Mus musculus

141 known processes

Npc1

Niemann Pick type C1

(Aliases: D18Ertd723e,C85354,lcsd,spm,D18Ertd139e,nmf164,A430089E03Rik)

Npc1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
intracellular cholesterol transport GO:0032367 3 0.999
positive regulation of sterol transport GO:0032373 9 0.999
sterol homeostasis GO:0055092 45 0.999
positive regulation of cholesterol transport GO:0032376 9 0.997
protein lipid complex subunit organization GO:0071825 12 0.995
cholesterol homeostasis GO:0042632 44 0.987
regulation of sterol transport GO:0032371 17 0.986
Fly
phospholipid transfer to membrane GO:0006649 2 0.984
cholesterol transport GO:0030301 38 0.983
intracellular lipid transport GO:0032365 3 0.982
cholesterol efflux GO:0033344 24 0.975
sterol metabolic process GO:0016125 58 0.975
Fly
regulation of plasma lipoprotein particle levels GO:0097006 23 0.968
steroid metabolic process GO:0008202 119 0.966
reverse cholesterol transport GO:0043691 6 0.965
intracellular sterol transport GO:0032366 3 0.965
plasma lipoprotein particle organization GO:0071827 11 0.956
cholesterol metabolic process GO:0008203 56 0.956
positive regulation of cholesterol efflux GO:0010875 9 0.942
sterol transport GO:0015918 38 0.919
organic hydroxy compound transport GO:0015850 93 0.910
lipid transport GO:0006869 98 0.910
lipid homeostasis GO:0055088 63 0.908
regulation of cholesterol transport GO:0032374 17 0.904
Fly
lipid localization GO:0010876 126 0.890
lysosome organization GO:0007040 21 0.859
high density lipoprotein particle assembly GO:0034380 3 0.857
glycerolipid metabolic process GO:0046486 122 0.855
regulation of cellular ketone metabolic process GO:0010565 66 0.828
alcohol metabolic process GO:0006066 116 0.804
Fly
regulation of beta amyloid clearance GO:1900221 1 0.774
positive regulation of lipid transport GO:0032370 22 0.759
positive regulation of reverse cholesterol transport GO:1903064 1 0.751
lipid modification GO:0030258 65 0.743
cellular ketone metabolic process GO:0042180 84 0.743
Fly
positive regulation of beta amyloid clearance GO:1900223 1 0.740
cognition GO:0050890 149 0.728
regulation of insulin receptor signaling pathway GO:0046626 21 0.716
phospholipid transport GO:0015914 21 0.708
energy derivation by oxidation of organic compounds GO:0015980 77 0.699
regulation of phospholipid efflux GO:1902994 2 0.696
regulation of engulfment of apoptotic cell GO:1901074 2 0.668
phospholipid efflux GO:0033700 3 0.663
cdc42 protein signal transduction GO:0032488 0 0.643
purine containing compound metabolic process GO:0072521 311 0.642
regulation of cholesterol efflux GO:0010874 13 0.637
regulation of cellular amino acid metabolic process GO:0006521 5 0.633
phospholipid metabolic process GO:0006644 87 0.631
organophosphate ester transport GO:0015748 28 0.627
glycoprotein biosynthetic process GO:0009101 89 0.625
lipid biosynthetic process GO:0008610 179 0.604
Fly
regulation of planar cell polarity pathway involved in outflow tract morphogenesis GO:2000163 1 0.597
cellular lipid metabolic process GO:0044255 323 0.597
positive regulation of triglyceride metabolic process GO:0090208 9 0.595
negative regulation of planar cell polarity pathway involved in pericardium morphogenesis GO:2000166 1 0.593
regulation of feeding behavior GO:0060259 3 0.583
lytic vacuole organization GO:0080171 21 0.574
oxidation reduction process GO:0055114 342 0.561
negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis GO:2000162 1 0.561
neuron apoptotic process GO:0051402 142 0.558
respiratory system development GO:0060541 190 0.553
regulation of presynaptic membrane organization GO:1901629 3 0.548
anion transport GO:0006820 177 0.541
insulin receptor signaling pathway GO:0008286 49 0.539
organic hydroxy compound metabolic process GO:1901615 203 0.538
beta amyloid clearance GO:0097242 2 0.532
generation of precursor metabolites and energy GO:0006091 103 0.530
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.526
endocytosis GO:0006897 168 0.521
learning or memory GO:0007611 148 0.513
formation of radial glial scaffolds GO:0021943 4 0.505
