Mus musculus

30 known processes

Psma1

proteasome (prosome, macropain) subunit, alpha type 1

(Aliases: HC2,C2,alpha-type,Pros-30)

Psma1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
modification dependent macromolecule catabolic process GO:0043632 133 0.991
Yeast
proteasomal ubiquitin independent protein catabolic process GO:0010499 1 0.988
Yeast
cellular protein catabolic process GO:0044257 155 0.973
Yeast
cellular macromolecule catabolic process GO:0044265 206 0.967
Yeast
ubiquitin dependent protein catabolic process GO:0006511 129 0.947
Yeast
modification dependent protein catabolic process GO:0019941 133 0.887
Yeast
proteasomal protein catabolic process GO:0010498 98 0.844
Yeast
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.842
Yeast
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.826
Yeast
cellular response to dna damage stimulus GO:0006974 207 0.771
protein catabolic process GO:0030163 221 0.702
Yeast
macromolecule catabolic process GO:0009057 281 0.646
Yeast
multicellular organismal aging GO:0010259 24 0.611
Worm
proteasome assembly GO:0043248 1 0.508
male gamete generation GO:0048232 285 0.369
microtubule cytoskeleton organization GO:0000226 157 0.286
spermatid differentiation GO:0048515 115 0.194
nucleoside triphosphate metabolic process GO:0009141 230 0.163
oocyte anterior posterior axis specification GO:0007314 2 0.157
determination of adult lifespan GO:0008340 11 0.152
Worm
mitotic cell cycle GO:0000278 195 0.135
positive regulation of dna templated transcription elongation GO:0032786 2 0.134
engulfment of apoptotic cell GO:0043652 3 0.121
spermatid development GO:0007286 108 0.121
oocyte construction GO:0007308 2 0.110
positive regulation of hydrolase activity GO:0051345 148 0.104
mitochondrial transport GO:0006839 36 0.101
microtubule based process GO:0007017 236 0.098
maternal determination of anterior posterior axis embryo GO:0008358 2 0.089
organelle fission GO:0048285 170 0.083
positive regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032436 23 0.078
spermatogenesis GO:0007283 284 0.076
cellular nitrogen compound catabolic process GO:0044270 280 0.075
oocyte axis specification GO:0007309 2 0.073
germ cell development GO:0007281 185 0.071
pole plasm assembly GO:0007315 2 0.069
axonogenesis GO:0007409 274 0.068
establishment of protein localization to organelle GO:0072594 118 0.064
dna metabolic process GO:0006259 303 0.062
regulation of cellular response to stress GO:0080135 159 0.062
meiotic cell cycle GO:0051321 122 0.060
positive regulation of transcription elongation from rna polymerase ii promoter GO:0032968 2 0.057
positive regulation of cellular protein catabolic process GO:1903364 34 0.056
negative regulation of molecular function GO:0044092 258 0.055
ribonucleoside metabolic process GO:0009119 245 0.054
mitochondrion organization GO:0007005 134 0.053
aromatic compound catabolic process GO:0019439 286 0.052
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 40 0.051
spindle organization GO:0007051 28 0.048
organelle assembly GO:0070925 177 0.048
transmembrane transport GO:0055085 412 0.047
nucleotide metabolic process GO:0009117 332 0.046
response to organonitrogen compound GO:0010243 246 0.045
positive regulation of peptidase activity GO:0010952 49 0.044
intracellular mrna localization GO:0008298 4 0.041
guanosine containing compound metabolic process GO:1901068 144 0.040
regulation of stress activated mapk cascade GO:0032872 69 0.040
amine metabolic process GO:0009308 45 0.038
regulation of protein maturation GO:1903317 96 0.038
cellular protein complex assembly GO:0043623 116 0.038
positive regulation of proteolysis GO:0045862 85 0.037
nitrogen compound transport GO:0071705 271 0.035
gonad development GO:0008406 141 0.035
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 31 0.035
positive regulation of cell death GO:0010942 224 0.034
inflammatory response GO:0006954 244 0.034
protein secretion GO:0009306 111 0.033
cellular amino acid metabolic process GO:0006520 103 0.032
regulation of multi organism process GO:0043900 111 0.032
protein targeting GO:0006605 143 0.031
protein import GO:0017038 101 0.031
chromatin modification GO:0016568 187 0.031
dephosphorylation GO:0016311 129 0.030
cytoplasmic transport GO:0016482 234 0.030
response to temperature stimulus GO:0009266 55 0.029
cellular amine metabolic process GO:0044106 44 0.029
endocytosis GO:0006897 168 0.029
negative regulation of immune system process GO:0002683 209 0.029
forebrain development GO:0030900 302 0.028
protein localization to mitochondrion GO:0070585 15 0.028
response to oxidative stress GO:0006979 123 0.028
purine containing compound metabolic process GO:0072521 311 0.028
