Mus musculus

0 known processes

Pdhb

pyruvate dehydrogenase (lipoamide) beta

(Aliases: AL024199,C81408,2610103L06Rik)

Pdhb biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
sulfur compound biosynthetic process GO:0044272 37 0.577
Rat
oxidation reduction process GO:0055114 342 0.298
Rat
energy derivation by oxidation of organic compounds GO:0015980 77 0.297
ribonucleoside triphosphate metabolic process GO:0009199 220 0.254
atp metabolic process GO:0046034 75 0.228
monocarboxylic acid metabolic process GO:0032787 191 0.200
Rat
generation of precursor metabolites and energy GO:0006091 103 0.184
iron sulfur cluster assembly GO:0016226 3 0.172
purine ribonucleoside metabolic process GO:0046128 241 0.144
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.141
nucleobase containing small molecule metabolic process GO:0055086 352 0.141
coenzyme biosynthetic process GO:0009108 23 0.104
Rat
organic acid biosynthetic process GO:0016053 86 0.100
sulfur compound metabolic process GO:0006790 100 0.093
Rat
glycosyl compound metabolic process GO:1901657 246 0.092
regulation of intrinsic apoptotic signaling pathway GO:2001242 61 0.091
intrinsic apoptotic signaling pathway GO:0097193 132 0.089
cellular respiration GO:0045333 38 0.086
nucleoside phosphate metabolic process GO:0006753 338 0.083
purine ribonucleotide metabolic process GO:0009150 290 0.082
carboxylic acid biosynthetic process GO:0046394 86 0.072
small molecule biosynthetic process GO:0044283 132 0.070
nucleoside metabolic process GO:0009116 246 0.068
nucleoside monophosphate metabolic process GO:0009123 85 0.068
cellular ketone metabolic process GO:0042180 84 0.066
transmembrane transport GO:0055085 412 0.064
water soluble vitamin biosynthetic process GO:0042364 3 0.062
purine nucleoside monophosphate metabolic process GO:0009126 81 0.062
ribonucleoside metabolic process GO:0009119 245 0.061
nucleotide metabolic process GO:0009117 332 0.056
ion transmembrane transport GO:0034220 361 0.056
purine nucleoside triphosphate metabolic process GO:0009144 226 0.055
apoptotic signaling pathway GO:0097190 306 0.054
male gamete generation GO:0048232 285 0.053
cellular amino acid metabolic process GO:0006520 103 0.052
purine nucleoside metabolic process GO:0042278 241 0.051
nucleoside triphosphate metabolic process GO:0009141 230 0.050
cofactor metabolic process GO:0051186 80 0.045
Rat
purine nucleotide metabolic process GO:0006163 302 0.045
aromatic compound catabolic process GO:0019439 286 0.044
lipid biosynthetic process GO:0008610 179 0.044
purine containing compound metabolic process GO:0072521 311 0.043
monocarboxylic acid biosynthetic process GO:0072330 61 0.042
spermatogenesis GO:0007283 284 0.041
mitochondrion organization GO:0007005 134 0.041
ribonucleotide metabolic process GO:0009259 291 0.039
neural tube formation GO:0001841 108 0.038
spermatid differentiation GO:0048515 115 0.037
protein localization to mitochondrion GO:0070585 15 0.036
protein maturation GO:0051604 176 0.036
ribose phosphate metabolic process GO:0019693 291 0.034
apoptotic mitochondrial changes GO:0008637 48 0.034
regulation of protein complex assembly GO:0043254 83 0.033
spermatid development GO:0007286 108 0.032
regulation of apoptotic signaling pathway GO:2001233 197 0.030
cellular amine metabolic process GO:0044106 44 0.030
metallo sulfur cluster assembly GO:0031163 3 0.030
embryonic epithelial tube formation GO:0001838 130 0.029
ribonucleoside monophosphate metabolic process GO:0009161 80 0.029
cellular macromolecule catabolic process GO:0044265 206 0.029
purine nucleoside triphosphate catabolic process GO:0009146 203 0.028
germ cell development GO:0007281 185 0.028
cellular lipid metabolic process GO:0044255 323 0.028
neural tube development GO:0021915 160 0.027
oxidative phosphorylation GO:0006119 14 0.027
organic anion transport GO:0015711 137 0.027
pyruvate transport GO:0006848 2 0.027
anion transport GO:0006820 177 0.026
response to molecule of bacterial origin GO:0002237 143 0.026
