Mus musculus

120 known processes

Nfkb1

nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105

(Aliases: NF-KB1,p105,NF-kappaB1,NF-kappaB,p50/p105,p50)

Nfkb1 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
nucleotide binding oligomerization domain containing signaling pathway GO:0070423 6 1.000
cytoplasmic pattern recognition receptor signaling pathway GO:0002753 10 1.000
marginal zone b cell differentiation GO:0002315 2 1.000
activation of innate immune response GO:0002218 56 1.000
toll like receptor 4 signaling pathway GO:0034142 9 1.000
positive regulation of antimicrobial peptide biosynthetic process GO:0002807 1 1.000
Fly
regulation of defense response to fungus GO:1900150 1 1.000
Fly
regulation of antimicrobial humoral response GO:0002759 3 1.000
Fly
nucleotide binding oligomerization domain containing 1 signaling pathway GO:0070427 5 1.000
antimicrobial peptide production GO:0002775 2 1.000
Fly
antimicrobial peptide biosynthetic process GO:0002777 2 1.000
Fly
cellular response to molecule of bacterial origin GO:0071219 83 1.000
Human Mouse
toll like receptor signaling pathway GO:0002224 38 1.000
i kappab kinase nf kappab signaling GO:0007249 85 0.999
Mouse
innate immune response activating signal transduction GO:0002758 50 0.999
negative regulation of tumor necrosis factor biosynthetic process GO:0042536 1 0.999
germinal center formation GO:0002467 16 0.999
Mouse
response to muramyl dipeptide GO:0032495 9 0.999
Mouse
nucleotide binding oligomerization domain containing 2 signaling pathway GO:0070431 6 0.999
positive regulation of antimicrobial peptide production GO:0002225 1 0.999
Fly
cellular response to lipopolysaccharide GO:0071222 77 0.999
Human Mouse
regulation of antimicrobial peptide production GO:0002784 1 0.999
Fly
follicular dendritic cell differentiation GO:0002268 2 0.998
Mouse
immune response regulating signaling pathway GO:0002764 125 0.998
regulation of defense response to virus by host GO:0050691 8 0.998
Fly
pattern recognition receptor signaling pathway GO:0002221 47 0.998
t helper 1 type immune response GO:0042088 25 0.998
Mouse
immune response activating signal transduction GO:0002757 116 0.997
alpha beta t cell differentiation GO:0046632 69 0.997
Mouse
t helper cell differentiation GO:0042093 28 0.997
Mouse
interleukin 12 biosynthetic process GO:0042090 8 0.997
positive regulation of innate immune response GO:0045089 80 0.996
Fly
regulation of innate immune response GO:0045088 91 0.996
Fly
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.996
Mouse
myeloid dendritic cell differentiation GO:0043011 16 0.994
Mouse
activation of immune response GO:0002253 138 0.993
regulation of antimicrobial peptide biosynthetic process GO:0002805 1 0.992
Fly
cd4 positive alpha beta t cell activation GO:0035710 45 0.991
Mouse
alpha beta t cell differentiation involved in immune response GO:0002293 30 0.991
Mouse
cytokine mediated signaling pathway GO:0019221 115 0.989
lipopolysaccharide mediated signaling pathway GO:0031663 25 0.989
negative regulation of defense response GO:0031348 77 0.987
cellular response to biotic stimulus GO:0071216 92 0.987
Human Mouse
defense response to fungus GO:0050832 12 0.986
Fly
cd4 positive alpha beta t cell differentiation GO:0043367 41 0.985
Mouse
circadian regulation of gene expression GO:0032922 48 0.985
Mouse
regulation of tumor necrosis factor production GO:0032680 49 0.983
peptide biosynthetic process GO:0043043 11 0.983
Fly
nik nf kappab signaling GO:0038061 14 0.982
Mouse
follicular dendritic cell activation GO:0002266 2 0.981
Mouse
positive regulation of cytokine production GO:0001819 174 0.979
Mouse
regulation of cellular amine metabolic process GO:0033238 20 0.979
positive regulation of production of molecular mediator of immune response GO:0002702 45 0.978
Fly
