Mus musculus

0 known processes

Mthfd1

methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase

(Aliases: Dcs,Mthfd,E430024A07Rik)

Mthfd1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
purine containing compound metabolic process GO:0072521 311 0.265
cellular nitrogen compound catabolic process GO:0044270 280 0.176
cellular amino acid metabolic process GO:0006520 103 0.145
nucleobase containing small molecule metabolic process GO:0055086 352 0.145
glycosyl compound metabolic process GO:1901657 246 0.144
organonitrogen compound biosynthetic process GO:1901566 192 0.142
organic cyclic compound catabolic process GO:1901361 295 0.133
nucleoside metabolic process GO:0009116 246 0.128
nucleoside phosphate metabolic process GO:0006753 338 0.122
ribonucleoside metabolic process GO:0009119 245 0.110
heterocycle catabolic process GO:0046700 280 0.104
aromatic compound catabolic process GO:0019439 286 0.097
purine nucleotide metabolic process GO:0006163 302 0.095
alpha amino acid metabolic process GO:1901605 59 0.089
alpha amino acid biosynthetic process GO:1901607 15 0.087
nucleoside triphosphate metabolic process GO:0009141 230 0.087
nucleoside monophosphate metabolic process GO:0009123 85 0.085
purine nucleoside triphosphate metabolic process GO:0009144 226 0.080
transmembrane transport GO:0055085 412 0.080
purine ribonucleotide metabolic process GO:0009150 290 0.074
oxidation reduction process GO:0055114 342 0.071
nucleotide metabolic process GO:0009117 332 0.069
purine nucleoside metabolic process GO:0042278 241 0.068
ion transmembrane transport GO:0034220 361 0.066
response to oxidative stress GO:0006979 123 0.066
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.062
ribose phosphate metabolic process GO:0019693 291 0.062
ribonucleoside triphosphate metabolic process GO:0009199 220 0.060
ribonucleotide metabolic process GO:0009259 291 0.060
organonitrogen compound catabolic process GO:1901565 264 0.057
cation transport GO:0006812 399 0.056
purine ribonucleoside metabolic process GO:0046128 241 0.054
cellular ketone metabolic process GO:0042180 84 0.053
amine metabolic process GO:0009308 45 0.053
regulation of cellular amino acid metabolic process GO:0006521 5 0.053
cellular amino acid biosynthetic process GO:0008652 22 0.052
regulation of cellular ketone metabolic process GO:0010565 66 0.051
positive regulation of cellular amine metabolic process GO:0033240 5 0.051
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.049
regulation of ion transport GO:0043269 215 0.048
purine nucleoside catabolic process GO:0006152 205 0.048
cellular modified amino acid metabolic process GO:0006575 63 0.045
atp metabolic process GO:0046034 75 0.044
cytokine production GO:0001816 319 0.041
nucleoside phosphate catabolic process GO:1901292 222 0.040
regulation of transmembrane transport GO:0034762 128 0.040
translation GO:0006412 93 0.039
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.038
cellular amino acid catabolic process GO:0009063 25 0.037
purine containing compound catabolic process GO:0072523 213 0.036
nucleoside triphosphate catabolic process GO:0009143 205 0.036
regulation of cellular amine metabolic process GO:0033238 20 0.035
inorganic cation transmembrane transport GO:0098662 207 0.035
carboxylic acid biosynthetic process GO:0046394 86 0.035
intrinsic apoptotic signaling pathway GO:0097193 132 0.035
cellular macromolecule catabolic process GO:0044265 206 0.035
cellular amine metabolic process GO:0044106 44 0.034
nucleotide catabolic process GO:0009166 217 0.034
ribonucleoside monophosphate metabolic process GO:0009161 80 0.033
carbohydrate derivative catabolic process GO:1901136 231 0.033
cation transmembrane transport GO:0098655 266 0.032
purine ribonucleoside catabolic process GO:0046130 205 0.032
posttranscriptional regulation of gene expression GO:0010608 155 0.032
defecation GO:0030421 1 0.032
regulation of defense response GO:0031347 233 0.032
immune effector process GO:0002252 321 0.030
regulation of translation GO:0006417 71 0.030
regulation of membrane potential GO:0042391 192 0.030
peptidyl amino acid modification GO:0018193 336 0.030
ribonucleotide catabolic process GO:0009261 208 0.030
anion transport GO:0006820 177 0.029
cellular response to dna damage stimulus GO:0006974 207 0.029
gland development GO:0048732 330 0.029
