Mus musculus

182 known processes

Nkx2-2

NK2 transcription factor related, locus 2 (Drosophila)

(Aliases: Nkx-2.2,tinman,Nkx2.2)

Nkx2-2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
axonogenesis GO:0007409 274 0.976
Zebrafish Mouse
spinal cord development GO:0021510 81 0.975
central nervous system neuron differentiation GO:0021953 162 0.956
glial cell differentiation GO:0010001 131 0.950
spinal cord motor neuron cell fate specification GO:0021520 13 0.934
cell fate commitment GO:0045165 210 0.931
neuron fate specification GO:0048665 30 0.916
action potential GO:0001508 78 0.910
oligodendrocyte development GO:0014003 20 0.903
cell differentiation in spinal cord GO:0021515 53 0.895
smoothened signaling pathway GO:0007224 105 0.885
gliogenesis GO:0042063 141 0.876
central nervous system neuron development GO:0021954 67 0.872
neuron migration GO:0001764 122 0.866
Mouse
oligodendrocyte differentiation GO:0048709 53 0.856
glial cell development GO:0021782 54 0.854
ensheathment of neurons GO:0007272 76 0.852
myelination GO:0042552 74 0.831
forebrain development GO:0030900 302 0.819
Mouse
transmission of nerve impulse GO:0019226 76 0.817
type b pancreatic cell differentiation GO:0003309 13 0.806
regionalization GO:0003002 337 0.802
connective tissue development GO:0061448 179 0.780
Mouse
skeletal system development GO:0001501 356 0.778
Mouse
diencephalon development GO:0021536 63 0.775
Mouse
pituitary gland development GO:0021983 38 0.773
Mouse
ventral spinal cord development GO:0021517 48 0.771
negative regulation of cell development GO:0010721 169 0.759
camera type eye development GO:0043010 266 0.756
spinal cord motor neuron differentiation GO:0021522 35 0.745
forebrain generation of neurons GO:0021872 63 0.738
Mouse
axon ensheathment GO:0008366 76 0.737
endocrine system development GO:0035270 98 0.728
cell fate determination GO:0001709 32 0.722
neuronal action potential GO:0019228 54 0.695
motor neuron migration GO:0097475 4 0.680
cerebral cortex development GO:0021987 86 0.677
Mouse
ventral spinal cord interneuron fate commitment GO:0060579 14 0.676
regulation of gliogenesis GO:0014013 50 0.674
stem cell development GO:0048864 219 0.660
transdifferentiation GO:0060290 1 0.652
ventral spinal cord interneuron specification GO:0021521 11 0.647
neuroepithelial cell differentiation GO:0060563 37 0.627
enteroendocrine cell differentiation GO:0035883 16 0.627
regulation of neural precursor cell proliferation GO:2000177 70 0.625
cell fate specification GO:0001708 72 0.612
extracellular matrix organization GO:0030198 147 0.604
negative regulation of neuron differentiation GO:0045665 101 0.598
columnar cuboidal epithelial cell differentiation GO:0002065 82 0.581
negative regulation of glial cell differentiation GO:0045686 21 0.577
kidney epithelium development GO:0072073 121 0.560
neural precursor cell proliferation GO:0061351 121 0.559
spinal cord patterning GO:0021511 25 0.557
cellular amino acid metabolic process GO:0006520 103 0.553
multicellular organismal signaling GO:0035637 91 0.548
epidermis development GO:0008544 187 0.533
regulation of secretion by cell GO:1903530 249 0.532
pancreatic pp cell differentiation GO:0003312 2 0.511
cell fate specification involved in pattern specification GO:0060573 11 0.497
cardiac chamber morphogenesis GO:0003206 93 0.492
Mouse
positive regulation of secretion by cell GO:1903532 114 0.488
chondrocyte differentiation GO:0002062 72 0.485
Mouse
axon guidance GO:0007411 141 0.468
Zebrafish Mouse
positive regulation of peptide secretion GO:0002793 33 0.465
negative regulation of nervous system development GO:0051961 156 0.452
pancreas development GO:0031016 57 0.449
regulation of neuron differentiation GO:0045664 281 0.445
ureteric bud development GO:0001657 94 0.441
mesonephric tubule development GO:0072164 94 0.434
hippocampus development GO:0021766 52 0.434
Mouse
limb morphogenesis GO:0035108 149 0.426
epithelial cell development GO:0002064 159 0.426