regulation of cellular amino acid metabolic process GO:0006521 5 0.028
protein refolding GO:0042026 1 0.027
meiotic cell cycle process GO:1903046 77 0.027
carbohydrate homeostasis GO:0033500 128 0.027
mitotic cell cycle process GO:1903047 159 0.027
maintenance of location GO:0051235 89 0.026
alcohol metabolic process GO:0006066 116 0.026
negative regulation of cellular protein metabolic process GO:0032269 247 0.026
positive regulation of cellular amine metabolic process GO:0033240 5 0.025
cell maturation GO:0048469 127 0.025
membrane organization GO:0061024 245 0.025
protein maturation GO:0051604 176 0.024
positive regulation of cell development GO:0010720 237 0.024
regulation of cell cycle GO:0051726 281 0.024
protein localization to membrane GO:0072657 108 0.024
apoptotic signaling pathway GO:0097190 306 0.024
positive regulation of cell cycle GO:0045787 92 0.023
regulation of binding GO:0051098 111 0.023
translation GO:0006412 93 0.023
endomembrane system organization GO:0010256 147 0.023
mitotic nuclear division GO:0007067 48 0.023
oogenesis GO:0048477 56 0.023
camera type eye development GO:0043010 266 0.022
response to peptide GO:1901652 136 0.022
cellular lipid metabolic process GO:0044255 323 0.022
regionalization GO:0003002 337 0.022
heterocycle catabolic process GO:0046700 280 0.022
purine nucleotide catabolic process GO:0006195 211 0.021
stem cell differentiation GO:0048863 268 0.021
nucleoside metabolic process GO:0009116 246 0.021
regulation of inflammatory response GO:0050727 147 0.021
cellular response to oxidative stress GO:0034599 76 0.021
body morphogenesis GO:0010171 45 0.020
rna polymerase ii transcriptional preinitiation complex assembly GO:0051123 3 0.020
protein processing GO:0016485 163 0.020
female gamete generation GO:0007292 74 0.020
intracellular protein transport GO:0006886 204 0.019
posttranscriptional regulation of gene expression GO:0010608 155 0.019
positive regulation of rna polymerase ii transcriptional preinitiation complex assembly GO:0045899 2 0.019
nucleoside phosphate metabolic process GO:0006753 338 0.019
regulation of cellular component biogenesis GO:0044087 181 0.019
mrna processing GO:0006397 63 0.019
regulation of proteasomal protein catabolic process GO:0061136 46 0.019
mapk cascade GO:0000165 281 0.019
regulation of histone h3 k4 methylation GO:0051569 12 0.019
cell division GO:0051301 120 0.018
developmental maturation GO:0021700 193 0.018
negative regulation of cellular component organization GO:0051129 194 0.018
positive regulation of protein modification process GO:0031401 299 0.018
positive regulation of kinase activity GO:0033674 155 0.018
regulation of cellular amine metabolic process GO:0033238 20 0.018
telencephalon development GO:0021537 186 0.018
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 62 0.018
synaptic transmission GO:0007268 329 0.018
stem cell development GO:0048864 219 0.018
protein localization to organelle GO:0033365 185 0.018
regulation of translation GO:0006417 71 0.018
nucleotide catabolic process GO:0009166 217 0.018
regulation of peptidase activity GO:0052547 96 0.017
positive regulation of mapk cascade GO:0043410 170 0.017
double strand break repair GO:0006302 48 0.017
fertilization GO:0009566 127 0.017
regulation of kinase activity GO:0043549 249 0.017
positive regulation of cellular catabolic process GO:0031331 148 0.017
cellular response to lipid GO:0071396 145 0.017
stress activated mapk cascade GO:0051403 80 0.017
regulation of cellular catabolic process GO:0031329 242 0.017
dna repair GO:0006281 107 0.016
lymphocyte proliferation GO:0046651 164 0.016
establishment or maintenance of cell polarity GO:0007163 86 0.016
leukocyte proliferation GO:0070661 172 0.016
regulation of transferase activity GO:0051338 263 0.016
dna templated transcriptional preinitiation complex assembly GO:0070897 4 0.016
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.016
response to lipopolysaccharide GO:0032496 128 0.016
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.016
glucose homeostasis GO:0042593 128 0.016
mitotic spindle organization GO:0007052 10 0.015
negative regulation of protein processing GO:0010955 79 0.015
establishment or maintenance of microtubule cytoskeleton polarity GO:0030951 1 0.015
protein homotrimerization GO:0070207 4 0.015
regulation of cellular ketone metabolic process GO:0010565 66 0.015
lipid localization GO:0010876 126 0.015
nuclear import GO:0051170 95 0.015
positive regulation of apoptotic process GO:0043065 217 0.015
regulation of protein kinase activity GO:0045859 232 0.015
cellular ketone metabolic process GO:0042180 84 0.015
