Mus musculus

70 known processes

Phgdh

3-phosphoglycerate dehydrogenase

(Aliases: PGD,A10,3-PGDH,MGC117966,PGDH,MGC113796,SERA,PGAD,3PGDH,4930479N23)

Phgdh biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular amino acid metabolic process GO:0006520 103 0.151
cellular ketone metabolic process GO:0042180 84 0.106
purine nucleobase biosynthetic process GO:0009113 3 0.105
cellular amine metabolic process GO:0044106 44 0.067
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.059
negative regulation of protein metabolic process GO:0051248 282 0.051
mapk cascade GO:0000165 281 0.051
regulation of cellular ketone metabolic process GO:0010565 66 0.050
negative regulation of cellular protein metabolic process GO:0032269 247 0.049
cellular response to dna damage stimulus GO:0006974 207 0.046
organic cyclic compound catabolic process GO:1901361 295 0.043
male gamete generation GO:0048232 285 0.041
amine metabolic process GO:0009308 45 0.040
positive regulation of cellular amine metabolic process GO:0033240 5 0.040
peptidyl tyrosine modification GO:0018212 145 0.040
regulation of protein kinase activity GO:0045859 232 0.038
chromatin organization GO:0006325 206 0.037
regulation of kinase activity GO:0043549 249 0.037
regulation of cellular amine metabolic process GO:0033238 20 0.036
peptidyl amino acid modification GO:0018193 336 0.036
positive regulation of protein phosphorylation GO:0001934 242 0.035
nitrogen compound transport GO:0071705 271 0.034
heterocycle catabolic process GO:0046700 280 0.033
purine nucleobase metabolic process GO:0006144 4 0.032
organonitrogen compound biosynthetic process GO:1901566 192 0.032
lymphocyte mediated immunity GO:0002449 139 0.031
positive regulation of apoptotic process GO:0043065 217 0.028
small gtpase mediated signal transduction GO:0007264 97 0.027
negative regulation of protein modification process GO:0031400 163 0.026
regulation of organelle organization GO:0033043 289 0.026
anion transport GO:0006820 177 0.026
aromatic compound catabolic process GO:0019439 286 0.026
regulation of mapk cascade GO:0043408 248 0.026
organic acid transport GO:0015849 101 0.025
positive regulation of protein modification process GO:0031401 299 0.025
regulation of cellular amino acid metabolic process GO:0006521 5 0.025
leukocyte mediated immunity GO:0002443 174 0.025
purine ribonucleoside metabolic process GO:0046128 241 0.025
folic acid containing compound metabolic process GO:0006760 3 0.024
leukocyte proliferation GO:0070661 172 0.024
negative regulation of phosphorylation GO:0042326 166 0.024
carboxylic acid biosynthetic process GO:0046394 86 0.023
purine nucleotide metabolic process GO:0006163 302 0.023
ras protein signal transduction GO:0007265 77 0.023
dna recombination GO:0006310 92 0.023
nucleobase containing small molecule metabolic process GO:0055086 352 0.023
cellular homeostasis GO:0019725 240 0.023
inflammatory response GO:0006954 244 0.022
cellular amino acid biosynthetic process GO:0008652 22 0.022
cellular nitrogen compound catabolic process GO:0044270 280 0.022
cell maturation GO:0048469 127 0.022
nucleoside triphosphate catabolic process GO:0009143 205 0.022
alpha amino acid biosynthetic process GO:1901607 15 0.021
alpha amino acid metabolic process GO:1901605 59 0.021
oxidation reduction process GO:0055114 342 0.021
defense response to other organism GO:0098542 197 0.021
regulation of defense response GO:0031347 233 0.021
organophosphate catabolic process GO:0046434 232 0.020
translation GO:0006412 93 0.020
organic acid biosynthetic process GO:0016053 86 0.020
microtubule based process GO:0007017 236 0.020
transmembrane transport GO:0055085 412 0.019
negative regulation of molecular function GO:0044092 258 0.019
carbohydrate metabolic process GO:0005975 230 0.019
