Mus musculus

104 known processes

Msh6

mutS homolog 6 (E. coli)

(Aliases: AW550279,GTBP,Gtmbp,AU044881)

Msh6 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
dna metabolic process GO:0006259 303 0.451
mitotic cell cycle process GO:1903047 159 0.279
intrinsic apoptotic signaling pathway GO:0097193 132 0.249
cellular response to dna damage stimulus GO:0006974 207 0.227
regulation of cell cycle GO:0051726 281 0.181
apoptotic signaling pathway GO:0097190 306 0.179
nucleic acid phosphodiester bond hydrolysis GO:0090305 49 0.154
mitotic cell cycle GO:0000278 195 0.135
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 57 0.132
glycosyl compound metabolic process GO:1901657 246 0.130
Human Yeast
mrna splicing via spliceosome GO:0000398 43 0.114
regulation of cell cycle phase transition GO:1901987 77 0.110
meiotic nuclear division GO:0007126 115 0.107
Yeast
dna recombination GO:0006310 92 0.103
response to radiation GO:0009314 165 0.101
dna repair GO:0006281 107 0.100
rna processing GO:0006396 105 0.098
germ cell development GO:0007281 185 0.091
maturation of 5 8s rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna GO:0000466 1 0.090
aromatic compound catabolic process GO:0019439 286 0.089
Human Yeast
organelle fission GO:0048285 170 0.084
Yeast
rna phosphodiester bond hydrolysis exonucleolytic GO:0090503 4 0.081
myeloid cell differentiation GO:0030099 233 0.077
purine ribonucleoside catabolic process GO:0046130 205 0.076
Human Yeast
atp catabolic process GO:0006200 55 0.076
Human Yeast
rhythmic process GO:0048511 174 0.074
nucleoside phosphate catabolic process GO:1901292 222 0.071
Human Yeast
nucleoside catabolic process GO:0009164 206 0.071
Human Yeast
spermatogenesis GO:0007283 284 0.068
purine nucleoside metabolic process GO:0042278 241 0.068
Human Yeast
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 43 0.067
regulation of response to wounding GO:1903034 189 0.066
ribonucleotide catabolic process GO:0009261 208 0.063
Human Yeast
nucleotide metabolic process GO:0009117 332 0.063
Human Yeast
purine nucleotide metabolic process GO:0006163 302 0.062
Human Yeast
nucleoside monophosphate metabolic process GO:0009123 85 0.060
Human Yeast
nucleotide catabolic process GO:0009166 217 0.059
Human Yeast
mrna metabolic process GO:0016071 84 0.059
purine nucleoside triphosphate catabolic process GO:0009146 203 0.058
Human Yeast
purine nucleoside monophosphate catabolic process GO:0009128 58 0.058
Human Yeast
cell fate commitment GO:0045165 210 0.057
nucleoside metabolic process GO:0009116 246 0.056
Human Yeast
regulation of cell cycle process GO:0010564 160 0.055
chromosome segregation GO:0007059 48 0.055
covalent chromatin modification GO:0016569 163 0.053
muscle cell differentiation GO:0042692 261 0.052
double strand break repair GO:0006302 48 0.052
histone modification GO:0016570 159 0.052
macromolecule catabolic process GO:0009057 281 0.052
snrna metabolic process GO:0016073 1 0.051
regulation of mitotic cell cycle phase transition GO:1901990 73 0.050
positive regulation of apoptotic process GO:0043065 217 0.049
negative regulation of protein modification process GO:0031400 163 0.047
ribonucleotide metabolic process GO:0009259 291 0.047
Human Yeast
regulation of apoptotic signaling pathway GO:2001233 197 0.046
response to organonitrogen compound GO:0010243 246 0.046
methylation GO:0032259 134 0.046
meiotic cell cycle GO:0051321 122 0.045
Yeast
cell cycle g1 s phase transition GO:0044843 57 0.043
regulation of intracellular transport GO:0032386 159 0.043
morphogenesis of a branching epithelium GO:0061138 193 0.042
lateral inhibition GO:0046331 1 0.042
microtubule based process GO:0007017 236 0.042
male gamete generation GO:0048232 285 0.040
intracellular mrna localization GO:0008298 4 0.040
cell division GO:0051301 120 0.040
circadian rhythm GO:0007623 114 0.040
nucleobase containing small molecule metabolic process GO:0055086 352 0.040
