Mus musculus

55 known processes

Parp1

poly (ADP-ribose) polymerase family, member 1

(Aliases: Adprp,PPOL,parp-1,AI893648,sPARP-1,PARP,5830444G22Rik,C80510,Adprt1)

Parp1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
dna metabolic process GO:0006259 303 0.995
dna repair GO:0006281 107 0.912
cellular response to dna damage stimulus GO:0006974 207 0.895
chromatin organization GO:0006325 206 0.745
meiotic cell cycle process GO:1903046 77 0.558
cell fate commitment GO:0045165 210 0.468
regulation of transcription involved in g1 s transition of mitotic cell cycle GO:0000083 3 0.459
peptidyl amino acid modification GO:0018193 336 0.413
response to radiation GO:0009314 165 0.387
dna recombination GO:0006310 92 0.379
regulation of cellular catabolic process GO:0031329 242 0.373
regulation of cell cycle GO:0051726 281 0.371
meiotic cell cycle GO:0051321 122 0.324
negative regulation of cellular protein metabolic process GO:0032269 247 0.319
negative regulation of cell cycle GO:0045786 123 0.310
apoptotic signaling pathway GO:0097190 306 0.308
cellular amino acid metabolic process GO:0006520 103 0.302
macromolecule catabolic process GO:0009057 281 0.294
dendrite development GO:0016358 115 0.288
positive regulation of protein modification process GO:0031401 299 0.283
cellular macromolecule catabolic process GO:0044265 206 0.279
positive regulation of programmed cell death GO:0043068 218 0.278
intrinsic apoptotic signaling pathway GO:0097193 132 0.257
covalent chromatin modification GO:0016569 163 0.253
cell cycle checkpoint GO:0000075 47 0.253
regulation of mitotic cell cycle phase transition GO:1901990 73 0.246
heterocycle catabolic process GO:0046700 280 0.234
protein modification by small protein conjugation or removal GO:0070647 207 0.234
regulation of cellular ketone metabolic process GO:0010565 66 0.227
regulation of organelle organization GO:0033043 289 0.225
dna conformation change GO:0071103 37 0.225
regulation of cellular amine metabolic process GO:0033238 20 0.212
meiosis i GO:0007127 60 0.208
chromatin modification GO:0016568 187 0.208
organic cyclic compound catabolic process GO:1901361 295 0.208
intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 35 0.198
negative regulation of cellular component organization GO:0051129 194 0.180
histone modification GO:0016570 159 0.178
dna alkylation GO:0006305 43 0.170
cellular amine metabolic process GO:0044106 44 0.154
regulation of chromatin modification GO:1903308 57 0.154
positive regulation of chromatin modification GO:1903310 28 0.147
response to ionizing radiation GO:0010212 42 0.143
macromolecule methylation GO:0043414 120 0.142
response to light stimulus GO:0009416 135 0.142
cellular response to oxidative stress GO:0034599 76 0.140
recombinational repair GO:0000725 21 0.138
skeletal system development GO:0001501 356 0.138
regulation of cell cycle process GO:0010564 160 0.133
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 57 0.132
chromosome segregation GO:0007059 48 0.132
regulation of histone methylation GO:0031060 30 0.130
negative regulation of dna replication GO:0008156 4 0.126
gene silencing GO:0016458 38 0.126
methylation GO:0032259 134 0.123
positive regulation of histone h3 k4 methylation GO:0051571 5 0.122
positive regulation of cell death GO:0010942 224 0.122
oxidation reduction process GO:0055114 342 0.120
cellular ketone metabolic process GO:0042180 84 0.120
dna damage checkpoint GO:0000077 26 0.120
negative regulation of protein modification process GO:0031400 163 0.119
nuclear division GO:0000280 158 0.117
dna methylation GO:0006306 43 0.115
protein methylation GO:0006479 81 0.114
negative regulation of organelle organization GO:0010639 90 0.113
posttranscriptional regulation of gene expression GO:0010608 155 0.111
nucleotide excision repair GO:0006289 13 0.111
