Mus musculus

130 known processes

Mkl1

MKL (megakaryoblastic leukemia)/myocardin-like 1

(Aliases: AMKL,AW821984,AI852829,Bsac,AW743281,Mrtf-A,Mal)

Mkl1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
ras protein signal transduction GO:0007265 77 0.576
purine ribonucleotide metabolic process GO:0009150 290 0.470
positive regulation of gtp catabolic process GO:0033126 85 0.453
nucleoside metabolic process GO:0009116 246 0.452
peptidyl amino acid modification GO:0018193 336 0.405
Mouse
regulation of purine nucleotide catabolic process GO:0033121 122 0.399
ribose phosphate metabolic process GO:0019693 291 0.391
nucleoside catabolic process GO:0009164 206 0.370
positive regulation of nucleoside metabolic process GO:0045979 91 0.364
positive regulation of gtpase activity GO:0043547 85 0.363
nucleobase containing small molecule metabolic process GO:0055086 352 0.361
regulation of nucleoside metabolic process GO:0009118 130 0.347
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.336
ribonucleoside metabolic process GO:0009119 245 0.304
purine nucleoside triphosphate metabolic process GO:0009144 226 0.295
regulation of cellular amine metabolic process GO:0033238 20 0.280
gtp catabolic process GO:0006184 143 0.267
regulation of hydrolase activity GO:0051336 246 0.260
guanosine containing compound catabolic process GO:1901069 144 0.244
nucleoside phosphate metabolic process GO:0006753 338 0.240
carbohydrate derivative catabolic process GO:1901136 231 0.238
purine containing compound metabolic process GO:0072521 311 0.235
organonitrogen compound catabolic process GO:1901565 264 0.233
male gamete generation GO:0048232 285 0.217
guanosine containing compound metabolic process GO:1901068 144 0.212
ribonucleoside catabolic process GO:0042454 206 0.208
purine nucleotide metabolic process GO:0006163 302 0.205
glycosyl compound metabolic process GO:1901657 246 0.200
purine nucleoside triphosphate catabolic process GO:0009146 203 0.197
small gtpase mediated signal transduction GO:0007264 97 0.194
purine nucleotide catabolic process GO:0006195 211 0.192
regulation of gtp catabolic process GO:0033124 113 0.189
aromatic compound catabolic process GO:0019439 286 0.182
nucleoside triphosphate metabolic process GO:0009141 230 0.179
striated muscle cell development GO:0055002 125 0.179
Mouse
glycosyl compound catabolic process GO:1901658 206 0.166
muscle cell development GO:0055001 133 0.164
Mouse
purine nucleoside catabolic process GO:0006152 205 0.159
cellular nitrogen compound catabolic process GO:0044270 280 0.150
purine ribonucleoside catabolic process GO:0046130 205 0.148
actin cytoskeleton organization GO:0030036 220 0.147
Fly
ribonucleotide metabolic process GO:0009259 291 0.144
ribonucleotide catabolic process GO:0009261 208 0.142
regulation of clathrin mediated endocytosis GO:2000369 4 0.140
muscle cell differentiation GO:0042692 261 0.135
Human Mouse
cellular ketone metabolic process GO:0042180 84 0.134
nucleotide metabolic process GO:0009117 332 0.129
peptidyl lysine modification GO:0018205 77 0.128
Mouse
organic cyclic compound catabolic process GO:1901361 295 0.127
cellular amine metabolic process GO:0044106 44 0.127
muscle tissue development GO:0060537 308 0.125
Mouse
negative regulation of molecular function GO:0044092 258 0.122
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.117
purine nucleoside metabolic process GO:0042278 241 0.115
ribonucleoside triphosphate metabolic process GO:0009199 220 0.114
asymmetric neuroblast division GO:0055059 1 0.114
nucleotide catabolic process GO:0009166 217 0.111
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.110
nucleoside triphosphate catabolic process GO:0009143 205 0.109
cellular amino acid metabolic process GO:0006520 103 0.109
purine containing compound catabolic process GO:0072523 213 0.108
myotube differentiation GO:0014902 105 0.107
Mouse
heterocycle catabolic process GO:0046700 280 0.107
organophosphate catabolic process GO:0046434 232 0.107
