Mus musculus

62 known processes

Plk4

polo-like kinase 4 (Drosophila)

(Aliases: Sak,1700028H20,Stk18,AI385771)

Plk4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
mitotic cell cycle process GO:1903047 159 0.963
Fly
nuclear division GO:0000280 158 0.945
Fly
mitotic cell cycle GO:0000278 195 0.924
Fly
meiotic cell cycle process GO:1903046 77 0.905
organelle fission GO:0048285 170 0.904
Fly
microtubule cytoskeleton organization GO:0000226 157 0.878
regulation of cell cycle process GO:0010564 160 0.822
Human Fly
dna metabolic process GO:0006259 303 0.805
microtubule based process GO:0007017 236 0.738
gonad development GO:0008406 141 0.689
meiosis i GO:0007127 60 0.687
mitotic sister chromatid segregation GO:0000070 14 0.674
mitotic chromosome condensation GO:0007076 1 0.655
meiotic cell cycle GO:0051321 122 0.623
Fly
regulation of mitotic cell cycle GO:0007346 126 0.613
mitotic nuclear division GO:0007067 48 0.597
chromosome segregation GO:0007059 48 0.565
centrosome organization GO:0051297 26 0.561
cellular response to dna damage stimulus GO:0006974 207 0.548
regulation of cell cycle GO:0051726 281 0.535
Human Fly
microtubule organizing center organization GO:0031023 28 0.522
regulation of mitosis GO:0007088 29 0.466
spindle assembly involved in mitosis GO:0090307 4 0.458
female meiotic division GO:0007143 21 0.444
dna packaging GO:0006323 30 0.426
attachment of spindle microtubules to kinetochore GO:0008608 4 0.420
spindle assembly GO:0051225 13 0.409
meiotic nuclear division GO:0007126 115 0.408
Fly
chromosome organization involved in meiosis GO:0070192 39 0.404
mitotic spindle organization GO:0007052 10 0.398
Fly
negative regulation of cell cycle GO:0045786 123 0.362
sister chromatid segregation GO:0000819 20 0.358
centrosome cycle GO:0007098 23 0.339
regulation of cell division GO:0051302 76 0.325
meiotic chromosome segregation GO:0045132 19 0.321
regulation of spindle organization GO:0090224 2 0.314
regulation of nuclear division GO:0051783 56 0.313
cell cycle checkpoint GO:0000075 47 0.291
cell division GO:0051301 120 0.287
dna recombination GO:0006310 92 0.281
dna conformation change GO:0071103 37 0.271
regulation of organelle organization GO:0033043 289 0.271
Human Fly
cellular macromolecule catabolic process GO:0044265 206 0.270
organelle assembly GO:0070925 177 0.269
negative regulation of cellular component organization GO:0051129 194 0.268
regulation of microtubule based process GO:0032886 52 0.262
Human Fly
male meiosis GO:0007140 37 0.255
Fly
synapsis GO:0007129 34 0.250
cellular protein catabolic process GO:0044257 155 0.246
female meiosis chromosome segregation GO:0016321 1 0.242
regulation of mitotic cell cycle phase transition GO:1901990 73 0.237
ribonucleoside triphosphate catabolic process GO:0009203 199 0.229
negative regulation of mitotic cell cycle phase transition GO:1901991 45 0.225
regulation of cellular catabolic process GO:0031329 242 0.216
microtubule cytoskeleton organization involved in mitosis GO:1902850 4 0.213
centromere complex assembly GO:0034508 3 0.199
male gamete generation GO:0048232 285 0.198
Fly
dna replication GO:0006260 52 0.196
aromatic compound catabolic process GO:0019439 286 0.191
double strand break repair via homologous recombination GO:0000724 21 0.190
spindle organization GO:0007051 28 0.181
Fly
nucleobase containing small molecule metabolic process GO:0055086 352 0.179
regulation of attachment of spindle microtubules to kinetochore GO:0051988 3 0.171
ribonucleoside triphosphate metabolic process GO:0009199 220 0.165
development of primary sexual characteristics GO:0045137 143 0.165
centrosome separation GO:0051299 4 0.165
regulation of meiosis i GO:0060631 7 0.163
purine nucleotide metabolic process GO:0006163 302 0.162
nucleic acid phosphodiester bond hydrolysis GO:0090305 49 0.161
negative regulation of nuclear division GO:0051784 19 0.158
mitotic cytokinesis GO:0000281 4 0.156
ubiquitin dependent protein catabolic process GO:0006511 129 0.156
nucleoside triphosphate metabolic process GO:0009141 230 0.155
double strand break repair GO:0006302 48 0.153
glycosyl compound metabolic process GO:1901657 246 0.150
ribose phosphate metabolic process GO:0019693 291 0.146
intrinsic apoptotic signaling pathway GO:0097193 132 0.143
