Mus musculus

377 known processes

Nkx2-5

NK2 transcription factor related, locus 5 (Drosophila)

(Aliases: tinman,Csx,Nkx-2.5,Nkx2.5)

Nkx2-5 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
positive regulation of cardioblast differentiation GO:0051891 3 1.000
cardioblast migration to the midline involved in heart field formation GO:0060975 1 1.000
regulation of cardiac muscle tissue development GO:0055024 31 1.000
cardiac muscle tissue development GO:0048738 130 1.000
atrial ventricular junction remodeling GO:0003294 2 1.000
endodermal cell fate commitment GO:0001711 12 1.000
sinoatrial node cell differentiation GO:0060921 3 1.000
striated muscle tissue development GO:0014706 293 1.000
cardioblast migration GO:0003260 1 1.000
embryonic organ morphogenesis GO:0048562 276 1.000
heart morphogenesis GO:0003007 178 1.000
regulation of cardiac muscle cell proliferation GO:0060043 23 1.000
endocardial cushion to mesenchymal transition involved in heart valve formation GO:0003199 4 1.000
cardiac conduction system development GO:0003161 12 1.000
regulation of cardioblast differentiation GO:0051890 3 1.000
regulation of cardiac muscle tissue growth GO:0055021 26 1.000
ventricular cardiac muscle cell action potential GO:0086005 4 1.000
positive regulation of cardiac muscle tissue growth GO:0055023 15 1.000
commitment of neuronal cell to specific neuron type in forebrain GO:0021902 7 1.000
mesenchyme development GO:0060485 152 1.000
cardiac muscle cell proliferation GO:0060038 31 1.000
cardiac muscle cell development GO:0055013 39 1.000
tricuspid valve development GO:0003175 3 1.000
cardiac cell fate determination GO:0060913 2 1.000
axon guidance GO:0007411 141 1.000
Mouse
ventricular cardiac muscle cell differentiation GO:0055012 17 1.000
bundle of his development GO:0003166 4 1.000
cell migration to the midline involved in heart development GO:0003318 1 1.000
cardiocyte differentiation GO:0035051 87 1.000
cardiac muscle tissue growth GO:0055017 37 1.000
septum transversum development GO:0003343 2 1.000
cardiac chamber development GO:0003205 108 1.000
mitral valve morphogenesis GO:0003183 4 1.000
av node cell to bundle of his cell communication GO:0086067 2 1.000
regionalization GO:0003002 337 1.000
septum primum development GO:0003284 4 1.000
endodermal cell fate specification GO:0001714 4 1.000
embryonic heart tube left right pattern formation GO:0060971 5 1.000
cardiac septum development GO:0003279 59 1.000
Human
cardiac chamber morphogenesis GO:0003206 93 1.000
atrial septum primum morphogenesis GO:0003289 3 1.000
cardiac muscle cell differentiation GO:0055007 69 1.000
heart growth GO:0060419 45 1.000
pituitary gland development GO:0021983 38 1.000
Mouse
positive regulation of transcription from rna polymerase ii promoter involved in myocardial precursor cell differentiation GO:0003257 3 1.000
clara cell differentiation GO:0060486 4 1.000
Mouse
positive regulation of cardiac muscle cell proliferation GO:0060045 15 1.000
atrioventricular valve morphogenesis GO:0003181 13 1.000
atrial septum development GO:0003283 12 1.000
Human
forebrain neuron fate commitment GO:0021877 13 1.000
Mouse
heart valve development GO:0003170 23 1.000
epithelial tube morphogenesis GO:0060562 303 1.000
heart contraction GO:0060047 93 1.000
aortic valve morphogenesis GO:0003180 4 1.000
regulation of heart growth GO:0060420 31 1.000
ventricular septum morphogenesis GO:0060412 27 1.000
Human
cardiac atrium development GO:0003230 24 1.000
Human
embryonic heart tube anterior posterior pattern specification GO:0035054 3 1.000
proepicardium development GO:0003342 2 1.000
cardiac muscle cell contraction GO:0086003 7 1.000
heart valve morphogenesis GO:0003179 21 1.000
positive regulation of auditory receptor cell differentiation GO:0045609 1 1.000
