Mus musculus

177 known processes

Prkdc

protein kinase, DNA activated, catalytic polypeptide

(Aliases: DNAPK,HYRC1,AI326420,slip,DNPK1,dxnph,DNAPDcs,scid,AU019811,p460,DOXNPH,XRCC7,DNA-PKcs)

Prkdc biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
dna recombination GO:0006310 92 1.000
v d j recombination GO:0033151 14 0.999
telomere capping GO:0016233 4 0.999
dna repair GO:0006281 107 0.998
dna metabolic process GO:0006259 303 0.995
somatic cell dna recombination GO:0016444 51 0.992
cellular hyperosmotic salinity response GO:0071475 0 0.991
b cell differentiation GO:0030183 78 0.976
somatic recombination of immunoglobulin gene segments GO:0016447 42 0.973
somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 51 0.967
cellular response to dna damage stimulus GO:0006974 207 0.962
double strand break repair GO:0006302 48 0.958
immature b cell differentiation GO:0002327 10 0.942
non recombinational repair GO:0000726 10 0.939
somatic diversification of immunoglobulins involved in immune response GO:0002208 36 0.937
response to x ray GO:0010165 11 0.934
telomere maintenance GO:0000723 19 0.931
leukocyte differentiation GO:0002521 342 0.931
cellular response to gamma radiation GO:0071480 4 0.925
somatic diversification of immune receptors GO:0002200 53 0.879
immunoglobulin production GO:0002377 73 0.861
b cell activation GO:0042113 161 0.759
positive regulation of gene silencing by mirna GO:2000637 1 0.740
response to ionizing radiation GO:0010212 42 0.718
positive regulation of cell development GO:0010720 237 0.672
b cell activation involved in immune response GO:0002312 50 0.592
adaptive immune response GO:0002250 155 0.560
reciprocal dna recombination GO:0035825 16 0.554
immunoglobulin mediated immune response GO:0016064 69 0.519
cellular response to radiation GO:0071478 28 0.513
positive regulation of protein oligomerization GO:0032461 4 0.501
somatic diversification of t cell receptor genes GO:0002568 5 0.477
negative regulation of neuron death GO:1901215 98 0.456
regulation of chromosome organization GO:0033044 83 0.419
intra s dna damage checkpoint GO:0031573 4 0.409
somatic recombination of immunoglobulin genes involved in immune response GO:0002204 36 0.407
signal transduction involved in mitotic dna damage checkpoint GO:1902402 3 0.400
gene silencing GO:0016458 38 0.393
spleen development GO:0048536 39 0.378
histone h4 k16 acetylation GO:0043984 3 0.349
chromatin organization GO:0006325 206 0.346
anatomical structure homeostasis GO:0060249 145 0.337
lymphocyte differentiation GO:0030098 242 0.337
meiotic nuclear division GO:0007126 115 0.322
chromatin silencing GO:0006342 15 0.320
cellular nitrogen compound catabolic process GO:0044270 280 0.318
regulation of neuron apoptotic process GO:0043523 122 0.316
meiotic cell cycle process GO:1903046 77 0.316
nucleic acid phosphodiester bond hydrolysis GO:0090305 49 0.314
nucleotide excision repair GO:0006289 13 0.310
organic cyclic compound catabolic process GO:1901361 295 0.307
t cell receptor v d j recombination GO:0033153 5 0.303
double strand break repair via nonhomologous end joining GO:0006303 10 0.295
covalent chromatin modification GO:0016569 163 0.291
lymphocyte homeostasis GO:0002260 64 0.280
dna catabolic process GO:0006308 19 0.267
immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 43 0.263
replicative senescence GO:0090399 2 0.260
t cell homeostasis GO:0043029 35 0.259
regulation of cellular ketone metabolic process GO:0010565 66 0.252
response to purine containing compound GO:0014074 28 0.234
aromatic compound catabolic process GO:0019439 286 0.232
signal transduction involved in dna integrity checkpoint GO:0072401 3 0.232
dna damage response signal transduction resulting in transcription GO:0042772 2 0.226
isotype switching GO:0045190 36 0.219
t cell apoptotic process GO:0070231 39 0.217
somatic recombination of t cell receptor gene segments GO:0002681 5 0.217
