Mus musculus

187 known processes

Nkx6-1

NK6 homeobox 1

(Aliases: NKX6A,Nkx6.1)

Nkx6-1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
ventral spinal cord interneuron fate commitment GO:0060579 14 0.961
pancreatic pp cell differentiation GO:0003312 2 0.876
pancreatic a cell fate commitment GO:0003326 2 0.873
spinal cord oligodendrocyte cell fate specification GO:0021530 3 0.851
cell fate commitment GO:0045165 210 0.823
globus pallidus development GO:0021759 2 0.801
pancreatic pp cell fate commitment GO:0003329 2 0.798
type b pancreatic cell differentiation GO:0003309 13 0.795
Zebrafish Rat
ventricular cardiac myofibril assembly GO:0055005 3 0.793
regionalization GO:0003002 337 0.782
transdifferentiation GO:0060290 1 0.778
spinal cord development GO:0021510 81 0.758
skeletal system morphogenesis GO:0048705 203 0.752
atrial cardiac muscle cell development GO:0055014 2 0.744
connective tissue development GO:0061448 179 0.743
embryonic skeletal system development GO:0048706 120 0.687
sensory organ morphogenesis GO:0090596 242 0.681
spleen development GO:0048536 39 0.680
extracellular matrix organization GO:0030198 147 0.673
nephron tubule development GO:0072080 84 0.668
positive regulation of neuron differentiation GO:0045666 141 0.649
bmp signaling pathway GO:0030509 93 0.649
regulation of neuron projection development GO:0010975 169 0.639
metencephalon development GO:0022037 89 0.639
axonogenesis GO:0007409 274 0.639
camera type eye development GO:0043010 266 0.632
forebrain development GO:0030900 302 0.623
positive regulation of transcription via serum response element binding GO:0010735 1 0.614
atrial cardiac muscle cell differentiation GO:0055011 2 0.608
positive regulation of cell development GO:0010720 237 0.589
ureteric bud morphogenesis GO:0060675 62 0.588
astrocyte fate commitment GO:0060018 4 0.588
positive regulation of stem cell differentiation GO:2000738 23 0.579
regulation of system process GO:0044057 200 0.579
neuron fate specification GO:0048665 30 0.578
embryonic appendage morphogenesis GO:0035113 126 0.569
renal tubule development GO:0061326 87 0.568
regulation of cardioblast differentiation GO:0051890 3 0.566
spinal cord oligodendrocyte cell differentiation GO:0021529 3 0.561
kidney epithelium development GO:0072073 121 0.558
cell fate determination GO:0001709 32 0.552
Mouse
pancreatic a cell differentiation GO:0003310 7 0.551
Zebrafish
embryonic limb morphogenesis GO:0030326 126 0.547
limb morphogenesis GO:0035108 149 0.537
myeloid cell differentiation GO:0030099 233 0.534
cardiac pacemaker cell fate commitment GO:0060927 1 0.531
cerebral cortex development GO:0021987 86 0.528
negative regulation of nervous system development GO:0051961 156 0.528
stem cell development GO:0048864 219 0.516
kidney morphogenesis GO:0060993 83 0.509
amide transport GO:0042886 138 0.509
Rat
spinal cord motor neuron cell fate specification GO:0021520 13 0.500
ion transmembrane transport GO:0034220 361 0.499
regulation of neuron differentiation GO:0045664 281 0.492
endocrine system development GO:0035270 98 0.488
dendrite development GO:0016358 115 0.463
columnar cuboidal epithelial cell differentiation GO:0002065 82 0.458
Zebrafish Mouse Rat
negative regulation of neuron differentiation GO:0045665 101 0.453
ear morphogenesis GO:0042471 118 0.447
muscle tissue development GO:0060537 308 0.446
development of primary male sexual characteristics GO:0046546 88 0.443
forebrain regionalization GO:0021871 25 0.442
endocrine pancreas development GO:0031018 29 0.442
male sex differentiation GO:0046661 109 0.441
ventral spinal cord interneuron differentiation GO:0021514 16 0.439
extracellular structure organization GO:0043062 148 0.436
nephron tubule morphogenesis GO:0072078 68 0.435
motor neuron migration GO:0097475 4 0.430
spinal cord dorsal ventral patterning GO:0021513 23 0.428
forebrain neuron fate commitment GO:0021877 13 0.426
smoothened signaling pathway GO:0007224 105 0.423
atrioventricular node cell development GO:0060928 2 0.421
