Mus musculus

28 known processes

Pola1

polymerase (DNA directed), alpha 1

(Aliases: Pola,AW321876)

Pola1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
dna metabolic process GO:0006259 303 0.945
double strand break repair GO:0006302 48 0.840
Human Yeast
meiosis i GO:0007127 60 0.772
meiotic cell cycle process GO:1903046 77 0.725
Yeast
telomere capping GO:0016233 4 0.564
dna dependent dna replication GO:0006261 24 0.546
Human
chromosome organization involved in meiosis GO:0070192 39 0.425
meiotic cell cycle GO:0051321 122 0.416
Yeast
meiotic chromosome segregation GO:0045132 19 0.357
cellular nitrogen compound catabolic process GO:0044270 280 0.305
microtubule cytoskeleton organization GO:0000226 157 0.301
synapsis GO:0007129 34 0.283
meiotic nuclear division GO:0007126 115 0.274
dna replication GO:0006260 52 0.259
gonad development GO:0008406 141 0.253
dna conformation change GO:0071103 37 0.244
protein import into nucleus GO:0006606 95 0.226
dna biosynthetic process GO:0071897 22 0.225
purine nucleotide catabolic process GO:0006195 211 0.218
establishment of organelle localization GO:0051656 122 0.188
Worm
dna repair GO:0006281 107 0.188
Human Yeast
purine ribonucleotide metabolic process GO:0009150 290 0.177
negative regulation of cell cycle GO:0045786 123 0.175
regulation of cell cycle GO:0051726 281 0.171
double strand break repair via homologous recombination GO:0000724 21 0.164
endocytosis GO:0006897 168 0.155
receptor mediated endocytosis GO:0006898 51 0.154
establishment of protein localization to organelle GO:0072594 118 0.146
organelle assembly GO:0070925 177 0.145
protein targeting GO:0006605 143 0.145
recombinational repair GO:0000725 21 0.145
nucleocytoplasmic transport GO:0006913 139 0.140
development of primary sexual characteristics GO:0045137 143 0.135
nucleoside phosphate catabolic process GO:1901292 222 0.133
membrane organization GO:0061024 245 0.131
nuclear transport GO:0051169 139 0.129
intrinsic apoptotic signaling pathway GO:0097193 132 0.116
nucleobase containing small molecule metabolic process GO:0055086 352 0.114
glycosyl compound metabolic process GO:1901657 246 0.112
dna endoreduplication GO:0042023 4 0.109
organic cyclic compound catabolic process GO:1901361 295 0.108
regulation of dna dependent dna replication GO:0090329 8 0.107
regulation of apoptotic signaling pathway GO:2001233 197 0.106
apoptotic signaling pathway GO:0097190 306 0.105
nucleotide catabolic process GO:0009166 217 0.101
extrinsic apoptotic signaling pathway GO:0097191 126 0.101
ribonucleotide catabolic process GO:0009261 208 0.097
protein catabolic process GO:0030163 221 0.095
purine nucleoside triphosphate catabolic process GO:0009146 203 0.093
purine nucleoside metabolic process GO:0042278 241 0.093
cellular response to radiation GO:0071478 28 0.092
intracellular protein transport GO:0006886 204 0.091
protein import GO:0017038 101 0.090
cellular response to abiotic stimulus GO:0071214 56 0.088
maintenance of location GO:0051235 89 0.087
cellular macromolecule catabolic process GO:0044265 206 0.087
microtubule organizing center organization GO:0031023 28 0.086
regulation of cytoskeleton organization GO:0051493 122 0.084
intra s dna damage checkpoint GO:0031573 4 0.083
single organism nuclear import GO:1902593 95 0.083
mitotic chromosome condensation GO:0007076 1 0.082
nuclear import GO:0051170 95 0.082
microtubule based process GO:0007017 236 0.079
reciprocal dna recombination GO:0035825 16 0.078
female meiotic division GO:0007143 21 0.077
purine containing compound metabolic process GO:0072521 311 0.076
nucleotide metabolic process GO:0009117 332 0.074
macromolecule catabolic process GO:0009057 281 0.073
purine nucleoside catabolic process GO:0006152 205 0.073
protein localization to nucleus GO:0034504 121 0.072