macromolecule catabolic process GO:0009057 281 0.029
organic acid biosynthetic process GO:0016053 86 0.029
generation of precursor metabolites and energy GO:0006091 103 0.029
inflammatory response GO:0006954 244 0.029
regulation of organelle organization GO:0033043 289 0.028
multicellular organismal homeostasis GO:0048871 164 0.028
regulation of ion transmembrane transport GO:0034765 119 0.028
apoptotic signaling pathway GO:0097190 306 0.028
purine nucleoside monophosphate metabolic process GO:0009126 81 0.028
purine ribonucleotide catabolic process GO:0009154 208 0.028
regulation of cytokine production GO:0001817 266 0.027
cellular modified amino acid biosynthetic process GO:0042398 12 0.027
intracellular protein transport GO:0006886 204 0.027
positive regulation of cell development GO:0010720 237 0.026
regulation of feeding behavior GO:0060259 3 0.025
nucleoside catabolic process GO:0009164 206 0.025
negative regulation of oxidative stress induced intrinsic apoptotic signaling pathway GO:1902176 4 0.025
cytoplasmic transport GO:0016482 234 0.025
membrane organization GO:0061024 245 0.025
dna metabolic process GO:0006259 303 0.025
positive regulation of cell death GO:0010942 224 0.024
regulation of hydrolase activity GO:0051336 246 0.024
purine nucleoside triphosphate catabolic process GO:0009146 203 0.024
carbohydrate derivative biosynthetic process GO:1901137 183 0.024
response to organonitrogen compound GO:0010243 246 0.023
purine nucleotide catabolic process GO:0006195 211 0.023
chemotaxis GO:0006935 247 0.023
small molecule biosynthetic process GO:0044283 132 0.023
nitrogen compound transport GO:0071705 271 0.022
ribonucleoside triphosphate catabolic process GO:0009203 199 0.022
lymphocyte proliferation GO:0046651 164 0.022
cellular metal ion homeostasis GO:0006875 151 0.022
regulation of nucleotide metabolic process GO:0006140 169 0.021
regulation of purine nucleotide metabolic process GO:1900542 169 0.021
anatomical structure homeostasis GO:0060249 145 0.021
small gtpase mediated signal transduction GO:0007264 97 0.021
leukocyte chemotaxis GO:0030595 69 0.021
regulation of cellular response to stress GO:0080135 159 0.021
regulation of transporter activity GO:0032409 57 0.021
organophosphate catabolic process GO:0046434 232 0.020
purine containing compound biosynthetic process GO:0072522 70 0.020
nucleotide biosynthetic process GO:0009165 78 0.020
positive regulation of cytokine production GO:0001819 174 0.020
small molecule catabolic process GO:0044282 71 0.020
coenzyme metabolic process GO:0006732 52 0.020
endocytosis GO:0006897 168 0.020
carboxylic acid catabolic process GO:0046395 51 0.020
cellular homeostasis GO:0019725 240 0.020
mrna splicing via spliceosome GO:0000398 43 0.019
sensory perception GO:0007600 245 0.019
defense response to other organism GO:0098542 197 0.019
inorganic ion transmembrane transport GO:0098660 234 0.019
ribonucleoside catabolic process GO:0042454 206 0.019
mitochondrion organization GO:0007005 134 0.019
response to endoplasmic reticulum stress GO:0034976 53 0.019
positive regulation of protein modification process GO:0031401 299 0.019
synaptic transmission GO:0007268 329 0.019
cellular protein complex assembly GO:0043623 116 0.019
regulation of metal ion transport GO:0010959 106 0.019
cellular lipid metabolic process GO:0044255 323 0.018
cell adhesion GO:0007155 329 0.018
male gamete generation GO:0048232 285 0.018
cellular chemical homeostasis GO:0055082 215 0.018
divalent inorganic cation homeostasis GO:0072507 138 0.018
response to oxygen radical GO:0000305 16 0.018
cation homeostasis GO:0055080 212 0.018
cellular ion homeostasis GO:0006873 165 0.018
nucleoside phosphate biosynthetic process GO:1901293 79 0.018
organelle fission GO:0048285 170 0.017
divalent metal ion transport GO:0070838 172 0.017
regulation of cell motility GO:2000145 236 0.017
negative regulation of intracellular signal transduction GO:1902532 167 0.017
lymphocyte mediated immunity GO:0002449 139 0.017
locomotory behavior GO:0007626 195 0.017
calcium ion transport GO:0006816 159 0.017
organophosphate biosynthetic process GO:0090407 122 0.017
ribonucleoside monophosphate catabolic process GO:0009158 57 0.017
metal ion homeostasis GO:0055065 189 0.017
mrna metabolic process GO:0016071 84 0.017
lateral inhibition GO:0046331 1 0.017
regulation of ion transmembrane transporter activity GO:0032412 54 0.017
