Mus musculus

36 known processes

P4htm

prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)

(Aliases: AI853847,MGC130597,4933406E20Rik,Ph-4,BB128974)

P4htm biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
hypoxia inducible factor 1alpha signaling pathway GO:0097411 2 0.349
gas homeostasis GO:0033483 3 0.124
cellular amino acid metabolic process GO:0006520 103 0.119
oxygen homeostasis GO:0032364 2 0.104
mitochondrion organization GO:0007005 134 0.073
carbohydrate derivative catabolic process GO:1901136 231 0.070
4 hydroxyproline metabolic process GO:0019471 5 0.068
microtubule based movement GO:0007018 84 0.067
microtubule based process GO:0007017 236 0.061
purine nucleotide metabolic process GO:0006163 302 0.061
peptidyl amino acid modification GO:0018193 336 0.060
response to oxidative stress GO:0006979 123 0.057
camera type eye development GO:0043010 266 0.057
cellular response to dna damage stimulus GO:0006974 207 0.053
ribonucleotide metabolic process GO:0009259 291 0.052
primary neural tube formation GO:0014020 95 0.052
regulation of cellular amino acid metabolic process GO:0006521 5 0.049
connective tissue replacement involved in inflammatory response wound healing GO:0002248 3 0.049
regulation of nucleotide metabolic process GO:0006140 169 0.046
heterocycle catabolic process GO:0046700 280 0.045
regulation of cell cycle GO:0051726 281 0.044
negative regulation of purine nucleotide catabolic process GO:0033122 9 0.044
inflammatory response to wounding GO:0090594 4 0.044
regulation of cellular ketone metabolic process GO:0010565 66 0.043
transition metal ion homeostasis GO:0055076 54 0.043
cardiac chamber development GO:0003205 108 0.042
muscle tissue development GO:0060537 308 0.042
cell type specific apoptotic process GO:0097285 268 0.042
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.041
intracellular protein transport GO:0006886 204 0.041
purine ribonucleotide metabolic process GO:0009150 290 0.041
regulation of membrane potential GO:0042391 192 0.040
angiogenesis GO:0001525 201 0.040
cytoplasmic transport GO:0016482 234 0.039
cellular modified amino acid metabolic process GO:0006575 63 0.039
neuron apoptotic process GO:0051402 142 0.039
ribose phosphate metabolic process GO:0019693 291 0.037
extracellular structure organization GO:0043062 148 0.037
amine metabolic process GO:0009308 45 0.037
cell growth GO:0016049 130 0.036
negative regulation of t cell apoptotic process GO:0070233 18 0.036
glycolytic process GO:0006096 20 0.035
organonitrogen compound catabolic process GO:1901565 264 0.035
microtubule based transport GO:0010970 50 0.034
negative regulation of lymphocyte apoptotic process GO:0070229 24 0.034
wound healing involved in inflammatory response GO:0002246 4 0.034
organic hydroxy compound metabolic process GO:1901615 203 0.034
transmembrane transport GO:0055085 412 0.033
apoptotic signaling pathway GO:0097190 306 0.033
nitrogen compound transport GO:0071705 271 0.033
cation transport GO:0006812 399 0.033
chemotaxis GO:0006935 247 0.033
regulation of cellular response to hypoxia GO:1900037 2 0.032
purine ribonucleotide catabolic process GO:0009154 208 0.032
skeletal system development GO:0001501 356 0.031
regulation of cell growth GO:0001558 91 0.031
purine containing compound catabolic process GO:0072523 213 0.031
tube formation GO:0035148 140 0.031
protein export from nucleus GO:0006611 20 0.031
nucleotide catabolic process GO:0009166 217 0.031
blood vessel morphogenesis GO:0048514 285 0.031
columnar cuboidal epithelial cell maturation GO:0002069 4 0.031
protein hydroxylation GO:0018126 4 0.030
regulation of neuron apoptotic process GO:0043523 122 0.030
thymocyte apoptotic process GO:0070242 19 0.030
neural precursor cell proliferation GO:0061351 121 0.030
