Mus musculus

5 known processes

Pdha1

pyruvate dehydrogenase E1 alpha 1

(Aliases: Pdha-1)

Pdha1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
energy derivation by oxidation of organic compounds GO:0015980 77 0.361
oxidation reduction process GO:0055114 342 0.326
generation of precursor metabolites and energy GO:0006091 103 0.289
coenzyme metabolic process GO:0006732 52 0.243
sulfur compound biosynthetic process GO:0044272 37 0.201
nadh metabolic process GO:0006734 1 0.150
monocarboxylic acid metabolic process GO:0032787 191 0.150
cellular amino acid metabolic process GO:0006520 103 0.139
organic acid biosynthetic process GO:0016053 86 0.119
cofactor metabolic process GO:0051186 80 0.118
coenzyme biosynthetic process GO:0009108 23 0.117
nucleobase containing small molecule metabolic process GO:0055086 352 0.107
cellular ketone metabolic process GO:0042180 84 0.104
acetyl coa biosynthetic process GO:0006085 5 0.094
cation transport GO:0006812 399 0.084
acetyl coa biosynthetic process from pyruvate GO:0006086 3 0.080
regulation of mitochondrial fission GO:0090140 3 0.077
small molecule catabolic process GO:0044282 71 0.072
acyl coa biosynthetic process GO:0071616 7 0.070
regulation of cellular ketone metabolic process GO:0010565 66 0.067
cellular amine metabolic process GO:0044106 44 0.067
purine ribonucleoside metabolic process GO:0046128 241 0.065
transmembrane transport GO:0055085 412 0.062
fatty acid oxidation GO:0019395 28 0.061
purine ribonucleotide metabolic process GO:0009150 290 0.060
acyl coa metabolic process GO:0006637 19 0.060
nucleotide metabolic process GO:0009117 332 0.058
ion transmembrane transport GO:0034220 361 0.057
carboxylic acid biosynthetic process GO:0046394 86 0.056
carbohydrate metabolic process GO:0005975 230 0.050
mitochondrion organization GO:0007005 134 0.050
sulfur compound metabolic process GO:0006790 100 0.048
small molecule biosynthetic process GO:0044283 132 0.047
thioester biosynthetic process GO:0035384 7 0.047
cellular homeostasis GO:0019725 240 0.047
regulation of membrane potential GO:0042391 192 0.046
t cell activation GO:0042110 289 0.045
nucleoside metabolic process GO:0009116 246 0.045
endocytosis GO:0006897 168 0.042
Worm
nucleoside phosphate biosynthetic process GO:1901293 79 0.042
gland development GO:0048732 330 0.042
purine nucleoside metabolic process GO:0042278 241 0.042
organophosphate biosynthetic process GO:0090407 122 0.041
intrinsic apoptotic signaling pathway GO:0097193 132 0.041
lipid oxidation GO:0034440 29 0.041
negative regulation of cellular amine metabolic process GO:0033239 1 0.040
atp metabolic process GO:0046034 75 0.040
cellular lipid metabolic process GO:0044255 323 0.040
nucleoside phosphate metabolic process GO:0006753 338 0.040
organonitrogen compound biosynthetic process GO:1901566 192 0.039
lipid biosynthetic process GO:0008610 179 0.039
cellular carbohydrate metabolic process GO:0044262 119 0.038
regulation of cellular amine metabolic process GO:0033238 20 0.038
regulation of mitochondrion organization GO:0010821 27 0.038
amine metabolic process GO:0009308 45 0.037
action potential GO:0001508 78 0.037
membrane organization GO:0061024 245 0.037
organic acid catabolic process GO:0016054 51 0.037
organic cyclic compound catabolic process GO:1901361 295 0.036
regulation of cellular amino acid metabolic process GO:0006521 5 0.035
organonitrogen compound catabolic process GO:1901565 264 0.035
heterocycle catabolic process GO:0046700 280 0.034
regulation of organelle organization GO:0033043 289 0.034
carboxylic acid catabolic process GO:0046395 51 0.033
ribonucleotide metabolic process GO:0009259 291 0.033
cation transmembrane transport GO:0098655 266 0.033
forebrain development GO:0030900 302 0.032
hexose metabolic process GO:0019318 98 0.032
organic hydroxy compound metabolic process GO:1901615 203 0.032
