Mus musculus

168 known processes

Nlgn3

neuroligin 3

(Aliases: NL3,A230085M13Rik,HNL3)

Nlgn3 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
dendrite development GO:0016358 115 0.235
regulation of neuron projection development GO:0010975 169 0.175
alpha amino 3 hydroxy 5 methyl 4 isoxazole propionate selective glutamate receptor clustering GO:0097113 3 0.146
Mouse
synaptic transmission GO:0007268 329 0.133
embryonic organ morphogenesis GO:0048562 276 0.118
regulation of glutamate receptor signaling pathway GO:1900449 16 0.111
axonogenesis GO:0007409 274 0.106
Rat
regulation of cell projection organization GO:0031344 206 0.098
rho protein signal transduction GO:0007266 32 0.091
ion transmembrane transport GO:0034220 361 0.086
glutamate receptor signaling pathway GO:0007215 35 0.085
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.076
inorganic cation transmembrane transport GO:0098662 207 0.076
inorganic ion transmembrane transport GO:0098660 234 0.073
regulation of alpha amino 3 hydroxy 5 methyl 4 isoxazole propionate selective glutamate receptor activity GO:2000311 11 0.071
positive regulation of nervous system development GO:0051962 221 0.064
Mouse Rat
regulation of membrane potential GO:0042391 192 0.064
positive regulation of cell development GO:0010720 237 0.061
chemotaxis GO:0006935 247 0.060
skeletal system development GO:0001501 356 0.058
microtubule based process GO:0007017 236 0.058
negative regulation of cell proliferation GO:0008285 296 0.057
forebrain development GO:0030900 302 0.057
synapse organization GO:0050808 125 0.056
regulation of dendritic spine morphogenesis GO:0061001 17 0.055
protein localization to membrane GO:0072657 108 0.055
Mouse
central nervous system neuron differentiation GO:0021953 162 0.054
regulation of neuron differentiation GO:0045664 281 0.054
response to organonitrogen compound GO:0010243 246 0.054
cell fate commitment GO:0045165 210 0.054
locomotory behavior GO:0007626 195 0.053
Mouse Fly
regionalization GO:0003002 337 0.053
learning GO:0007612 98 0.052
embryonic skeletal system development GO:0048706 120 0.052
transmembrane transport GO:0055085 412 0.052
ras protein signal transduction GO:0007265 77 0.051
cellular amino acid metabolic process GO:0006520 103 0.050
adult behavior GO:0030534 135 0.049
Human Fly
negative regulation of cell development GO:0010721 169 0.049
regulation of cellular amine metabolic process GO:0033238 20 0.048
negative regulation of nervous system development GO:0051961 156 0.048
compound eye development GO:0048749 1 0.048
cognition GO:0050890 149 0.047
membrane depolarization GO:0051899 64 0.047
neuromuscular process GO:0050905 99 0.047
Mouse
camera type eye development GO:0043010 266 0.046
dendritic spine development GO:0060996 30 0.046
negative regulation of cellular component organization GO:0051129 194 0.045
regulation of ion transmembrane transporter activity GO:0032412 54 0.044
regulation of organelle organization GO:0033043 289 0.044
regulation of hydrolase activity GO:0051336 246 0.043
cellular homeostasis GO:0019725 240 0.043
cell adhesion GO:0007155 329 0.042
Mouse Rat
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.041
regulation of cellular amino acid metabolic process GO:0006521 5 0.041
cellular ketone metabolic process GO:0042180 84 0.040
regulation of system process GO:0044057 200 0.039
regulation of cellular ketone metabolic process GO:0010565 66 0.038
lateral inhibition GO:0046331 1 0.038
central nervous system neuron development GO:0021954 67 0.038
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.037
cellular amine metabolic process GO:0044106 44 0.036
regulation of nucleotide metabolic process GO:0006140 169 0.036
developmental maturation GO:0021700 193 0.035