nucleoside phosphate metabolic process GO:0006753 338 0.030
aromatic compound catabolic process GO:0019439 286 0.029
cellular response to organonitrogen compound GO:0071417 145 0.029
muscle cell differentiation GO:0042692 261 0.029
regulation of hydrolase activity GO:0051336 246 0.029
regulation of secretion by cell GO:1903530 249 0.029
regulation of cellular component biogenesis GO:0044087 181 0.028
embryonic epithelial tube formation GO:0001838 130 0.028
macromolecule catabolic process GO:0009057 281 0.028
negative regulation of phosphorus metabolic process GO:0010563 184 0.027
negative regulation of purine nucleotide metabolic process GO:1900543 16 0.027
regulation of cellular catabolic process GO:0031329 242 0.027
protein catabolic process GO:0030163 221 0.027
nuclear export GO:0051168 34 0.027
regulation of cyclic nucleotide metabolic process GO:0030799 40 0.027
cellular response to hormone stimulus GO:0032870 150 0.027
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.027
respiratory system development GO:0060541 190 0.026
epithelial cell differentiation involved in mammary gland alveolus development GO:0061030 4 0.026
cellular response to oxidative stress GO:0034599 76 0.026
visual perception GO:0007601 52 0.026
sensory perception of light stimulus GO:0050953 54 0.026
myeloid cell homeostasis GO:0002262 114 0.026
positive regulation of apoptotic process GO:0043065 217 0.025
response to nitric oxide GO:0071731 4 0.025
regulation of cellular amine metabolic process GO:0033238 20 0.025
forebrain development GO:0030900 302 0.025
positive regulation of cell development GO:0010720 237 0.025
axon transport of mitochondrion GO:0019896 2 0.025
organic cyclic compound catabolic process GO:1901361 295 0.025
protein localization to organelle GO:0033365 185 0.025
nucleotide metabolic process GO:0009117 332 0.025
locomotory behavior GO:0007626 195 0.024
regulation of organelle organization GO:0033043 289 0.024
monocarboxylic acid metabolic process GO:0032787 191 0.024
germ cell development GO:0007281 185 0.024
pyruvate metabolic process GO:0006090 28 0.024
regulation of kinase activity GO:0043549 249 0.024
striated muscle tissue development GO:0014706 293 0.024
sensory perception GO:0007600 245 0.023
protein complex disassembly GO:0043241 40 0.023
negative regulation of cellular component organization GO:0051129 194 0.023
response to reactive oxygen species GO:0000302 56 0.023
extracellular matrix organization GO:0030198 147 0.023
homeostasis of number of cells GO:0048872 210 0.023
cellular response to insulin stimulus GO:0032869 78 0.023
negative regulation of hydrolase activity GO:0051346 71 0.023
negative regulation of phosphate metabolic process GO:0045936 184 0.023
microtubule cytoskeleton organization GO:0000226 157 0.023
autophagy GO:0006914 45 0.023
inorganic ion transmembrane transport GO:0098660 234 0.023
positive regulation of protein modification process GO:0031401 299 0.023
retina development in camera type eye GO:0060041 119 0.023
negative regulation of cellular protein metabolic process GO:0032269 247 0.022
cyclic nucleotide metabolic process GO:0009187 59 0.022
regulation of vasculature development GO:1901342 88 0.022
regulation of secretion GO:0051046 274 0.022
negative regulation of growth GO:0045926 99 0.022
negative regulation of nucleotide catabolic process GO:0030812 9 0.022
glucose homeostasis GO:0042593 128 0.022
glycoprotein metabolic process GO:0009100 116 0.022
negative regulation of cellular amine metabolic process GO:0033239 1 0.022
cellular response to peptide GO:1901653 92 0.022
epithelial cell development GO:0002064 159 0.022
peptidyl proline hydroxylation to 4 hydroxy l proline GO:0018401 2 0.022
carbohydrate catabolic process GO:0016052 32 0.022