lipid localization GO:0010876 126 0.031
cellular respiration GO:0045333 38 0.031
nucleoside triphosphate metabolic process GO:0009141 230 0.031
synapse organization GO:0050808 125 0.030
carbohydrate derivative biosynthetic process GO:1901137 183 0.030
aromatic compound catabolic process GO:0019439 286 0.030
striated muscle tissue development GO:0014706 293 0.030
ribose phosphate metabolic process GO:0019693 291 0.029
regulation of cell activation GO:0050865 289 0.029
cellular amino acid catabolic process GO:0009063 25 0.028
maintenance of location GO:0051235 89 0.028
inorganic ion transmembrane transport GO:0098660 234 0.028
glycosyl compound metabolic process GO:1901657 246 0.027
spermatogenesis GO:0007283 284 0.027
cell type specific apoptotic process GO:0097285 268 0.027
transmission of nerve impulse GO:0019226 76 0.027
muscle tissue development GO:0060537 308 0.026
blood vessel morphogenesis GO:0048514 285 0.026
negative regulation of cell proliferation GO:0008285 296 0.026
positive regulation of apoptotic process GO:0043065 217 0.026
purine nucleoside monophosphate metabolic process GO:0009126 81 0.026
monocarboxylic acid biosynthetic process GO:0072330 61 0.026
regulation of protein transport GO:0051223 163 0.026
cation homeostasis GO:0055080 212 0.025
lymphocyte proliferation GO:0046651 164 0.025
regulation of transmembrane transport GO:0034762 128 0.025
apoptotic mitochondrial changes GO:0008637 48 0.025
ribonucleoside metabolic process GO:0009119 245 0.024
nucleoside monophosphate metabolic process GO:0009123 85 0.024
organelle fission GO:0048285 170 0.024
citrate metabolic process GO:0006101 3 0.024
purine nucleotide biosynthetic process GO:0006164 65 0.024
positive regulation of organelle organization GO:0010638 128 0.024
regulation of cellular response to stress GO:0080135 159 0.023
anatomical structure homeostasis GO:0060249 145 0.023
cell adhesion GO:0007155 329 0.023
neural tube formation GO:0001841 108 0.023
regulation of secretion by cell GO:1903530 249 0.023
regulation of protein localization GO:0032880 231 0.023
inorganic cation transmembrane transport GO:0098662 207 0.023
regulation of lymphocyte activation GO:0051249 240 0.022
nucleotide biosynthetic process GO:0009165 78 0.022
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.022
thioester metabolic process GO:0035383 19 0.022
amp metabolic process GO:0046033 4 0.022
angiogenesis GO:0001525 201 0.021
glycerophospholipid metabolic process GO:0006650 71 0.021
regulation of apoptotic signaling pathway GO:2001233 197 0.021
purine containing compound metabolic process GO:0072521 311 0.021
monosaccharide metabolic process GO:0005996 106 0.021
neuron apoptotic process GO:0051402 142 0.021
nuclear transport GO:0051169 139 0.021
monosaccharide biosynthetic process GO:0046364 44 0.021
multi multicellular organism process GO:0044706 109 0.020
telencephalon development GO:0021537 186 0.020
sensory perception GO:0007600 245 0.020
posttranscriptional regulation of gene expression GO:0010608 155 0.020
heart morphogenesis GO:0003007 178 0.020
positive regulation of cellular amine metabolic process GO:0033240 5 0.019
regulation of intracellular transport GO:0032386 159 0.019
ras protein signal transduction GO:0007265 77 0.019
nucleocytoplasmic transport GO:0006913 139 0.019
positive regulation of protein kinase activity GO:0045860 144 0.019
regulation of ion transmembrane transport GO:0034765 119 0.019
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.019
succinyl coa metabolic process GO:0006104 1 0.019
nitrogen compound transport GO:0071705 271 0.019
cardiac muscle tissue development GO:0048738 130 0.019
negative regulation of molecular function GO:0044092 258 0.019
mitochondrial fusion GO:0008053 9 0.019
cellular chemical homeostasis GO:0055082 215 0.019
muscle cell differentiation GO:0042692 261 0.019