cellular hyperosmotic salinity response GO:0071475 0 0.111
response to organonitrogen compound GO:0010243 246 0.111
Human
dna integrity checkpoint GO:0031570 28 0.109
regulation of multi organism process GO:0043900 111 0.103
Fly
organelle fission GO:0048285 170 0.099
chromatin silencing GO:0006342 15 0.099
positive regulation of histone modification GO:0031058 28 0.099
aromatic compound catabolic process GO:0019439 286 0.097
cellular nitrogen compound catabolic process GO:0044270 280 0.097
translation GO:0006412 93 0.093
amine metabolic process GO:0009308 45 0.090
positive regulation of apoptotic process GO:0043065 217 0.090
signal transduction by p53 class mediator GO:0072331 51 0.089
dna dependent dna replication GO:0006261 24 0.088
regulation of hydrolase activity GO:0051336 246 0.087
response to organic cyclic compound GO:0014070 198 0.087
histone methylation GO:0016571 71 0.085
rna dependent dna replication GO:0006278 3 0.084
positive regulation of chromosome organization GO:2001252 33 0.081
release of cytochrome c from mitochondria GO:0001836 23 0.081
regulation of histone modification GO:0031056 56 0.081
regulation of cellular amino acid metabolic process GO:0006521 5 0.081
positive regulation of histone methylation GO:0031062 16 0.077
histone h3 k4 methylation GO:0051568 23 0.076
organonitrogen compound biosynthetic process GO:1901566 192 0.075
Fly
homeostasis of number of cells GO:0048872 210 0.073
epithelial cell development GO:0002064 159 0.072
Fly
energy derivation by oxidation of organic compounds GO:0015980 77 0.071
circulatory system process GO:0003013 197 0.069
positive regulation of cellular amine metabolic process GO:0033240 5 0.067
dna replication GO:0006260 52 0.066
anatomical structure homeostasis GO:0060249 145 0.065
cellular response to organonitrogen compound GO:0071417 145 0.065
Human
male gamete generation GO:0048232 285 0.065
cellular response to transforming growth factor beta stimulus GO:0071560 88 0.065
Rat
protein localization to organelle GO:0033365 185 0.064
Rat Fly
response to lipopolysaccharide GO:0032496 128 0.064
negative regulation of gene expression epigenetic GO:0045814 15 0.063
leukocyte apoptotic process GO:0071887 71 0.062
cellular response to radiation GO:0071478 28 0.062
protein alkylation GO:0008213 81 0.061
response to drug GO:0042493 75 0.061
segmentation GO:0035282 93 0.061
protein processing GO:0016485 163 0.061
Rat
nuclear transport GO:0051169 139 0.060
Rat
intracellular receptor signaling pathway GO:0030522 74 0.060
germ cell development GO:0007281 185 0.060
Fly
internal protein amino acid acetylation GO:0006475 42 0.059
positive regulation of cell development GO:0010720 237 0.058
dna templated transcription termination GO:0006353 4 0.056
chromosome organization involved in meiosis GO:0070192 39 0.056
negative regulation of phosphate metabolic process GO:0045936 184 0.056
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.056
intracellular protein transport GO:0006886 204 0.054
Rat
digestive tract development GO:0048565 190 0.054
stem cell differentiation GO:0048863 268 0.053
negative regulation of molecular function GO:0044092 258 0.053
nucleic acid phosphodiester bond hydrolysis GO:0090305 49 0.053
regulation of cell cycle phase transition GO:1901987 77 0.053
base excision repair GO:0006284 9 0.052
response to molecule of bacterial origin GO:0002237 143 0.052
regulation of neuron apoptotic process GO:0043523 122 0.052
regulation of establishment of protein localization GO:0070201 181 0.051
Rat
forebrain development GO:0030900 302 0.051
dna biosynthetic process GO:0071897 22 0.051
generation of precursor metabolites and energy GO:0006091 103 0.050
protein ubiquitination GO:0016567 171 0.049
multicellular organismal homeostasis GO:0048871 164 0.049
cellular response to acid chemical GO:0071229 68 0.049