Fly
axon guidance GO:0007411 141 0.034
sensory organ morphogenesis GO:0090596 242 0.033
regulation of excitatory postsynaptic membrane potential GO:0060079 41 0.032
regulation of cellular catabolic process GO:0031329 242 0.032
endocytosis GO:0006897 168 0.031
Mouse Rat
skeletal system morphogenesis GO:0048705 203 0.030
microtubule cytoskeleton organization GO:0000226 157 0.030
neuroblast division in subventricular zone GO:0021849 2 0.030
synapse maturation GO:0060074 14 0.030
Fly
regulation of dendritic spine development GO:0060998 22 0.030
actin cytoskeleton organization GO:0030036 220 0.030
negative regulation of cellular amine metabolic process GO:0033239 1 0.029
protein modification by small protein conjugation GO:0032446 187 0.029
cation transmembrane transport GO:0098655 266 0.029
nitrogen compound transport GO:0071705 271 0.029
regulation of synaptic transmission glutamatergic GO:0051966 19 0.029
neuron neuron synaptic transmission GO:0007270 69 0.029
small gtpase mediated signal transduction GO:0007264 97 0.028
connective tissue development GO:0061448 179 0.028
skin development GO:0043588 220 0.028
cation transport GO:0006812 399 0.028
developmental growth involved in morphogenesis GO:0060560 138 0.028
Rat
intracellular protein transport GO:0006886 204 0.027
single organism cell adhesion GO:0098602 156 0.027
Mouse Rat
gonad development GO:0008406 141 0.027
development of primary sexual characteristics GO:0045137 143 0.026
purine nucleoside triphosphate catabolic process GO:0009146 203 0.026
negative regulation of synapse maturation GO:2000297 2 0.026
gtp metabolic process GO:0046039 144 0.025
mapk cascade GO:0000165 281 0.025
peptidyl amino acid modification GO:0018193 336 0.025
purine ribonucleotide metabolic process GO:0009150 290 0.025
divalent metal ion transport GO:0070838 172 0.025
oxidation reduction process GO:0055114 342 0.025
organelle assembly GO:0070925 177 0.025
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.025
regulation of synaptic plasticity GO:0048167 87 0.025
protein ubiquitination GO:0016567 171 0.025
regulation of purine nucleotide metabolic process GO:1900542 169 0.024
divalent inorganic cation transport GO:0072511 178 0.024
retina development in camera type eye GO:0060041 119 0.024
neuron projection guidance GO:0097485 141 0.024
regulation of transporter activity GO:0032409 57 0.024
canonical wnt signaling pathway GO:0060070 130 0.023
regulation of terminal button organization GO:2000331 1 0.023
cellular response to organonitrogen compound GO:0071417 145 0.023
regulation of rho gtpase activity GO:0032319 58 0.022
regulation of kinase activity GO:0043549 249 0.022
maternal determination of anterior posterior axis embryo GO:0008358 2 0.022
regulation of postsynaptic membrane potential GO:0060078 48 0.022
germ cell development GO:0007281 185 0.022
negative regulation of protein metabolic process GO:0051248 282 0.022
wnt signaling pathway GO:0016055 188 0.022
dorsal ventral axon guidance GO:0033563 3 0.022
regulation of purine nucleotide catabolic process GO:0033121 122 0.022
metencephalon development GO:0022037 89 0.022
protein targeting GO:0006605 143 0.021
learning or memory GO:0007611 148 0.021
sensory perception of mechanical stimulus GO:0050954 107 0.021
sensory perception GO:0007600 245 0.021
Mouse
regulation of organ morphogenesis GO:2000027 144 0.021
positive regulation of organelle organization GO:0010638 128 0.021
leukocyte differentiation GO:0002521 342 0.021
glial cell differentiation GO:0010001 131 0.021
purine ribonucleoside catabolic process GO:0046130 205 0.021
receptor localization to synapse GO:0097120 4 0.021
Mouse
neural tube development GO:0021915 160 0.021
positive regulation of mapk cascade GO:0043410 170 0.021
