Mus musculus

39 known processes

Prf1

perforin 1 (pore forming protein)

(Aliases: Pfp,Prf-1,Pfn)

Prf1 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.997
negative regulation of inflammatory response to antigenic stimulus GO:0002862 10 0.993
natural killer cell activation GO:0030101 44 0.988
defense response to bacterium GO:0042742 119 0.985
adaptive immune response GO:0002250 155 0.978
leukocyte mediated immunity GO:0002443 174 0.977
natural killer cell mediated cytotoxicity GO:0042267 29 0.971
cell killing GO:0001906 67 0.970
natural killer cell degranulation GO:0043320 3 0.966
lymphocyte mediated immunity GO:0002449 139 0.963
somatic diversification of immune receptors GO:0002200 53 0.955
cell fate commitment GO:0045165 210 0.952
peptidyl tyrosine modification GO:0018212 145 0.950
dna metabolic process GO:0006259 303 0.935
leukocyte proliferation GO:0070661 172 0.929
leukocyte mediated cytotoxicity GO:0001909 62 0.908
cell activation involved in immune response GO:0002263 126 0.895
regulation of leukocyte mediated immunity GO:0002703 104 0.887
regulation of cellular amine metabolic process GO:0033238 20 0.884
cellular ketone metabolic process GO:0042180 84 0.878
natural killer cell mediated immunity GO:0002228 29 0.877
peptidyl tyrosine phosphorylation GO:0018108 143 0.865
leukocyte activation involved in immune response GO:0002366 126 0.839
positive regulation of b cell mediated immunity GO:0002714 26 0.831
somatic diversification of immunoglobulins involved in immune response GO:0002208 36 0.831
lymphocyte proliferation GO:0046651 164 0.819
t cell activation GO:0042110 289 0.815
amine metabolic process GO:0009308 45 0.812
dna recombination GO:0006310 92 0.808
regulation of lymphocyte mediated immunity GO:0002706 84 0.794
t cell mediated immunity GO:0002456 50 0.794
peptidyl amino acid modification GO:0018193 336 0.792
somatic cell dna recombination GO:0016444 51 0.791
negative regulation of lymphocyte activation GO:0051250 91 0.791
epithelial cell proliferation GO:0050673 174 0.790
natural killer cell activation involved in immune response GO:0002323 10 0.785
reactive oxygen species metabolic process GO:0072593 84 0.782
defense response to other organism GO:0098542 197 0.781
regulation of inflammatory response to antigenic stimulus GO:0002861 21 0.775
negative regulation of immune effector process GO:0002698 55 0.774
cellular response to cytokine stimulus GO:0071345 189 0.772
positive regulation of isotype switching to igg isotypes GO:0048304 7 0.770
b cell activation GO:0042113 161 0.765
regulation of peptidyl tyrosine phosphorylation GO:0050730 93 0.762
somatic diversification of immunoglobulins GO:0016445 43 0.750
positive regulation of lymphocyte mediated immunity GO:0002708 62 0.746
somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 51 0.742
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 61 0.722
regulation of dna recombination GO:0000018 34 0.722
regulation of lymphocyte activation GO:0051249 240 0.718
cytokine mediated signaling pathway GO:0019221 115 0.718
somatic recombination of immunoglobulin gene segments GO:0016447 42 0.717
immune effector process GO:0002252 321 0.713
positive regulation of activated t cell proliferation GO:0042104 8 0.709
jak stat cascade GO:0007259 42 0.700
leukocyte homeostasis GO:0001776 79 0.680
regulation of isotype switching GO:0045191 22 0.678
regulation of t cell activation GO:0050863 170 0.672
regulation of b cell activation GO:0050864 81 0.672
negative regulation of inflammatory response GO:0050728 61 0.671
cellular amine metabolic process GO:0044106 44 0.671
immunoglobulin mediated immune response GO:0016064 69 0.667
t cell proliferation GO:0042098 120 0.631
positive regulation of lymphocyte proliferation GO:0050671 70 0.630
response to peptide GO:1901652 136 0.630
cell type specific apoptotic process GO:0097285 268 0.628
lymphocyte activation involved in immune response GO:0002285 93 0.612
leukocyte apoptotic process GO:0071887 71 0.611
t cell differentiation GO:0030217 174 0.605
regulation of leukocyte proliferation GO:0070663 121 0.592
