Mus musculus

11 known processes

Mdm4

transformed mouse 3T3 cell double minute 4

(Aliases: AU018793,4933417N07Rik,Mdmx,AL023055,AU021806,AA414968,C85810)

Mdm4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular response to dna damage stimulus GO:0006974 207 0.999
Human
signal transduction involved in mitotic dna damage checkpoint GO:1902402 3 0.994
dna metabolic process GO:0006259 303 0.991
negative regulation of cell cycle arrest GO:0071157 1 0.972
negative regulation of cell cycle GO:0045786 123 0.966
signal transduction involved in dna integrity checkpoint GO:0072401 3 0.962
signal transduction by p53 class mediator GO:0072331 51 0.958
Human
cellular response to gamma radiation GO:0071480 4 0.958
protein modification by small protein conjugation or removal GO:0070647 207 0.931
Mouse
dna repair GO:0006281 107 0.927
modification dependent macromolecule catabolic process GO:0043632 133 0.910
dna damage response signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 3 0.907
protein modification by small protein conjugation GO:0032446 187 0.899
Mouse
signal transduction involved in dna damage checkpoint GO:0072422 3 0.896
chromatin modification GO:0016568 187 0.879
positive regulation of apoptotic process GO:0043065 217 0.867
negative regulation of mitotic cell cycle GO:0045930 58 0.861
regulation of protein stability GO:0031647 52 0.859
Human
negative regulation of phosphorylation GO:0042326 166 0.857
signal transduction involved in mitotic dna integrity checkpoint GO:1902403 3 0.852
mitotic g1 dna damage checkpoint GO:0031571 4 0.846
protein maturation GO:0051604 176 0.845
intracellular signal transduction involved in g1 dna damage checkpoint GO:1902400 3 0.842
response to x ray GO:0010165 11 0.826
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.800
signal transduction involved in cell cycle checkpoint GO:0072395 3 0.798
traversing start control point of mitotic cell cycle GO:0007089 2 0.788
Mouse
negative regulation of dna replication GO:0008156 4 0.765
ubiquitin dependent protein catabolic process GO:0006511 129 0.764
regulation of mitotic cell cycle phase transition GO:1901990 73 0.756
Mouse
g1 s transition of mitotic cell cycle GO:0000082 57 0.742
Mouse
regulation of cell cycle GO:0051726 281 0.737
Mouse
negative regulation of nik nf kappab signaling GO:1901223 2 0.734
cell cycle checkpoint GO:0000075 47 0.728
protein processing GO:0016485 163 0.725
modification dependent protein catabolic process GO:0019941 133 0.719
positive regulation of cell cycle g1 s phase transition GO:1902808 9 0.716
Mouse
negative regulation of dna damage response signal transduction by p53 class mediator GO:0043518 5 0.709
positive regulation of macroautophagy GO:0016239 3 0.701
intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 35 0.696
signal transduction involved in mitotic cell cycle checkpoint GO:0072413 3 0.695
regulation of cellular response to stress GO:0080135 159 0.692
negative regulation of protein modification process GO:0031400 163 0.689
negative regulation of cellular protein metabolic process GO:0032269 247 0.679
regulation of transferase activity GO:0051338 263 0.677
response to antibiotic GO:0046677 11 0.675
negative regulation of protein metabolic process GO:0051248 282 0.662
Human
double strand break repair GO:0006302 48 0.659
regulation of cell cycle process GO:0010564 160 0.647
Mouse
meiotic cell cycle GO:0051321 122 0.634
skeletal system development GO:0001501 356 0.630
protein ubiquitination GO:0016567 171 0.628
Mouse
cellular protein catabolic process GO:0044257 155 0.612
regulation of cellular catabolic process GO:0031329 242 0.610
protein localization to organelle GO:0033365 185 0.604
regionalization GO:0003002 337 0.603
negative regulation of phosphate metabolic process GO:0045936 184 0.602
appendage morphogenesis GO:0035107 149 0.595
leukocyte differentiation GO:0002521 342 0.583
positive regulation of cell death GO:0010942 224 0.582
negative regulation of phosphorus metabolic process GO:0010563 184 0.569
negative regulation of cell cycle process GO:0010948 69 0.556