inflammatory response GO:0006954 244 0.022
organelle fission GO:0048285 170 0.022
b 1 b cell homeostasis GO:0001922 4 0.022
cell adhesion GO:0007155 329 0.021
cellular ketone metabolic process GO:0042180 84 0.021
protein modification by small protein conjugation GO:0032446 187 0.021
protein modification by small protein conjugation or removal GO:0070647 207 0.021
regulation of protein localization GO:0032880 231 0.021
cardiac septum development GO:0003279 59 0.021
regulation of autophagy GO:0010506 30 0.021
positive regulation of programmed cell death GO:0043068 218 0.021
b cell homeostasis GO:0001782 34 0.021
hormone secretion GO:0046879 128 0.021
lymphocyte homeostasis GO:0002260 64 0.021
neural tube development GO:0021915 160 0.021
negative regulation of molecular function GO:0044092 258 0.020
epithelial tube formation GO:0072175 130 0.020
telencephalon development GO:0021537 186 0.020
cellular carbohydrate metabolic process GO:0044262 119 0.020
purine nucleotide catabolic process GO:0006195 211 0.020
negative regulation of oxidative stress induced intrinsic apoptotic signaling pathway GO:1902176 4 0.020
macromolecular complex disassembly GO:0032984 43 0.020
positive regulation of secretion GO:0051047 130 0.020
neuron death GO:0070997 154 0.020
dna metabolic process GO:0006259 303 0.020
cellular homeostasis GO:0019725 240 0.020
alpha amino acid metabolic process GO:1901605 59 0.020
cognition GO:0050890 149 0.020
mitotic cell cycle GO:0000278 195 0.020
oxidation reduction process GO:0055114 342 0.020
regulation of angiogenesis GO:0045765 81 0.019
connective tissue development GO:0061448 179 0.019
negative regulation of intracellular signal transduction GO:1902532 167 0.019
multicellular organismal homeostasis GO:0048871 164 0.019
neural tube formation GO:0001841 108 0.019
neuronal action potential GO:0019228 54 0.019
nucleobase containing small molecule metabolic process GO:0055086 352 0.019
negative regulation of organelle organization GO:0010639 90 0.019
cellular macromolecule catabolic process GO:0044265 206 0.019
response to oxygen levels GO:0070482 62 0.019
embryonic placenta development GO:0001892 98 0.018
ribonucleotide catabolic process GO:0009261 208 0.018
ion transmembrane transport GO:0034220 361 0.018
mitotic cell cycle process GO:1903047 159 0.018
cellular response to peptide hormone stimulus GO:0071375 92 0.018
peptide transport GO:0015833 133 0.018
trachea development GO:0060438 18 0.018
establishment of organelle localization GO:0051656 122 0.018
placenta development GO:0001890 140 0.018
cytokine production GO:0001816 319 0.018
response to extracellular stimulus GO:0009991 127 0.018
nucleoside phosphate catabolic process GO:1901292 222 0.018
cellular nitrogen compound catabolic process GO:0044270 280 0.018
regulation of microtubule based process GO:0032886 52 0.018
reactive oxygen species metabolic process GO:0072593 84 0.018
response to insulin GO:0032868 100 0.018
labyrinthine layer development GO:0060711 49 0.018
pallium development GO:0021543 120 0.018
glycosyl compound catabolic process GO:1901658 206 0.017
response to inorganic substance GO:0010035 96 0.017
regulation of cytoskeleton organization GO:0051493 122 0.017
cellular response to lipopolysaccharide GO:0071222 77 0.017
ubiquitin dependent protein catabolic process GO:0006511 129 0.017
cellular metal ion homeostasis GO:0006875 151 0.017
organelle localization GO:0051640 179 0.017
regulation of ion transport GO:0043269 215 0.017
response to decreased oxygen levels GO:0036293 59 0.017
organelle assembly GO:0070925 177 0.017
synaptic transmission GO:0007268 329 0.017
negative regulation of cell proliferation GO:0008285 296 0.017
purine containing compound metabolic process GO:0072521 311 0.017