positive regulation of leukocyte mediated immunity GO:0002705 70 0.591
t cell activation involved in immune response GO:0002286 43 0.588
regulation of cell activation GO:0050865 289 0.585
stem cell maintenance GO:0019827 130 0.580
innate immune response GO:0045087 157 0.569
regulation of peptidase activity GO:0052547 96 0.562
negative regulation of interleukin 5 production GO:0032714 4 0.560
regulation of b cell mediated immunity GO:0002712 37 0.559
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 87 0.555
regulation of endopeptidase activity GO:0052548 89 0.546
cytokine biosynthetic process GO:0042089 68 0.543
cellular response to lipid GO:0071396 145 0.541
regulation of lymphocyte differentiation GO:0045619 107 0.539
regulation of interleukin 6 production GO:0032675 55 0.537
leukocyte degranulation GO:0043299 27 0.534
regulation of b cell differentiation GO:0045577 23 0.529
regulation of epithelial cell proliferation GO:0050678 141 0.526
regulation of cellular amino acid metabolic process GO:0006521 5 0.521
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.516
myeloid cell activation involved in immune response GO:0002275 34 0.516
regulation of lymphocyte proliferation GO:0050670 117 0.516
immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 43 0.516
t cell selection GO:0045058 34 0.508
production of molecular mediator of immune response GO:0002440 103 0.505
negative regulation of cell activation GO:0050866 111 0.503
regulation of leukocyte differentiation GO:1902105 159 0.499
homeostasis of number of cells GO:0048872 210 0.492
regulation of cell cycle GO:0051726 281 0.492
isotype switching to igg isotypes GO:0048291 10 0.489
melanocyte differentiation GO:0030318 25 0.489
regulation of interleukin 2 production GO:0032663 28 0.487
positive regulation of protein phosphorylation GO:0001934 242 0.471
myeloid leukocyte mediated immunity GO:0002444 42 0.470
digestive tract development GO:0048565 190 0.469
alpha beta t cell lineage commitment GO:0002363 7 0.468
establishment of melanosome localization GO:0032401 11 0.460
regulation of tolerance induction dependent upon immune response GO:0002652 1 0.450
b cell proliferation GO:0042100 53 0.446
regulation of adaptive immune response GO:0002819 90 0.441
lymphocyte homeostasis GO:0002260 64 0.441
cellular response to biotic stimulus GO:0071216 92 0.441
regulation of angiogenesis GO:0045765 81 0.438
Mouse
regulation of cysteine type endopeptidase activity GO:2000116 65 0.436
regulation of jak stat cascade GO:0046425 34 0.435
positive regulation of leukocyte mediated cytotoxicity GO:0001912 31 0.435
myeloid cell homeostasis GO:0002262 114 0.430
isotype switching GO:0045190 36 0.426
erk1 and erk2 cascade GO:0070371 77 0.425
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.421
positive regulation of interferon gamma production GO:0032729 39 0.421
regulation of cellular ketone metabolic process GO:0010565 66 0.420
positive regulation of production of molecular mediator of immune response GO:0002702 45 0.418
lymphocyte differentiation GO:0030098 242 0.415
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.412
positive regulation of t cell proliferation GO:0042102 52 0.408
somatic recombination of immunoglobulin genes involved in immune response GO:0002204 36 0.406
cd4 positive cd25 positive alpha beta regulatory t cell differentiation GO:0002361 4 0.401
negative regulation of adaptive immune response GO:0002820 25 0.400
cd4 positive alpha beta t cell differentiation GO:0043367 41 0.397
regulation of immunoglobulin mediated immune response GO:0002889 37 0.395
myeloid cell differentiation GO:0030099 233 0.392
natural killer cell proliferation GO:0001787 3 0.390
isotype switching to ige isotypes GO:0048289 7 0.388
negative regulation of defense response GO:0031348 77 0.383
myeloid leukocyte differentiation GO:0002573 119 0.380
immune response activating signal transduction GO:0002757 116 0.374
cellular amino acid metabolic process GO:0006520 103 0.365
regulation of body fluid levels GO:0050878 162 0.362
positive regulation of map kinase activity GO:0043406 84 0.360