Human Yeast
chromatin modification GO:0016568 187 0.040
g1 s transition of mitotic cell cycle GO:0000082 57 0.039
cellular macromolecule catabolic process GO:0044265 206 0.038
purine ribonucleoside metabolic process GO:0046128 241 0.037
Human Yeast
response to ionizing radiation GO:0010212 42 0.037
heterocycle catabolic process GO:0046700 280 0.037
Human Yeast
negative regulation of mitotic cell cycle phase transition GO:1901991 45 0.037
cellular amino acid metabolic process GO:0006520 103 0.037
maintenance of location GO:0051235 89 0.037
cell type specific apoptotic process GO:0097285 268 0.036
ribonucleoside metabolic process GO:0009119 245 0.036
Human Yeast
purine nucleotide catabolic process GO:0006195 211 0.036
Human Yeast
oxidation reduction process GO:0055114 342 0.036
negative regulation of cellular protein metabolic process GO:0032269 247 0.035
ribonucleoside triphosphate catabolic process GO:0009203 199 0.035
Human Yeast
endocytosis GO:0006897 168 0.035
rna splicing via transesterification reactions GO:0000375 43 0.035
ribonucleoprotein complex subunit organization GO:0071826 28 0.035
ncrna 3 end processing GO:0043628 2 0.034
microtubule cytoskeleton organization GO:0000226 157 0.034
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.033
Human Yeast
response to light stimulus GO:0009416 135 0.033
cellular response to organonitrogen compound GO:0071417 145 0.033
negative regulation of molecular function GO:0044092 258 0.032
response to peptide GO:1901652 136 0.032
myeloid leukocyte differentiation GO:0002573 119 0.032
angiogenesis GO:0001525 201 0.032
rna splicing GO:0008380 54 0.031
purine nucleoside catabolic process GO:0006152 205 0.031
Human Yeast
positive regulation of cell death GO:0010942 224 0.031
positive regulation of apoptotic signaling pathway GO:2001235 95 0.030
purine ribonucleotide metabolic process GO:0009150 290 0.030
Human Yeast
epithelial tube morphogenesis GO:0060562 303 0.030
purine containing compound metabolic process GO:0072521 311 0.030
Human Yeast
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.029
nucleoside monophosphate catabolic process GO:0009125 59 0.029
Human Yeast
positive regulation of programmed cell death GO:0043068 218 0.029
regulation of circadian rhythm GO:0042752 58 0.028
purine containing compound catabolic process GO:0072523 213 0.027
Human Yeast
female gamete generation GO:0007292 74 0.027
purine nucleoside triphosphate metabolic process GO:0009144 226 0.027
Human Yeast
cell cycle checkpoint GO:0000075 47 0.027
sister chromatid segregation GO:0000819 20 0.027
leukocyte differentiation GO:0002521 342 0.027
membrane organization GO:0061024 245 0.027
blood vessel morphogenesis GO:0048514 285 0.027
amine metabolic process GO:0009308 45 0.026
peptidyl lysine modification GO:0018205 77 0.026
purine ribonucleotide catabolic process GO:0009154 208 0.026
Human Yeast
response to organic cyclic compound GO:0014070 198 0.025
organism emergence from protective structure GO:0071684 4 0.025
regulation of organelle organization GO:0033043 289 0.025
protein catabolic process GO:0030163 221 0.025
purine nucleoside monophosphate metabolic process GO:0009126 81 0.025
Human Yeast
immunoglobulin production GO:0002377 73 0.025
regulation of establishment of protein localization GO:0070201 181 0.025
posttranscriptional regulation of gene expression GO:0010608 155 0.025
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.025
Human Yeast
chromatin organization GO:0006325 206 0.024
mitotic nuclear division GO:0007067 48 0.024
cellular response to radiation GO:0071478 28 0.024
regulation of myeloid cell differentiation GO:0045637 96 0.024
production of molecular mediator of immune response GO:0002440 103 0.024
regulation of g1 s transition of mitotic cell cycle GO:2000045 35 0.024
ribonucleoside triphosphate metabolic process GO:0009199 220 0.023
