Mus musculus

217 known processes

Nkx2-1

NK2 homeobox 1

(Aliases: Titf1,Nkx2.1,AV026640,Ttf-1,T/EBP)

Nkx2-1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
embryonic skeletal system development GO:0048706 120 0.992
Mouse
paraxial mesodermal cell differentiation GO:0048342 2 0.987
paraxial mesodermal cell fate commitment GO:0048343 2 0.979
lung development GO:0030324 164 0.977
respiratory system development GO:0060541 190 0.975
ureteric bud morphogenesis GO:0060675 62 0.971
respiratory tube development GO:0030323 167 0.970
lung morphogenesis GO:0060425 50 0.970
Human
epithelial tube morphogenesis GO:0060562 303 0.966
Human Mouse
bmp signaling pathway GO:0030509 93 0.965
Mouse
nephron epithelium morphogenesis GO:0072088 68 0.956
pallium development GO:0021543 120 0.954
embryonic organ morphogenesis GO:0048562 276 0.952
Mouse
glandular epithelial cell differentiation GO:0002067 38 0.950
Mouse
kidney development GO:0001822 213 0.950
endocrine system development GO:0035270 98 0.949
telencephalon development GO:0021537 186 0.949
nephron tubule morphogenesis GO:0072078 68 0.949
carbon catabolite activation of transcription GO:0045991 4 0.948
central nervous system neuron differentiation GO:0021953 162 0.947
lung cell differentiation GO:0060479 30 0.947
regionalization GO:0003002 337 0.944
embryonic skeletal system morphogenesis GO:0048704 91 0.936
forebrain cell migration GO:0021885 58 0.930
palate development GO:0060021 76 0.924
mesenchyme development GO:0060485 152 0.915
Human Mouse
columnar cuboidal epithelial cell differentiation GO:0002065 82 0.914
Mouse
cerebral cortex cell migration GO:0021795 44 0.914
morphogenesis of a branching epithelium GO:0061138 193 0.910
Human
urogenital system development GO:0001655 261 0.909
regulation of organ morphogenesis GO:2000027 144 0.907
neural tube patterning GO:0021532 43 0.903
appendage morphogenesis GO:0035107 149 0.901
lacrimal gland development GO:0032808 5 0.896
cardiac muscle cell proliferation GO:0060038 31 0.883
Mouse
renal tubule development GO:0061326 87 0.870
ureteric bud development GO:0001657 94 0.865
lung epithelial cell differentiation GO:0060487 29 0.861
carbon catabolite repression of transcription from rna polymerase ii promoter GO:0000437 1 0.853
hair follicle morphogenesis GO:0031069 29 0.852
gonad development GO:0008406 141 0.850
neuron fate specification GO:0048665 30 0.848
Mouse
regulation of stem cell proliferation GO:0072091 78 0.847
pituitary gland development GO:0021983 38 0.846
lung epithelium development GO:0060428 37 0.845
branching morphogenesis of an epithelial tube GO:0048754 159 0.844
Human
regulation of transcription from rna polymerase iii promoter GO:0006359 2 0.836
renal tubule morphogenesis GO:0061333 72 0.830
regulation of neuron differentiation GO:0045664 281 0.828
Mouse
paraxial mesoderm morphogenesis GO:0048340 10 0.821
carbon catabolite activation of transcription from rna polymerase ii promoter GO:0000436 4 0.818
positive regulation of bmp signaling pathway GO:0030513 23 0.796
stem cell development GO:0048864 219 0.796
Human
appendage development GO:0048736 166 0.790
forebrain neuron differentiation GO:0021879 52 0.787
cell fate commitment GO:0045165 210 0.785
positive regulation of stem cell proliferation GO:2000648 59 0.782
neural tube development GO:0021915 160 0.780
cerebral cortex radially oriented cell migration GO:0021799 31 0.780
embryonic viscerocranium morphogenesis GO:0048703 8 0.779
ear morphogenesis GO:0042471 118 0.778
Mouse
regulation of organ growth GO:0046620 61 0.776
Mouse
