Mus musculus

155 known processes

Nf2

neurofibromatosis 2

(Aliases: merlin)

Nf2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
negative regulation of kinase activity GO:0033673 81 0.903
negative regulation of phosphorylation GO:0042326 166 0.868
negative regulation of tor signaling GO:0032007 13 0.865
negative regulation of cell size GO:0045792 3 0.797
negative regulation of molecular function GO:0044092 258 0.797
nuclear transport GO:0051169 139 0.780
negative regulation of protein serine threonine kinase activity GO:0071901 49 0.772
negative regulation of cellular protein metabolic process GO:0032269 247 0.750
negative regulation of protein modification process GO:0031400 163 0.726
cytoplasmic transport GO:0016482 234 0.724
regulation of hydrolase activity GO:0051336 246 0.710
regulation of kinase activity GO:0043549 249 0.671
negative regulation of protein phosphorylation GO:0001933 126 0.666
negative regulation of intracellular signal transduction GO:1902532 167 0.664
regulation of transferase activity GO:0051338 263 0.662
cell growth GO:0016049 130 0.653
Rat Fly
negative regulation of insulin receptor signaling pathway GO:0046627 14 0.645
regulation of protein kinase activity GO:0045859 232 0.636
plasma membrane organization GO:0007009 90 0.621
Fly
intracellular protein transport GO:0006886 204 0.600
negative regulation of cell proliferation GO:0008285 296 0.596
regulation of actin cytoskeleton organization GO:0032956 84 0.594
Human
nucleocytoplasmic transport GO:0006913 139 0.594
regulation of tor signaling GO:0032006 17 0.590
protein localization to nucleus GO:0034504 121 0.583
regulation of cell adhesion GO:0030155 154 0.578
Human
regulation of protein serine threonine kinase activity GO:0071900 157 0.573
negative regulation of organ growth GO:0046621 17 0.538
Fly
negative regulation of map kinase activity GO:0043407 34 0.538
cellular response to dna damage stimulus GO:0006974 207 0.507
positive regulation of nucleotide catabolic process GO:0030813 88 0.506
negative regulation of phosphorus metabolic process GO:0010563 184 0.493
positive regulation of cell adhesion GO:0045785 80 0.493
negative regulation of protein metabolic process GO:0051248 282 0.491
lateral inhibition GO:0046331 1 0.490
protein targeting GO:0006605 143 0.485
gtp catabolic process GO:0006184 143 0.472
organ growth GO:0035265 117 0.470
Fly
regulation of protein localization GO:0032880 231 0.465
negative regulation of synapse assembly GO:0051964 3 0.458
protein transport into membrane raft GO:0032596 4 0.456
regulation of stress fiber assembly GO:0051492 15 0.455
Human
regulation of ras gtpase activity GO:0032318 88 0.451
protein localization to organelle GO:0033365 185 0.447
apoptotic signaling pathway GO:0097190 306 0.438
membrane organization GO:0061024 245 0.436
Fly
positive regulation of ras gtpase activity GO:0032320 65 0.422
negative regulation of phosphate metabolic process GO:0045936 184 0.418
cell substrate adhesion GO:0031589 130 0.415
digestive tract morphogenesis GO:0048546 147 0.411
regulation of gtp catabolic process GO:0033124 113 0.406
single organism nuclear import GO:1902593 95 0.388
nucleoside phosphate metabolic process GO:0006753 338 0.370
regulation of purine nucleotide metabolic process GO:1900542 169 0.365
action potential GO:0001508 78 0.364
guanosine containing compound catabolic process GO:1901069 144 0.361
regulation of cell growth GO:0001558 91 0.360
Rat Fly
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.356
negative regulation of epithelial cell proliferation GO:0050680 64 0.350
epithelial tube morphogenesis GO:0060562 303 0.347
protein import GO:0017038 101 0.338
striated muscle tissue development GO:0014706 293 0.336
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.331
epithelial cell proliferation GO:0050673 174 0.330
mapk cascade GO:0000165 281 0.329
ras protein signal transduction GO:0007265 77 0.325
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.325
