Mus musculus

0 known processes

Nae1

NEDD8 activating enzyme E1 subunit 1

(Aliases: MGC29435,59kDa,MGC36437,MGC36630,Appbp1)

Nae1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.529
microtubule cytoskeleton organization GO:0000226 157 0.397
protein modification by small protein conjugation or removal GO:0070647 207 0.291
Yeast
microtubule based process GO:0007017 236 0.273
regulation of cell cycle process GO:0010564 160 0.236
carbohydrate derivative catabolic process GO:1901136 231 0.215
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.180
male gamete generation GO:0048232 285 0.168
mitotic cell cycle process GO:1903047 159 0.164
proteasomal protein catabolic process GO:0010498 98 0.157
dna repair GO:0006281 107 0.144
regulation of anatomical structure size GO:0090066 178 0.129
spermatid differentiation GO:0048515 115 0.128
protein localization to nuclear envelope GO:0090435 2 0.126
mitotic cell cycle GO:0000278 195 0.123
modification dependent protein catabolic process GO:0019941 133 0.120
cellular response to dna damage stimulus GO:0006974 207 0.118
regulation of cell cycle phase transition GO:1901987 77 0.117
dna damage checkpoint GO:0000077 26 0.110
cellular macromolecule catabolic process GO:0044265 206 0.099
purine containing compound catabolic process GO:0072523 213 0.098
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 61 0.097
glycosyl compound catabolic process GO:1901658 206 0.096
ribose phosphate metabolic process GO:0019693 291 0.096
organic cyclic compound catabolic process GO:1901361 295 0.092
nucleoside phosphate catabolic process GO:1901292 222 0.087
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.086
purine ribonucleotide metabolic process GO:0009150 290 0.084
regulation of ion transmembrane transport GO:0034765 119 0.083
regulation of cell cycle GO:0051726 281 0.082
stem cell development GO:0048864 219 0.080
modification dependent macromolecule catabolic process GO:0043632 133 0.078
synaptic transmission GO:0007268 329 0.078
nucleotide metabolic process GO:0009117 332 0.076
protein catabolic process GO:0030163 221 0.075
endomembrane system organization GO:0010256 147 0.075
cellular protein catabolic process GO:0044257 155 0.074
spermatogenesis GO:0007283 284 0.074
regulation of cell migration GO:0030334 219 0.074
ribonucleoside triphosphate catabolic process GO:0009203 199 0.072
regulation of cellular response to growth factor stimulus GO:0090287 82 0.072
dna integrity checkpoint GO:0031570 28 0.071
regulation of cellular component size GO:0032535 121 0.068
cell cycle checkpoint GO:0000075 47 0.066
purine nucleotide catabolic process GO:0006195 211 0.066
regulation of protein catabolic process GO:0042176 108 0.065
spermatid development GO:0007286 108 0.064
regulation of mitotic cell cycle phase transition GO:1901990 73 0.062
glycosyl compound metabolic process GO:1901657 246 0.061
nucleoside metabolic process GO:0009116 246 0.059
cell division GO:0051301 120 0.059
germ cell development GO:0007281 185 0.059
organelle localization GO:0051640 179 0.058
immune effector process GO:0002252 321 0.058
nucleoside phosphate metabolic process GO:0006753 338 0.057
ribonucleoside triphosphate metabolic process GO:0009199 220 0.056
protein modification by small protein conjugation GO:0032446 187 0.055
Yeast
purine ribonucleoside catabolic process GO:0046130 205 0.054
positive regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032436 23 0.054
macromolecule catabolic process GO:0009057 281 0.054
dna metabolic process GO:0006259 303 0.053
negative regulation of cell cycle GO:0045786 123 0.051
organonitrogen compound catabolic process GO:1901565 264 0.051
regulation of mitotic cell cycle GO:0007346 126 0.050
nucleoside triphosphate metabolic process GO:0009141 230 0.050
regulation of transmembrane transport GO:0034762 128 0.049
regulation of cellular catabolic process GO:0031329 242 0.048
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 56 0.047