intrinsic apoptotic signaling pathway GO:0097193 132 0.555
negative regulation of molecular function GO:0044092 258 0.547
homeostasis of number of cells GO:0048872 210 0.541
negative regulation of mitotic cell cycle phase transition GO:1901991 45 0.540
cell aging GO:0007569 35 0.537
negative regulation of protein phosphorylation GO:0001933 126 0.536
regulation of protein maturation GO:1903317 96 0.534
positive regulation of protein phosphorylation GO:0001934 242 0.532
regulation of intrinsic apoptotic signaling pathway GO:2001242 61 0.529
negative regulation of intracellular signal transduction GO:1902532 167 0.516
cell cycle g1 s phase transition GO:0044843 57 0.514
Mouse
regulation of cell cycle phase transition GO:1901987 77 0.514
Mouse
proteasomal protein catabolic process GO:0010498 98 0.507
peptidyl amino acid modification GO:0018193 336 0.499
nuclear division GO:0000280 158 0.497
amine metabolic process GO:0009308 45 0.496
cell cycle arrest GO:0007050 37 0.494
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.493
mitotic cell cycle checkpoint GO:0007093 31 0.493
b cell activation GO:0042113 161 0.488
glial cell apoptotic process GO:0034349 3 0.486
regulation of kinase activity GO:0043549 249 0.486
regulation of cellular amine metabolic process GO:0033238 20 0.485
regulation of response to dna damage stimulus GO:2001020 34 0.485
release of cytochrome c from mitochondria GO:0001836 23 0.480
negative regulation of cellular amine metabolic process GO:0033239 1 0.480
ossification GO:0001503 216 0.477
regulation of apoptotic signaling pathway GO:2001233 197 0.458
dna damage response signal transduction by p53 class mediator GO:0030330 19 0.456
Human
regulation of protein localization GO:0032880 231 0.455
cellular amine metabolic process GO:0044106 44 0.444
epithelial cell proliferation GO:0050673 174 0.437
regulation of protein kinase activity GO:0045859 232 0.435
ras protein signal transduction GO:0007265 77 0.435
fibroblast proliferation GO:0048144 35 0.434
regulation of proteolysis GO:0030162 164 0.430
cellular response to ionizing radiation GO:0071479 11 0.420
mitotic cell cycle arrest GO:0071850 4 0.419
cellular response to antibiotic GO:0071236 4 0.418
positive regulation of proteolysis GO:0045862 85 0.416
positive regulation of apoptotic signaling pathway GO:2001235 95 0.411
nucleotide excision repair GO:0006289 13 0.410
peptidyl lysine modification GO:0018205 77 0.406
dna integrity checkpoint GO:0031570 28 0.406
negative regulation of transferase activity GO:0051348 85 0.404
cellular ketone metabolic process GO:0042180 84 0.402
response to oxygen levels GO:0070482 62 0.402
Human
protein catabolic process GO:0030163 221 0.396
Human Mouse
protein localization to nucleus GO:0034504 121 0.392
limb development GO:0060173 166 0.391
dna damage checkpoint GO:0000077 26 0.387
negative regulation of cell cycle phase transition GO:1901988 48 0.385
regulation of mitotic cell cycle GO:0007346 126 0.384
Mouse
negative regulation of proteolysis GO:0045861 74 0.384
leukocyte proliferation GO:0070661 172 0.382
regulation of cell cycle arrest GO:0071156 12 0.382
cellular macromolecule catabolic process GO:0044265 206 0.377
germ cell development GO:0007281 185 0.377
negative regulation of map kinase activity GO:0043407 34 0.375
reactive oxygen species metabolic process GO:0072593 84 0.360
negative regulation of kinase activity GO:0033673 81 0.356
skeletal muscle organ development GO:0060538 163 0.355
negative regulation of leukocyte differentiation GO:1902106 51 0.353
signal transduction involved in mitotic g1 dna damage checkpoint GO:0072431 3 0.351
negative regulation of cell proliferation GO:0008285 296 0.350
cellular senescence GO:0090398 11 0.350
negative regulation of immune system process GO:0002683 209 0.347
dna replication GO:0006260 52 0.336
telomere capping GO:0016233 4 0.326
negative regulation of protein maturation GO:1903318 79 0.325
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 40 0.325
regulation of nucleocytoplasmic transport GO:0046822 73 0.324