ventral spinal cord interneuron specification GO:0021521 11 0.419
cell cell signaling involved in cell fate commitment GO:0045168 35 0.418
purkinje myocyte differentiation GO:0003168 1 0.415
heart trabecula formation GO:0060347 14 0.411
glucose homeostasis GO:0042593 128 0.409
cellular response to monosaccharide stimulus GO:0071326 47 0.407
spinal cord patterning GO:0021511 25 0.402
mesonephric tubule development GO:0072164 94 0.402
cell differentiation in spinal cord GO:0021515 53 0.399
retinal bipolar neuron differentiation GO:0060040 5 0.397
clara cell differentiation GO:0060486 4 0.396
primary neural tube formation GO:0014020 95 0.393
nephron epithelium morphogenesis GO:0072088 68 0.391
cell fate specification involved in pattern specification GO:0060573 11 0.390
auditory receptor cell fate determination GO:0042668 3 0.385
atrioventricular node cell fate commitment GO:0060929 1 0.381
positive regulation of transcription initiation from rna polymerase ii promoter GO:0060261 5 0.375
ventral spinal cord interneuron fate determination GO:0060580 1 0.373
skeletal muscle cell differentiation GO:0035914 66 0.367
his purkinje system development GO:0003164 4 0.361
paraxial mesodermal cell differentiation GO:0048342 2 0.356
kidney development GO:0001822 213 0.354
olfactory bulb development GO:0021772 30 0.353
ureteric bud development GO:0001657 94 0.351
renal tubule morphogenesis GO:0061333 72 0.350
formation of primary germ layer GO:0001704 77 0.346
regulation of canonical wnt signaling pathway GO:0060828 82 0.346
olfactory lobe development GO:0021988 32 0.342
embryonic placenta development GO:0001892 98 0.340
regulation of wnt signaling pathway GO:0030111 123 0.340
planar cell polarity pathway involved in cardiac right atrium morphogenesis GO:0061349 2 0.337
embryonic epithelial tube formation GO:0001838 130 0.337
cardiac chamber morphogenesis GO:0003206 93 0.336
skeletal system development GO:0001501 356 0.336
positive regulation of auditory receptor cell differentiation GO:0045609 1 0.336
mesenchyme development GO:0060485 152 0.336
mesenchymal cell development GO:0014031 93 0.330
regulation of voltage gated calcium channel activity GO:1901385 4 0.330
enteroendocrine cell differentiation GO:0035883 16 0.328
Zebrafish Rat
nephron morphogenesis GO:0072028 69 0.325
tendon cell differentiation GO:0035990 4 0.323
development of primary sexual characteristics GO:0045137 143 0.321
Worm
telencephalon development GO:0021537 186 0.319
his purkinje system cell differentiation GO:0060932 2 0.318
columnar cuboidal epithelial cell development GO:0002066 29 0.314
Rat
positive regulation of nervous system development GO:0051962 221 0.313
central nervous system neuron differentiation GO:0021953 162 0.311
regulation of auditory receptor cell differentiation GO:0045607 4 0.310
respiratory tube development GO:0030323 167 0.309
regulation of chondrocyte differentiation GO:0032330 33 0.303
regulation of stem cell differentiation GO:2000736 50 0.302
muscle cell development GO:0055001 133 0.299
mesonephros development GO:0001823 97 0.297
negative regulation of cell development GO:0010721 169 0.292
urogenital system development GO:0001655 261 0.288
positive regulation of dna templated transcription initiation GO:2000144 5 0.287
actin cytoskeleton organization GO:0030036 220 0.286
limb development GO:0060173 166 0.286
inorganic ion transmembrane transport GO:0098660 234 0.286
regulation of organ morphogenesis GO:2000027 144 0.284
cerebellum development GO:0021549 77 0.280
insulin secretion GO:0030073 89 0.279
Rat
atrioventricular node cell differentiation GO:0060922 2 0.276
negative regulation of type b pancreatic cell apoptotic process GO:2000675 3 0.274
neuron migration GO:0001764 122 0.273
pulmonary myocardium development GO:0003350 3 0.272
positive regulation of inner ear receptor cell differentiation GO:2000982 1 0.268
determination of left right symmetry GO:0007368 80 0.265
Worm
epithelial tube morphogenesis GO:0060562 303 0.265
