Mus musculus

40 known processes

Pdia3

protein disulfide isomerase associated 3

(Aliases: Plca,PDI-Q2,Erp,PLC[a],ERp57,Grp58,PDI,PI-PLC,ERp60,ERp61,58kDa)

Pdia3 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
response to topologically incorrect protein GO:0035966 25 0.917
er nucleus signaling pathway GO:0006984 27 0.872
cellular response to topologically incorrect protein GO:0035967 25 0.792
response to unfolded protein GO:0006986 21 0.770
endoplasmic reticulum unfolded protein response GO:0030968 19 0.714
response to endoplasmic reticulum stress GO:0034976 53 0.574
glycoprotein biosynthetic process GO:0009101 89 0.393
macromolecule glycosylation GO:0043413 55 0.383
protein n linked glycosylation GO:0006487 12 0.195
glycoprotein metabolic process GO:0009100 116 0.193
cellular protein catabolic process GO:0044257 155 0.155
posttranslational protein targeting to membrane GO:0006620 2 0.150
cotranslational protein targeting to membrane GO:0006613 2 0.132
carbohydrate derivative biosynthetic process GO:1901137 183 0.125
carbohydrate metabolic process GO:0005975 230 0.125
transmembrane transport GO:0055085 412 0.115
protein glycosylation GO:0006486 55 0.112
protein catabolic process GO:0030163 221 0.106
response to atp GO:0033198 8 0.097
protein targeting to er GO:0045047 2 0.095
lipid localization GO:0010876 126 0.095
mrna metabolic process GO:0016071 84 0.093
cellular macromolecule catabolic process GO:0044265 206 0.089
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.087
positive regulation of cell motility GO:2000147 116 0.083
maintenance of location GO:0051235 89 0.082
response to organonitrogen compound GO:0010243 246 0.078
midgut development GO:0007494 4 0.076
muscle cell differentiation GO:0042692 261 0.075
macromolecule catabolic process GO:0009057 281 0.074
glycosylation GO:0070085 62 0.070
cellular response to external stimulus GO:0071496 88 0.067
response to starvation GO:0042594 65 0.067
regulation of tube size GO:0035150 57 0.063
membrane lipid biosynthetic process GO:0046467 32 0.063
cellular response to extracellular stimulus GO:0031668 81 0.062
positive regulation of growth hormone secretion GO:0060124 3 0.062
protein transmembrane transport GO:0071806 8 0.062
amine metabolic process GO:0009308 45 0.061
cellular response to starvation GO:0009267 57 0.059
lipid storage GO:0019915 36 0.058
inorganic ion transmembrane transport GO:0098660 234 0.054
cellular response to antibiotic GO:0071236 4 0.053
fertilization GO:0009566 127 0.053
cellular response to nutrient levels GO:0031669 64 0.053
positive regulation of endocytosis GO:0045807 42 0.053
substantia nigra development GO:0021762 2 0.052
protein localization to organelle GO:0033365 185 0.051
response to organic cyclic compound GO:0014070 198 0.051
cellular lipid metabolic process GO:0044255 323 0.049
ion transmembrane transport GO:0034220 361 0.048
cellular component assembly involved in morphogenesis GO:0010927 139 0.047
positive regulation of hydrolase activity GO:0051345 148 0.046
er associated ubiquitin dependent protein catabolic process GO:0030433 10 0.045
negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 26 0.044
regulation of secretion GO:0051046 274 0.044
fatty acid metabolic process GO:0006631 121 0.044
endodermal digestive tract morphogenesis GO:0061031 4 0.043
germ cell development GO:0007281 185 0.042
cellular response to interleukin 4 GO:0071353 21 0.042
response to nutrient levels GO:0031667 109 0.041
nitrogen compound transport GO:0071705 271 0.041
monocarboxylic acid metabolic process GO:0032787 191 0.041
response to extracellular stimulus GO:0009991 127 0.041
regulation of apoptotic signaling pathway GO:2001233 197 0.041
regulation of hydrolase activity GO:0051336 246 0.038
cellular protein complex assembly GO:0043623 116 0.037