nephron development GO:0072006 109 0.776
blood vessel remodeling GO:0001974 33 0.767
positive regulation of neuron differentiation GO:0045666 141 0.762
Mouse
pancreas development GO:0031016 57 0.757
Mouse
neuron projection guidance GO:0097485 141 0.755
mesonephric tubule development GO:0072164 94 0.753
positive regulation of transcription by glucose GO:0046016 3 0.751
negative regulation of cell fate specification GO:0009996 4 0.739
regulation of neural precursor cell proliferation GO:2000177 70 0.737
regulation of cell cycle GO:0051726 281 0.735
nephron tubule development GO:0072080 84 0.733
carbon catabolite regulation of transcription GO:0045990 4 0.730
digestive tract morphogenesis GO:0048546 147 0.730
Mouse
epithelial tube branching involved in lung morphogenesis GO:0060441 28 0.727
Human
dorsal ventral neural tube patterning GO:0021904 28 0.725
formation of primary germ layer GO:0001704 77 0.723
striated muscle tissue development GO:0014706 293 0.720
Mouse
pharynx development GO:0060465 1 0.718
angiogenesis GO:0001525 201 0.718
cardiac chamber morphogenesis GO:0003206 93 0.716
Mouse
regulation of cell migration involved in sprouting angiogenesis GO:0090049 4 0.714
pyramidal neuron migration GO:0021852 1 0.707
locomotory behavior GO:0007626 195 0.706
placenta development GO:0001890 140 0.704
regulation of cardiac muscle tissue growth GO:0055021 26 0.702
Mouse
mesonephric tubule morphogenesis GO:0072171 63 0.700
prostate gland morphogenesis GO:0060512 32 0.699
segmentation GO:0035282 93 0.698
nephron epithelium development GO:0072009 92 0.695
positive regulation of smoothened signaling pathway GO:0045880 23 0.694
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.694
Mouse
epithelial cell differentiation involved in prostate gland development GO:0060742 13 0.691
cellular amino acid metabolic process GO:0006520 103 0.690
female sex differentiation GO:0046660 84 0.685
Rat
cell fate commitment involved in formation of primary germ layer GO:0060795 26 0.685
neural precursor cell proliferation GO:0061351 121 0.682
skeletal system morphogenesis GO:0048705 203 0.679
Mouse
epithelial mesenchymal signaling involved in prostate gland development GO:0060738 2 0.675
thyroid stimulating hormone secreting cell differentiation GO:0060129 4 0.675
regulation of epithelial cell proliferation GO:0050678 141 0.673
Mouse
positive regulation of growth GO:0045927 104 0.670
forebrain development GO:0030900 302 0.669
gland development GO:0048732 330 0.669
branching involved in ureteric bud morphogenesis GO:0001658 56 0.667
positive regulation of transcription from rna polymerase ii promoter by glucose GO:0000432 3 0.666
central nervous system neuron development GO:0021954 67 0.661
positive regulation of neural precursor cell proliferation GO:2000179 42 0.657
morphogenesis of a branching structure GO:0001763 203 0.653
Human
glomerulus development GO:0032835 40 0.652
nephron morphogenesis GO:0072028 69 0.650
granulosa cell differentiation GO:0060014 1 0.646
organ growth GO:0035265 117 0.642
Mouse
mesonephric epithelium development GO:0072163 94 0.629
stem cell differentiation GO:0048863 268 0.628
Human Mouse
digestive system development GO:0055123 200 0.623
Mouse
mesoderm development GO:0007498 100 0.622
limb development GO:0060173 166 0.621
epithelial cell proliferation GO:0050673 174 0.620
Mouse
thymus development GO:0048538 41 0.620
stem cell proliferation GO:0072089 117 0.620
regulation of bmp signaling pathway GO:0030510 60 0.618
lung alveolus development GO:0048286 45 0.617
secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development GO:0060528 4 0.613
glomerular mesangial cell differentiation GO:0072008 3 0.611
semicircular canal fusion GO:0060879 1 0.609
mesenchyme morphogenesis GO:0072132 32 0.604
gastrulation GO:0007369 116 0.603
regulation of stem cell differentiation GO:2000736 50 0.603
Human Mouse
positive regulation of cell development GO:0010720 237 0.602
Mouse
mesangial cell differentiation GO:0072007 4 0.602
chemotaxis GO:0006935 247 0.600
kidney vasculature development GO:0061440 15 0.581
kidney morphogenesis GO:0060993 83 0.578
cardiac muscle tissue growth GO:0055017 37 0.573
Mouse
neuron migration GO:0001764 122 0.572
skeletal system development GO:0001501 356 0.571
Mouse
chromatin modification GO:0016568 187 0.570
muscle tissue development GO:0060537 308 0.565
Mouse
lens morphogenesis in camera type eye GO:0002089 24 0.565
neuroendocrine cell differentiation GO:0061101 7 0.564
bronchiole development GO:0060435 3 0.563
ovarian follicle development GO:0001541 40 0.561
positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090100 43 0.558
carbon catabolite regulation of transcription from rna polymerase ii promoter GO:0000429 4 0.553
forebrain generation of neurons GO:0021872 63 0.538
ameboidal type cell migration GO:0001667 128 0.538
vascular endothelial growth factor receptor signaling pathway GO:0048010 24 0.535
extracellular matrix organization GO:0030198 147 0.534
positive regulation of epithelial cell proliferation GO:0050679 68 0.531
regulation of vascular wound healing GO:0061043 2 0.531
axon guidance GO:0007411 141 0.529
mesonephros development GO:0001823 97 0.524
mesodermal cell differentiation GO:0048333 22 0.523
lung pattern specification process GO:0060432 1 0.522
regulation of mesenchymal cell proliferation GO:0010464 37 0.522
molting cycle GO:0042303 90 0.518
positive regulation of transcription from rna polymerase iii promoter GO:0045945 1 0.512
notch signaling pathway GO:0007219 71 0.512
cerebral cortex radial glia guided migration GO:0021801 17 0.510
mammary gland bud morphogenesis GO:0060648 4 0.509
mesoderm morphogenesis GO:0048332 64 0.509
epidermis development GO:0008544 187 0.508
carbohydrate metabolic process GO:0005975 230 0.507
circulatory system process GO:0003013 197 0.507
Mouse Rat
cardiac ventricle morphogenesis GO:0003208 50 0.504
Mouse
sensory organ morphogenesis GO:0090596 242 0.503
Mouse
kidney epithelium development GO:0072073 121 0.502
epithelial cell development GO:0002064 159 0.497
Mouse
regulation of voltage gated calcium channel activity GO:1901385 4 0.495
Mouse
prostate gland epithelium morphogenesis GO:0060740 31 0.495
metanephros development GO:0001656 79 0.493
regulation of high voltage gated calcium channel activity GO:1901841 2 0.492
epithelial cell maturation involved in prostate gland development GO:0060743 4 0.491
embryonic digit morphogenesis GO:0042733 56 0.486
detection of glucose GO:0051594 1 0.482
somatic sex determination GO:0018993 2 0.479
glomerulus vasculature development GO:0072012 14 0.477
regulation of apoptotic process involved in outflow tract morphogenesis GO:1902256 2 0.477
positive regulation of cell cycle GO:0045787 92 0.475
epithelial tube formation GO:0072175 130 0.474
regulation of peptide hormone secretion GO:0090276 75 0.470
cellular ketone metabolic process GO:0042180 84 0.462
negative regulation of apoptotic process involved in outflow tract morphogenesis GO:1902257 2 0.459
prostate gland stromal morphogenesis GO:0060741 2 0.458
glomerular mesangial cell development GO:0072144 3 0.457