mrna transport GO:0051028 13 0.049
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.048
nucleus organization GO:0006997 45 0.048
Fly
synapsis GO:0007129 34 0.048
axon guidance GO:0007411 141 0.048
mitotic cell cycle GO:0000278 195 0.047
spermatogenesis GO:0007283 284 0.045
regulation of mrna stability GO:0043488 23 0.045
regulation of leukocyte apoptotic process GO:2000106 56 0.045
response to transforming growth factor beta GO:0071559 88 0.045
Rat
negative regulation of mitotic cell cycle GO:0045930 58 0.045
protein catabolic process GO:0030163 221 0.045
protein localization to chromosome centromeric region GO:0071459 1 0.045
response to heat GO:0009408 27 0.044
Fly
multicellular organism growth GO:0035264 161 0.044
regulation of cytoplasmic transport GO:1903649 112 0.044
Rat
connective tissue development GO:0061448 179 0.044
organelle assembly GO:0070925 177 0.044
regulation of protein localization GO:0032880 231 0.043
Rat
receptor mediated endocytosis GO:0006898 51 0.043
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.043
protein complex disassembly GO:0043241 40 0.043
telomere maintenance GO:0000723 19 0.043
axonogenesis GO:0007409 274 0.043
histone lysine methylation GO:0034968 50 0.042
regulation of cellular protein catabolic process GO:1903362 61 0.042
locomotory behavior GO:0007626 195 0.042
negative regulation of cell proliferation GO:0008285 296 0.042
blood circulation GO:0008015 195 0.042
myeloid leukocyte differentiation GO:0002573 119 0.042
regulation of neuron death GO:1901214 134 0.041
peptidyl serine modification GO:0018209 83 0.040
positive regulation of nervous system development GO:0051962 221 0.040
dna modification GO:0006304 50 0.039
regulation of intrinsic apoptotic signaling pathway GO:2001242 61 0.039
response to uv GO:0009411 44 0.039
neural tube development GO:0021915 160 0.039
cellular response to growth factor stimulus GO:0071363 197 0.038
Rat
sister chromatid segregation GO:0000819 20 0.038
rna stabilization GO:0043489 9 0.038
positive regulation of transcription elongation from rna polymerase ii promoter GO:0032968 2 0.038
muscle tissue development GO:0060537 308 0.037
cartilage development GO:0051216 140 0.037
hindbrain development GO:0030902 128 0.037
regulation of lymphocyte apoptotic process GO:0070228 41 0.036
regulation of protein kinase activity GO:0045859 232 0.036
muscle cell differentiation GO:0042692 261 0.036
nucleocytoplasmic transport GO:0006913 139 0.036
Rat
negative regulation of phosphorylation GO:0042326 166 0.035
neuron apoptotic process GO:0051402 142 0.035
mitotic nuclear division GO:0007067 48 0.035
regulation of cell division GO:0051302 76 0.035
chemotaxis GO:0006935 247 0.035
regulation of intracellular protein transport GO:0033157 82 0.035
Rat
regulation of rna stability GO:0043487 26 0.035
negative regulation of protein metabolic process GO:0051248 282 0.034
myeloid cell differentiation GO:0030099 233 0.034
regulation of cytoskeleton organization GO:0051493 122 0.033
regulation of sarcomere organization GO:0060297 4 0.033
mitochondrion organization GO:0007005 134 0.033
pancreas development GO:0031016 57 0.033
regulation of chromatin organization GO:1902275 57 0.032
reciprocal dna recombination GO:0035825 16 0.032
negative regulation of growth GO:0045926 99 0.032
response to acid chemical GO:0001101 111 0.032
nucleoside phosphate metabolic process GO:0006753 338 0.032
regulation of mitotic cell cycle GO:0007346 126 0.032
cell growth GO:0016049 130 0.032
cell type specific apoptotic process GO:0097285 268 0.032
negative regulation of chromosome organization GO:2001251 30 0.031
regulation of protein stability GO:0031647 52 0.031
retina development in camera type eye GO:0060041 119 0.031
cytokine production GO:0001816 319 0.031
mitotic cell cycle process GO:1903047 159 0.031
regulation of translation GO:0006417 71 0.031