positive regulation of lipoprotein lipase activity GO:0051006 3 0.502
regulation of cellular catabolic process GO:0031329 242 0.501
regulation of planar cell polarity pathway involved in ventricular septum morphogenesis GO:2000148 1 0.496
cellular amine metabolic process GO:0044106 44 0.491
acylglycerol metabolic process GO:0006639 55 0.487
regulation of planar cell polarity pathway involved in heart morphogenesis GO:2000159 1 0.485
regulation of neuron death GO:1901214 134 0.482
triglyceride metabolic process GO:0006641 51 0.480
neuron death GO:0070997 154 0.474
canonical wnt signaling pathway involved in cardiac neural crest cell differentiation involved in heart development GO:0061310 1 0.469
regulation of cholesterol metabolic process GO:0090181 14 0.467
anatomical structure homeostasis GO:0060249 145 0.459
nucleotide metabolic process GO:0009117 332 0.452
plasma lipoprotein particle remodeling GO:0034369 6 0.452
regulation of lipid storage GO:0010883 20 0.452
positive regulation of lipid metabolic process GO:0045834 40 0.451
regulation of cellular amine metabolic process GO:0033238 20 0.449
neutral lipid metabolic process GO:0006638 57 0.445
organophosphate biosynthetic process GO:0090407 122 0.444
acylglycerol biosynthetic process GO:0046463 18 0.443
water homeostasis GO:0030104 27 0.443
plasma lipoprotein particle clearance GO:0034381 13 0.442
triglyceride homeostasis GO:0070328 15 0.442
plasma lipoprotein particle assembly GO:0034377 6 0.438
gland development GO:0048732 330 0.429
regulation of fatty acid metabolic process GO:0019217 28 0.429
carbohydrate derivative biosynthetic process GO:1901137 183 0.421
ribose phosphate biosynthetic process GO:0046390 59 0.421
regulation of lipid biosynthetic process GO:0046890 54 0.419
amine metabolic process GO:0009308 45 0.419
vacuole organization GO:0007033 38 0.416
regulation of androgen receptor signaling pathway GO:0060765 3 0.406
negative regulation of protein metabolic process GO:0051248 282 0.404
glycerophospholipid metabolic process GO:0006650 71 0.399
ion transmembrane transport GO:0034220 361 0.392
amide transport GO:0042886 138 0.388
regulation of amyloid precursor protein catabolic process GO:1902991 8 0.386
purine containing compound biosynthetic process GO:0072522 70 0.383
sulfur compound biosynthetic process GO:0044272 37 0.383
cellular response to peptide hormone stimulus GO:0071375 92 0.381
regulation of cholesterol biosynthetic process GO:0045540 8 0.378
glycerolipid biosynthetic process GO:0045017 50 0.377
negative regulation of sterol transport GO:0032372 4 0.374
low density lipoprotein particle clearance GO:0034383 8 0.371
cellular amino acid metabolic process GO:0006520 103 0.370
purine nucleotide biosynthetic process GO:0006164 65 0.369
cyclic purine nucleotide metabolic process GO:0052652 43 0.366
negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis GO:2000149 1 0.353
proteoglycan biosynthetic process GO:0030166 20 0.350
negative regulation of platelet derived growth factor receptor beta signaling pathway GO:2000587 2 0.350
positive regulation of insulin receptor signaling pathway GO:0046628 4 0.349
g protein coupled receptor signaling pathway GO:0007186 243 0.348
response to low density lipoprotein particle GO:0055098 2 0.348
response to peptide hormone GO:0043434 127 0.343
positive regulation of lipid biosynthetic process GO:0046889 18 0.335
cyclic nucleotide biosynthetic process GO:0009190 44 0.335
nucleoside phosphate metabolic process GO:0006753 338 0.334
cholesterol storage GO:0010878 4 0.331
regulation of planar cell polarity pathway involved in pericardium morphogenesis GO:2000165 1 0.331
negative regulation of planar cell polarity pathway involved in heart morphogenesis GO:2000160 1 0.330
negative regulation of cellular amide metabolic process GO:0034249 4 0.328
regulation of lipid transport GO:0032368 36 0.326
Fly
negative regulation of cell proliferation GO:0008285 296 0.321
response to nutrient levels GO:0031667 109 0.319
negative regulation of cholesterol transport GO:0032375 4 0.319