auditory receptor cell fate determination GO:0042668 3 0.425
hindbrain development GO:0030902 128 0.425
peripheral nervous system neuron axonogenesis GO:0048936 3 0.424
endocrine pancreas development GO:0031018 29 0.415
positive regulation of peptide hormone secretion GO:0090277 31 0.414
chemotaxis GO:0006935 247 0.414
Zebrafish Mouse
nitrogen compound transport GO:0071705 271 0.413
regulation of neuroblast proliferation GO:1902692 27 0.408
central nervous system projection neuron axonogenesis GO:0021952 21 0.404
developmental growth involved in morphogenesis GO:0060560 138 0.393
positive regulation of neuroblast proliferation GO:0002052 19 0.387
mesenchymal cell differentiation GO:0048762 107 0.385
regulation of neuron apoptotic process GO:0043523 122 0.381
regulation of ossification GO:0030278 112 0.373
regulation of membrane potential GO:0042391 192 0.369
determination of left right symmetry GO:0007368 80 0.368
Mouse
central nervous system neuron axonogenesis GO:0021955 28 0.366
glandular epithelial cell differentiation GO:0002067 38 0.360
neuron projection extension GO:1990138 64 0.350
positive regulation of insulin secretion GO:0032024 26 0.350
cell type specific apoptotic process GO:0097285 268 0.348
Mouse
regulation of peptide secretion GO:0002791 77 0.345
inner ear morphogenesis GO:0042472 101 0.344
positive regulation of secretion GO:0051047 130 0.344
limbic system development GO:0021761 72 0.341
Mouse
negative regulation of cell proliferation GO:0008285 296 0.340
Mouse
cerebellum development GO:0021549 77 0.340
organic hydroxy compound metabolic process GO:1901615 203 0.339
spinal cord motor neuron migration GO:0097476 4 0.333
sensory organ morphogenesis GO:0090596 242 0.327
Mouse
multi organism behavior GO:0051705 62 0.326
limb development GO:0060173 166 0.323
positive regulation of cell development GO:0010720 237 0.323
regulation of stem cell proliferation GO:0072091 78 0.322
telencephalon development GO:0021537 186 0.320
Mouse
negative regulation of gliogenesis GO:0014014 23 0.313
regulation of axon diameter GO:0031133 6 0.304
embryonic epithelial tube formation GO:0001838 130 0.300
regulation of glial cell differentiation GO:0045685 41 0.299
cell adhesion GO:0007155 329 0.299
astrocyte differentiation GO:0048708 43 0.297
forebrain neuron development GO:0021884 30 0.295
cell proliferation in hindbrain GO:0021534 10 0.288
central nervous system myelination GO:0022010 12 0.286
cerebral cortex neuron differentiation GO:0021895 19 0.280
Mouse
ventral spinal cord interneuron differentiation GO:0021514 16 0.276
columnar cuboidal epithelial cell development GO:0002066 29 0.273
amide transport GO:0042886 138 0.273
spermatogenesis GO:0007283 284 0.269
regulation of secretion GO:0051046 274 0.269
somitogenesis GO:0001756 69 0.269
monosaccharide metabolic process GO:0005996 106 0.268
cerebral cortex gabaergic interneuron migration GO:0021853 6 0.268
positive regulation of auditory receptor cell differentiation GO:0045609 1 0.265
neuroendocrine cell differentiation GO:0061101 7 0.263
cellular response to monosaccharide stimulus GO:0071326 47 0.262
ureteric bud morphogenesis GO:0060675 62 0.259
insulin secretion GO:0030073 89 0.258
digestive tract morphogenesis GO:0048546 147 0.254
Mouse
forebrain neuron differentiation GO:0021879 52 0.253
Mouse
regulation of peptide transport GO:0090087 91 0.245
regulation of transcription from rna polymerase ii promoter involved in ventral spinal cord interneuron specification GO:0021913 4 0.238
regulation of neuron death GO:1901214 134 0.237
cellular response to glucose stimulus GO:0071333 45 0.236
male gamete generation GO:0048232 285 0.235
regulation of hormone levels GO:0010817 211 0.235
formation of primary germ layer GO:0001704 77 0.231
positive regulation of neural precursor cell proliferation GO:2000179 42 0.228
tongue development GO:0043586 18 0.225
Mouse
digestive tract development GO:0048565 190 0.225
developmental cell growth GO:0048588 84 0.225
mesenchymal cell development GO:0014031 93 0.224