positive regulation of nf kappab transcription factor activity GO:0051092 30 0.977
Mouse
tumor necrosis factor superfamily cytokine production GO:0071706 51 0.977
cd4 positive alpha beta t cell differentiation involved in immune response GO:0002294 28 0.976
Mouse
cellular amine metabolic process GO:0044106 44 0.974
regulation of interleukin 10 biosynthetic process GO:0045074 1 0.973
tumor necrosis factor production GO:0032640 50 0.971
regulation of defense response GO:0031347 233 0.970
negative regulation of myeloid cell differentiation GO:0045638 38 0.968
lymphocyte activation involved in immune response GO:0002285 93 0.967
Mouse
cytokine biosynthetic process GO:0042089 68 0.966
antibacterial peptide production GO:0002778 2 0.964
Fly
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.963
Mouse
negative regulation of cytokine biosynthetic process GO:0042036 13 0.963
regulation of lymphocyte activation GO:0051249 240 0.962
regulation of cytokine production GO:0001817 266 0.961
response to molecule of bacterial origin GO:0002237 143 0.957
Human Mouse
t helper 2 cell differentiation GO:0045064 12 0.957
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 68 0.957
Mouse
b cell differentiation GO:0030183 78 0.957
myeloid dendritic cell activation GO:0001773 25 0.954
Mouse
t cell activation GO:0042110 289 0.953
Mouse
adaptive immune response GO:0002250 155 0.951
Mouse
negative regulation of cytokine production GO:0001818 84 0.950
cellular amino acid metabolic process GO:0006520 103 0.947
extracellular structure organization GO:0043062 148 0.946
Mouse
response to lipopolysaccharide GO:0032496 128 0.945
Human Mouse
regulation of tumor necrosis factor superfamily cytokine production GO:1903555 50 0.945
regulation of defense response to bacterium GO:1900424 3 0.943
Fly
positive regulation of defense response GO:0031349 124 0.943
Fly
lymphocyte differentiation GO:0030098 242 0.942
Mouse
defense response to bacterium GO:0042742 119 0.940
Fly
cell activation involved in immune response GO:0002263 126 0.940
Mouse
cellular response to cytokine stimulus GO:0071345 189 0.940
Human
cellular response to lipid GO:0071396 145 0.938
Human Mouse
protein import into nucleus translocation GO:0000060 12 0.938
regulation of cytokine biosynthetic process GO:0042035 59 0.938
regulation of production of molecular mediator of immune response GO:0002700 65 0.937
Fly
dendritic cell differentiation GO:0097028 26 0.937
Mouse
positive regulation of cytokine biosynthetic process GO:0042108 40 0.935
Mouse
positive regulation of interleukin 10 biosynthetic process GO:0045082 1 0.934
positive regulation of interferon gamma production GO:0032729 39 0.934
defense response to protozoan GO:0042832 25 0.933
negative regulation of interleukin 12 production GO:0032695 10 0.930
extracellular matrix organization GO:0030198 147 0.927
Mouse
leukocyte differentiation GO:0002521 342 0.927
Mouse
negative regulation of interleukin 12 biosynthetic process GO:0045083 1 0.926
b cell activation GO:0042113 161 0.924
positive regulation of interleukin 12 production GO:0032735 21 0.923
Mouse
interleukin 10 biosynthetic process GO:0042091 1 0.923
extrinsic apoptotic signaling pathway GO:0097191 126 0.923
Mouse
cytokine production GO:0001816 319 0.921
apoptotic signaling pathway GO:0097190 306 0.920
Mouse
protein localization to nucleus GO:0034504 121 0.919
humoral immune response GO:0006959 57 0.918
Fly
regionalization GO:0003002 337 0.912
t cell differentiation GO:0030217 174 0.912
Mouse
cytokine metabolic process GO:0042107 71 0.912
regulation of humoral immune response GO:0002920 22 0.906
Fly
immunoglobulin mediated immune response GO:0016064 69 0.906
skin development GO:0043588 220 0.904
Mouse
b cell activation involved in immune response GO:0002312 50 0.895