ventricular septum development GO:0003281 42 1.000
Human
regulation of cardiac muscle contraction GO:0055117 21 1.000
atrial septum morphogenesis GO:0060413 11 1.000
Human
muscle tissue development GO:0060537 308 1.000
heart process GO:0003015 94 0.999
determination of heart left right asymmetry GO:0061371 48 0.999
positive regulation of heart growth GO:0060421 18 0.999
his purkinje system cell differentiation GO:0060932 2 0.999
telencephalon development GO:0021537 186 0.999
Mouse
endocardial cushion to mesenchymal transition GO:0090500 5 0.999
notochord formation GO:0014028 5 0.999
positive regulation of striated muscle tissue development GO:0045844 31 0.999
blood circulation GO:0008015 195 0.999
positive regulation of cardiac muscle tissue development GO:0055025 19 0.999
pulmonary valve development GO:0003177 5 0.999
striated muscle cell proliferation GO:0014855 39 0.999
embryonic placenta development GO:0001892 98 0.999
stem cell differentiation GO:0048863 268 0.999
cardiac pacemaker cell differentiation GO:0060920 5 0.999
cell proliferation involved in outflow tract morphogenesis GO:0061325 4 0.999
positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation GO:2000802 1 0.999
atrial cardiac muscle cell differentiation GO:0055011 2 0.999
Mouse
positive regulation of transcription from rna polymerase ii promoter involved in heart development GO:1901228 4 0.999
embryonic heart tube development GO:0035050 65 0.999
endocardial cushion morphogenesis GO:0003203 18 0.999
cardiac ventricle morphogenesis GO:0003208 50 0.999
organ growth GO:0035265 117 0.999
regulation of striated muscle contraction GO:0006942 25 0.999
regulation of cardiac chamber formation GO:1901210 1 0.999
outflow tract morphogenesis GO:0003151 53 0.998
embryonic heart tube morphogenesis GO:0003143 51 0.998
cell migration involved in heart formation GO:0060974 1 0.998
neuron projection guidance GO:0097485 141 0.998
Mouse
specification of organ identity GO:0010092 30 0.998
glial cell derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation GO:2000701 1 0.998
mesodermal to mesenchymal transition involved in gastrulation GO:0060809 1 0.998
heart valve formation GO:0003188 10 0.998
cardiac muscle tissue morphogenesis GO:0055008 44 0.998
positive regulation of secondary heart field cardioblast proliferation GO:0072513 4 0.998
atrioventricular valve formation GO:0003190 5 0.998
carbon catabolite repression of transcription from rna polymerase ii promoter GO:0000437 1 0.998
sinoatrial node development GO:0003163 4 0.998
endocrine system development GO:0035270 98 0.998
stem cell development GO:0048864 219 0.998
positive regulation of inner ear receptor cell differentiation GO:2000982 1 0.998
circulatory system process GO:0003013 197 0.998
cell communication involved in cardiac conduction GO:0086065 9 0.998
gland development GO:0048732 330 0.998
negative regulation of cardiac chamber morphogenesis GO:1901220 2 0.997
ventricular cardiac muscle cell development GO:0055015 11 0.997
endocardial cushion formation GO:0003272 13 0.997
muscle tissue morphogenesis GO:0060415 53 0.997
positive regulation of ureteric bud formation GO:0072107 3 0.997
cardiac neural crest cell migration involved in outflow tract morphogenesis GO:0003253 3 0.997
cardiac myofibril assembly GO:0055003 12 0.997
gabaergic neuron differentiation GO:0097154 11 0.997
Mouse
skeletal muscle cell differentiation GO:0035914 66 0.997
regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation GO:2000702 1 0.997
respiratory system development GO:0060541 190 0.997
Mouse
cardiac chamber formation GO:0003207 10 0.997
muscle cell differentiation GO:0042692 261 0.997
ventricular cardiac myofibril assembly GO:0055005 3 0.997