histone acetylation GO:0016573 41 0.031
microtubule nucleation GO:0007020 2 0.030
positive regulation of cell cycle GO:0045787 92 0.030
cellular homeostasis GO:0019725 240 0.030
regionalization GO:0003002 337 0.029
Fly
digestive system development GO:0055123 200 0.029
positive regulation of hydrolase activity GO:0051345 148 0.029
cellularization GO:0007349 1 0.029
lymphocyte apoptotic process GO:0070227 54 0.029
cellular protein complex assembly GO:0043623 116 0.029
establishment of protein localization to organelle GO:0072594 118 0.028
Rat
mitotic g2 dna damage checkpoint GO:0007095 8 0.028
regulation of cellular component biogenesis GO:0044087 181 0.028
somite development GO:0061053 81 0.028
signal transduction involved in cell cycle checkpoint GO:0072395 3 0.028
regulation of response to dna damage stimulus GO:2001020 34 0.028
negative regulation of chromatin modification GO:1903309 19 0.028
epithelial cell proliferation GO:0050673 174 0.027
sensory perception GO:0007600 245 0.027
telencephalon development GO:0021537 186 0.027
cellular response to inorganic substance GO:0071241 37 0.027
endocytosis GO:0006897 168 0.027
regulation of kinase activity GO:0043549 249 0.027
epidermis development GO:0008544 187 0.027
regulation of reproductive process GO:2000241 66 0.026
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.026
negative regulation of cellular amine metabolic process GO:0033239 1 0.026
positive regulation of cell morphogenesis involved in differentiation GO:0010770 72 0.026
protein modification by small protein conjugation GO:0032446 187 0.026
somatic diversification of immune receptors GO:0002200 53 0.026
dna hypermethylation GO:0044026 3 0.026
positive regulation of reproductive process GO:2000243 19 0.026
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.025
Rat
telomere maintenance via telomerase GO:0007004 1 0.025
signal transduction involved in mitotic dna damage checkpoint GO:1902402 3 0.025
negative regulation of transcription involved in g1 s transition of mitotic cell cycle GO:0071930 1 0.025
response to extracellular stimulus GO:0009991 127 0.025
small gtpase mediated signal transduction GO:0007264 97 0.024
cellular response to cytokine stimulus GO:0071345 189 0.024
regulation of protein transport GO:0051223 163 0.024
Rat
purine containing compound metabolic process GO:0072521 311 0.024
gonad development GO:0008406 141 0.024
skin development GO:0043588 220 0.024
columnar cuboidal epithelial cell differentiation GO:0002065 82 0.024
Fly
neuron projection guidance GO:0097485 141 0.023
inflammatory response GO:0006954 244 0.023
regulation of neuron projection development GO:0010975 169 0.023
negative regulation of neuron death GO:1901215 98 0.023
regulation of neuron differentiation GO:0045664 281 0.023
organophosphate biosynthetic process GO:0090407 122 0.023
regulation of intracellular transport GO:0032386 159 0.023
Rat
response to metal ion GO:0010038 47 0.023
negative regulation of proteolysis GO:0045861 74 0.023
peptidyl threonine modification GO:0018210 31 0.023
positive regulation of keratinocyte proliferation GO:0010838 4 0.023
regulation of apoptotic signaling pathway GO:2001233 197 0.023
protein autophosphorylation GO:0046777 61 0.023
regulation of protein modification by small protein conjugation or removal GO:1903320 57 0.023
extrinsic apoptotic signaling pathway GO:0097191 126 0.023
mitotic cell cycle checkpoint GO:0007093 31 0.023
double strand break repair GO:0006302 48 0.023
ras protein signal transduction GO:0007265 77 0.022
leukocyte differentiation GO:0002521 342 0.022
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 68 0.022
epithelial tube morphogenesis GO:0060562 303 0.022
morphogenesis of embryonic epithelium GO:0016331 159 0.022
viral process GO:0016032 41 0.022
glycosyl compound metabolic process GO:1901657 246 0.022