regulation of antibacterial peptide biosynthetic process GO:0002808 1 0.895
Fly
circadian rhythm GO:0007623 114 0.894
Mouse
regulation of tumor necrosis factor biosynthetic process GO:0042534 10 0.885
antibacterial peptide biosynthetic process GO:0002780 2 0.883
Fly
negative regulation of protein metabolic process GO:0051248 282 0.877
myeloid cell differentiation GO:0030099 233 0.873
Mouse
positive regulation of defense response to virus by host GO:0002230 6 0.872
Fly
regulation of leukocyte differentiation GO:1902105 159 0.871
response to dsrna GO:0043331 30 0.870
regulation of interleukin 10 production GO:0032653 21 0.862
myeloid leukocyte activation GO:0002274 83 0.860
Mouse
t cell differentiation involved in immune response GO:0002292 30 0.853
Mouse
regulation of cellular amino acid metabolic process GO:0006521 5 0.852
regulation of b cell activation GO:0050864 81 0.850
inflammatory response GO:0006954 244 0.849
spleen development GO:0048536 39 0.845
Mouse
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.844
Mouse
negative regulation of immune system process GO:0002683 209 0.843
regulation of interleukin 12 biosynthetic process GO:0045075 8 0.835
cellular response to peptide GO:1901653 92 0.834
Human
leukocyte mediated immunity GO:0002443 174 0.831
antigen processing and presentation GO:0019882 47 0.829
Mouse
leukocyte activation involved in immune response GO:0002366 126 0.821
Mouse
rhythmic process GO:0048511 174 0.819
Mouse
interspecies interaction between organisms GO:0044419 83 0.816
regulation of apoptotic signaling pathway GO:2001233 197 0.815
Mouse
positive regulation of antimicrobial humoral response GO:0002760 2 0.814
Fly
amine metabolic process GO:0009308 45 0.813
regulation of toll like receptor signaling pathway GO:0034121 20 0.811
positive regulation of programmed cell death GO:0043068 218 0.811
regulation of antibacterial peptide production GO:0002786 1 0.810
Fly
negative regulation of protein catabolic process GO:0042177 36 0.809
Mouse
regulation of leukocyte proliferation GO:0070663 121 0.807
intracellular receptor signaling pathway GO:0030522 74 0.803
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 57 0.802
myeloid leukocyte differentiation GO:0002573 119 0.793
Mouse
response to organonitrogen compound GO:0010243 246 0.785
Human Mouse
type i interferon signaling pathway GO:0060337 10 0.785
innate immune response GO:0045087 157 0.784
Fly
negative regulation of apoptotic signaling pathway GO:2001234 104 0.775
Mouse
reactive oxygen species biosynthetic process GO:1903409 8 0.773
cellular response to type i interferon GO:0071357 10 0.770
antibacterial humoral response GO:0019731 8 0.746
Fly
response to peptide GO:1901652 136 0.737
Human Mouse
positive regulation of leukocyte apoptotic process GO:2000108 21 0.722
negative regulation of inflammatory response GO:0050728 61 0.717
t cell activation involved in immune response GO:0002286 43 0.712
Mouse
regulation of defense response to virus GO:0050688 18 0.706
Fly
interferon gamma production GO:0032609 67 0.693
production of molecular mediator of immune response GO:0002440 103 0.688
Fly
interleukin 12 production GO:0032615 32 0.687
cell fate commitment GO:0045165 210 0.677
regulation of interleukin 12 production GO:0032655 30 0.676
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 61 0.670
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 40 0.661
nucleotide binding domain leucine rich repeat containing receptor signaling pathway GO:0035872 6 0.661
apical constriction GO:0003383 4 0.660
t helper 1 cell differentiation GO:0045063 13 0.656
Mouse
response to protozoan GO:0001562 28 0.642
negative regulation of protein modification process GO:0031400 163 0.641
negative regulation of cell activation GO:0050866 111 0.639
protein targeting GO:0006605 143 0.632
response to interleukin 1 GO:0070555 11 0.631