positive regulation of rho gtpase activity GO:0032321 41 0.320
guanosine containing compound metabolic process GO:1901068 144 0.319
skeletal system development GO:0001501 356 0.318
positive regulation of nucleoside metabolic process GO:0045979 91 0.316
synapse organization GO:0050808 125 0.313
digestive system development GO:0055123 200 0.313
regulation of ras protein signal transduction GO:0046578 114 0.313
small gtpase mediated signal transduction GO:0007264 97 0.310
regulation of nucleotide metabolic process GO:0006140 169 0.309
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902043 13 0.308
nucleoside metabolic process GO:0009116 246 0.305
positive regulation of gtpase activity GO:0043547 85 0.305
rho protein signal transduction GO:0007266 32 0.297
oocyte differentiation GO:0009994 35 0.290
Fly
rna localization GO:0006403 23 0.288
Fly
organonitrogen compound catabolic process GO:1901565 264 0.287
female gamete generation GO:0007292 74 0.286
Fly
engulfment of apoptotic cell GO:0043652 3 0.286
dephosphorylation GO:0016311 129 0.283
actin cytoskeleton organization GO:0030036 220 0.280
Human
positive regulation of autophagy GO:0010508 9 0.280
oogenesis GO:0048477 56 0.275
Fly
regulation of cell substrate adhesion GO:0010810 73 0.275
regulation of mapk cascade GO:0043408 248 0.272
regulation of cellular catabolic process GO:0031329 242 0.271
developmental maturation GO:0021700 193 0.270
Fly
negative regulation of wnt signaling pathway GO:0030178 73 0.270
chemotaxis GO:0006935 247 0.269
heterocycle catabolic process GO:0046700 280 0.269
purine ribonucleotide metabolic process GO:0009150 290 0.269
regulation of organelle organization GO:0033043 289 0.268
Human
nucleotide metabolic process GO:0009117 332 0.263
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.261
regulation of cell size GO:0008361 72 0.260
positive regulation of gtp catabolic process GO:0033126 85 0.259
negative regulation of growth GO:0045926 99 0.259
Rat Fly
wnt signaling pathway GO:0016055 188 0.258
negative regulation of transferase activity GO:0051348 85 0.258
cell cell junction organization GO:0045216 72 0.254
positive regulation of nucleotide metabolic process GO:0045981 114 0.254
establishment of organelle localization GO:0051656 122 0.252
regulation of nucleocytoplasmic transport GO:0046822 73 0.251
digestive tract development GO:0048565 190 0.250
gastrulation GO:0007369 116 0.247
regulation of insulin receptor signaling pathway GO:0046626 21 0.247
lymphocyte differentiation GO:0030098 242 0.246
regulation of cell cycle GO:0051726 281 0.245
Fly
cellular lipid metabolic process GO:0044255 323 0.245
regulation of nucleotide catabolic process GO:0030811 122 0.242
protein import into nucleus GO:0006606 95 0.238
regulation of autophagy GO:0010506 30 0.238
response to light stimulus GO:0009416 135 0.237
glycosyl compound metabolic process GO:1901657 246 0.237
embryonic epithelial tube formation GO:0001838 130 0.236
gtp metabolic process GO:0046039 144 0.236
regulation of actin filament based process GO:0032970 99 0.233
Human
myelination GO:0042552 74 0.232
cellular response to peptide hormone stimulus GO:0071375 92 0.231
striated muscle cell development GO:0055002 125 0.229
regulation of epithelial cell proliferation GO:0050678 141 0.227
limbic system development GO:0021761 72 0.227
schwann cell proliferation GO:0014010 2 0.227
Human
nucleobase containing small molecule metabolic process GO:0055086 352 0.226
germ cell development GO:0007281 185 0.222
Fly
carbohydrate derivative catabolic process GO:1901136 231 0.220
canonical wnt signaling pathway involved in negative regulation of apoptotic process GO:0044336 4 0.219
attachment of spindle microtubules to kinetochore GO:0008608 4 0.219
nuclear import GO:0051170 95 0.216
transmission of nerve impulse GO:0019226 76 0.214
positive regulation of purine nucleotide catabolic process GO:0033123 88 0.211
muscle cell differentiation GO:0042692 261 0.211
