid metabolic process GO:0006520 103 0.019
lactate biosynthetic process GO:0019249 4 0.019
genitalia development GO:0048806 37 0.018
organic anion transport GO:0015711 137 0.018
regulation of neurotransmitter levels GO:0001505 87 0.018
ribonucleoside catabolic process GO:0042454 206 0.018
action potential GO:0001508 78 0.018
purine ribonucleoside triphosphate biosynthetic process GO:0009206 6 0.018
epithelial tube morphogenesis GO:0060562 303 0.018
positive regulation of apoptotic signaling pathway GO:2001235 95 0.018
regulation of nucleoside metabolic process GO:0009118 130 0.018
myosin filament organization GO:0031033 3 0.018
positive regulation of cellular amine metabolic process GO:0033240 5 0.018
regulation of cell activation GO:0050865 289 0.018
regulation of membrane potential GO:0042391 192 0.018
cell growth GO:0016049 130 0.018
blood vessel morphogenesis GO:0048514 285 0.018
ribonucleoside monophosphate catabolic process GO:0009158 57 0.017
purine nucleoside catabolic process GO:0006152 205 0.017
adult locomotory behavior GO:0008344 91 0.017
organelle localization GO:0051640 179 0.016
organic acid transport GO:0015849 101 0.016
regulation of organelle organization GO:0033043 289 0.016
adult behavior GO:0030534 135 0.016
protein catabolic process GO:0030163 221 0.016
response to organonitrogen compound GO:0010243 246 0.016
negative regulation of growth GO:0045926 99 0.016
response to radiation GO:0009314 165 0.016
regulation of cellular amine metabolic process GO:0033238 20 0.016
cellular metal ion homeostasis GO:0006875 151 0.015
pentose phosphate shunt GO:0006098 2 0.015
pyridine containing compound metabolic process GO:0072524 14 0.015
organonitrogen compound biosynthetic process GO:1901566 192 0.015
glycosyl compound biosynthetic process GO:1901659 21 0.015
nucleoside phosphate catabolic process GO:1901292 222 0.015
purine ribonucleoside monophosphate catabolic process GO:0009169 57 0.015
regulation of purine nucleotide biosynthetic process GO:1900371 34 0.015
organic hydroxy compound biosynthetic process GO:1901617 77 0.015
regulation of hydrolase activity GO:0051336 246 0.014
Fly
positive regulation of nucleoside metabolic process GO:0045979 91 0.014
multicellular organismal homeostasis GO:0048871 164 0.014
cytosolic calcium ion homeostasis GO:0051480 70 0.014
ribonucleoside triphosphate catabolic process GO:0009203 199 0.014
response to oxidative stress GO:0006979 123 0.014
cellular protein complex assembly GO:0043623 116 0.014
cellular divalent inorganic cation homeostasis GO:0072503 127 0.014
purine containing compound biosynthetic process GO:0072522 70 0.014
regulation of inflammatory response GO:0050727 147 0.014
maintenance of location GO:0051235 89 0.014
regulation of cellular catabolic process GO:0031329 242 0.013
multicellular organism growth GO:0035264 161 0.013
regulation of protein ubiquitination GO:0031396 52 0.013
extrinsic apoptotic signaling pathway GO:0097191 126 0.013
regulation of transferase activity GO:0051338 263 0.013
negative regulation of oxidative stress induced intrinsic apoptotic signaling pathway GO:1902176 4 0.013
positive regulation of transmembrane transport GO:0034764 29 0.013
posttranscriptional regulation of gene expression GO:0010608 155 0.013
male gamete generation GO:0048232 285 0.013
negative regulation of intracellular signal transduction GO:1902532 167 0.013
organophosphate catabolic process GO:0046434 232 0.013
positive regulation of protein modification process GO:0031401 299 0.013
homeostasis of number of cells GO:0048872 210 0.013