Human
regulation of stress activated mapk cascade GO:0032872 69 0.631
negative regulation of molecular function GO:0044092 258 0.621
Human
tumor necrosis factor biosynthetic process GO:0042533 10 0.618
regulation of protein transport GO:0051223 163 0.602
regulation of transcription factor import into nucleus GO:0042990 24 0.600
immune effector process GO:0002252 321 0.595
Mouse Fly
positive regulation of protein modification process GO:0031401 299 0.592
leukocyte apoptotic process GO:0071887 71 0.585
negative regulation of t helper 2 cell differentiation GO:0045629 4 0.585
regulation of type i interferon mediated signaling pathway GO:0060338 7 0.579
myd88 dependent toll like receptor signaling pathway GO:0002755 7 0.568
hair cycle GO:0042633 90 0.564
Mouse
positive regulation of cell death GO:0010942 224 0.552
regulation of t cell differentiation GO:0045580 83 0.552
regulation of multi organism process GO:0043900 111 0.550
Fly
positive regulation of mirna metabolic process GO:2000630 1 0.549
Human
regulation of binding GO:0051098 111 0.548
negative regulation of toll like receptor signaling pathway GO:0034122 14 0.541
cell type specific apoptotic process GO:0097285 268 0.533
cellular response to tumor necrosis factor GO:0071356 21 0.529
regulation of cell activation GO:0050865 289 0.527
positive regulation of interleukin 10 production GO:0032733 12 0.526
cellular response to dna damage stimulus GO:0006974 207 0.524
Fly
liver development GO:0001889 66 0.524
Mouse
protein catabolic process GO:0030163 221 0.523
Mouse
alpha beta t cell activation GO:0046631 91 0.521
Mouse
negative regulation of nf kappab transcription factor activity GO:0032088 15 0.521
regulation of response to biotic stimulus GO:0002831 38 0.517
Fly
regulation of tyrosine phosphorylation of stat5 protein GO:0042522 8 0.516
positive regulation of interferon alpha production GO:0032727 4 0.506
regulation of t helper 1 cell differentiation GO:0045625 7 0.504
interleukin 10 production GO:0032613 23 0.504
keratinocyte differentiation GO:0030216 48 0.499
regulation of protein localization GO:0032880 231 0.498
regulation of protein localization to nucleus GO:1900180 60 0.496
growth involved in symbiotic interaction GO:0044110 23 0.494
positive regulation of cellular amine metabolic process GO:0033240 5 0.492
negative regulation of t helper 1 cell differentiation GO:0045626 3 0.491
lymphocyte mediated immunity GO:0002449 139 0.486
somatic diversification of immunoglobulins involved in immune response GO:0002208 36 0.484
positive regulation of glial cell proliferation GO:0060252 4 0.484
alpha beta t cell activation involved in immune response GO:0002287 31 0.479
Mouse
negative regulation of tumor necrosis factor production GO:0032720 17 0.475
regulation of growth of symbiont in host GO:0044126 19 0.474
regulation of interferon gamma production GO:0032649 57 0.474
stress activated mapk cascade GO:0051403 80 0.473
regulation of mirna metabolic process GO:2000628 4 0.471
Human
regulation of t cell activation GO:0050863 170 0.470
regulation of intracellular protein transport GO:0033157 82 0.468
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 45 0.466
Mouse
regulation of sterol transport GO:0032371 17 0.462
regulation of mapk cascade GO:0043408 248 0.457
peptidyl tyrosine phosphorylation GO:0018108 143 0.456
macrophage derived foam cell differentiation GO:0010742 6 0.443
nucleocytoplasmic transport GO:0006913 139 0.440
positive regulation of growth hormone receptor signaling pathway GO:0060399 3 0.439
digestive system development GO:0055123 200 0.429
positive regulation of cholesterol transport GO:0032376 9 0.425
regulation of cellular amide metabolic process GO:0034248 10 0.423
Fly
t cell differentiation in thymus GO:0033077 77 0.422