negative regulation of cellular response to insulin stimulus GO:1900077 16 0.211
establishment of rna localization GO:0051236 18 0.211
oocyte anterior posterior axis specification GO:0007314 2 0.210
Fly
ribonucleoside catabolic process GO:0042454 206 0.209
establishment of protein localization to organelle GO:0072594 118 0.206
nucleoside triphosphate metabolic process GO:0009141 230 0.204
axon ensheathment GO:0008366 76 0.202
regulation of reactive oxygen species metabolic process GO:2000377 40 0.202
purine nucleotide metabolic process GO:0006163 302 0.202
regulation of protein stability GO:0031647 52 0.201
positive regulation of cellular catabolic process GO:0031331 148 0.200
formation of primary germ layer GO:0001704 77 0.199
cell junction organization GO:0034330 77 0.199
cell junction assembly GO:0034329 52 0.197
regulation of cytoskeleton organization GO:0051493 122 0.196
Human
fatty acid metabolic process GO:0006631 121 0.196
cation transport GO:0006812 399 0.196
regulation of rho protein signal transduction GO:0035023 71 0.195
regulation of protein import into nucleus GO:0042306 52 0.194
establishment or maintenance of cell polarity GO:0007163 86 0.192
Mouse
protein maturation GO:0051604 176 0.192
regulation of rho gtpase activity GO:0032319 58 0.191
cell adhesion GO:0007155 329 0.189
Human
response to organonitrogen compound GO:0010243 246 0.188
protein homooligomerization GO:0051260 43 0.187
positive regulation of hydrolase activity GO:0051345 148 0.187
purine nucleotide catabolic process GO:0006195 211 0.185
pole plasm assembly GO:0007315 2 0.184
Fly
cell growth involved in cardiac muscle cell development GO:0061049 3 0.181
oocyte axis specification GO:0007309 2 0.181
Fly
monocarboxylic acid metabolic process GO:0032787 191 0.179
actin filament bundle assembly GO:0051017 40 0.176
Human
ribonucleoside triphosphate catabolic process GO:0009203 199 0.175
smoothened signaling pathway GO:0007224 105 0.175
regulation of apoptotic signaling pathway GO:2001233 197 0.174
establishment of protein localization to membrane GO:0090150 54 0.173
ribonucleoside metabolic process GO:0009119 245 0.172
male gamete generation GO:0048232 285 0.171
Fly
regulation of wnt signaling pathway GO:0030111 123 0.169
negative regulation of cell growth GO:0030308 44 0.166
Rat
regulation of anatomical structure size GO:0090066 178 0.166
regulation of cellular component size GO:0032535 121 0.165
nucleoside phosphate catabolic process GO:1901292 222 0.165
organelle fission GO:0048285 170 0.163
Fly
purine nucleoside triphosphate metabolic process GO:0009144 226 0.162
regulation of map kinase activity GO:0043405 120 0.162
regulation of cellular amine metabolic process GO:0033238 20 0.162
endocytosis GO:0006897 168 0.161
Mouse Fly
embryonic skeletal system development GO:0048706 120 0.158
lymphocyte homeostasis GO:0002260 64 0.158
tor signaling GO:0031929 21 0.157
urogenital system development GO:0001655 261 0.156
regulation of vesicle mediated transport GO:0060627 139 0.156
negative regulation of mapk cascade GO:0043409 65 0.156
ensheathment of neurons GO:0007272 76 0.154
morphogenesis of embryonic epithelium GO:0016331 159 0.154
cellular nitrogen compound catabolic process GO:0044270 280 0.151
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 16 0.150
cilium morphogenesis GO:0060271 102 0.150
neuronal action potential GO:0019228 54 0.150
regulation of protein localization to nucleus GO:1900180 60 0.149
nucleotide catabolic process GO:0009166 217 0.147
kidney development GO:0001822 213 0.147
negative regulation of cyclin dependent protein serine threonine kinase activity GO:0045736 9 0.146
cellular response to peptide GO:1901653 92 0.146
cellular response to growth factor stimulus GO:0071363 197 0.143
regulation of cellular component biogenesis GO:0044087 181 0.142
Human
purine nucleoside triphosphate catabolic process GO:0009146 203 0.141
organic cyclic compound catabolic process GO:1901361 295 0.140
cardiac muscle tissue development GO:0048738 130 0.140