cytoplasmic transport GO:0016482 234 0.019
nucleoside triphosphate metabolic process GO:0009141 230 0.019
nucleoside metabolic process GO:0009116 246 0.018
regulation of cell projection organization GO:0031344 206 0.018
regulation of transferase activity GO:0051338 263 0.018
epithelial cell development GO:0002064 159 0.018
endocytosis GO:0006897 168 0.018
compound eye development GO:0048749 1 0.018
positive regulation of transferase activity GO:0051347 167 0.017
organelle fission GO:0048285 170 0.017
purine containing compound metabolic process GO:0072521 311 0.017
regulation of response to wounding GO:1903034 189 0.017
glycosyl compound catabolic process GO:1901658 206 0.017
immune effector process GO:0002252 321 0.017
peptidyl tyrosine phosphorylation GO:0018108 143 0.016
spermatogenesis GO:0007283 284 0.016
regulation of neuron differentiation GO:0045664 281 0.016
small molecule biosynthetic process GO:0044283 132 0.016
protein processing GO:0016485 163 0.016
regulation of protein serine threonine kinase activity GO:0071900 157 0.016
regulation of secretion GO:0051046 274 0.016
regulation of neuron death GO:1901214 134 0.016
glycosyl compound metabolic process GO:1901657 246 0.016
regulation of secretion by cell GO:1903530 249 0.016
positive regulation of immune effector process GO:0002699 107 0.016
carbohydrate homeostasis GO:0033500 128 0.016
regulation of cytokine production GO:0001817 266 0.016
lateral inhibition GO:0046331 1 0.016
purine ribonucleoside catabolic process GO:0046130 205 0.016
response to organonitrogen compound GO:0010243 246 0.016
chemotaxis GO:0006935 247 0.016
negative regulation of protein processing GO:0010955 79 0.016
cellular response to lipid GO:0071396 145 0.016
organonitrogen compound catabolic process GO:1901565 264 0.015
t cell activation GO:0042110 289 0.015
regulation of chromosome organization GO:0033044 83 0.015
ribose phosphate metabolic process GO:0019693 291 0.015
b cell activation GO:0042113 161 0.015
organic hydroxy compound metabolic process GO:1901615 203 0.015
ion transmembrane transport GO:0034220 361 0.015
cellular macromolecule catabolic process GO:0044265 206 0.015
positive regulation of protein kinase activity GO:0045860 144 0.014
regulation of cellular component size GO:0032535 121 0.014
morphogenesis of a branching structure GO:0001763 203 0.014
regulation of protein maturation GO:1903317 96 0.014
sensory perception GO:0007600 245 0.014
nucleoside catabolic process GO:0009164 206 0.014
mrna metabolic process GO:0016071 84 0.014
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.014
nucleotide metabolic process GO:0009117 332 0.014
ribonucleotide catabolic process GO:0009261 208 0.014
regulation of circadian sleep wake cycle sleep GO:0045187 3 0.014
monocarboxylic acid metabolic process GO:0032787 191 0.014
cell division GO:0051301 120 0.014
carbohydrate derivative catabolic process GO:1901136 231 0.014
regulation of anatomical structure size GO:0090066 178 0.014
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.014
regulation of cell activation GO:0050865 289 0.014
hatching GO:0035188 4 0.013
mitotic cell cycle process GO:1903047 159 0.013
gonad development GO:0008406 141 0.013
posttranscriptional regulation of gene expression GO:0010608 155 0.013
regulation of hormone levels GO:0010817 211 0.013
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.013
production of molecular mediator of immune response GO:0002440 103 0.013
maintenance of location GO:0051235 89 0.013
alcohol metabolic process GO:0006066 116 0.013
developmental maturation GO:0021700 193 0.013
lymphocyte proliferation GO:0046651 164 0.013
meiotic nuclear division GO:0007126 115 0.013
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.013
regulation of ion transport GO:0043269 215 0.013