glial cell apoptotic process GO:0034349 3 0.414
tumor necrosis factor mediated signaling pathway GO:0033209 13 0.410
positive regulation of translational initiation GO:0045948 4 0.404
regulation of cytokine production involved in immune response GO:0002718 26 0.400
regulation of cholesterol transport GO:0032374 17 0.400
regulation of protein targeting GO:1903533 61 0.399
regulation of cellular ketone metabolic process GO:0010565 66 0.399
regulation of alpha beta t cell proliferation GO:0046640 18 0.383
epidermis development GO:0008544 187 0.382
Mouse
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 87 0.377
jak stat cascade involved in growth hormone signaling pathway GO:0060397 4 0.377
positive regulation of defense response to bacterium GO:1900426 1 0.376
Fly
negative regulation of innate immune response GO:0045824 17 0.374
type i interferon production GO:0032606 29 0.374
myd88 independent toll like receptor signaling pathway GO:0002756 3 0.364
regulation of cell cycle GO:0051726 281 0.360
regulation of myeloid cell differentiation GO:0045637 96 0.356
t cell apoptotic process GO:0070231 39 0.354
positive regulation of type i interferon production GO:0032481 14 0.349
erk1 and erk2 cascade GO:0070371 77 0.347
regulation of reactive oxygen species biosynthetic process GO:1903426 2 0.346
regulation of interferon beta biosynthetic process GO:0045357 4 0.342
cytokine production involved in immune response GO:0002367 34 0.335
macromolecule catabolic process GO:0009057 281 0.333
Mouse
negative regulation of inflammatory response to antigenic stimulus GO:0002862 10 0.333
osteoclast proliferation GO:0002158 4 0.332
positive regulation of apoptotic signaling pathway GO:2001235 95 0.329
regulation of cytoplasmic transport GO:1903649 112 0.325
positive regulation of leukocyte proliferation GO:0070665 73 0.324
hair follicle development GO:0001942 85 0.323
Mouse
protein import into nucleus GO:0006606 95 0.321
negative regulation of tumor necrosis factor superfamily cytokine production GO:1903556 17 0.320
regulation of map kinase activity GO:0043405 120 0.319
positive regulation of response to biotic stimulus GO:0002833 15 0.313
Fly
positive regulation of transcription initiation from rna polymerase ii promoter GO:0060261 5 0.307
cellular response to organonitrogen compound GO:0071417 145 0.307
Human
germ cell development GO:0007281 185 0.306
regulation of protein catabolic process GO:0042176 108 0.302
Mouse
positive regulation of interleukin 12 biosynthetic process GO:0045084 6 0.300
Mouse
b cell mediated immunity GO:0019724 71 0.300
negative regulation of cell proliferation GO:0008285 296 0.291
Fly
cellular ketone metabolic process GO:0042180 84 0.291
defense response to other organism GO:0098542 197 0.290
Fly
positive regulation of jnk cascade GO:0046330 46 0.290
sterol transport GO:0015918 38 0.290
ribose phosphate metabolic process GO:0019693 291 0.286
anion transport GO:0006820 177 0.284
positive regulation of cellular amide metabolic process GO:0034250 5 0.280
Fly
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.279
negative regulation of mast cell proliferation GO:0070667 1 0.279
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.277
negative regulation of cytokine production involved in immune response GO:0002719 5 0.276
regulation of inflammatory response GO:0050727 147 0.271
immune response inhibiting signal transduction GO:0002765 4 0.270
regulation of nitric oxide biosynthetic process GO:0045428 18 0.269
Fly
immunoglobulin secretion GO:0048305 17 0.269
regulation of myd88 independent toll like receptor signaling pathway GO:0034127 1 0.268
epithelial cell proliferation GO:0050673 174 0.265
interleukin 4 mediated signaling pathway GO:0035771 2 0.265
necroptotic signaling pathway GO:0097527 3 0.265
gastrulation GO:0007369 116 0.261