response to insulin GO:0032868 100 0.139
ribonucleotide metabolic process GO:0009259 291 0.139
ribose phosphate metabolic process GO:0019693 291 0.139
regulation of intracellular protein transport GO:0033157 82 0.136
neural tube development GO:0021915 160 0.136
purine containing compound metabolic process GO:0072521 311 0.136
mesoderm development GO:0007498 100 0.135
purine ribonucleoside catabolic process GO:0046130 205 0.134
purine nucleoside catabolic process GO:0006152 205 0.133
regulation of proteolysis GO:0030162 164 0.131
purine ribonucleotide catabolic process GO:0009154 208 0.131
regulation of protein targeting GO:1903533 61 0.131
neural tube formation GO:0001841 108 0.130
autophagy GO:0006914 45 0.130
negative regulation of cell cycle GO:0045786 123 0.128
Fly
protein modification by small protein conjugation or removal GO:0070647 207 0.128
purine nucleoside metabolic process GO:0042278 241 0.127
cerebral cortex development GO:0021987 86 0.127
nuclear export GO:0051168 34 0.126
insulin receptor signaling pathway GO:0008286 49 0.126
cell cycle arrest GO:0007050 37 0.124
Fly
myeloid cell differentiation GO:0030099 233 0.123
tube closure GO:0060606 91 0.123
regulation of mitotic cell cycle GO:0007346 126 0.123
potassium ion transport GO:0006813 52 0.123
negative regulation of nervous system development GO:0051961 156 0.122
Fly
glucose import GO:0046323 32 0.119
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.119
purine containing compound catabolic process GO:0072523 213 0.118
protein oligomerization GO:0051259 67 0.117
protein processing GO:0016485 163 0.117
positive regulation of organelle organization GO:0010638 128 0.117
Human
signal transduction in absence of ligand GO:0038034 55 0.117
cellular response to organonitrogen compound GO:0071417 145 0.117
actin filament organization GO:0007015 113 0.117
Human
establishment or maintenance of cytoskeleton polarity GO:0030952 2 0.117
single organismal cell cell adhesion GO:0016337 131 0.116
Human
purine ribonucleoside metabolic process GO:0046128 241 0.115
reactive oxygen species metabolic process GO:0072593 84 0.114
single organism cell adhesion GO:0098602 156 0.114
Human
axon guidance GO:0007411 141 0.114
intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 35 0.113
regulation of nucleoside metabolic process GO:0009118 130 0.113
protein transport within lipid bilayer GO:0032594 5 0.112
response to peptide GO:1901652 136 0.112
cellular response to insulin stimulus GO:0032869 78 0.110
actomyosin structure organization GO:0031032 56 0.110
Human
glucose transport GO:0015758 56 0.110
response to radiation GO:0009314 165 0.109
stem cell development GO:0048864 219 0.108
regulation of leukocyte differentiation GO:1902105 159 0.108
phagocytosis GO:0006909 66 0.107
homeostasis of number of cells GO:0048872 210 0.107
positive regulation of mitotic sister chromatid separation GO:1901970 2 0.107
cardiocyte differentiation GO:0035051 87 0.106
neural tube closure GO:0001843 90 0.105
developmental cell growth GO:0048588 84 0.105
regulation of protein transport GO:0051223 163 0.103
purine nucleotide biosynthetic process GO:0006164 65 0.103
ribonucleotide catabolic process GO:0009261 208 0.102
cellular response to decreased oxygen levels GO:0036294 18 0.102
oxidation reduction process GO:0055114 342 0.102
mitotic g1 dna damage checkpoint GO:0031571 4 0.102
activation of rho gtpase activity GO:0032862 7 0.101
cell cell signaling involved in cell fate commitment GO:0045168 35 0.098
carbohydrate transport GO:0008643 62 0.094
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.094
response to peptide hormone GO:0043434 127 0.094
tube formation GO:0035148 140 0.092
regulation of endocytosis GO:0030100 69 0.092
ossification GO:0001503 216 0.092
regulation of multi organism process GO:0043900 111 0.091
canonical wnt signaling pathway involved in positive regulation of apoptotic process GO:0044337 3 0.091
branching morphogenesis of an epithelial tube GO:0048754 159 0.091