intracellular protein transport GO:0006886 204 0.025
protein localization to organelle GO:0033365 185 0.025
negative regulation of cellular component organization GO:0051129 194 0.025
water soluble vitamin metabolic process GO:0006767 10 0.025
regulation of cellular catabolic process GO:0031329 242 0.025
fatty acid biosynthetic process GO:0006633 41 0.025
regulation of cellular amine metabolic process GO:0033238 20 0.024
negative regulation of intracellular signal transduction GO:1902532 167 0.024
organic cyclic compound catabolic process GO:1901361 295 0.024
nitrogen compound transport GO:0071705 271 0.023
mitochondrial electron transport nadh to ubiquinone GO:0006120 4 0.023
regulation of cellular amino acid metabolic process GO:0006521 5 0.023
negative regulation of phosphorus metabolic process GO:0010563 184 0.023
macromolecule catabolic process GO:0009057 281 0.023
negative regulation of intrinsic apoptotic signaling pathway GO:2001243 34 0.023
regulation of membrane potential GO:0042391 192 0.022
positive regulation of cell death GO:0010942 224 0.022
heterocycle catabolic process GO:0046700 280 0.022
epithelial tube morphogenesis GO:0060562 303 0.021
establishment of protein localization to organelle GO:0072594 118 0.021
response to oxidative stress GO:0006979 123 0.021
primary neural tube formation GO:0014020 95 0.020
purine nucleoside catabolic process GO:0006152 205 0.020
purine nucleotide catabolic process GO:0006195 211 0.020
atp synthesis coupled electron transport GO:0042773 8 0.020
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.020
inflammatory response GO:0006954 244 0.019
positive regulation of protein modification process GO:0031401 299 0.019
negative regulation of cell proliferation GO:0008285 296 0.019
mitochondrial transport GO:0006839 36 0.019
negative regulation of phosphorylation GO:0042326 166 0.019
coenzyme metabolic process GO:0006732 52 0.019
Rat
cellular amide metabolic process GO:0043603 58 0.018
carbohydrate metabolic process GO:0005975 230 0.018
cell type specific apoptotic process GO:0097285 268 0.018
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.018
reactive oxygen species metabolic process GO:0072593 84 0.018
protein targeting GO:0006605 143 0.018
mapk cascade GO:0000165 281 0.018
succinyl coa metabolic process GO:0006104 1 0.018
negative regulation of apoptotic signaling pathway GO:2001234 104 0.018
morphogenesis of embryonic epithelium GO:0016331 159 0.018
response to extracellular stimulus GO:0009991 127 0.017
amine metabolic process GO:0009308 45 0.017
positive regulation of apoptotic process GO:0043065 217 0.017
tube closure GO:0060606 91 0.016
positive regulation of programmed cell death GO:0043068 218 0.016
positive regulation of protein phosphorylation GO:0001934 242 0.016
cellular response to oxidative stress GO:0034599 76 0.016
response to lipopolysaccharide GO:0032496 128 0.016
positive regulation of protein kinase activity GO:0045860 144 0.016
cellular protein catabolic process GO:0044257 155 0.016
positive regulation of cellular amine metabolic process GO:0033240 5 0.016
response to starvation GO:0042594 65 0.015
nadh metabolic process GO:0006734 1 0.015
cation transmembrane transport GO:0098655 266 0.015
regulation of kinase activity GO:0043549 249 0.015
positive regulation of proteolysis GO:0045862 85 0.015
cytoplasmic transport GO:0016482 234 0.015
striated muscle tissue development GO:0014706 293 0.015
nucleoside monophosphate catabolic process GO:0009125 59 0.015
organophosphate catabolic process GO:0046434 232 0.015
regulation of cellular ketone metabolic process GO:0010565 66 0.015
negative regulation of protein metabolic process GO:0051248 282 0.014
protein catabolic process GO:0030163 221 0.014
cofactor biosynthetic process GO:0051188 41 0.014
Rat
negative regulation of cell development GO:0010721 169 0.014
regulation of proteolysis GO:0030162 164 0.014
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.014