regulation of cellular ketone metabolic process GO:0010565 66 0.323
cellular amino acid metabolic process GO:0006520 103 0.320
regulation of reactive oxygen species metabolic process GO:2000377 40 0.313
cellular response to radiation GO:0071478 28 0.309
positive regulation of cellular amine metabolic process GO:0033240 5 0.309
positive regulation of chromatin modification GO:1903310 28 0.304
mitotic cell cycle GO:0000278 195 0.304
Mouse
regulation of ossification GO:0030278 112 0.300
regulation of leukocyte apoptotic process GO:2000106 56 0.297
regulation of chromatin organization GO:1902275 57 0.293
negative regulation of apoptotic signaling pathway GO:2001234 104 0.291
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 56 0.291
negative regulation of protein serine threonine kinase activity GO:0071901 49 0.289
peptidyl serine modification GO:0018209 83 0.288
regulation of protein catabolic process GO:0042176 108 0.284
Human
mitochondrion degradation GO:0000422 3 0.278
regulation of cell cycle g1 s phase transition GO:1902806 35 0.265
Mouse
hematopoietic progenitor cell differentiation GO:0002244 143 0.262
embryonic limb morphogenesis GO:0030326 126 0.259
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.257
positive regulation of g1 s transition of mitotic cell cycle GO:1900087 9 0.255
Mouse
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.254
negative regulation of phosphatidylinositol 3 kinase activity GO:0043553 1 0.253
positive regulation of cell cycle phase transition GO:1901989 17 0.252
Mouse
positive regulation of cellular catabolic process GO:0031331 148 0.251
apoptotic signaling pathway GO:0097190 306 0.251
negative regulation of growth GO:0045926 99 0.251
regulation of hydrolase activity GO:0051336 246 0.250
response to ionizing radiation GO:0010212 42 0.249
stem cell differentiation GO:0048863 268 0.237
lens development in camera type eye GO:0002088 62 0.237
mitochondrial dna repair GO:0043504 3 0.235
regulation of mapk cascade GO:0043408 248 0.235
response to endoplasmic reticulum stress GO:0034976 53 0.232
negative regulation of intracellular protein transport GO:0090317 27 0.232
signal transduction in response to dna damage GO:0042770 21 0.231
Human
small gtpase mediated signal transduction GO:0007264 97 0.230
stem cell development GO:0048864 219 0.230
protein autophosphorylation GO:0046777 61 0.230
stem cell maintenance GO:0019827 130 0.229
positive regulation of neuron death GO:1901216 28 0.226
methylation GO:0032259 134 0.224
regulation of protein processing GO:0070613 96 0.223
positive regulation of growth GO:0045927 104 0.221
cell fate commitment GO:0045165 210 0.221
response to radiation GO:0009314 165 0.220
axon guidance GO:0007411 141 0.215
positive regulation of kinase activity GO:0033674 155 0.215
protein methylation GO:0006479 81 0.214
female genitalia morphogenesis GO:0048807 3 0.214
cell division GO:0051301 120 0.210
embryonic organ morphogenesis GO:0048562 276 0.208
regulation of g1 s transition of mitotic cell cycle GO:2000045 35 0.207
Mouse
positive regulation of keratinocyte proliferation GO:0010838 4 0.206
lymphocyte proliferation GO:0046651 164 0.206
regulation of intracellular protein transport GO:0033157 82 0.204
positive regulation of striated muscle cell apoptotic process GO:0010663 3 0.203
regulation of protein localization to nucleus GO:1900180 60 0.201
regulation of proteasomal protein catabolic process GO:0061136 46 0.201
macromolecule catabolic process GO:0009057 281 0.201
Human Mouse
epidermal growth factor receptor signaling pathway via positive regulation of nf kappab transcription factor activity GO:0038167 1 0.199
regulation of histone modification GO:0031056 56 0.198
neuron death GO:0070997 154 0.198
appendage development GO:0048736 166 0.197
response to growth factor GO:0070848 198 0.192
regulation of endopeptidase activity GO:0052548 89 0.190
skeletal system morphogenesis GO:0048705 203 0.189
negative regulation of mapk cascade GO:0043409 65 0.188