regulated secretory pathway GO:0045055 32 0.355
positive regulation of protein modification process GO:0031401 299 0.352
inflammatory response GO:0006954 244 0.345
Mouse
negative regulation of b cell activation GO:0050869 27 0.344
regulation of cytokine biosynthetic process GO:0042035 59 0.340
positive regulation of tumor necrosis factor superfamily cytokine production GO:1903557 31 0.340
urogenital system development GO:0001655 261 0.339
cytokine production GO:0001816 319 0.339
myeloid leukocyte activation GO:0002274 83 0.335
regulation of cytokine production GO:0001817 266 0.331
digestive system development GO:0055123 200 0.329
positive regulation of gamma delta t cell differentiation GO:0045588 6 0.325
gonad development GO:0008406 141 0.322
cellular response to dna damage stimulus GO:0006974 207 0.318
regulation of tyrosine phosphorylation of stat protein GO:0042509 20 0.314
mast cell proliferation GO:0070662 4 0.311
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.309
positive regulation of b cell activation GO:0050871 49 0.306
sphingolipid metabolic process GO:0006665 45 0.306
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 61 0.304
regulation of reactive oxygen species metabolic process GO:2000377 40 0.297
negative regulation of t cell activation GO:0050868 65 0.293
cell chemotaxis GO:0060326 81 0.292
extrinsic apoptotic signaling pathway GO:0097191 126 0.292
t cell differentiation in thymus GO:0033077 77 0.290
positive regulation of mitotic cell cycle GO:0045931 41 0.281
protein maturation GO:0051604 176 0.278
Mouse
cellular lipid metabolic process GO:0044255 323 0.277
positive regulation of cytokine production GO:0001819 174 0.275
cellular response to lipopolysaccharide GO:0071222 77 0.271
v d j recombination GO:0033151 14 0.267
tyrosine phosphorylation of stat protein GO:0007260 23 0.261
regulation of map kinase activity GO:0043405 120 0.255
positive regulation of isotype switching GO:0045830 15 0.252
positive regulation of mapk cascade GO:0043410 170 0.249
growth of symbiont in host GO:0044117 23 0.248
positive regulation of cell cycle GO:0045787 92 0.248
cd4 positive or cd8 positive alpha beta t cell lineage commitment GO:0043369 8 0.247
t helper 1 cell lineage commitment GO:0002296 2 0.241
regulation of innate immune response GO:0045088 91 0.237
positive regulation of dna recombination GO:0045911 17 0.236
negative regulation of chronic inflammatory response GO:0002677 3 0.236
regulation of myeloid leukocyte differentiation GO:0002761 58 0.235
response to radiation GO:0009314 165 0.231
synaptic transmission GO:0007268 329 0.230
t cell lineage commitment GO:0002360 13 0.228
regulation of interferon gamma production GO:0032649 57 0.226
b cell activation involved in immune response GO:0002312 50 0.222
antibacterial humoral response GO:0019731 8 0.218
immunoglobulin production GO:0002377 73 0.218
antibacterial peptide production GO:0002778 2 0.217
positive regulation of tyrosine phosphorylation of stat protein GO:0042531 15 0.215
response to growth factor GO:0070848 198 0.211
response to acid chemical GO:0001101 111 0.207
pattern recognition receptor signaling pathway GO:0002221 47 0.205
regulation of kinase activity GO:0043549 249 0.203
immature b cell differentiation GO:0002327 10 0.202
negative regulation of immune system process GO:0002683 209 0.200
interleukin 6 production GO:0032635 58 0.198
stem cell development GO:0048864 219 0.198
cytokine production involved in immune response GO:0002367 34 0.198
humoral immune response GO:0006959 57 0.198
Mouse
chronic inflammatory response GO:0002544 9 0.197
myeloid cell apoptotic process GO:0033028 22 0.194
melanosome transport GO:0032402 11 0.194
erythrocyte differentiation GO:0030218 88 0.191
regulation of tumor necrosis factor superfamily cytokine production GO:1903555 50 0.190
angiogenesis GO:0001525 201 0.189
Mouse
digestive tract morphogenesis GO:0048546 147 0.189
regulation of t cell differentiation GO:0045580 83 0.189
positive regulation of adaptive immune response GO:0002821 61 0.185
positive regulation of cysteine type endopeptidase activity GO:2001056 39 0.184
