Mus musculus

14 known processes

Mpl

myeloproliferative leukemia virus oncogene

(Aliases: hlb219,CD110,c-mpl,TPO-R,c-mpl-I,c-mpl-II)

Mpl biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
leukocyte differentiation GO:0002521 342 0.727
Mouse
cation homeostasis GO:0055080 212 0.672
inflammatory response GO:0006954 244 0.671
cell adhesion GO:0007155 329 0.656
t cell differentiation GO:0030217 174 0.589
Mouse
regulation of defense response GO:0031347 233 0.559
blood coagulation GO:0007596 76 0.545
metal ion homeostasis GO:0055065 189 0.537
leukocyte mediated immunity GO:0002443 174 0.501
Mouse
immune effector process GO:0002252 321 0.500
Mouse
regulation of cellular amine metabolic process GO:0033238 20 0.453
stem cell differentiation GO:0048863 268 0.431
regulation of cytokine production GO:0001817 266 0.412
lymphocyte differentiation GO:0030098 242 0.374
Mouse
cellular metal ion homeostasis GO:0006875 151 0.358
positive regulation of lymphocyte activation GO:0051251 140 0.353
Mouse
cellular amine metabolic process GO:0044106 44 0.343
actin cytoskeleton organization GO:0030036 220 0.340
single organismal cell cell adhesion GO:0016337 131 0.339
hemostasis GO:0007599 78 0.333
cell chemotaxis GO:0060326 81 0.320
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.311
Mouse
divalent inorganic cation homeostasis GO:0072507 138 0.282
regulation of multi organism process GO:0043900 111 0.276
wound healing GO:0042060 157 0.272
cellular divalent inorganic cation homeostasis GO:0072503 127 0.270
sensory organ morphogenesis GO:0090596 242 0.270
calcium ion homeostasis GO:0055074 127 0.262
regulation of cell motility GO:2000145 236 0.261
regulation of body fluid levels GO:0050878 162 0.260
regulation of homeostatic process GO:0032844 182 0.254
cellular response to hormone stimulus GO:0032870 150 0.254
circulatory system process GO:0003013 197 0.250
t cell activation GO:0042110 289 0.242
Mouse
regulation of inflammatory response GO:0050727 147 0.239
regulation of cellular ketone metabolic process GO:0010565 66 0.237
cellular ion homeostasis GO:0006873 165 0.228
regulation of lymphocyte activation GO:0051249 240 0.227
Mouse
cellular chemical homeostasis GO:0055082 215 0.224
regulation of response to wounding GO:1903034 189 0.223
positive regulation of leukocyte differentiation GO:1902107 86 0.222
Mouse
positive regulation of protein phosphorylation GO:0001934 242 0.219
eosinophil migration GO:0072677 3 0.212
leukocyte migration GO:0050900 124 0.207
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.206
positive regulation of cytosolic calcium ion concentration GO:0007204 65 0.206
gliogenesis GO:0042063 141 0.205
cellular potassium ion transport GO:0071804 43 0.201
small molecule biosynthetic process GO:0044283 132 0.200
regulation of transferase activity GO:0051338 263 0.196
cell fate commitment GO:0045165 210 0.192
regulation of leukocyte differentiation GO:1902105 159 0.190
Mouse
epithelial tube morphogenesis GO:0060562 303 0.189
leukocyte proliferation GO:0070661 172 0.189
Mouse
amine metabolic process GO:0009308 45 0.188
blood circulation GO:0008015 195 0.183
regulation of adaptive immune response GO:0002819 90 0.180
Mouse
lymphocyte migration GO:0072676 26 0.177
neuron projection guidance GO:0097485 141 0.177
coagulation GO:0050817 78 0.173
negative regulation of cytokine production GO:0001818 84 0.173
adaptive immune response GO:0002250 155 0.172
Mouse
chemotaxis GO:0006935 247 0.167
defense response to other organism GO:0098542 197 0.166
cellular calcium ion homeostasis GO:0006874 119 0.164
positive regulation of protein kinase activity GO:0045860 144 0.162
cellular homeostasis GO:0019725 240 0.158
ossification GO:0001503 216 0.155
carbohydrate derivative biosynthetic process GO:1901137 183 0.153
transmembrane transport GO:0055085 412 0.151
regulation of t cell activation GO:0050863 170 0.151
Mouse
b cell activation GO:0042113 161 0.150