circulatory system process GO:0003013 197 0.265
cation transmembrane transport GO:0098655 266 0.265
paraxial mesodermal cell fate commitment GO:0048343 2 0.264
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.263
neuron projection guidance GO:0097485 141 0.263
odontogenesis of dentin containing tooth GO:0042475 66 0.262
muscle tissue morphogenesis GO:0060415 53 0.262
left right pattern formation GO:0060972 23 0.262
regulation of cardiac muscle cell proliferation GO:0060043 23 0.262
cardiac neural crest cell migration involved in outflow tract morphogenesis GO:0003253 3 0.258
embryonic organ morphogenesis GO:0048562 276 0.255
diencephalon development GO:0021536 63 0.255
embryonic heart tube left right pattern formation GO:0060971 5 0.253
regulation of cellular amine metabolic process GO:0033238 20 0.253
regulation of peptide hormone secretion GO:0090276 75 0.252
Rat
pericardium development GO:0060039 16 0.252
oligodendrocyte cell fate commitment GO:0021779 5 0.250
myeloid leukocyte differentiation GO:0002573 119 0.249
mesenchymal cell differentiation GO:0048762 107 0.249
epidermis development GO:0008544 187 0.246
chemotaxis GO:0006935 247 0.245
homeostasis of number of cells GO:0048872 210 0.245
regulation of myeloid cell differentiation GO:0045637 96 0.245
developmental induction GO:0031128 34 0.245
somitogenesis GO:0001756 69 0.243
neural tube development GO:0021915 160 0.243
appendage development GO:0048736 166 0.242
inner ear morphogenesis GO:0042472 101 0.242
transmembrane transport GO:0055085 412 0.241
negative regulation of wnt signaling pathway GO:0030178 73 0.241
autonomic nervous system development GO:0048483 43 0.240
cell fate determination involved in pattern specification GO:0060582 1 0.238
response to transforming growth factor beta GO:0071559 88 0.238
respiratory system development GO:0060541 190 0.237
regulation of calcium ion transmembrane transporter activity GO:1901019 20 0.237
nephron epithelium development GO:0072009 92 0.234
glial cell fate commitment GO:0021781 14 0.232
renal system development GO:0072001 225 0.232
mitral valve development GO:0003174 4 0.228
auditory receptor cell fate specification GO:0042667 1 0.228
spinal cord motor neuron differentiation GO:0021522 35 0.227
mesonephric duct morphogenesis GO:0072180 4 0.227
pancreas development GO:0031016 57 0.227
epithelial cell fate commitment GO:0072148 13 0.225
hemangioblast cell differentiation GO:0060217 1 0.221
positive regulation of transcription from rna polymerase ii promoter involved in norepinephrine biosynthetic process GO:2000763 1 0.219
chondrocyte differentiation GO:0002062 72 0.216
hindbrain development GO:0030902 128 0.216
stem cell differentiation GO:0048863 268 0.216
endocardial cushion to mesenchymal transition involved in heart valve formation GO:0003199 4 0.215
metanephric nephron development GO:0072210 34 0.215
embryonic skeletal system morphogenesis GO:0048704 91 0.213
renal vesicle induction GO:0072034 3 0.212
glandular epithelial cell differentiation GO:0002067 38 0.211
Zebrafish Mouse Rat
developmental programmed cell death GO:0010623 41 0.209
hormone secretion GO:0046879 128 0.209
Rat
cell type specific apoptotic process GO:0097285 268 0.209
cell fate commitment involved in pattern specification GO:0060581 14 0.209
cellular component assembly involved in morphogenesis GO:0010927 139 0.207
nephron development GO:0072006 109 0.204
trabecula formation GO:0060343 24 0.204
midbrain hindbrain boundary maturation GO:0021732 1 0.204
male gonad development GO:0008584 88 0.204
organic hydroxy compound metabolic process GO:1901615 203 0.202
apoptotic process involved in morphogenesis GO:0060561 25 0.202
t cell differentiation GO:0030217 174 0.202
spinal cord motor neuron migration GO:0097476 4 0.200
lymphocyte differentiation GO:0030098 242 0.200
b cell activation GO:0042113 161 0.200
muscle cell fate commitment GO:0042693 11 0.199
morphogenesis of embryonic epithelium GO:0016331 159 0.199
heart morphogenesis GO:0003007 178 0.198