internal protein amino acid acetylation GO:0006475 42 0.213
protein modification by small protein conjugation GO:0032446 187 0.204
positive regulation of histone h3 k9 methylation GO:0051574 4 0.203
dendrite regeneration GO:0031104 1 0.200
protection from non homologous end joining at telomere GO:0031848 4 0.199
immunoglobulin v d j recombination GO:0033152 5 0.195
protein maturation GO:0051604 176 0.192
cell type specific apoptotic process GO:0097285 268 0.189
leukocyte apoptotic process GO:0071887 71 0.181
pre b cell differentiation GO:0002329 7 0.176
phosphatidylinositol biosynthetic process GO:0006661 15 0.174
meiotic chromosome segregation GO:0045132 19 0.172
gene silencing by mirna GO:0035195 10 0.162
monocarboxylic acid metabolic process GO:0032787 191 0.162
cell activation involved in immune response GO:0002263 126 0.161
dna damage response signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 2 0.160
dna catabolic process exonucleolytic GO:0000738 3 0.159
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 57 0.157
negative regulation of epithelial cell proliferation GO:0050680 64 0.154
meiotic cell cycle GO:0051321 122 0.152
phosphatidylinositol metabolic process GO:0046488 45 0.147
male gamete generation GO:0048232 285 0.145
response to uv GO:0009411 44 0.142
protein modification by small protein conjugation or removal GO:0070647 207 0.142
positive regulation of neuron death GO:1901216 28 0.136
regulation of b cell differentiation GO:0045577 23 0.132
regulation of mitotic cell cycle phase transition GO:1901990 73 0.129
regulation of organelle organization GO:0033043 289 0.127
lymphocyte activation involved in immune response GO:0002285 93 0.124
cellular response to ionizing radiation GO:0071479 11 0.121
regulation of reactive oxygen species metabolic process GO:2000377 40 0.119
macromolecule catabolic process GO:0009057 281 0.119
dna methylation GO:0006306 43 0.118
neuron apoptotic process GO:0051402 142 0.118
peptidyl serine modification GO:0018209 83 0.116
alpha beta t cell differentiation GO:0046632 69 0.116
negative regulation of cellular amine metabolic process GO:0033239 1 0.112
chromatin modification GO:0016568 187 0.112
positive regulation of protein homooligomerization GO:0032464 3 0.110
telomere maintenance in response to dna damage GO:0043247 4 0.108
phosphatidylinositol 3 phosphate biosynthetic process GO:0036092 6 0.107
schwann cell proliferation GO:0014010 2 0.106
leukocyte homeostasis GO:0001776 79 0.104
nuclear division GO:0000280 158 0.104
histone mrna metabolic process GO:0008334 3 0.103
reciprocal meiotic recombination GO:0007131 16 0.103
response to uv b GO:0010224 5 0.103
microtubule based process GO:0007017 236 0.103
response to organic cyclic compound GO:0014070 198 0.102
response to radiation GO:0009314 165 0.102
b cell homeostatic proliferation GO:0002358 2 0.101
regulation of mitotic cell cycle GO:0007346 126 0.099
negative regulation of cell proliferation GO:0008285 296 0.099
organophosphate biosynthetic process GO:0090407 122 0.098
negative regulation of homeostatic process GO:0032845 71 0.097
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.096
pre mirna processing GO:0031054 3 0.095
meiosis i GO:0007127 60 0.095
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.095
negative regulation of dna replication GO:0008156 4 0.094
response to organonitrogen compound GO:0010243 246 0.094
thymocyte apoptotic process GO:0070242 19 0.093
response to inorganic substance GO:0010035 96 0.093
cellular amine metabolic process GO:0044106 44 0.093
response to gamma radiation GO:0010332 22 0.092
rna catabolic process GO:0006401 29 0.090
glial cell apoptotic process GO:0034349 3 0.090
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.089
spermatogenesis GO:0007283 284 0.089
positive regulation of neuron apoptotic process GO:0043525 25 0.088
response to alkaloid GO:0043279 34 0.087