response to lipopolysaccharide GO:0032496 128 0.182
positive regulation of lymphocyte activation GO:0051251 140 0.180
positive t cell selection GO:0043368 23 0.179
cardiac muscle cell differentiation GO:0055007 69 0.179
signal transduction in absence of ligand GO:0038034 55 0.178
regulation of isotype switching to ige isotypes GO:0048293 7 0.177
positive regulation of secretion GO:0051047 130 0.170
positive regulation of innate immune response GO:0045089 80 0.168
neutrophil mediated immunity GO:0002446 19 0.166
positive regulation of leukocyte proliferation GO:0070665 73 0.164
positive regulation of isotype switching to ige isotypes GO:0048295 4 0.163
t cell differentiation involved in immune response GO:0002292 30 0.162
positive regulation of cell activation GO:0050867 158 0.161
defense response to gram positive bacterium GO:0050830 50 0.159
inflammatory response to antigenic stimulus GO:0002437 30 0.158
regulation of secretion by cell GO:1903530 249 0.158
t helper cell differentiation GO:0042093 28 0.156
t helper cell lineage commitment GO:0002295 6 0.155
mammary gland epithelial cell proliferation GO:0033598 24 0.154
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 57 0.153
negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 23 0.153
mitotic nuclear division GO:0007067 48 0.152
protein processing GO:0016485 163 0.151
Mouse
response to amino acid GO:0043200 37 0.151
positive regulation of immune effector process GO:0002699 107 0.151
Mouse
cd4 positive alpha beta t cell lineage commitment GO:0043373 6 0.149
exocrine system development GO:0035272 45 0.146
lung development GO:0030324 164 0.145
muscle cell proliferation GO:0033002 52 0.145
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.145
symbiosis encompassing mutualism through parasitism GO:0044403 83 0.144
tumor necrosis factor mediated signaling pathway GO:0033209 13 0.144
positive regulation of protein kinase activity GO:0045860 144 0.143
thymic t cell selection GO:0045061 22 0.142
ameboidal type cell migration GO:0001667 128 0.141
positive regulation of antibacterial peptide biosynthetic process GO:0006963 1 0.140
fertilization GO:0009566 127 0.139
gland development GO:0048732 330 0.138
regulation of protein kinase activity GO:0045859 232 0.137
endocrine system development GO:0035270 98 0.136
t cell homeostasis GO:0043029 35 0.135
regulation of toll like receptor 4 signaling pathway GO:0034143 4 0.135
cellular response to molecule of bacterial origin GO:0071219 83 0.134
positive regulation of kinase activity GO:0033674 155 0.134
cytotoxic t cell degranulation GO:0043316 2 0.134
regulation of mast cell proliferation GO:0070666 4 0.133
response to endoplasmic reticulum stress GO:0034976 53 0.131
extracellular matrix organization GO:0030198 147 0.131
b cell mediated immunity GO:0019724 71 0.130
cellular component assembly involved in morphogenesis GO:0010927 139 0.130
granulocyte activation GO:0036230 10 0.130
regulation of immunoglobulin production GO:0002637 42 0.130
establishment of pigment granule localization GO:0051905 12 0.129
regulation of chronic inflammatory response to antigenic stimulus GO:0002874 3 0.129
regulation of prostaglandin endoperoxide synthase activity GO:0060584 2 0.128
regulation of tyrosine phosphorylation of stat3 protein GO:0042516 10 0.128
activation of mapk activity GO:0000187 59 0.128
regulation of interleukin 5 secretion GO:2000662 2 0.127
positive regulation of proteolysis GO:0045862 85 0.127
microtubule based process GO:0007017 236 0.127
epidermis development GO:0008544 187 0.126
negative regulation of vasculature development GO:1901343 26 0.126
activation of cysteine type endopeptidase activity GO:0097202 27 0.125
positive regulation of protein kinase b signaling GO:0051897 32 0.125
chromatin organization GO:0006325 206 0.125
leukocyte differentiation GO:0002521 342 0.124
positive regulation of inflammatory response to antigenic stimulus GO:0002863 11 0.124
nuclear division GO:0000280 158 0.124
positive regulation of immunoglobulin mediated immune response GO:0002891 26 0.123