response to light stimulus GO:0009416 135 0.017
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.017
regulation of transcription from rna polymerase ii promoter in response to stress GO:0043618 8 0.017
cardiac chamber morphogenesis GO:0003206 93 0.017
camp catabolic process GO:0006198 4 0.017
developmental maturation GO:0021700 193 0.017
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 40 0.017
positive regulation of autophagy GO:0010508 9 0.016
axon cargo transport GO:0008088 33 0.016
response to peptide hormone GO:0043434 127 0.016
blood circulation GO:0008015 195 0.016
cellular response to glucose stimulus GO:0071333 45 0.016
learning or memory GO:0007611 148 0.016
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.016
regulation of lymphocyte apoptotic process GO:0070228 41 0.016
phenol containing compound metabolic process GO:0018958 60 0.016
engulfment of apoptotic cell GO:0043652 3 0.016
response to radiation GO:0009314 165 0.016
nucleocytoplasmic transport GO:0006913 139 0.016
circulatory system process GO:0003013 197 0.016
regulation of neuron death GO:1901214 134 0.016
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.016
protein ubiquitination GO:0016567 171 0.016
carbohydrate homeostasis GO:0033500 128 0.016
tissue homeostasis GO:0001894 115 0.016
learning GO:0007612 98 0.016
posttranscriptional regulation of gene expression GO:0010608 155 0.016
determination of left right symmetry GO:0007368 80 0.016
regulation of protein kinase activity GO:0045859 232 0.016
cellular response to nutrient levels GO:0031669 64 0.016
cellular response to growth factor stimulus GO:0071363 197 0.016
regulation of homeostatic process GO:0032844 182 0.015
multicellular organismal signaling GO:0035637 91 0.015
response to nutrient levels GO:0031667 109 0.015
heart process GO:0003015 94 0.015
morphogenesis of embryonic epithelium GO:0016331 159 0.015
rho protein signal transduction GO:0007266 32 0.015
positive regulation of nervous system development GO:0051962 221 0.015
iron ion homeostasis GO:0055072 36 0.015
urogenital system development GO:0001655 261 0.015
nuclear division GO:0000280 158 0.015
t cell apoptotic process GO:0070231 39 0.015
regulation of t cell apoptotic process GO:0070232 28 0.015
nuclear transport GO:0051169 139 0.015
cellular ion homeostasis GO:0006873 165 0.015
regulation of leukocyte apoptotic process GO:2000106 56 0.015
positive regulation of nucleotide metabolic process GO:0045981 114 0.015
modification dependent protein catabolic process GO:0019941 133 0.015
fat cell differentiation GO:0045444 160 0.015
regulation of body fluid levels GO:0050878 162 0.015
cellular iron ion homeostasis GO:0006879 16 0.014
negative regulation of protein complex disassembly GO:0043242 22 0.014
heart contraction GO:0060047 93 0.014
fertilization GO:0009566 127 0.014
cellular amine metabolic process GO:0044106 44 0.014
purine ribonucleoside catabolic process GO:0046130 205 0.014
spindle assembly involved in mitosis GO:0090307 4 0.014
regulation of anatomical structure size GO:0090066 178 0.014
regulation of cell size GO:0008361 72 0.014
regulation of tor signaling GO:0032006 17 0.014
regulation of hormone levels GO:0010817 211 0.014
regulation of cell projection organization GO:0031344 206 0.014
positive regulation of cellular amine metabolic process GO:0033240 5 0.014
positive regulation of insulin secretion involved in cellular response to glucose stimulus GO:0035774 13 0.014
t cell activation GO:0042110 289 0.014
regulation of microtubule depolymerization GO:0031114 13 0.014
regulation of peptide transport GO:0090087 91 0.014
hematopoietic progenitor cell differentiation GO:0002244 143 0.014
spermatogenesis GO:0007283 284 0.014