cation transport GO:0006812 399 0.196
developmental maturation GO:0021700 193 0.195
negative regulation of cell proliferation GO:0008285 296 0.195
regulation of muscle tissue development GO:1901861 97 0.193
peptide hormone secretion GO:0030072 109 0.192
Rat
canonical wnt signaling pathway GO:0060070 130 0.190
cellular amino acid metabolic process GO:0006520 103 0.189
cardiocyte differentiation GO:0035051 87 0.189
lateral inhibition GO:0046331 1 0.189
midbrain hindbrain boundary maturation during brain development GO:0022004 1 0.188
negative regulation of myeloid cell differentiation GO:0045638 38 0.187
regulation of blood circulation GO:1903522 93 0.186
male gamete generation GO:0048232 285 0.186
positive regulation of insulin secretion GO:0032024 26 0.184
Rat
tendon formation GO:0035992 4 0.183
leukocyte homeostasis GO:0001776 79 0.183
mesoderm formation GO:0001707 62 0.182
organelle assembly GO:0070925 177 0.182
glial cell fate specification GO:0021780 5 0.181
metanephros development GO:0001656 79 0.181
muscle contraction GO:0006936 101 0.180
mesoderm morphogenesis GO:0048332 64 0.179
digestive tract morphogenesis GO:0048546 147 0.179
negative regulation of cellular protein metabolic process GO:0032269 247 0.179
leukocyte differentiation GO:0002521 342 0.178
regulation of peptide secretion GO:0002791 77 0.177
Rat
cardiac ventricle development GO:0003231 83 0.177
regulation of transporter activity GO:0032409 57 0.177
regulation of secretion by cell GO:1903530 249 0.176
Rat
neuron fate determination GO:0048664 9 0.175
glial cell differentiation GO:0010001 131 0.174
positive regulation of cardioblast differentiation GO:0051891 3 0.174
menarche GO:0042696 1 0.174
b cell differentiation GO:0030183 78 0.174
neuroendocrine cell differentiation GO:0061101 7 0.173
outflow tract morphogenesis GO:0003151 53 0.172
cartilage development GO:0051216 140 0.172
regulation of endocardial cushion to mesenchymal transition involved in heart valve formation GO:2000800 1 0.171
negative regulation of canonical wnt signaling pathway GO:0090090 51 0.170
regulation of neural precursor cell proliferation GO:2000177 70 0.170
hippocampus development GO:0021766 52 0.170
regulation of neural retina development GO:0061074 3 0.170
lung development GO:0030324 164 0.169
mesonephric duct formation GO:0072181 2 0.168
multicellular organismal signaling GO:0035637 91 0.167
Mouse
stem cell fate specification GO:0048866 3 0.165
negative regulation of cartilage development GO:0061037 17 0.163
epithelial cell development GO:0002064 159 0.163
Rat
positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation GO:2000802 1 0.161
cellular response to growth factor stimulus GO:0071363 197 0.160
alpha beta t cell differentiation GO:0046632 69 0.160
positive regulation of cell cycle GO:0045787 92 0.159
ventral midline development GO:0007418 4 0.156
positive regulation of protein complex assembly GO:0031334 45 0.155
appendage morphogenesis GO:0035107 149 0.154
placenta development GO:0001890 140 0.151
myoblast differentiation involved in skeletal muscle regeneration GO:0014835 3 0.151
neural crest cell differentiation GO:0014033 54 0.150
axon guidance GO:0007411 141 0.150
heart contraction GO:0060047 93 0.149
glycerolipid metabolic process GO:0046486 122 0.148
fat cell differentiation GO:0045444 160 0.148
gonad development GO:0008406 141 0.147
Worm
pattern specification involved in metanephros development GO:0072268 4 0.147
regulation of protein complex assembly GO:0043254 83 0.146
germ line sex determination GO:0018992 3 0.146
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 68 0.146
regulation of heart contraction GO:0008016 77 0.146
plasma cell differentiation GO:0002317 3 0.144
tube formation GO:0035148 140 0.143
cd4 positive alpha beta t cell activation GO:0035710 45 0.142
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.142
type b pancreatic cell development GO:0003323 10 0.142
Rat
cell fate specification GO:0001708 72 0.141
mitral valve morphogenesis GO:0003183 4 0.141