ribonucleotide catabolic process GO:0009261 208 0.047
purine ribonucleoside metabolic process GO:0046128 241 0.046
negative regulation of cell cycle process GO:0010948 69 0.042
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.042
purine containing compound metabolic process GO:0072521 311 0.042
negative regulation of protein metabolic process GO:0051248 282 0.042
regulation of cell motility GO:2000145 236 0.041
positive regulation of cellular catabolic process GO:0031331 148 0.041
membrane organization GO:0061024 245 0.041
synapse organization GO:0050808 125 0.040
regulation of organelle organization GO:0033043 289 0.040
sperm individualization GO:0007291 1 0.039
oocyte construction GO:0007308 2 0.037
purine ribonucleotide catabolic process GO:0009154 208 0.037
positive regulation of hydrolase activity GO:0051345 148 0.036
stem cell differentiation GO:0048863 268 0.036
ribonucleoside catabolic process GO:0042454 206 0.036
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.035
nucleoside triphosphate catabolic process GO:0009143 205 0.035
establishment of organelle localization GO:0051656 122 0.035
heterocycle catabolic process GO:0046700 280 0.035
regulation of kinase activity GO:0043549 249 0.035
organelle assembly GO:0070925 177 0.035
negative regulation of cell cycle phase transition GO:1901988 48 0.035
purine nucleoside triphosphate catabolic process GO:0009146 203 0.033
negative regulation of mitotic cell cycle GO:0045930 58 0.033
axonogenesis GO:0007409 274 0.033
rna processing GO:0006396 105 0.033
ribonucleoside metabolic process GO:0009119 245 0.032
negative regulation of cellular component organization GO:0051129 194 0.032
double strand break repair GO:0006302 48 0.032
transmembrane transport GO:0055085 412 0.032
protein neddylation GO:0045116 1 0.032
Yeast
regulation of transforming growth factor beta receptor signaling pathway GO:0017015 43 0.032
ubiquitin dependent protein catabolic process GO:0006511 129 0.031
development of primary sexual characteristics GO:0045137 143 0.031
ion transmembrane transport GO:0034220 361 0.030
regulation of cell size GO:0008361 72 0.030
organophosphate catabolic process GO:0046434 232 0.030
organelle fission GO:0048285 170 0.029
transforming growth factor beta receptor signaling pathway GO:0007179 71 0.029
protein localization to organelle GO:0033365 185 0.029
ribonucleotide metabolic process GO:0009259 291 0.029
apoptotic signaling pathway GO:0097190 306 0.029
cellularization GO:0007349 1 0.028
regulation of proteasomal protein catabolic process GO:0061136 46 0.028
response to peptide GO:1901652 136 0.027
regulation of protein kinase activity GO:0045859 232 0.027
response to growth factor GO:0070848 198 0.027
regulation of synapse assembly GO:0051963 29 0.027
cardiac muscle contraction GO:0060048 32 0.026
response to light stimulus GO:0009416 135 0.026
cellular response to transforming growth factor beta stimulus GO:0071560 88 0.026
negative regulation of mitotic cell cycle phase transition GO:1901991 45 0.026
protein sumoylation GO:0016925 14 0.026
nucleotide catabolic process GO:0009166 217 0.025
dna recombination GO:0006310 92 0.025
regulation of cellular component biogenesis GO:0044087 181 0.025
g1 s transition of mitotic cell cycle GO:0000082 57 0.025
regulation of mapk cascade GO:0043408 248 0.024
positive regulation of cellular protein catabolic process GO:1903364 34 0.024
negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 26 0.024
negative regulation of cellular protein metabolic process GO:0032269 247 0.024
regulation of cell projection organization GO:0031344 206 0.024
negative regulation of phosphorus metabolic process GO:0010563 184 0.024
spindle organization GO:0007051 28 0.023
positive regulation of protein complex assembly GO:0031334 45 0.023
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 40 0.023
response to transforming growth factor beta GO:0071559 88 0.023