adenine nucleotide transport GO:0051503 2 0.013
receptor mediated endocytosis GO:0006898 51 0.013
attachment of spindle microtubules to kinetochore GO:0008608 4 0.012
nucleoside monophosphate catabolic process GO:0009125 59 0.012
cellular nitrogen compound catabolic process GO:0044270 280 0.012
amine metabolic process GO:0009308 45 0.012
divalent inorganic cation homeostasis GO:0072507 138 0.012
cellular response to oxidative stress GO:0034599 76 0.012
synaptic vesicle transport GO:0048489 57 0.012
regulation of cellular ketone metabolic process GO:0010565 66 0.012
positive regulation of nucleotide metabolic process GO:0045981 114 0.012
inflammatory response GO:0006954 244 0.012
regulation of transporter activity GO:0032409 57 0.012
g protein coupled receptor signaling pathway GO:0007186 243 0.012
hexose catabolic process GO:0019320 3 0.012
cellular chemical homeostasis GO:0055082 215 0.012
striated muscle tissue development GO:0014706 293 0.012
sensory perception GO:0007600 245 0.012
regulation of neuron death GO:1901214 134 0.012
carboxylic acid transport GO:0046942 100 0.012
regulation of transmembrane transport GO:0034762 128 0.012
organism emergence from protective structure GO:0071684 4 0.012
nucleoside monophosphate biosynthetic process GO:0009124 12 0.011
response to organic cyclic compound GO:0014070 198 0.011
mitochondrial calcium ion homeostasis GO:0051560 7 0.011
negative regulation of cellular protein metabolic process GO:0032269 247 0.011
positive regulation of programmed cell death GO:0043068 218 0.011
Fly
quinone biosynthetic process GO:1901663 4 0.011
regulation of cytokine production GO:0001817 266 0.011
tissue homeostasis GO:0001894 115 0.011
cellular response to organonitrogen compound GO:0071417 145 0.011
positive regulation of nucleotide biosynthetic process GO:0030810 26 0.011
purine nucleotide catabolic process GO:0006195 211 0.011
branching morphogenesis of an epithelial tube GO:0048754 159 0.011
peptidyl amino acid modification GO:0018193 336 0.011
iron coordination entity transport GO:1901678 5 0.011
cytokine production GO:0001816 319 0.011
regulation of peptidase activity GO:0052547 96 0.011
Fly
epithelial cell development GO:0002064 159 0.011
dicarboxylic acid metabolic process GO:0043648 18 0.011
Human
negative regulation of cellular component organization GO:0051129 194 0.011
lateral inhibition GO:0046331 1 0.011
neuron death GO:0070997 154 0.011
organic hydroxy compound transport GO:0015850 93 0.010
multi multicellular organism process GO:0044706 109 0.010
l glutamate import into cell GO:1990123 3 0.010
porphyrin containing compound biosynthetic process GO:0006779 16 0.010
regulation of interleukin 8 production GO:0032677 3 0.010
negative regulation of phosphorylation GO:0042326 166 0.010
response to molecule of bacterial origin GO:0002237 143 0.010

Mdh2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
immune system disease DOID:2914 0 0.157
disease of anatomical entity DOID:7 0 0.157
hematopoietic system disease DOID:74 0 0.157
nervous system disease DOID:863 0 0.090
cancer DOID:162 0 0.052
disease of cellular proliferation DOID:14566 0 0.052
disease of metabolism DOID:0014667 0 0.040
inherited metabolic disorder DOID:655 0 0.030
central nervous system disease DOID:331 0 0.019
neurodegenerative disease DOID:1289 0 0.015
organ system cancer DOID:0050686 0 0.013
sensory system disease DOID:0050155 0 0.012
eye and adnexa disease DOID:1492 0 0.012
eye disease DOID:5614 0 0.012
phaeochromocytoma DOID:0050771 0 0.010
cell type benign neoplasm DOID:0060084 0 0.010
benign neoplasm DOID:0060072 0 0.010