morphogenesis of embryonic epithelium GO:0016331 159 0.457
mesenchymal cell differentiation GO:0048762 107 0.456
Human
chondrocyte differentiation GO:0002062 72 0.455
Mouse
hair cycle GO:0042633 90 0.455
establishment of neuroblast polarity GO:0045200 1 0.453
developmental maturation GO:0021700 193 0.452
prostate gland development GO:0030850 48 0.448
inner ear morphogenesis GO:0042472 101 0.447
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.443
Human
renal system vasculature development GO:0061437 15 0.442
regulation of positive chemotaxis GO:0050926 7 0.438
regulation of heart growth GO:0060420 31 0.438
Mouse
cell differentiation involved in kidney development GO:0061005 33 0.437
submandibular salivary gland formation GO:0060661 1 0.434
mesoderm formation GO:0001707 62 0.434
transcription from rna polymerase iii promoter GO:0006383 3 0.433
lung proximal distal axis specification GO:0061115 1 0.433
cardiocyte differentiation GO:0035051 87 0.431
Mouse
positive regulation of nervous system development GO:0051962 221 0.430
Mouse
positive regulation of fat cell proliferation GO:0070346 1 0.429
prostate glandular acinus development GO:0060525 12 0.427
regulation of smoothened signaling pathway GO:0008589 58 0.425
artery development GO:0060840 53 0.421
hair follicle development GO:0001942 85 0.420
cell fate specification GO:0001708 72 0.419
Mouse
branch elongation involved in salivary gland morphogenesis GO:0060667 2 0.418
mesenchymal cell differentiation involved in lung development GO:0060915 2 0.418
embryonic appendage morphogenesis GO:0035113 126 0.416
positive regulation of epithelial cell proliferation involved in lung morphogenesis GO:0060501 3 0.413
embryonic placenta development GO:0001892 98 0.408
tissue remodeling GO:0048771 102 0.407
positive regulation of high voltage gated calcium channel activity GO:1901843 1 0.406
thyroid hormone generation GO:0006590 7 0.406
apoptotic process involved in development GO:1902742 28 0.402
Mouse
tissue migration GO:0090130 68 0.399
forebrain neuron development GO:0021884 30 0.397
heart growth GO:0060419 45 0.395
Mouse
negative regulation of glucokinase activity GO:0033132 4 0.386
regulation of homeostatic process GO:0032844 182 0.383
cellular modified amino acid metabolic process GO:0006575 63 0.377
regulation of cellular amine metabolic process GO:0033238 20 0.373
metanephric capsule morphogenesis GO:0072265 1 0.373
ossification GO:0001503 216 0.373
insulin secretion involved in cellular response to glucose stimulus GO:0035773 36 0.372
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.370
Human Mouse
microtubule polymerization GO:0046785 12 0.369
regulation of mitotic cell cycle GO:0007346 126 0.368
renal system pattern specification GO:0072048 9 0.364
apoptotic process involved in outflow tract morphogenesis GO:0003275 2 0.363
digestive tract development GO:0048565 190 0.363
Mouse
positive regulation of white fat cell proliferation GO:0070352 1 0.361
cellular component assembly involved in morphogenesis GO:0010927 139 0.360
Mouse
apoptotic process involved in morphogenesis GO:0060561 25 0.360
Mouse
regulation of angiogenesis GO:0045765 81 0.359
nitrogen compound transport GO:0071705 271 0.359
detection of stimulus GO:0051606 84 0.358
muscle cell differentiation GO:0042692 261 0.358
Mouse
wnt signaling pathway GO:0016055 188 0.356
Mouse
positive regulation of cell adhesion GO:0045785 80 0.352
regulation of cell motility GO:2000145 236 0.348
Human
lung secretory cell differentiation GO:0061140 13 0.348
establishment or maintenance of neuroblast polarity GO:0045196 1 0.348