response to molecule of bacterial origin GO:0002237 143 0.123
columnar cuboidal epithelial cell differentiation GO:0002065 82 0.123
intracellular protein transport GO:0006886 204 0.122
organelle fission GO:0048285 170 0.121
cellular response to amino acid stimulus GO:0071230 29 0.121
positive regulation of response to wounding GO:1903036 66 0.120
regulation of proteolysis GO:0030162 164 0.120
protein targeting GO:0006605 143 0.120
morphogenesis of a branching epithelium GO:0061138 193 0.119
hindbrain development GO:0030902 128 0.119
leukocyte chemotaxis GO:0030595 69 0.118
positive regulation of cellular amine metabolic process GO:0033240 5 0.118
regulation of mitosis GO:0007088 29 0.118
progesterone metabolic process GO:0042448 4 0.117
positive regulation of immunoglobulin production GO:0002639 28 0.117
positive regulation of reactive oxygen species metabolic process GO:2000379 11 0.115
positive regulation of angiogenesis GO:0045766 46 0.114
Mouse
positive regulation of jak stat cascade GO:0046427 22 0.114
defense response to protozoan GO:0042832 25 0.113
regulation of mapk cascade GO:0043408 248 0.113
regulation of erk1 and erk2 cascade GO:0070372 71 0.113
b cell differentiation GO:0030183 78 0.111
t cell mediated cytotoxicity GO:0001913 26 0.111
response to hydrogen peroxide GO:0042542 32 0.110
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 55 0.109
organelle assembly GO:0070925 177 0.109
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.109
positive regulation of defense response GO:0031349 124 0.109
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 62 0.108
muscle cell development GO:0055001 133 0.107
detection of stimulus GO:0051606 84 0.107
positive regulation of intracellular transport GO:0032388 70 0.106
positive regulation of epithelial cell proliferation GO:0050679 68 0.105
negative regulation of leukocyte differentiation GO:1902106 51 0.105
regulation of mesenchymal cell proliferation GO:0010464 37 0.104
positive regulation of notch signaling pathway GO:0045747 18 0.103
negative regulation of b cell mediated immunity GO:0002713 7 0.103
detection of external stimulus GO:0009581 61 0.102
anatomical structure homeostasis GO:0060249 145 0.102
striated muscle cell development GO:0055002 125 0.101
regulation of inflammatory response GO:0050727 147 0.100
Mouse
regulation of regulated secretory pathway GO:1903305 20 0.099
exocytosis GO:0006887 121 0.099
immune response activating cell surface receptor signaling pathway GO:0002429 72 0.099
regulation of mitotic cell cycle GO:0007346 126 0.098
positive regulation of chemotaxis GO:0050921 38 0.097
macromolecule catabolic process GO:0009057 281 0.096
response to insulin GO:0032868 100 0.096
respiratory system development GO:0060541 190 0.096
stem cell differentiation GO:0048863 268 0.096
inflammatory cell apoptotic process GO:0006925 11 0.095
t helper 2 cell differentiation GO:0045064 12 0.095
regulation of alpha beta t cell differentiation GO:0046637 35 0.095
alpha beta t cell activation GO:0046631 91 0.095
regulation of transferase activity GO:0051338 263 0.093
positive regulation of peptidase activity GO:0010952 49 0.093
positive regulation of cell cycle process GO:0090068 61 0.093
cellular response to growth factor stimulus GO:0071363 197 0.093
regulation of myeloid cell differentiation GO:0045637 96 0.093
response to organic cyclic compound GO:0014070 198 0.092
positive regulation of natural killer cell mediated immunity GO:0002717 16 0.091
antigen receptor mediated signaling pathway GO:0050851 64 0.091
cellular response to fibroblast growth factor stimulus GO:0044344 47 0.091
negative regulation of molecular function GO:0044092 258 0.090
response to oxygen levels GO:0070482 62 0.090
negative regulation of response to wounding GO:1903035 77 0.090
pigment granule localization GO:0051875 13 0.089
positive regulation of myeloid cell differentiation GO:0045639 43 0.089
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 68 0.088
regulation of nuclear division GO:0051783 56 0.086
odontogenesis GO:0042476 78 0.086
membrane lipid metabolic process GO:0006643 53 0.086