regulation of peptide transport GO:0090087 91 0.258
positive regulation of cell activation GO:0050867 158 0.255
cytoplasmic transport GO:0016482 234 0.252
interferon beta biosynthetic process GO:0045350 4 0.246
cellular amide metabolic process GO:0043603 58 0.245
Fly
response to peptide hormone GO:0043434 127 0.243
Human
amide transport GO:0042886 138 0.241
purine ribonucleoside metabolic process GO:0046128 241 0.239
interleukin 10 secretion GO:0072608 4 0.238
necroptotic process GO:0070266 21 0.237
regulation of response to wounding GO:1903034 189 0.236
humoral immune response mediated by circulating immunoglobulin GO:0002455 14 0.236
t cell receptor signaling pathway GO:0050852 46 0.235
mature b cell differentiation involved in immune response GO:0002313 9 0.232
lymphocyte proliferation GO:0046651 164 0.226
positive regulation of lymphocyte activation GO:0051251 140 0.224
regulation of lymphocyte differentiation GO:0045619 107 0.221
compound eye development GO:0048749 1 0.220
regulation of establishment of protein localization GO:0070201 181 0.219
b cell proliferation GO:0042100 53 0.218
organonitrogen compound biosynthetic process GO:1901566 192 0.218
Human Fly
defense response to virus GO:0051607 68 0.216
Fly
cellular response to organic cyclic compound GO:0071407 87 0.216
Human
cytokine secretion GO:0050663 72 0.215
negative regulation of growth GO:0045926 99 0.215
interleukin 5 secretion GO:0072603 2 0.213
single organism nuclear import GO:1902593 95 0.212
response to light stimulus GO:0009416 135 0.209
interferon gamma mediated signaling pathway GO:0060333 5 0.207
positive regulation of t cell differentiation GO:0045582 52 0.206
activation of janus kinase activity GO:0042976 2 0.206
actin cytoskeleton organization GO:0030036 220 0.204
protein localization to organelle GO:0033365 185 0.202
muscle cell development GO:0055001 133 0.202
positive regulation of jak stat cascade GO:0046427 22 0.200
nuclear transport GO:0051169 139 0.197
regulation of type 2 immune response GO:0002828 18 0.197
regulation of peptidyl tyrosine phosphorylation GO:0050730 93 0.197
regulation of nucleocytoplasmic transport GO:0046822 73 0.196
growth of symbiont in host GO:0044117 23 0.195
regulation of proteolysis GO:0030162 164 0.191
intracellular steroid hormone receptor signaling pathway GO:0030518 29 0.190
protein import GO:0017038 101 0.190
positive regulation of lipid transport GO:0032370 22 0.188
positive regulation of t helper 1 cell differentiation GO:0045627 4 0.187
response to tumor necrosis factor GO:0034612 26 0.186
regulation of jnk cascade GO:0046328 62 0.185
negative regulation of transcription factor import into nucleus GO:0042992 13 0.184
regulation of lipid storage GO:0010883 20 0.184
negative regulation of lymphocyte activation GO:0051250 91 0.183
ensheathment of neurons GO:0007272 76 0.181
alpha beta t cell proliferation GO:0046633 21 0.179
negative regulation of intracellular protein transport GO:0090317 27 0.179
cholesterol efflux GO:0033344 24 0.178
response to exogenous dsrna GO:0043330 22 0.174
regulation of membrane potential GO:0042391 192 0.174
reactive nitrogen species metabolic process GO:2001057 0 0.170
regulation of intracellular transport GO:0032386 159 0.170
negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 23 0.169
response to type i interferon GO:0034340 12 0.168
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.167
neural tube development GO:0021915 160 0.166
regulation of lymphocyte proliferation GO:0050670 117 0.163
positive regulation of proteolysis GO:0045862 85 0.162
positive regulation of endopeptidase activity GO:0010950 43 0.160
regulation of kinase activity GO:0043549 249 0.158
gland development GO:0048732 330 0.158
Mouse
notch signaling pathway GO:0007219 71 0.155
positive regulation of antibacterial peptide production GO:0002803 1 0.155