negative regulation of g1 s transition of mitotic cell cycle GO:2000134 18 0.184
cytoplasmic transport GO:0016482 234 0.184
cell type specific apoptotic process GO:0097285 268 0.183
negative regulation of epithelial cell proliferation GO:0050680 64 0.181
positive regulation of mitotic cell cycle GO:0045931 41 0.180
Mouse
regulation of cellular protein catabolic process GO:1903362 61 0.180
chemotaxis GO:0006935 247 0.179
positive regulation of programmed cell death GO:0043068 218 0.179
positive regulation of organelle organization GO:0010638 128 0.179
response to reactive oxygen species GO:0000302 56 0.178
negative regulation of response to dna damage stimulus GO:2001021 10 0.178
bone development GO:0060348 120 0.175
chromosome segregation GO:0007059 48 0.175
apoptotic mitochondrial changes GO:0008637 48 0.174
cellular response to growth factor stimulus GO:0071363 197 0.174
central nervous system neuron differentiation GO:0021953 162 0.169
histone modification GO:0016570 159 0.163
cellular response to x ray GO:0071481 2 0.160
programmed necrotic cell death GO:0097300 28 0.159
regulation of leukocyte proliferation GO:0070663 121 0.158
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.157
protein ubiquitination involved in ubiquitin dependent protein catabolic process GO:0042787 25 0.157
retina development in camera type eye GO:0060041 119 0.157
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 36 0.155
meiotic cell cycle process GO:1903046 77 0.155
positive regulation of protein modification process GO:0031401 299 0.155
positive regulation of peptidase activity GO:0010952 49 0.153
regulation of fibroblast proliferation GO:0048145 34 0.152
regulation of protein ubiquitination GO:0031396 52 0.152
regulation of epithelial cell proliferation GO:0050678 141 0.152
epidermal growth factor receptor signaling pathway via i kappab kinase nf kappab cascade GO:0038168 1 0.151
positive regulation of mitotic cell cycle phase transition GO:1901992 17 0.151
Mouse
regulation of neuron death GO:1901214 134 0.148
mitotic cell cycle process GO:1903047 159 0.147
Mouse
negative regulation of cellular component organization GO:0051129 194 0.147
response to hypoxia GO:0001666 58 0.146
Human
regulation of leukocyte differentiation GO:1902105 159 0.145
activation of cysteine type endopeptidase activity GO:0097202 27 0.140
negative regulation of lymphocyte activation GO:0051250 91 0.138
regulation of lymphocyte differentiation GO:0045619 107 0.137
macroautophagy GO:0016236 21 0.136
regulation of lymphocyte activation GO:0051249 240 0.136
posttranscriptional regulation of gene expression GO:0010608 155 0.135
Human
regulation of chromatin modification GO:1903308 57 0.134
t cell differentiation in thymus GO:0033077 77 0.134
erythrocyte differentiation GO:0030218 88 0.132
positive regulation of binding GO:0051099 49 0.132
positive regulation of cell cycle process GO:0090068 61 0.128
Mouse
cellular response to oxygen levels GO:0071453 20 0.127
Human
regulation of ion transport GO:0043269 215 0.127
negative regulation of fibroblast proliferation GO:0048147 14 0.127
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.126
striated muscle tissue development GO:0014706 293 0.126
dna recombination GO:0006310 92 0.126
regulation of protein transport GO:0051223 163 0.126
regulation of defense response GO:0031347 233 0.125
dendrite development GO:0016358 115 0.123
dna conformation change GO:0071103 37 0.123
reciprocal dna recombination GO:0035825 16 0.122
dna biosynthetic process GO:0071897 22 0.122
multicellular organism growth GO:0035264 161 0.122
positive regulation of cardiac muscle cell apoptotic process GO:0010666 3 0.122
response to light stimulus GO:0009416 135 0.121
dna damage response signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 2 0.121
myeloid cell apoptotic process GO:0033028 22 0.121
negative regulation of cell cycle g1 s phase transition GO:1902807 18 0.121
cellular response to oxidative stress GO:0034599 76 0.120
digestive tract development GO:0048565 190 0.120