centrosome duplication GO:0051298 16 0.143
negative regulation of cell cycle phase transition GO:1901988 48 0.134
regulation of cell cycle phase transition GO:1901987 77 0.131
positive regulation of cell cycle GO:0045787 92 0.131
Human
purine containing compound metabolic process GO:0072521 311 0.131
nucleotide metabolic process GO:0009117 332 0.129
mitotic sister chromatid separation GO:0051306 9 0.127
negative regulation of cell cycle process GO:0010948 69 0.121
negative regulation of meiotic cell cycle phase transition GO:1901994 3 0.121
negative regulation of mitotic cell cycle GO:0045930 58 0.115
response to radiation GO:0009314 165 0.111
nucleoside phosphate catabolic process GO:1901292 222 0.111
protein catabolic process GO:0030163 221 0.110
Fly
glycosyl compound catabolic process GO:1901658 206 0.110
spindle assembly involved in meiosis GO:0090306 4 0.110
spindle assembly involved in female meiosis GO:0007056 3 0.105
establishment of organelle localization GO:0051656 122 0.104
rac protein signal transduction GO:0016601 13 0.103
dna repair GO:0006281 107 0.103
negative regulation of organelle organization GO:0010639 90 0.102
peptidyl amino acid modification GO:0018193 336 0.102
maintenance of location GO:0051235 89 0.101
organic cyclic compound catabolic process GO:1901361 295 0.100
regulation of transferase activity GO:0051338 263 0.100
nucleoside phosphate metabolic process GO:0006753 338 0.096
carbohydrate derivative catabolic process GO:1901136 231 0.096
developmental maturation GO:0021700 193 0.094
purine nucleoside triphosphate catabolic process GO:0009146 203 0.094
positive regulation of mitotic cell cycle GO:0045931 41 0.093
purine nucleoside triphosphate metabolic process GO:0009144 226 0.090
cellular nitrogen compound catabolic process GO:0044270 280 0.089
ribonucleotide metabolic process GO:0009259 291 0.089
positive regulation of nucleotide catabolic process GO:0030813 88 0.086
purine ribonucleotide catabolic process GO:0009154 208 0.086
chromosome separation GO:0051304 14 0.085
regulation of purine nucleotide metabolic process GO:1900542 169 0.085
genitalia development GO:0048806 37 0.085
regulation of kinase activity GO:0043549 249 0.085
ribonucleoside catabolic process GO:0042454 206 0.085
cellular protein complex disassembly GO:0043624 36 0.084
negative regulation of cellular protein metabolic process GO:0032269 247 0.084
positive regulation of nucleotide metabolic process GO:0045981 114 0.083
regulation of cytoskeleton organization GO:0051493 122 0.082
Human Fly
regulation of nucleoside metabolic process GO:0009118 130 0.082
regulation of chromosome segregation GO:0051983 21 0.081
regulation of chromosome organization GO:0033044 83 0.080
negative regulation of meiotic cell cycle GO:0051447 14 0.079
regulation of nucleotide metabolic process GO:0006140 169 0.078
cellular response to ionizing radiation GO:0071479 11 0.077
response to light stimulus GO:0009416 135 0.074
nuclear dna replication GO:0033260 3 0.073
positive regulation of gtp catabolic process GO:0033126 85 0.073
negative regulation of proteolysis GO:0045861 74 0.071
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.070
cellular ketone metabolic process GO:0042180 84 0.070
microtubule based movement GO:0007018 84 0.069
regulation of protein complex disassembly GO:0043244 28 0.069
macromolecule catabolic process GO:0009057 281 0.069
Fly
nucleoside catabolic process GO:0009164 206 0.069
protein localization to nucleus GO:0034504 121 0.069
purine ribonucleotide metabolic process GO:0009150 290 0.068
organophosphate catabolic process GO:0046434 232 0.068
recombinational repair GO:0000725 21 0.068
regulation of microtubule cytoskeleton organization GO:0070507 37 0.067
Human Fly
purine nucleoside metabolic process GO:0042278 241 0.067
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 40 0.066
positive regulation of organelle organization GO:0010638 128 0.066
Human
nucleoside triphosphate catabolic process GO:0009143 205 0.065
purine nucleoside catabolic process GO:0006152 205 0.064
cellular amino acid metabolic process GO:0006520 103 0.063
cellular response to abiotic stimulus GO:0071214 56 0.063
reciprocal dna recombination GO:0035825 16 0.062