dna packaging GO:0006323 30 0.072
purine nucleoside triphosphate metabolic process GO:0009144 226 0.070
genitalia development GO:0048806 37 0.069
amine metabolic process GO:0009308 45 0.068
engulfment of apoptotic cell GO:0043652 3 0.068
cellular protein complex assembly GO:0043623 116 0.068
regulation of cellular amino acid metabolic process GO:0006521 5 0.066
heterocycle catabolic process GO:0046700 280 0.065
cellular ketone metabolic process GO:0042180 84 0.065
telomere maintenance GO:0000723 19 0.065
cellular response to dna damage stimulus GO:0006974 207 0.064
Human Yeast
regulation of meiosis i GO:0060631 7 0.064
nucleoside phosphate metabolic process GO:0006753 338 0.063
positive regulation of hydrolase activity GO:0051345 148 0.063
cellular amino acid metabolic process GO:0006520 103 0.062
regulation of organelle organization GO:0033043 289 0.060
ribonucleotide metabolic process GO:0009259 291 0.059
cellular response to organonitrogen compound GO:0071417 145 0.058
ribose phosphate metabolic process GO:0019693 291 0.056
ribonucleoside metabolic process GO:0009119 245 0.056
anatomical structure homeostasis GO:0060249 145 0.055
regulation of kinase activity GO:0043549 249 0.054
male meiosis GO:0007140 37 0.054
nucleoside metabolic process GO:0009116 246 0.054
regulation of transferase activity GO:0051338 263 0.053
glycosyl compound catabolic process GO:1901658 206 0.053
cell division GO:0051301 120 0.052
organonitrogen compound catabolic process GO:1901565 264 0.052
nucleic acid phosphodiester bond hydrolysis GO:0090305 49 0.052
male gamete generation GO:0048232 285 0.051
regulation of hydrolase activity GO:0051336 246 0.051
spermatogenesis GO:0007283 284 0.050
female meiosis chromosome segregation GO:0016321 1 0.050
organelle fission GO:0048285 170 0.050
cellular response to ionizing radiation GO:0071479 11 0.049
regulation of cellular ketone metabolic process GO:0010565 66 0.049
protein localization to organelle GO:0033365 185 0.049
mitotic g2 dna damage checkpoint GO:0007095 8 0.049
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.048
regulation of cell cycle process GO:0010564 160 0.048
cytoplasmic transport GO:0016482 234 0.046
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.046
negative regulation of cellular component organization GO:0051129 194 0.046
aromatic compound catabolic process GO:0019439 286 0.046
nucleoside catabolic process GO:0009164 206 0.046
ribonucleoside triphosphate metabolic process GO:0009199 220 0.045
regulation of mitosis GO:0007088 29 0.045
regulation of cell division GO:0051302 76 0.044
cellular amine metabolic process GO:0044106 44 0.044
response to organonitrogen compound GO:0010243 246 0.044
negative regulation of mitotic cell cycle phase transition GO:1901991 45 0.043
purine nucleotide metabolic process GO:0006163 302 0.043
regulation of cellular component biogenesis GO:0044087 181 0.042
carbohydrate derivative catabolic process GO:1901136 231 0.041
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.041
mitotic cell cycle process GO:1903047 159 0.041
regulation of mitotic cell cycle phase transition GO:1901990 73 0.041
response to radiation GO:0009314 165 0.041
negative regulation of cell cycle process GO:0010948 69 0.041
cell type specific apoptotic process GO:0097285 268 0.041
spindle assembly involved in female meiosis GO:0007056 3 0.040
rho protein signal transduction GO:0007266 32 0.040
cellular protein catabolic process GO:0044257 155 0.040
centrosome organization GO:0051297 26 0.039
cell fate commitment GO:0045165 210 0.039
regulation of cellular amine metabolic process GO:0033238 20 0.039
mitotic cytokinesis GO:0000281 4 0.039
spindle assembly involved in meiosis GO:0090306 4 0.038
positive regulation of protein kinase activity GO:0045860 144 0.038