regulation of ras gtpase activity GO:0032318 88 0.107
nucleoside phosphate catabolic process GO:1901292 222 0.106
negative regulation of phosphorylation GO:0042326 166 0.104
peptidyl serine modification GO:0018209 83 0.101
regulation of purine nucleotide metabolic process GO:1900542 169 0.100
membrane organization GO:0061024 245 0.097
rho protein signal transduction GO:0007266 32 0.096
ribonucleoside triphosphate catabolic process GO:0009203 199 0.096
positive regulation of purine nucleotide catabolic process GO:0033123 88 0.096
chromatin modification GO:0016568 187 0.095
Mouse
protein modification by small protein conjugation or removal GO:0070647 207 0.094
mapk cascade GO:0000165 281 0.094
protein localization to membrane GO:0072657 108 0.093
histone modification GO:0016570 159 0.093
Mouse
gtp metabolic process GO:0046039 144 0.091
muscle contraction GO:0006936 101 0.088
internal peptidyl lysine acetylation GO:0018393 42 0.088
Mouse
cell adhesion GO:0007155 329 0.088
mitotic cell cycle GO:0000278 195 0.086
regulation of cellular ketone metabolic process GO:0010565 66 0.086
purine ribonucleotide catabolic process GO:0009154 208 0.085
regulation of organelle organization GO:0033043 289 0.085
Mouse
transmembrane transport GO:0055085 412 0.081
positive regulation of cellular catabolic process GO:0031331 148 0.080
positive regulation of rab gtpase activity GO:0032851 7 0.078
regulation of cellular amino acid metabolic process GO:0006521 5 0.077
response to organonitrogen compound GO:0010243 246 0.077
amine metabolic process GO:0009308 45 0.075
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.075
positive regulation of cell projection organization GO:0031346 95 0.074
renal system development GO:0072001 225 0.073
Mouse
regulation of insulin receptor signaling pathway GO:0046626 21 0.071
regulation of nucleotide metabolic process GO:0006140 169 0.069
photoreceptor cell morphogenesis GO:0008594 3 0.068
cell substrate adhesion GO:0031589 130 0.068
histone acetylation GO:0016573 41 0.065
Mouse
positive regulation of protein modification process GO:0031401 299 0.065
cellular response to organonitrogen compound GO:0071417 145 0.064
negative regulation of protein phosphorylation GO:0001933 126 0.064
locomotory behavior GO:0007626 195 0.063
post embryonic retina morphogenesis in camera type eye GO:0060060 3 0.060
divalent inorganic cation transport GO:0072511 178 0.060
muscle fiber development GO:0048747 76 0.060
Mouse
myeloid cell differentiation GO:0030099 233 0.059
actin filament organization GO:0007015 113 0.059
purine ribonucleoside metabolic process GO:0046128 241 0.059
activation of immune response GO:0002253 138 0.058
intracellular protein transport GO:0006886 204 0.058
cell junction organization GO:0034330 77 0.058
peptidyl serine phosphorylation GO:0018105 74 0.057
spermatogenesis GO:0007283 284 0.057
macromolecule catabolic process GO:0009057 281 0.057
cell fate commitment GO:0045165 210 0.055
erk1 and erk2 cascade GO:0070371 77 0.055
protein localization to organelle GO:0033365 185 0.055
cell division GO:0051301 120 0.053
Fly
actin filament bundle assembly GO:0051017 40 0.053
synaptic transmission GO:0007268 329 0.053
protein catabolic process GO:0030163 221 0.053
negative regulation of intracellular signal transduction GO:1902532 167 0.053
endocytosis GO:0006897 168 0.053
cardiac muscle cell differentiation GO:0055007 69 0.053
Mouse
endomembrane system organization GO:0010256 147 0.052
regulation of myeloid cell differentiation GO:0045637 96 0.052
regulation of nucleotide catabolic process GO:0030811 122 0.052
positive regulation of ras gtpase activity GO:0032320 65 0.051
regulation of kinase activity GO:0043549 249 0.051
cellular response to growth factor stimulus GO:0071363 197 0.051
Mouse
ion transmembrane transport GO:0034220 361 0.049
negative regulation of cellular protein metabolic process GO:0032269 247 0.049
positive regulation of nucleotide metabolic process GO:0045981 114 0.049