cellular response to radiation GO:0071478 28 0.061
regulation of protein kinase activity GO:0045859 232 0.059
cdc42 protein signal transduction GO:0032488 0 0.059
positive regulation of apoptotic process GO:0043065 217 0.059
dna replication independent nucleosome assembly GO:0006336 1 0.059
positive regulation of cellular catabolic process GO:0031331 148 0.058
purine nucleotide catabolic process GO:0006195 211 0.058
purine ribonucleoside metabolic process GO:0046128 241 0.058
dna endoreduplication GO:0042023 4 0.058
translesion synthesis GO:0019985 1 0.058
meiotic chromosome condensation GO:0010032 3 0.057
regulation of protein serine threonine kinase activity GO:0071900 157 0.057
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.056
positive regulation of hydrolase activity GO:0051345 148 0.055
histone threonine phosphorylation GO:0035405 1 0.055
positive regulation of nucleoside metabolic process GO:0045979 91 0.055
chromatin organization GO:0006325 206 0.055
microtubule anchoring GO:0034453 9 0.054
positive regulation of protein modification process GO:0031401 299 0.054
regulation of protein maturation GO:1903317 96 0.054
cellular response to organic cyclic compound GO:0071407 87 0.053
cytokinesis GO:0000910 17 0.053
non recombinational repair GO:0000726 10 0.053
organonitrogen compound catabolic process GO:1901565 264 0.052
nucleoside metabolic process GO:0009116 246 0.051
neural tube development GO:0021915 160 0.051
regulation of proteasomal protein catabolic process GO:0061136 46 0.051
oocyte maturation GO:0001556 18 0.051
meiotic cytokinesis GO:0033206 5 0.050
regulation of cellular amine metabolic process GO:0033238 20 0.050
amine metabolic process GO:0009308 45 0.049
chromatin remodeling at centromere GO:0031055 2 0.049
covalent chromatin modification GO:0016569 163 0.049
chromatin modification GO:0016568 187 0.048
negative regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032435 15 0.047
synaptonemal complex assembly GO:0007130 13 0.046
negative regulation of protein phosphorylation GO:0001933 126 0.045
regulation of cellular ketone metabolic process GO:0010565 66 0.045
receptor mediated endocytosis GO:0006898 51 0.045
protein depolymerization GO:0051261 34 0.044
heterochromatin organization GO:0070828 4 0.043
protein complex disassembly GO:0043241 40 0.043
cellular response to organonitrogen compound GO:0071417 145 0.042
cellular amine metabolic process GO:0044106 44 0.042
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.042
negative regulation of microtubule polymerization or depolymerization GO:0031111 15 0.041
negative regulation of protein metabolic process GO:0051248 282 0.041
ribonucleotide catabolic process GO:0009261 208 0.041
regulation of microtubule depolymerization GO:0031114 13 0.040
regulation of protein localization GO:0032880 231 0.040
ras protein signal transduction GO:0007265 77 0.040
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 16 0.039
dna catabolic process endonucleolytic GO:0000737 15 0.039
regulation of dna replication GO:0006275 17 0.039
negative regulation of cell division GO:0051782 24 0.039
positive regulation of purine nucleotide catabolic process GO:0033123 88 0.039
proteasomal protein catabolic process GO:0010498 98 0.039
muscle cell differentiation GO:0042692 261 0.038
negative regulation of phosphate metabolic process GO:0045936 184 0.038
organelle localization GO:0051640 179 0.038
purine ribonucleoside catabolic process GO:0046130 205 0.038
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.038
dna catabolic process GO:0006308 19 0.037
homeostasis of number of cells GO:0048872 210 0.037
digestive tract morphogenesis GO:0048546 147 0.037
response to oxygen levels GO:0070482 62 0.036
cell fate commitment GO:0045165 210 0.036
regulation of double strand break repair via homologous recombination GO:0010569 2 0.035
positive regulation of transferase activity GO:0051347 167 0.035
cellular response to inorganic substance GO:0071241 37 0.035
regulation of cellular amino acid metabolic process GO:0006521 5 0.035
dna dependent dna replication GO:0006261 24 0.035
regulation of hydrolase activity GO:0051336 246 0.034
dna ligation GO:0006266 3 0.034
regulation of cellular response to stress GO:0080135 159 0.033
