Mus musculus

6 known processes

Pot1a

protection of telomeres 1A

(Aliases: AI851169,1500031H18Rik,Pot1)

Pot1a biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
protection from non homologous end joining at telomere GO:0031848 4 0.988
Mouse
ubiquitin dependent protein catabolic process GO:0006511 129 0.104
anatomical structure homeostasis GO:0060249 145 0.096
Mouse
cellular macromolecule catabolic process GO:0044265 206 0.096
methylation GO:0032259 134 0.095
chromatin organization GO:0006325 206 0.093
modification dependent macromolecule catabolic process GO:0043632 133 0.092
telomere maintenance GO:0000723 19 0.071
Mouse
chromatin modification GO:0016568 187 0.068
organonitrogen compound catabolic process GO:1901565 264 0.067
dna metabolic process GO:0006259 303 0.064
Mouse
microtubule polymerization or depolymerization GO:0031109 26 0.064
regulation of microtubule polymerization or depolymerization GO:0031110 20 0.063
histone modification GO:0016570 159 0.063
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 40 0.062
telomere maintenance in response to dna damage GO:0043247 4 0.062
Mouse
mitotic cell cycle GO:0000278 195 0.061
microtubule cytoskeleton organization GO:0000226 157 0.060
macromolecule catabolic process GO:0009057 281 0.059
negative regulation of cellular protein metabolic process GO:0032269 247 0.059
protein polymerization GO:0051258 57 0.054
regulation of organelle organization GO:0033043 289 0.054
mitotic spindle checkpoint GO:0071174 9 0.052
regulation of chromosome organization GO:0033044 83 0.052
regulation of microtubule based process GO:0032886 52 0.051
locomotory behavior GO:0007626 195 0.050
protein oligomerization GO:0051259 67 0.050
regulation of microtubule polymerization GO:0031113 7 0.048
regulation of transferase activity GO:0051338 263 0.045
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 56 0.045
cellular response to dna damage stimulus GO:0006974 207 0.045
Mouse
protein maturation GO:0051604 176 0.044
microtubule based process GO:0007017 236 0.043
negative regulation of cellular component organization GO:0051129 194 0.043
nucleobase containing small molecule metabolic process GO:0055086 352 0.043
regulation of cellular catabolic process GO:0031329 242 0.042
negative regulation of dna replication GO:0008156 4 0.041
regulation of mitotic cell cycle GO:0007346 126 0.041
regulation of cellular component biogenesis GO:0044087 181 0.041
telomere capping GO:0016233 4 0.041
Mouse
apoptotic signaling pathway GO:0097190 306 0.040
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.040
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.040
proteasomal protein catabolic process GO:0010498 98 0.040
nuclear division GO:0000280 158 0.039
protein catabolic process GO:0030163 221 0.039
aromatic compound catabolic process GO:0019439 286 0.039
regionalization GO:0003002 337 0.039
telomere maintenance via telomerase GO:0007004 1 0.039
ribose phosphate metabolic process GO:0019693 291 0.039
nucleoside metabolic process GO:0009116 246 0.039
purine nucleotide metabolic process GO:0006163 302 0.038
cellular protein catabolic process GO:0044257 155 0.038
dna biosynthetic process GO:0071897 22 0.038
glycosyl compound metabolic process GO:1901657 246 0.037
multicellular organismal homeostasis GO:0048871 164 0.037
ribonucleoside triphosphate metabolic process GO:0009199 220 0.037
rna dependent dna replication GO:0006278 3 0.037
regulation of cell cycle GO:0051726 281 0.036
negative regulation of molecular function GO:0044092 258 0.036
dna replication GO:0006260 52 0.036
leukocyte differentiation GO:0002521 342 0.036
mitotic cell cycle process GO:1903047 159 0.036
negative regulation of protein metabolic process GO:0051248 282 0.035
negative regulation of organelle organization GO:0010639 90 0.035
organelle fission GO:0048285 170 0.034
tissue homeostasis GO:0001894 115 0.033
vacuole organization GO:0007033 38 0.033
peptide metabolic process GO:0006518 46 0.033
cellular protein complex assembly GO:0043623 116 0.033
regulation of cellular amino acid metabolic process GO:0006521 5 0.033
