Mus musculus

0 known processes

Pnpla8

patatin-like phospholipase domain containing 8

(Aliases: 1200006O19Rik,AI467579,MGC150064,Ipla2(gamma))

Pnpla8 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of cellular catabolic process GO:0031329 242 0.151
establishment of protein localization to peroxisome GO:0072663 4 0.136
cellular amino acid metabolic process GO:0006520 103 0.119
guanosine containing compound metabolic process GO:1901068 144 0.112
organic cyclic compound catabolic process GO:1901361 295 0.105
protein localization to peroxisome GO:0072662 4 0.100
nucleotide metabolic process GO:0009117 332 0.093
nucleobase containing small molecule metabolic process GO:0055086 352 0.081
cellular ketone metabolic process GO:0042180 84 0.079
small gtpase mediated signal transduction GO:0007264 97 0.077
glycosyl compound metabolic process GO:1901657 246 0.076
ribonucleoside catabolic process GO:0042454 206 0.076
protein catabolic process GO:0030163 221 0.075
response to oxidative stress GO:0006979 123 0.074
ras protein signal transduction GO:0007265 77 0.072
ribose phosphate metabolic process GO:0019693 291 0.068
ribonucleoside triphosphate catabolic process GO:0009203 199 0.067
purine ribonucleoside metabolic process GO:0046128 241 0.066
peroxisome organization GO:0007031 7 0.063
nucleoside phosphate metabolic process GO:0006753 338 0.062
ribonucleoside triphosphate metabolic process GO:0009199 220 0.062
cellular macromolecule catabolic process GO:0044265 206 0.059
ribonucleotide metabolic process GO:0009259 291 0.058
aromatic compound catabolic process GO:0019439 286 0.057
glycerophospholipid metabolic process GO:0006650 71 0.056
Human
purine ribonucleotide catabolic process GO:0009154 208 0.055
regulation of cellular response to stress GO:0080135 159 0.055
ribonucleotide catabolic process GO:0009261 208 0.053
negative regulation of protein metabolic process GO:0051248 282 0.052
purine ribonucleoside catabolic process GO:0046130 205 0.050
organonitrogen compound catabolic process GO:1901565 264 0.050
Human
ribonucleoside metabolic process GO:0009119 245 0.049
regulation of cellular ketone metabolic process GO:0010565 66 0.048
peroxisomal transport GO:0043574 4 0.048
guanosine containing compound catabolic process GO:1901069 144 0.048
negative regulation of cellular component organization GO:0051129 194 0.048
anion transport GO:0006820 177 0.046
Human
carboxylic acid catabolic process GO:0046395 51 0.046
response to nutrient levels GO:0031667 109 0.045
cellular protein catabolic process GO:0044257 155 0.044
amine metabolic process GO:0009308 45 0.044
Human
heterocycle catabolic process GO:0046700 280 0.043
purine nucleoside triphosphate catabolic process GO:0009146 203 0.042
cellular response to organonitrogen compound GO:0071417 145 0.042
cellular nitrogen compound catabolic process GO:0044270 280 0.042
negative regulation of intracellular signal transduction GO:1902532 167 0.041
nucleoside triphosphate metabolic process GO:0009141 230 0.040
response to radiation GO:0009314 165 0.040
organic anion transport GO:0015711 137 0.040
Human
ubiquitin dependent protein catabolic process via the multivesicular body sorting pathway GO:0043162 3 0.039
autophagy GO:0006914 45 0.039
organic hydroxy compound metabolic process GO:1901615 203 0.038
Human
purine ribonucleotide metabolic process GO:0009150 290 0.038
macromolecule catabolic process GO:0009057 281 0.037
nucleoside metabolic process GO:0009116 246 0.037
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.036
negative regulation of phosphorus metabolic process GO:0010563 184 0.036
purine containing compound catabolic process GO:0072523 213 0.035
chromosome organization involved in meiosis GO:0070192 39 0.035
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.035
membrane organization GO:0061024 245 0.034
organophosphate catabolic process GO:0046434 232 0.034
Human
purine nucleoside triphosphate metabolic process GO:0009144 226 0.034
small molecule biosynthetic process GO:0044283 132 0.034
Human
intracellular protein transport GO:0006886 204 0.033
protein targeting GO:0006605 143 0.033
negative regulation of cellular protein metabolic process GO:0032269 247 0.033
nitrogen compound transport GO:0071705 271 0.033
wnt signaling pathway GO:0016055 188 0.032
oxidation reduction process GO:0055114 342 0.032
action potential GO:0001508 78 0.031