positive regulation of chromosome organization GO:2001252 33 0.086
t cell differentiation in thymus GO:0033077 77 0.083
protein autophosphorylation GO:0046777 61 0.082
mitotic g1 dna damage checkpoint GO:0031571 4 0.081
female sex differentiation GO:0046660 84 0.079
fertilization GO:0009566 127 0.078
leukocyte activation involved in immune response GO:0002366 126 0.078
positive regulation of apoptotic process involved in mammary gland involution GO:0060058 4 0.078
peptidyl amino acid modification GO:0018193 336 0.077
negative regulation of lymphocyte apoptotic process GO:0070229 24 0.077
cellular response to abiotic stimulus GO:0071214 56 0.076
cd4 positive cd25 positive alpha beta regulatory t cell differentiation GO:0002361 4 0.076
regulation of histone modification GO:0031056 56 0.074
phospholipid metabolic process GO:0006644 87 0.074
apoptotic signaling pathway GO:0097190 306 0.074
retina homeostasis GO:0001895 23 0.073
signal transduction involved in mitotic cell cycle checkpoint GO:0072413 3 0.073
regulation of neuron death GO:1901214 134 0.073
positive regulation of histone modification GO:0031058 28 0.073
regulation of histone h3 k9 methylation GO:0051570 8 0.072
regulation of t cell apoptotic process GO:0070232 28 0.071
leukocyte mediated immunity GO:0002443 174 0.071
negative regulation of mammary gland epithelial cell proliferation GO:0033600 3 0.071
positive regulation of b cell differentiation GO:0045579 13 0.070
forebrain development GO:0030900 302 0.069
positive regulation of nervous system development GO:0051962 221 0.068
cytoplasmic pattern recognition receptor signaling pathway in response to virus GO:0039528 4 0.067
skeletal system development GO:0001501 356 0.066
amine metabolic process GO:0009308 45 0.065
dna catabolic process endonucleolytic GO:0000737 15 0.065
pro b cell differentiation GO:0002328 10 0.063
cellular response to x ray GO:0071481 2 0.063
positive regulation of posttranscriptional gene silencing GO:0060148 1 0.063
regulation of protein homooligomerization GO:0032462 3 0.062
intrinsic apoptotic signaling pathway GO:0097193 132 0.062
endodermal cell fate specification GO:0001714 4 0.061
nucleoside monophosphate metabolic process GO:0009123 85 0.061
limb development GO:0060173 166 0.061
heterocycle catabolic process GO:0046700 280 0.061
regulation of lymphocyte differentiation GO:0045619 107 0.061
b cell mediated immunity GO:0019724 71 0.060
reactive oxygen species metabolic process GO:0072593 84 0.060
organelle fission GO:0048285 170 0.060
male meiosis i GO:0007141 16 0.060
peptidyl serine phosphorylation GO:0018105 74 0.060
purine ribonucleoside metabolic process GO:0046128 241 0.059
mrna 3 end processing GO:0031124 16 0.059
purine nucleotide metabolic process GO:0006163 302 0.058
t cell differentiation GO:0030217 174 0.057
glycerophospholipid metabolic process GO:0006650 71 0.057
dna damage checkpoint GO:0000077 26 0.056
schwann cell differentiation GO:0014037 26 0.056
recombinational repair GO:0000725 21 0.055
extrinsic apoptotic signaling pathway GO:0097191 126 0.055
positive regulation of gamma delta t cell differentiation GO:0045588 6 0.055
regulation of cellular component biogenesis GO:0044087 181 0.055
stem cell development GO:0048864 219 0.055
neuron death GO:0070997 154 0.055
production of molecular mediator of immune response GO:0002440 103 0.055
regulation of membrane potential GO:0042391 192 0.055
protein acylation GO:0043543 64 0.054
positive regulation of chromatin modification GO:1903310 28 0.054
protein processing GO:0016485 163 0.053
regulation of calcium ion transport into cytosol GO:0010522 31 0.053
cellular lipid metabolic process GO:0044255 323 0.053
histone modification GO:0016570 159 0.053
hyperosmotic salinity response GO:0042538 1 0.052
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.052
cell cycle checkpoint GO:0000075 47 0.051