purine ribonucleotide catabolic process GO:0009154 208 0.019
cellular ion homeostasis GO:0006873 165 0.019
negative regulation of intracellular signal transduction GO:1902532 167 0.019
multicellular organismal signaling GO:0035637 91 0.018
ossification GO:0001503 216 0.018
fatty acid metabolic process GO:0006631 121 0.018
organic hydroxy compound biosynthetic process GO:1901617 77 0.018
cytokine production GO:0001816 319 0.018
glycogen metabolic process GO:0005977 32 0.018
locomotory behavior GO:0007626 195 0.018
regulation of neuron differentiation GO:0045664 281 0.018
ribonucleoside monophosphate metabolic process GO:0009161 80 0.018
cellular response to hormone stimulus GO:0032870 150 0.018
carbohydrate biosynthetic process GO:0016051 74 0.018
iron sulfur cluster assembly GO:0016226 3 0.018
protein processing GO:0016485 163 0.018
regulation of mapk cascade GO:0043408 248 0.018
regulation of carbohydrate metabolic process GO:0006109 75 0.017
cellular response to molecule of bacterial origin GO:0071219 83 0.017
nicotinamide nucleotide metabolic process GO:0046496 12 0.017
homeostasis of number of cells GO:0048872 210 0.017
morphogenesis of embryonic epithelium GO:0016331 159 0.017
response to oxidative stress GO:0006979 123 0.017
epithelial tube morphogenesis GO:0060562 303 0.017
phagocytosis GO:0006909 66 0.017
response to organonitrogen compound GO:0010243 246 0.017
response to inorganic substance GO:0010035 96 0.017
dicarboxylic acid metabolic process GO:0043648 18 0.017
dna metabolic process GO:0006259 303 0.017
phospholipid metabolic process GO:0006644 87 0.017
regulation of ion transport GO:0043269 215 0.017
ribose phosphate biosynthetic process GO:0046390 59 0.017
cellular response to biotic stimulus GO:0071216 92 0.017
epithelial cell proliferation GO:0050673 174 0.017
purine nucleoside triphosphate metabolic process GO:0009144 226 0.017
positive regulation of cell death GO:0010942 224 0.017
myeloid cell differentiation GO:0030099 233 0.017
regulation of anatomical structure size GO:0090066 178 0.017
regulation of protein kinase activity GO:0045859 232 0.016
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.016
primary neural tube formation GO:0014020 95 0.016
regulation of metal ion transport GO:0010959 106 0.016
regulation of cellular carbohydrate metabolic process GO:0010675 75 0.016
purine containing compound biosynthetic process GO:0072522 70 0.016
regulation of secretion GO:0051046 274 0.016
engulfment of apoptotic cell GO:0043652 3 0.016
purine nucleotide catabolic process GO:0006195 211 0.016
negative regulation of phosphorylation GO:0042326 166 0.016
response to molecule of bacterial origin GO:0002237 143 0.016
regulation of glucose metabolic process GO:0010906 60 0.016
ribonucleotide biosynthetic process GO:0009260 59 0.016
purine ribonucleotide biosynthetic process GO:0009152 59 0.016
negative regulation of phosphorus metabolic process GO:0010563 184 0.016
alpha amino acid catabolic process GO:1901606 18 0.016
protein secretion GO:0009306 111 0.016
purine ribonucleoside biosynthetic process GO:0046129 19 0.016
regulation of cytokine production GO:0001817 266 0.016
lymphocyte differentiation GO:0030098 242 0.016
alcohol metabolic process GO:0006066 116 0.016
skeletal system development GO:0001501 356 0.015
cellular response to lipid GO:0071396 145 0.015
energy reserve metabolic process GO:0006112 39 0.015
regulation of cellular component biogenesis GO:0044087 181 0.015
oxidoreduction coenzyme metabolic process GO:0006733 16 0.015
mitotic cell cycle GO:0000278 195 0.015
cardiocyte differentiation GO:0035051 87 0.015
regulation of transferase activity GO:0051338 263 0.015
leukocyte differentiation GO:0002521 342 0.015
positive regulation of protein modification process GO:0031401 299 0.015
negative regulation of cellular component organization GO:0051129 194 0.015