spermatogenesis GO:0007283 284 0.031
gtp metabolic process GO:0046039 144 0.031
organic acid biosynthetic process GO:0016053 86 0.031
Human
multicellular organism growth GO:0035264 161 0.031
cellular response to hormone stimulus GO:0032870 150 0.031
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.031
lipid biosynthetic process GO:0008610 179 0.031
Human
protein targeting to peroxisome GO:0006625 4 0.030
purine nucleoside metabolic process GO:0042278 241 0.030
protein ubiquitination GO:0016567 171 0.030
response to light stimulus GO:0009416 135 0.030
regulation of organelle organization GO:0033043 289 0.030
carbohydrate derivative catabolic process GO:1901136 231 0.029
translation GO:0006412 93 0.029
mitochondrion organization GO:0007005 134 0.029
regulation of purine nucleotide metabolic process GO:1900542 169 0.029
fatty acid metabolic process GO:0006631 121 0.029
Human
purine nucleotide metabolic process GO:0006163 302 0.028
negative regulation of phosphate metabolic process GO:0045936 184 0.028
regulation of neuron projection development GO:0010975 169 0.028
posttranscriptional regulation of gene expression GO:0010608 155 0.028
cofactor metabolic process GO:0051186 80 0.028
transmembrane transport GO:0055085 412 0.028
regulation of neuron differentiation GO:0045664 281 0.028
cell type specific apoptotic process GO:0097285 268 0.028
negative regulation of immune system process GO:0002683 209 0.028
response to organonitrogen compound GO:0010243 246 0.027
nucleoside catabolic process GO:0009164 206 0.027
regulation of cellular amine metabolic process GO:0033238 20 0.027
i kappab kinase nf kappab signaling GO:0007249 85 0.027
rho protein signal transduction GO:0007266 32 0.027
organelle fission GO:0048285 170 0.027
response to starvation GO:0042594 65 0.027
purine containing compound metabolic process GO:0072521 311 0.026
nucleoside phosphate catabolic process GO:1901292 222 0.026
regulation of cellular component biogenesis GO:0044087 181 0.026
reactive oxygen species metabolic process GO:0072593 84 0.026
regulation of purine nucleotide catabolic process GO:0033121 122 0.026
regulation of lipid metabolic process GO:0019216 118 0.026
meiotic cell cycle process GO:1903046 77 0.026
small molecule catabolic process GO:0044282 71 0.026
Human
axonogenesis GO:0007409 274 0.026
meiotic cell cycle GO:0051321 122 0.026
nucleotide catabolic process GO:0009166 217 0.026
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.026
nuclear division GO:0000280 158 0.026
sterol metabolic process GO:0016125 58 0.026
meiotic nuclear division GO:0007126 115 0.025
golgi to endosome transport GO:0006895 3 0.025
establishment of protein localization to organelle GO:0072594 118 0.025
activation of immune response GO:0002253 138 0.025
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.024
germ cell development GO:0007281 185 0.024
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.024
cell growth GO:0016049 130 0.024
regulation of nucleotide catabolic process GO:0030811 122 0.024
purine nucleoside catabolic process GO:0006152 205 0.024
regulation of membrane potential GO:0042391 192 0.024
cation transport GO:0006812 399 0.023
regulation of transferase activity GO:0051338 263 0.023
cellular amine metabolic process GO:0044106 44 0.023
Human
regulation of nucleotide metabolic process GO:0006140 169 0.023
synapsis GO:0007129 34 0.023
phospholipid metabolic process GO:0006644 87 0.023
Human
regulation of nucleoside metabolic process GO:0009118 130 0.023
negative regulation of protein modification process GO:0031400 163 0.023
positive regulation of cellular amine metabolic process GO:0033240 5 0.023
regulation of ras gtpase activity GO:0032318 88 0.023
establishment of protein localization to vacuole GO:0072666 4 0.023
dendrite development GO:0016358 115 0.022
steroid metabolic process GO:0008202 119 0.022
response to inorganic substance GO:0010035 96 0.022
regulation of defense response GO:0031347 233 0.022
canonical wnt signaling pathway GO:0060070 130 0.022
nucleoside triphosphate catabolic process GO:0009143 205 0.022
positive regulation of ras gtpase activity GO:0032320 65 0.022
regulation of cellular amino acid metabolic process GO:0006521 5 0.022
regulation of intrinsic apoptotic signaling pathway GO:2001242 61 0.021
lipid localization GO:0010876 126 0.021
Human