cerebellum development GO:0021549 77 0.021
gland development GO:0048732 330 0.020
cartilage development GO:0051216 140 0.020
glycosyl compound catabolic process GO:1901658 206 0.020
regulation of cellular response to stress GO:0080135 159 0.020
photoreceptor cell differentiation GO:0046530 52 0.020
nucleobase containing small molecule metabolic process GO:0055086 352 0.020
male gamete generation GO:0048232 285 0.020
positive regulation of protein modification process GO:0031401 299 0.020
sodium ion transmembrane transport GO:0035725 49 0.020
negative regulation of neuron differentiation GO:0045665 101 0.019
regulation of apoptotic signaling pathway GO:2001233 197 0.019
divalent inorganic cation homeostasis GO:0072507 138 0.019
amine metabolic process GO:0009308 45 0.019
spermatid differentiation GO:0048515 115 0.019
regulation of long term synaptic depression GO:1900452 3 0.019
calcium ion transport GO:0006816 159 0.019
positive regulation of neuron projection development GO:0010976 79 0.019
kidney development GO:0001822 213 0.019
stem cell differentiation GO:0048863 268 0.019
morphogenesis of a branching structure GO:0001763 203 0.019
ribonucleoside triphosphate catabolic process GO:0009203 199 0.019
response to organic cyclic compound GO:0014070 198 0.019
negative regulation of phosphorylation GO:0042326 166 0.019
ribose phosphate metabolic process GO:0019693 291 0.019
body fluid secretion GO:0007589 53 0.019
glucose homeostasis GO:0042593 128 0.019
regulation of n methyl d aspartate selective glutamate receptor activity GO:2000310 10 0.019
regulation of cell motility GO:2000145 236 0.019
response to radiation GO:0009314 165 0.019
response to acid chemical GO:0001101 111 0.019
directional locomotion GO:0033058 3 0.019
organic cyclic compound catabolic process GO:1901361 295 0.018
oocyte anterior posterior axis specification GO:0007314 2 0.018
protein modification by small protein conjugation or removal GO:0070647 207 0.018
negative regulation of phosphate metabolic process GO:0045936 184 0.018
negative regulation of cellular protein metabolic process GO:0032269 247 0.018
t cell activation GO:0042110 289 0.018
spermatogenesis GO:0007283 284 0.018
lung development GO:0030324 164 0.018
regulation of proteolysis GO:0030162 164 0.018
positive regulation of membrane potential GO:0045838 15 0.018
ribonucleotide metabolic process GO:0009259 291 0.018
heterocycle catabolic process GO:0046700 280 0.018
appendage morphogenesis GO:0035107 149 0.018
myeloid dendritic cell chemotaxis GO:0002408 2 0.018
lateral line system development GO:0048925 1 0.018
detection of mechanical stimulus involved in sensory perception of pain GO:0050966 4 0.018
peptide secretion GO:0002790 114 0.018
dendritic spine organization GO:0097061 26 0.018
mitotic cell cycle GO:0000278 195 0.018
regulation of nucleotide catabolic process GO:0030811 122 0.018
positive regulation of hydrolase activity GO:0051345 148 0.018
establishment of protein localization to membrane GO:0090150 54 0.017
neuromuscular process controlling balance GO:0050885 59 0.017
Mouse
posttranscriptional regulation of gene expression GO:0010608 155 0.017
regulation of mitotic cell cycle GO:0007346 126 0.017
negative regulation of cell morphogenesis involved in differentiation GO:0010771 48 0.017
regulation of body fluid levels GO:0050878 162 0.017
apoptotic signaling pathway GO:0097190 306 0.017
regulation of cell adhesion GO:0030155 154 0.017
detection of mechanical stimulus GO:0050982 27 0.017
defecation GO:0030421 1 0.017
epithelial tube morphogenesis GO:0060562 303 0.017
regulation of epithelial cell proliferation GO:0050678 141 0.017
telencephalon development GO:0021537 186 0.017
dephosphorylation GO:0016311 129 0.017