ear development GO:0043583 200 0.346
Mouse
extracellular structure organization GO:0043062 148 0.346
development of primary female sexual characteristics GO:0046545 73 0.344
Rat
diencephalon development GO:0021536 63 0.344
regulation of endothelial cell migration GO:0010594 22 0.343
nephric duct formation GO:0072179 4 0.343
pattern specification involved in metanephros development GO:0072268 4 0.341
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 40 0.341
striated muscle cell proliferation GO:0014855 39 0.339
Mouse
camera type eye development GO:0043010 266 0.334
mammary gland bud formation GO:0060615 2 0.334
negative regulation of transcription by glucose GO:0045014 1 0.331
epithelial mesenchymal cell signaling GO:0060684 7 0.331
regulation of white fat cell proliferation GO:0070350 2 0.329
metanephros morphogenesis GO:0003338 24 0.324
female somatic sex determination GO:0019101 1 0.324
response to fibroblast growth factor GO:0071774 47 0.324
negative regulation of molecular function GO:0044092 258 0.323
negative regulation of cell development GO:0010721 169 0.323
Human Mouse
cartilage development GO:0051216 140 0.323
Mouse
metanephric nephron development GO:0072210 34 0.322
endocrine pancreas development GO:0031018 29 0.321
Mouse
mammary gland epithelial cell differentiation GO:0060644 13 0.316
male sex differentiation GO:0046661 109 0.315
positive regulation of neuroblast proliferation GO:0002052 19 0.313
embryonic limb morphogenesis GO:0030326 126 0.312
chromatin organization GO:0006325 206 0.312
hindbrain development GO:0030902 128 0.311
regulation of cardiac muscle cell proliferation GO:0060043 23 0.309
Mouse
female sex determination GO:0030237 1 0.306
female genitalia morphogenesis GO:0048807 3 0.306
limb morphogenesis GO:0035108 149 0.304
muscle cell fate commitment GO:0042693 11 0.302
Mouse
epidermis morphogenesis GO:0048730 33 0.302
regulation of wnt signaling pathway GO:0030111 123 0.298
Mouse
mesenchymal epithelial cell signaling involved in lung development GO:0060496 1 0.296
blood circulation GO:0008015 195 0.295
Mouse Rat
regulation of vasculature development GO:1901342 88 0.295
planar cell polarity pathway involved in pericardium morphogenesis GO:0061354 2 0.295
multicellular organism growth GO:0035264 161 0.292
positive regulation of response to wounding GO:1903036 66 0.291
neuron death GO:0070997 154 0.291
primitive streak formation GO:0090009 10 0.290
regulation of embryonic development GO:0045995 71 0.290
positive regulation of cell migration GO:0030335 109 0.289
male anatomical structure morphogenesis GO:0090598 4 0.288
neuron apoptotic process GO:0051402 142 0.288
mesangial cell development GO:0072143 4 0.287
development of primary male sexual characteristics GO:0046546 88 0.285
regulation of gastrulation GO:0010470 16 0.284
smoothened signaling pathway GO:0007224 105 0.284
Mouse
hard palate development GO:0060022 5 0.283
male genitalia morphogenesis GO:0048808 4 0.282
paraxial mesoderm development GO:0048339 18 0.280
male gamete generation GO:0048232 285 0.280
neuroblast proliferation GO:0007405 49 0.272
ventricular cardiac muscle tissue development GO:0003229 38 0.271
Mouse
heart morphogenesis GO:0003007 178 0.270
Mouse
regulation of cellular response to growth factor stimulus GO:0090287 82 0.269
Human
ovulation cycle GO:0042698 59 0.268
planar cell polarity pathway involved in cardiac muscle tissue morphogenesis GO:0061350 2 0.264
negative regulation of hexokinase activity GO:1903300 4 0.263
positive regulation of angiogenesis GO:0045766 46 0.260