histone phosphorylation GO:0016572 9 0.033
positive regulation of protein kinase activity GO:0045860 144 0.032
response to uv GO:0009411 44 0.032
cellular response to lipid GO:0071396 145 0.032
single fertilization GO:0007338 82 0.032
negative regulation of cellular protein catabolic process GO:1903363 22 0.031
regulation of binding GO:0051098 111 0.031
apoptotic signaling pathway GO:0097190 306 0.031
positive regulation of kinase activity GO:0033674 155 0.031
response to inorganic substance GO:0010035 96 0.030
purine containing compound catabolic process GO:0072523 213 0.030
regulation of chromatin binding GO:0035561 7 0.030
positive regulation of cell cycle process GO:0090068 61 0.030
Human
positive regulation of gtpase activity GO:0043547 85 0.030
response to oxidative stress GO:0006979 123 0.030
mitotic centrosome separation GO:0007100 4 0.029
modification dependent protein catabolic process GO:0019941 133 0.029
cell cycle g2 m phase transition GO:0044839 20 0.029
regulation of purine nucleotide catabolic process GO:0033121 122 0.029
regulation of cellular protein catabolic process GO:1903362 61 0.029
chromosome condensation GO:0030261 10 0.028
cellular response to acid chemical GO:0071229 68 0.028
rna interference GO:0016246 2 0.028
modification dependent macromolecule catabolic process GO:0043632 133 0.028
regulation of protein depolymerization GO:1901879 26 0.028
macromolecule methylation GO:0043414 120 0.028
spindle assembly involved in female meiosis i GO:0007057 2 0.028
rho protein signal transduction GO:0007266 32 0.027
negative regulation of intracellular signal transduction GO:1902532 167 0.027
female gamete generation GO:0007292 74 0.027
meiotic dna double strand break formation GO:0042138 3 0.027
mesodermal cell migration GO:0008078 4 0.027
negative regulation of protein depolymerization GO:1901880 21 0.027
cell maturation GO:0048469 127 0.026
small gtpase mediated signal transduction GO:0007264 97 0.026
female meiosis i GO:0007144 7 0.026
positive regulation of cell division GO:0051781 31 0.026
negative regulation of protein modification process GO:0031400 163 0.026
negative regulation of molecular function GO:0044092 258 0.026
response to decreased oxygen levels GO:0036293 59 0.026
metaphase plate congression GO:0051310 2 0.026
regulation of dna dependent dna replication GO:0090329 8 0.025
neural tube closure GO:0001843 90 0.025
cell cycle g1 s phase transition GO:0044843 57 0.025
regulation of mitotic sister chromatid segregation GO:0033047 12 0.025
establishment or maintenance of cell polarity GO:0007163 86 0.025
response to organic cyclic compound GO:0014070 198 0.025
regulation of dna recombination GO:0000018 34 0.025
male meiosis i GO:0007141 16 0.024
regulation of histone modification GO:0031056 56 0.024
spermatogenesis GO:0007283 284 0.024
Fly
multi multicellular organism process GO:0044706 109 0.024
endocytosis GO:0006897 168 0.024
regulation of rho gtpase activity GO:0032319 58 0.024
ribonucleoside metabolic process GO:0009119 245 0.024
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.024
mitotic spindle assembly checkpoint GO:0007094 7 0.024
nucleotide catabolic process GO:0009166 217 0.024
histone acetylation GO:0016573 41 0.023
positive regulation of cellular amine metabolic process GO:0033240 5 0.023
response to organonitrogen compound GO:0010243 246 0.023
protein import into nucleus GO:0006606 95 0.023
atp catabolic process GO:0006200 55 0.023
mitotic recombination GO:0006312 3 0.022
spindle checkpoint GO:0031577 12 0.022
protein localization to organelle GO:0033365 185 0.022
germ cell development GO:0007281 185 0.022
Fly
neural tube formation GO:0001841 108 0.022
cellular response to hormone stimulus GO:0032870 150 0.022
regulation of cell projection organization GO:0031344 206 0.022
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.021
protein maturation GO:0051604 176 0.021
mitotic g2 dna damage checkpoint GO:0007095 8 0.021
organism emergence from protective structure GO:0071684 4 0.021
negative regulation of protein complex disassembly GO:0043242 22 0.020
purine nucleoside monophosphate metabolic process GO:0009126 81 0.020
negative regulation of sister chromatid segregation GO:0033046 7 0.020
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.020