neuron migration GO:0001764 122 0.022
regulation of transferase activity GO:0051338 263 0.022
cellular lipid metabolic process GO:0044255 323 0.022
cell division GO:0051301 120 0.022
response to decreased oxygen levels GO:0036293 59 0.022
response to oxidative stress GO:0006979 123 0.022
anoikis GO:0043276 6 0.022
regulation of proteasomal protein catabolic process GO:0061136 46 0.022
ossification GO:0001503 216 0.022
cellular response to lipid GO:0071396 145 0.022
regulation of defense response GO:0031347 233 0.021
Fly
response to testosterone GO:0033574 3 0.021
developmental growth involved in morphogenesis GO:0060560 138 0.021
rna interference GO:0016246 2 0.021
regulation of proteolysis GO:0030162 164 0.021
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 56 0.021
protein modification by small protein removal GO:0070646 21 0.021
histone h4 k16 acetylation GO:0043984 3 0.020
exocrine pancreas development GO:0031017 7 0.020
regulation of protein catabolic process GO:0042176 108 0.020
mitotic g1 dna damage checkpoint GO:0031571 4 0.020
dna packaging GO:0006323 30 0.020
telomere capping GO:0016233 4 0.020
reactive oxygen species metabolic process GO:0072593 84 0.020
regulation of system process GO:0044057 200 0.020
macromolecular complex disassembly GO:0032984 43 0.020
negative regulation of cell cycle phase transition GO:1901988 48 0.020
double strand break repair via homologous recombination GO:0000724 21 0.020
regulation of peptidyl lysine acetylation GO:2000756 22 0.020
regulation of cell growth GO:0001558 91 0.020
regulation of endopeptidase activity GO:0052548 89 0.020
blastocyst development GO:0001824 80 0.020
intracellular mrna localization GO:0008298 4 0.020
rhythmic process GO:0048511 174 0.020
regulation of chromosome organization GO:0033044 83 0.020
regulation of cell motility GO:2000145 236 0.020
coenzyme metabolic process GO:0006732 52 0.020
negative regulation of apoptotic signaling pathway GO:2001234 104 0.020
cellular response to abiotic stimulus GO:0071214 56 0.020
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.020
hematopoietic progenitor cell differentiation GO:0002244 143 0.019
sensory organ morphogenesis GO:0090596 242 0.019
stem cell development GO:0048864 219 0.019
dna dependent dna replication maintenance of fidelity GO:0045005 3 0.019
lens fiber cell apoptotic process GO:1990086 4 0.019
multi multicellular organism process GO:0044706 109 0.019
cellular response to external stimulus GO:0071496 88 0.019
regulation of striated muscle cell differentiation GO:0051153 81 0.019
cellular component assembly involved in morphogenesis GO:0010927 139 0.019
developmental programmed cell death GO:0010623 41 0.019
protein targeting GO:0006605 143 0.019
Rat
divalent metal ion transport GO:0070838 172 0.018
cellular response to metal ion GO:0071248 31 0.018
regulation of transcription by chromatin organization GO:0034401 0 0.018
leukocyte proliferation GO:0070661 172 0.018
regulation of protein maturation GO:1903317 96 0.018
negative regulation of immune system process GO:0002683 209 0.018
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 62 0.018
regulation of protein serine threonine kinase activity GO:0071900 157 0.018
negative regulation of cell cycle process GO:0010948 69 0.018
histone deacetylation GO:0016575 26 0.018
metencephalon development GO:0022037 89 0.018
carbohydrate derivative biosynthetic process GO:1901137 183 0.018
Human Rat Fly
regulation of cytokine production GO:0001817 266 0.018
mesoderm development GO:0007498 100 0.018
regulation of microtubule polymerization or depolymerization GO:0031110 20 0.018
neuron death GO:0070997 154 0.018
t cell proliferation GO:0042098 120 0.017
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 52 0.017
oogenesis GO:0048477 56 0.017
Fly