circulatory system process GO:0003013 197 0.017
tissue homeostasis GO:0001894 115 0.017
cellular response to oxidative stress GO:0034599 76 0.016
regulation of nucleoside metabolic process GO:0009118 130 0.016
dna modification GO:0006304 50 0.016
cellular aldehyde metabolic process GO:0006081 12 0.016
regulation of response to wounding GO:1903034 189 0.016
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.016
protein processing GO:0016485 163 0.016
ras protein signal transduction GO:0007265 77 0.016
negative regulation of molecular function GO:0044092 258 0.016
positive regulation of programmed cell death GO:0043068 218 0.016
multicellular organismal signaling GO:0035637 91 0.015
regulation of intracellular transport GO:0032386 159 0.015
response to acid chemical GO:0001101 111 0.015
regulation of mitochondrion organization GO:0010821 27 0.015
rna catabolic process GO:0006401 29 0.015
epithelial tube morphogenesis GO:0060562 303 0.015
divalent inorganic cation transport GO:0072511 178 0.015
microtubule cytoskeleton organization GO:0000226 157 0.015
regulation of establishment of protein localization GO:0070201 181 0.015
intracellular receptor signaling pathway GO:0030522 74 0.015
negative regulation of cell proliferation GO:0008285 296 0.015
homeostasis of number of cells GO:0048872 210 0.015
leukocyte migration GO:0050900 124 0.015
regulation of multi organism process GO:0043900 111 0.015
neuron apoptotic process GO:0051402 142 0.015
innate immune response GO:0045087 157 0.015
heart process GO:0003015 94 0.015
sulfur compound metabolic process GO:0006790 100 0.014
mapk cascade GO:0000165 281 0.014
positive regulation of immune effector process GO:0002699 107 0.014
response to organic cyclic compound GO:0014070 198 0.014
regulation of cellular catabolic process GO:0031329 242 0.014
regulation of neuron differentiation GO:0045664 281 0.014
nucleocytoplasmic transport GO:0006913 139 0.014
positive regulation of apoptotic process GO:0043065 217 0.014
cell type specific apoptotic process GO:0097285 268 0.014
regulation of mrna metabolic process GO:1903311 43 0.014
regulation of cell activation GO:0050865 289 0.014
histone modification GO:0016570 159 0.014
urogenital system development GO:0001655 261 0.014
adult behavior GO:0030534 135 0.014
response to peptide hormone GO:0043434 127 0.014
alpha amino acid catabolic process GO:1901606 18 0.014
blood circulation GO:0008015 195 0.014
activation of immune response GO:0002253 138 0.014
production of molecular mediator of immune response GO:0002440 103 0.014
rna 3 end processing GO:0031123 20 0.014
sodium ion transport GO:0006814 73 0.014
protein maturation GO:0051604 176 0.014
cellular response to organonitrogen compound GO:0071417 145 0.014
immune response regulating signaling pathway GO:0002764 125 0.014
action potential GO:0001508 78 0.014
cell substrate adhesion GO:0031589 130 0.014
negative regulation of phosphate metabolic process GO:0045936 184 0.013
regulation of inflammatory response GO:0050727 147 0.013
regulation of response to biotic stimulus GO:0002831 38 0.013
cell activation involved in immune response GO:0002263 126 0.013
protein oligomerization GO:0051259 67 0.013
spermatogenesis GO:0007283 284 0.013
germ cell development GO:0007281 185 0.013
carbohydrate metabolic process GO:0005975 230 0.013
response to peptide GO:1901652 136 0.013
serine family amino acid metabolic process GO:0009069 7 0.013
signal transduction by p53 class mediator GO:0072331 51 0.013
negative regulation of cellular component organization GO:0051129 194 0.013
response to extracellular stimulus GO:0009991 127 0.013
positive regulation of protein phosphorylation GO:0001934 242 0.013
endomembrane system organization GO:0010256 147 0.013
cofactor metabolic process GO:0051186 80 0.013
gtp metabolic process GO:0046039 144 0.013
response to radiation GO:0009314 165 0.013
calcium ion homeostasis GO:0055074 127 0.013
organic hydroxy compound metabolic process GO:1901615 203 0.013
glycoprotein metabolic process GO:0009100 116 0.012
b cell activation GO:0042113 161 0.012
dna repair GO:0006281 107 0.012
leukocyte proliferation GO:0070661 172 0.012
regulation of hormone levels GO:0010817 211 0.012
myeloid cell differentiation GO:0030099 233 0.012
regulation of oxidative phosphorylation GO:0002082 6 0.012