nephron tubule development GO:0072080 84 0.222
positive regulation of nervous system development GO:0051962 221 0.221
peptide transport GO:0015833 133 0.219
positive regulation of gliogenesis GO:0014015 27 0.219
carbon catabolite activation of transcription from rna polymerase ii promoter GO:0000436 4 0.218
neuroblast proliferation GO:0007405 49 0.217
blood circulation GO:0008015 195 0.217
Mouse
cell proliferation in forebrain GO:0021846 30 0.216
cell differentiation involved in kidney development GO:0061005 33 0.215
cardiac neural crest cell migration involved in outflow tract morphogenesis GO:0003253 3 0.215
paraxial mesodermal cell fate commitment GO:0048343 2 0.211
neuron projection guidance GO:0097485 141 0.211
Zebrafish Mouse
pancreatic a cell differentiation GO:0003310 7 0.208
regulation of hormone secretion GO:0046883 88 0.208
astrocyte fate commitment GO:0060018 4 0.205
developmental maturation GO:0021700 193 0.205
protein localization to nucleus GO:0034504 121 0.205
muscle cell differentiation GO:0042692 261 0.204
Mouse
positive regulation of neuron differentiation GO:0045666 141 0.201
pallium development GO:0021543 120 0.201
Mouse
catecholamine biosynthetic process GO:0042423 11 0.199
heart morphogenesis GO:0003007 178 0.199
Mouse
regulation of smoothened signaling pathway GO:0008589 58 0.199
spinal cord oligodendrocyte cell fate specification GO:0021530 3 0.197
peptide secretion GO:0002790 114 0.197
regulation of cell cycle GO:0051726 281 0.193
embryonic placenta development GO:0001892 98 0.193
embryonic limb morphogenesis GO:0030326 126 0.192
stem cell proliferation GO:0072089 117 0.191
bone mineralization GO:0030282 54 0.190
neuromuscular process controlling balance GO:0050885 59 0.189
mesenchyme development GO:0060485 152 0.188
Mouse
regulation of neuron migration GO:2001222 22 0.187
stem cell differentiation GO:0048863 268 0.186
Mouse
morphogenesis of embryonic epithelium GO:0016331 159 0.184
organonitrogen compound biosynthetic process GO:1901566 192 0.183
negative regulation of type b pancreatic cell apoptotic process GO:2000675 3 0.180
lateral motor column neuron migration GO:0097477 3 0.179
regulation of epithelial cell proliferation GO:0050678 141 0.179
Mouse
neural crest cell differentiation GO:0014033 54 0.178
regulation of cartilage development GO:0061035 44 0.178
Mouse
somatotropin secreting cell differentiation GO:0060126 4 0.177
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.177
positive regulation of stem cell proliferation GO:2000648 59 0.176
regulation of organ morphogenesis GO:2000027 144 0.176
regulation of cell migration GO:0030334 219 0.175
urogenital system development GO:0001655 261 0.175
leukocyte differentiation GO:0002521 342 0.174
Mouse
cell maturation GO:0048469 127 0.174
neuron apoptotic process GO:0051402 142 0.172
neuroblast differentiation GO:0014016 2 0.172
peptide hormone secretion GO:0030072 109 0.170
regulation of bone mineralization GO:0030500 31 0.169
cardiac ventricle development GO:0003231 83 0.169
Mouse
ear development GO:0043583 200 0.168
Mouse
regulation of auditory receptor cell differentiation GO:0045607 4 0.166
regulation of cell motility GO:2000145 236 0.166
mitral valve development GO:0003174 4 0.165
glucose homeostasis GO:0042593 128 0.162
carbohydrate homeostasis GO:0033500 128 0.161
positive regulation of cellular amine metabolic process GO:0033240 5 0.160
positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation GO:2000802 1 0.160
regulation of neuron projection development GO:0010975 169 0.160
cerebellum morphogenesis GO:0021587 42 0.158
mitotic cell cycle GO:0000278 195 0.158
skin development GO:0043588 220 0.158
cell differentiation involved in embryonic placenta development GO:0060706 26 0.157
cochlea morphogenesis GO:0090103 22 0.157
response to organonitrogen compound GO:0010243 246 0.157
embryonic appendage morphogenesis GO:0035113 126 0.156
appendage development GO:0048736 166 0.156
carbon catabolite repression of transcription from rna polymerase ii promoter GO:0000437 1 0.154