mitotic cell cycle GO:0000278 195 0.090
negative regulation of leukocyte differentiation GO:1902106 51 0.090
blood vessel morphogenesis GO:0048514 285 0.090
extrinsic apoptotic signaling pathway GO:0097191 126 0.089
angiogenesis GO:0001525 201 0.089
microtubule cytoskeleton organization GO:0000226 157 0.088
organophosphate catabolic process GO:0046434 232 0.088
directional locomotion GO:0033058 3 0.088
stem cell differentiation GO:0048863 268 0.088
muscle cell development GO:0055001 133 0.087
nucleoside catabolic process GO:0009164 206 0.087
oocyte maturation GO:0001556 18 0.087
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.087
signal transduction involved in mitotic dna damage checkpoint GO:1902402 3 0.087
determination of adult lifespan GO:0008340 11 0.087
myeloid leukocyte differentiation GO:0002573 119 0.087
negative regulation of apoptotic signaling pathway GO:2001234 104 0.086
mesoderm formation GO:0001707 62 0.085
protein export from nucleus GO:0006611 20 0.084
axonogenesis GO:0007409 274 0.084
response to oxygen levels GO:0070482 62 0.083
renal system development GO:0072001 225 0.082
hippocampus development GO:0021766 52 0.082
regulation of protein processing GO:0070613 96 0.082
activation of ras gtpase activity GO:0032856 11 0.082
ubiquitin dependent protein catabolic process GO:0006511 129 0.081
epithelial tube formation GO:0072175 130 0.081
hindbrain development GO:0030902 128 0.081
cellular response to oxygen levels GO:0071453 20 0.080
regulation of cytoplasmic transport GO:1903649 112 0.080
regulation of intracellular transport GO:0032386 159 0.080
modification dependent protein catabolic process GO:0019941 133 0.079
carbohydrate metabolic process GO:0005975 230 0.079
regulation of canonical wnt signaling pathway GO:0060828 82 0.079
macromolecule catabolic process GO:0009057 281 0.077
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.075
cellular ketone metabolic process GO:0042180 84 0.075
nitrogen compound transport GO:0071705 271 0.075
response to nutrient levels GO:0031667 109 0.075
cellular component assembly involved in morphogenesis GO:0010927 139 0.074
cellular amine metabolic process GO:0044106 44 0.074
adherens junction organization GO:0034332 28 0.074
cellular amino acid metabolic process GO:0006520 103 0.074
nucleoside triphosphate catabolic process GO:0009143 205 0.074
primary neural tube formation GO:0014020 95 0.073
posttranscriptional regulation of gene expression GO:0010608 155 0.073
respiratory system development GO:0060541 190 0.073
cellular carbohydrate metabolic process GO:0044262 119 0.073
cellular response to hormone stimulus GO:0032870 150 0.072
muscle tissue development GO:0060537 308 0.071
organelle assembly GO:0070925 177 0.070
establishment of protein localization to plasma membrane GO:0090002 34 0.070
multicellular organismal signaling GO:0035637 91 0.070
regulation of phosphoprotein phosphatase activity GO:0043666 3 0.070
negative regulation of protein kinase b signaling GO:0051898 18 0.070
positive regulation of rap gtpase activity GO:0032854 3 0.069
activation of adenylate cyclase activity GO:0007190 4 0.069
negative regulation of odontogenesis GO:0042483 3 0.068
t cell differentiation GO:0030217 174 0.067
skin development GO:0043588 220 0.067
positive regulation of nucleocytoplasmic transport GO:0046824 30 0.066
canonical wnt signaling pathway involved in heart development GO:0061316 3 0.066
negative regulation of vasculature development GO:1901343 26 0.066
negative regulation of protein processing GO:0010955 79 0.065
methylation GO:0032259 134 0.065
response to decreased oxygen levels GO:0036293 59 0.065
positive regulation of cell development GO:0010720 237 0.065
insulin like growth factor receptor signaling pathway GO:0048009 21 0.065
negative regulation of cellular component organization GO:0051129 194 0.064
cell fate commitment GO:0045165 210 0.063
protein heterooligomerization GO:0051291 14 0.063