Human Yeast
snrna processing GO:0016180 1 0.023
cellular ketone metabolic process GO:0042180 84 0.023
ribose phosphate metabolic process GO:0019693 291 0.023
Human Yeast
organonitrogen compound catabolic process GO:1901565 264 0.023
Human Yeast
morphogenesis of embryonic epithelium GO:0016331 159 0.023
cleavage involved in rrna processing GO:0000469 1 0.022
cellular protein catabolic process GO:0044257 155 0.022
carbohydrate derivative catabolic process GO:1901136 231 0.022
Human Yeast
glycosyl compound catabolic process GO:1901658 206 0.022
Human Yeast
modification dependent macromolecule catabolic process GO:0043632 133 0.022
positive regulation of immune effector process GO:0002699 107 0.022
protein modification by small protein conjugation or removal GO:0070647 207 0.022
nuclear division GO:0000280 158 0.022
Yeast
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.021
Human Yeast
regulation of mitotic cell cycle GO:0007346 126 0.021
camera type eye development GO:0043010 266 0.021
organelle assembly GO:0070925 177 0.021
nucleoside phosphate metabolic process GO:0006753 338 0.021
Human Yeast
regulation of protein transport GO:0051223 163 0.021
dna replication GO:0006260 52 0.021
ossification GO:0001503 216 0.021
b cell activation GO:0042113 161 0.020
regulation of cellular amino acid metabolic process GO:0006521 5 0.020
nucleoside triphosphate catabolic process GO:0009143 205 0.020
Human Yeast
negative regulation of protein metabolic process GO:0051248 282 0.020
cellular amine metabolic process GO:0044106 44 0.020
regulation of intrinsic apoptotic signaling pathway GO:2001242 61 0.020
organophosphate catabolic process GO:0046434 232 0.020
Human Yeast
regulation of inflammatory response GO:0050727 147 0.020
negative regulation of histone h3 k9 methylation GO:0051573 4 0.019
macromolecule methylation GO:0043414 120 0.019
negative regulation of cell proliferation GO:0008285 296 0.019
locomotory behavior GO:0007626 195 0.019
developmental maturation GO:0021700 193 0.019
antimicrobial peptide production GO:0002775 2 0.019
regulation of proteolysis GO:0030162 164 0.019
regulation of response to dna damage stimulus GO:2001020 34 0.019
organic cyclic compound catabolic process GO:1901361 295 0.019
Human Yeast
somatic diversification of immunoglobulins GO:0016445 43 0.019
embryonic epithelial tube formation GO:0001838 130 0.019
histone methylation GO:0016571 71 0.019
regulation of chromosome organization GO:0033044 83 0.018
compound eye development GO:0048749 1 0.018
modification dependent protein catabolic process GO:0019941 133 0.018
ubiquitin dependent protein catabolic process GO:0006511 129 0.018
maturation of 5 8s rrna GO:0000460 1 0.018
regulation of hormone levels GO:0010817 211 0.018
regulation of cell cycle g1 s phase transition GO:1902806 35 0.018
rna 3 end processing GO:0031123 20 0.018
nucleocytoplasmic transport GO:0006913 139 0.018
centromere complex assembly GO:0034508 3 0.018
cell maturation GO:0048469 127 0.018
anatomical structure homeostasis GO:0060249 145 0.017
protein localization to chromosome centromeric region GO:0071459 1 0.017
positive regulation of protein modification process GO:0031401 299 0.017
circadian regulation of gene expression GO:0032922 48 0.017
ribonucleoside catabolic process GO:0042454 206 0.017
Human Yeast
regulation of cellular component biogenesis GO:0044087 181 0.017
regulation of mrna stability GO:0043488 23 0.017
negative regulation of cell cycle phase transition GO:1901988 48 0.017
development of primary sexual characteristics GO:0045137 143 0.017
response to inorganic substance GO:0010035 96 0.017
regulation of defense response GO:0031347 233 0.017
response to oxidative stress GO:0006979 123 0.016
skin development GO:0043588 220 0.016
protein localization to organelle GO:0033365 185 0.016
nucleus organization GO:0006997 45 0.016
connective tissue development GO:0061448 179 0.016