columnar cuboidal epithelial cell differentiation GO:0002065 82 0.051
nucleoside metabolic process GO:0009116 246 0.050
appendage development GO:0048736 166 0.050
purine containing compound metabolic process GO:0072521 311 0.049
glycerolipid metabolic process GO:0046486 122 0.049
negative regulation of mitotic cell cycle phase transition GO:1901991 45 0.049
rna processing GO:0006396 105 0.048
gonad development GO:0008406 141 0.048
muscle tissue development GO:0060537 308 0.048
regulation of chromatin modification GO:1903308 57 0.048
regulation of protein oligomerization GO:0032459 4 0.048
response to extracellular stimulus GO:0009991 127 0.048
telomere maintenance via telomerase GO:0007004 1 0.047
negative regulation of mitotic cell cycle GO:0045930 58 0.047
central nervous system neuron differentiation GO:0021953 162 0.047
lymphocyte apoptotic process GO:0070227 54 0.047
regulation of cysteine type endopeptidase activity GO:2000116 65 0.047
positive regulation of mitotic sister chromatid separation GO:1901970 2 0.047
long term synaptic potentiation GO:0060291 25 0.046
regulation of cell cycle phase transition GO:1901987 77 0.046
fibroblast proliferation GO:0048144 35 0.046
adherens junction organization GO:0034332 28 0.046
positive regulation of glial cell proliferation GO:0060252 4 0.046
cellular response to water stimulus GO:0071462 1 0.045
rig i signaling pathway GO:0039529 4 0.045
regulation of epithelial cell proliferation GO:0050678 141 0.045
action potential GO:0001508 78 0.045
organ growth GO:0035265 117 0.045
cellular response to organic cyclic compound GO:0071407 87 0.045
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 55 0.045
carbohydrate derivative biosynthetic process GO:1901137 183 0.044
lipid biosynthetic process GO:0008610 179 0.044
negative regulation of synapse assembly GO:0051964 3 0.044
positive regulation of growth GO:0045927 104 0.044
negative regulation of neuron apoptotic process GO:0043524 92 0.043
regulation of cell cycle GO:0051726 281 0.043
negative regulation of protein metabolic process GO:0051248 282 0.043
regulation of hydrolase activity GO:0051336 246 0.043
ribonucleoside monophosphate catabolic process GO:0009158 57 0.043
innate immune response GO:0045087 157 0.043
t helper cell differentiation GO:0042093 28 0.043
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.042
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 34 0.042
multicellular organism growth GO:0035264 161 0.042
chromosome segregation GO:0007059 48 0.042
rna phosphodiester bond hydrolysis GO:0090501 19 0.042
atp metabolic process GO:0046034 75 0.042
cell aging GO:0007569 35 0.042
regulation of response to dna damage stimulus GO:2001020 34 0.041
positive regulation of release of cytochrome c from mitochondria GO:0090200 5 0.041
regulation of leukocyte apoptotic process GO:2000106 56 0.041
positive regulation of protein autophosphorylation GO:0031954 4 0.041
regulation of alpha beta t cell differentiation GO:0046637 35 0.040
mrna metabolic process GO:0016071 84 0.040
development of primary sexual characteristics GO:0045137 143 0.040
negative regulation of b cell proliferation GO:0030889 13 0.040
rhythmic process GO:0048511 174 0.039
regulation of b cell proliferation GO:0030888 39 0.039
signal transduction involved in mitotic dna integrity checkpoint GO:1902403 3 0.039
positive regulation of regulatory t cell differentiation GO:0045591 4 0.039
dna dependent dna replication GO:0006261 24 0.039
regulation of androgen receptor signaling pathway GO:0060765 3 0.039
regulation of mitochondrial membrane permeability GO:0046902 17 0.039
fatty acid metabolic process GO:0006631 121 0.038
cytoplasmic transport GO:0016482 234 0.037
lymphocyte proliferation GO:0046651 164 0.037
positive regulation of lymphocyte apoptotic process GO:0070230 13 0.036
somatic hypermutation of immunoglobulin genes GO:0016446 7 0.036
calcium ion transport GO:0006816 159 0.036