positive regulation of chromosome segregation GO:0051984 4 0.062
response to extracellular stimulus GO:0009991 127 0.061
telencephalon development GO:0021537 186 0.061
dna metabolic process GO:0006259 303 0.061
Human
negative regulation of mitotic cell cycle GO:0045930 58 0.061
regulation of myeloid cell differentiation GO:0045637 96 0.061
regulation of t cell activation GO:0050863 170 0.061
negative regulation of cell development GO:0010721 169 0.060
Fly
nucleic acid transport GO:0050657 18 0.060
maintenance of location GO:0051235 89 0.060
myelination in peripheral nervous system GO:0022011 19 0.060
mitochondrion organization GO:0007005 134 0.059
positive regulation of cell cycle GO:0045787 92 0.059
morphogenesis of a branching structure GO:0001763 203 0.059
positive regulation of cell proliferation involved in heart valve morphogenesis GO:0003251 1 0.059
aromatic compound catabolic process GO:0019439 286 0.059
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 45 0.059
genetic imprinting GO:0071514 27 0.058
central nervous system neuron differentiation GO:0021953 162 0.058
regionalization GO:0003002 337 0.058
Fly
heparan sulfate proteoglycan biosynthetic process GO:0015012 8 0.058
sulfur compound biosynthetic process GO:0044272 37 0.057
regulation of osteoclast differentiation GO:0045670 36 0.057
regulation of cell cycle process GO:0010564 160 0.057
response to hypoxia GO:0001666 58 0.057
neuron projection guidance GO:0097485 141 0.057
protein kinase b signaling GO:0043491 74 0.057
positive regulation of cellular component biogenesis GO:0044089 94 0.056
Human
negative regulation of transcription involved in g1 s transition of mitotic cell cycle GO:0071930 1 0.056
organophosphate biosynthetic process GO:0090407 122 0.056
positive regulation of protein phosphorylation GO:0001934 242 0.056
Fly
positive regulation of cellular amine metabolic process GO:0033240 5 0.056
positive regulation of cell substrate adhesion GO:0010811 47 0.056
metaphase anaphase transition of mitotic cell cycle GO:0007091 9 0.055
pallium development GO:0021543 120 0.055
cohesin localization to chromatin GO:0071921 1 0.055
morphogenesis of a branching epithelium GO:0061138 193 0.055
cellular homeostasis GO:0019725 240 0.055
regulation of myeloid leukocyte differentiation GO:0002761 58 0.054
organelle localization GO:0051640 179 0.054
positive chemotaxis GO:0050918 18 0.054
cellular macromolecule catabolic process GO:0044265 206 0.054
phosphatidylinositol mediated signaling GO:0048015 41 0.054
forebrain development GO:0030900 302 0.054
negative regulation of ras protein signal transduction GO:0046580 18 0.054
positive regulation of leukocyte differentiation GO:1902107 86 0.054
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 40 0.053
positive regulation of programmed cell death GO:0043068 218 0.053
germ line stem cell division GO:0042078 2 0.053
response to growth factor GO:0070848 198 0.053
histone h4 k16 acetylation GO:0043984 3 0.053
regulation of chromosome organization GO:0033044 83 0.052
regulation of attachment of spindle microtubules to kinetochore GO:0051988 3 0.052
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.051
Fly
cardiac muscle cell differentiation GO:0055007 69 0.051
mesoderm morphogenesis GO:0048332 64 0.051
regulation of establishment of protein localization GO:0070201 181 0.051
dna damage response signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 3 0.051
negative regulation of immune system process GO:0002683 209 0.050
plasma membrane long chain fatty acid transport GO:0015911 1 0.050
adherens junction assembly GO:0034333 22 0.050
regulation of transcription involved in g1 s transition of mitotic cell cycle GO:0000083 3 0.050
skeletal system morphogenesis GO:0048705 203 0.050
glycosyl compound catabolic process GO:1901658 206 0.050
spermatid differentiation GO:0048515 115 0.050
Fly
positive regulation of epithelial cell proliferation GO:0050679 68 0.050
locomotory behavior GO:0007626 195 0.049
