Mus musculus

0 known processes

Metap2

methionine aminopeptidase 2

(Aliases: AL024412,A930035J23Rik,p67,MGC102452,AU014659,Amp2,4930584B20Rik,AI047573,Mnpep,p67eIF2)

Metap2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
translation GO:0006412 93 0.478
aromatic compound catabolic process GO:0019439 286 0.142
male gamete generation GO:0048232 285 0.130
cellular macromolecule catabolic process GO:0044265 206 0.127
organic cyclic compound catabolic process GO:1901361 295 0.116
rna processing GO:0006396 105 0.114
cellular response to dna damage stimulus GO:0006974 207 0.112
mitotic cell cycle process GO:1903047 159 0.101
apoptotic signaling pathway GO:0097190 306 0.100
macromolecule catabolic process GO:0009057 281 0.098
nucleobase containing small molecule metabolic process GO:0055086 352 0.092
mrna metabolic process GO:0016071 84 0.086
cytoplasmic transport GO:0016482 234 0.083
rna splicing GO:0008380 54 0.082
ribose phosphate metabolic process GO:0019693 291 0.078
cellular nitrogen compound catabolic process GO:0044270 280 0.078
organelle fission GO:0048285 170 0.077
cellular amino acid metabolic process GO:0006520 103 0.076
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.076
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.069
heterocycle catabolic process GO:0046700 280 0.068
purine ribonucleotide catabolic process GO:0009154 208 0.067
nucleotide catabolic process GO:0009166 217 0.067
ribonucleoside triphosphate catabolic process GO:0009203 199 0.066
purine ribonucleotide metabolic process GO:0009150 290 0.064
ribonucleoside catabolic process GO:0042454 206 0.063
purine nucleoside triphosphate catabolic process GO:0009146 203 0.063
mitotic cell cycle GO:0000278 195 0.062
dna metabolic process GO:0006259 303 0.061
spermatogenesis GO:0007283 284 0.060
positive regulation of apoptotic process GO:0043065 217 0.060
regulation of apoptotic signaling pathway GO:2001233 197 0.060
organonitrogen compound catabolic process GO:1901565 264 0.058
chromatin modification GO:0016568 187 0.058
nucleoside catabolic process GO:0009164 206 0.056
purine containing compound metabolic process GO:0072521 311 0.056
germ cell development GO:0007281 185 0.056
purine containing compound catabolic process GO:0072523 213 0.054
ribonucleotide catabolic process GO:0009261 208 0.053
nucleoside phosphate catabolic process GO:1901292 222 0.053
ribonucleoside metabolic process GO:0009119 245 0.052
purine nucleoside metabolic process GO:0042278 241 0.051
nucleoside triphosphate metabolic process GO:0009141 230 0.051
purine nucleotide metabolic process GO:0006163 302 0.051
purine nucleoside catabolic process GO:0006152 205 0.050
atp metabolic process GO:0046034 75 0.050
nucleoside metabolic process GO:0009116 246 0.050
atp catabolic process GO:0006200 55 0.050
purine ribonucleoside metabolic process GO:0046128 241 0.048
purine nucleoside triphosphate metabolic process GO:0009144 226 0.048
microtubule based process GO:0007017 236 0.048
cellular amine metabolic process GO:0044106 44 0.048
nucleoside triphosphate catabolic process GO:0009143 205 0.047
ribonucleotide metabolic process GO:0009259 291 0.047
chromatin organization GO:0006325 206 0.047
microtubule cytoskeleton organization GO:0000226 157 0.046
amine metabolic process GO:0009308 45 0.046
positive regulation of cell death GO:0010942 224 0.045
glycosyl compound metabolic process GO:1901657 246 0.045
nucleic acid phosphodiester bond hydrolysis GO:0090305 49 0.044
organelle assembly GO:0070925 177 0.043
nitrogen compound transport GO:0071705 271 0.042
nucleotide metabolic process GO:0009117 332 0.041
posttranscriptional regulation of gene expression GO:0010608 155 0.041
ras protein signal transduction GO:0007265 77 0.039
purine ribonucleoside catabolic process GO:0046130 205 0.039
positive regulation of apoptotic signaling pathway GO:2001235 95 0.038