germ cell development GO:0007281 185 0.013
nucleoside phosphate catabolic process GO:1901292 222 0.013
regulation of cell cycle GO:0051726 281 0.013
purine nucleoside metabolic process GO:0042278 241 0.013
positive regulation of neuron differentiation GO:0045666 141 0.012
response to light stimulus GO:0009416 135 0.012
stem cell proliferation GO:0072089 117 0.012
cell type specific apoptotic process GO:0097285 268 0.012
ribonucleoside metabolic process GO:0009119 245 0.012
purine ribonucleotide metabolic process GO:0009150 290 0.012
regulation of cell cycle process GO:0010564 160 0.012
membrane organization GO:0061024 245 0.012
negative regulation of proteolysis GO:0045861 74 0.012
carboxylic acid transport GO:0046942 100 0.012
organelle assembly GO:0070925 177 0.012
regulation of cell size GO:0008361 72 0.012
negative regulation of immune system process GO:0002683 209 0.012
regulation of cellular response to stress GO:0080135 159 0.012
nucleotide catabolic process GO:0009166 217 0.012
oocyte construction GO:0007308 2 0.011
gliogenesis GO:0042063 141 0.011
axonogenesis GO:0007409 274 0.011
negative regulation of phosphorus metabolic process GO:0010563 184 0.011
dephosphorylation GO:0016311 129 0.011
regulation of vesicle mediated transport GO:0060627 139 0.011
regulation of protein localization GO:0032880 231 0.011
apoptotic signaling pathway GO:0097190 306 0.011
nucleobase biosynthetic process GO:0046112 3 0.011
anatomical structure homeostasis GO:0060249 145 0.011
negative regulation of nervous system development GO:0051961 156 0.011
regulation of hydrolase activity GO:0051336 246 0.011
positive regulation of kinase activity GO:0033674 155 0.011
cellular chemical homeostasis GO:0055082 215 0.011
glial cell differentiation GO:0010001 131 0.011
regulation of interleukin 6 production GO:0032675 55 0.011
striated muscle tissue development GO:0014706 293 0.011
ribonucleoside triphosphate metabolic process GO:0009199 220 0.011
regulation of erk1 and erk2 cascade GO:0070372 71 0.011
regulation of engulfment of apoptotic cell GO:1901074 2 0.011
negative regulation of protein maturation GO:1903318 79 0.011
leukocyte differentiation GO:0002521 342 0.011
camera type eye development GO:0043010 266 0.011
nuclear division GO:0000280 158 0.011
nucleic acid phosphodiester bond hydrolysis GO:0090305 49 0.011
neuron apoptotic process GO:0051402 142 0.011
reactive oxygen species metabolic process GO:0072593 84 0.011
rna processing GO:0006396 105 0.011
regulation of peptidyl tyrosine phosphorylation GO:0050730 93 0.010
nuclear dna replication GO:0033260 3 0.010
positive regulation of cytokine production GO:0001819 174 0.010
cellularization GO:0007349 1 0.010
response to lipopolysaccharide GO:0032496 128 0.010
nucleoside phosphate metabolic process GO:0006753 338 0.010
coenzyme metabolic process GO:0006732 52 0.010
regulation of neuron projection development GO:0010975 169 0.010
gland development GO:0048732 330 0.010
actin cytoskeleton organization GO:0030036 220 0.010
digestive tract development GO:0048565 190 0.010
dna repair GO:0006281 107 0.010
chromatin modification GO:0016568 187 0.010
cation transport GO:0006812 399 0.010
microtubule cytoskeleton organization GO:0000226 157 0.010
response to organic cyclic compound GO:0014070 198 0.010
response to peptide GO:1901652 136 0.010
regionalization GO:0003002 337 0.010
positive regulation of programmed cell death GO:0043068 218 0.010

Phgdh disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 0 0.032
cancer DOID:162 0 0.032
disease of metabolism DOID:0014667 0 0.020
Human
inherited metabolic disorder DOID:655 0 0.020
Human
organ system cancer DOID:0050686 0 0.016
disease of anatomical entity DOID:7 0 0.013
nervous system disease DOID:863 0 0.013