Mouse
protein secretion GO:0009306 111 0.148
cation transport GO:0006812 399 0.141
positive regulation of camp mediated signaling GO:0043950 3 0.141
homeostasis of number of cells GO:0048872 210 0.136
leukocyte homeostasis GO:0001776 79 0.135
positive regulation of inflammatory response GO:0050729 47 0.132
myeloid cell homeostasis GO:0002262 114 0.131
organophosphate biosynthetic process GO:0090407 122 0.131
production of molecular mediator of immune response GO:0002440 103 0.129
Mouse
response to organonitrogen compound GO:0010243 246 0.128
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 87 0.125
Mouse
glial cell differentiation GO:0010001 131 0.122
lymphocyte mediated immunity GO:0002449 139 0.121
Mouse
positive regulation of cell activation GO:0050867 158 0.120
Mouse
muscle contraction GO:0006936 101 0.119
regulation of leukocyte proliferation GO:0070663 121 0.118
myeloid leukocyte differentiation GO:0002573 119 0.118
response to radiation GO:0009314 165 0.118
acute inflammatory response GO:0002526 41 0.117
cation transmembrane transport GO:0098655 266 0.116
cell type specific apoptotic process GO:0097285 268 0.116
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.116
germ cell development GO:0007281 185 0.116
circadian rhythm GO:0007623 114 0.116
negative regulation of immune system process GO:0002683 209 0.116
Mouse
activation of immune response GO:0002253 138 0.115
negative regulation of cell proliferation GO:0008285 296 0.115
regulation of cellular amino acid metabolic process GO:0006521 5 0.114
organic hydroxy compound biosynthetic process GO:1901617 77 0.113
urogenital system development GO:0001655 261 0.113
cell activation involved in immune response GO:0002263 126 0.112
embryonic organ morphogenesis GO:0048562 276 0.111
response to growth factor GO:0070848 198 0.111
regulation of cell migration GO:0030334 219 0.111
regulation of leukocyte mediated immunity GO:0002703 104 0.110
Mouse
positive regulation of t cell differentiation GO:0045582 52 0.110
Mouse
cellular ketone metabolic process GO:0042180 84 0.109
t cell proliferation GO:0042098 120 0.108
alpha beta t cell differentiation GO:0046632 69 0.108
cytokine production GO:0001816 319 0.107
forebrain neuron differentiation GO:0021879 52 0.107
regulation of actin cytoskeleton organization GO:0032956 84 0.107
response to acid chemical GO:0001101 111 0.107
organic hydroxy compound metabolic process GO:1901615 203 0.105
multicellular organism growth GO:0035264 161 0.102
positive regulation of cell motility GO:2000147 116 0.102
positive regulation of protein modification process GO:0031401 299 0.102
regulation of anatomical structure size GO:0090066 178 0.102
Mouse
b cell proliferation GO:0042100 53 0.101
Mouse
leukocyte activation involved in immune response GO:0002366 126 0.101
regulation of b cell proliferation GO:0030888 39 0.100
kidney development GO:0001822 213 0.098
glycoprotein biosynthetic process GO:0009101 89 0.097
mapk cascade GO:0000165 281 0.095
actomyosin structure organization GO:0031032 56 0.094
tissue homeostasis GO:0001894 115 0.094
actin filament organization GO:0007015 113 0.093
stem cell development GO:0048864 219 0.093
negative regulation of protein metabolic process GO:0051248 282 0.093
regulation of lymphocyte proliferation GO:0050670 117 0.092
t cell differentiation in thymus GO:0033077 77 0.092
Mouse
regulation of map kinase activity GO:0043405 120 0.091
alpha beta t cell activation GO:0046631 91 0.091
b cell differentiation GO:0030183 78 0.090
regulation of organelle organization GO:0033043 289 0.090
positive regulation of defense response GO:0031349 124 0.089
positive regulation of leukocyte proliferation GO:0070665 73 0.088
epithelial to mesenchymal transition GO:0001837 47 0.087
immune response regulating signaling pathway GO:0002764 125 0.087
leukocyte chemotaxis GO:0030595 69 0.086
endocrine system development GO:0035270 98 0.086