negative regulation of intrinsic apoptotic signaling pathway GO:2001243 34 0.017
dna catabolic process GO:0006308 19 0.017
regulation of angiogenesis GO:0045765 81 0.017
cardiocyte differentiation GO:0035051 87 0.017
genitalia development GO:0048806 37 0.017
positive regulation of organelle organization GO:0010638 128 0.017
striated muscle tissue development GO:0014706 293 0.017
nucleoside phosphate biosynthetic process GO:1901293 79 0.017
cell cycle arrest GO:0007050 37 0.017
heart process GO:0003015 94 0.017
gene silencing by rna GO:0031047 19 0.016
negative regulation of intracellular signal transduction GO:1902532 167 0.016
response to alkaloid GO:0043279 34 0.016
nuclear export GO:0051168 34 0.016
negative regulation of nervous system development GO:0051961 156 0.016
negative regulation of protein maturation GO:1903318 79 0.016
programmed necrotic cell death GO:0097300 28 0.016
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.016
meiotic nuclear division GO:0007126 115 0.016
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 36 0.016
cellular chemical homeostasis GO:0055082 215 0.016
somitogenesis GO:0001756 69 0.016
pallium development GO:0021543 120 0.016
peptidyl threonine phosphorylation GO:0018107 31 0.016
blood vessel morphogenesis GO:0048514 285 0.016
rna 3 end processing GO:0031123 20 0.016
organonitrogen compound catabolic process GO:1901565 264 0.016
negative regulation of viral process GO:0048525 23 0.016
hippocampus development GO:0021766 52 0.015
leukocyte activation involved in immune response GO:0002366 126 0.015
purine ribonucleoside catabolic process GO:0046130 205 0.015
mesenchymal cell development GO:0014031 93 0.015
gliogenesis GO:0042063 141 0.015
dna replication checkpoint GO:0000076 2 0.015
negative regulation of neuron apoptotic process GO:0043524 92 0.015
exocrine system development GO:0035272 45 0.015
cellular ion homeostasis GO:0006873 165 0.015
mrna stabilization GO:0048255 9 0.015
negative regulation of wnt signaling pathway GO:0030178 73 0.015
fat cell differentiation GO:0045444 160 0.015
ameboidal type cell migration GO:0001667 128 0.015
ubiquitin dependent protein catabolic process GO:0006511 129 0.015
response to oxygen levels GO:0070482 62 0.015
adult behavior GO:0030534 135 0.015
actin cytoskeleton organization GO:0030036 220 0.015
response to purine containing compound GO:0014074 28 0.015
regulation of anatomical structure size GO:0090066 178 0.015
t cell differentiation in thymus GO:0033077 77 0.015
response to inorganic substance GO:0010035 96 0.015
microtubule based process GO:0007017 236 0.015
posttranscriptional gene silencing GO:0016441 10 0.015
regulation of membrane potential GO:0042391 192 0.015
intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 19 0.015
response to reactive oxygen species GO:0000302 56 0.015
negative regulation of phosphorus metabolic process GO:0010563 184 0.015
divalent inorganic cation transport GO:0072511 178 0.015
nitrogen compound transport GO:0071705 271 0.015
negative regulation of protein processing GO:0010955 79 0.014
negative regulation of viral genome replication GO:0045071 10 0.014
positive regulation of fibroblast proliferation GO:0048146 20 0.014
transmembrane transport GO:0055085 412 0.014
camera type eye development GO:0043010 266 0.014
cellular calcium ion homeostasis GO:0006874 119 0.014
dna damage response signal transduction by p53 class mediator GO:0030330 19 0.014
cognition GO:0050890 149 0.014
apoptotic process involved in development GO:1902742 28 0.014
cation transport GO:0006812 399 0.014
somatic recombination of immunoglobulin gene segments GO:0016447 42 0.014
female gamete generation GO:0007292 74 0.014
Fly
somatic diversification of immunoglobulins GO:0016445 43 0.014
negative regulation of multi organism process GO:0043901 68 0.014
purine nucleoside catabolic process GO:0006152 205 0.014