positive regulation of growth GO:0045927 104 0.037
Worm
cellular nitrogen compound catabolic process GO:0044270 280 0.037
positive regulation of cell substrate adhesion GO:0010811 47 0.037
cerebellum development GO:0021549 77 0.036
ear development GO:0043583 200 0.036
cellular amino acid metabolic process GO:0006520 103 0.036
cilium assembly GO:0042384 81 0.035
extracellular matrix organization GO:0030198 147 0.035
cation transmembrane transport GO:0098655 266 0.035
protein targeting to membrane GO:0006612 20 0.035
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.034
response to growth factor GO:0070848 198 0.034
peptidyl asparagine modification GO:0018196 1 0.034
regulation of organelle organization GO:0033043 289 0.033
spermatid development GO:0007286 108 0.033
regulation of phosphoprotein phosphatase activity GO:0043666 3 0.033
positive regulation of cell migration GO:0030335 109 0.033
positive regulation of cell death GO:0010942 224 0.033
aromatic compound catabolic process GO:0019439 286 0.033
chemotaxis GO:0006935 247 0.032
digestive tract morphogenesis GO:0048546 147 0.031
positive regulation of protein secretion GO:0050714 52 0.031
positive regulation of programmed cell death GO:0043068 218 0.031
protein n linked glycosylation via asparagine GO:0018279 1 0.031
regulation of cell motility GO:2000145 236 0.031
spermatogenesis GO:0007283 284 0.031
cell adhesion GO:0007155 329 0.030
endocytosis GO:0006897 168 0.030
compound eye development GO:0048749 1 0.029
regulation of cellular ketone metabolic process GO:0010565 66 0.029
organic acid transport GO:0015849 101 0.029
cerebellar cortex development GO:0021695 48 0.029
cellular response to organic cyclic compound GO:0071407 87 0.028
mrna processing GO:0006397 63 0.028
protein folding GO:0006457 28 0.028
Yeast Worm
apoptotic signaling pathway GO:0097190 306 0.027
positive regulation of secretion by cell GO:1903532 114 0.027
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 61 0.027
positive regulation of dendritic cell chemotaxis GO:2000510 1 0.027
establishment of synaptic vesicle localization GO:0097480 57 0.027
digestive system development GO:0055123 200 0.027
regulation of cell migration GO:0030334 219 0.026
striated muscle myosin thick filament assembly GO:0071688 1 0.026
cell chemotaxis GO:0060326 81 0.026
cellular amine metabolic process GO:0044106 44 0.026
carboxylic acid transport GO:0046942 100 0.026
response to oxygen levels GO:0070482 62 0.026
vascular process in circulatory system GO:0003018 62 0.025
lipid biosynthetic process GO:0008610 179 0.025
engulfment of apoptotic cell GO:0043652 3 0.025
positive regulation of apoptotic signaling pathway GO:2001235 95 0.025
anion transport GO:0006820 177 0.025
actin filament polymerization GO:0030041 44 0.025
positive regulation of protein modification process GO:0031401 299 0.024
response to antibiotic GO:0046677 11 0.024
embryonic epithelial tube formation GO:0001838 130 0.024
response to organophosphorus GO:0046683 22 0.024
regulation of lymphocyte activation GO:0051249 240 0.024
positive regulation of transferase activity GO:0051347 167 0.023
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.023
translation GO:0006412 93 0.023
intracellular protein transport GO:0006886 204 0.023
maintenance of protein localization in organelle GO:0072595 2 0.023
microtubule cytoskeleton organization GO:0000226 157 0.023
cellular response to biotic stimulus GO:0071216 92 0.022
regulation of endocytosis GO:0030100 69 0.022
neural tube development GO:0021915 160 0.022
negative regulation of cellular protein metabolic process GO:0032269 247 0.022
meiotic cell cycle GO:0051321 122 0.022
ribonucleoside metabolic process GO:0009119 245 0.022
divalent inorganic cation transport GO:0072511 178 0.022
regulation of cellular catabolic process GO:0031329 242 0.022