embryonic heart tube development GO:0035050 65 0.141
wnt signaling pathway involved in forebrain neuroblast division GO:0021874 2 0.140
neural retina development GO:0003407 41 0.139
heart process GO:0003015 94 0.139
regulation of secretion GO:0051046 274 0.138
Rat
regulation of rna polymerase ii transcriptional preinitiation complex assembly GO:0045898 2 0.138
positive regulation of rna polymerase ii transcriptional preinitiation complex assembly GO:0045899 2 0.138
epithelial tube formation GO:0072175 130 0.137
ventricular cardiac muscle cell development GO:0055015 11 0.136
retina morphogenesis in camera type eye GO:0060042 45 0.135
regulation of cellular component biogenesis GO:0044087 181 0.134
middle ear morphogenesis GO:0042474 23 0.133
positive regulation of hormone secretion GO:0046887 38 0.133
Rat
cardiac chamber development GO:0003205 108 0.132
positive regulation of cellular component biogenesis GO:0044089 94 0.131
carbon catabolite repression of transcription from rna polymerase ii promoter GO:0000437 1 0.131
actomyosin structure organization GO:0031032 56 0.131
spermatogenesis GO:0007283 284 0.131
positive regulation of epithelial cell proliferation involved in lung morphogenesis GO:0060501 3 0.130
neural tube closure GO:0001843 90 0.129
positive regulation of cellular amine metabolic process GO:0033240 5 0.127
regulation of bmp signaling pathway GO:0030510 60 0.126
gastrulation GO:0007369 116 0.126
peptide secretion GO:0002790 114 0.126
Rat
regulation of peptide transport GO:0090087 91 0.126
Rat
forebrain neuron differentiation GO:0021879 52 0.125
cerebellum formation GO:0021588 1 0.125
muscle cell differentiation GO:0042692 261 0.125
somatotropin secreting cell differentiation GO:0060126 4 0.125
forebrain generation of neurons GO:0021872 63 0.124
heart growth GO:0060419 45 0.124
nitrogen compound transport GO:0071705 271 0.124
Rat
positive regulation of anagen GO:0051885 1 0.124
regulation of myeloid leukocyte differentiation GO:0002761 58 0.123
cardiac muscle cell development GO:0055013 39 0.123
regulation of asymmetric cell division GO:0009786 4 0.123
cellular response to glucose stimulus GO:0071333 45 0.123
blood circulation GO:0008015 195 0.122
axis elongation involved in somitogenesis GO:0090245 4 0.122
pharynx development GO:0060465 1 0.122
ventricular cardiac muscle cell differentiation GO:0055012 17 0.122
proepicardium development GO:0003342 2 0.122
regulation of stem cell proliferation GO:0072091 78 0.121
visceral serous pericardium development GO:0061032 2 0.121
ventral spinal cord development GO:0021517 48 0.121
peripheral nervous system neuron axonogenesis GO:0048936 3 0.121
cardiac cell development GO:0055006 41 0.120
nephric duct formation GO:0072179 4 0.120
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.119
cardiac myofibril assembly GO:0055003 12 0.119
central nervous system vasculogenesis GO:0022009 3 0.118
gliogenesis GO:0042063 141 0.117
mesonephric epithelium development GO:0072163 94 0.117
response to organonitrogen compound GO:0010243 246 0.116
Rat
cardiac muscle cell differentiation GO:0055007 69 0.116
nephron tubule formation GO:0072079 20 0.116
regulation of gliogenesis GO:0014013 50 0.115
ventricular trabecula myocardium morphogenesis GO:0003222 11 0.115
regulation of canonical wnt signaling pathway involved in controlling type b pancreatic cell proliferation GO:2000079 1 0.115
hindbrain formation GO:0021576 1 0.115
regulation of transmembrane transport GO:0034762 128 0.114
epithelial cell proliferation GO:0050673 174 0.113
regulation of cellular response to growth factor stimulus GO:0090287 82 0.112
inner ear receptor cell differentiation GO:0060113 61 0.112
striated muscle cell development GO:0055002 125 0.112
proximal distal pattern formation involved in nephron development GO:0072047 5 0.112
renal vesicle morphogenesis GO:0072077 15 0.112
digestive system development GO:0055123 200 0.111
oxygen homeostasis GO:0032364 2 0.111
pituitary gland development GO:0021983 38 0.111