positive regulation of fatty acid oxidation GO:0046321 4 0.318
memory GO:0007613 58 0.317
cell proliferation in hindbrain GO:0021534 10 0.315
regulation of endocytosis GO:0030100 69 0.313
organic anion transport GO:0015711 137 0.313
organonitrogen compound biosynthetic process GO:1901566 192 0.312
cholesterol esterification GO:0034435 3 0.310
regulation of phospholipid transport GO:2001138 4 0.308
associative learning GO:0008306 61 0.307
amyloid precursor protein biosynthetic process GO:0042983 3 0.301
glutamine family amino acid metabolic process GO:0009064 15 0.299
engulfment of apoptotic cell GO:0043652 3 0.298
regulation of amyloid precursor protein biosynthetic process GO:0042984 3 0.298
transmembrane transport GO:0055085 412 0.294
negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis GO:2000164 1 0.292
cell type specific apoptotic process GO:0097285 268 0.291
positive regulation of cyclic nucleotide biosynthetic process GO:0030804 24 0.290
lung development GO:0030324 164 0.290
purine nucleotide metabolic process GO:0006163 302 0.288
nitrogen compound transport GO:0071705 271 0.287
acylglycerol homeostasis GO:0055090 16 0.286
regulation of binding GO:0051098 111 0.274
regulation of lipid metabolic process GO:0019216 118 0.273
cerebellum development GO:0021549 77 0.268
ribose phosphate metabolic process GO:0019693 291 0.267
male gamete generation GO:0048232 285 0.267
Fly
negative regulation of cellular protein metabolic process GO:0032269 247 0.266
maintenance of location GO:0051235 89 0.266
wnt signaling pathway GO:0016055 188 0.262
cellular response to peptide GO:1901653 92 0.261
lipoprotein metabolic process GO:0042157 43 0.260
ribonucleotide metabolic process GO:0009259 291 0.259
hindbrain development GO:0030902 128 0.257
connective tissue development GO:0061448 179 0.255
response to starvation GO:0042594 65 0.254
receptor mediated endocytosis of low density lipoprotein particle involved in cholesterol transport GO:0090118 1 0.254
regulation of fatty acid beta oxidation GO:0031998 1 0.252
axis elongation involved in somitogenesis GO:0090245 4 0.252
lipid catabolic process GO:0016042 69 0.251
appendage development GO:0048736 166 0.250
camp biosynthetic process GO:0006171 31 0.246
antral ovarian follicle growth GO:0001547 5 0.245
small molecule biosynthetic process GO:0044283 132 0.243
Fly
regulation of protein maturation GO:1903317 96 0.243
forebrain development GO:0030900 302 0.240
canonical wnt signaling pathway GO:0060070 130 0.239
negative regulation of cell size GO:0045792 3 0.239
cell proliferation involved in outflow tract morphogenesis GO:0061325 4 0.238
germ cell development GO:0007281 185 0.238
Fly
regulation of phospholipase a2 activity GO:0032429 3 0.234
chemical homeostasis within a tissue GO:0048875 9 0.232
macromolecular complex remodeling GO:0034367 6 0.232
synapse organization GO:0050808 125 0.232
regulation of hydrolase activity GO:0051336 246 0.231
regulation of triglyceride metabolic process GO:0090207 17 0.231
synaptic transmission GO:0007268 329 0.230
embryonic viscerocranium morphogenesis GO:0048703 8 0.228
aminoglycan biosynthetic process GO:0006023 15 0.228
dendrite development GO:0016358 115 0.227
stem cell differentiation GO:0048863 268 0.225
osteoblast development GO:0002076 17 0.225
germ line stem cell division GO:0042078 2 0.224
ribonucleoside monophosphate metabolic process GO:0009161 80 0.223
regulation of reverse cholesterol transport GO:1903062 1 0.223
positive regulation of protein ubiquitination involved in ubiquitin dependent protein catabolic process GO:2000060 8 0.221
regulation of mapk cascade GO:0043408 248 0.218
tissue homeostasis GO:0001894 115 0.216
ribonucleotide biosynthetic process GO:0009260 59 0.215
nucleobase containing small molecule metabolic process GO:0055086 352 0.214
defense response to other organism GO:0098542 197 0.214
regulation of defense response GO:0031347 233 0.214
cellular polysaccharide metabolic process GO:0044264 38 0.212
purine ribonucleotide biosynthetic process GO:0009152 59 0.209
skeletal system development GO:0001501 356 0.208