negative regulation of phosphorus metabolic process GO:0010563 184 0.049
regulation of rho gtpase activity GO:0032319 58 0.049
peptidyl tyrosine phosphorylation GO:0018108 143 0.048
adherens junction organization GO:0034332 28 0.048
mitotic cytokinesis GO:0000281 4 0.048
adult behavior GO:0030534 135 0.047
homeostasis of number of cells GO:0048872 210 0.047
erythrocyte differentiation GO:0030218 88 0.047
positive regulation of mapk cascade GO:0043410 170 0.046
regulation of vesicle mediated transport GO:0060627 139 0.045
regulation of transferase activity GO:0051338 263 0.045
neural precursor cell proliferation GO:0061351 121 0.045
negative regulation of cellular component organization GO:0051129 194 0.044
positive regulation of hydrolase activity GO:0051345 148 0.044
negative regulation of immune system process GO:0002683 209 0.043
cellular response to insulin stimulus GO:0032869 78 0.043
protein modification by small protein conjugation GO:0032446 187 0.043
positive regulation of protein phosphorylation GO:0001934 242 0.043
positive regulation of cellular amine metabolic process GO:0033240 5 0.042
regulation of protein kinase activity GO:0045859 232 0.042
asymmetric stem cell division GO:0098722 3 0.042
sequestering of metal ion GO:0051238 19 0.042
intra golgi vesicle mediated transport GO:0006891 1 0.041
establishment of protein localization to membrane GO:0090150 54 0.041
cellular ion homeostasis GO:0006873 165 0.041
negative regulation of mapk cascade GO:0043409 65 0.041
second messenger mediated signaling GO:0019932 73 0.041
sequestering of calcium ion GO:0051208 18 0.041
cellular response to peptide GO:1901653 92 0.041
negative regulation of kinase activity GO:0033673 81 0.041
cilium morphogenesis GO:0060271 102 0.041
internal protein amino acid acetylation GO:0006475 42 0.040
Mouse
actin filament polymerization GO:0030041 44 0.040
regulation of mapk cascade GO:0043408 248 0.040
striated muscle tissue development GO:0014706 293 0.040
Mouse
regulation of homeostatic process GO:0032844 182 0.040
inorganic cation transmembrane transport GO:0098662 207 0.039
organelle fission GO:0048285 170 0.039
regulation of cytoplasmic transport GO:1903649 112 0.039
sensory organ morphogenesis GO:0090596 242 0.039
chromatin organization GO:0006325 206 0.038
Mouse
positive regulation of transferase activity GO:0051347 167 0.038
protein autophosphorylation GO:0046777 61 0.038
regulation of cell motility GO:2000145 236 0.038
protein acylation GO:0043543 64 0.037
Mouse
g protein coupled receptor signaling pathway GO:0007186 243 0.037
dephosphorylation GO:0016311 129 0.037
regulation of cellular catabolic process GO:0031329 242 0.036
regulation of lymphocyte activation GO:0051249 240 0.036
regulation of intracellular transport GO:0032386 159 0.036
cellular component assembly involved in morphogenesis GO:0010927 139 0.036
negative regulation of hydrolase activity GO:0051346 71 0.036
establishment or maintenance of cell polarity GO:0007163 86 0.036
cation transmembrane transport GO:0098655 266 0.035
heart process GO:0003015 94 0.035
positive regulation of neuron projection development GO:0010976 79 0.035
cation transport GO:0006812 399 0.035
camera type eye development GO:0043010 266 0.035
positive regulation of nervous system development GO:0051962 221 0.035
blood circulation GO:0008015 195 0.035
cytoplasmic transport GO:0016482 234 0.034
ameboidal type cell migration GO:0001667 128 0.034
Fly
mitotic cell cycle process GO:1903047 159 0.034
positive regulation of nucleotide catabolic process GO:0030813 88 0.034
regulation of neuron projection development GO:0010975 169 0.033
rab protein signal transduction GO:0032482 1 0.033
negative regulation of phosphate metabolic process GO:0045936 184 0.033
regulation of anatomical structure size GO:0090066 178 0.032
regulation of wnt signaling pathway GO:0030111 123 0.032
negative regulation of apoptotic signaling pathway GO:2001234 104 0.032