regulation of centriole replication GO:0046599 1 0.037
mitotic cell cycle GO:0000278 195 0.036
purine ribonucleotide catabolic process GO:0009154 208 0.036
response to organic cyclic compound GO:0014070 198 0.035
regulation of purine nucleotide metabolic process GO:1900542 169 0.035
mitochondrion organization GO:0007005 134 0.034
positive regulation of cellular amine metabolic process GO:0033240 5 0.034
translesion synthesis GO:0019985 1 0.034
purine ribonucleoside metabolic process GO:0046128 241 0.034
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.033
nucleoside triphosphate catabolic process GO:0009143 205 0.032
regulation of dna replication GO:0006275 17 0.032
small gtpase mediated signal transduction GO:0007264 97 0.032
regulation of nucleoside metabolic process GO:0009118 130 0.032
spindle assembly involved in mitosis GO:0090307 4 0.032
muscle cell differentiation GO:0042692 261 0.032
regulation of protein kinase activity GO:0045859 232 0.032
negative regulation of meiotic cell cycle GO:0051447 14 0.031
positive regulation of protein modification process GO:0031401 299 0.031
organophosphate catabolic process GO:0046434 232 0.031
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.031
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.030
regulation of chromosome organization GO:0033044 83 0.030
nuclear dna replication GO:0033260 3 0.030
germ cell development GO:0007281 185 0.029
nucleoside monophosphate metabolic process GO:0009123 85 0.029
regulation of cellular catabolic process GO:0031329 242 0.029
regulation of mitotic cell cycle GO:0007346 126 0.029
purine containing compound catabolic process GO:0072523 213 0.029
mitotic recombination GO:0006312 3 0.028
heterochromatin assembly GO:0031507 2 0.028
striated muscle myosin thick filament assembly GO:0071688 1 0.028
positive regulation of cell development GO:0010720 237 0.027
dna catabolic process GO:0006308 19 0.027
multicellular organism growth GO:0035264 161 0.027
protein oligomerization GO:0051259 67 0.027
blood vessel morphogenesis GO:0048514 285 0.027
chromosome segregation GO:0007059 48 0.026
negative regulation of dna dependent dna replication GO:2000104 1 0.026
cellular response to oxidative stress GO:0034599 76 0.026
negative regulation of cell cycle phase transition GO:1901988 48 0.026
negative regulation of organelle organization GO:0010639 90 0.026
ribonucleoside catabolic process GO:0042454 206 0.026
regulation of chromatin modification GO:1903308 57 0.026
digestive tract morphogenesis GO:0048546 147 0.025
regulation of protein localization GO:0032880 231 0.025
regulation of dna recombination GO:0000018 34 0.025
microtubule cytoskeleton organization involved in mitosis GO:1902850 4 0.025
purine nucleoside monophosphate metabolic process GO:0009126 81 0.024
protein autophosphorylation GO:0046777 61 0.024
wnt signaling pathway GO:0016055 188 0.024
innate immune response GO:0045087 157 0.024
myosin filament organization GO:0031033 3 0.024
positive regulation of nervous system development GO:0051962 221 0.024
cell cycle checkpoint GO:0000075 47 0.024
heterochromatin organization GO:0070828 4 0.024
cellular component assembly involved in morphogenesis GO:0010927 139 0.023
regulation of nucleotide metabolic process GO:0006140 169 0.023
negative regulation of nuclear division GO:0051784 19 0.023
chromatin assembly or disassembly GO:0006333 16 0.023
t cell apoptotic process GO:0070231 39 0.023
response to light stimulus GO:0009416 135 0.023
mrna 3 end processing GO:0031124 16 0.023
response to oxidative stress GO:0006979 123 0.023
multi multicellular organism process GO:0044706 109 0.022
response to denervation involved in regulation of muscle adaptation GO:0014894 4 0.022
dna catabolic process endonucleolytic GO:0000737 15 0.022