purine nucleotide metabolic process GO:0006163 302 0.023
regulation of vesicle mediated transport GO:0060627 139 0.023
regulation of cellular ketone metabolic process GO:0010565 66 0.023
mapk cascade GO:0000165 281 0.022
positive regulation of rna polymerase ii transcriptional preinitiation complex assembly GO:0045899 2 0.022
synaptonemal complex organization GO:0070193 15 0.022
cellular amino acid metabolic process GO:0006520 103 0.022
cellular amine metabolic process GO:0044106 44 0.021
regulation of response to dna damage stimulus GO:2001020 34 0.021
regulation of protein stability GO:0031647 52 0.021
single fertilization GO:0007338 82 0.021
nucleobase containing small molecule metabolic process GO:0055086 352 0.021
regulation of cellular amine metabolic process GO:0033238 20 0.021
regulation of binding GO:0051098 111 0.021
cation transport GO:0006812 399 0.021
guanosine containing compound metabolic process GO:1901068 144 0.021
regulation of transporter activity GO:0032409 57 0.021
positive regulation of protein catabolic process GO:0045732 60 0.021
negative regulation of synapse assembly GO:0051964 3 0.021
nucleus localization GO:0051647 20 0.021
positive regulation of dna templated transcription elongation GO:0032786 2 0.020
negative regulation of cell motility GO:2000146 61 0.020
negative regulation of intracellular signal transduction GO:1902532 167 0.020
body morphogenesis GO:0010171 45 0.020
regulation of nucleotide catabolic process GO:0030811 122 0.020
oocyte axis specification GO:0007309 2 0.020
peptidyl amino acid modification GO:0018193 336 0.019
positive regulation of atpase activity GO:0032781 3 0.019
methylation GO:0032259 134 0.019
cellular component assembly involved in morphogenesis GO:0010927 139 0.019
gonad development GO:0008406 141 0.019
regulation of cellular protein catabolic process GO:1903362 61 0.019
positive regulation of proteolysis GO:0045862 85 0.019
posttranscriptional regulation of gene expression GO:0010608 155 0.019
aromatic compound catabolic process GO:0019439 286 0.019
synaptic growth at neuromuscular junction GO:0051124 6 0.018
regulation of transferase activity GO:0051338 263 0.018
negative regulation of cell development GO:0010721 169 0.018
dendrite development GO:0016358 115 0.018
ras protein signal transduction GO:0007265 77 0.018
centrosome cycle GO:0007098 23 0.018
regulation of ras gtpase activity GO:0032318 88 0.017
positive regulation of transferase activity GO:0051347 167 0.017
negative regulation of phosphate metabolic process GO:0045936 184 0.017
nucleoside catabolic process GO:0009164 206 0.017
negative regulation of phosphorylation GO:0042326 166 0.017
nucleotide excision repair GO:0006289 13 0.017
cellular nitrogen compound catabolic process GO:0044270 280 0.017
regulation of ion transmembrane transporter activity GO:0032412 54 0.017
positive regulation of cell cycle process GO:0090068 61 0.017
muscle system process GO:0003012 141 0.017
cell cycle g1 s phase transition GO:0044843 57 0.017
multi organism behavior GO:0051705 62 0.017
response to organonitrogen compound GO:0010243 246 0.016
response to insulin GO:0032868 100 0.016
positive regulation of nucleotide metabolic process GO:0045981 114 0.016
positive regulation of nucleotide catabolic process GO:0030813 88 0.016
guanosine containing compound catabolic process GO:1901069 144 0.016
cellular response to growth factor stimulus GO:0071363 197 0.016
cellular ketone metabolic process GO:0042180 84 0.016
purine nucleoside catabolic process GO:0006152 205 0.016
positive regulation of protein phosphorylation GO:0001934 242 0.016
covalent chromatin modification GO:0016569 163 0.016
maternal determination of anterior posterior axis embryo GO:0008358 2 0.016
regulation of cellular response to stress GO:0080135 159 0.016
regulation of nucleotide metabolic process GO:0006140 169 0.015
atp metabolic process GO:0046034 75 0.015
nuclear division GO:0000280 158 0.015