cell cell junction organization GO:0045216 72 0.032
response to growth factor GO:0070848 198 0.032
Mouse
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.032
phospholipid metabolic process GO:0006644 87 0.031
microtubule based process GO:0007017 236 0.031
positive regulation of binding GO:0051099 49 0.031
Mouse
negative regulation of phagocytosis GO:0050765 4 0.031
cell matrix adhesion GO:0007160 68 0.031
retina development in camera type eye GO:0060041 119 0.030
positive regulation of growth GO:0045927 104 0.030
immune response regulating signaling pathway GO:0002764 125 0.030
inorganic ion transmembrane transport GO:0098660 234 0.030
regulation of cytoskeleton organization GO:0051493 122 0.030
multicellular organismal homeostasis GO:0048871 164 0.029
maintenance of location GO:0051235 89 0.029
calcium ion transport GO:0006816 159 0.029
wnt signaling pathway GO:0016055 188 0.029
lung development GO:0030324 164 0.029
Mouse
macromolecular complex disassembly GO:0032984 43 0.028
hematopoietic progenitor cell differentiation GO:0002244 143 0.028
microtubule based movement GO:0007018 84 0.028
protein localization to plasma membrane GO:0072659 57 0.028
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.028
response to peptide hormone GO:0043434 127 0.028
microtubule cytoskeleton organization GO:0000226 157 0.028
cation homeostasis GO:0055080 212 0.028
regulation of mitotic cell cycle GO:0007346 126 0.028
canonical wnt signaling pathway GO:0060070 130 0.028
regulation of ion transport GO:0043269 215 0.027
myeloid cell homeostasis GO:0002262 114 0.027
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.027
divalent metal ion transport GO:0070838 172 0.027
regulation of receptor activity GO:0010469 41 0.026
covalent chromatin modification GO:0016569 163 0.026
Mouse
negative regulation of homeostatic process GO:0032845 71 0.026
microtubule depolymerization GO:0007019 15 0.026
regulation of neuron differentiation GO:0045664 281 0.026
regulation of histone modification GO:0031056 56 0.026
Mouse
regulation of metal ion transport GO:0010959 106 0.026
regulation of erk1 and erk2 cascade GO:0070372 71 0.026
anatomical structure homeostasis GO:0060249 145 0.026
regulation of transporter activity GO:0032409 57 0.026
negative regulation of protein depolymerization GO:1901880 21 0.026
muscle system process GO:0003012 141 0.025
cilium assembly GO:0042384 81 0.025
regulation of endocytosis GO:0030100 69 0.025
focal adhesion assembly GO:0048041 19 0.025
regulation of binding GO:0051098 111 0.025
Mouse
circulatory system process GO:0003013 197 0.025
positive regulation of kinase activity GO:0033674 155 0.025
organelle localization GO:0051640 179 0.025
cognition GO:0050890 149 0.025
cellular response to peptide hormone stimulus GO:0071375 92 0.025
positive regulation of map kinase activity GO:0043406 84 0.025
negative regulation of cellular amine metabolic process GO:0033239 1 0.025
response to light stimulus GO:0009416 135 0.025
anion transport GO:0006820 177 0.024
positive regulation of dna templated transcription elongation GO:0032786 2 0.024
spermatid differentiation GO:0048515 115 0.024
cellular homeostasis GO:0019725 240 0.024
regulation of map kinase activity GO:0043405 120 0.024
immune effector process GO:0002252 321 0.024
cardiocyte differentiation GO:0035051 87 0.024
Mouse
gonad development GO:0008406 141 0.023
mitotic nuclear division GO:0007067 48 0.023
positive regulation of neuron differentiation GO:0045666 141 0.023
regulation of cell activation GO:0050865 289 0.023
protein targeting to membrane GO:0006612 20 0.023
positive regulation of protein kinase activity GO:0045860 144 0.023
nucleus localization GO:0051647 20 0.023
regulation of chromatin modification GO:1903308 57 0.023
Mouse
regulation of fat cell differentiation GO:0045598 81 0.023
regulation of chromatin organization GO:1902275 57 0.023
Mouse
cellular protein complex assembly GO:0043623 116 0.023
carbohydrate metabolic process GO:0005975 230 0.022