ribonucleoside metabolic process GO:0009119 245 0.208
fat cell differentiation GO:0045444 160 0.208
cholesterol biosynthetic process GO:0006695 15 0.206
sterol transmembrane transport GO:0035382 2 0.206
regulation of fat cell differentiation GO:0045598 81 0.205
energy reserve metabolic process GO:0006112 39 0.204
respiratory tube development GO:0030323 167 0.204
ribonucleoside triphosphate metabolic process GO:0009199 220 0.204
endomembrane system organization GO:0010256 147 0.202
skeletal system morphogenesis GO:0048705 203 0.202
nucleoside phosphate biosynthetic process GO:1901293 79 0.201
bmp signaling pathway GO:0030509 93 0.201
cyclic nucleotide metabolic process GO:0009187 59 0.199
regulation of lipase activity GO:0060191 15 0.199
positive regulation of steroid biosynthetic process GO:0010893 4 0.199
regulation of phosphatidylcholine catabolic process GO:0010899 2 0.199
cellular response to lipopolysaccharide GO:0071222 77 0.199
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.198
nucleoside metabolic process GO:0009116 246 0.197
multicellular organism growth GO:0035264 161 0.195
positive regulation of phospholipid transport GO:2001140 4 0.195
embryonic skeletal system morphogenesis GO:0048704 91 0.193
multicellular organismal homeostasis GO:0048871 164 0.191
protein processing GO:0016485 163 0.188
regulation of steroid biosynthetic process GO:0050810 26 0.187
regulation of cell migration GO:0030334 219 0.185
regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis GO:2000161 1 0.185
cell maturation GO:0048469 127 0.183
positive regulation of phagocytosis engulfment GO:0060100 3 0.183
developmental growth involved in morphogenesis GO:0060560 138 0.182
regulation of transferase activity GO:0051338 263 0.181
regulation of triglyceride biosynthetic process GO:0010866 10 0.181
syncytium formation by plasma membrane fusion GO:0000768 42 0.180
rhythmic process GO:0048511 174 0.179
vesicle organization GO:0016050 60 0.177
spermatogenesis GO:0007283 284 0.176
Fly
response to oxygen levels GO:0070482 62 0.176
kidney development GO:0001822 213 0.175
embryonic appendage morphogenesis GO:0035113 126 0.174
myeloid cell differentiation GO:0030099 233 0.174
sterol esterification GO:0034434 3 0.173
positive regulation of camp metabolic process GO:0030816 19 0.173
positive regulation of triglyceride lipase activity GO:0061365 3 0.173
oocyte maturation GO:0001556 18 0.170
regulation of homeostatic process GO:0032844 182 0.170
positive regulation of presynaptic membrane organization GO:1901631 1 0.170
regulation of translation GO:0006417 71 0.170
negative regulation of defense response GO:0031348 77 0.170
protein lipidation GO:0006497 28 0.169
regulation of cyclic nucleotide metabolic process GO:0030799 40 0.169
embryonic organ morphogenesis GO:0048562 276 0.168
regulation of body fluid levels GO:0050878 162 0.166
positive regulation of transferase activity GO:0051347 167 0.165
camp metabolic process GO:0046058 40 0.165
cellular biogenic amine metabolic process GO:0006576 28 0.165
nucleoside monophosphate metabolic process GO:0009123 85 0.164
embryonic skeletal system development GO:0048706 120 0.163
cellular carbohydrate metabolic process GO:0044262 119 0.163
nucleotide biosynthetic process GO:0009165 78 0.162
response to peptide GO:1901652 136 0.162
neural precursor cell proliferation GO:0061351 121 0.162
midbrain development GO:0030901 35 0.162
glucocorticoid metabolic process GO:0008211 9 0.161
ras protein signal transduction GO:0007265 77 0.160
carbohydrate metabolic process GO:0005975 230 0.159
regulation of protein kinase activity GO:0045859 232 0.159
phospholipid catabolic process GO:0009395 5 0.157
lipoprotein biosynthetic process GO:0042158 33 0.157
skin development GO:0043588 220 0.156
hindbrain radial glia guided cell migration GO:0021932 12 0.154
regulation of organ morphogenesis GO:2000027 144 0.152
cardiac muscle tissue development GO:0048738 130 0.152
steroid esterification GO:0034433 3 0.152
phagocytosis GO:0006909 66 0.151