cerebral cortex gabaergic interneuron differentiation GO:0021892 9 0.111
cell maturation GO:0048469 127 0.111
intrahepatic bile duct development GO:0035622 2 0.111
transmission of nerve impulse GO:0019226 76 0.111
Mouse
positive regulation of kidney development GO:0090184 28 0.111
lung cell differentiation GO:0060479 30 0.110
cellular response to carbohydrate stimulus GO:0071322 50 0.110
regulation of kidney development GO:0090183 40 0.110
cell adhesion GO:0007155 329 0.110
regulation of heart growth GO:0060420 31 0.110
acylglycerol metabolic process GO:0006639 55 0.110
carbon catabolite activation of transcription from rna polymerase ii promoter GO:0000436 4 0.109
hypothalamus development GO:0021854 16 0.108
triglyceride metabolic process GO:0006641 51 0.108
oviduct development GO:0060066 3 0.108
wnt signaling pathway GO:0016055 188 0.107
metanephric loop of henle development GO:0072236 4 0.107
digestive tract development GO:0048565 190 0.107
trabecula morphogenesis GO:0061383 40 0.106
organ growth GO:0035265 117 0.106
positive regulation of mechanoreceptor differentiation GO:0045633 1 0.105
striated muscle tissue development GO:0014706 293 0.105
gland development GO:0048732 330 0.104
uterus morphogenesis GO:0061038 2 0.104
collagen fibril organization GO:0030199 32 0.103
bone morphogenesis GO:0060349 78 0.102
planar cell polarity pathway involved in pericardium morphogenesis GO:0061354 2 0.102
regulation of cartilage development GO:0061035 44 0.102
dorsal spinal cord development GO:0021516 20 0.101
calcium ion transport GO:0006816 159 0.101
cardiac muscle cell apoptotic process GO:0010659 10 0.100
response to monosaccharide GO:0034284 67 0.100
cellular response to transforming growth factor beta stimulus GO:0071560 88 0.100
regulation of body fluid levels GO:0050878 162 0.099
tongue development GO:0043586 18 0.098
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.097
positive regulation of neural precursor cell proliferation GO:2000179 42 0.097
auditory receptor cell differentiation GO:0042491 37 0.097
glandular epithelial cell development GO:0002068 15 0.097
Rat
spemann organizer formation at the anterior end of the primitive streak GO:0060064 1 0.096
regulation of cell cycle process GO:0010564 160 0.096
metanephric nephron tubule development GO:0072234 16 0.096
renal vesicle development GO:0072087 17 0.095
embryonic forelimb morphogenesis GO:0035115 32 0.095
specification of nephron tubule identity GO:0072081 5 0.095
regulation of hormone levels GO:0010817 211 0.094
Rat
regulation of embryonic development GO:0045995 71 0.094
mesonephric tubule morphogenesis GO:0072171 63 0.094
skeletal muscle organ development GO:0060538 163 0.094
negative regulation of striated muscle cell apoptotic process GO:0010664 8 0.094
liver development GO:0001889 66 0.094
regulation of organ formation GO:0003156 34 0.094
peripheral nervous system development GO:0007422 53 0.093
neuroepithelial cell differentiation GO:0060563 37 0.093
carbohydrate homeostasis GO:0033500 128 0.093
striated muscle contraction GO:0006941 45 0.092
regulation of muscle cell apoptotic process GO:0010660 17 0.092
renal outer medulla development GO:0072054 2 0.092
cochlea morphogenesis GO:0090103 22 0.092
tube closure GO:0060606 91 0.091
amine metabolic process GO:0009308 45 0.091
planar cell polarity pathway involved in cardiac muscle tissue morphogenesis GO:0061350 2 0.090
neural nucleus development GO:0048857 22 0.090
spemann organizer formation GO:0060061 2 0.090
negative regulation of phosphorylation GO:0042326 166 0.089
regulation of insulin secretion involved in cellular response to glucose stimulus GO:0061178 31 0.089
leydig cell differentiation GO:0033327 10 0.089
gas homeostasis GO:0033483 3 0.089
regulation of mesenchymal cell proliferation GO:0010464 37 0.089
ear development GO:0043583 200 0.088
sarcomere organization GO:0045214 24 0.088
lateral motor column neuron migration GO:0097477 3 0.088
neutral lipid metabolic process GO:0006638 57 0.088