regulation of protein localization GO:0032880 231 0.036
negative regulation of b cell activation GO:0050869 27 0.036
organonitrogen compound catabolic process GO:1901565 264 0.036
nuclear transcribed mrna catabolic process GO:0000956 16 0.036
base excision repair GO:0006284 9 0.036
ear development GO:0043583 200 0.035
response to testosterone GO:0033574 3 0.035
response to starvation GO:0042594 65 0.034
signal transduction in absence of ligand GO:0038034 55 0.034
purine ribonucleotide metabolic process GO:0009150 290 0.034
positive regulation of transcription by galactose GO:0000411 1 0.034
urogenital system development GO:0001655 261 0.034
negative regulation of histone methylation GO:0031061 10 0.034
mitochondrial dna repair GO:0043504 3 0.034
mitotic cell cycle checkpoint GO:0007093 31 0.034
negative regulation of dna dependent dna replication GO:2000104 1 0.034
regulation of mitosis GO:0007088 29 0.034
dna damage response signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 3 0.034
positive regulation of proteolysis GO:0045862 85 0.034
regulation of muscle cell apoptotic process GO:0010660 17 0.033
glycerophospholipid biosynthetic process GO:0046474 32 0.032
metaphase plate congression GO:0051310 2 0.032
mitochondrial outer membrane permeabilization involved in programmed cell death GO:1902686 11 0.032
cellular ion homeostasis GO:0006873 165 0.032
phospholipid biosynthetic process GO:0008654 36 0.032
cell fate commitment GO:0045165 210 0.032
cellular response to steroid hormone stimulus GO:0071383 33 0.032
divalent metal ion transport GO:0070838 172 0.031
sister chromatid cohesion GO:0007062 12 0.031
somitogenesis GO:0001756 69 0.031
regulation of lymphocyte apoptotic process GO:0070228 41 0.031
apoptotic process involved in mammary gland involution GO:0060057 4 0.031
ribonucleoside monophosphate metabolic process GO:0009161 80 0.031
response to oxidative stress GO:0006979 123 0.031
negative regulation of protein phosphorylation GO:0001933 126 0.031
nucleobase containing compound transport GO:0015931 27 0.031
microtubule cytoskeleton organization GO:0000226 157 0.031
regulation of histone h3 k4 methylation GO:0051569 12 0.031
cellularization GO:0007349 1 0.031
fatty acid biosynthetic process GO:0006633 41 0.031
negative regulation of histone h3 k9 methylation GO:0051573 4 0.030
glycosyl compound metabolic process GO:1901657 246 0.030
intracellular signal transduction involved in g1 dna damage checkpoint GO:1902400 3 0.030
metal ion homeostasis GO:0055065 189 0.030
somatic diversification of immune receptors via somatic mutation GO:0002566 8 0.030
immune effector process GO:0002252 321 0.030
positive regulation of mesoderm development GO:2000382 2 0.030
peptidyl lysine acetylation GO:0018394 45 0.029
metaphase anaphase transition of mitotic cell cycle GO:0007091 9 0.029
fibroblast apoptotic process GO:0044346 9 0.029
negative regulation of apoptotic signaling pathway GO:2001234 104 0.029
rna phosphodiester bond hydrolysis endonucleolytic GO:0090502 10 0.029
positive regulation of histone h3 k4 methylation GO:0051571 5 0.029
negative regulation of innate immune response GO:0045824 17 0.029
regulation of fibroblast proliferation GO:0048145 34 0.029
zygote asymmetric cell division GO:0010070 2 0.029
b cell lineage commitment GO:0002326 4 0.029
dna biosynthetic process GO:0071897 22 0.029
negative regulation of organ growth GO:0046621 17 0.028
dna replication checkpoint GO:0000076 2 0.028
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.028
positive regulation of mirna metabolic process GO:2000630 1 0.028
posttranscriptional gene silencing GO:0016441 10 0.028
regulation of cell division GO:0051302 76 0.028
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.027
positive regulation of dna templated transcription elongation GO:0032786 2 0.027
regulation of rig i signaling pathway GO:0039535 2 0.027