gtp metabolic process GO:0046039 144 0.019
negative regulation of mitosis GO:0045839 10 0.019
regulation of response to dna damage stimulus GO:2001020 34 0.019
microtubule depolymerization GO:0007019 15 0.019
response to hypoxia GO:0001666 58 0.019
neural precursor cell proliferation GO:0061351 121 0.019
reciprocal meiotic recombination GO:0007131 16 0.018
negative regulation of phosphorylation GO:0042326 166 0.018
meiotic spindle organization GO:0000212 9 0.018
protein modification by small protein conjugation or removal GO:0070647 207 0.018
regulation of protein processing GO:0070613 96 0.018
regulation of microtubule polymerization or depolymerization GO:0031110 20 0.018
protein import GO:0017038 101 0.018
digestive system development GO:0055123 200 0.018
negative regulation of wnt signaling pathway GO:0030178 73 0.018
positive regulation of cell cycle phase transition GO:1901989 17 0.018
positive regulation of cytoskeleton organization GO:0051495 49 0.018
Human
cellularization GO:0007349 1 0.018
regulation of gtp catabolic process GO:0033124 113 0.018
regulation of lymphocyte activation GO:0051249 240 0.018
mitotic cell cycle embryonic GO:0045448 5 0.018
Fly
regulation of chromatin modification GO:1903308 57 0.018
wnt signaling pathway GO:0016055 188 0.017
microtubule polymerization or depolymerization GO:0031109 26 0.017
inner cell mass cell proliferation GO:0001833 15 0.017
kinetochore organization GO:0051383 2 0.017
negative regulation of phosphorus metabolic process GO:0010563 184 0.017
nucleoside monophosphate metabolic process GO:0009123 85 0.017
protein oligomerization GO:0051259 67 0.017
mitotic cell cycle checkpoint GO:0007093 31 0.017
positive regulation of nervous system development GO:0051962 221 0.017
actin cytoskeleton organization GO:0030036 220 0.017
single organism nuclear import GO:1902593 95 0.017
regulation of mitotic sister chromatid separation GO:0010965 12 0.017
heterocycle catabolic process GO:0046700 280 0.017
guanosine containing compound metabolic process GO:1901068 144 0.016
regulation of apoptotic signaling pathway GO:2001233 197 0.016
regulation of intracellular protein transport GO:0033157 82 0.016
maintenance of location in cell GO:0051651 24 0.016
positive regulation of intracellular transport GO:0032388 70 0.016
macromolecular complex disassembly GO:0032984 43 0.016
regulation of response to wounding GO:1903034 189 0.016
peptidyl lysine modification GO:0018205 77 0.016
cellular response to decreased oxygen levels GO:0036294 18 0.016
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 57 0.016
regulation of neuron projection development GO:0010975 169 0.016
axonogenesis GO:0007409 274 0.016
regulation of ras gtpase activity GO:0032318 88 0.015
neuron migration GO:0001764 122 0.015
posttranscriptional regulation of gene expression GO:0010608 155 0.015
Fly
muscle tissue development GO:0060537 308 0.015
regulation of cellular component size GO:0032535 121 0.015
negative regulation of mitotic sister chromatid segregation GO:0033048 7 0.015
oocyte differentiation GO:0009994 35 0.015
ribonucleoside monophosphate metabolic process GO:0009161 80 0.015
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 56 0.015
cell type specific apoptotic process GO:0097285 268 0.015
g1 s transition of mitotic cell cycle GO:0000082 57 0.015
meiosis ii GO:0007135 7 0.015
dendrite development GO:0016358 115 0.015
dna biosynthetic process GO:0071897 22 0.015
negative regulation of proteolysis involved in cellular protein catabolic process GO:1903051 22 0.015
cohesin localization to chromatin GO:0071921 1 0.015
leukocyte apoptotic process GO:0071887 71 0.015
gene silencing by rna GO:0031047 19 0.014
negative regulation of chromosome organization GO:2001251 30 0.014
negative regulation of protein catabolic process GO:0042177 36 0.014
positive regulation of meiotic cell cycle GO:0051446 15 0.014
organophosphate biosynthetic process GO:0090407 122 0.014
protein secretion GO:0009306 111 0.014
response to metal ion GO:0010038 47 0.014
engulfment of apoptotic cell GO:0043652 3 0.014
regulation of wnt signaling pathway GO:0030111 123 0.014
cytokinetic process GO:0032506 2 0.014
negative regulation of protein maturation GO:1903318 79 0.014