fat cell differentiation GO:0045444 160 0.153
hormone secretion GO:0046879 128 0.153
cerebral cortex gabaergic interneuron differentiation GO:0021892 9 0.152
Mouse
digestive system development GO:0055123 200 0.147
positive regulation of transcription from rna polymerase ii promoter involved in norepinephrine biosynthetic process GO:2000763 1 0.147
regulation of peptide hormone secretion GO:0090276 75 0.145
regulation of transcription involved in cell fate commitment GO:0060850 15 0.144
retina morphogenesis in camera type eye GO:0060042 45 0.142
substrate independent telencephalic tangential migration GO:0021826 8 0.142
renal system development GO:0072001 225 0.142
metanephros development GO:0001656 79 0.142
response to alkaloid GO:0043279 34 0.142
paraxial mesodermal cell differentiation GO:0048342 2 0.142
cell proliferation in external granule layer GO:0021924 10 0.141
myeloid cell differentiation GO:0030099 233 0.141
Mouse
positive regulation of inner ear receptor cell differentiation GO:2000982 1 0.140
cerebral cortex gabaergic interneuron development GO:0021894 6 0.140
neural crest cell development GO:0014032 48 0.140
synaptic transmission gabaergic GO:0051932 19 0.139
regulation of response to wounding GO:1903034 189 0.139
inorganic ion transmembrane transport GO:0098660 234 0.136
Mouse
cellular carbohydrate metabolic process GO:0044262 119 0.134
cell growth GO:0016049 130 0.133
nephron morphogenesis GO:0072028 69 0.133
dopaminergic neuron differentiation GO:0071542 14 0.133
response to drug GO:0042493 75 0.130
auditory receptor cell fate specification GO:0042667 1 0.128
regulation of body fluid levels GO:0050878 162 0.128
sensory perception of mechanical stimulus GO:0050954 107 0.126
molting cycle GO:0042303 90 0.126
respiratory system development GO:0060541 190 0.126
Mouse
kidney morphogenesis GO:0060993 83 0.125
myotube differentiation GO:0014902 105 0.125
ameboidal type cell migration GO:0001667 128 0.125
neuromuscular process GO:0050905 99 0.124
regulation of cellular component size GO:0032535 121 0.124
cerebellar granule cell precursor proliferation GO:0021930 10 0.123
tendon cell differentiation GO:0035990 4 0.123
lung epithelial cell differentiation GO:0060487 29 0.123
Mouse
stem cell maintenance GO:0019827 130 0.122
embryonic skeletal system development GO:0048706 120 0.122
Mouse
somatotropin secreting cell development GO:0060133 2 0.121
metanephric loop of henle development GO:0072236 4 0.121
histone modification GO:0016570 159 0.120
small gtpase mediated signal transduction GO:0007264 97 0.119
regulation of cellular amine metabolic process GO:0033238 20 0.119
kidney development GO:0001822 213 0.119
mesonephros development GO:0001823 97 0.118
hair follicle development GO:0001942 85 0.118
hexose metabolic process GO:0019318 98 0.118
sensory perception GO:0007600 245 0.118
regulation of system process GO:0044057 200 0.117
Mouse
bmp signaling pathway GO:0030509 93 0.117
Mouse
peptidyl amino acid modification GO:0018193 336 0.116
cellular response to peptide GO:1901653 92 0.116
forebrain regionalization GO:0021871 25 0.114
Mouse
regulation of osteoblast differentiation GO:0045667 67 0.114
myelination in peripheral nervous system GO:0022011 19 0.113
positive regulation of cell migration GO:0030335 109 0.113
protein import into nucleus GO:0006606 95 0.112
lymphocyte differentiation GO:0030098 242 0.111
Mouse
regulation of cellular carbohydrate metabolic process GO:0010675 75 0.111
cell fate commitment involved in pattern specification GO:0060581 14 0.110
gabaergic neuron differentiation GO:0097154 11 0.109
Mouse
odontogenesis of dentin containing tooth GO:0042475 66 0.108
Mouse
catecholamine metabolic process GO:0006584 30 0.106
myoblast differentiation GO:0045445 52 0.106
epithelial cell proliferation GO:0050673 174 0.106
Mouse
type b pancreatic cell development GO:0003323 10 0.106
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 40 0.105
leukocyte homeostasis GO:0001776 79 0.105