cardiac septum morphogenesis GO:0060411 46 0.997
Human
cardiac cell development GO:0055006 41 0.997
embryonic heart tube formation GO:0003144 1 0.997
mitral valve development GO:0003174 4 0.997
lung development GO:0030324 164 0.996
Mouse
cardiac muscle contraction GO:0060048 32 0.996
foramen ovale closure GO:0035922 1 0.996
cell fate specification GO:0001708 72 0.996
Mouse
visceral motor neuron differentiation GO:0021524 3 0.996
cardiac muscle hypertrophy in response to stress GO:0014898 10 0.995
cell fate commitment involved in formation of primary germ layer GO:0060795 26 0.995
lens morphogenesis in camera type eye GO:0002089 24 0.995
diencephalon development GO:0021536 63 0.995
Mouse
lung lobe formation GO:0060464 1 0.995
transcriptional activation by promoter enhancer looping GO:0071733 2 0.995
heart formation GO:0060914 16 0.995
axonogenesis GO:0007409 274 0.995
Mouse
autonomic nervous system development GO:0048483 43 0.995
megakaryocyte differentiation GO:0030219 26 0.994
negative regulation of cell proliferation GO:0008285 296 0.994
Mouse
regulation of ureteric bud formation GO:0072106 3 0.994
negative regulation of cardiac muscle tissue development GO:0055026 8 0.994
pyramidal neuron migration GO:0021852 1 0.994
positive regulation of transcription via serum response element binding GO:0010735 1 0.994
cardiac conduction GO:0061337 17 0.994
fibroblast growth factor receptor signaling pathway involved in ureteric bud formation GO:2000699 1 0.994
negative regulation of glial cell derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation GO:2000734 1 0.993
ventricular cardiac muscle tissue morphogenesis GO:0055010 32 0.993
neural crest cell development GO:0014032 48 0.993
regulation of organ morphogenesis GO:2000027 144 0.993
regulation of organ growth GO:0046620 61 0.993
atrioventricular bundle cell differentiation GO:0003167 1 0.993
trophectodermal cell differentiation GO:0001829 21 0.993
atrioventricular valve development GO:0003171 15 0.993
ventral spinal cord development GO:0021517 48 0.993
Mouse
camera type eye development GO:0043010 266 0.993
skeletal muscle organ development GO:0060538 163 0.992
regulation of neuron differentiation GO:0045664 281 0.992
Human Mouse
determination of left right symmetry GO:0007368 80 0.992
regulation of skeletal muscle fiber differentiation GO:1902809 3 0.992
positive regulation of transcription from rna polymerase ii promoter involved in norepinephrine biosynthetic process GO:2000763 1 0.992
mast cell differentiation GO:0060374 5 0.992
cardiac muscle cell action potential involved in contraction GO:0086002 6 0.992
heart field specification GO:0003128 6 0.992
muscle cell proliferation GO:0033002 52 0.992
outflow tract septum morphogenesis GO:0003148 11 0.992
Human
positive regulation of muscle tissue development GO:1901863 32 0.992
regulation of heart contraction GO:0008016 77 0.991
cerebral cortex neuron differentiation GO:0021895 19 0.991
Mouse
positive regulation of nervous system development GO:0051962 221 0.991
Human Mouse
endocardial cushion development GO:0003197 26 0.991
cell differentiation in spinal cord GO:0021515 53 0.990
Mouse
regulation of cell proliferation involved in mesonephros development GO:2000606 1 0.990
t cell activation GO:0042110 289 0.990
Mouse
blood vessel morphogenesis GO:0048514 285 0.990
cardiac atrium morphogenesis GO:0003209 23 0.989
Human
sinoatrial node cell development GO:0060931 3 0.989
cardiac epithelial to mesenchymal transition GO:0060317 18 0.989
spinal cord motor neuron differentiation GO:0021522 35 0.989
Mouse
pulmonary valve morphogenesis GO:0003184 5 0.989
regulation of cardiac chamber morphogenesis GO:1901219 2 0.989
morphogenesis of a branching structure GO:0001763 203 0.989