positive regulation of cellular amine metabolic process GO:0033240 5 0.017
primary neural tube formation GO:0014020 95 0.017
memory GO:0007613 58 0.017
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.017
positive regulation of cell death GO:0010942 224 0.017
nucleotide metabolic process GO:0009117 332 0.016
ear morphogenesis GO:0042471 118 0.016
regulation of gtp catabolic process GO:0033124 113 0.016
morphogenesis of embryonic epithelium GO:0016331 159 0.016
organophosphate catabolic process GO:0046434 232 0.016
cell division GO:0051301 120 0.016
ribonucleoside catabolic process GO:0042454 206 0.016
protein localization to synapse GO:0035418 11 0.016
Mouse
gtp catabolic process GO:0006184 143 0.016
mitotic cell cycle process GO:1903047 159 0.016
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.016
positive regulation of ras gtpase activity GO:0032320 65 0.016
pole plasm assembly GO:0007315 2 0.016
regulation of cell cycle GO:0051726 281 0.016
cerebral cortex development GO:0021987 86 0.016
bone development GO:0060348 120 0.016
olfactory bulb axon guidance GO:0071678 1 0.016
glycosyl compound metabolic process GO:1901657 246 0.016
nucleoside phosphate catabolic process GO:1901292 222 0.016
ribonucleotide catabolic process GO:0009261 208 0.016
regulation of canonical wnt signaling pathway GO:0060828 82 0.016
response to inorganic substance GO:0010035 96 0.016
mitochondrion organization GO:0007005 134 0.016
ribonucleoside metabolic process GO:0009119 245 0.016
cellular response to hexose stimulus GO:0071331 47 0.015
purine nucleoside catabolic process GO:0006152 205 0.015
regulation of protein complex assembly GO:0043254 83 0.015
cellular response to growth factor stimulus GO:0071363 197 0.015
establishment of organelle localization GO:0051656 122 0.015
Mouse
circadian rhythm GO:0007623 114 0.015
regulation of transferase activity GO:0051338 263 0.015
negative regulation of intracellular signal transduction GO:1902532 167 0.015
lymphocyte differentiation GO:0030098 242 0.015
membrane organization GO:0061024 245 0.015
positive regulation of nucleotide metabolic process GO:0045981 114 0.015
protein maturation GO:0051604 176 0.015
membrane hyperpolarization GO:0060081 21 0.015
carbohydrate homeostasis GO:0033500 128 0.015
asymmetric neuroblast division GO:0055059 1 0.015
positive regulation of neuron projection regeneration GO:0070572 2 0.015
cation homeostasis GO:0055080 212 0.015
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.015
cellular chemical homeostasis GO:0055082 215 0.015
regulation of cellular component biogenesis GO:0044087 181 0.014
Mouse Rat
notch signaling pathway GO:0007219 71 0.014
negative regulation of wnt signaling pathway GO:0030178 73 0.014
oocyte construction GO:0007308 2 0.014
regulation of hormone levels GO:0010817 211 0.014
nucleoside triphosphate metabolic process GO:0009141 230 0.014
establishment or maintenance of cytoskeleton polarity GO:0030952 2 0.014
purine ribonucleotide catabolic process GO:0009154 208 0.014
nucleocytoplasmic transport GO:0006913 139 0.014
negative regulation of molecular function GO:0044092 258 0.014
positive regulation of protein phosphorylation GO:0001934 242 0.014
ear development GO:0043583 200 0.014
cellular response to monosaccharide stimulus GO:0071326 47 0.014
sensory perception of sound GO:0007605 97 0.014
sensory system development GO:0048880 3 0.014
neurotransmitter secretion GO:0007269 62 0.014
Mouse
establishment of synaptic vesicle localization GO:0097480 57 0.014
Mouse
development of primary male sexual characteristics GO:0046546 88 0.014
negative regulation of dendrite development GO:2000171 9 0.014
cellular nitrogen compound catabolic process GO:0044270 280 0.014