reciprocal meiotic recombination GO:0007131 16 0.022
dna recombination GO:0006310 92 0.021
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.021
cellular response to organic cyclic compound GO:0071407 87 0.021
positive regulation of peptidase activity GO:0010952 49 0.021
dna dependent dna replication maintenance of fidelity GO:0045005 3 0.021
cellular response to hormone stimulus GO:0032870 150 0.021
actomyosin structure organization GO:0031032 56 0.021
lateral inhibition GO:0046331 1 0.021
striated muscle cell development GO:0055002 125 0.021
methylation GO:0032259 134 0.021
protein maturation GO:0051604 176 0.021
neuron death GO:0070997 154 0.021
peptidyl amino acid modification GO:0018193 336 0.020
regulation of endopeptidase activity GO:0052548 89 0.020
response to uv GO:0009411 44 0.020
regulation of nuclear cell cycle dna replication GO:0033262 2 0.020
nucleoside triphosphate metabolic process GO:0009141 230 0.020
placenta development GO:0001890 140 0.020
establishment or maintenance of cell polarity GO:0007163 86 0.020
neuron apoptotic process GO:0051402 142 0.020
negative regulation of molecular function GO:0044092 258 0.020
regulation of protein depolymerization GO:1901879 26 0.019
regulation of transcription by chromatin organization GO:0034401 0 0.019
regulation of cellular response to stress GO:0080135 159 0.019
sister chromatid segregation GO:0000819 20 0.019
chromatin organization GO:0006325 206 0.019
regulation of histone modification GO:0031056 56 0.019
response to inorganic substance GO:0010035 96 0.019
cellular protein complex disassembly GO:0043624 36 0.019
positive regulation of purine nucleotide catabolic process GO:0033123 88 0.018
leukocyte proliferation GO:0070661 172 0.018
double strand break repair via nonhomologous end joining GO:0006303 10 0.018
Human
positive regulation of nucleotide catabolic process GO:0030813 88 0.018
membrane invagination GO:0010324 17 0.018
compound eye development GO:0048749 1 0.018
dna methylation GO:0006306 43 0.018
muscle tissue development GO:0060537 308 0.018
carbohydrate derivative biosynthetic process GO:1901137 183 0.018
regulation of actin filament based process GO:0032970 99 0.018
negative regulation of phosphate metabolic process GO:0045936 184 0.018
dna modification GO:0006304 50 0.018
protein secretion GO:0009306 111 0.018
regulation of neuron death GO:1901214 134 0.018
posttranscriptional regulation of gene expression GO:0010608 155 0.017
positive regulation of neuron differentiation GO:0045666 141 0.017
atp catabolic process GO:0006200 55 0.017
negative regulation of cellular amine metabolic process GO:0033239 1 0.017
cdc42 protein signal transduction GO:0032488 0 0.017
sensory perception GO:0007600 245 0.017
ras protein signal transduction GO:0007265 77 0.017
cell aging GO:0007569 35 0.017
positive regulation of nucleoside metabolic process GO:0045979 91 0.017
cellular lipid metabolic process GO:0044255 323 0.017
negative regulation of dna replication GO:0008156 4 0.017
regulation of dna endoreduplication GO:0032875 3 0.017
positive regulation of programmed cell death GO:0043068 218 0.016
female gamete generation GO:0007292 74 0.016
purine ribonucleoside catabolic process GO:0046130 205 0.016
regulation of protein serine threonine kinase activity GO:0071900 157 0.016
nuclear division GO:0000280 158 0.016
regulation of membrane potential GO:0042391 192 0.016
digestive system development GO:0055123 200 0.016
dna duplex unwinding GO:0032508 7 0.016
positive regulation of cell death GO:0010942 224 0.016
locomotory behavior GO:0007626 195 0.016
regulation of cysteine type endopeptidase activity GO:2000116 65 0.016
regulation of rho gtpase activity GO:0032319 58 0.016
response to purine containing compound GO:0014074 28 0.016