regulation of coagulation GO:0050818 31 0.085
cytosolic calcium ion homeostasis GO:0051480 70 0.085
covalent chromatin modification GO:0016569 163 0.084
glycoprotein metabolic process GO:0009100 116 0.084
cytokine secretion GO:0050663 72 0.084
multi multicellular organism process GO:0044706 109 0.083
Mouse
single organism cell adhesion GO:0098602 156 0.083
regulation of ion transport GO:0043269 215 0.083
regulation of cell activation GO:0050865 289 0.083
Mouse
regulation of mapk cascade GO:0043408 248 0.081
negative regulation of phosphorus metabolic process GO:0010563 184 0.081
organonitrogen compound biosynthetic process GO:1901566 192 0.081
anion transport GO:0006820 177 0.080
positive regulation of homeostatic process GO:0032846 64 0.080
muscle system process GO:0003012 141 0.079
dna metabolic process GO:0006259 303 0.079
forebrain generation of neurons GO:0021872 63 0.078
negative regulation of prostatic bud formation GO:0060686 4 0.078
positive regulation of lymphocyte proliferation GO:0050671 70 0.078
negative regulation of reproductive process GO:2000242 31 0.078
anatomical structure homeostasis GO:0060249 145 0.077
regulation of protein serine threonine kinase activity GO:0071900 157 0.077
striated muscle tissue development GO:0014706 293 0.076
positive regulation of transferase activity GO:0051347 167 0.076
negative regulation of molecular function GO:0044092 258 0.076
regulation of establishment of protein localization GO:0070201 181 0.076
nitrogen compound transport GO:0071705 271 0.076
regulation of ossification GO:0030278 112 0.075
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.075
regulation of membrane potential GO:0042391 192 0.074
regulation of production of molecular mediator of immune response GO:0002700 65 0.074
regulation of protein kinase activity GO:0045859 232 0.073
purine containing compound biosynthetic process GO:0072522 70 0.073
regulation of cell cycle GO:0051726 281 0.072
forebrain development GO:0030900 302 0.072
symbiosis encompassing mutualism through parasitism GO:0044403 83 0.071
negative regulation of nervous system development GO:0051961 156 0.071
nucleoside phosphate biosynthetic process GO:1901293 79 0.070
fertilization GO:0009566 127 0.070
regulation of transmembrane transport GO:0034762 128 0.069
cellular response to peptide GO:1901653 92 0.069
histone modification GO:0016570 159 0.069
heart morphogenesis GO:0003007 178 0.069
embryonic placenta development GO:0001892 98 0.069
male gamete generation GO:0048232 285 0.068
somatotropin secreting cell differentiation GO:0060126 4 0.068
apoptotic signaling pathway GO:0097190 306 0.068
skeletal muscle organ development GO:0060538 163 0.068
organic acid biosynthetic process GO:0016053 86 0.068
adult behavior GO:0030534 135 0.067
regionalization GO:0003002 337 0.067
regulation of cell adhesion GO:0030155 154 0.066
lymphocyte homeostasis GO:0002260 64 0.066
platelet activation GO:0030168 40 0.066
prevention of polyspermy GO:0060468 4 0.066
bone development GO:0060348 120 0.066
nucleoside phosphate metabolic process GO:0006753 338 0.065
negative regulation of inflammatory response GO:0050728 61 0.065
regulation of leukocyte apoptotic process GO:2000106 56 0.065
organelle assembly GO:0070925 177 0.064
negative regulation of intracellular signal transduction GO:1902532 167 0.064
defense response to nematode GO:0002215 4 0.063
neuronal action potential GO:0019228 54 0.063
nucleobase containing small molecule metabolic process GO:0055086 352 0.063
positive regulation of map kinase activity GO:0043406 84 0.062
cell substrate adhesion GO:0031589 130 0.062
exocrine system development GO:0035272 45 0.061
negative regulation of multi organism process GO:0043901 68 0.061
negative regulation of response to wounding GO:1903035 77 0.061
cellular response to insulin stimulus GO:0032869 78 0.060
lymphocyte proliferation GO:0046651 164 0.060
Mouse