Mouse
negative regulation of molecular function GO:0044092 258 0.105
regulation of axon extension GO:0030516 43 0.104
cell differentiation in hindbrain GO:0021533 24 0.103
extracellular structure organization GO:0043062 148 0.103
phenol containing compound metabolic process GO:0018958 60 0.102
regulation of anatomical structure size GO:0090066 178 0.102
apoptotic signaling pathway GO:0097190 306 0.102
embryonic organ morphogenesis GO:0048562 276 0.101
Mouse
neural tube development GO:0021915 160 0.100
Zebrafish
autonomic nervous system development GO:0048483 43 0.099
stem cell fate specification GO:0048866 3 0.099
positive regulation of protein modification process GO:0031401 299 0.097
developmental programmed cell death GO:0010623 41 0.097
Mouse
development of primary sexual characteristics GO:0045137 143 0.096
Mouse
metanephric dct cell differentiation GO:0072240 3 0.096
thyroid stimulating hormone secreting cell differentiation GO:0060129 4 0.095
septum primum development GO:0003284 4 0.095
cerebral cortex radial glia guided migration GO:0021801 17 0.094
renal tubule development GO:0061326 87 0.094
positive regulation of protein phosphorylation GO:0001934 242 0.094
regulation of bmp signaling pathway GO:0030510 60 0.094
regulation of endocardial cushion to mesenchymal transition involved in heart valve formation GO:2000800 1 0.094
ossification GO:0001503 216 0.093
corpus callosum morphogenesis GO:0021540 3 0.093
metanephric nephron tubule development GO:0072234 16 0.093
ventral midline development GO:0007418 4 0.092
Zebrafish
positive regulation of mechanoreceptor differentiation GO:0045633 1 0.091
biomineral tissue development GO:0031214 64 0.090
embryonic heart tube development GO:0035050 65 0.090
Mouse
regulation of insulin secretion involved in cellular response to glucose stimulus GO:0061178 31 0.089
glucose metabolic process GO:0006006 92 0.088
ras protein signal transduction GO:0007265 77 0.088
regulation of chondrocyte differentiation GO:0032330 33 0.088
Mouse
anion transport GO:0006820 177 0.088
interneuron migration from the subpallium to the cortex GO:0021830 7 0.087
cartilage development GO:0051216 140 0.086
Mouse
cochlea development GO:0090102 35 0.086
cellular response to cytokine stimulus GO:0071345 189 0.086
nephron tubule morphogenesis GO:0072078 68 0.085
regulation of muscle contraction GO:0006937 49 0.085
Mouse
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.084
satellite cell activation involved in skeletal muscle regeneration GO:0014901 3 0.084
pyramidal neuron migration GO:0021852 1 0.084
regulation of blood circulation GO:1903522 93 0.083
Mouse
chromatin modification GO:0016568 187 0.083
inner ear receptor cell differentiation GO:0060113 61 0.083
negative regulation of phosphate metabolic process GO:0045936 184 0.083
spinal cord oligodendrocyte cell differentiation GO:0021529 3 0.082
skeletal muscle organ development GO:0060538 163 0.081
noradrenergic neuron differentiation GO:0003357 6 0.081
neural retina development GO:0003407 41 0.080
hemangioblast cell differentiation GO:0060217 1 0.080
cellular response to growth factor stimulus GO:0071363 197 0.079
subpallium development GO:0021544 20 0.079
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.079
horizontal cell localization GO:0035852 1 0.078
multicellular organismal reproductive behavior GO:0033057 23 0.078
male sex determination GO:0030238 14 0.078
skeletal system morphogenesis GO:0048705 203 0.078
Mouse
cardiocyte differentiation GO:0035051 87 0.078
Mouse
visceral motor neuron differentiation GO:0021524 3 0.078
amine metabolic process GO:0009308 45 0.077
carbohydrate metabolic process GO:0005975 230 0.077
forebrain neuron fate commitment GO:0021877 13 0.077
Mouse
positive regulation of glial cell differentiation GO:0045687 21 0.077
determination of heart left right asymmetry GO:0061371 48 0.076
Mouse
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger GO:0007187 55 0.076
astrocyte development GO:0014002 12 0.075