male gamete generation GO:0048232 285 0.022
actin filament organization GO:0007015 113 0.021
pigmentation GO:0043473 71 0.021
cation transport GO:0006812 399 0.020
regulation of cellular response to stress GO:0080135 159 0.020
phagocytosis GO:0006909 66 0.020
posttranscriptional regulation of gene expression GO:0010608 155 0.020
muscle tissue development GO:0060537 308 0.020
hindbrain morphogenesis GO:0021575 46 0.020
sphingolipid biosynthetic process GO:0030148 26 0.020
meiotic nuclear division GO:0007126 115 0.019
digestive tract development GO:0048565 190 0.019
muscle system process GO:0003012 141 0.019
modification dependent macromolecule catabolic process GO:0043632 133 0.019
calcium ion transport GO:0006816 159 0.019
peptidyl amino acid modification GO:0018193 336 0.019
barbed end actin filament capping GO:0051016 6 0.019
oxidation reduction process GO:0055114 342 0.019
Yeast
regulation of neuron differentiation GO:0045664 281 0.019
actin polymerization or depolymerization GO:0008154 54 0.019
chaperone mediated protein folding GO:0061077 10 0.019
establishment or maintenance of apical basal cell polarity GO:0035088 21 0.018
extracellular structure organization GO:0043062 148 0.018
transmission of nerve impulse GO:0019226 76 0.018
t cell activation GO:0042110 289 0.018
ubiquitin dependent protein catabolic process GO:0006511 129 0.018
catecholamine metabolic process GO:0006584 30 0.018
positive regulation of cell development GO:0010720 237 0.018
cellular divalent inorganic cation homeostasis GO:0072503 127 0.018
circulatory system process GO:0003013 197 0.018
cellular response to transforming growth factor beta stimulus GO:0071560 88 0.018
negative regulation of cellular response to growth factor stimulus GO:0090288 46 0.018
regulation of cell adhesion GO:0030155 154 0.017
gtp metabolic process GO:0046039 144 0.017
renal system development GO:0072001 225 0.017
negative regulation of cell development GO:0010721 169 0.017
modification dependent protein catabolic process GO:0019941 133 0.017
cytoplasmic transport GO:0016482 234 0.017
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 43 0.017
regulation of transferase activity GO:0051338 263 0.017
multi multicellular organism process GO:0044706 109 0.017
Worm
hepaticobiliary system development GO:0061008 67 0.016
cellular homeostasis GO:0019725 240 0.016
anatomical structure arrangement GO:0048532 20 0.016
spermatid differentiation GO:0048515 115 0.016
skeletal system development GO:0001501 356 0.016
rna splicing via transesterification reactions GO:0000375 43 0.016
substrate adhesion dependent cell spreading GO:0034446 30 0.016
negative regulation of protein depolymerization GO:1901880 21 0.016
protein targeting GO:0006605 143 0.016
cellular ketone metabolic process GO:0042180 84 0.016
clathrin mediated endocytosis GO:0072583 7 0.016
cellular response to cytokine stimulus GO:0071345 189 0.016
hindbrain development GO:0030902 128 0.015
organic cyclic compound catabolic process GO:1901361 295 0.015
ribonucleotide metabolic process GO:0009259 291 0.015
cellular response to lipid GO:0071396 145 0.015
protein secretion GO:0009306 111 0.015
divalent inorganic cation homeostasis GO:0072507 138 0.015
cation homeostasis GO:0055080 212 0.015
response to hypoxia GO:0001666 58 0.015
negative regulation of actin filament depolymerization GO:0030835 9 0.015
lymphocyte differentiation GO:0030098 242 0.015
developmental maturation GO:0021700 193 0.015
interleukin 8 secretion GO:0072606 3 0.015
gland development GO:0048732 330 0.015
leukocyte chemotaxis GO:0030595 69 0.015
response to purine containing compound GO:0014074 28 0.015
cellular response to toxic substance GO:0097237 7 0.015
lipid transport GO:0006869 98 0.015
negative regulation of nervous system development GO:0051961 156 0.015