axonogenesis GO:0007409 274 0.022
negative regulation of camp mediated signaling GO:0043951 3 0.022
negative regulation of triglyceride metabolic process GO:0090209 4 0.022
regulation of protein serine threonine kinase activity GO:0071900 157 0.022
regulation of protein binding GO:0043393 60 0.022
protein ubiquitination GO:0016567 171 0.022
organelle assembly GO:0070925 177 0.022
establishment of protein localization to organelle GO:0072594 118 0.022
meiotic cell cycle process GO:1903046 77 0.022
spermatid development GO:0007286 108 0.022
negative regulation of protein metabolic process GO:0051248 282 0.021
establishment of protein localization to plasma membrane GO:0090002 34 0.021
positive regulation of actin nucleation GO:0051127 3 0.021
negative regulation of protein modification process GO:0031400 163 0.021
cell growth GO:0016049 130 0.021
Mouse
early endosome to late endosome transport GO:0045022 2 0.021
multicellular organism growth GO:0035264 161 0.021
positive regulation of rho gtpase activity GO:0032321 41 0.021
peptidyl lysine acetylation GO:0018394 45 0.021
Mouse
regulation of protein complex disassembly GO:0043244 28 0.021
lymphocyte differentiation GO:0030098 242 0.021
cellular chemical homeostasis GO:0055082 215 0.021
blood vessel morphogenesis GO:0048514 285 0.021
Mouse
regulation of transmembrane transport GO:0034762 128 0.021
negative regulation of organelle organization GO:0010639 90 0.021
memory GO:0007613 58 0.021
positive regulation of cytoskeleton organization GO:0051495 49 0.021
cell fate determination GO:0001709 32 0.021
regulation of cytokine production GO:0001817 266 0.020
tissue remodeling GO:0048771 102 0.020
cytokine production GO:0001816 319 0.020
tissue homeostasis GO:0001894 115 0.020
negative regulation of cytokine production GO:0001818 84 0.020
actin polymerization or depolymerization GO:0008154 54 0.020
mesoderm development GO:0007498 100 0.020
Fly
metal ion homeostasis GO:0055065 189 0.020
defecation GO:0030421 1 0.020
positive regulation of organelle organization GO:0010638 128 0.020
respiratory tube development GO:0030323 167 0.020
Mouse
adherens junction assembly GO:0034333 22 0.020
regulation of cell cycle GO:0051726 281 0.020
clathrin mediated endocytosis GO:0072583 7 0.020
compound eye development GO:0048749 1 0.020
nuclear division GO:0000280 158 0.020
negative adaptation of signaling pathway GO:0022401 5 0.019
microtubule cytoskeleton organization involved in mitosis GO:1902850 4 0.019
negative regulation of g protein coupled receptor protein signaling pathway GO:0045744 12 0.019
glucose metabolic process GO:0006006 92 0.019
protein maturation GO:0051604 176 0.019
regulation of actin polymerization or depolymerization GO:0008064 45 0.019
bone resorption GO:0045453 38 0.019
regulation of ral protein signal transduction GO:0032485 4 0.019
positive regulation of rac gtpase activity GO:0032855 14 0.019
peptidyl tyrosine modification GO:0018212 145 0.019
hexose metabolic process GO:0019318 98 0.019
modification dependent macromolecule catabolic process GO:0043632 133 0.019
regulation of ion homeostasis GO:2000021 64 0.019
regulation of ion transmembrane transport GO:0034765 119 0.019
rac protein signal transduction GO:0016601 13 0.018
cartilage development GO:0051216 140 0.018
meiotic cell cycle GO:0051321 122 0.018
regulation of protein processing GO:0070613 96 0.018
apoptotic signaling pathway GO:0097190 306 0.018
regulation of actin nucleation GO:0051125 4 0.018
learning or memory GO:0007611 148 0.018
response to peptide GO:1901652 136 0.018
leukocyte differentiation GO:0002521 342 0.018
cellularization GO:0007349 1 0.018
respiratory system development GO:0060541 190 0.018
Mouse Fly
digestive tract development GO:0048565 190 0.018
Mouse Fly
response to organic cyclic compound GO:0014070 198 0.018
positive regulation of creb transcription factor activity GO:0032793 4 0.017
divalent inorganic cation homeostasis GO:0072507 138 0.017