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.014
striated muscle cell development GO:0055002 125 0.013
protein modification by small protein conjugation GO:0032446 187 0.013
regulation of chromatin organization GO:1902275 57 0.013
positive regulation of chromatin modification GO:1903310 28 0.013
regulation of actin filament based process GO:0032970 99 0.013
leukocyte proliferation GO:0070661 172 0.013
regulation of cytokinesis GO:0032465 5 0.013
mesoderm morphogenesis GO:0048332 64 0.013
regulation of cell cycle g2 m phase transition GO:1902749 10 0.013
body morphogenesis GO:0010171 45 0.013
blastocyst development GO:0001824 80 0.013
regulation of rho protein signal transduction GO:0035023 71 0.013
endomembrane system organization GO:0010256 147 0.013
guanosine containing compound catabolic process GO:1901069 144 0.013
regulation of neuron differentiation GO:0045664 281 0.013
actomyosin structure organization GO:0031032 56 0.013
wound healing GO:0042060 157 0.012
regulation of circadian rhythm GO:0042752 58 0.012
regulation of cell activation GO:0050865 289 0.012
organic hydroxy compound metabolic process GO:1901615 203 0.012
response to inactivity GO:0014854 4 0.012
purine ribonucleoside monophosphate catabolic process GO:0009169 57 0.012
positive regulation of cell death GO:0010942 224 0.012
posttranscriptional gene silencing GO:0016441 10 0.012
meiotic cell cycle checkpoint GO:0033313 2 0.012
regulation of metaphase anaphase transition of cell cycle GO:1902099 9 0.012
dna modification GO:0006304 50 0.012
atp metabolic process GO:0046034 75 0.012
nuclear import GO:0051170 95 0.012
asymmetric neuroblast division GO:0055059 1 0.012
regulation of systemic arterial blood pressure by vasopressin GO:0001992 3 0.012
regulation of protein localization to nucleus GO:1900180 60 0.012
positive regulation of cell development GO:0010720 237 0.012
intracellular protein transport GO:0006886 204 0.012
gtp catabolic process GO:0006184 143 0.012
internal protein amino acid acetylation GO:0006475 42 0.012
dephosphorylation GO:0016311 129 0.012
membrane organization GO:0061024 245 0.012
establishment of protein localization to organelle GO:0072594 118 0.011
cellular lipid metabolic process GO:0044255 323 0.011
protein acylation GO:0043543 64 0.011
protein homooligomerization GO:0051260 43 0.011
negative regulation of mitotic metaphase anaphase transition GO:0045841 7 0.011
positive regulation of protein localization to nucleus GO:1900182 30 0.011
protein ubiquitination GO:0016567 171 0.011
response to ionizing radiation GO:0010212 42 0.011
regulation of embryonic development GO:0045995 71 0.011
regulation of mitotic spindle organization GO:0060236 2 0.011
regulation of system process GO:0044057 200 0.011
spermatid differentiation GO:0048515 115 0.011
Fly
regulation of rac protein signal transduction GO:0035020 19 0.011
regulation of histone acetylation GO:0035065 19 0.011
anatomical structure homeostasis GO:0060249 145 0.011
nucleoside monophosphate catabolic process GO:0009125 59 0.011
regulation of lipid metabolic process GO:0019216 118 0.011
negative regulation of cytoskeleton organization GO:0051494 36 0.011
microtubule sliding GO:0051012 1 0.011
positive regulation of nfat protein import into nucleus GO:0051533 1 0.011
embryonic epithelial tube formation GO:0001838 130 0.011
ossification GO:0001503 216 0.011
mapk cascade GO:0000165 281 0.010
blood vessel morphogenesis GO:0048514 285 0.010
gastrulation GO:0007369 116 0.010
cellular response to oxygen levels GO:0071453 20 0.010
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.010
positive regulation of programmed cell death GO:0043068 218 0.010
response to alkaloid GO:0043279 34 0.010
muscle cell development GO:0055001 133 0.010
peptidyl serine modification GO:0018209 83 0.010
positive regulation of protein phosphorylation GO:0001934 242 0.010
protein localization to chromosome centromeric region GO:0071459 1 0.010
t cell differentiation GO:0030217 174 0.010
regulation of ras protein signal transduction GO:0046578 114 0.010
dna integrity checkpoint GO:0031570 28 0.010

Plk4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
physical disorder DOID:0080015 0 0.012
disease of cellular proliferation DOID:14566 0 0.012