regulation of metal ion transport GO:0010959 106 0.014
positive regulation of growth GO:0045927 104 0.014
lipid biosynthetic process GO:0008610 179 0.014
nucleobase containing compound transport GO:0015931 27 0.014
ribonucleotide catabolic process GO:0009261 208 0.014
extracellular structure organization GO:0043062 148 0.014
regulation of reproductive process GO:2000241 66 0.014
development of primary sexual characteristics GO:0045137 143 0.014
t cell activation GO:0042110 289 0.014
dendrite development GO:0016358 115 0.014
double strand break repair via nonhomologous end joining GO:0006303 10 0.014
purine ribonucleoside metabolic process GO:0046128 241 0.014
compound eye development GO:0048749 1 0.014
protein modification by small protein conjugation or removal GO:0070647 207 0.014
inorganic cation transmembrane transport GO:0098662 207 0.014
negative regulation of response to wounding GO:1903035 77 0.014
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.014
single organism nuclear import GO:1902593 95 0.014
response to alcohol GO:0097305 48 0.013
non recombinational repair GO:0000726 10 0.013
nuclear division GO:0000280 158 0.013
response to organic cyclic compound GO:0014070 198 0.013
negative regulation of protein metabolic process GO:0051248 282 0.013
epithelial to mesenchymal transition GO:0001837 47 0.013
spindle assembly involved in mitosis GO:0090307 4 0.013
guanosine containing compound catabolic process GO:1901069 144 0.013
digestive tract morphogenesis GO:0048546 147 0.013
ribonucleoside triphosphate metabolic process GO:0009199 220 0.013
positive regulation of protein catabolic process GO:0045732 60 0.013
protein deubiquitination GO:0016579 19 0.013
regulation of endopeptidase activity GO:0052548 89 0.013
mirna catabolic process GO:0010587 2 0.013
zymogen activation GO:0031638 41 0.012
regulation of proteolysis GO:0030162 164 0.012
nucleoside phosphate catabolic process GO:1901292 222 0.012
regulation of lymphocyte activation GO:0051249 240 0.012
sperm individualization GO:0007291 1 0.012
single fertilization GO:0007338 82 0.012
regulation of membrane potential GO:0042391 192 0.012
oocyte differentiation GO:0009994 35 0.012
glycerolipid biosynthetic process GO:0045017 50 0.012
cation transport GO:0006812 399 0.012
molting cycle GO:0042303 90 0.012
Worm
regulation of jnk cascade GO:0046328 62 0.012
segmentation GO:0035282 93 0.012
purine ribonucleotide metabolic process GO:0009150 290 0.012
organic hydroxy compound metabolic process GO:1901615 203 0.012
protein localization to chromatin GO:0071168 3 0.011
adult locomotory behavior GO:0008344 91 0.011
response to peptide hormone GO:0043434 127 0.011
nucleus organization GO:0006997 45 0.011
regulation of rna polymerase ii transcriptional preinitiation complex assembly GO:0045898 2 0.011
multi multicellular organism process GO:0044706 109 0.011
morphogenesis of embryonic epithelium GO:0016331 159 0.011
regulation of mapk cascade GO:0043408 248 0.011
organic cyclic compound catabolic process GO:1901361 295 0.011
nuclear transport GO:0051169 139 0.011
organophosphate catabolic process GO:0046434 232 0.011
rna processing GO:0006396 105 0.011
er associated ubiquitin dependent protein catabolic process GO:0030433 10 0.011
exocytosis GO:0006887 121 0.011
regulation of ion transmembrane transporter activity GO:0032412 54 0.011
regulation of exit from mitosis GO:0007096 1 0.011
regulation of hydrolase activity GO:0051336 246 0.011
stem cell maintenance GO:0019827 130 0.011
protein autophosphorylation GO:0046777 61 0.011
ribosomal large subunit assembly GO:0000027 2 0.011
positive regulation of transcription initiation from rna polymerase ii promoter GO:0060261 5 0.011
sensory perception GO:0007600 245 0.011
maturation of lsu rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna GO:0000463 1 0.011
carbohydrate derivative catabolic process GO:1901136 231 0.011
establishment or maintenance of cytoskeleton polarity GO:0030952 2 0.010
regulation of transmembrane transport GO:0034762 128 0.010
organelle disassembly GO:1903008 2 0.010
cellular chemical homeostasis GO:0055082 215 0.010
mitotic cytokinesis GO:0000281 4 0.010
peptidyl amino acid modification GO:0018193 336 0.010

Psma1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
muscular disease DOID:0080000 0 0.044
disease of anatomical entity DOID:7 0 0.044
musculoskeletal system disease DOID:17 0 0.044
myopathy DOID:423 0 0.024
muscle tissue disease DOID:66 0 0.024
disease of metabolism DOID:0014667 0 0.020
central nervous system disease DOID:331 0 0.014
neurodegenerative disease DOID:1289 0 0.014
nervous system disease DOID:863 0 0.014
inherited metabolic disorder DOID:655 0 0.011