cardiac ventricle development GO:0003231 83 0.989
mesenchymal cell proliferation involved in ureter development GO:0072198 4 0.989
pancreatic pp cell fate commitment GO:0003329 2 0.989
Mouse
thyroid stimulating hormone secreting cell differentiation GO:0060129 4 0.988
cardiac left ventricle morphogenesis GO:0003214 9 0.988
ear development GO:0043583 200 0.988
Mouse
nephron epithelium morphogenesis GO:0072088 68 0.988
positive regulation of transcription elongation from rna polymerase ii promoter GO:0032968 2 0.987
telencephalon regionalization GO:0021978 14 0.987
mesoderm morphogenesis GO:0048332 64 0.986
nephron morphogenesis GO:0072028 69 0.986
forebrain neuron differentiation GO:0021879 52 0.986
Mouse
cell type specific apoptotic process GO:0097285 268 0.986
regulation of forebrain neuron differentiation GO:2000977 2 0.986
response to retinoic acid GO:0032526 56 0.986
digestive system development GO:0055123 200 0.986
Mouse Worm
regulation of gliogenesis GO:0014013 50 0.986
Mouse
ventricular cardiac muscle tissue development GO:0003229 38 0.986
cardiac left ventricle formation GO:0003218 1 0.985
regulation of endocardial cushion to mesenchymal transition involved in heart valve formation GO:2000800 1 0.985
hindbrain development GO:0030902 128 0.984
cell fate commitment GO:0045165 210 0.984
blastocyst formation GO:0001825 33 0.984
mammary gland morphogenesis GO:0060443 54 0.983
oligodendrocyte development GO:0014003 20 0.983
Mouse
gene looping GO:0090202 2 0.983
negative regulation of cardiac chamber formation GO:1901211 1 0.983
negative regulation of neuron differentiation GO:0045665 101 0.983
Mouse
mesodermal cell migration GO:0008078 4 0.982
forebrain regionalization GO:0021871 25 0.982
Mouse
lung cell differentiation GO:0060479 30 0.981
Mouse
cardiac ventricle formation GO:0003211 8 0.981
mesenchymal cell development GO:0014031 93 0.980
muscle system process GO:0003012 141 0.980
chemotaxis GO:0006935 247 0.980
Mouse
formation of primary germ layer GO:0001704 77 0.979
cerebral cortex development GO:0021987 86 0.979
Mouse
auditory receptor cell fate determination GO:0042668 3 0.979
neural crest cell differentiation GO:0014033 54 0.979
branching involved in mammary gland duct morphogenesis GO:0060444 27 0.978
epithelial cell proliferation GO:0050673 174 0.978
Mouse
neural crest cell migration GO:0001755 32 0.978
skeletal system development GO:0001501 356 0.978
Mouse
secondary heart field specification GO:0003139 6 0.978
regulation of cardiac muscle cell contraction GO:0086004 11 0.978
glandular epithelial cell differentiation GO:0002067 38 0.978
Mouse
negative regulation of canonical wnt signaling pathway involved in neural plate anterior posterior pattern formation GO:0060829 1 0.978
digestive tract morphogenesis GO:0048546 147 0.977
Mouse
vagus nerve development GO:0021564 3 0.977
mesenchymal cell differentiation GO:0048762 107 0.977
negative regulation of muscle cell apoptotic process GO:0010656 9 0.977
hemangioblast cell differentiation GO:0060217 1 0.977
coronary vasculature development GO:0060976 12 0.976
embryonic skeletal system development GO:0048706 120 0.976
Mouse
cardiac right ventricle formation GO:0003219 3 0.975
enamel mineralization GO:0070166 7 0.975
response to fibroblast growth factor GO:0071774 47 0.974
aorta morphogenesis GO:0035909 22 0.974
pallium development GO:0021543 120 0.974
Mouse
negative regulation of mesodermal cell fate specification GO:0042662 3 0.974
appendage morphogenesis GO:0035107 149 0.974
nodal signaling pathway involved in determination of left right asymmetry GO:0038107 2 0.974
regulation of renin secretion into blood stream GO:1900133 4 0.974
sa node cell to atrial cardiac muscle cell signalling GO:0086018 4 0.973
epidermis development GO:0008544 187 0.973