intracellular receptor signaling pathway GO:0030522 74 0.059
negative regulation of defense response GO:0031348 77 0.059
positive regulation of immune effector process GO:0002699 107 0.059
leukocyte apoptotic process GO:0071887 71 0.059
cell cell recognition GO:0009988 44 0.059
androgen biosynthetic process GO:0006702 4 0.059
regulation of ion transmembrane transport GO:0034765 119 0.058
ribose phosphate biosynthetic process GO:0046390 59 0.058
positive regulation of lymphocyte migration GO:2000403 11 0.058
columnar cuboidal epithelial cell differentiation GO:0002065 82 0.058
myeloid leukocyte migration GO:0097529 57 0.057
glial cell development GO:0021782 54 0.057
divalent metal ion transport GO:0070838 172 0.057
positive regulation of cell adhesion GO:0045785 80 0.057
cell cell adhesion GO:0098609 41 0.057
protein processing GO:0016485 163 0.056
regulation of acute inflammatory response GO:0002673 27 0.056
negative regulation of feeding behavior GO:2000252 1 0.056
neutrophil migration GO:1990266 37 0.056
b cell mediated immunity GO:0019724 71 0.056
multicellular organismal homeostasis GO:0048871 164 0.056
cellular response to organonitrogen compound GO:0071417 145 0.055
midgut development GO:0007494 4 0.054
lymphocyte activation involved in immune response GO:0002285 93 0.054
regulation of stem cell differentiation GO:2000736 50 0.054
myeloid cell differentiation GO:0030099 233 0.053
cytokine metabolic process GO:0042107 71 0.053
inorganic ion transmembrane transport GO:0098660 234 0.053
positive regulation of mapk cascade GO:0043410 170 0.053
morphogenesis of a branching epithelium GO:0061138 193 0.053
cellular response to cytokine stimulus GO:0071345 189 0.053
macromolecule catabolic process GO:0009057 281 0.053
response to transforming growth factor beta GO:0071559 88 0.053
ribose phosphate metabolic process GO:0019693 291 0.052
catecholamine secretion GO:0050432 15 0.052
regulation of actin filament based process GO:0032970 99 0.051
regulation of secretion by cell GO:1903530 249 0.051
norepinephrine secretion GO:0048243 2 0.050
locomotory behavior GO:0007626 195 0.050
response to extracellular stimulus GO:0009991 127 0.049
regulation of neuron apoptotic process GO:0043523 122 0.049
interspecies interaction between organisms GO:0044419 83 0.049
cellular response to peptide hormone stimulus GO:0071375 92 0.049
negative regulation of cellular component organization GO:0051129 194 0.049
positive regulation of acute inflammatory response GO:0002675 16 0.049
myeloid leukocyte activation GO:0002274 83 0.049
chromatin organization GO:0006325 206 0.048
regulation of hemostasis GO:1900046 28 0.048
positive regulation of cell development GO:0010720 237 0.048
positive regulation of protein transport GO:0051222 93 0.048
chromatin modification GO:0016568 187 0.048
positive regulation of cellular amine metabolic process GO:0033240 5 0.048
purine containing compound metabolic process GO:0072521 311 0.047
muscle tissue development GO:0060537 308 0.047
ras protein signal transduction GO:0007265 77 0.047
positive regulation of renal sodium excretion GO:0035815 2 0.047
gland development GO:0048732 330 0.047
peptidyl amino acid modification GO:0018193 336 0.047
ion transmembrane transport GO:0034220 361 0.047
regulation of cytoskeleton organization GO:0051493 122 0.047
establishment of endothelial blood brain barrier GO:0014045 3 0.046
regulation of circadian sleep wake cycle sleep GO:0045187 3 0.046
response to peptide hormone GO:0043434 127 0.046
multicellular organismal signaling GO:0035637 91 0.046
axonogenesis GO:0007409 274 0.045
cell matrix adhesion GO:0007160 68 0.045
regulation of circadian sleep wake cycle GO:0042749 3 0.045
regulation of lymphocyte apoptotic process GO:0070228 41 0.045
regulation of myeloid leukocyte differentiation GO:0002761 58 0.045
cytokine mediated signaling pathway GO:0019221 115 0.045
forebrain morphogenesis GO:0048853 17 0.044