negative regulation of planar cell polarity pathway involved in neural tube closure GO:2000168 1 0.151
organ growth GO:0035265 117 0.150
branching involved in mammary gland duct morphogenesis GO:0060444 27 0.150
regulation of fatty acid oxidation GO:0046320 10 0.150
cellular response to organonitrogen compound GO:0071417 145 0.150
positive regulation of apoptotic cell clearance GO:2000427 3 0.149
chondroitin sulfate proteoglycan biosynthetic process GO:0050650 8 0.149
regulation of neuron apoptotic process GO:0043523 122 0.149
olfactory learning GO:0008355 2 0.148
metencephalon development GO:0022037 89 0.148
regulation of carbohydrate biosynthetic process GO:0043255 40 0.146
peptide secretion GO:0002790 114 0.146
bone development GO:0060348 120 0.146
schwann cell proliferation GO:0014010 2 0.144
negative regulation of dendrite development GO:2000171 9 0.143
positive regulation of engulfment of apoptotic cell GO:1901076 1 0.143
positive regulation of mapk cascade GO:0043410 170 0.143
carbohydrate derivative catabolic process GO:1901136 231 0.143
epidermis development GO:0008544 187 0.142
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.142
mapk cascade GO:0000165 281 0.142
glucose homeostasis GO:0042593 128 0.141
cellular glucan metabolic process GO:0006073 32 0.141
regulation of activin receptor signaling pathway GO:0032925 10 0.141
negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis GO:2000151 1 0.140
long term memory GO:0007616 15 0.140
regulation of platelet derived growth factor receptor beta signaling pathway GO:2000586 2 0.139
positive regulation of lipid storage GO:0010884 10 0.138
small molecule catabolic process GO:0044282 71 0.138
positive regulation of programmed cell death GO:0043068 218 0.138
positive regulation of carbohydrate metabolic process GO:0045913 30 0.138
regulation of synaptic plasticity GO:0048167 87 0.138
extrinsic apoptotic signaling pathway GO:0097191 126 0.138
urogenital system development GO:0001655 261 0.137
glycosyl compound catabolic process GO:1901658 206 0.136
glycoprotein metabolic process GO:0009100 116 0.136
negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 26 0.135
regulation of planar cell polarity pathway involved in neural tube closure GO:2000167 1 0.135
regulation of vesicle mediated transport GO:0060627 139 0.134
secretory granule organization GO:0033363 20 0.133
branching morphogenesis of an epithelial tube GO:0048754 159 0.133
cellular response to biotic stimulus GO:0071216 92 0.133
glycosyl compound metabolic process GO:1901657 246 0.131
sterol biosynthetic process GO:0016126 17 0.131
polysaccharide metabolic process GO:0005976 39 0.131
positive regulation of gene silencing by mirna GO:2000637 1 0.130
negative regulation of glycoprotein metabolic process GO:1903019 3 0.130
canonical wnt signaling pathway involved in regulation of cell proliferation GO:0044340 3 0.129
regulation of wnt signaling pathway GO:0030111 123 0.128
regulation of systemic arterial blood pressure GO:0003073 61 0.128
nucleoside triphosphate metabolic process GO:0009141 230 0.128
response to extracellular stimulus GO:0009991 127 0.128
positive regulation of kinase activity GO:0033674 155 0.127
protein localization to nucleus GO:0034504 121 0.127
regulation of organelle organization GO:0033043 289 0.126
positive regulation of fatty acid beta oxidation GO:0032000 1 0.126
purine ribonucleotide metabolic process GO:0009150 290 0.126
segmentation GO:0035282 93 0.125
protein kinase b signaling GO:0043491 74 0.125
regulation of lymphocyte activation GO:0051249 240 0.125
response to organic cyclic compound GO:0014070 198 0.124
negative regulation of inflammatory response GO:0050728 61 0.123
regulation of cholesterol esterification GO:0010872 2 0.122
regulation of membrane potential GO:0042391 192 0.122
gene silencing by mirna GO:0035195 10 0.120
triglyceride biosynthetic process GO:0019432 17 0.120
mitochondrion organization GO:0007005 134 0.120
response to cholesterol GO:0070723 4 0.120
cellular response to starvation GO:0009267 57 0.120
positive regulation of fatty acid metabolic process GO:0045923 8 0.118