cell communication by electrical coupling involved in cardiac conduction GO:0086064 2 0.972
leukocyte differentiation GO:0002521 342 0.972
Mouse
negative regulation of heart looping GO:1901208 1 0.972
positive regulation of glial cell differentiation GO:0045687 21 0.972
Mouse
ear morphogenesis GO:0042471 118 0.972
Mouse
morphogenesis of a branching epithelium GO:0061138 193 0.971
bone morphogenesis GO:0060349 78 0.971
regulation of striated muscle cell differentiation GO:0051153 81 0.971
Human
alpha beta t cell differentiation GO:0046632 69 0.971
Mouse
regulation of ventricular cardiac muscle cell membrane depolarization GO:0060373 2 0.971
regulation of organ formation GO:0003156 34 0.970
muscle adaptation GO:0043500 39 0.970
regulation of tongue muscle cell differentiation GO:2001035 2 0.970
endoderm formation GO:0001706 20 0.970
embryonic epithelial tube formation GO:0001838 130 0.970
positive regulation of skeletal muscle fiber differentiation GO:1902811 2 0.970
cardiac pacemaker cell development GO:0060926 5 0.970
negative regulation of wnt signaling pathway GO:0030178 73 0.968
positive regulation of skeletal muscle cell differentiation GO:2001016 4 0.968
negative regulation of wnt signaling pathway involved in heart development GO:0003308 4 0.968
regulation of heart morphogenesis GO:2000826 22 0.967
digestive tract development GO:0048565 190 0.967
Mouse Worm
cell differentiation involved in embryonic placenta development GO:0060706 26 0.967
heart trabecula formation GO:0060347 14 0.966
embryonic eye morphogenesis GO:0048048 29 0.966
epithelial to mesenchymal transition involved in endocardial cushion formation GO:0003198 10 0.966
regulation of definitive erythrocyte differentiation GO:0010724 3 0.966
semaphorin plexin signaling pathway involved in outflow tract morphogenesis GO:0071527 1 0.965
regulation of auditory receptor cell differentiation GO:0045607 4 0.965
epithelial tube formation GO:0072175 130 0.965
cardiac cell fate commitment GO:0060911 10 0.965
regulation of glial cell differentiation GO:0045685 41 0.964
Mouse
nephron tubule morphogenesis GO:0072078 68 0.963
nephron tubule epithelial cell differentiation GO:0072160 11 0.963
negative regulation of gastrulation GO:2000542 3 0.963
definitive erythrocyte differentiation GO:0060318 7 0.963
sensory organ morphogenesis GO:0090596 242 0.962
Mouse
limbic system development GO:0021761 72 0.962
Mouse
positive regulation of tongue muscle cell differentiation GO:2001037 2 0.961
regulation of cell activation GO:0050865 289 0.960
mesonephric tubule morphogenesis GO:0072171 63 0.960
astrocyte fate commitment GO:0060018 4 0.960
regulation of cardioblast proliferation GO:0003264 9 0.960
somite rostral caudal axis specification GO:0032525 13 0.959
regulation of transcription from rna polymerase ii promoter involved in myocardial precursor cell differentiation GO:0003256 6 0.959
pulmonary valve formation GO:0003193 1 0.959
lens development in camera type eye GO:0002088 62 0.958
cell proliferation in hindbrain GO:0021534 10 0.958
thymus development GO:0048538 41 0.957
regulation of endodermal cell differentiation GO:1903224 2 0.956
cell migration involved in gastrulation GO:0042074 13 0.956
regulation of muscle tissue development GO:1901861 97 0.956
negative regulation of neuron projection development GO:0010977 50 0.956
muscle cell development GO:0055001 133 0.954
positive regulation of heart rate GO:0010460 10 0.954
t cell differentiation GO:0030217 174 0.954
Mouse
endodermal cell fate determination GO:0007493 2 0.953
respiratory tube development GO:0030323 167 0.953
Mouse
lung epithelial cell differentiation GO:0060487 29 0.952
Mouse
endoderm development GO:0007492 45 0.951
Mouse
positive regulation of mechanoreceptor differentiation GO:0045633 1 0.951