cellular macromolecule catabolic process GO:0044265 206 0.086
activation of mapk activity involved in innate immune response GO:0035419 2 0.085
negative regulation of multi organism process GO:0043901 68 0.085
mitotic cell cycle GO:0000278 195 0.085
positive regulation of mitosis GO:0045840 14 0.084
negative regulation of apoptotic signaling pathway GO:2001234 104 0.083
osteoclast differentiation GO:0030316 62 0.083
mucosal associated lymphoid tissue development GO:0048537 12 0.082
regulation of ion transport GO:0043269 215 0.082
positive regulation of endopeptidase activity GO:0010950 43 0.082
alpha beta t cell proliferation GO:0046633 21 0.081
regulation of interleukin 13 secretion GO:2000665 2 0.080
lymph node development GO:0048535 18 0.080
neutrophil apoptotic process GO:0001781 3 0.080
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 45 0.080
rhythmic process GO:0048511 174 0.080
Rat
muscle tissue development GO:0060537 308 0.080
response to interleukin 15 GO:0070672 3 0.079
cellular response to peptide GO:1901653 92 0.079
regulation of toll like receptor 2 signaling pathway GO:0034135 3 0.079
regulation of antigen receptor mediated signaling pathway GO:0050854 29 0.079
prolactin signaling pathway GO:0038161 5 0.078
phosphatidylinositol 3 kinase signaling GO:0014065 36 0.078
positive regulation of t cell differentiation GO:0045582 52 0.078
positive regulation of programmed cell death GO:0043068 218 0.078
regionalization GO:0003002 337 0.076
neutrophil activation GO:0042119 9 0.076
mammary gland lobule development GO:0061377 22 0.075
negative regulation of cellular amine metabolic process GO:0033239 1 0.075
regulation of tumor necrosis factor production GO:0032680 49 0.074
nuclear transport GO:0051169 139 0.074
positive regulation of mesenchymal cell proliferation GO:0002053 33 0.074
chemotaxis GO:0006935 247 0.074
establishment of protein localization to organelle GO:0072594 118 0.073
positive regulation of stress activated mapk cascade GO:0032874 48 0.072
skin development GO:0043588 220 0.072
regulation of production of molecular mediator of immune response GO:0002700 65 0.071
negative regulation of hypersensitivity GO:0002884 3 0.071
positive regulation of translational initiation GO:0045948 4 0.071
positive regulation of t cell activation GO:0050870 101 0.070
interleukin 10 secretion GO:0072608 4 0.070
negative regulation of epithelial cell proliferation GO:0050680 64 0.069
regulation of jun kinase activity GO:0043506 40 0.069
t cell receptor signaling pathway GO:0050852 46 0.069
regulation of protein complex assembly GO:0043254 83 0.069
positive regulation of behavior GO:0048520 40 0.069
endodermal cell fate specification GO:0001714 4 0.069
negative regulation of myeloid cell apoptotic process GO:0033033 11 0.068
regulation of cell cycle process GO:0010564 160 0.068
response to protozoan GO:0001562 28 0.068
positive regulation of apoptotic process GO:0043065 217 0.067
smooth muscle tissue development GO:0048745 22 0.066
nucleic acid phosphodiester bond hydrolysis GO:0090305 49 0.066
positive regulation of b cell differentiation GO:0045579 13 0.066
negative regulation of cell proliferation GO:0008285 296 0.065
pigment granule transport GO:0051904 12 0.065
regulation of alpha beta t cell activation GO:0046634 53 0.065
regulation of chemotaxis GO:0050920 53 0.064
regulation of hydrolase activity GO:0051336 246 0.064
pigment cell differentiation GO:0050931 27 0.064
organ or tissue specific immune response GO:0002251 13 0.064
positive regulation of cytokine biosynthetic process GO:0042108 40 0.063
eosinophil activation GO:0043307 1 0.062
cellular response to steroid hormone stimulus GO:0071383 33 0.062
apoptotic signaling pathway GO:0097190 306 0.062
lung cell differentiation GO:0060479 30 0.062
glycolipid metabolic process GO:0006664 25 0.062
inositol lipid mediated signaling GO:0048017 41 0.061
detection of abiotic stimulus GO:0009582 60 0.061
negative regulation of growth of symbiont in host GO:0044130 19 0.060
regulation of secretion GO:0051046 274 0.060
modulation of growth of symbiont involved in interaction with host GO:0044144 19 0.060