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 57 0.015
regulation of chromatin silencing GO:0031935 2 0.015
interleukin 1 alpha secretion GO:0050703 3 0.015
negative regulation of microtubule polymerization or depolymerization GO:0031111 15 0.015
myosin filament assembly GO:0031034 2 0.015
muscle cell development GO:0055001 133 0.015
angiogenesis GO:0001525 201 0.015
regulation of purine nucleotide catabolic process GO:0033121 122 0.015
apoptotic mitochondrial changes GO:0008637 48 0.015
response to growth factor GO:0070848 198 0.015
regulation of cell cycle phase transition GO:1901987 77 0.015
regulation of wnt signaling pathway GO:0030111 123 0.015
regulation of peptidase activity GO:0052547 96 0.015
organophosphate biosynthetic process GO:0090407 122 0.015
cytokinetic process GO:0032506 2 0.015
actin cytoskeleton organization GO:0030036 220 0.015
regulation of cell projection organization GO:0031344 206 0.015
developmental maturation GO:0021700 193 0.014
cellular response to growth factor stimulus GO:0071363 197 0.014
positive regulation of transferase activity GO:0051347 167 0.014
positive regulation of cellular component biogenesis GO:0044089 94 0.014
nucleus organization GO:0006997 45 0.014
peptidyl serine phosphorylation GO:0018105 74 0.014
axonogenesis GO:0007409 274 0.014
endomembrane system organization GO:0010256 147 0.014
positive regulation of gtp catabolic process GO:0033126 85 0.014
protein import into nucleus translocation GO:0000060 12 0.014
kinetochore organization GO:0051383 2 0.014
lymphocyte proliferation GO:0046651 164 0.014
positive regulation of organelle organization GO:0010638 128 0.014
dna alkylation GO:0006305 43 0.014
response to topologically incorrect protein GO:0035966 25 0.014
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.013
nitrogen compound transport GO:0071705 271 0.013
negative regulation of phosphorylation GO:0042326 166 0.013
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 62 0.013
positive regulation of apoptotic process GO:0043065 217 0.013
negative regulation of apoptotic signaling pathway GO:2001234 104 0.013
developmental cell growth GO:0048588 84 0.013
regulation of cell motility GO:2000145 236 0.013
skeletal muscle organ development GO:0060538 163 0.013
organelle localization GO:0051640 179 0.013
Worm
response to ionizing radiation GO:0010212 42 0.013
dendrite development GO:0016358 115 0.013
regulation of neuron apoptotic process GO:0043523 122 0.013
dna damage checkpoint GO:0000077 26 0.013
neural precursor cell proliferation GO:0061351 121 0.013
morphogenesis of a branching epithelium GO:0061138 193 0.013
positive regulation of cysteine type endopeptidase activity GO:2001056 39 0.013
positive regulation of protein transport GO:0051222 93 0.013
inflammatory response GO:0006954 244 0.013
regulation of protein localization to nucleus GO:1900180 60 0.013
regulation of protein transport GO:0051223 163 0.013
proteasomal protein catabolic process GO:0010498 98 0.013
response to lipopolysaccharide GO:0032496 128 0.013
atp metabolic process GO:0046034 75 0.012
neuron migration GO:0001764 122 0.012
positive regulation of secretion GO:0051047 130 0.012
mapk cascade GO:0000165 281 0.012
regulation of leukocyte apoptotic process GO:2000106 56 0.012
negative regulation of kinase activity GO:0033673 81 0.012
viral entry into host cell GO:0046718 15 0.012
male meiosis i GO:0007141 16 0.012
i kappab kinase nf kappab signaling GO:0007249 85 0.012
purine nucleoside monophosphate catabolic process GO:0009128 58 0.012
negative regulation of cell division GO:0051782 24 0.012
er nucleus signaling pathway GO:0006984 27 0.012
regulation of proteolysis GO:0030162 164 0.012
rna catabolic process GO:0006401 29 0.012
cytokine production GO:0001816 319 0.012
phagocytosis GO:0006909 66 0.012