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.014
positive regulation of cell activation GO:0050867 158 0.014
regulation of actin filament based process GO:0032970 99 0.014
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.014
action potential GO:0001508 78 0.014
protein refolding GO:0042026 1 0.014
l amino acid transport GO:0015807 32 0.014
multicellular organismal aging GO:0010259 24 0.014
establishment of protein localization to membrane GO:0090150 54 0.014
inorganic cation transmembrane transport GO:0098662 207 0.014
regulation of membrane potential GO:0042391 192 0.014
immunoglobulin production GO:0002377 73 0.014
receptor mediated endocytosis GO:0006898 51 0.014
regulation of cell projection organization GO:0031344 206 0.014
regulation of secretion by cell GO:1903530 249 0.014
urogenital system development GO:0001655 261 0.014
membrane organization GO:0061024 245 0.014
ribonucleoside triphosphate catabolic process GO:0009203 199 0.014
lateral inhibition GO:0046331 1 0.014
mrna splicing via spliceosome GO:0000398 43 0.014
positive regulation of nervous system development GO:0051962 221 0.014
interleukin 8 production GO:0032637 4 0.014
positive regulation of protein transport GO:0051222 93 0.014
placenta development GO:0001890 140 0.014
phenol containing compound metabolic process GO:0018958 60 0.014
homeostasis of number of cells GO:0048872 210 0.014
nuclear division GO:0000280 158 0.013
regulation of hormone levels GO:0010817 211 0.013
positive regulation of protein phosphorylation GO:0001934 242 0.013
positive regulation of cellular amine metabolic process GO:0033240 5 0.013
regulation of multi organism process GO:0043900 111 0.013
monocarboxylic acid biosynthetic process GO:0072330 61 0.013
leukocyte differentiation GO:0002521 342 0.013
glycoprotein catabolic process GO:0006516 5 0.013
regulation of vesicle mediated transport GO:0060627 139 0.013
positive regulation of cardiac muscle contraction GO:0060452 2 0.013
midbrain development GO:0030901 35 0.013
regulation of phagocytosis GO:0050764 33 0.013
oocyte construction GO:0007308 2 0.013
regulation of cellular amine metabolic process GO:0033238 20 0.013
regulation of cell substrate adhesion GO:0010810 73 0.013
cellular response to organonitrogen compound GO:0071417 145 0.013
regulation of actin cytoskeleton organization GO:0032956 84 0.013
establishment of protein localization to endoplasmic reticulum GO:0072599 2 0.013
macroautophagy GO:0016236 21 0.013
cerebellum morphogenesis GO:0021587 42 0.013
cellular response to growth factor stimulus GO:0071363 197 0.013
regulation of homeostatic process GO:0032844 182 0.013
regulation of translation GO:0006417 71 0.013
amide transport GO:0042886 138 0.013
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.013
neural nucleus development GO:0048857 22 0.013
positive regulation of fatty acid oxidation GO:0046321 4 0.013
regulation of actin polymerization or depolymerization GO:0008064 45 0.013
toxin transport GO:1901998 38 0.013
regulation of chemotaxis GO:0050920 53 0.012
insulin secretion GO:0030073 89 0.012
fat cell differentiation GO:0045444 160 0.012
regulation of cellular amino acid metabolic process GO:0006521 5 0.012
regulation of cellular component biogenesis GO:0044087 181 0.012
purine nucleoside triphosphate catabolic process GO:0009146 203 0.012
organelle disassembly GO:1903008 2 0.012
positive regulation of protein kinase activity GO:0045860 144 0.012
regulation of cellular response to growth factor stimulus GO:0090287 82 0.012
molting cycle GO:0042303 90 0.012
positive regulation of cell adhesion GO:0045785 80 0.012
nucleobase containing small molecule metabolic process GO:0055086 352 0.012
cell recognition GO:0008037 83 0.012
positive regulation of cell growth GO:0030307 33 0.012