muscle tissue morphogenesis GO:0060415 53 0.260
Mouse
negative regulation of neuron death GO:1901215 98 0.259
renal capsule morphogenesis GO:0072128 1 0.259
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.257
Human
regulation of cell adhesion GO:0030155 154 0.257
positive regulation of programmed cell death GO:0043068 218 0.256
asymmetric stem cell division GO:0098722 3 0.255
limbic system development GO:0021761 72 0.255
regulation of canonical wnt signaling pathway GO:0060828 82 0.254
Mouse
cell differentiation in hindbrain GO:0021533 24 0.253
blastocyst development GO:0001824 80 0.253
renal system development GO:0072001 225 0.248
embryonic eye morphogenesis GO:0048048 29 0.248
dopaminergic neuron differentiation GO:0071542 14 0.246
regulation of cardiac muscle tissue development GO:0055024 31 0.245
Mouse
cardiac muscle tissue development GO:0048738 130 0.244
Mouse
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.243
specification of organ identity GO:0010092 30 0.241
metanephric capsule formation GO:0072266 1 0.236
regulation of epithelial cell migration GO:0010632 35 0.236
regulation of muscle tissue development GO:1901861 97 0.235
Mouse
regulation of cell migration GO:0030334 219 0.234
Human
regulation of neuron apoptotic process GO:0043523 122 0.233
paraxial mesoderm formation GO:0048341 6 0.232
organ induction GO:0001759 21 0.231
cell maturation GO:0048469 127 0.231
axonogenesis GO:0007409 274 0.230
negative regulation of neuron differentiation GO:0045665 101 0.229
Mouse
regulation of cellular ketone metabolic process GO:0010565 66 0.229
bronchiole morphogenesis GO:0060436 1 0.228
hypophysis morphogenesis GO:0048850 3 0.227
nuclear transport GO:0051169 139 0.227
positive regulation of ion transmembrane transporter activity GO:0032414 15 0.226
Mouse
retina morphogenesis in camera type eye GO:0060042 45 0.226
hormone metabolic process GO:0042445 86 0.225
rhythmic process GO:0048511 174 0.224
forebrain regionalization GO:0021871 25 0.222
fibroblast growth factor receptor signaling pathway GO:0008543 46 0.220
regulation of kidney development GO:0090183 40 0.219
pattern specification involved in kidney development GO:0061004 8 0.218
spermatogenesis GO:0007283 284 0.218
female gonad development GO:0008585 71 0.218
oligodendrocyte differentiation GO:0048709 53 0.217
neuron fate determination GO:0048664 9 0.217
Mouse
ectoderm formation GO:0001705 3 0.216
skeletal muscle organ development GO:0060538 163 0.216
glomerular endothelium development GO:0072011 2 0.215
olfactory bulb development GO:0021772 30 0.213
mesodermal cell fate commitment GO:0001710 17 0.208
positive regulation of kidney development GO:0090184 28 0.207
kidney mesenchyme development GO:0072074 14 0.205
corticotropin hormone secreting cell differentiation GO:0060128 3 0.204
apoptotic process involved in heart morphogenesis GO:0003278 5 0.204
Mouse
positive regulation of oligodendrocyte differentiation GO:0048714 9 0.203
Mouse
somite rostral caudal axis specification GO:0032525 13 0.201
thyroid hormone metabolic process GO:0042403 16 0.201
vascular wound healing GO:0061042 3 0.200
nephrogenic mesenchyme development GO:0072076 3 0.200
protein localization to nucleus GO:0034504 121 0.200
metanephric capsule specification GO:0072267 1 0.199
somitogenesis GO:0001756 69 0.198
asymmetric neuroblast division GO:0055059 1 0.194
response to growth factor GO:0070848 198 0.194
Human
endothelium development GO:0003158 45 0.193
neuromuscular process GO:0050905 99 0.193
cell cell signaling involved in lung development GO:0060495 1 0.191