defense response to bacterium GO:0042742 119 0.044
peptidyl tyrosine phosphorylation GO:0018108 143 0.044
adenylate cyclase activating g protein coupled receptor signaling pathway GO:0007189 30 0.044
norepinephrine transport GO:0015874 2 0.044
telencephalon development GO:0021537 186 0.044
pancreatic pp cell fate commitment GO:0003329 2 0.044
astrocyte differentiation GO:0048708 43 0.044
regulation of cellular component size GO:0032535 121 0.044
Mouse
kidney epithelium development GO:0072073 121 0.044
cellular response to growth factor stimulus GO:0071363 197 0.044
membrane invagination GO:0010324 17 0.043
negative regulation of leukocyte differentiation GO:1902106 51 0.043
regulation of protein localization GO:0032880 231 0.043
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.043
cardiac muscle tissue development GO:0048738 130 0.042
activation of mapk activity involved in innate immune response GO:0035419 2 0.042
positive regulation of cell death GO:0010942 224 0.042
nephron epithelium development GO:0072009 92 0.042
inner ear morphogenesis GO:0042472 101 0.042
camp metabolic process GO:0046058 40 0.042
central nervous system neuron differentiation GO:0021953 162 0.041
hormone metabolic process GO:0042445 86 0.041
neuroepithelial cell differentiation GO:0060563 37 0.041
modification of morphology or physiology of other organism involved in symbiotic interaction GO:0051817 16 0.041
positive regulation of lymphocyte differentiation GO:0045621 61 0.041
Mouse
cellular response to transforming growth factor beta stimulus GO:0071560 88 0.041
purine ribonucleotide biosynthetic process GO:0009152 59 0.040
regulation of lymphocyte differentiation GO:0045619 107 0.040
Mouse
pancreatic a cell fate commitment GO:0003326 2 0.040
granulocyte migration GO:0097530 43 0.040
regulation of intracellular transport GO:0032386 159 0.040
actin polymerization or depolymerization GO:0008154 54 0.040
regulation of wound healing GO:0061041 40 0.040
second messenger mediated signaling GO:0019932 73 0.039
positive regulation of chemotaxis GO:0050921 38 0.039
divalent inorganic cation transport GO:0072511 178 0.039
negative regulation of protein secretion GO:0050709 20 0.039
activation of mapk activity GO:0000187 59 0.039
nucleotide biosynthetic process GO:0009165 78 0.039
clara cell differentiation GO:0060486 4 0.039
nuclear division GO:0000280 158 0.038
negative regulation of adaptive immune response GO:0002820 25 0.038
Mouse
cellular amino acid metabolic process GO:0006520 103 0.038
negative regulation of interleukin 5 production GO:0032714 4 0.038
skeletal system development GO:0001501 356 0.037
heart valve development GO:0003170 23 0.037
peptidyl tyrosine modification GO:0018212 145 0.037
positive regulation of programmed cell death GO:0043068 218 0.037
binding of sperm to zona pellucida GO:0007339 34 0.037
immunoglobulin production GO:0002377 73 0.037
Mouse
rho protein signal transduction GO:0007266 32 0.037
t cell apoptotic process GO:0070231 39 0.037
renal system development GO:0072001 225 0.037
cell killing GO:0001906 67 0.037
Mouse
carboxylic acid biosynthetic process GO:0046394 86 0.036
response to insulin GO:0032868 100 0.036
negative regulation of cell activation GO:0050866 111 0.036
cellular lipid metabolic process GO:0044255 323 0.036
response to oxidative stress GO:0006979 123 0.036
positive regulation of cell migration GO:0030335 109 0.036
cell junction organization GO:0034330 77 0.036
camp biosynthetic process GO:0006171 31 0.036
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.036
placenta development GO:0001890 140 0.035
Mouse
epithelial cell development GO:0002064 159 0.035
positive regulation of nervous system development GO:0051962 221 0.035
angiogenesis GO:0001525 201 0.035
organelle fission GO:0048285 170 0.035
oxidation reduction process GO:0055114 342 0.035
regulation of ras protein signal transduction GO:0046578 114 0.035