negative regulation of myeloid leukocyte differentiation GO:0002762 20 0.049
macromolecule methylation GO:0043414 120 0.049
inflammatory response GO:0006954 244 0.049
protein catabolic process GO:0030163 221 0.049
regulation of cell migration GO:0030334 219 0.049
ribonucleoside triphosphate metabolic process GO:0009199 220 0.049
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.048
dna damage response signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 2 0.048
regulation of cell growth involved in cardiac muscle cell development GO:0061050 3 0.048
regulation of inositol 1 4 5 trisphosphate sensitive calcium release channel activity GO:0031585 2 0.048
epithelial cell development GO:0002064 159 0.048
formation of radial glial scaffolds GO:0021943 4 0.047
negative regulation of cell growth involved in cardiac muscle cell development GO:0061052 2 0.047
regulation of ossification GO:0030278 112 0.047
positive regulation of proteolysis GO:0045862 85 0.047
trachea development GO:0060438 18 0.047
maternal determination of anterior posterior axis embryo GO:0008358 2 0.047
Fly
regulation of transmembrane transport GO:0034762 128 0.047
regulation of endopeptidase activity GO:0052548 89 0.047
regulation of mitosis GO:0007088 29 0.047
hindbrain radial glia guided cell migration GO:0021932 12 0.047
negative regulation of fibroblast migration GO:0010764 2 0.047
negative regulation of cellular catabolic process GO:0031330 47 0.046
positive regulation of apoptotic process GO:0043065 217 0.046
body morphogenesis GO:0010171 45 0.046
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 55 0.046
endomembrane system organization GO:0010256 147 0.046
Fly
synaptic growth at neuromuscular junction GO:0051124 6 0.046
g1 s transition of mitotic cell cycle GO:0000082 57 0.045
carbohydrate biosynthetic process GO:0016051 74 0.045
signal transduction involved in dna damage checkpoint GO:0072422 3 0.045
organonitrogen compound biosynthetic process GO:1901566 192 0.045
regulation of lymphocyte proliferation GO:0050670 117 0.044
regulation of dephosphorylation GO:0035303 18 0.044
olfactory lobe development GO:0021988 32 0.044
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.044
gland development GO:0048732 330 0.044
nucleobase containing compound transport GO:0015931 27 0.044
photoreceptor cell morphogenesis GO:0008594 3 0.043
embryonic appendage morphogenesis GO:0035113 126 0.043
blastoderm segmentation GO:0007350 13 0.043
Fly
dna alkylation GO:0006305 43 0.043
jnk cascade GO:0007254 72 0.043
regulation of camp biosynthetic process GO:0030817 25 0.043
regulation of protein maturation GO:1903317 96 0.043
t cell activation GO:0042110 289 0.043
exocytosis GO:0006887 121 0.042
cell substrate adherens junction assembly GO:0007045 19 0.042
regulation of cell motility GO:2000145 236 0.042
anatomical structure homeostasis GO:0060249 145 0.042
regulation of peptidase activity GO:0052547 96 0.042
trachea morphogenesis GO:0060439 8 0.042
cellular response to hypoxia GO:0071456 17 0.042
sprouting angiogenesis GO:0002040 26 0.042
mitotic sister chromatid separation GO:0051306 9 0.042
negative regulation of ossification GO:0030279 49 0.042
regulation of system process GO:0044057 200 0.042
regulation of protein complex assembly GO:0043254 83 0.042

Nf2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 0 0.924
Human
cancer DOID:162 0 0.675
Human
organ system cancer DOID:0050686 0 0.675
Human
endocrine gland cancer DOID:170 0 0.320
large intestine cancer DOID:5672 0 0.214
colon cancer DOID:219 0 0.214
gastrointestinal system cancer DOID:3119 0 0.214
intestinal cancer DOID:10155 0 0.214
colorectal cancer DOID:9256 0 0.214
bone disease DOID:0080001 0 0.079
disease of anatomical entity DOID:7 0 0.079
musculoskeletal system disease DOID:17 0 0.079
connective tissue disease DOID:65 0 0.079
liver carcinoma DOID:686 0 0.075
liver cancer DOID:3571 0 0.075
colon carcinoma DOID:1520 0 0.057
thoracic cancer DOID:5093 0 0.052