anion transport GO:0006820 177 0.014
positive regulation of protein complex assembly GO:0031334 45 0.014
calcium ion transmembrane transport GO:0070588 85 0.014
regulation of nucleoside metabolic process GO:0009118 130 0.014
protein localization to organelle GO:0033365 185 0.014
peptide hormone secretion GO:0030072 109 0.014
regulation of cytoskeleton organization GO:0051493 122 0.013
nuclear division GO:0000280 158 0.013
regulation of secretion by cell GO:1903530 249 0.013
Mouse
nucleotide catabolic process GO:0009166 217 0.013
nucleoside phosphate metabolic process GO:0006753 338 0.013
positive regulation of cellular component biogenesis GO:0044089 94 0.013
Mouse Rat
oocyte axis specification GO:0007309 2 0.013
digestive system development GO:0055123 200 0.013
neuron migration GO:0001764 122 0.013
photoreceptor cell development GO:0042461 40 0.013
embryonic skeletal system morphogenesis GO:0048704 91 0.013
regulation of neurotransmitter levels GO:0001505 87 0.013
Mouse
eye photoreceptor cell differentiation GO:0001754 41 0.013
single organismal cell cell adhesion GO:0016337 131 0.013
Mouse Rat
regulation of mapk cascade GO:0043408 248 0.013
stem cell development GO:0048864 219 0.013
regulation of wnt signaling pathway GO:0030111 123 0.013
regulation of neuronal synaptic plasticity GO:0048168 30 0.013
adult locomotory behavior GO:0008344 91 0.013
Fly
tube formation GO:0035148 140 0.013
regulation of cell migration GO:0030334 219 0.013
positive regulation of gtp catabolic process GO:0033126 85 0.013
regulation of peptide hormone secretion GO:0090276 75 0.013
positive regulation of programmed cell death GO:0043068 218 0.013
negative regulation of inclusion body assembly GO:0090084 1 0.013
cellular ion homeostasis GO:0006873 165 0.013
regulation of protein kinase activity GO:0045859 232 0.013
organonitrogen compound catabolic process GO:1901565 264 0.013
epidermis development GO:0008544 187 0.013
cilium morphogenesis GO:0060271 102 0.013
regulation of extent of cell growth GO:0061387 52 0.013
positive regulation of gtpase activity GO:0043547 85 0.013
actin filament organization GO:0007015 113 0.013
rhythmic process GO:0048511 174 0.013
morphogenesis of a polarized epithelium GO:0001738 37 0.013
body morphogenesis GO:0010171 45 0.012
negative regulation of neuron projection development GO:0010977 50 0.012
spermatid development GO:0007286 108 0.012
formation of organ boundary GO:0010160 1 0.012
purine nucleoside triphosphate metabolic process GO:0009144 226 0.012
nuclear transport GO:0051169 139 0.012
organelle localization GO:0051640 179 0.012
Mouse
protein processing GO:0016485 163 0.012
regulation of ras gtpase activity GO:0032318 88 0.012
organonitrogen compound biosynthetic process GO:1901566 192 0.012
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.012
respiratory tube development GO:0030323 167 0.012
bone morphogenesis GO:0060349 78 0.012
calcium mediated signaling using intracellular calcium source GO:0035584 3 0.012
limb development GO:0060173 166 0.012
regulation of rho protein signal transduction GO:0035023 71 0.012
regulation of cellular response to growth factor stimulus GO:0090287 82 0.012
regulation of establishment of protein localization GO:0070201 181 0.012
receptor mediated endocytosis GO:0006898 51 0.012
Rat
regulation of peptide transport GO:0090087 91 0.012
endomembrane system organization GO:0010256 147 0.012
Fly
purine containing compound metabolic process GO:0072521 311 0.012
macromolecule catabolic process GO:0009057 281 0.012
regulation of protein catabolic process GO:0042176 108 0.012
embryonic epithelial tube formation GO:0001838 130 0.012
synaptic transmission glutamatergic GO:0035249 36 0.012
cellular component assembly involved in morphogenesis GO:0010927 139 0.012