cellular protein complex assembly GO:0043623 116 0.035
cellular extravasation GO:0045123 17 0.035
mating GO:0007618 27 0.035
regulation of reproductive process GO:2000241 66 0.034
positive regulation of cytokine production GO:0001819 174 0.034
purine ribonucleotide metabolic process GO:0009150 290 0.034
skeletal system morphogenesis GO:0048705 203 0.034
cardiac epithelial to mesenchymal transition GO:0060317 18 0.034
cyclic nucleotide biosynthetic process GO:0009190 44 0.034
immunoglobulin mediated immune response GO:0016064 69 0.034
regulation of cellular component biogenesis GO:0044087 181 0.034
posttranscriptional regulation of gene expression GO:0010608 155 0.034
pancreas development GO:0031016 57 0.033
regulation of hormone levels GO:0010817 211 0.033
purine nucleotide metabolic process GO:0006163 302 0.033
bone remodeling GO:0046849 53 0.032
negative regulation of protein modification process GO:0031400 163 0.032
phospholipid metabolic process GO:0006644 87 0.032
regulation of secretion GO:0051046 274 0.032
regulation of cardiac muscle cell proliferation GO:0060043 23 0.032
sensory perception GO:0007600 245 0.032
lipid biosynthetic process GO:0008610 179 0.032
positive regulation of intracellular transport GO:0032388 70 0.032
carbohydrate transport GO:0008643 62 0.032
heart valve morphogenesis GO:0003179 21 0.032
organic acid transport GO:0015849 101 0.032
granulocyte chemotaxis GO:0071621 39 0.032
regulation of morphogenesis of a branching structure GO:0060688 53 0.031
purine ribonucleoside metabolic process GO:0046128 241 0.031
negative regulation of ossification GO:0030279 49 0.031
digestive tract development GO:0048565 190 0.031
response to organic cyclic compound GO:0014070 198 0.031
engulfment of apoptotic cell GO:0043652 3 0.031
respiratory system development GO:0060541 190 0.031
positive regulation of thymocyte migration GO:2000412 2 0.031
heart process GO:0003015 94 0.031
fatty acid biosynthetic process GO:0006633 41 0.031
regulation of cell cycle process GO:0010564 160 0.031
nephric duct formation GO:0072179 4 0.031
nucleotide metabolic process GO:0009117 332 0.030
cyclic nucleotide metabolic process GO:0009187 59 0.030
heart contraction GO:0060047 93 0.030
inorganic cation transmembrane transport GO:0098662 207 0.030
striated muscle cell development GO:0055002 125 0.030
multi organism behavior GO:0051705 62 0.030
ribonucleotide metabolic process GO:0009259 291 0.030
negative regulation of hemostasis GO:1900047 11 0.030
bone resorption GO:0045453 38 0.030
protein acylation GO:0043543 64 0.030
regulation of immunoglobulin mediated immune response GO:0002889 37 0.030
regulation of glial cell differentiation GO:0045685 41 0.029
mitotic cell cycle process GO:1903047 159 0.029
protein catabolic process GO:0030163 221 0.029
regulation of regulated secretory pathway GO:1903305 20 0.029
regulation of lymphocyte mediated immunity GO:0002706 84 0.029
Mouse
sclerotome development GO:0061056 4 0.029
pharynx development GO:0060465 1 0.029
regulation of feeding behavior GO:0060259 3 0.029
cytokine biosynthetic process GO:0042089 68 0.029
phenol containing compound metabolic process GO:0018958 60 0.029
positive regulation of response to wounding GO:1903036 66 0.029
negative regulation of synapse assembly GO:0051964 3 0.029
branching morphogenesis of an epithelial tube GO:0048754 159 0.029
macromolecule methylation GO:0043414 120 0.029
regulation of cell projection organization GO:0031344 206 0.029
diencephalon development GO:0021536 63 0.029
regulation of cytoplasmic transport GO:1903649 112 0.029
erythrocyte differentiation GO:0030218 88 0.029
positive regulation of b cell activation GO:0050871 49 0.029
positive regulation of membrane protein ectodomain proteolysis GO:0051044 3 0.029
polarity specification of proximal distal axis GO:0010085 2 0.028
microtubule cytoskeleton organization GO:0000226 157 0.028
cellular response to abiotic stimulus GO:0071214 56 0.028