positive regulation of protein modification by small protein conjugation or removal GO:1903322 30 0.120
muscle cell differentiation GO:0042692 261 0.120
mitochondrial membrane organization GO:0007006 26 0.119
telomere maintenance in response to dna damage GO:0043247 4 0.119
leukocyte homeostasis GO:0001776 79 0.119
embryonic appendage morphogenesis GO:0035113 126 0.118
regulation of intracellular transport GO:0032386 159 0.118
positive regulation of muscle cell apoptotic process GO:0010661 6 0.116
regulation of autophagy GO:0010506 30 0.116
gland development GO:0048732 330 0.116
macromolecule deacylation GO:0098732 37 0.116
lymphocyte homeostasis GO:0002260 64 0.115
neuron projection guidance GO:0097485 141 0.114
regulation of cellular amino acid metabolic process GO:0006521 5 0.113
locomotory behavior GO:0007626 195 0.113
negative regulation of jun kinase activity GO:0043508 9 0.112
cellular response to organonitrogen compound GO:0071417 145 0.110
covalent chromatin modification GO:0016569 163 0.110
regulation of body fluid levels GO:0050878 162 0.108
regulation of neuron apoptotic process GO:0043523 122 0.108
cation transport GO:0006812 399 0.106
production of molecular mediator of immune response GO:0002440 103 0.105
oxidation reduction process GO:0055114 342 0.102
cellular ion homeostasis GO:0006873 165 0.102
embryonic skeletal system morphogenesis GO:0048704 91 0.102
wound healing GO:0042060 157 0.101
regulation of protein import into nucleus GO:0042306 52 0.100
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 16 0.100
dna modification GO:0006304 50 0.098
myeloid cell homeostasis GO:0002262 114 0.098
regulation of protein targeting GO:1903533 61 0.097
organelle fission GO:0048285 170 0.097
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 57 0.097
chromatin organization GO:0006325 206 0.097
negative regulation of organelle organization GO:0010639 90 0.096
positive regulation of neuron apoptotic process GO:0043525 25 0.095
mammary gland epithelium development GO:0061180 65 0.094
negative regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032435 15 0.094
t cell proliferation GO:0042098 120 0.094
protection from non homologous end joining at telomere GO:0031848 4 0.093
renal system development GO:0072001 225 0.093
reciprocal meiotic recombination GO:0007131 16 0.093
purine ribonucleotide metabolic process GO:0009150 290 0.092
cellular response to light stimulus GO:0071482 19 0.092
negative regulation of nuclear division GO:0051784 19 0.092
immune response activating signal transduction GO:0002757 116 0.092
developmental maturation GO:0021700 193 0.091
nucleocytoplasmic transport GO:0006913 139 0.091
generation of precursor metabolites and energy GO:0006091 103 0.091
endothelial cell apoptotic process GO:0072577 9 0.090
negative regulation of cell division GO:0051782 24 0.090
carbohydrate transport GO:0008643 62 0.089
positive regulation of lymphocyte apoptotic process GO:0070230 13 0.088
inflammatory response GO:0006954 244 0.088
cellular response to lipid GO:0071396 145 0.088
neuron apoptotic process GO:0051402 142 0.088
muscle cell apoptotic process GO:0010657 18 0.088
t cell activation GO:0042110 289 0.088
axonogenesis GO:0007409 274 0.087
regulation of cellular component biogenesis GO:0044087 181 0.087
notch signaling pathway GO:0007219 71 0.087
muscle tissue development GO:0060537 308 0.086
cellular response to drug GO:0035690 15 0.086
response to oxidative stress GO:0006979 123 0.086
respiratory tube development GO:0030323 167 0.086
response to acid chemical GO:0001101 111 0.085
skeletal muscle cell differentiation GO:0035914 66 0.085
regulation of map kinase activity GO:0043405 120 0.085
regulation of b cell activation GO:0050864 81 0.085
jnk cascade GO:0007254 72 0.085
regulation of cellular component size GO:0032535 121 0.085
somatic stem cell maintenance GO:0035019 47 0.084
regulation of chromosome organization GO:0033044 83 0.084
somatic cell dna recombination GO:0016444 51 0.084
positive regulation of nucleotide metabolic process GO:0045981 114 0.083
cellular response to acid chemical GO:0071229 68 0.083