stem cell differentiation GO:0048863 268 0.015
organelle localization GO:0051640 179 0.015
water soluble vitamin biosynthetic process GO:0042364 3 0.015
regulation of hydrolase activity GO:0051336 246 0.014
response to oxygen radical GO:0000305 16 0.014
intracellular protein transport GO:0006886 204 0.014
ribonucleoside catabolic process GO:0042454 206 0.014
mitochondrial membrane organization GO:0007006 26 0.014
mapk cascade GO:0000165 281 0.014
ribonucleoside monophosphate biosynthetic process GO:0009156 9 0.014
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.014
cofactor transport GO:0051181 4 0.014
cofactor biosynthetic process GO:0051188 41 0.014
regulation of homeostatic process GO:0032844 182 0.014
small gtpase mediated signal transduction GO:0007264 97 0.014
neural tube development GO:0021915 160 0.014
response to lipopolysaccharide GO:0032496 128 0.014
immune effector process GO:0002252 321 0.014
peptidyl amino acid modification GO:0018193 336 0.014
anion transport GO:0006820 177 0.014
cytoplasmic transport GO:0016482 234 0.014
leukocyte proliferation GO:0070661 172 0.014
hepaticobiliary system development GO:0061008 67 0.014
4 hydroxyproline metabolic process GO:0019471 5 0.014
purine nucleotide metabolic process GO:0006163 302 0.014
regulation of neuron death GO:1901214 134 0.014
multicellular organismal homeostasis GO:0048871 164 0.014
innate immune response GO:0045087 157 0.014
regulation of ion transmembrane transporter activity GO:0032412 54 0.014
carbohydrate derivative catabolic process GO:1901136 231 0.014
neuron death GO:0070997 154 0.014
cellular response to lipopolysaccharide GO:0071222 77 0.014
cellular response to organonitrogen compound GO:0071417 145 0.013
regulation of map kinase activity GO:0043405 120 0.013
tricarboxylic acid metabolic process GO:0072350 5 0.013
calcium ion homeostasis GO:0055074 127 0.013
ribonucleoside triphosphate metabolic process GO:0009199 220 0.013
positive regulation of mapk cascade GO:0043410 170 0.013
regulation of protein complex assembly GO:0043254 83 0.013
glucose metabolic process GO:0006006 92 0.013
apoptotic signaling pathway GO:0097190 306 0.013
t cell proliferation GO:0042098 120 0.013
divalent metal ion transport GO:0070838 172 0.013
male gamete generation GO:0048232 285 0.013
tube closure GO:0060606 91 0.013
response to reactive oxygen species GO:0000302 56 0.013
regulation of transporter activity GO:0032409 57 0.013
pyridine nucleotide metabolic process GO:0019362 12 0.013
ribonucleotide catabolic process GO:0009261 208 0.013
regulation of neurotransmitter levels GO:0001505 87 0.013
protein oligomerization GO:0051259 67 0.013
circulatory system process GO:0003013 197 0.013
response to organic cyclic compound GO:0014070 198 0.013
camera type eye development GO:0043010 266 0.013
fatty acid catabolic process GO:0009062 25 0.013
protein homooligomerization GO:0051260 43 0.013
cellular polysaccharide metabolic process GO:0044264 38 0.013
positive regulation of cell activation GO:0050867 158 0.012
nuclear division GO:0000280 158 0.012
regulation of reactive oxygen species metabolic process GO:2000377 40 0.012
regulation of neuron apoptotic process GO:0043523 122 0.012
negative regulation of cellular protein metabolic process GO:0032269 247 0.012
meiotic nuclear division GO:0007126 115 0.012
regulation of response to wounding GO:1903034 189 0.012
metal ion homeostasis GO:0055065 189 0.012
response to acid chemical GO:0001101 111 0.012
embryonic epithelial tube formation GO:0001838 130 0.012
negative regulation of protein metabolic process GO:0051248 282 0.012
response to steroid hormone GO:0048545 56 0.012
leukocyte mediated immunity GO:0002443 174 0.012
protein localization to organelle GO:0033365 185 0.012
respiratory system development GO:0060541 190 0.012
positive regulation of cell development GO:0010720 237 0.012
regulation of cell adhesion GO:0030155 154 0.012