apoptotic nuclear changes GO:0030262 9 0.012
cellular response to lipid GO:0071396 145 0.012
positive regulation of rac gtpase activity GO:0032855 14 0.012
gene silencing GO:0016458 38 0.012
epithelial tube morphogenesis GO:0060562 303 0.012
developmental growth involved in morphogenesis GO:0060560 138 0.012
centromere complex assembly GO:0034508 3 0.012
regulation of cell activation GO:0050865 289 0.012
dna replication initiation GO:0006270 5 0.012
Human
spermatid development GO:0007286 108 0.012
regulation of neuron differentiation GO:0045664 281 0.012
negative regulation of cellular protein metabolic process GO:0032269 247 0.012
zymogen activation GO:0031638 41 0.012
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.012
cell maturation GO:0048469 127 0.012
mitotic cell cycle checkpoint GO:0007093 31 0.012
embryonic placenta development GO:0001892 98 0.012
regulation of ras gtpase activity GO:0032318 88 0.012
dna hypermethylation GO:0044026 3 0.011
positive regulation of gtpase activity GO:0043547 85 0.011
canonical wnt signaling pathway GO:0060070 130 0.011
urogenital system development GO:0001655 261 0.011
establishment or maintenance of microtubule cytoskeleton polarity GO:0030951 1 0.011
leukocyte differentiation GO:0002521 342 0.011
ribonucleoside monophosphate catabolic process GO:0009158 57 0.011
histone modification GO:0016570 159 0.011
regulation of binding GO:0051098 111 0.011
cellular response to peptide GO:1901653 92 0.011
srebp signaling pathway GO:0032933 4 0.011
cellular component disassembly involved in execution phase of apoptosis GO:0006921 9 0.011
response to steroid hormone GO:0048545 56 0.011
apoptotic dna fragmentation GO:0006309 7 0.011
positive regulation of cell cycle process GO:0090068 61 0.011
cellular response to acid chemical GO:0071229 68 0.011
adult behavior GO:0030534 135 0.011
rna 3 end processing GO:0031123 20 0.011
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 55 0.011
regulation of interleukin 1 alpha production GO:0032650 4 0.011
response to hypoxia GO:0001666 58 0.011
anion transport GO:0006820 177 0.011
neural tube formation GO:0001841 108 0.011
apoptotic cell clearance GO:0043277 17 0.011
negative regulation of meiotic cell cycle phase transition GO:1901994 3 0.011
multi organism behavior GO:0051705 62 0.011
positive regulation of mapk cascade GO:0043410 170 0.011
nucleoside monophosphate catabolic process GO:0009125 59 0.011
regulation of lymphocyte apoptotic process GO:0070228 41 0.011
b cell activation GO:0042113 161 0.011
metaphase plate congression GO:0051310 2 0.011
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.010
regulation of rho protein signal transduction GO:0035023 71 0.010
response to endoplasmic reticulum stress GO:0034976 53 0.010
skin development GO:0043588 220 0.010
guanosine containing compound metabolic process GO:1901068 144 0.010
meiotic chromosome condensation GO:0010032 3 0.010
negative regulation of transferase activity GO:0051348 85 0.010
cellular response to inorganic substance GO:0071241 37 0.010
regulation of ras protein signal transduction GO:0046578 114 0.010
response to molecule of bacterial origin GO:0002237 143 0.010
mitotic centrosome separation GO:0007100 4 0.010
regulation of cell migration GO:0030334 219 0.010
cellular chemical homeostasis GO:0055082 215 0.010
mrna processing GO:0006397 63 0.010
sensory perception of sound GO:0007605 97 0.010
gtp catabolic process GO:0006184 143 0.010
macromolecular complex disassembly GO:0032984 43 0.010

Pola1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.014
disease of cellular proliferation DOID:14566 0 0.014
central nervous system disease DOID:331 0 0.014
disease of anatomical entity DOID:7 0 0.014
nervous system disease DOID:863 0 0.014
organ system cancer DOID:0050686 0 0.011