regulation of apoptotic process involved in morphogenesis GO:1902337 10 0.191
amine metabolic process GO:0009308 45 0.190
renal capsule specification GO:0072130 1 0.188
regulation of insulin secretion involved in cellular response to glucose stimulus GO:0061178 31 0.188
neural crest cell development GO:0014032 48 0.188
neural tube formation GO:0001841 108 0.188
tube closure GO:0060606 91 0.188
inner ear receptor cell differentiation GO:0060113 61 0.188
actin cytoskeleton organization GO:0030036 220 0.187
Mouse
aminoglycan metabolic process GO:0006022 34 0.186
embryonic epithelial tube formation GO:0001838 130 0.186
cellular response to glucose stimulus GO:0071333 45 0.186
peptide secretion GO:0002790 114 0.184
positive regulation of cell motility GO:2000147 116 0.184
outflow tract morphogenesis GO:0003151 53 0.183
Mouse
regulation of heart morphogenesis GO:2000826 22 0.183
renal vesicle induction GO:0072034 3 0.182
cochlea morphogenesis GO:0090103 22 0.182
positive regulation of activin receptor signaling pathway GO:0032927 3 0.182
regulation of cell size GO:0008361 72 0.182
development of primary sexual characteristics GO:0045137 143 0.182
regulation of transcription from rna polymerase ii promoter by glucose GO:0000430 3 0.181
regulation of cell fate specification GO:0042659 10 0.180
kidney rudiment formation GO:0072003 3 0.179
cell proliferation in hindbrain GO:0021534 10 0.179
regulation of cartilage development GO:0061035 44 0.179
Mouse
harderian gland development GO:0070384 2 0.178
carbon catabolite repression of transcription GO:0045013 1 0.177
negative regulation of transcription from rna polymerase ii promoter by glucose GO:0000433 1 0.175
regulation of thyroid hormone generation GO:2000609 4 0.175
positive regulation of epithelial cell migration GO:0010634 19 0.175
pyramidal neuron development GO:0021860 8 0.171
regulation of organelle organization GO:0033043 289 0.171
organic hydroxy compound metabolic process GO:1901615 203 0.170
regulation of osteoblast differentiation GO:0045667 67 0.170
dichotomous subdivision of terminal units involved in ureteric bud branching GO:0060678 1 0.170
negative regulation of nervous system development GO:0051961 156 0.170
Mouse
embryonic genitalia morphogenesis GO:0030538 4 0.169
adult locomotory behavior GO:0008344 91 0.168
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 61 0.167
odontogenesis of dentin containing tooth GO:0042475 66 0.167
Mouse
cerebral cortex development GO:0021987 86 0.166
cardiac ventricle development GO:0003231 83 0.165
Mouse
trachea cartilage morphogenesis GO:0060535 4 0.163
neural crest cell differentiation GO:0014033 54 0.162
positive regulation of apoptotic process GO:0043065 217 0.160
regulation of blood vessel endothelial cell migration GO:0043535 12 0.159
positive regulation of endothelial cell migration GO:0010595 12 0.158
positive regulation of mesenchymal cell proliferation GO:0002053 33 0.157
bone development GO:0060348 120 0.156
epithelial cell differentiation involved in kidney development GO:0035850 23 0.156
cellular carbohydrate metabolic process GO:0044262 119 0.154
regulation of apoptotic signaling pathway GO:2001233 197 0.154
dichotomous subdivision of an epithelial terminal unit GO:0060600 11 0.153
regulation of cytoplasmic transport GO:1903649 112 0.153
axis elongation involved in somitogenesis GO:0090245 4 0.152
negative regulation of mesenchymal cell apoptotic process involved in metanephros development GO:1900212 4 0.152
fibroblast growth factor receptor signaling pathway involved in mammary gland specification GO:0060595 2 0.151