protein localization to organelle GO:0033365 185 0.021
regulation of cell projection organization GO:0031344 206 0.021
organophosphate biosynthetic process GO:0090407 122 0.021
positive regulation of nucleotide catabolic process GO:0030813 88 0.021
mitotic cell cycle process GO:1903047 159 0.021
synapse organization GO:0050808 125 0.021
cellular response to growth factor stimulus GO:0071363 197 0.021
response to peptide hormone GO:0043434 127 0.021
defense response to other organism GO:0098542 197 0.020
forebrain development GO:0030900 302 0.020
microtubule based process GO:0007017 236 0.020
organelle localization GO:0051640 179 0.020
response to extracellular stimulus GO:0009991 127 0.020
regulation of anatomical structure size GO:0090066 178 0.020
positive regulation of cell motility GO:2000147 116 0.020
positive regulation of protein modification process GO:0031401 299 0.020
synaptonemal complex organization GO:0070193 15 0.019
mapk cascade GO:0000165 281 0.019
protein modification by small protein conjugation or removal GO:0070647 207 0.019
t cell activation GO:0042110 289 0.019
female gamete generation GO:0007292 74 0.019
monocarboxylic acid metabolic process GO:0032787 191 0.019
Human
alcohol biosynthetic process GO:0046165 43 0.019
positive regulation of purine nucleotide catabolic process GO:0033123 88 0.019
multicellular organismal signaling GO:0035637 91 0.019
purine nucleotide catabolic process GO:0006195 211 0.019
cellular homeostasis GO:0019725 240 0.018
mitochondrion degradation GO:0000422 3 0.018
response to peptide GO:1901652 136 0.018
camera type eye development GO:0043010 266 0.018
negative regulation of phosphorylation GO:0042326 166 0.018
organic hydroxy compound biosynthetic process GO:1901617 77 0.018
regulation of apoptotic signaling pathway GO:2001233 197 0.018
positive regulation of neuron differentiation GO:0045666 141 0.018
regulation of gtp catabolic process GO:0033124 113 0.018
actin cytoskeleton organization GO:0030036 220 0.018
organonitrogen compound biosynthetic process GO:1901566 192 0.018
regulation of lymphocyte activation GO:0051249 240 0.018
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.018
maintenance of location GO:0051235 89 0.018
female meiosis chromosome segregation GO:0016321 1 0.018
protein oligomerization GO:0051259 67 0.017
response to growth factor GO:0070848 198 0.017
monocarboxylic acid biosynthetic process GO:0072330 61 0.017
Human
positive regulation of nervous system development GO:0051962 221 0.017
alcohol metabolic process GO:0006066 116 0.017
Human
ossification GO:0001503 216 0.017
organic acid transport GO:0015849 101 0.017
Human
positive regulation of gtpase activity GO:0043547 85 0.017
transmission of nerve impulse GO:0019226 76 0.017
positive regulation of nucleotide metabolic process GO:0045981 114 0.017
ubiquitin dependent protein catabolic process GO:0006511 129 0.017
regulation of cell migration GO:0030334 219 0.017
localization within membrane GO:0051668 4 0.017
cation homeostasis GO:0055080 212 0.017
cytoplasmic transport GO:0016482 234 0.017
protein localization to vacuole GO:0072665 4 0.017
regulation of intracellular transport GO:0032386 159 0.016
regulation of translation GO:0006417 71 0.016
positive regulation of nucleoside metabolic process GO:0045979 91 0.016
cellular response to peptide GO:1901653 92 0.016
fat cell differentiation GO:0045444 160 0.016
regulation of synaptic plasticity GO:0048167 87 0.016
fatty acid alpha oxidation GO:0001561 2 0.016
regulation of reactive oxygen species metabolic process GO:2000377 40 0.016
negative regulation of protein phosphorylation GO:0001933 126 0.016
regulation of cell motility GO:2000145 236 0.016
regulation of neuron death GO:1901214 134 0.016
protein targeting to vacuole GO:0006623 3 0.016
negative regulation of neuron death GO:1901215 98 0.016
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.016
cellular response to transforming growth factor beta stimulus GO:0071560 88 0.016
positive regulation of hydrolase activity GO:0051345 148 0.016
regulation of mapk cascade GO:0043408 248 0.015
lipid transport GO:0006869 98 0.015
Human
endocytosis GO:0006897 168 0.015
neuron death GO:0070997 154 0.015
regulation of kinase activity GO:0043549 249 0.015
gtp catabolic process GO:0006184 143 0.015
negative regulation of ras protein signal transduction GO:0046580 18 0.015