regulation of proteolysis GO:0030162 164 0.032
negative regulation of cellular catabolic process GO:0031330 47 0.032
organic cyclic compound catabolic process GO:1901361 295 0.032
protein processing GO:0016485 163 0.032
regulation of protein catabolic process GO:0042176 108 0.032
nucleoside phosphate metabolic process GO:0006753 338 0.031
microtubule polymerization GO:0046785 12 0.031
cellular amine metabolic process GO:0044106 44 0.031
ribonucleotide catabolic process GO:0009261 208 0.031
regulation of cell cycle process GO:0010564 160 0.030
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.029
negative regulation of transferase activity GO:0051348 85 0.029
purine ribonucleotide catabolic process GO:0009154 208 0.029
ras protein signal transduction GO:0007265 77 0.028
positive regulation of organelle organization GO:0010638 128 0.028
regulation of nuclear division GO:0051783 56 0.028
positive regulation of cell death GO:0010942 224 0.028
peptidyl amino acid modification GO:0018193 336 0.028
carbohydrate derivative catabolic process GO:1901136 231 0.028
regulation of proteasomal protein catabolic process GO:0061136 46 0.028
purine nucleoside metabolic process GO:0042278 241 0.028
negative regulation of chromosome organization GO:2001251 30 0.027
nucleoside catabolic process GO:0009164 206 0.027
embryonic organ morphogenesis GO:0048562 276 0.027
regulation of cytoskeleton organization GO:0051493 122 0.027
purine containing compound catabolic process GO:0072523 213 0.027
regulation of homeostatic process GO:0032844 182 0.027
cellular ketone metabolic process GO:0042180 84 0.027
ribonucleotide metabolic process GO:0009259 291 0.027
covalent chromatin modification GO:0016569 163 0.027
nucleoside triphosphate metabolic process GO:0009141 230 0.026
ribonucleoside metabolic process GO:0009119 245 0.026
organophosphate catabolic process GO:0046434 232 0.026
regulation of cellular protein catabolic process GO:1903362 61 0.026
positive regulation of chromosome organization GO:2001252 33 0.026
regulation of protein maturation GO:1903317 96 0.026
heterocycle catabolic process GO:0046700 280 0.026
protein homooligomerization GO:0051260 43 0.026
cellular amino acid metabolic process GO:0006520 103 0.026
cell division GO:0051301 120 0.026
amine metabolic process GO:0009308 45 0.025
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.025
histone methylation GO:0016571 71 0.025
positive regulation of cellular component biogenesis GO:0044089 94 0.025
immune effector process GO:0002252 321 0.025
nucleotide catabolic process GO:0009166 217 0.025
t cell activation GO:0042110 289 0.025
positive regulation of cellular amine metabolic process GO:0033240 5 0.025
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.025
macromolecule methylation GO:0043414 120 0.025
negative regulation of nuclear division GO:0051784 19 0.025
lymphocyte differentiation GO:0030098 242 0.024
negative regulation of protein processing GO:0010955 79 0.024
purine ribonucleoside catabolic process GO:0046130 205 0.024
purine nucleoside triphosphate catabolic process GO:0009146 203 0.024
nucleotide metabolic process GO:0009117 332 0.024
positive regulation of programmed cell death GO:0043068 218 0.024
negative regulation of proteolysis GO:0045861 74 0.023
positive regulation of microtubule polymerization or depolymerization GO:0031112 3 0.023
regulation of protein processing GO:0070613 96 0.023
regulation of apoptotic signaling pathway GO:2001233 197 0.023
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.023
protein methylation GO:0006479 81 0.023
regulation of cell division GO:0051302 76 0.023
purine containing compound metabolic process GO:0072521 311 0.023
regulation of mitotic cell cycle phase transition GO:1901990 73 0.022
purine ribonucleoside metabolic process GO:0046128 241 0.022
negative regulation of protein maturation GO:1903318 79 0.022
skeletal system development GO:0001501 356 0.022
positive regulation of protein complex assembly GO:0031334 45 0.022
regulation of cellular amine metabolic process GO:0033238 20 0.022