thymus development GO:0048538 41 0.027
neuronal action potential GO:0019228 54 0.027
mitotic recombination GO:0006312 3 0.027
positive regulation of cysteine type endopeptidase activity GO:2001056 39 0.027
regulation of b cell activation GO:0050864 81 0.027
rna 3 end processing GO:0031123 20 0.027
multicellular organismal signaling GO:0035637 91 0.027
male sex differentiation GO:0046661 109 0.027
negative regulation of phosphatidylinositol 3 kinase activity GO:0043553 1 0.027
purine nucleoside monophosphate metabolic process GO:0009126 81 0.027
negative regulation of cell cycle GO:0045786 123 0.027
appendage morphogenesis GO:0035107 149 0.027
muscle cell apoptotic process GO:0010657 18 0.026
t cell activation GO:0042110 289 0.026
mitotic spindle assembly checkpoint GO:0007094 7 0.026
segmentation GO:0035282 93 0.026
cellular response to increased oxygen levels GO:0036295 1 0.026
negative regulation of anoikis GO:2000811 2 0.026
response to drug GO:0042493 75 0.026
response to oxygen levels GO:0070482 62 0.026
regulation of lymphocyte activation GO:0051249 240 0.026
gene silencing by rna GO:0031047 19 0.025
signal transduction in response to dna damage GO:0042770 21 0.025
regulation of chromatin organization GO:1902275 57 0.025
cellular response to organonitrogen compound GO:0071417 145 0.025
lipoprotein catabolic process GO:0042159 7 0.025
positive regulation of response to dna damage stimulus GO:2001022 14 0.025
photoreceptor cell maintenance GO:0045494 19 0.025
activation of cysteine type endopeptidase activity involved in apoptotic signaling pathway GO:0097296 2 0.025
myelination GO:0042552 74 0.025
cellular response to starvation GO:0009267 57 0.024
peripheral nervous system development GO:0007422 53 0.024
protein catabolic process GO:0030163 221 0.024
regulation of cellular amino acid metabolic process GO:0006521 5 0.024
calcium ion homeostasis GO:0055074 127 0.024
regionalization GO:0003002 337 0.024
regulation of peptidyl serine phosphorylation GO:0033135 39 0.024
regulation of cell growth GO:0001558 91 0.024
regulation of histone acetylation GO:0035065 19 0.024
positive regulation of metaphase anaphase transition of cell cycle GO:1902101 2 0.023
regulation of cellular response to stress GO:0080135 159 0.023
sequestering of calcium ion GO:0051208 18 0.023
protein depolymerization GO:0051261 34 0.023
germ line stem cell division GO:0042078 2 0.023
positive regulation of programmed cell death GO:0043068 218 0.023
mitotic sister chromatid separation GO:0051306 9 0.023
cellular process regulating host cell cycle in response to virus GO:0060154 3 0.023
response to peptide hormone GO:0043434 127 0.023
nucleic acid transport GO:0050657 18 0.022
cellular response to decreased oxygen levels GO:0036294 18 0.022
negative regulation of protein depolymerization GO:1901880 21 0.022
negative regulation of oxidative stress induced intrinsic apoptotic signaling pathway GO:1902176 4 0.022
dna geometric change GO:0032392 7 0.022
negative regulation of cell growth GO:0030308 44 0.022
modulation by virus of host morphology or physiology GO:0019048 3 0.022
single fertilization GO:0007338 82 0.022
cellular macromolecule catabolic process GO:0044265 206 0.022
negative regulation of proteolysis GO:0045861 74 0.022
glial cell development GO:0021782 54 0.022
negative regulation of cell size GO:0045792 3 0.022
mitotic sister chromatid cohesion GO:0007064 1 0.022
regulation of mitotic sister chromatid segregation GO:0033047 12 0.022
generation of precursor metabolites and energy GO:0006091 103 0.021
blastocyst development GO:0001824 80 0.021
b cell apoptotic process GO:0001783 19 0.021
dna ligation GO:0006266 3 0.021
positive regulation of myelination GO:0031643 5 0.021
negative regulation of cellular protein catabolic process GO:1903363 22 0.021
mrna catabolic process GO:0006402 22 0.021
atp catabolic process GO:0006200 55 0.021