neuronal action potential GO:0019228 54 0.015
regulation of ras protein signal transduction GO:0046578 114 0.015
cellular response to cytokine stimulus GO:0071345 189 0.015
proteasomal protein catabolic process GO:0010498 98 0.015
cofactor biosynthetic process GO:0051188 41 0.015
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.015
fatty acid oxidation GO:0019395 28 0.015
regulation of secretion by cell GO:1903530 249 0.015
anatomical structure homeostasis GO:0060249 145 0.015
carboxylic acid biosynthetic process GO:0046394 86 0.015
Human
glycerolipid metabolic process GO:0046486 122 0.015
Human
response to organic cyclic compound GO:0014070 198 0.014
cellularization GO:0007349 1 0.014
response to uv GO:0009411 44 0.014
regulation of secretion GO:0051046 274 0.014
male gamete generation GO:0048232 285 0.014
glycosyl compound catabolic process GO:1901658 206 0.014
pyrimidine containing compound catabolic process GO:0072529 3 0.014
developmental maturation GO:0021700 193 0.014
regulation of ossification GO:0030278 112 0.014
negative regulation of cellular response to growth factor stimulus GO:0090288 46 0.014
leukocyte differentiation GO:0002521 342 0.014
chromatin organization GO:0006325 206 0.014
response to drug GO:0042493 75 0.014
modification dependent protein catabolic process GO:0019941 133 0.014
regulation of neuron apoptotic process GO:0043523 122 0.014
sensory perception GO:0007600 245 0.014
adaptive immune response GO:0002250 155 0.014
adult behavior GO:0030534 135 0.014
mitotic nuclear division GO:0007067 48 0.014
mitotic cell cycle GO:0000278 195 0.014
retrograde transport endosome to golgi GO:0042147 2 0.014
cellular lipid metabolic process GO:0044255 323 0.013
Human
coenzyme biosynthetic process GO:0009108 23 0.013
brown fat cell differentiation GO:0050873 36 0.013
ion transmembrane transport GO:0034220 361 0.013
negative regulation of cell cycle GO:0045786 123 0.013
regulation of innate immune response GO:0045088 91 0.013
response to endoplasmic reticulum stress GO:0034976 53 0.013
negative regulation of mapk cascade GO:0043409 65 0.013
cellular response to nutrient levels GO:0031669 64 0.013
regulation of protein catabolic process GO:0042176 108 0.013
cellular response to insulin stimulus GO:0032869 78 0.013
immune effector process GO:0002252 321 0.013
apoptotic signaling pathway GO:0097190 306 0.013
regulation of t cell proliferation GO:0042129 92 0.013
chiasma assembly GO:0051026 6 0.013
regulation of cellular response to growth factor stimulus GO:0090287 82 0.013
nucleotide biosynthetic process GO:0009165 78 0.013
chromosome segregation GO:0007059 48 0.013
regulation of rho protein signal transduction GO:0035023 71 0.013
membrane fusion GO:0061025 38 0.013
regulation of cellular component size GO:0032535 121 0.013
response to acid chemical GO:0001101 111 0.013
tissue homeostasis GO:0001894 115 0.013
stem cell development GO:0048864 219 0.013
regulation of cell cycle process GO:0010564 160 0.013
response to transforming growth factor beta GO:0071559 88 0.013
early endosome to late endosome transport GO:0045022 2 0.013
skeletal system morphogenesis GO:0048705 203 0.013
cellular response to lipid GO:0071396 145 0.013
negative regulation of molecular function GO:0044092 258 0.013
lateral inhibition GO:0046331 1 0.013
positive regulation of transferase activity GO:0051347 167 0.012
carbohydrate derivative biosynthetic process GO:1901137 183 0.012
cytokine production GO:0001816 319 0.012
myeloid leukocyte differentiation GO:0002573 119 0.012
protein import GO:0017038 101 0.012
immune response regulating signaling pathway GO:0002764 125 0.012
compound eye development GO:0048749 1 0.012
regulation of proteolysis GO:0030162 164 0.012
lipoprotein metabolic process GO:0042157 43 0.012
lipid modification GO:0030258 65 0.012
chemotaxis GO:0006935 247 0.012
positive regulation of programmed cell death GO:0043068 218 0.012
translational initiation GO:0006413 24 0.012
nucleoside phosphate biosynthetic process GO:1901293 79 0.012
cellular response to biotic stimulus GO:0071216 92 0.012
muscle tissue development GO:0060537 308 0.012
cellular response to peptide hormone stimulus GO:0071375 92 0.012
regulation of protein kinase activity GO:0045859 232 0.012
phosphatidylethanolamine biosynthetic process GO:0006646 2 0.012
regulation of autophagy GO:0010506 30 0.012