negative regulation of multi organism process GO:0043901 68 0.012
regulation of apoptotic signaling pathway GO:2001233 197 0.012
neuron death GO:0070997 154 0.012
folic acid containing compound metabolic process GO:0006760 3 0.012
regulation of cytoplasmic transport GO:1903649 112 0.012
regulation of reactive oxygen species biosynthetic process GO:1903426 2 0.012
g protein coupled receptor signaling pathway GO:0007186 243 0.012
positive regulation of nervous system development GO:0051962 221 0.012
response to light stimulus GO:0009416 135 0.012
regulation of interleukin 8 production GO:0032677 3 0.012
regulation of protein localization GO:0032880 231 0.012
rho protein signal transduction GO:0007266 32 0.012
intracellular steroid hormone receptor signaling pathway GO:0030518 29 0.012
regulation of rna splicing GO:0043484 37 0.012
mrna processing GO:0006397 63 0.012
cellular response to growth factor stimulus GO:0071363 197 0.012
regulation of mrna splicing via spliceosome GO:0048024 32 0.012
cellular respiration GO:0045333 38 0.011
muscle system process GO:0003012 141 0.011
interleukin 8 production GO:0032637 4 0.011
regulation of system process GO:0044057 200 0.011
cellular response to cytokine stimulus GO:0071345 189 0.011
regulation of mitochondrial translation GO:0070129 3 0.011
ameboidal type cell migration GO:0001667 128 0.011
heart morphogenesis GO:0003007 178 0.011
regulation of reactive oxygen species metabolic process GO:2000377 40 0.011
heart contraction GO:0060047 93 0.011
myeloid leukocyte migration GO:0097529 57 0.011
cellular calcium ion homeostasis GO:0006874 119 0.011
single organism cell adhesion GO:0098602 156 0.011
regulation of actin filament based process GO:0032970 99 0.011
guanosine containing compound catabolic process GO:1901069 144 0.011
oxidative phosphorylation GO:0006119 14 0.011
cellular response to hormone stimulus GO:0032870 150 0.011
developmental growth involved in morphogenesis GO:0060560 138 0.011
response to reactive oxygen species GO:0000302 56 0.011
positive regulation of hydrolase activity GO:0051345 148 0.011
cofactor biosynthetic process GO:0051188 41 0.011
rna splicing GO:0008380 54 0.011
leukocyte activation involved in immune response GO:0002366 126 0.011
lipid biosynthetic process GO:0008610 179 0.011
regulation of lymphocyte activation GO:0051249 240 0.011
regulation of cell migration GO:0030334 219 0.011
regulation of cellular component biogenesis GO:0044087 181 0.011
pigment biosynthetic process GO:0046148 26 0.011
cellular response to lipid GO:0071396 145 0.011
development of primary sexual characteristics GO:0045137 143 0.011
gonad development GO:0008406 141 0.011
positive regulation of cell substrate adhesion GO:0010811 47 0.011
humoral immune response GO:0006959 57 0.011
negative regulation of phosphorylation GO:0042326 166 0.011
reactive oxygen species biosynthetic process GO:1903409 8 0.011
negative regulation of immune system process GO:0002683 209 0.011
meiosis i GO:0007127 60 0.011
protein localization to organelle GO:0033365 185 0.011
purine nucleoside monophosphate catabolic process GO:0009128 58 0.011
purine nucleotide biosynthetic process GO:0006164 65 0.011
response to inorganic substance GO:0010035 96 0.010
regulation of mapk cascade GO:0043408 248 0.010
negative regulation of phosphorus metabolic process GO:0010563 184 0.010
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.010
cellular divalent inorganic cation homeostasis GO:0072503 127 0.010
positive regulation of cell activation GO:0050867 158 0.010
nucleic acid phosphodiester bond hydrolysis GO:0090305 49 0.010
protein targeting GO:0006605 143 0.010
regulation of anatomical structure size GO:0090066 178 0.010
adaptive immune response GO:0002250 155 0.010
neural precursor cell proliferation GO:0061351 121 0.010
defense response to bacterium GO:0042742 119 0.010

Mthfd1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
nervous system disease DOID:863 0 0.040
disease of anatomical entity DOID:7 0 0.040
eye and adnexa disease DOID:1492 0 0.018
sensory system disease DOID:0050155 0 0.018
eye disease DOID:5614 0 0.017
central nervous system disease DOID:331 0 0.016
neurodegenerative disease DOID:1289 0 0.015
retinal degeneration DOID:8466 0 0.015
retinal disease DOID:5679 0 0.015
inherited metabolic disorder DOID:655 0 0.013
disease of metabolism DOID:0014667 0 0.013