alcohol biosynthetic process GO:0046165 43 0.118
response to decreased oxygen levels GO:0036293 59 0.118
negative regulation of lipid storage GO:0010888 6 0.118
negative regulation of cellular amine metabolic process GO:0033239 1 0.117
purine nucleoside monophosphate metabolic process GO:0009126 81 0.117
macroautophagy GO:0016236 21 0.117
cellular response to insulin stimulus GO:0032869 78 0.117
negative regulation of phosphorus metabolic process GO:0010563 184 0.116
regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis GO:2000150 1 0.115
negative regulation of cellular component organization GO:0051129 194 0.115
protein modification by small protein conjugation or removal GO:0070647 207 0.115
regulation of cellular response to stress GO:0080135 159 0.115
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.115
non canonical wnt signaling pathway GO:0035567 33 0.115
cardiocyte differentiation GO:0035051 87 0.114
regulation of camp biosynthetic process GO:0030817 25 0.112
autophagy GO:0006914 45 0.112
regulation of cellular component biogenesis GO:0044087 181 0.109
positive regulation of fatty acid biosynthetic process GO:0045723 3 0.109
diencephalon development GO:0021536 63 0.107
ovulation cycle GO:0042698 59 0.107
feeding behavior GO:0007631 62 0.107
adult behavior GO:0030534 135 0.107
cellular nitrogen compound catabolic process GO:0044270 280 0.106
translation GO:0006412 93 0.106
negative regulation of neuron death GO:1901215 98 0.104
positive regulation of phospholipid efflux GO:1902995 2 0.104
regulation of nucleotide biosynthetic process GO:0030808 34 0.104
membrane organization GO:0061024 245 0.103
Human
pole plasm assembly GO:0007315 2 0.103
membrane depolarization GO:0051899 64 0.102
regulation of receptor activity GO:0010469 41 0.102
posttranscriptional regulation of gene expression GO:0010608 155 0.102
regulation of blood pressure GO:0008217 93 0.102
negative regulation of lipid transport GO:0032369 8 0.102
amyloid precursor protein catabolic process GO:0042987 10 0.101
negative regulation of apoptotic signaling pathway GO:2001234 104 0.100
plasma membrane long chain fatty acid transport GO:0015911 1 0.100
locomotory behavior GO:0007626 195 0.100
muscle tissue development GO:0060537 308 0.100
phospholipid homeostasis GO:0055091 6 0.100
positive regulation of protein phosphorylation GO:0001934 242 0.099
wnt signaling pathway involved in somitogenesis GO:0090244 4 0.099
cellular protein catabolic process GO:0044257 155 0.099
multicellular organismal response to stress GO:0033555 62 0.099
cytoplasmic transport GO:0016482 234 0.098
high density lipoprotein particle remodeling GO:0034375 4 0.098
negative regulation of beta amyloid formation GO:1902430 4 0.098
positive regulation of cell death GO:0010942 224 0.098
regulation of cellular ketone metabolic process by regulation of transcription from rna polymerase ii promoter GO:0072364 7 0.098
retina homeostasis GO:0001895 23 0.098
lipoprotein catabolic process GO:0042159 7 0.098
purine ribonucleoside metabolic process GO:0046128 241 0.097
wnt signaling pathway involved in forebrain neuroblast division GO:0021874 2 0.097
carboxylic acid transport GO:0046942 100 0.097
cell proliferation in external granule layer GO:0021924 10 0.096
epithelial cell proliferation GO:0050673 174 0.096
digestive tract morphogenesis GO:0048546 147 0.096
regulation of cholesterol homeostasis GO:2000188 9 0.095
regulation of phagocytosis engulfment GO:0060099 5 0.095
synapse assembly GO:0007416 56 0.094
positive regulation of protein localization to cell surface GO:2000010 2 0.093
adaptive immune response GO:0002250 155 0.092
regulation of purine nucleotide metabolic process GO:1900542 169 0.092
regulation of protein processing GO:0070613 96 0.092
response to organonitrogen compound GO:0010243 246 0.091
amyloid precursor protein metabolic process GO:0042982 13 0.091
renal system development GO:0072001 225 0.090
canonical wnt signaling pathway involved in neural crest cell differentiation GO:0044335 1 0.090
regulation of adaptive immune response GO:0002819 90 0.089