Fly
regulation of dendritic cell cytokine production GO:0002730 2 0.150
somatic recombination of immunoglobulin genes involved in immune response GO:0002204 36 0.150
defense response to gram negative bacterium GO:0050829 28 0.150
Fly
chromatin modification GO:0016568 187 0.148
osteoclast differentiation GO:0030316 62 0.148
positive regulation of type i interferon mediated signaling pathway GO:0060340 4 0.147
regulation of myd88 dependent toll like receptor signaling pathway GO:0034124 2 0.147
positive regulation of map kinase activity GO:0043406 84 0.146
regulation of jun kinase activity GO:0043506 40 0.146
mirna metabolic process GO:0010586 10 0.146
Human
transcription factor import into nucleus GO:0042991 26 0.145
multicellular organismal homeostasis GO:0048871 164 0.144
wnt signaling pathway GO:0016055 188 0.143
Human
intrinsic apoptotic signaling pathway GO:0097193 132 0.141
sensory organ morphogenesis GO:0090596 242 0.141
positive regulation of b cell activation GO:0050871 49 0.141
positive regulation of peptidase activity GO:0010952 49 0.135
stem cell proliferation GO:0072089 117 0.135
Fly
interleukin 8 production GO:0032637 4 0.134
positive regulation of chronic inflammatory response GO:0002678 4 0.133
dna recombination GO:0006310 92 0.132
negative regulation of interleukin 5 production GO:0032714 4 0.131
regulation of tyrosine phosphorylation of stat1 protein GO:0042510 2 0.131
mature b cell differentiation GO:0002335 13 0.131
regulation of jak stat cascade GO:0046425 34 0.129
positive regulation of osteoclast differentiation GO:0045672 15 0.129
t cell homeostasis GO:0043029 35 0.128
positive regulation of dendritic cell apoptotic process GO:2000670 3 0.128
regulation of gliogenesis GO:0014013 50 0.126
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 55 0.124
gonad development GO:0008406 141 0.123
immune response regulating cell surface receptor signaling pathway GO:0002768 80 0.123
regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathway GO:2001267 4 0.123
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 62 0.123
peptide transport GO:0015833 133 0.122
regulation of dendritic cell apoptotic process GO:2000668 3 0.121
chromatin organization GO:0006325 206 0.120
regulation of wnt signaling pathway GO:0030111 123 0.120
Human
ruffle organization GO:0031529 16 0.120
erythrocyte differentiation GO:0030218 88 0.119
regulation of activation of jak2 kinase activity GO:0010534 1 0.118
protein modification by small protein conjugation GO:0032446 187 0.118
t cell migration GO:0072678 19 0.116
positive regulation of t cell activation GO:0050870 101 0.115
negative regulation of interferon beta biosynthetic process GO:0045358 1 0.113
interferon beta production GO:0032608 16 0.113
negative regulation of phosphate metabolic process GO:0045936 184 0.112
regulation of interleukin 6 production GO:0032675 55 0.112
regulation of reactive oxygen species metabolic process GO:2000377 40 0.112
regulation of toll like receptor 2 signaling pathway GO:0034135 3 0.112
type 2 immune response GO:0042092 23 0.112
positive regulation of regulatory t cell differentiation GO:0045591 4 0.111
regulation of protein kinase activity GO:0045859 232 0.111
positive regulation of protein kinase b signaling GO:0051897 32 0.110
peptide metabolic process GO:0006518 46 0.109
Fly
regulation of b cell proliferation GO:0030888 39 0.108
positive regulation of tyrosine phosphorylation of stat protein GO:0042531 15 0.108
protein autophosphorylation GO:0046777 61 0.107
response to organic cyclic compound GO:0014070 198 0.106
Human
negative regulation of growth of symbiont in host GO:0044130 19 0.106
positive regulation of hydrolase activity GO:0051345 148 0.106
activation of mapkkk activity GO:0000185 1 0.105