regulation of mrna stability GO:0043488 23 0.021
oocyte differentiation GO:0009994 35 0.021
positive regulation of neuron differentiation GO:0045666 141 0.021
regulation of homeostatic process GO:0032844 182 0.021
nucleoside triphosphate metabolic process GO:0009141 230 0.020
inner ear receptor cell differentiation GO:0060113 61 0.020
cellular hyperosmotic response GO:0071474 0 0.020
postreplication repair GO:0006301 5 0.020
bmp signaling pathway GO:0030509 93 0.020
cellular carbohydrate metabolic process GO:0044262 119 0.020
intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 19 0.020
negative regulation of gene expression epigenetic GO:0045814 15 0.020
rna localization GO:0006403 23 0.020
viral process GO:0016032 41 0.020
negative regulation of lipid kinase activity GO:0090219 1 0.020
positive regulation of mammary gland involution GO:1903521 4 0.020
regulation of cell cycle g2 m phase transition GO:1902749 10 0.020
cell division GO:0051301 120 0.020
response to steroid hormone GO:0048545 56 0.020
regulation of ion homeostasis GO:2000021 64 0.020
telencephalon development GO:0021537 186 0.020
positive regulation of apoptotic process involved in morphogenesis GO:1902339 4 0.019
positive regulation of mitotic cell cycle GO:0045931 41 0.019
mesenchyme development GO:0060485 152 0.019
organelle assembly GO:0070925 177 0.019
maintenance of location GO:0051235 89 0.019
mitochondrial membrane organization GO:0007006 26 0.019
response to temperature stimulus GO:0009266 55 0.019
hair follicle morphogenesis GO:0031069 29 0.019
cellular response to inorganic substance GO:0071241 37 0.019
purine nucleoside monophosphate catabolic process GO:0009128 58 0.019
cellular response to light stimulus GO:0071482 19 0.019
glycerolipid biosynthetic process GO:0045017 50 0.019
negative regulation of schwann cell proliferation GO:0010626 1 0.019
embryonic limb morphogenesis GO:0030326 126 0.019
carbohydrate metabolic process GO:0005975 230 0.019
cellular metal ion homeostasis GO:0006875 151 0.019
negative regulation of thymocyte apoptotic process GO:0070244 8 0.019
divalent inorganic cation transport GO:0072511 178 0.019
positive regulation of leukocyte apoptotic process GO:2000108 21 0.019
positive regulation of cellular amine metabolic process GO:0033240 5 0.019
dna conformation change GO:0071103 37 0.019

Prkdc disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.959
disease of cellular proliferation DOID:14566 0 0.959
organ system cancer DOID:0050686 0 0.959
immune system disease DOID:2914 0 0.924
disease of anatomical entity DOID:7 0 0.924
immune system cancer DOID:0060083 0 0.743
hematologic cancer DOID:2531 0 0.743
endocrine gland cancer DOID:170 0 0.549
thoracic cancer DOID:5093 0 0.505
primary immunodeficiency disease DOID:612 0 0.334
thyroid cancer DOID:1781 0 0.148
breast cancer DOID:1612 0 0.103
prostate cancer DOID:10283 0 0.089
male reproductive organ cancer DOID:3856 0 0.089
reproductive organ cancer DOID:193 0 0.089
congenital hypoplastic anemia DOID:1342 0 0.082
aplastic anemia DOID:12449 0 0.082
bone marrow disease DOID:4961 0 0.082
anemia DOID:2355 0 0.082
hematopoietic system disease DOID:74 0 0.082
pancreatic cancer DOID:1793 0 0.081
nervous system disease DOID:863 0 0.077
large intestine cancer DOID:5672 0 0.049
colon cancer DOID:219 0 0.049
gastrointestinal system cancer DOID:3119 0 0.049
intestinal cancer DOID:10155 0 0.049
colorectal cancer DOID:9256 0 0.049
endocrine system disease DOID:28 0 0.046
bone marrow cancer DOID:4960 0 0.035
blood protein disease DOID:620 0 0.026
agammaglobulinemia DOID:2583 0 0.026
common variable immunodeficiency DOID:12177 0 0.026
b cell deficiency DOID:2115 0 0.026
combined t cell and b cell immunodeficiency DOID:628 0 0.023
respiratory system cancer DOID:0050615 0 0.023
lung cancer DOID:1324 0 0.023
liver carcinoma DOID:686 0 0.021
liver cancer DOID:3571 0 0.021
disease of metabolism DOID:0014667 0 0.021