hepaticobiliary system development GO:0061008 67 0.087
cellular response to hexose stimulus GO:0071331 47 0.087
calcium ion transmembrane transport GO:0070588 85 0.087
regulation of endoplasmic reticulum stress induced intrinsic apoptotic signaling pathway GO:1902235 11 0.087
regulation of dna templated transcription initiation GO:2000142 7 0.087
mature b cell differentiation involved in immune response GO:0002313 9 0.087
schwann cell development GO:0014044 22 0.087
positive regulation of cell morphogenesis involved in differentiation GO:0010770 72 0.086
regulation of striated muscle cell apoptotic process GO:0010662 11 0.086
regulation of cardiac muscle contraction GO:0055117 21 0.086
lung epithelial cell differentiation GO:0060487 29 0.086
venous blood vessel development GO:0060841 13 0.086
hair cell differentiation GO:0035315 40 0.085
neuromuscular process GO:0050905 99 0.085
Mouse
regulation of cell cycle GO:0051726 281 0.085
negative regulation of protein metabolic process GO:0051248 282 0.085
neural crest cell development GO:0014032 48 0.083
collagen biosynthetic process GO:0032964 7 0.083
central nervous system morphogenesis GO:0021551 2 0.083
schwann cell differentiation GO:0014037 26 0.083
canonical wnt signaling pathway involved in regulation of cell proliferation GO:0044340 3 0.083
mechanoreceptor differentiation GO:0042490 67 0.083
forelimb morphogenesis GO:0035136 40 0.083
regulation of neuron death GO:1901214 134 0.083
spinal cord association neuron differentiation GO:0021527 14 0.082
mesodermal cell differentiation GO:0048333 22 0.082
multicellular organismal water homeostasis GO:0050891 23 0.082
apoptotic process involved in heart morphogenesis GO:0003278 5 0.082
endomembrane system organization GO:0010256 147 0.082
cerebral cortex neuron differentiation GO:0021895 19 0.081
endoderm development GO:0007492 45 0.081
sclerotome development GO:0061056 4 0.081
hair follicle development GO:0001942 85 0.081
semaphorin plexin signaling pathway involved in outflow tract morphogenesis GO:0071527 1 0.081
t cell activation GO:0042110 289 0.080
establishment of endothelial blood brain barrier GO:0014045 3 0.080
cardiac epithelial to mesenchymal transition GO:0060317 18 0.080
renal water homeostasis GO:0003091 7 0.080
single organism cell adhesion GO:0098602 156 0.079
paramesonephric duct development GO:0061205 3 0.079
regulation of ion transmembrane transporter activity GO:0032412 54 0.079
pallium development GO:0021543 120 0.079
central nervous system neuron development GO:0021954 67 0.079
positive regulation of keratinocyte proliferation GO:0010838 4 0.078
regulation of striated muscle contraction GO:0006942 25 0.078
rhythmic process GO:0048511 174 0.078
divalent metal ion transport GO:0070838 172 0.078
positive regulation of semaphorin plexin signaling pathway involved in outflow tract morphogenesis GO:2000764 1 0.078
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.078
cd4 positive alpha beta t cell differentiation GO:0043367 41 0.078
transcription initiation from rna polymerase ii promoter GO:0006367 8 0.078
cell cycle arrest GO:0007050 37 0.078
noradrenergic neuron differentiation GO:0003357 6 0.078
septum transversum development GO:0003343 2 0.078
forebrain neuron development GO:0021884 30 0.078
negative regulation of protein modification process GO:0031400 163 0.077
regulation of anagen GO:0051884 1 0.077
positive regulation of calcium ion transport GO:0051928 27 0.077
glial cell development GO:0021782 54 0.077
Mouse
positive regulation of mitotic cell cycle GO:0045931 41 0.076
striated muscle cell apoptotic process GO:0010658 12 0.076
regulation of hormone secretion GO:0046883 88 0.076
Rat

Nkx6-1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
osteochondrodysplasia DOID:2256 0 0.088
bone development disease DOID:0080006 0 0.088
bone disease DOID:0080001 0 0.088
disease of anatomical entity DOID:7 0 0.088
musculoskeletal system disease DOID:17 0 0.088
connective tissue disease DOID:65 0 0.088