negative regulation of t cell differentiation GO:0045581 23 0.105
toll like receptor 2 signaling pathway GO:0034134 6 0.105
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 34 0.105
positive regulation of response to cytokine stimulus GO:0060760 11 0.104
negative regulation of adaptive immune response GO:0002820 25 0.103
protein maturation GO:0051604 176 0.103
tyrosine phosphorylation of stat5 protein GO:0042506 9 0.102
negative regulation of regulatory t cell differentiation GO:0045590 2 0.102
regulation of interleukin 8 production GO:0032677 3 0.101
response to uv b GO:0010224 5 0.100
regulation of toll like receptor 4 signaling pathway GO:0034143 4 0.100
regulation of osteoblast differentiation GO:0045667 67 0.100
programmed necrotic cell death GO:0097300 28 0.100
digestive tract morphogenesis GO:0048546 147 0.100
lymphocyte apoptotic process GO:0070227 54 0.100
cellularization GO:0007349 1 0.100
regulation of b cell differentiation GO:0045577 23 0.099
divalent inorganic cation transport GO:0072511 178 0.098
lymph node development GO:0048535 18 0.097
positive regulation of isotype switching GO:0045830 15 0.096
regulation of t helper 1 type immune response GO:0002825 17 0.096
positive regulation of translational initiation by iron GO:0045994 2 0.095
negative regulation of leukocyte proliferation GO:0070664 46 0.095
response to nicotine GO:0035094 6 0.095
Human
regulation of canonical wnt signaling pathway GO:0060828 82 0.094
Human
organic hydroxy compound transport GO:0015850 93 0.094
regulation of ion transport GO:0043269 215 0.094
regulation of interleukin 5 secretion GO:2000662 2 0.092
histone modification GO:0016570 159 0.092
regulation of macrophage differentiation GO:0045649 9 0.092
antigen receptor mediated signaling pathway GO:0050851 64 0.092
dendritic cell cytokine production GO:0002371 3 0.092
tyrosine phosphorylation of stat protein GO:0007260 23 0.091
regulation of myeloid leukocyte differentiation GO:0002761 58 0.091
negative regulation of macrophage derived foam cell differentiation GO:0010745 1 0.091
respiratory tube development GO:0030323 167 0.090
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 27 0.090
cd4 positive cd25 positive alpha beta regulatory t cell differentiation GO:0002361 4 0.090
response to uv GO:0009411 44 0.089
regulation of mast cell differentiation GO:0060375 3 0.088
establishment of protein localization to organelle GO:0072594 118 0.088
regulation of lipid transport GO:0032368 36 0.088
exocrine system development GO:0035272 45 0.087
peptidyl serine phosphorylation GO:0018105 74 0.086
t cell mediated immunity GO:0002456 50 0.085
odontogenesis GO:0042476 78 0.085
immune response activating cell surface receptor signaling pathway GO:0002429 72 0.085
positive regulation of multi organism process GO:0043902 26 0.085
Fly
nitrogen compound transport GO:0071705 271 0.085
epithelial tube morphogenesis GO:0060562 303 0.084
regulation of protein complex assembly GO:0043254 83 0.084
peptidyl amino acid modification GO:0018193 336 0.084
morphogenesis of a branching epithelium GO:0061138 193 0.083

Nfkb1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.485
disease of cellular proliferation DOID:14566 0 0.485
immune system disease DOID:2914 0 0.373
disease of anatomical entity DOID:7 0 0.373
hematopoietic system disease DOID:74 0 0.373
primary immunodeficiency disease DOID:612 0 0.298
blood protein disease DOID:620 0 0.298
agammaglobulinemia DOID:2583 0 0.298
common variable immunodeficiency DOID:12177 0 0.298
b cell deficiency DOID:2115 0 0.298
organ system cancer DOID:0050686 0 0.244
bone remodeling disease DOID:0080005 0 0.147
bone disease DOID:0080001 0 0.147
osteopetrosis DOID:13533 0 0.147
musculoskeletal system disease DOID:17 0 0.147
connective tissue disease DOID:65 0 0.147
osteosclerosis DOID:4254 0 0.147