regulation of cytoplasmic transport GO:1903649 112 0.016
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.016
nucleoside triphosphate metabolic process GO:0009141 230 0.016
Human Yeast
positive regulation of neuron differentiation GO:0045666 141 0.016
positive regulation of proteolysis GO:0045862 85 0.016
somatic cell dna recombination GO:0016444 51 0.016
ribonucleoside monophosphate catabolic process GO:0009158 57 0.016
Human Yeast
regulation of cellular response to stress GO:0080135 159 0.016
somatic stem cell maintenance GO:0035019 47 0.016
positive regulation of organelle organization GO:0010638 128 0.016
myeloid cell homeostasis GO:0002262 114 0.015
cytoplasmic transport GO:0016482 234 0.015
organonitrogen compound biosynthetic process GO:1901566 192 0.015
digestive tract development GO:0048565 190 0.015
regulation of cellular ketone metabolic process GO:0010565 66 0.015
regulation of neuron death GO:1901214 134 0.015
oogenesis GO:0048477 56 0.015
response to peptide hormone GO:0043434 127 0.015
positive regulation of cell cycle GO:0045787 92 0.015
neuron apoptotic process GO:0051402 142 0.015
cellular protein complex assembly GO:0043623 116 0.014
lymphocyte mediated immunity GO:0002449 139 0.014
protein acylation GO:0043543 64 0.014
protein modification by small protein conjugation GO:0032446 187 0.014
blastocyst development GO:0001824 80 0.014
stem cell development GO:0048864 219 0.014
negative regulation of synapse assembly GO:0051964 3 0.014
regulation of intracellular protein transport GO:0033157 82 0.014
oocyte anterior posterior axis specification GO:0007314 2 0.014
mitotic sister chromatid segregation GO:0000070 14 0.014
intracellular receptor signaling pathway GO:0030522 74 0.014
cell adhesion GO:0007155 329 0.014
response to lipopolysaccharide GO:0032496 128 0.014
hematopoietic progenitor cell differentiation GO:0002244 143 0.014
lipid localization GO:0010876 126 0.014
cellular nitrogen compound catabolic process GO:0044270 280 0.014
Human Yeast
negative regulation of cellular component organization GO:0051129 194 0.014
regulation of nucleocytoplasmic transport GO:0046822 73 0.014
sister chromatid cohesion GO:0007062 12 0.013
morphogenesis of a branching structure GO:0001763 203 0.013
regulation of chromatin silencing GO:0031935 2 0.013
cellular response to abiotic stimulus GO:0071214 56 0.013
dna damage response signal transduction by p53 class mediator GO:0030330 19 0.013
establishment of organelle localization GO:0051656 122 0.013
cell growth GO:0016049 130 0.013
cellular response to transforming growth factor beta stimulus GO:0071560 88 0.013
inflammatory response GO:0006954 244 0.013
regulation of cell activation GO:0050865 289 0.013
ribonucleoside monophosphate metabolic process GO:0009161 80 0.013
Human Yeast
erythrocyte differentiation GO:0030218 88 0.013
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.013
translation GO:0006412 93 0.013
establishment of protein localization to organelle GO:0072594 118 0.013
engulfment of apoptotic cell GO:0043652 3 0.012
regulation of system process GO:0044057 200 0.012
epidermis development GO:0008544 187 0.012
positive regulation of rna polymerase ii transcriptional preinitiation complex assembly GO:0045899 2 0.012
epithelial tube formation GO:0072175 130 0.012
snrna 3 end processing GO:0034472 1 0.012
maturation of ssu rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna GO:0000462 1 0.012
neuroblast differentiation GO:0014016 2 0.012
rna phosphodiester bond hydrolysis GO:0090501 19 0.012
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.012
fat cell differentiation GO:0045444 160 0.012
positive regulation of chromosome organization GO:2001252 33 0.012
lipid biosynthetic process GO:0008610 179 0.012
spermatid development GO:0007286 108 0.012
positive regulation of cell morphogenesis involved in differentiation GO:0010770 72 0.012