aromatic compound catabolic process GO:0019439 286 0.083
negative regulation of reactive oxygen species metabolic process GO:2000378 10 0.082
female gamete generation GO:0007292 74 0.082
regulation of cysteine type endopeptidase activity GO:2000116 65 0.082
regulation of peptidyl tyrosine phosphorylation GO:0050730 93 0.081
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 27 0.080
positive regulation of cellular protein catabolic process GO:1903364 34 0.080
signal transduction in absence of ligand GO:0038034 55 0.080
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.080
sequestering of calcium ion GO:0051208 18 0.079
b cell proliferation GO:0042100 53 0.079
cation homeostasis GO:0055080 212 0.079
regulation of establishment of protein localization GO:0070201 181 0.078
anatomical structure homeostasis GO:0060249 145 0.078
stress activated protein kinase signaling cascade GO:0031098 81 0.077
camera type eye development GO:0043010 266 0.077
dna packaging GO:0006323 30 0.076
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 34 0.076
necrotic cell death GO:0070265 30 0.076
regulation of organelle organization GO:0033043 289 0.076
muscle cell development GO:0055001 133 0.075
base excision repair GO:0006284 9 0.075
limb morphogenesis GO:0035108 149 0.074
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902043 13 0.074
embryonic epithelial tube formation GO:0001838 130 0.074
positive regulation of histone modification GO:0031058 28 0.073
negative regulation of cyclin dependent protein serine threonine kinase activity GO:0045736 9 0.073
membrane organization GO:0061024 245 0.073
dna endoreduplication GO:0042023 4 0.072
response to organic cyclic compound GO:0014070 198 0.072
myeloid leukocyte differentiation GO:0002573 119 0.072
t cell differentiation GO:0030217 174 0.072
regulation of neuron differentiation GO:0045664 281 0.071
columnar cuboidal epithelial cell differentiation GO:0002065 82 0.071
response to drug GO:0042493 75 0.071
wnt signaling pathway GO:0016055 188 0.070
neural tube development GO:0021915 160 0.070
microtubule cytoskeleton organization GO:0000226 157 0.070
digestive system development GO:0055123 200 0.070
branching morphogenesis of an epithelial tube GO:0048754 159 0.070
response to lipopolysaccharide GO:0032496 128 0.069
regulation of protein modification by small protein conjugation or removal GO:1903320 57 0.069
cellular response to external stimulus GO:0071496 88 0.069
positive regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032436 23 0.069
cellular divalent inorganic cation homeostasis GO:0072503 127 0.069
mesoderm development GO:0007498 100 0.068
positive regulation of cytokine biosynthetic process GO:0042108 40 0.068
negative regulation of peptidase activity GO:0010466 46 0.067
action potential GO:0001508 78 0.067
regulation of protein deacetylation GO:0090311 17 0.067
male gamete generation GO:0048232 285 0.067
kidney development GO:0001822 213 0.066
positive regulation of cell cycle arrest GO:0071158 10 0.066
multicellular organismal response to stress GO:0033555 62 0.065
gene silencing GO:0016458 38 0.065
intracellular protein transport GO:0006886 204 0.064
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 31 0.064
histone deacetylation GO:0016575 26 0.064
negative regulation of lipid kinase activity GO:0090219 1 0.063
purine ribonucleotide catabolic process GO:0009154 208 0.063
cellular response to decreased oxygen levels GO:0036294 18 0.063
Human
pallium development GO:0021543 120 0.063
protein targeting GO:0006605 143 0.063
cellular response to hypoxia GO:0071456 17 0.062
Human
cellular response to biotic stimulus GO:0071216 92 0.062
meiotic nuclear division GO:0007126 115 0.062
myotube differentiation GO:0014902 105 0.062
multicellular organismal homeostasis GO:0048871 164 0.061
morphogenesis of embryonic epithelium GO:0016331 159 0.061
chromatin silencing GO:0006342 15 0.061
nephron development GO:0072006 109 0.061
negative regulation of wnt signaling pathway GO:0030178 73 0.060