regulation of intrinsic apoptotic signaling pathway GO:2001242 61 0.014
peptide secretion GO:0002790 114 0.014
microtubule polymerization or depolymerization GO:0031109 26 0.014
cation homeostasis GO:0055080 212 0.014
negative regulation of protein metabolic process GO:0051248 282 0.014
regulation of cellular response to stress GO:0080135 159 0.014
regulation of myeloid cell differentiation GO:0045637 96 0.014
cellular chemical homeostasis GO:0055082 215 0.014
regulation of neuron differentiation GO:0045664 281 0.014
heart trabecula formation GO:0060347 14 0.014
regulation of purine nucleotide metabolic process GO:1900542 169 0.014
regulation of system process GO:0044057 200 0.013
regulation of protein depolymerization GO:1901879 26 0.013
cardiac muscle cell contraction GO:0086003 7 0.013
neural fold elevation formation GO:0021502 1 0.013
regulation of peptide hormone secretion GO:0090276 75 0.013
regulation of neuron projection development GO:0010975 169 0.013
negative regulation of thymocyte apoptotic process GO:0070244 8 0.013
smoothened signaling pathway GO:0007224 105 0.013
peptide hormone secretion GO:0030072 109 0.013
response to monosaccharide GO:0034284 67 0.013
protein depolymerization GO:0051261 34 0.013
regulation of apoptotic signaling pathway GO:2001233 197 0.013
myeloid cell differentiation GO:0030099 233 0.013
generation of precursor metabolites and energy GO:0006091 103 0.013
carbohydrate metabolic process GO:0005975 230 0.013
dendrite development GO:0016358 115 0.013
modification dependent macromolecule catabolic process GO:0043632 133 0.013
response to acid chemical GO:0001101 111 0.013
gliogenesis GO:0042063 141 0.013
cellular response to molecule of bacterial origin GO:0071219 83 0.013
peptidyl proline modification GO:0018208 6 0.013
leukocyte homeostasis GO:0001776 79 0.013
embryonic organ morphogenesis GO:0048562 276 0.013
positive regulation of secretion by cell GO:1903532 114 0.013
muscle cell cellular homeostasis GO:0046716 12 0.013
amide transport GO:0042886 138 0.013
developmental growth involved in morphogenesis GO:0060560 138 0.013
renal system development GO:0072001 225 0.012
regulation of hormone secretion GO:0046883 88 0.012
negative regulation of microtubule polymerization or depolymerization GO:0031111 15 0.012
cellular component assembly involved in morphogenesis GO:0010927 139 0.012
cellular response to decreased oxygen levels GO:0036294 18 0.012
regulation of protein catabolic process GO:0042176 108 0.012
regulation of thymocyte apoptotic process GO:0070243 14 0.012
cation transmembrane transport GO:0098655 266 0.012
insulin secretion involved in cellular response to glucose stimulus GO:0035773 36 0.012
divalent inorganic cation transport GO:0072511 178 0.012
cardiac ventricle development GO:0003231 83 0.012
chromatin modification GO:0016568 187 0.012
response to growth factor GO:0070848 198 0.012
microtubule depolymerization GO:0007019 15 0.012
ribonucleoside metabolic process GO:0009119 245 0.012
ribonucleoside monophosphate metabolic process GO:0009161 80 0.012
small gtpase mediated signal transduction GO:0007264 97 0.012
actin cytoskeleton organization GO:0030036 220 0.012
action potential GO:0001508 78 0.012
cellular response to acid chemical GO:0071229 68 0.012
regulation of cell migration GO:0030334 219 0.012
oocyte axis specification GO:0007309 2 0.012
purine nucleoside metabolic process GO:0042278 241 0.012
protein maturation GO:0051604 176 0.012
cell maturation GO:0048469 127 0.012
female gamete generation GO:0007292 74 0.012
asymmetric neuroblast division GO:0055059 1 0.012
intraciliary retrograde transport GO:0035721 3 0.012
positive regulation of cell growth GO:0030307 33 0.012
cellular response to extracellular stimulus GO:0031668 81 0.012