regulation of detection of glucose GO:2000970 1 0.150
canonical wnt signaling pathway GO:0060070 130 0.150
Mouse
metanephric nephron morphogenesis GO:0072273 19 0.149
type ii pneumocyte differentiation GO:0060510 7 0.149
germ cell development GO:0007281 185 0.149
inorganic ion transmembrane transport GO:0098660 234 0.149
Mouse
cell adhesion GO:0007155 329 0.147
regulation of cellular amino acid metabolic process GO:0006521 5 0.147
pancreatic pp cell fate commitment GO:0003329 2 0.145
Mouse
epithelial cell migration GO:0010631 63 0.145
connective tissue development GO:0061448 179 0.144
Mouse
positive regulation of cellular amine metabolic process GO:0033240 5 0.143
embryonic digestive tract morphogenesis GO:0048557 17 0.142
renal interstitial fibroblast development GO:0072141 5 0.141
regulation of transcription by glucose GO:0046015 3 0.141
mesenchymal cell development GO:0014031 93 0.141
Human
positive regulation of striated muscle tissue development GO:0045844 31 0.140
nuclear import GO:0051170 95 0.140
regulation of secretion GO:0051046 274 0.139
regulation of mesenchymal cell apoptotic process involved in metanephros development GO:1900211 4 0.138
negative regulation of mesodermal cell fate specification GO:0042662 3 0.136
spinal cord development GO:0021510 81 0.135
Mouse
white fat cell proliferation GO:0070343 2 0.135
metanephric mesenchymal cell differentiation GO:0072162 3 0.134
spermatid differentiation GO:0048515 115 0.134
negative regulation of growth GO:0045926 99 0.133
metanephric nephron tubule formation GO:0072289 4 0.133
cell proliferation in external granule layer GO:0021924 10 0.133
neuron recognition GO:0008038 25 0.132
myoblast differentiation involved in skeletal muscle regeneration GO:0014835 3 0.132
regulation of defense response GO:0031347 233 0.131
ectoderm development GO:0007398 15 0.128
negative regulation of cell cycle GO:0045786 123 0.126
glucose homeostasis GO:0042593 128 0.126
regulation of neuroblast proliferation GO:1902692 27 0.125
mammary gland morphogenesis GO:0060443 54 0.124
second messenger mediated signaling GO:0019932 73 0.123
positive regulation of immature t cell proliferation GO:0033091 4 0.122
hypothalamus development GO:0021854 16 0.122
Mouse
regulation of carbohydrate metabolic process GO:0006109 75 0.121
mesodermal cell migration GO:0008078 4 0.121
regulation of hormone secretion GO:0046883 88 0.120
wnt signaling pathway involved in forebrain neuroblast division GO:0021874 2 0.119
positive regulation of wound healing GO:0090303 17 0.119
positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 3 0.119
pyramidal neuron differentiation GO:0021859 9 0.119
renal capsule development GO:0072127 1 0.118
negative regulation of sterol transport GO:0032372 4 0.118
adenohypophysis development GO:0021984 14 0.118
olfactory bulb interneuron differentiation GO:0021889 12 0.117
regulation of cellular component size GO:0032535 121 0.117
regulation of anatomical structure size GO:0090066 178 0.116
regulation of fat cell differentiation GO:0045598 81 0.116
cytokine production GO:0001816 319 0.116
regulation of neuron death GO:1901214 134 0.116
neuroepithelial cell differentiation GO:0060563 37 0.116
somatic stem cell maintenance GO:0035019 47 0.116
retinal bipolar neuron differentiation GO:0060040 5 0.115
female genitalia development GO:0030540 14 0.115

Nkx2-1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.304
endocrine system disease DOID:28 0 0.304
thyroid gland disease DOID:50 0 0.270
hypothyroidism DOID:1459 0 0.270