negative regulation of homeostatic process GO:0032845 71 0.022
protein alkylation GO:0008213 81 0.022
negative regulation of cell cycle process GO:0010948 69 0.022
chromosome separation GO:0051304 14 0.022
histone lysine methylation GO:0034968 50 0.022
ribonucleoside triphosphate catabolic process GO:0009203 199 0.021
mitotic nuclear division GO:0007067 48 0.021
purine nucleoside catabolic process GO:0006152 205 0.021
b cell activation GO:0042113 161 0.021
sensory organ morphogenesis GO:0090596 242 0.021
negative regulation of proteolysis involved in cellular protein catabolic process GO:1903051 22 0.021
negative regulation of cell cycle GO:0045786 123 0.021
positive regulation of homeostatic process GO:0032846 64 0.021
positive regulation of protein modification process GO:0031401 299 0.021
regulation of cell cycle phase transition GO:1901987 77 0.020
mitotic cell cycle checkpoint GO:0007093 31 0.020
gland development GO:0048732 330 0.020
negative regulation of mitotic cell cycle GO:0045930 58 0.020
protein modification by small protein conjugation or removal GO:0070647 207 0.020
cellular nitrogen compound catabolic process GO:0044270 280 0.020
negative regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032435 15 0.020
sensory perception GO:0007600 245 0.020
epithelial tube morphogenesis GO:0060562 303 0.020
protein ubiquitination GO:0016567 171 0.020
ribonucleoside catabolic process GO:0042454 206 0.020
mitotic sister chromatid separation GO:0051306 9 0.020
purine ribonucleotide metabolic process GO:0009150 290 0.020
negative regulation of cellular protein catabolic process GO:1903363 22 0.020
positive regulation of apoptotic process GO:0043065 217 0.019
nucleoside triphosphate catabolic process GO:0009143 205 0.019
cation transport GO:0006812 399 0.019
positive regulation of microtubule polymerization GO:0031116 3 0.019
regulation of cell activation GO:0050865 289 0.019
small gtpase mediated signal transduction GO:0007264 97 0.019
stem cell development GO:0048864 219 0.019
protein modification by small protein conjugation GO:0032446 187 0.018
nucleoside phosphate catabolic process GO:1901292 222 0.018
cell cycle checkpoint GO:0000075 47 0.018
positive regulation of cell development GO:0010720 237 0.018
transmembrane transport GO:0055085 412 0.018
regulation of cytokine production GO:0001817 266 0.018
camera type eye development GO:0043010 266 0.018
lysosome organization GO:0007040 21 0.018
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.017
regulation of cellular ketone metabolic process GO:0010565 66 0.017
mapk cascade GO:0000165 281 0.017
sister chromatid segregation GO:0000819 20 0.017
chromosome segregation GO:0007059 48 0.017
positive regulation of cytoskeleton organization GO:0051495 49 0.017
positive regulation of nervous system development GO:0051962 221 0.017
neuromuscular process GO:0050905 99 0.017
purine nucleoside triphosphate metabolic process GO:0009144 226 0.017
regulation of t cell activation GO:0050863 170 0.016
glycosyl compound catabolic process GO:1901658 206 0.016
purine nucleotide catabolic process GO:0006195 211 0.016
peptidyl lysine modification GO:0018205 77 0.016
cellular response to lipid GO:0071396 145 0.016
cytoplasmic transport GO:0016482 234 0.016
g protein coupled receptor signaling pathway GO:0007186 243 0.016
regulation of neuron differentiation GO:0045664 281 0.016
neuromuscular process controlling balance GO:0050885 59 0.016
regulation of cell migration GO:0030334 219 0.016
spermatogenesis GO:0007283 284 0.016
regulation of cell motility GO:2000145 236 0.016
response to organonitrogen compound GO:0010243 246 0.016
positive regulation of cell cycle process GO:0090068 61 0.016
appendage morphogenesis GO:0035107 149 0.016
urogenital system development GO:0001655 261 0.016
compound eye development GO:0048749 1 0.015
cellular amide metabolic process GO:0043603 58 0.015
positive regulation of nuclear division GO:0051785 27 0.015
respiratory system development GO:0060541 190 0.015
appendage development GO:0048736 166 0.015