negative regulation of cellular protein metabolic process GO:0032269 247 0.028
negative regulation of coagulation GO:0050819 11 0.028
positive regulation of organelle organization GO:0010638 128 0.028
peptidyl lysine modification GO:0018205 77 0.028
regulation of mast cell activation GO:0033003 21 0.028
regulation of b cell activation GO:0050864 81 0.027
reactive oxygen species metabolic process GO:0072593 84 0.027
peptide hormone secretion GO:0030072 109 0.027
positive regulation of cellular component biogenesis GO:0044089 94 0.027
response to monosaccharide GO:0034284 67 0.027
camera type eye development GO:0043010 266 0.027
bmp signaling pathway GO:0030509 93 0.027
response to light stimulus GO:0009416 135 0.027
response to decreased oxygen levels GO:0036293 59 0.027
proteoglycan metabolic process GO:0006029 38 0.027
response to peptide GO:1901652 136 0.026
positive regulation of nf kappab transcription factor activity GO:0051092 30 0.026
organic anion transport GO:0015711 137 0.026
calcium ion transport GO:0006816 159 0.026
positive regulation of stem cell differentiation GO:2000738 23 0.026
response to inorganic substance GO:0010035 96 0.026
regulation of transporter activity GO:0032409 57 0.026
regulation of system process GO:0044057 200 0.026
regulation of cytokine biosynthetic process GO:0042035 59 0.026
regulation of cell shape GO:0008360 39 0.026
regulation of t cell differentiation GO:0045580 83 0.026
Mouse
positive regulation of eosinophil migration GO:2000418 2 0.026
thymocyte migration GO:0072679 2 0.026
regulation of norepinephrine secretion GO:0014061 2 0.026
regulation of chromosome organization GO:0033044 83 0.026
regulation of cartilage development GO:0061035 44 0.026
carbohydrate biosynthetic process GO:0016051 74 0.026
floor plate morphogenesis GO:0033505 3 0.026
regulation of cardioblast differentiation GO:0051890 3 0.026
regulation of histone modification GO:0031056 56 0.026
negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 23 0.025
Mouse
regulation of protein maturation GO:1903317 96 0.025
fat cell differentiation GO:0045444 160 0.025
positive regulation of t cell activation GO:0050870 101 0.025
Mouse
mesodermal cell migration GO:0008078 4 0.025
small gtpase mediated signal transduction GO:0007264 97 0.025
negative regulation of cell cycle GO:0045786 123 0.025
paraxial mesodermal cell differentiation GO:0048342 2 0.025
monosaccharide transport GO:0015749 58 0.025
positive regulation of cardiac muscle tissue growth GO:0055023 15 0.025
regulation of translation GO:0006417 71 0.025
mesoderm morphogenesis GO:0048332 64 0.025
regulation of steroid metabolic process GO:0019218 39 0.025
regulation of proteolysis GO:0030162 164 0.025
ventricular cardiac muscle tissue development GO:0003229 38 0.025
positive regulation of leukocyte apoptotic process GO:2000108 21 0.025
cardiac chamber morphogenesis GO:0003206 93 0.025
protein modification by small protein conjugation GO:0032446 187 0.024
regulation of ion transmembrane transporter activity GO:0032412 54 0.024
response to alkaloid GO:0043279 34 0.024
regulation of t cell apoptotic process GO:0070232 28 0.024
positive regulation of cell morphogenesis involved in differentiation GO:0010770 72 0.024
cell cell junction organization GO:0045216 72 0.024
replacement ossification GO:0036075 26 0.024
positive regulation of production of molecular mediator of immune response GO:0002702 45 0.024
response to oxygen levels GO:0070482 62 0.024
positive regulation of cardioblast differentiation GO:0051891 3 0.024
t cell migration GO:0072678 19 0.024

Mpl disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
immune system disease DOID:2914 0 0.101
disease of anatomical entity DOID:7 0 0.101
hematopoietic system disease DOID:74 0 0.048
hemorrhagic disease DOID:2213 0 0.041
blood coagulation disease DOID:1247 0 0.041
blood platelet disease DOID:2218 0 0.037