regulation of canonical wnt signaling pathway involved in neural plate anterior posterior pattern formation GO:0060827 1 0.950
nodal signaling pathway involved in determination of lateral mesoderm left right asymmetry GO:1900164 2 0.950
regulation of nephron tubule epithelial cell differentiation GO:0072182 9 0.949
sa node cell action potential GO:0086015 4 0.949
positive regulation of semaphorin plexin signaling pathway involved in outflow tract morphogenesis GO:2000764 1 0.948
parathyroid hormone secretion GO:0035898 2 0.948
striated muscle cell development GO:0055002 125 0.948
negative regulation of nervous system development GO:0051961 156 0.947
Mouse
cell adhesion GO:0007155 329 0.947
negative regulation of macrophage differentiation GO:0045650 4 0.947
mesenchymal cell proliferation GO:0010463 44 0.946
limb development GO:0060173 166 0.945
cerebral cortex cell migration GO:0021795 44 0.945
Mouse
coronary vasculature morphogenesis GO:0060977 9 0.945
urogenital system development GO:0001655 261 0.944
erythrocyte differentiation GO:0030218 88 0.944
regulation of glial cell derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation GO:2000733 1 0.943
specification of organ position GO:0010159 3 0.943
positive regulation of mesenchymal cell proliferation GO:0002053 33 0.943
ureter maturation GO:0035799 4 0.941
canonical wnt signaling pathway involved in neural plate anterior posterior pattern formation GO:0060823 1 0.941
negative regulation of cardiac muscle cell proliferation GO:0060044 5 0.941
oligodendrocyte differentiation GO:0048709 53 0.941
Mouse
atrioventricular node cell differentiation GO:0060922 2 0.939
face morphogenesis GO:0060325 29 0.939
wnt signaling pathway involved in kidney development GO:0061289 2 0.938
stem cell maintenance GO:0019827 130 0.937
mesoderm formation GO:0001707 62 0.937
regulation of blood circulation GO:1903522 93 0.936
neural tube closure GO:0001843 90 0.936
regulation of neuron maturation GO:0014041 5 0.936
visceral serous pericardium development GO:0061032 2 0.936
apoptotic process involved in outflow tract morphogenesis GO:0003275 2 0.936
tendon cell differentiation GO:0035990 4 0.936
cranial nerve development GO:0021545 41 0.936
forebrain development GO:0030900 302 0.935
Mouse
spinal cord development GO:0021510 81 0.935
Mouse
ventricular trabecula myocardium morphogenesis GO:0003222 11 0.935
central nervous system neuron differentiation GO:0021953 162 0.934
Mouse
cardiac right ventricle morphogenesis GO:0003215 13 0.933
Human
renal vesicle development GO:0072087 17 0.933
regulation of mast cell differentiation GO:0060375 3 0.933
glial cell development GO:0021782 54 0.933
Mouse
positive regulation of epithelial cell proliferation involved in lung morphogenesis GO:0060501 3 0.933
regulation of heart looping GO:1901207 1 0.932
his purkinje system development GO:0003164 4 0.931
ameboidal type cell migration GO:0001667 128 0.931
milk ejection GO:0060156 1 0.930
lymphocyte differentiation GO:0030098 242 0.930
Mouse
positive regulation of neuron differentiation GO:0045666 141 0.930
Human Mouse
cardiac muscle adaptation GO:0014887 10 0.930
regulation of membrane depolarization GO:0003254 11 0.929
cell fate determination GO:0001709 32 0.928
Mouse
otic vesicle development GO:0071599 14 0.928
forebrain generation of neurons GO:0021872 63 0.928
Mouse
positive regulation of epithelial cell proliferation GO:0050679 68 0.928
neuron migration GO:0001764 122 0.928
Mouse
metanephric capsule specification GO:0072267 1 0.927
hypothalamus development GO:0021854 16 0.927
Mouse
enteroendocrine cell differentiation GO:0035883 16 0.927
Mouse
spleen development GO:0048536 39 0.927
cardiac muscle cell fate commitment GO:0060923 6 0.927