cellular protein complex disassembly GO:0043624 36 0.011
positive regulation of peptide secretion GO:0002793 33 0.011
regulation of cell motility GO:2000145 236 0.011
protein localization to membrane GO:0072657 108 0.011
cellular response to external stimulus GO:0071496 88 0.011
response to organonitrogen compound GO:0010243 246 0.011
cellular response to hexose stimulus GO:0071331 47 0.011
heart morphogenesis GO:0003007 178 0.011
purine nucleoside triphosphate catabolic process GO:0009146 203 0.011
neuron projection guidance GO:0097485 141 0.011
regulation of proteolysis GO:0030162 164 0.011
regulation of protein complex disassembly GO:0043244 28 0.011
purine nucleoside catabolic process GO:0006152 205 0.011
ventricular septum development GO:0003281 42 0.011
organonitrogen compound biosynthetic process GO:1901566 192 0.011
regulation of cell cycle process GO:0010564 160 0.011
negative regulation of cellular catabolic process GO:0031330 47 0.011
response to hypoxia GO:0001666 58 0.011
actin filament organization GO:0007015 113 0.011
positive regulation of peptide hormone secretion GO:0090277 31 0.011
negative regulation of leukocyte apoptotic process GO:2000107 31 0.011
positive regulation of hormone secretion GO:0046887 38 0.011
reactive nitrogen species metabolic process GO:2001057 0 0.011
anatomical structure homeostasis GO:0060249 145 0.011
cellular response to carbohydrate stimulus GO:0071322 50 0.011
negative regulation of neuron death GO:1901215 98 0.011
regulation of reactive oxygen species metabolic process GO:2000377 40 0.011
eye photoreceptor cell differentiation GO:0001754 41 0.011
cellular protein catabolic process GO:0044257 155 0.011
membrane organization GO:0061024 245 0.011
nucleoside triphosphate catabolic process GO:0009143 205 0.011
negative regulation of apoptotic signaling pathway GO:2001234 104 0.011
adult behavior GO:0030534 135 0.010
mitotic nuclear division GO:0007067 48 0.010
negative regulation of cell cycle GO:0045786 123 0.010
organophosphate catabolic process GO:0046434 232 0.010
chromatin organization GO:0006325 206 0.010
cytoskeleton dependent intracellular transport GO:0030705 50 0.010
oocyte construction GO:0007308 2 0.010
regulation of transcription from rna polymerase ii promoter in response to hypoxia GO:0061418 2 0.010
establishment or maintenance of cytoskeleton polarity GO:0030952 2 0.010
metal ion homeostasis GO:0055065 189 0.010
actin polymerization or depolymerization GO:0008154 54 0.010
purine ribonucleoside metabolic process GO:0046128 241 0.010
cartilage development GO:0051216 140 0.010
inorganic cation transmembrane transport GO:0098662 207 0.010
sensory organ morphogenesis GO:0090596 242 0.010
ossification GO:0001503 216 0.010
positive regulation of protein phosphorylation GO:0001934 242 0.010
regulation of microtubule cytoskeleton organization GO:0070507 37 0.010
regulation of protein serine threonine kinase activity GO:0071900 157 0.010
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.010
positive regulation of cell death GO:0010942 224 0.010
cellular glucose homeostasis GO:0001678 52 0.010
g protein coupled receptor signaling pathway GO:0007186 243 0.010
mrna metabolic process GO:0016071 84 0.010
regulation of microtubule polymerization or depolymerization GO:0031110 20 0.010
myosin filament organization GO:0031033 3 0.010
cellular response to oxygen levels GO:0071453 20 0.010

P4htm disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.034
nervous system disease DOID:863 0 0.034
central nervous system disease DOID:331 0 0.017
eye disease DOID:5614 0 0.012
eye and adnexa disease DOID:1492 0 0.012
sensory system disease DOID:0050155 0 0.012
immune system disease DOID:2914 0 0.011
neurodegenerative disease DOID:1289 0 0.011