regulation of cell adhesion GO:0030155 154 0.017
regulation of chromosome organization GO:0033044 83 0.017
Mouse
nitrogen compound transport GO:0071705 271 0.017
positive regulation of cell development GO:0010720 237 0.017
protein import into nucleus GO:0006606 95 0.017
regulation of cell projection organization GO:0031344 206 0.017
regulation of lamellipodium assembly GO:0010591 3 0.017
regulation of cell cycle process GO:0010564 160 0.017
protein processing GO:0016485 163 0.017
regulation of peptidyl tyrosine phosphorylation GO:0050730 93 0.017
regulation of notch signaling pathway GO:0008593 35 0.017
negative regulation of microtubule polymerization or depolymerization GO:0031111 15 0.017
regulation of system process GO:0044057 200 0.017
cellular protein catabolic process GO:0044257 155 0.017
cardiac muscle tissue development GO:0048738 130 0.017
Mouse
golgi vesicle transport GO:0048193 30 0.017
regulation of leukocyte differentiation GO:1902105 159 0.016
regulation of protein localization GO:0032880 231 0.016
regulation of calcium ion transport GO:0051924 69 0.016
regulation of toll signaling pathway GO:0008592 1 0.016
fat cell differentiation GO:0045444 160 0.016
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.016
positive regulation of cellular component biogenesis GO:0044089 94 0.016
activation of mapk activity GO:0000187 59 0.016
retrograde transport endosome to golgi GO:0042147 2 0.016
epithelial cell development GO:0002064 159 0.016
Fly
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 40 0.016
cellular response to cytokine stimulus GO:0071345 189 0.016
regulation of blood circulation GO:1903522 93 0.016
transmission of nerve impulse GO:0019226 76 0.016
regulation of g protein coupled receptor protein signaling pathway GO:0008277 37 0.016
cell substrate adherens junction assembly GO:0007045 19 0.016
positive regulation of transcription elongation from rna polymerase ii promoter GO:0032968 2 0.016
calcium ion transport into cytosol GO:0060402 48 0.016
regulation of carbohydrate metabolic process GO:0006109 75 0.016
negative regulation of transferase activity GO:0051348 85 0.016
negative regulation of defense response GO:0031348 77 0.016
g protein coupled receptor internalization GO:0002031 3 0.015
adult locomotory behavior GO:0008344 91 0.015
protein polymerization GO:0051258 57 0.015
protein oligomerization GO:0051259 67 0.015
circadian rhythm GO:0007623 114 0.015
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.015
negative regulation of endopeptidase activity GO:0010951 44 0.015
regulation of cell projection assembly GO:0060491 38 0.015
interleukin 6 production GO:0032635 58 0.015
skeletal system development GO:0001501 356 0.015
cellular response to hormone stimulus GO:0032870 150 0.015
neutral lipid biosynthetic process GO:0046460 18 0.015
skin development GO:0043588 220 0.015
protein desumoylation GO:0016926 2 0.015
negative regulation of protein maturation GO:1903318 79 0.015
regulation of protein complex assembly GO:0043254 83 0.015
regulation of cellular component biogenesis GO:0044087 181 0.014
plasma membrane organization GO:0007009 90 0.014
microtubule based transport GO:0010970 50 0.014
bone remodeling GO:0046849 53 0.014
regulation of heart contraction GO:0008016 77 0.014
epidermis development GO:0008544 187 0.014
kidney development GO:0001822 213 0.014
skeletal system morphogenesis GO:0048705 203 0.014
negative regulation of triglyceride biosynthetic process GO:0010868 2 0.014
regulation of striated muscle cell differentiation GO:0051153 81 0.014
Mouse
posttranscriptional regulation of gene expression GO:0010608 155 0.014
bone development GO:0060348 120 0.014
negative regulation of cell development GO:0010721 169 0.014
ubiquitin dependent protein catabolic process GO:0006511 129 0.014
nuclear transport GO:0051169 139 0.014
regulation of cell migration GO:0030334 219 0.014
monosaccharide metabolic process GO:0005996 106 0.014
tissue migration GO:0090130 68 0.014