regulation of epithelial cell proliferation GO:0050678 141 0.926
Mouse
atrioventricular node cell development GO:0060928 2 0.926
atrial cardiac muscle cell development GO:0055014 2 0.925
Mouse
regulation of cell proliferation involved in heart morphogenesis GO:2000136 15 0.924
endodermal cell differentiation GO:0035987 14 0.924
muscle hypertrophy GO:0014896 24 0.924
columnar cuboidal epithelial cell differentiation GO:0002065 82 0.923
Mouse
regulation of membrane depolarization during cardiac muscle cell action potential GO:1900825 1 0.923
male sex differentiation GO:0046661 109 0.921
Mouse
mammary gland duct morphogenesis GO:0060603 38 0.921
negative regulation of embryonic development GO:0045992 22 0.920
platelet morphogenesis GO:0036344 13 0.920
regulation of wnt signaling pathway GO:0030111 123 0.919
aortic valve development GO:0003176 5 0.919
cell migration involved in heart development GO:0060973 8 0.918
regulation of transcription from rna polymerase ii promoter involved in determination of left right symmetry GO:1900094 2 0.916
auditory receptor cell fate specification GO:0042667 1 0.915
myelination GO:0042552 74 0.915
cation homeostasis GO:0055080 212 0.915
closure of optic fissure GO:0061386 2 0.913
regulation of apoptotic process involved in outflow tract morphogenesis GO:1902256 2 0.913
ureteric bud morphogenesis GO:0060675 62 0.913
somitogenesis GO:0001756 69 0.913
kidney morphogenesis GO:0060993 83 0.912
cellular response to follicle stimulating hormone stimulus GO:0071372 1 0.909
regulation of neuron projection development GO:0010975 169 0.909
cell communication by chemical coupling GO:0010643 2 0.908
myotube differentiation GO:0014902 105 0.908
Human
fibroblast growth factor receptor signaling pathway GO:0008543 46 0.907
atrioventricular canal development GO:0036302 5 0.906
actin mediated cell contraction GO:0070252 15 0.906
vascular smooth muscle cell differentiation GO:0035886 11 0.906
negative regulation of apoptotic process involved in outflow tract morphogenesis GO:1902257 2 0.904
purkinje myocyte differentiation GO:0003168 1 0.904
embryonic camera type eye development GO:0031076 36 0.903
regulation of cell migration GO:0030334 219 0.903
negative regulation of epithelial cell proliferation GO:0050680 64 0.903
Mouse
regulation of atrial cardiac muscle cell membrane depolarization GO:0060371 5 0.901
lung saccule development GO:0060430 7 0.901
Mouse
renal capsule specification GO:0072130 1 0.897
embryonic viscerocranium morphogenesis GO:0048703 8 0.897
tube formation GO:0035148 140 0.895
negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation GO:2000703 1 0.895
notochord development GO:0030903 20 0.895
renal system development GO:0072001 225 0.895
placenta development GO:0001890 140 0.893
regulation of transcription involved in primary germ layer cell fate commitment GO:0060796 2 0.893
positive regulation of blood circulation GO:1903524 22 0.893
cardiac muscle cell myoblast differentiation GO:0060379 8 0.891
myofibril assembly GO:0030239 34 0.890
hindlimb morphogenesis GO:0035137 42 0.888
tongue development GO:0043586 18 0.887
Mouse
regulation of canonical wnt signaling pathway GO:0060828 82 0.885
myeloid cell homeostasis GO:0002262 114 0.884
branching morphogenesis of an epithelial tube GO:0048754 159 0.883
cardiac muscle cell action potential GO:0086001 11 0.883
olfactory bulb development GO:0021772 30 0.883
cellular response to fibroblast growth factor stimulus GO:0044344 47 0.880
positive regulation of stem cell differentiation GO:2000738 23 0.879
spinal cord oligodendrocyte cell differentiation GO:0021529 3 0.878
Mouse
cell differentiation involved in kidney development GO:0061005 33 0.877
regulation of secondary heart field cardioblast proliferation GO:0003266 9 0.877