b cell differentiation GO:0030183 78 0.060
positive regulation of chromosome organization GO:2001252 33 0.060
cellular calcium ion homeostasis GO:0006874 119 0.060
muscle fiber development GO:0048747 76 0.060
positive regulation of nervous system development GO:0051962 221 0.059
somatic recombination of immunoglobulin gene segments GO:0016447 42 0.059
positive regulation of cell cycle GO:0045787 92 0.059
Mouse
positive regulation of erk1 and erk2 cascade GO:0070374 47 0.059
myeloid cell differentiation GO:0030099 233 0.059
response to transforming growth factor beta GO:0071559 88 0.059
immune response regulating signaling pathway GO:0002764 125 0.058
negative regulation of nervous system development GO:0051961 156 0.058
regulation of protein binding GO:0043393 60 0.058
syncytium formation by plasma membrane fusion GO:0000768 42 0.058
neural tube closure GO:0001843 90 0.058
negative regulation of intracellular transport GO:0032387 38 0.057
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 62 0.057
protein modification by small protein removal GO:0070646 21 0.057
second messenger mediated signaling GO:0019932 73 0.057
regulation of muscle tissue development GO:1901861 97 0.057
negative regulation of chromosome organization GO:2001251 30 0.057
organic cyclic compound catabolic process GO:1901361 295 0.056
cell growth GO:0016049 130 0.056
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 61 0.056
urogenital system development GO:0001655 261 0.056
response to starvation GO:0042594 65 0.056
regulation of t cell differentiation GO:0045580 83 0.056
regulation of tumor necrosis factor superfamily cytokine production GO:1903555 50 0.056
rna dependent dna replication GO:0006278 3 0.056
cellular response to nitric oxide GO:0071732 4 0.055
regulation of angiogenesis GO:0045765 81 0.055
cell cycle g2 m phase transition GO:0044839 20 0.055
purine ribonucleoside catabolic process GO:0046130 205 0.055
oogenesis GO:0048477 56 0.055
cardiac right ventricle formation GO:0003219 3 0.054
regulation of histone methylation GO:0031060 30 0.054
metal ion homeostasis GO:0055065 189 0.054
negative regulation of neuron apoptotic process GO:0043524 92 0.054
skin development GO:0043588 220 0.054
embryonic digit morphogenesis GO:0042733 56 0.054
meiosis i GO:0007127 60 0.054
regulation of muscle cell apoptotic process GO:0010660 17 0.054
regulation of cytoplasmic transport GO:1903649 112 0.054
phagocytosis GO:0006909 66 0.054
cell maturation GO:0048469 127 0.054
response to tumor necrosis factor GO:0034612 26 0.053
cellular chemical homeostasis GO:0055082 215 0.053
negative regulation of leukocyte proliferation GO:0070664 46 0.053
positive regulation of myeloid cell differentiation GO:0045639 43 0.053
positive regulation of smooth muscle cell migration GO:0014911 4 0.053
bone morphogenesis GO:0060349 78 0.053
negative regulation of cellular catabolic process GO:0031330 47 0.053
regulation of peptidase activity GO:0052547 96 0.052
negative regulation of lymphocyte proliferation GO:0050672 45 0.052
regulation of nucleotide metabolic process GO:0006140 169 0.052
regulation of multi organism process GO:0043900 111 0.052
digestive tract morphogenesis GO:0048546 147 0.051
protein import GO:0017038 101 0.051
calcium ion homeostasis GO:0055074 127 0.051
cellular response to extracellular stimulus GO:0031668 81 0.051
mitochondrial transport GO:0006839 36 0.051
ribonucleoside catabolic process GO:0042454 206 0.051
cellular response to peptide GO:1901653 92 0.050

Mdm4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.686
disease of cellular proliferation DOID:14566 0 0.686
organ system cancer DOID:0050686 0 0.686
immune system cancer DOID:0060083 0 0.297
hematologic cancer DOID:2531 0 0.297
breast cancer DOID:1612 0 0.115
thoracic cancer DOID:5093 0 0.115
gastrointestinal system cancer DOID:3119 0 0.081
liver carcinoma DOID:686 0 0.081
liver cancer DOID:3571 0 0.081
large intestine cancer DOID:5672 0 0.074
colon cancer DOID:219 0 0.074
intestinal cancer DOID:10155 0 0.074
colorectal cancer DOID:9256 0 0.074