negative regulation of cell cycle phase transition GO:1901988 48 0.015
cation transmembrane transport GO:0098655 266 0.015
metaphase anaphase transition of mitotic cell cycle GO:0007091 9 0.015
cytokine production GO:0001816 319 0.015
heart morphogenesis GO:0003007 178 0.015
mitotic sister chromatid segregation GO:0000070 14 0.015
regulation of dna methylation GO:0044030 12 0.015
negative regulation of cell proliferation GO:0008285 296 0.015
negative regulation of protein catabolic process GO:0042177 36 0.015
nucleoside monophosphate metabolic process GO:0009123 85 0.015
blood circulation GO:0008015 195 0.014
regulation of mitosis GO:0007088 29 0.014
intracellular protein transport GO:0006886 204 0.014
morphogenesis of embryonic epithelium GO:0016331 159 0.014
positive regulation of cell cycle GO:0045787 92 0.014
regulation of telomerase activity GO:0051972 1 0.014
atp metabolic process GO:0046034 75 0.014
regulation of lymphocyte activation GO:0051249 240 0.014
cell type specific apoptotic process GO:0097285 268 0.014
ear development GO:0043583 200 0.014
axonogenesis GO:0007409 274 0.014
forebrain development GO:0030900 302 0.014
leukocyte activation involved in immune response GO:0002366 126 0.014
coenzyme a metabolic process GO:0015936 8 0.014
negative regulation of cell division GO:0051782 24 0.013
regulation of chromosome segregation GO:0051983 21 0.013
dna alkylation GO:0006305 43 0.013
protein acylation GO:0043543 64 0.013
leukocyte mediated immunity GO:0002443 174 0.013
ossification GO:0001503 216 0.013
positive regulation of cell activation GO:0050867 158 0.013
renal system development GO:0072001 225 0.013
purine nucleoside monophosphate catabolic process GO:0009128 58 0.013
regulation of histone modification GO:0031056 56 0.013
intrinsic apoptotic signaling pathway GO:0097193 132 0.013
inflammatory response GO:0006954 244 0.013
neuron death GO:0070997 154 0.013
organonitrogen compound biosynthetic process GO:1901566 192 0.013
dna modification GO:0006304 50 0.013
membrane organization GO:0061024 245 0.013
lymphocyte activation involved in immune response GO:0002285 93 0.013
dna catabolic process endonucleolytic GO:0000737 15 0.013
maintenance of location GO:0051235 89 0.013
regulation of sister chromatid segregation GO:0033045 13 0.013
cellular response to growth factor stimulus GO:0071363 197 0.013
response to growth factor GO:0070848 198 0.013
response to radiation GO:0009314 165 0.013
dna methylation GO:0006306 43 0.013
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.012
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.012
bone remodeling GO:0046849 53 0.012
positive regulation of cell division GO:0051781 31 0.012
mitochondrion organization GO:0007005 134 0.012
negative regulation of cellular amine metabolic process GO:0033239 1 0.012
regulation of chromatin modification GO:1903308 57 0.012
organelle assembly GO:0070925 177 0.012
regulation of secretion GO:0051046 274 0.012
reactive oxygen species metabolic process GO:0072593 84 0.012
t cell differentiation GO:0030217 174 0.012
meiotic nuclear division GO:0007126 115 0.012
nitrogen compound transport GO:0071705 271 0.012
organelle localization GO:0051640 179 0.012
embryonic appendage morphogenesis GO:0035113 126 0.012
circulatory system process GO:0003013 197 0.012
smoothened signaling pathway GO:0007224 105 0.012
leukocyte proliferation GO:0070661 172 0.012
posttranscriptional regulation of gene expression GO:0010608 155 0.012
negative regulation of protein modification process GO:0031400 163 0.012
protein localization to organelle GO:0033365 185 0.012
trna wobble base modification GO:0002097 2 0.012
atp catabolic process GO:0006200 55 0.012
negative regulation of cell development GO:0010721 169 0.012
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.012
intestinal epithelial structure maintenance GO:0060729 4 0.012
negative regulation of mitotic cell cycle phase transition GO:1901991 45 0.012
divalent inorganic cation transport GO:0072511 178 0.012
negative regulation of intracellular signal transduction GO:1902532 167 0.012