rhythmic behavior GO:0007622 15 0.012
gene silencing by rna GO:0031047 19 0.012
t cell activation GO:0042110 289 0.012
negative regulation of mitotic cell cycle GO:0045930 58 0.012
protein ubiquitination GO:0016567 171 0.012
glial cell differentiation GO:0010001 131 0.012
protein dna complex subunit organization GO:0071824 28 0.012
maternal determination of anterior posterior axis embryo GO:0008358 2 0.012
branching morphogenesis of an epithelial tube GO:0048754 159 0.012
internal peptidyl lysine acetylation GO:0018393 42 0.012
male meiosis i GO:0007141 16 0.012
lymphocyte differentiation GO:0030098 242 0.012
positive regulation of nervous system development GO:0051962 221 0.012
mrna processing GO:0006397 63 0.012
peptidyl amino acid modification GO:0018193 336 0.012
protein maturation GO:0051604 176 0.012
dna conformation change GO:0071103 37 0.011
rna interference GO:0016246 2 0.011
dna integrity checkpoint GO:0031570 28 0.011
positive regulation of cellular component biogenesis GO:0044089 94 0.011
intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 19 0.011
nuclear transport GO:0051169 139 0.011
histone lysine methylation GO:0034968 50 0.011
multicellular organismal signaling GO:0035637 91 0.011
ncrna processing GO:0034470 26 0.011
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.011
internal protein amino acid acetylation GO:0006475 42 0.011
endomembrane system organization GO:0010256 147 0.011
synaptic transmission GO:0007268 329 0.011
axonogenesis GO:0007409 274 0.011
regulation of interleukin 1 alpha production GO:0032650 4 0.011
positive regulation of mitotic cell cycle phase transition GO:1901992 17 0.011
ventricular septum morphogenesis GO:0060412 27 0.011
cellular response to organic cyclic compound GO:0071407 87 0.011
pole plasm assembly GO:0007315 2 0.011
glucose homeostasis GO:0042593 128 0.011
antimicrobial peptide biosynthetic process GO:0002777 2 0.011
cellular response to light stimulus GO:0071482 19 0.011
positive regulation of production of molecular mediator of immune response GO:0002702 45 0.011
positive regulation of cytokine production GO:0001819 174 0.011
hindbrain development GO:0030902 128 0.011
cellular response to hormone stimulus GO:0032870 150 0.011
regulation of nuclear division GO:0051783 56 0.011
regulation of neuron projection development GO:0010975 169 0.011
intracellular protein transport GO:0006886 204 0.011
dna damage checkpoint GO:0000077 26 0.011
homeostasis of number of cells GO:0048872 210 0.011
positive regulation of adaptive immune response GO:0002821 61 0.011
tube formation GO:0035148 140 0.011
cellular chemical homeostasis GO:0055082 215 0.011
positive regulation of intracellular protein transport GO:0090316 42 0.011
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.010
carbohydrate homeostasis GO:0033500 128 0.010
leukocyte mediated immunity GO:0002443 174 0.010
regulation of transferase activity GO:0051338 263 0.010
proteasomal protein catabolic process GO:0010498 98 0.010
mrna destabilization GO:0061157 4 0.010
tissue homeostasis GO:0001894 115 0.010
positive regulation of protein phosphorylation GO:0001934 242 0.010
negative regulation of cell cycle GO:0045786 123 0.010
negative regulation of apoptotic signaling pathway GO:2001234 104 0.010
nuclear dna replication GO:0033260 3 0.010
response to transforming growth factor beta GO:0071559 88 0.010

Msh6 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.063
Human
disease of cellular proliferation DOID:14566 0 0.063
Human
organ system cancer DOID:0050686 0 0.055
Human
disease of anatomical entity DOID:7 0 0.042
nervous system disease DOID:863 0 0.042
central nervous system disease DOID:331 0 0.028
neurodegenerative disease DOID:1289 0 0.013
thoracic cancer DOID:5093 0 0.012
breast cancer DOID:1612 0 0.011
motor neuron disease DOID:231 0 0.010
amyotrophic lateral sclerosis DOID:332 0 0.010