locomotory behavior GO:0007626 195 0.012
immune response activating signal transduction GO:0002757 116 0.012
regulation of fatty acid metabolic process GO:0019217 28 0.012
ribonucleoprotein complex localization GO:0071166 1 0.012
response to insulin GO:0032868 100 0.012
stress activated protein kinase signaling cascade GO:0031098 81 0.012
regulation of cellular protein catabolic process GO:1903362 61 0.012
regulation of lymphocyte anergy GO:0002911 4 0.012
cellular chemical homeostasis GO:0055082 215 0.012
regulation of vesicle mediated transport GO:0060627 139 0.011
blood circulation GO:0008015 195 0.011
regulation of protein serine threonine kinase activity GO:0071900 157 0.011
regionalization GO:0003002 337 0.011
negative regulation of defense response GO:0031348 77 0.011
neuron apoptotic process GO:0051402 142 0.011
regulation of cell cycle GO:0051726 281 0.011
regulation of cell size GO:0008361 72 0.011
regulation of protein transport GO:0051223 163 0.011
myeloid cell differentiation GO:0030099 233 0.011
acylglycerol metabolic process GO:0006639 55 0.011
regulation of t cell activation GO:0050863 170 0.011
neural tube closure GO:0001843 90 0.011
microtubule cytoskeleton organization GO:0000226 157 0.011
amino acid transport GO:0006865 61 0.011
sterol transport GO:0015918 38 0.011
p38mapk cascade GO:0038066 4 0.011
ensheathment of neurons GO:0007272 76 0.011
cellular response to extracellular stimulus GO:0031668 81 0.011
cellular response to acid chemical GO:0071229 68 0.011
regulation of lymphocyte proliferation GO:0050670 117 0.011
regulation of leukocyte differentiation GO:1902105 159 0.011
positive regulation of secretion by cell GO:1903532 114 0.011
regulation of reactive oxygen species biosynthetic process GO:1903426 2 0.011
homeostasis of number of cells GO:0048872 210 0.011
g protein coupled receptor signaling pathway GO:0007186 243 0.011
organic acid catabolic process GO:0016054 51 0.011
cell adhesion GO:0007155 329 0.011
divalent metal ion transport GO:0070838 172 0.011
spermatid development GO:0007286 108 0.011
cellular protein complex assembly GO:0043623 116 0.011
er associated ubiquitin dependent protein catabolic process GO:0030433 10 0.011
dna endoreduplication GO:0042023 4 0.011
protein modification by small protein conjugation GO:0032446 187 0.011
positive regulation of apoptotic signaling pathway GO:2001235 95 0.011
regulation of cytoplasmic translation GO:2000765 4 0.011
copii coated vesicle budding GO:0090114 2 0.011
lipid catabolic process GO:0016042 69 0.011
Human
epithelial tube morphogenesis GO:0060562 303 0.011
defense response to bacterium GO:0042742 119 0.011
positive regulation of cell migration GO:0030335 109 0.011
rab protein signal transduction GO:0032482 1 0.011
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 61 0.010
hormone secretion GO:0046879 128 0.010
negative regulation of growth GO:0045926 99 0.010
connective tissue development GO:0061448 179 0.010
regulation of steroid biosynthetic process GO:0050810 26 0.010
myelination GO:0042552 74 0.010
negative regulation of organelle organization GO:0010639 90 0.010
regulation of mrna polyadenylation GO:1900363 1 0.010
regulation of cell activation GO:0050865 289 0.010
regulation of cytoplasmic transport GO:1903649 112 0.010
exocytosis GO:0006887 121 0.010
regulation of homeostatic process GO:0032844 182 0.010
negative regulation of cell activation GO:0050866 111 0.010
meiosis i GO:0007127 60 0.010
positive regulation of neuron projection development GO:0010976 79 0.010
nuclear import GO:0051170 95 0.010
endomembrane system organization GO:0010256 147 0.010
lipid homeostasis GO:0055088 63 0.010
positive regulation of cell development GO:0010720 237 0.010
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 40 0.010
centrosome separation GO:0051299 4 0.010
cellular response to external stimulus GO:0071496 88 0.010
sensory organ morphogenesis GO:0090596 242 0.010
synaptic transmission GO:0007268 329 0.010

Pnpla8 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.020
nervous system disease DOID:863 0 0.020
disease of metabolism DOID:0014667 0 0.019
inherited metabolic disorder DOID:655 0 0.017
retinal disease DOID:5679 0 0.016
retinal degeneration DOID:8466 0 0.016
sensory system disease DOID:0050155 0 0.016
eye and adnexa disease DOID:1492 0 0.016
eye disease DOID:5614 0 0.016