regulation of histone methylation GO:0031060 30 0.012
rho protein signal transduction GO:0007266 32 0.012
cellular homeostasis GO:0019725 240 0.012
lung development GO:0030324 164 0.012
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.012
negative regulation of growth GO:0045926 99 0.012
regulation of secretion by cell GO:1903530 249 0.012
blood vessel morphogenesis GO:0048514 285 0.012
regulation of membrane potential GO:0042391 192 0.012
positive regulation of transferase activity GO:0051347 167 0.011
regulation of cellular response to growth factor stimulus GO:0090287 82 0.011
regulation of system process GO:0044057 200 0.011
response to light stimulus GO:0009416 135 0.011
respiratory tube development GO:0030323 167 0.011
oxidation reduction process GO:0055114 342 0.011
regulation of mapk cascade GO:0043408 248 0.011
epithelial cell proliferation GO:0050673 174 0.011
ion transmembrane transport GO:0034220 361 0.011
neural tube development GO:0021915 160 0.011
neural precursor cell proliferation GO:0061351 121 0.011
lateral inhibition GO:0046331 1 0.011
morphogenesis of a branching epithelium GO:0061138 193 0.011
positive regulation of hydrolase activity GO:0051345 148 0.011
cellular response to molecule of bacterial origin GO:0071219 83 0.011
purine nucleoside monophosphate metabolic process GO:0009126 81 0.011
developmental growth involved in morphogenesis GO:0060560 138 0.011
male gamete generation GO:0048232 285 0.011
wound healing GO:0042060 157 0.011
bone resorption GO:0045453 38 0.011
skeletal muscle organ development GO:0060538 163 0.011
carbohydrate derivative biosynthetic process GO:1901137 183 0.011
negative regulation of neuron death GO:1901215 98 0.011
positive regulation of mitotic cell cycle GO:0045931 41 0.011
embryonic limb morphogenesis GO:0030326 126 0.011
cellular response to hormone stimulus GO:0032870 150 0.011
nucleoside monophosphate catabolic process GO:0009125 59 0.011
developmental maturation GO:0021700 193 0.011
blastocyst development GO:0001824 80 0.011
regulation of hydrolase activity GO:0051336 246 0.011
chemotaxis GO:0006935 247 0.011
positive regulation of mapk cascade GO:0043410 170 0.011
limb morphogenesis GO:0035108 149 0.011
cellular response to gamma radiation GO:0071480 4 0.011
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 57 0.011
dendrite development GO:0016358 115 0.011
cilium morphogenesis GO:0060271 102 0.011
cellular response to transforming growth factor beta stimulus GO:0071560 88 0.011
multicellular organism growth GO:0035264 161 0.011
epithelial tube formation GO:0072175 130 0.011
cellular response to organonitrogen compound GO:0071417 145 0.011
muscle system process GO:0003012 141 0.010
spindle checkpoint GO:0031577 12 0.010
anion transport GO:0006820 177 0.010
b cell differentiation GO:0030183 78 0.010
cellular lipid metabolic process GO:0044255 323 0.010
cell cycle g2 m phase transition GO:0044839 20 0.010
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic process GO:0031145 9 0.010
negative regulation of immune system process GO:0002683 209 0.010
response to acid chemical GO:0001101 111 0.010
endocytosis GO:0006897 168 0.010
segmentation GO:0035282 93 0.010
engulfment of apoptotic cell GO:0043652 3 0.010
regulation of metaphase anaphase transition of cell cycle GO:1902099 9 0.010
regulation of leukocyte mediated immunity GO:0002703 104 0.010
response to lipopolysaccharide GO:0032496 128 0.010
embryonic placenta development GO:0001892 98 0.010
placenta development GO:0001890 140 0.010
regulation of neuron apoptotic process GO:0043523 122 0.010

Pot1a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.029
inherited metabolic disorder DOID:655 0 0.029
disease of anatomical entity DOID:7 0 0.021
nervous system disease DOID:863 0 0.021
immune system disease DOID:2914 0 0.019
central nervous system disease DOID:331 0 0.013
disease of cellular proliferation DOID:14566 0 0.013
sensory system disease DOID:0050155 0 0.011
hematopoietic system disease DOID:74 0 0.010
cancer DOID:162 0 0.010