positive regulation of transcription regulatory region dna binding GO:2000679 1 0.875
negative regulation of mesenchymal cell apoptotic process GO:2001054 11 0.874
mesenchyme morphogenesis GO:0072132 32 0.871
lung induction GO:0060492 3 0.871
regulation of histone h3 k4 methylation GO:0051569 12 0.869
muscle contraction GO:0006936 101 0.867
mesodermal cell fate commitment GO:0001710 17 0.867
cellular response to retinoic acid GO:0071300 25 0.867
pancreatic a cell differentiation GO:0003310 7 0.867
Mouse
vagus nerve morphogenesis GO:0021644 2 0.866
olfactory lobe development GO:0021988 32 0.865
tendon formation GO:0035992 4 0.864
glial cell fate commitment GO:0021781 14 0.864
Mouse
positive regulation of mesenchymal cell proliferation involved in ureter development GO:2000729 3 0.864
regulation of epithelial cell differentiation involved in kidney development GO:2000696 10 0.863
positive regulation of transcription from rna polymerase ii promoter by glucose GO:0000432 3 0.863
hepaticobiliary system development GO:0061008 67 0.861
primary prostatic bud elongation GO:0060516 2 0.859
central nervous system morphogenesis GO:0021551 2 0.859
bmp signaling pathway GO:0030509 93 0.859
forelimb morphogenesis GO:0035136 40 0.859
detection of external stimulus GO:0009581 61 0.857
comma shaped body morphogenesis GO:0072049 5 0.857
regulation of transcription from rna polymerase ii promoter involved in ventral spinal cord interneuron specification GO:0021913 4 0.855
positive regulation of cell activation GO:0050867 158 0.854
septum secundum development GO:0003285 1 0.854
Human
developmental growth involved in morphogenesis GO:0060560 138 0.853
retinoic acid receptor signaling pathway GO:0048384 17 0.852
mammary placode formation GO:0060596 4 0.852
regulation of heart rate GO:0002027 36 0.851
negative regulation of neural precursor cell proliferation GO:2000178 18 0.851
renal tubule morphogenesis GO:0061333 72 0.849
head morphogenesis GO:0060323 34 0.847
skeletal muscle fiber development GO:0048741 58 0.847
positive regulation of transcription by glucose GO:0046016 3 0.847
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.846
cell surface receptor signaling pathway involved in heart development GO:0061311 15 0.845
positive regulation of protein phosphorylation GO:0001934 242 0.845
wnt signaling pathway GO:0016055 188 0.845
epithelial cell differentiation involved in kidney development GO:0035850 23 0.845
odontogenesis of dentin containing tooth GO:0042475 66 0.844
Mouse
response to bmp GO:0071772 14 0.843
nephric duct formation GO:0072179 4 0.843
morphogenesis of embryonic epithelium GO:0016331 159 0.843
regulation of myotube differentiation GO:0010830 62 0.841
Human
regulation of epidermal cell differentiation GO:0045604 21 0.841
regulation of endodermal cell fate specification GO:0042663 2 0.840
type ii pneumocyte differentiation GO:0060510 7 0.840
Mouse
regulation of system process GO:0044057 200 0.838
regulation of osteoblast differentiation GO:0045667 67 0.836
tongue muscle cell differentiation GO:0035981 2 0.836
pulmonary myocardium development GO:0003350 3 0.836
skeletal system morphogenesis GO:0048705 203 0.835
Mouse
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 40 0.835
tongue morphogenesis GO:0043587 8 0.834
regulation of membrane depolarization during action potential GO:0098902 1 0.834
left right pattern formation GO:0060972 23 0.832

Nkx2-5 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
heart disease DOID:114 0 0.999
Human
disease of anatomical entity DOID:7 0 0.999
Human
cardiovascular system disease DOID:1287 0 0.999
Human
congenital heart disease DOID:1682 0 0.987
Human
heart septal defect DOID:1681 0 0.987
Human
ventricular septal defect DOID:1657 0 0.987
Human