epithelial tube morphogenesis GO:0060562 303 0.089
glycosaminoglycan biosynthetic process GO:0006024 15 0.089
visual perception GO:0007601 52 0.089
regulation of protein serine threonine kinase activity GO:0071900 157 0.089
nucleoside phosphate catabolic process GO:1901292 222 0.089
intestinal absorption GO:0050892 13 0.088
apoptotic cell clearance GO:0043277 17 0.088
cardiac chamber development GO:0003205 108 0.088
lipid storage GO:0019915 36 0.088
glucan metabolic process GO:0044042 32 0.088
planar cell polarity pathway involved in outflow tract morphogenesis GO:0061347 2 0.088
glycogen metabolic process GO:0005977 32 0.087
protein modification by small protein conjugation GO:0032446 187 0.087
negative regulation of cholesterol efflux GO:0090370 4 0.087
regulation of system process GO:0044057 200 0.087
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.087
apoptotic signaling pathway GO:0097190 306 0.087
regulation of lymphocyte proliferation GO:0050670 117 0.086
transforming growth factor beta receptor signaling pathway GO:0007179 71 0.086
stem cell maintenance GO:0019827 130 0.085
regulation of protein localization GO:0032880 231 0.085
external genitalia morphogenesis GO:0035261 1 0.085
peptide metabolic process GO:0006518 46 0.085
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 61 0.085
appendage morphogenesis GO:0035107 149 0.084
positive regulation of lymphocyte activation GO:0051251 140 0.084
microtubule based process GO:0007017 236 0.083
negative regulation of fat cell differentiation GO:0045599 36 0.083
oocyte development GO:0048599 33 0.083
erbb signaling pathway GO:0038127 32 0.083
response to insulin GO:0032868 100 0.083
female gamete generation GO:0007292 74 0.083
cellular response to molecule of bacterial origin GO:0071219 83 0.082
negative regulation of amyloid precursor protein biosynthetic process GO:0042985 2 0.082
negative regulation of protein processing GO:0010955 79 0.081
response to lipopolysaccharide GO:0032496 128 0.081
ribonucleoside triphosphate catabolic process GO:0009203 199 0.081
immune response regulating signaling pathway GO:0002764 125 0.080
regulation of leukocyte proliferation GO:0070663 121 0.080
locomotor rhythm GO:0045475 8 0.080
regulation of mesenchymal cell proliferation GO:0010464 37 0.080
regulation of fatty acid biosynthetic process GO:0042304 12 0.080
cation homeostasis GO:0055080 212 0.080
regulation of ion transport GO:0043269 215 0.080
positive regulation of glucose metabolic process GO:0010907 21 0.080
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.079
developmental maturation GO:0021700 193 0.079
negative regulation of protein maturation GO:1903318 79 0.079
canonical wnt signaling pathway involved in heart development GO:0061316 3 0.079
positive regulation of endocytosis GO:0045807 42 0.079
cholesterol import GO:0070508 2 0.079
telencephalon development GO:0021537 186 0.079
photoreceptor cell maintenance GO:0045494 19 0.078
positive regulation of ossification GO:0045778 47 0.078
peptidyl lysine modification GO:0018205 77 0.078
regulation of anion transport GO:0044070 27 0.078
canonical wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation GO:0061324 2 0.078
protein targeting GO:0006605 143 0.078
ventricular system development GO:0021591 27 0.078
fatty acid transmembrane transport GO:1902001 1 0.078
regulation of neuron differentiation GO:0045664 281 0.077
nucleoside monophosphate catabolic process GO:0009125 59 0.077
lung alveolus development GO:0048286 45 0.077
learning GO:0007612 98 0.077
organic acid transport GO:0015849 101 0.077

Npc1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.991
Human
lipid metabolism disorder DOID:3146 0 0.934
inherited metabolic disorder DOID:655 0 0.934
Human
central nervous system disease DOID:331 0 0.184
disease of anatomical entity DOID:7 0 0.184
Human
nervous system disease DOID:863 0 0.184
immune system disease DOID:2914 0 0.176
Human
lymphatic system disease DOID:75 0 0.176
Human
acquired metabolic disease DOID:0060158 0 0.107
neurodegenerative disease DOID:1289 0 0.078