Fly
activation of innate immune response GO:0002218 56 0.014
insulin receptor signaling pathway GO:0008286 49 0.014
regulation of microtubule depolymerization GO:0031114 13 0.014
regulation of apoptotic signaling pathway GO:2001233 197 0.014
meiosis i GO:0007127 60 0.014
t cell differentiation GO:0030217 174 0.014
primary neural tube formation GO:0014020 95 0.014
chemotaxis GO:0006935 247 0.013
modification dependent protein catabolic process GO:0019941 133 0.013
ectodermal cell differentiation GO:0010668 3 0.013
protein targeting GO:0006605 143 0.013
regulation of cell growth GO:0001558 91 0.013
Mouse
jak stat cascade GO:0007259 42 0.013
regulation of muscle contraction GO:0006937 49 0.013
glycerolipid metabolic process GO:0046486 122 0.013
meiotic nuclear division GO:0007126 115 0.013
retina morphogenesis in camera type eye GO:0060042 45 0.013
negative regulation of cytoskeleton organization GO:0051494 36 0.013
regulation of rho protein signal transduction GO:0035023 71 0.013
palate development GO:0060021 76 0.013
regulation of actin filament polymerization GO:0030833 38 0.013
desensitization of g protein coupled receptor protein signaling pathway GO:0002029 5 0.013
cellular macromolecule catabolic process GO:0044265 206 0.013
sarcomere organization GO:0045214 24 0.013
megakaryocyte differentiation GO:0030219 26 0.013
negative regulation of proteolysis GO:0045861 74 0.013
activation of rac gtpase activity GO:0032863 2 0.013
receptor mediated endocytosis GO:0006898 51 0.013
cellular divalent inorganic cation homeostasis GO:0072503 127 0.013
digestive system development GO:0055123 200 0.012
Mouse Fly
hexose biosynthetic process GO:0019319 39 0.012
limb morphogenesis GO:0035108 149 0.012
regulation of ras protein signal transduction GO:0046578 114 0.012
dna metabolic process GO:0006259 303 0.012
multicellular organismal signaling GO:0035637 91 0.012
positive regulation of cytosolic calcium ion concentration GO:0007204 65 0.012
negative regulation of cell proliferation GO:0008285 296 0.012
regulation of cell division GO:0051302 76 0.012
Fly
negative regulation of toll signaling pathway GO:0045751 1 0.012
positive regulation of striated muscle contraction GO:0045989 3 0.012
regulation of defense response GO:0031347 233 0.012
neuron projection guidance GO:0097485 141 0.012
regulation of t cell activation GO:0050863 170 0.012
actin filament based movement GO:0030048 23 0.012
protein alkylation GO:0008213 81 0.012
heart contraction GO:0060047 93 0.012
positive regulation of myeloid cell differentiation GO:0045639 43 0.012
calcium ion homeostasis GO:0055074 127 0.012
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.012
Mouse
immune response activating signal transduction GO:0002757 116 0.012
cellular protein complex disassembly GO:0043624 36 0.012
photoreceptor cell differentiation GO:0046530 52 0.012
regulation of membrane potential GO:0042391 192 0.012
cellular metal ion homeostasis GO:0006875 151 0.012
positive regulation of actin filament polymerization GO:0030838 26 0.012
neuron projection extension GO:1990138 64 0.012
mesodermal cell migration GO:0008078 4 0.012
Fly
neuron migration GO:0001764 122 0.012
single organismal cell cell adhesion GO:0016337 131 0.012
innate immune response GO:0045087 157 0.012
epidermal growth factor receptor signaling pathway via i kappab kinase nf kappab cascade GO:0038168 1 0.012
regulation of cellular component size GO:0032535 121 0.012
cytoskeleton dependent intracellular transport GO:0030705 50 0.011
negative regulation of protein processing GO:0010955 79 0.011
regulation of interleukin 12 production GO:0032655 30 0.011
endochondral bone morphogenesis GO:0060350 50 0.011
epithelium migration GO:0090132 63 0.011
Fly
sensory system development GO:0048880 3 0.011

Mkl1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.019
nervous system disease DOID:863 0 0.019
musculoskeletal system disease DOID:17 0 0.016
sensory system disease DOID:0050155 0 0.012