histone modification GO:0016570 159 0.038
ribonucleoside monophosphate metabolic process GO:0009161 80 0.037
dna repair GO:0006281 107 0.036
regulation of cellular response to stress GO:0080135 159 0.036
ribonucleoside triphosphate metabolic process GO:0009199 220 0.036
mitotic nuclear division GO:0007067 48 0.036
regulation of cellular component biogenesis GO:0044087 181 0.036
positive regulation of programmed cell death GO:0043068 218 0.035
purine nucleotide catabolic process GO:0006195 211 0.035
dna conformation change GO:0071103 37 0.035
purine nucleoside monophosphate catabolic process GO:0009128 58 0.034
nucleoside monophosphate metabolic process GO:0009123 85 0.034
negative regulation of intracellular signal transduction GO:1902532 167 0.034
nuclear transport GO:0051169 139 0.033
developmental maturation GO:0021700 193 0.033
carbohydrate derivative catabolic process GO:1901136 231 0.033
regulation of cell motility GO:2000145 236 0.032
response to organic cyclic compound GO:0014070 198 0.032
cellular ketone metabolic process GO:0042180 84 0.032
regulation of translation GO:0006417 71 0.031
gene silencing GO:0016458 38 0.031
glycosyl compound catabolic process GO:1901658 206 0.031
nucleocytoplasmic transport GO:0006913 139 0.030
response to organonitrogen compound GO:0010243 246 0.030
positive regulation of cellular component biogenesis GO:0044089 94 0.030
nucleoside phosphate metabolic process GO:0006753 338 0.029
organophosphate catabolic process GO:0046434 232 0.029
negative regulation of cellular component organization GO:0051129 194 0.028
negative regulation of cell proliferation GO:0008285 296 0.028
positive regulation of cellular amine metabolic process GO:0033240 5 0.028
protein catabolic process GO:0030163 221 0.028
nuclear division GO:0000280 158 0.028
negative regulation of protein metabolic process GO:0051248 282 0.027
regulation of protein localization GO:0032880 231 0.027
endocytosis GO:0006897 168 0.027
Worm
gene silencing by rna GO:0031047 19 0.026
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.025
regulation of organelle organization GO:0033043 289 0.025
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 43 0.025
rna transport GO:0050658 18 0.025
regulation of cellular amino acid metabolic process GO:0006521 5 0.025
single organism nuclear import GO:1902593 95 0.025
negative regulation of molecular function GO:0044092 258 0.025
protein processing GO:0016485 163 0.025
Human
response to growth factor GO:0070848 198 0.025
purine ribonucleoside monophosphate catabolic process GO:0009169 57 0.024
regulation of protein catabolic process GO:0042176 108 0.024
intracellular protein transport GO:0006886 204 0.024
lateral inhibition GO:0046331 1 0.023
regulation of cell migration GO:0030334 219 0.023
spermatid differentiation GO:0048515 115 0.023
spermatid development GO:0007286 108 0.023
mitotic sister chromatid segregation GO:0000070 14 0.023
locomotory behavior GO:0007626 195 0.023
protein targeting GO:0006605 143 0.023
response to oxidative stress GO:0006979 123 0.022
striated muscle tissue development GO:0014706 293 0.022
adult behavior GO:0030534 135 0.022
rna interference GO:0016246 2 0.022
regulation of cell cycle GO:0051726 281 0.022
stem cell development GO:0048864 219 0.022
cell maturation GO:0048469 127 0.022
purine nucleoside monophosphate metabolic process GO:0009126 81 0.022
regulation of cellular catabolic process GO:0031329 242 0.022
maturation of 5 8s rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna GO:0000466 1 0.021
mrna splicing via spliceosome GO:0000398 43 0.021
negative regulation of cellular protein metabolic process GO:0032269 247 0.021
cell growth GO:0016049 130 0.021
maternal determination of anterior posterior axis embryo GO:0008358 2 0.021
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.021