photoreceptor cell differentiation GO:0046530 52 0.074
positive regulation of skeletal muscle tissue regeneration GO:0043415 4 0.074
cation transport GO:0006812 399 0.074
Mouse
lung morphogenesis GO:0060425 50 0.073
skeletal muscle cell differentiation GO:0035914 66 0.073
cellular response to organonitrogen compound GO:0071417 145 0.073
cardiac septum morphogenesis GO:0060411 46 0.073
g protein coupled receptor signaling pathway GO:0007186 243 0.073
gland development GO:0048732 330 0.072
Mouse
ectoderm formation GO:0001705 3 0.072
gonad development GO:0008406 141 0.072
Mouse
metencephalon development GO:0022037 89 0.072
mesodermal cell differentiation GO:0048333 22 0.071
hair cell differentiation GO:0035315 40 0.071
chondrocyte development GO:0002063 24 0.071
neuron death GO:0070997 154 0.071
bone development GO:0060348 120 0.071
olfactory bulb development GO:0021772 30 0.070
retina development in camera type eye GO:0060041 119 0.070
nephron epithelium development GO:0072009 92 0.069
nuclear transport GO:0051169 139 0.069
corpus callosum development GO:0022038 10 0.069
muscle contraction GO:0006936 101 0.069
Mouse
epithelial tube formation GO:0072175 130 0.069
eye photoreceptor cell differentiation GO:0001754 41 0.069
dentate gyrus development GO:0021542 14 0.068
neuroblast fate commitment GO:0014017 1 0.067
positive regulation of osteoblast differentiation GO:0045669 34 0.067
cellular amine metabolic process GO:0044106 44 0.067
regulation of synaptic plasticity GO:0048167 87 0.067
regulation of cell activation GO:0050865 289 0.066
peptidyl tyrosine modification GO:0018212 145 0.066
epithelial to mesenchymal transition GO:0001837 47 0.066
regulation of glucose metabolic process GO:0010906 60 0.066
membrane depolarization GO:0051899 64 0.066
muscle tissue development GO:0060537 308 0.066
Mouse
negative regulation of cell cycle GO:0045786 123 0.065
syncytium formation by plasma membrane fusion GO:0000768 42 0.064
protein maturation GO:0051604 176 0.064
regulation of cyclic nucleotide metabolic process GO:0030799 40 0.064
neuron maturation GO:0042551 29 0.064
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.064
regulation of protein transport GO:0051223 163 0.063
germ line sex determination GO:0018992 3 0.063
regulation of angiogenesis GO:0045765 81 0.063
prostate gland development GO:0030850 48 0.063
circulatory system process GO:0003013 197 0.062
Mouse
regulation of biomineral tissue development GO:0070167 33 0.062
positive regulation of keratinocyte proliferation GO:0010838 4 0.061
regeneration GO:0031099 38 0.061
anterior commissure morphogenesis GO:0021960 6 0.061
renal vesicle induction GO:0072034 3 0.060
semaphorin plexin signaling pathway involved in outflow tract morphogenesis GO:0071527 1 0.060
mechanoreceptor differentiation GO:0042490 67 0.060
determination of left right asymmetry in nervous system GO:0035545 1 0.059
myoblast differentiation involved in skeletal muscle regeneration GO:0014835 3 0.059
negative regulation of glial cell proliferation GO:0060253 4 0.059
sensory perception of light stimulus GO:0050953 54 0.059
regulation of transcription from rna polymerase ii promoter involved in spinal cord motor neuron fate specification GO:0021912 3 0.059
lymphocyte apoptotic process GO:0070227 54 0.059
cellular ketone metabolic process GO:0042180 84 0.059
positive regulation of bmp signaling pathway GO:0030513 23 0.059
carbohydrate transport GO:0008643 62 0.058
t cell activation GO:0042110 289 0.058
Mouse
adenylate cyclase modulating g protein coupled receptor signaling pathway GO:0007188 54 0.058
positive regulation of rna polymerase ii transcriptional preinitiation complex assembly GO:0045899 2 0.057
ion transmembrane transport GO:0034220 361 0.057
Mouse
embryonic skeletal system morphogenesis GO:0048704 91 0.057
mesonephric epithelium development GO:0072163 94 0.057
paramesonephric duct development GO:0061205 3 0.056
auditory receptor cell differentiation GO:0042491 37 0.056