neuron apoptotic process GO:0051402 142 0.014
nucleoside phosphate catabolic process GO:1901292 222 0.014
tube formation GO:0035148 140 0.014
negative regulation of cellular amine metabolic process GO:0033239 1 0.014
fat cell differentiation GO:0045444 160 0.014
cellular response to lipid GO:0071396 145 0.014
purine containing compound catabolic process GO:0072523 213 0.014
regulation of organelle organization GO:0033043 289 0.013
regulation of cell cycle process GO:0010564 160 0.013
regulation of ion transport GO:0043269 215 0.013
response to inorganic substance GO:0010035 96 0.013
positive regulation of hydrolase activity GO:0051345 148 0.013
neural tube closure GO:0001843 90 0.013
regulation of cellular component biogenesis GO:0044087 181 0.013
action potential GO:0001508 78 0.013
mitochondrial membrane organization GO:0007006 26 0.013
negative regulation of phosphate metabolic process GO:0045936 184 0.013
positive regulation of transferase activity GO:0051347 167 0.013
regulation of reactive oxygen species metabolic process GO:2000377 40 0.012
synaptic transmission GO:0007268 329 0.012
protein import GO:0017038 101 0.012
epithelial tube formation GO:0072175 130 0.012
cellular response to molecule of bacterial origin GO:0071219 83 0.012
positive regulation of organelle organization GO:0010638 128 0.012
ribonucleoside triphosphate catabolic process GO:0009203 199 0.012
positive regulation of kinase activity GO:0033674 155 0.012
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 36 0.012
ribonucleotide catabolic process GO:0009261 208 0.012
cardiac muscle tissue development GO:0048738 130 0.012
dephosphorylation GO:0016311 129 0.012
purine ribonucleotide catabolic process GO:0009154 208 0.012
dna catabolic process endonucleolytic GO:0000737 15 0.012
inorganic cation transmembrane transport GO:0098662 207 0.012
protein processing GO:0016485 163 0.012
cellular response to organonitrogen compound GO:0071417 145 0.012
regulation of protein kinase activity GO:0045859 232 0.012
endocytosis GO:0006897 168 0.011
multicellular organismal homeostasis GO:0048871 164 0.011
skeletal system development GO:0001501 356 0.011
regulation of protein targeting GO:1903533 61 0.011
carbohydrate derivative catabolic process GO:1901136 231 0.011
gtp catabolic process GO:0006184 143 0.011
peptidyl amino acid modification GO:0018193 336 0.011
regulation of transferase activity GO:0051338 263 0.011
negative regulation of nervous system development GO:0051961 156 0.011
response to organonitrogen compound GO:0010243 246 0.011
age dependent response to oxidative stress GO:0001306 3 0.011
muscle tissue development GO:0060537 308 0.011
glycerophospholipid biosynthetic process GO:0046474 32 0.011
regulation of nucleotide metabolic process GO:0006140 169 0.011
gland development GO:0048732 330 0.011
homeostasis of number of cells GO:0048872 210 0.011
dicarboxylic acid metabolic process GO:0043648 18 0.011
cellularization GO:0007349 1 0.011
ribonucleoside catabolic process GO:0042454 206 0.010
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 57 0.010
posttranscriptional regulation of gene expression GO:0010608 155 0.010
regulation of lipid metabolic process GO:0019216 118 0.010
neural precursor cell proliferation GO:0061351 121 0.010
response to nutrient levels GO:0031667 109 0.010
positive regulation of growth GO:0045927 104 0.010
cellular nitrogen compound catabolic process GO:0044270 280 0.010
response to oxygen levels GO:0070482 62 0.010
nucleotide catabolic process GO:0009166 217 0.010
negative regulation of cellular protein metabolic process GO:0032269 247 0.010

Pdhb disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.101
inherited metabolic disorder DOID:655 0 0.101
disease of cellular proliferation DOID:14566 0 0.022
cancer DOID:162 0 0.022
organ system cancer DOID:0050686 0 0.022
disease of anatomical entity DOID:7 0 0.013
nervous system disease DOID:863 0 0.013
immune system disease DOID:2914 0 0.011