regulation of anatomical structure size GO:0090066 178 0.012
purine nucleoside metabolic process GO:0042278 241 0.012
single fertilization GO:0007338 82 0.012
response to heat GO:0009408 27 0.012
blood circulation GO:0008015 195 0.012
multicellular organism growth GO:0035264 161 0.012
Worm
negative regulation of cellular component organization GO:0051129 194 0.012
actin cytoskeleton organization GO:0030036 220 0.012
regulation of protein depolymerization GO:1901879 26 0.012
muscle contraction GO:0006936 101 0.012
steroid metabolic process GO:0008202 119 0.012
microtubule based process GO:0007017 236 0.012
negative regulation of molecular function GO:0044092 258 0.012
neural tube formation GO:0001841 108 0.012
regulation of cell cycle GO:0051726 281 0.012
ribonucleoside triphosphate metabolic process GO:0009199 220 0.012
organophosphate catabolic process GO:0046434 232 0.012
intra golgi vesicle mediated transport GO:0006891 1 0.012
blood vessel morphogenesis GO:0048514 285 0.012
regulation of mrna processing GO:0050684 41 0.011
retina homeostasis GO:0001895 23 0.011
very long chain fatty acid biosynthetic process GO:0042761 2 0.011
heterocycle catabolic process GO:0046700 280 0.011
regulation of actin filament length GO:0030832 45 0.011
regulation of mapk cascade GO:0043408 248 0.011
calcium ion homeostasis GO:0055074 127 0.011
sequestering of metal ion GO:0051238 19 0.011
embryonic placenta development GO:0001892 98 0.011
regulation of actin filament depolymerization GO:0030834 13 0.011
establishment of organelle localization GO:0051656 122 0.011
cellular response to lipopolysaccharide GO:0071222 77 0.011
amino acid transport GO:0006865 61 0.011
cellular ion homeostasis GO:0006873 165 0.011
anatomical structure maturation GO:0071695 49 0.011
autophagy GO:0006914 45 0.011
dopaminergic neuron differentiation GO:0071542 14 0.011
response to transforming growth factor beta GO:0071559 88 0.011
notch signaling pathway GO:0007219 71 0.011
carboxylic acid biosynthetic process GO:0046394 86 0.011
rna splicing GO:0008380 54 0.011
response to estrogen GO:0043627 24 0.011
cilium morphogenesis GO:0060271 102 0.011
t cell differentiation GO:0030217 174 0.011
transforming growth factor beta receptor signaling pathway GO:0007179 71 0.011
nucleoside phosphate catabolic process GO:1901292 222 0.011
organic anion transport GO:0015711 137 0.011
regulation of ion transport GO:0043269 215 0.011
rna processing GO:0006396 105 0.011
er overload response GO:0006983 6 0.011
metencephalon development GO:0022037 89 0.010
regulation of interleukin 8 production GO:0032677 3 0.010
response to inorganic substance GO:0010035 96 0.010
regulation of cell growth GO:0001558 91 0.010
hexose metabolic process GO:0019318 98 0.010
kidney development GO:0001822 213 0.010
dephosphorylation GO:0016311 129 0.010
cellularization GO:0007349 1 0.010
negative regulation of protein complex disassembly GO:0043242 22 0.010
neural precursor cell proliferation GO:0061351 121 0.010
myosin filament organization GO:0031033 3 0.010
cytokine production GO:0001816 319 0.010
single organism cell adhesion GO:0098602 156 0.010
b cell differentiation GO:0030183 78 0.010

Pdia3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.045
inherited metabolic disorder DOID:655 0 0.045
central nervous system disease DOID:331 0 0.039
disease of anatomical entity DOID:7 0 0.039
nervous system disease DOID:863 0 0.039
carbohydrate metabolic disorder DOID:2978 0 0.016
disease of cellular proliferation DOID:14566 0 0.014
bone development disease DOID:0080006 0 0.013
bone disease DOID:0080001 0 0.013
musculoskeletal system disease DOID:17 0 0.013
connective tissue disease DOID:65 0 0.013
disease of mental health DOID:150 0 0.011
cancer DOID:162 0 0.011
neurodegenerative disease DOID:1289 0 0.011
organ system cancer DOID:0050686 0 0.010