ribonucleoside monophosphate catabolic process GO:0009158 57 0.021
development of primary sexual characteristics GO:0045137 143 0.020
Worm
nuclear import GO:0051170 95 0.020
multi multicellular organism process GO:0044706 109 0.020
skeletal muscle organ development GO:0060538 163 0.020
regulation of binding GO:0051098 111 0.020
intrinsic apoptotic signaling pathway GO:0097193 132 0.020
placenta development GO:0001890 140 0.020
regulation of mitotic cell cycle GO:0007346 126 0.020
regulation of intracellular transport GO:0032386 159 0.020
pole plasm assembly GO:0007315 2 0.020
oocyte anterior posterior axis specification GO:0007314 2 0.019
regulation of cellular amine metabolic process GO:0033238 20 0.019
chromosome segregation GO:0007059 48 0.019
regulation of intracellular protein transport GO:0033157 82 0.019
regionalization GO:0003002 337 0.019
muscle tissue development GO:0060537 308 0.019
cellular response to lipid GO:0071396 145 0.019
positive regulation of cell development GO:0010720 237 0.018
positive regulation of cell cycle GO:0045787 92 0.018
response to dsrna GO:0043331 30 0.018
cellular response to organonitrogen compound GO:0071417 145 0.018
response to inorganic substance GO:0010035 96 0.018
muscle cell differentiation GO:0042692 261 0.018
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.018
regulation of mitotic cell cycle phase transition GO:1901990 73 0.018
multicellular organism growth GO:0035264 161 0.018
negative regulation of cell cycle GO:0045786 123 0.017
establishment of protein localization to organelle GO:0072594 118 0.017
ribonucleoprotein complex subunit organization GO:0071826 28 0.017
fertilization GO:0009566 127 0.017
trna metabolic process GO:0006399 11 0.017
cellular protein complex assembly GO:0043623 116 0.017
transmembrane transport GO:0055085 412 0.017
regulation of proteolysis GO:0030162 164 0.017
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.017
cell type specific apoptotic process GO:0097285 268 0.017
positive regulation of nervous system development GO:0051962 221 0.017
oogenesis GO:0048477 56 0.017
ossification GO:0001503 216 0.017
ribosomal small subunit biogenesis GO:0042274 4 0.017
rna splicing via transesterification reactions GO:0000375 43 0.017
regulation of hydrolase activity GO:0051336 246 0.017
mesenchyme development GO:0060485 152 0.016
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.016
protein import GO:0017038 101 0.016
epithelial cell proliferation GO:0050673 174 0.016
mesenchymal cell development GO:0014031 93 0.016
negative regulation of phosphate metabolic process GO:0045936 184 0.016
rna localization GO:0006403 23 0.016
mapk cascade GO:0000165 281 0.016
stem cell differentiation GO:0048863 268 0.016
negative regulation of cell development GO:0010721 169 0.016
mesenchymal cell differentiation GO:0048762 107 0.016
regulation of cytoplasmic transport GO:1903649 112 0.016
nucleoside monophosphate catabolic process GO:0009125 59 0.015
establishment or maintenance of cytoskeleton polarity GO:0030952 2 0.015
inflammatory response GO:0006954 244 0.015
positive regulation of protein modification process GO:0031401 299 0.015
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.015
meiotic cell cycle GO:0051321 122 0.015
lipid localization GO:0010876 126 0.015
oocyte axis specification GO:0007309 2 0.015
positive regulation of cellular catabolic process GO:0031331 148 0.015
anatomical structure homeostasis GO:0060249 145 0.014
synaptic transmission GO:0007268 329 0.014
negative regulation of immune system process GO:0002683 209 0.014
regulation of cell cycle process GO:0010564 160 0.014
protein localization to nucleus GO:0034504 121 0.014
maintenance of location GO:0051235 89 0.014
regulation of protein processing GO:0070613 96 0.014
cellular homeostasis GO:0019725 240 0.014
negative regulation of apoptotic signaling pathway GO:2001234 104 0.014