actin mediated cell contraction GO:0070252 15 0.015
positive regulation of nucleoside metabolic process GO:0045979 91 0.015
cell maturation GO:0048469 127 0.015
purine nucleoside metabolic process GO:0042278 241 0.015
striated muscle tissue development GO:0014706 293 0.015
amine metabolic process GO:0009308 45 0.015
purine nucleoside monophosphate catabolic process GO:0009128 58 0.015
rna splicing GO:0008380 54 0.015
multicellular organismal protein catabolic process GO:0044254 1 0.015
small gtpase mediated signal transduction GO:0007264 97 0.014
negative regulation of cellular response to growth factor stimulus GO:0090288 46 0.014
protein ubiquitination GO:0016567 171 0.014
regulation of ion transport GO:0043269 215 0.014
muscle cell proliferation GO:0033002 52 0.014
endocytosis GO:0006897 168 0.014
meiotic cell cycle GO:0051321 122 0.013
regulation of protein localization GO:0032880 231 0.013
positive regulation of cellular component biogenesis GO:0044089 94 0.013
chemotaxis GO:0006935 247 0.013
tor signaling GO:0031929 21 0.013
neuron projection guidance GO:0097485 141 0.013
purine nucleoside monophosphate metabolic process GO:0009126 81 0.013
regulation of protein maturation GO:1903317 96 0.013
cation transmembrane transport GO:0098655 266 0.013
regulation of purine nucleotide catabolic process GO:0033121 122 0.012
mitotic cell cycle checkpoint GO:0007093 31 0.012
microtubule severing GO:0051013 5 0.012
negative regulation of pathway restricted smad protein phosphorylation GO:0060394 1 0.012
skeletal muscle cell differentiation GO:0035914 66 0.012
positive regulation of protein modification process GO:0031401 299 0.012
digestive system development GO:0055123 200 0.012
positive regulation of cellular amine metabolic process GO:0033240 5 0.012
response to radiation GO:0009314 165 0.012
positive regulation of protein kinase activity GO:0045860 144 0.012
purine nucleoside triphosphate metabolic process GO:0009144 226 0.012
stem cell division GO:0017145 30 0.011
gtp metabolic process GO:0046039 144 0.011
axon guidance GO:0007411 141 0.011
rho protein signal transduction GO:0007266 32 0.011
regulation of cell division GO:0051302 76 0.011
adult behavior GO:0030534 135 0.011
regulation of protein processing GO:0070613 96 0.011
multicellular organismal aging GO:0010259 24 0.011
purine ribonucleoside monophosphate catabolic process GO:0009169 57 0.011
stem cell maintenance GO:0019827 130 0.011
negative regulation of cellular catabolic process GO:0031330 47 0.011
negative regulation of nervous system development GO:0051961 156 0.011
cellular response to gonadotropin stimulus GO:0071371 4 0.011
cellular response to organonitrogen compound GO:0071417 145 0.011
establishment or maintenance of cell polarity GO:0007163 86 0.011
nucleocytoplasmic transport GO:0006913 139 0.011
lipid transport GO:0006869 98 0.010
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.010
digestive tract morphogenesis GO:0048546 147 0.010
regulation of epithelial cell proliferation GO:0050678 141 0.010
regulation of nuclear division GO:0051783 56 0.010
cognition GO:0050890 149 0.010
cytoplasmic transport GO:0016482 234 0.010
negative regulation of cell proliferation GO:0008285 296 0.010
regulation of neuron differentiation GO:0045664 281 0.010
trna processing GO:0008033 11 0.010
centrosome organization GO:0051297 26 0.010
mrna splicing via spliceosome GO:0000398 43 0.010
calcium ion transmembrane transport GO:0070588 85 0.010

Nae1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.022
nervous system disease DOID:863 0 0.022
physical disorder DOID:0080015 0 0.017
muscular disease DOID:0080000 0 0.014
musculoskeletal system disease DOID:17 0 0.014
muscle tissue disease DOID:66 0 0.014
myopathy DOID:423 0 0.012
muscular dystrophy DOID:9884 0 0.012
limb girdle muscular dystrophy DOID:11724 0 0.012
sensory system disease DOID:0050155 0 0.010
eye and adnexa disease DOID:1492 0 0.010
eye disease DOID:5614 0 0.010