regulation of rna polymerase ii transcriptional preinitiation complex assembly GO:0045898 2 0.056
neural tube formation GO:0001841 108 0.055
retinal bipolar neuron differentiation GO:0060040 5 0.055
positive regulation of hormone secretion GO:0046887 38 0.055
regulation of satellite cell activation involved in skeletal muscle regeneration GO:0014717 3 0.055
sensory perception of sound GO:0007605 97 0.055
protein catabolic process GO:0030163 221 0.055
regulation of transmembrane transport GO:0034762 128 0.055
Mouse
pharyngeal system development GO:0060037 17 0.055
Mouse
tube formation GO:0035148 140 0.055
regulation of cellular ketone metabolic process GO:0010565 66 0.055
mating GO:0007618 27 0.055
tube closure GO:0060606 91 0.054
mitotic cell cycle process GO:1903047 159 0.054
response to pain GO:0048265 26 0.054
stem cell fate commitment GO:0048865 5 0.054
tendon formation GO:0035992 4 0.054
gonad morphogenesis GO:0035262 1 0.054
learning or memory GO:0007611 148 0.054
midbrain hindbrain boundary morphogenesis GO:0021555 4 0.054
renal vesicle morphogenesis GO:0072077 15 0.053
endocardial cushion to mesenchymal transition involved in heart valve formation GO:0003199 4 0.053
associative learning GO:0008306 61 0.053
endocardium formation GO:0060214 4 0.053
apoptotic process involved in morphogenesis GO:0060561 25 0.053
Mouse
regulation of stem cell differentiation GO:2000736 50 0.052
Mouse
nitric oxide mediated signal transduction GO:0007263 4 0.052
spinal cord dorsal ventral patterning GO:0021513 23 0.052
somatic stem cell maintenance GO:0035019 47 0.052
sympathetic nervous system development GO:0048485 22 0.052
inorganic anion transport GO:0015698 43 0.052
establishment or maintenance of cell polarity GO:0007163 86 0.052
positive regulation of epithelial cell proliferation GO:0050679 68 0.052
midgut development GO:0007494 4 0.051
transmembrane transport GO:0055085 412 0.051
Mouse
lung development GO:0030324 164 0.051
Mouse
cellular response to external stimulus GO:0071496 88 0.051
regulation of protein localization GO:0032880 231 0.051
metanephric nephron tubule formation GO:0072289 4 0.050
respiratory tube development GO:0030323 167 0.050
Mouse
negative regulation of neuron death GO:1901215 98 0.049
pancreatic a cell fate commitment GO:0003326 2 0.049
adult locomotory behavior GO:0008344 91 0.049
carbohydrate derivative biosynthetic process GO:1901137 183 0.049
embryonic digestive tract development GO:0048566 27 0.049
positive regulation of epithelial cell migration GO:0010634 19 0.049
multicellular organism growth GO:0035264 161 0.049
positive regulation of epithelial cell differentiation involved in kidney development GO:2000698 2 0.048
noradrenergic neuron development GO:0003358 3 0.048
gall bladder development GO:0061010 2 0.048
ear morphogenesis GO:0042471 118 0.048
Mouse
mesonephric duct formation GO:0072181 2 0.047
wound healing GO:0042060 157 0.047
female sex determination GO:0030237 1 0.047
regulation of cerebellar granule cell precursor proliferation GO:0021936 12 0.047
neural fold elevation formation GO:0021502 1 0.047
regulation of purine nucleotide biosynthetic process GO:1900371 34 0.047
mesoderm development GO:0007498 100 0.047
fear response GO:0042596 33 0.047
positive regulation of cell motility GO:2000147 116 0.047
neural crest cell migration GO:0001755 32 0.046
bone morphogenesis GO:0060349 78 0.046
regulation of neurotransmitter levels GO:0001505 87 0.046
carbon catabolite regulation of transcription from rna polymerase ii promoter GO:0000429 4 0.046
regulation of kinase activity GO:0043549 249 0.046

Nkx2-2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
diabetes mellitus DOID:9351 0 0.083
disease of metabolism DOID:0014667 0 0.083
carbohydrate metabolism disease DOID:0050013 0 0.083
glucose metabolism disease DOID:4194 0 0.083
acquired metabolic disease DOID:0060158 0 0.083
disease of anatomical entity DOID:7 0 0.066
musculoskeletal system disease DOID:17 0 0.066
connective tissue disease DOID:65 0 0.066