liposaccharide metabolic process GO:1903509 27 0.060
respiratory tube development GO:0030323 167 0.060
regulation of neuron projection development GO:0010975 169 0.059
alpha beta t cell differentiation GO:0046632 69 0.059
positive regulation of leukocyte differentiation GO:1902107 86 0.059
regulation of acute inflammatory response GO:0002673 27 0.059
Mouse
positive regulation of transferase activity GO:0051347 167 0.058
sulfur compound metabolic process GO:0006790 100 0.058
regulation of lipid metabolic process GO:0019216 118 0.058
cell division GO:0051301 120 0.058
immune response regulating cell surface receptor signaling pathway GO:0002768 80 0.058
positive regulation of tyrosine phosphorylation of stat5 protein GO:0042523 6 0.058
sensory organ morphogenesis GO:0090596 242 0.058
striated muscle tissue development GO:0014706 293 0.058
positive regulation of interleukin 12 production GO:0032735 21 0.058
positive regulation of mhc class ii biosynthetic process GO:0045348 4 0.057
regulation of defense response GO:0031347 233 0.057
Mouse
embryonic organ morphogenesis GO:0048562 276 0.057
single fertilization GO:0007338 82 0.057
regulation of myeloid cell apoptotic process GO:0033032 19 0.057
cytokine metabolic process GO:0042107 71 0.056
single organism cell adhesion GO:0098602 156 0.056
negative regulation of hydrolase activity GO:0051346 71 0.056
negative regulation of protein maturation GO:1903318 79 0.056
phosphatidylinositol mediated signaling GO:0048015 41 0.055
muscle cell differentiation GO:0042692 261 0.055
regulation of vasculature development GO:1901342 88 0.055
Mouse
learning or memory GO:0007611 148 0.054
negative regulation of myeloid dendritic cell activation GO:0030886 3 0.054
transmembrane transport GO:0055085 412 0.054
interleukin 1 production GO:0032612 31 0.053
positive regulation of interleukin 2 biosynthetic process GO:0045086 8 0.053
protein kinase b signaling GO:0043491 74 0.053
nucleocytoplasmic transport GO:0006913 139 0.053
nucleotide metabolic process GO:0009117 332 0.053
organic hydroxy compound metabolic process GO:1901615 203 0.053
development of primary female sexual characteristics GO:0046545 73 0.053
negative regulation of interleukin 2 biosynthetic process GO:0045085 3 0.053
negative regulation of toll like receptor signaling pathway GO:0034122 14 0.053
histone lysine methylation GO:0034968 50 0.052
negative regulation of interleukin 6 production GO:0032715 17 0.052
regulation of chronic inflammatory response GO:0002676 7 0.052
positive regulation of regulatory t cell differentiation GO:0045591 4 0.052
regulation of vesicle mediated transport GO:0060627 139 0.052
immune response regulating signaling pathway GO:0002764 125 0.051
skeletal muscle organ development GO:0060538 163 0.051
negative regulation of type 2 immune response GO:0002829 8 0.050
regulation of growth of symbiont in host GO:0044126 19 0.050
interleukin 2 biosynthetic process GO:0042094 15 0.050
face development GO:0060324 38 0.050
positive regulation of cell death GO:0010942 224 0.050
regulation of b cell proliferation GO:0030888 39 0.049
positive regulation of alpha beta t cell activation GO:0046635 39 0.049
lung alveolus development GO:0048286 45 0.049
protein acylation GO:0043543 64 0.049
regulation of cell division GO:0051302 76 0.049
mast cell activation GO:0045576 27 0.049
negative regulation of interleukin 2 production GO:0032703 8 0.049
negative regulation of leukocyte proliferation GO:0070664 46 0.048

Prf1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.667
Human
disease of cellular proliferation DOID:14566 0 0.667
Human
organ system cancer DOID:0050686 0 0.667
Human
immune system disease DOID:2914 0 0.274
Human
disease of anatomical entity DOID:7 0 0.274
Human
disease of metabolism DOID:0014667 0 0.131
carbohydrate metabolism disease DOID:0050013 0 0.131
glucose metabolism disease DOID:4194 0 0.131
acquired metabolic disease DOID:0060158 0 0.131
immune system cancer DOID:0060083 0 0.123
Human
hematologic cancer DOID:2531 0 0.123
Human
diabetes mellitus DOID:9351 0 0.071