hydrogen transport GO:0006818 35 0.012
response to nutrient levels GO:0031667 109 0.012
regulation of ras protein signal transduction GO:0046578 114 0.012
glycosyl compound biosynthetic process GO:1901659 21 0.012
inner mitochondrial membrane organization GO:0007007 5 0.012
chromatin organization GO:0006325 206 0.012
actin cytoskeleton organization GO:0030036 220 0.012
tissue homeostasis GO:0001894 115 0.012
neuronal action potential GO:0019228 54 0.012
hindbrain development GO:0030902 128 0.012
cardiac muscle cell differentiation GO:0055007 69 0.012
t cell differentiation GO:0030217 174 0.012
adult behavior GO:0030534 135 0.011
ribonucleoside biosynthetic process GO:0042455 21 0.011
sequestering of calcium ion GO:0051208 18 0.011
regulation of protein serine threonine kinase activity GO:0071900 157 0.011
cellular response to growth factor stimulus GO:0071363 197 0.011
nucleoside catabolic process GO:0009164 206 0.011
adult locomotory behavior GO:0008344 91 0.011
organic hydroxy compound transport GO:0015850 93 0.011
multicellular organism growth GO:0035264 161 0.011
microtubule based process GO:0007017 236 0.011
central nervous system neuron differentiation GO:0021953 162 0.011
skeletal system morphogenesis GO:0048705 203 0.011
divalent inorganic cation homeostasis GO:0072507 138 0.011
glutamate biosynthetic process GO:0006537 2 0.011
negative regulation of leukocyte differentiation GO:1902106 51 0.011
polysaccharide metabolic process GO:0005976 39 0.011
sodium ion transport GO:0006814 73 0.011
multicellular organismal aging GO:0010259 24 0.011
Worm
response to extracellular stimulus GO:0009991 127 0.011
ensheathment of neurons GO:0007272 76 0.011
negative regulation of organelle organization GO:0010639 90 0.011
regulation of kinase activity GO:0043549 249 0.011
purine containing compound catabolic process GO:0072523 213 0.011
olfactory bulb development GO:0021772 30 0.011
regulation of t cell activation GO:0050863 170 0.011
sensory organ morphogenesis GO:0090596 242 0.011
rna processing GO:0006396 105 0.011
cellular metal ion homeostasis GO:0006875 151 0.011
wound healing GO:0042060 157 0.011
positive regulation of programmed cell death GO:0043068 218 0.011
regulation of leukocyte differentiation GO:1902105 159 0.011
regulation of reactive oxygen species biosynthetic process GO:1903426 2 0.011
cell fate commitment GO:0045165 210 0.011
glucose homeostasis GO:0042593 128 0.011
development of primary sexual characteristics GO:0045137 143 0.011
Worm
cellularization GO:0007349 1 0.011
negative regulation of cell development GO:0010721 169 0.010
mitochondrion distribution GO:0048311 4 0.010
histone modification GO:0016570 159 0.010
negative regulation of lymphocyte activation GO:0051250 91 0.010
regulation of epithelial cell proliferation GO:0050678 141 0.010
long chain fatty acid import GO:0044539 2 0.010
synapse assembly GO:0007416 56 0.010
carnitine metabolic process GO:0009437 7 0.010
tube formation GO:0035148 140 0.010
endoplasmic reticulum tubular network organization GO:0071786 1 0.010
regulation of cytoplasmic transport GO:1903649 112 0.010
purine nucleoside biosynthetic process GO:0042451 19 0.010
protein maturation GO:0051604 176 0.010
glycerophospholipid biosynthetic process GO:0046474 32 0.010
cellular nitrogen compound catabolic process GO:0044270 280 0.010
regulation of nucleocytoplasmic transport GO:0046822 73 0.010
fat cell differentiation GO:0045444 160 0.010

Pdha1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.092
inherited metabolic disorder DOID:655 0 0.061
disease of anatomical entity DOID:7 0 0.031
nervous system disease DOID:863 0 0.031
cancer DOID:162 0 0.023
disease of cellular proliferation DOID:14566 0 0.023
organ system cancer DOID:0050686 0 0.021
amino acid metabolic disorder DOID:9252 0 0.016
endocrine gland cancer DOID:170 0 0.010