regulation of protein localization to nucleus GO:1900180 60 0.014
Rat
action potential GO:0001508 78 0.014
lymphocyte proliferation GO:0046651 164 0.014
regulation of secretion by cell GO:1903530 249 0.014
negative regulation of kinase activity GO:0033673 81 0.014
heart contraction GO:0060047 93 0.014
glial cell differentiation GO:0010001 131 0.014
nucleobase containing small molecule metabolic process GO:0055086 352 0.014
humoral immune response GO:0006959 57 0.014
Fly
response to endoplasmic reticulum stress GO:0034976 53 0.013
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.013
lipid biosynthetic process GO:0008610 179 0.013
regulation of b cell activation GO:0050864 81 0.013
calcium ion transport GO:0006816 159 0.013
regulation of peptidase activity GO:0052547 96 0.013
response to gamma radiation GO:0010332 22 0.013
regulation of lymphocyte activation GO:0051249 240 0.013
cellular response to light stimulus GO:0071482 19 0.013
purine ribonucleoside metabolic process GO:0046128 241 0.013
rna catabolic process GO:0006401 29 0.013
regulation of homeostatic process GO:0032844 182 0.013
epithelial tube formation GO:0072175 130 0.013
small molecule biosynthetic process GO:0044283 132 0.013
negative regulation of histone h3 k9 methylation GO:0051573 4 0.013
interspecies interaction between organisms GO:0044419 83 0.013
production of molecular mediator of immune response GO:0002440 103 0.013
Fly
response to estrogen GO:0043627 24 0.013
learning or memory GO:0007611 148 0.013
regulation of histone h3 k4 methylation GO:0051569 12 0.013
peptidyl tyrosine modification GO:0018212 145 0.013
somatic cell dna recombination GO:0016444 51 0.013
cell activation involved in immune response GO:0002263 126 0.013
protein desumoylation GO:0016926 2 0.013
glandular epithelial cell differentiation GO:0002067 38 0.013
histone h4 acetylation GO:0043967 10 0.013
g protein coupled receptor signaling pathway GO:0007186 243 0.013
epidermal cell division GO:0010481 3 0.013
engulfment of apoptotic cell GO:0043652 3 0.013
positive regulation of endopeptidase activity GO:0010950 43 0.013
immune effector process GO:0002252 321 0.013
Fly
regulation of nuclear division GO:0051783 56 0.013
negative regulation of protein phosphorylation GO:0001933 126 0.013
regulation of mitosis GO:0007088 29 0.013
regulation of blood circulation GO:1903522 93 0.013
cellular respiration GO:0045333 38 0.013
regulation of wnt signaling pathway GO:0030111 123 0.013
ribonucleotide catabolic process GO:0009261 208 0.013
positive regulation of protein transport GO:0051222 93 0.013
Rat
limbic system development GO:0021761 72 0.012
purine nucleoside triphosphate metabolic process GO:0009144 226 0.012
negative regulation of histone methylation GO:0031061 10 0.012
cell fate determination GO:0001709 32 0.012
protein deacetylation GO:0006476 32 0.012
somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 51 0.012
b cell activation GO:0042113 161 0.012
positive regulation of neuron differentiation GO:0045666 141 0.012
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 45 0.012
immunoglobulin mediated immune response GO:0016064 69 0.012
hatching GO:0035188 4 0.012

Parp1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.136
disease of cellular proliferation DOID:14566 0 0.136
organ system cancer DOID:0050686 0 0.136
disease of anatomical entity DOID:7 0 0.041
nervous system disease DOID:863 0 0.041
hereditary sensory neuropathy DOID:0050548 0 0.029
peripheral neuropathy DOID:0060053 0 0.029
neuropathy DOID:870 0 0.029
gastrointestinal system cancer DOID:3119 0 0.022
intestinal cancer DOID:10155 0 0.022
retinal disease DOID:5679 0 0.014
retinal degeneration DOID:8466 0 0.014
sensory system disease DOID:0050155 0 0.014
eye and adnexa disease DOID:1492 0 0.014
eye disease DOID:5614 0 0.014