male sex differentiation GO:0046661 109 0.014
protein localization to organelle GO:0033365 185 0.014
positive regulation of intracellular protein transport GO:0090316 42 0.013
protein import into nucleus GO:0006606 95 0.013
cellular response to cytokine stimulus GO:0071345 189 0.013
response to acid chemical GO:0001101 111 0.013
spindle assembly involved in mitosis GO:0090307 4 0.013
action potential GO:0001508 78 0.013
positive regulation of protein phosphorylation GO:0001934 242 0.013
cellular response to inorganic substance GO:0071241 37 0.013
regulation of intrinsic apoptotic signaling pathway GO:2001242 61 0.013
ubiquitin dependent protein catabolic process GO:0006511 129 0.013
small gtpase mediated signal transduction GO:0007264 97 0.013
regulation of protein maturation GO:1903317 96 0.013
g1 s transition of mitotic cell cycle GO:0000082 57 0.013
oocyte development GO:0048599 33 0.013
olfactory learning GO:0008355 2 0.012
axonogenesis GO:0007409 274 0.012
development of primary male sexual characteristics GO:0046546 88 0.012
female gamete generation GO:0007292 74 0.012
cell cycle g1 s phase transition GO:0044843 57 0.012
cell adhesion GO:0007155 329 0.012
adult locomotory behavior GO:0008344 91 0.012
double strand break repair GO:0006302 48 0.012
organelle localization GO:0051640 179 0.012
regulation of cellular ketone metabolic process GO:0010565 66 0.012
response to light stimulus GO:0009416 135 0.012
regulation of establishment of protein localization GO:0070201 181 0.012
regulation of defense response GO:0031347 233 0.012
dna packaging GO:0006323 30 0.012
genitalia development GO:0048806 37 0.012
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 56 0.012
skeletal system development GO:0001501 356 0.012
mitochondrion organization GO:0007005 134 0.011
histone acetylation GO:0016573 41 0.011
response to radiation GO:0009314 165 0.011
peptidyl amino acid modification GO:0018193 336 0.011
Human
membrane organization GO:0061024 245 0.011
positive regulation of dna templated transcription elongation GO:0032786 2 0.011
regulation of protein transport GO:0051223 163 0.011
regulation of cell activation GO:0050865 289 0.011
dna geometric change GO:0032392 7 0.011
neuron death GO:0070997 154 0.011
regulation of chromatin modification GO:1903308 57 0.011
protein alkylation GO:0008213 81 0.011
cellular response to growth factor stimulus GO:0071363 197 0.011
gonad development GO:0008406 141 0.011
Worm
small molecule biosynthetic process GO:0044283 132 0.011
multicellular organismal homeostasis GO:0048871 164 0.011
negative regulation of mitotic cell cycle GO:0045930 58 0.011
regulation of rna polymerase ii transcriptional preinitiation complex assembly GO:0045898 2 0.011
cellular response to oxidative stress GO:0034599 76 0.011
ribonucleoprotein complex disassembly GO:0032988 3 0.011
actin cytoskeleton organization GO:0030036 220 0.011
protein methylation GO:0006479 81 0.010
spliceosomal complex disassembly GO:0000390 1 0.010
male gonad development GO:0008584 88 0.010
regulation of system process GO:0044057 200 0.010
regulation of response to wounding GO:1903034 189 0.010
single fertilization GO:0007338 82 0.010
multicellular organismal signaling GO:0035637 91 0.010
forebrain development GO:0030900 302 0.010
negative regulation of proteolysis GO:0045861 74 0.010
regulation of mapk cascade GO:0043408 248 0.010
protein modification by small protein removal GO:0070646 21 0.010
connective tissue development GO:0061448 179 0.010

Metap2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.030
nervous system disease DOID:863 0 0.030
cancer DOID:162 0 0.017
disease of cellular proliferation DOID:14566 0 0.017
organ system cancer DOID:0050686 0 0.017
musculoskeletal system disease DOID:17 0 0.016
central nervous system disease DOID:331 0 0.014
neurodegenerative disease DOID:1289 0 0.010