cell substrate adhesion GO:0031589 130 0.012
jnk cascade GO:0007254 72 0.012
neural tube closure GO:0001843 90 0.012
fat cell differentiation GO:0045444 160 0.012
purine nucleoside metabolic process GO:0042278 241 0.012
appendage development GO:0048736 166 0.012
extracellular structure organization GO:0043062 148 0.012
maintenance of location GO:0051235 89 0.012
protein localization to plasma membrane GO:0072659 57 0.012
energy derivation by oxidation of organic compounds GO:0015980 77 0.012
protein catabolic process GO:0030163 221 0.012
female gamete generation GO:0007292 74 0.012
sodium ion transport GO:0006814 73 0.011
multicellular organismal homeostasis GO:0048871 164 0.011
organic anion transport GO:0015711 137 0.011
protein localization to nucleus GO:0034504 121 0.011
nucleoside catabolic process GO:0009164 206 0.011
positive regulation of cellular catabolic process GO:0031331 148 0.011
negative regulation of synaptic transmission glutamatergic GO:0051967 4 0.011
cellular response to lipid GO:0071396 145 0.011
inner ear morphogenesis GO:0042472 101 0.011
epithelial tube formation GO:0072175 130 0.011
small molecule biosynthetic process GO:0044283 132 0.011
dendritic spine morphogenesis GO:0060997 22 0.011
developmental cell growth GO:0048588 84 0.011
Rat
organic acid transport GO:0015849 101 0.011
myeloid cell differentiation GO:0030099 233 0.011
wound healing GO:0042060 157 0.011
organelle fission GO:0048285 170 0.011
establishment or maintenance of microtubule cytoskeleton polarity GO:0030951 1 0.011
actin filament bundle assembly GO:0051017 40 0.011
amide transport GO:0042886 138 0.011
t cell differentiation GO:0030217 174 0.011
keratinocyte development GO:0003334 10 0.011
positive regulation of long term neuronal synaptic plasticity GO:0048170 3 0.011
neuron projection extension GO:1990138 64 0.011
Rat
hindbrain development GO:0030902 128 0.011
regulation of ion transmembrane transport GO:0034765 119 0.011
guanosine containing compound catabolic process GO:1901069 144 0.011
chromatin organization GO:0006325 206 0.010
exploration behavior GO:0035640 21 0.010
Mouse
regulation of endocytosis GO:0030100 69 0.010
Mouse
positive regulation of apoptotic process GO:0043065 217 0.010
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 61 0.010
positive regulation of cell projection organization GO:0031346 95 0.010
ribonucleoside triphosphate metabolic process GO:0009199 220 0.010
tube closure GO:0060606 91 0.010
multicellular organismal signaling GO:0035637 91 0.010
limb morphogenesis GO:0035108 149 0.010
positive regulation of protein kinase activity GO:0045860 144 0.010
intracellular mrna localization GO:0008298 4 0.010
protein import GO:0017038 101 0.010
nucleoside triphosphate catabolic process GO:0009143 205 0.010
mechanoreceptor differentiation GO:0042490 67 0.010
negative regulation of phosphorus metabolic process GO:0010563 184 0.010
regulation of protein localization GO:0032880 231 0.010
regulation of t cell proliferation GO:0042129 92 0.010
b cell activation GO:0042113 161 0.010
extracellular matrix organization GO:0030198 147 0.010
plasma membrane organization GO:0007009 90 0.010
regulation of long term neuronal synaptic plasticity GO:0048169 19 0.010

Nlgn3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.039
nervous system disease DOID:863 0 0.039
central nervous system disease DOID:331 0 0.029
brain disease DOID:936 0 0.016
cancer DOID:162 0 0.016
disease of cellular proliferation DOID:14566 0 0.016
organ system cancer DOID:0050686 0 0.016
sensory system disease DOID:0050155 0 0.015
epilepsy syndrome DOID:1826 0 0.014
electroclinical syndrome DOID:0050701 0 0.014
musculoskeletal system disease DOID:17 0 0.011