Mus musculus

64 known processes

Psmc5

protease (prosome, macropain) 26S subunit, ATPase 5

(Aliases: mSUG1)

Psmc5 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular protein catabolic process GO:0044257 155 0.818
Human Yeast Worm
cellular macromolecule catabolic process GO:0044265 206 0.730
Human Yeast Worm
protein modification by small protein conjugation GO:0032446 187 0.597
protein modification by small protein conjugation or removal GO:0070647 207 0.537
macromolecule catabolic process GO:0009057 281 0.528
Human Yeast Worm
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.517
Human Yeast Worm
protein catabolic process GO:0030163 221 0.505
Human Yeast Worm
proteasomal protein catabolic process GO:0010498 98 0.445
Human Yeast Worm
regulation of rna polymerase ii transcriptional preinitiation complex assembly GO:0045898 2 0.384
Yeast
cellular response to dna damage stimulus GO:0006974 207 0.362
Yeast Fly
purine ribonucleotide metabolic process GO:0009150 290 0.313
Rat
protein folding GO:0006457 28 0.297
microtubule cytoskeleton organization involved in mitosis GO:1902850 4 0.281
spindle assembly involved in mitosis GO:0090307 4 0.281
protein ubiquitination GO:0016567 171 0.275
oocyte construction GO:0007308 2 0.272
proteasome assembly GO:0043248 1 0.268
Yeast
purine ribonucleoside metabolic process GO:0046128 241 0.244
Rat
gene silencing by rna GO:0031047 19 0.237
oocyte axis specification GO:0007309 2 0.222
inclusion body assembly GO:0070841 3 0.222
Rat
modification dependent protein catabolic process GO:0019941 133 0.186
Human Yeast Worm
protein refolding GO:0042026 1 0.174
ribonucleotide catabolic process GO:0009261 208 0.146
Rat
blastocyst development GO:0001824 80 0.145
cellular protein complex assembly GO:0043623 116 0.134
Yeast
positive regulation of transcription initiation from rna polymerase ii promoter GO:0060261 5 0.126
Yeast
fertilization GO:0009566 127 0.123
striated muscle myosin thick filament assembly GO:0071688 1 0.120
modification dependent macromolecule catabolic process GO:0043632 133 0.118
Human Yeast Worm
regulation of cell cycle phase transition GO:1901987 77 0.116
regulation of protein catabolic process GO:0042176 108 0.116
purine nucleoside triphosphate metabolic process GO:0009144 226 0.113
Rat
positive regulation of dna templated transcription initiation GO:2000144 5 0.112
Yeast
ribonucleotide metabolic process GO:0009259 291 0.110
Rat
signal transduction by p53 class mediator GO:0072331 51 0.109
atp catabolic process GO:0006200 55 0.109
Rat
organic cyclic compound catabolic process GO:1901361 295 0.096
Yeast Rat
dephosphorylation GO:0016311 129 0.095
mitotic cell cycle process GO:1903047 159 0.089
Worm
spermatogenesis GO:0007283 284 0.086
regulation of proteolysis GO:0030162 164 0.084
rna interference GO:0016246 2 0.083
ubiquitin dependent protein catabolic process GO:0006511 129 0.081
Human Yeast Worm
sperm egg recognition GO:0035036 37 0.081
spindle organization GO:0007051 28 0.080
oocyte differentiation GO:0009994 35 0.079
regulation of protein kinase activity GO:0045859 232 0.079
protein dna complex subunit organization GO:0071824 28 0.077
Yeast
ribonucleoside triphosphate metabolic process GO:0009199 220 0.077
Rat
nucleotide catabolic process GO:0009166 217 0.068
Rat
dna metabolic process GO:0006259 303 0.066
Yeast
aromatic compound catabolic process GO:0019439 286 0.066
Yeast Rat
organelle assembly GO:0070925 177 0.065
regulation of protein modification by small protein conjugation or removal GO:1903320 57 0.063
double strand break repair GO:0006302 48 0.062
regulation of cellular catabolic process GO:0031329 242 0.059
positive regulation of hydrolase activity GO:0051345 148 0.058
purine containing compound metabolic process GO:0072521 311 0.057
Rat
microtubule cytoskeleton organization GO:0000226 157 0.056
microtubule based process GO:0007017 236 0.056
nuclear transport GO:0051169 139 0.055
regulation of hydrolase activity GO:0051336 246 0.054
purine nucleotide metabolic process GO:0006163 302 0.053
Rat
small gtpase mediated signal transduction GO:0007264 97 0.053
oocyte development GO:0048599 33 0.053
organophosphate catabolic process GO:0046434 232 0.053
Rat
purine ribonucleoside monophosphate catabolic process GO:0009169 57 0.052
Rat
chromosome segregation GO:0007059 48 0.051
Worm
positive regulation of cellular component biogenesis GO:0044089 94 0.051
Yeast Rat
aggresome assembly GO:0070842 2 0.051
inner cell mass cell proliferation GO:0001833 15 0.050
nucleoside catabolic process GO:0009164 206 0.048
Rat
single fertilization GO:0007338 82 0.048
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.047
Human Yeast Worm
purine containing compound catabolic process GO:0072523 213 0.047
Rat
oogenesis GO:0048477 56 0.047
nucleoside monophosphate catabolic process GO:0009125 59 0.046
Rat
regulation of protein ubiquitination GO:0031396 52 0.046
posttranscriptional gene silencing GO:0016441 10 0.045
positive regulation of protein phosphorylation GO:0001934 242 0.045
regulation of cellular component biogenesis GO:0044087 181 0.045
Yeast Rat
cellular nitrogen compound catabolic process GO:0044270 280 0.044
Yeast Rat
regulation of cellular protein catabolic process GO:1903362 61 0.043
regulation of cell division GO:0051302 76 0.042
Worm
heterocycle catabolic process GO:0046700 280 0.042
Yeast Rat
glycosyl compound catabolic process GO:1901658 206 0.041
Rat
negative regulation of protein metabolic process GO:0051248 282 0.041
regulation of transferase activity GO:0051338 263 0.041
development of primary sexual characteristics GO:0045137 143 0.041
Worm
cellular ketone metabolic process GO:0042180 84 0.040
posttranscriptional regulation of gene expression GO:0010608 155 0.039
purine nucleoside catabolic process GO:0006152 205 0.039
Rat
positive regulation of cellular catabolic process GO:0031331 148 0.039
regulation of protein localization GO:0032880 231 0.039
gonad development GO:0008406 141 0.038
Worm
positive regulation of transferase activity GO:0051347 167 0.038
purine nucleoside metabolic process GO:0042278 241 0.038
Rat
glycosyl compound metabolic process GO:1901657 246 0.038
Rat
ribonucleoside metabolic process GO:0009119 245 0.038
Rat
retrograde protein transport er to cytosol GO:0030970 1 0.038
regulation of kinase activity GO:0043549 249 0.037
oocyte anterior posterior axis specification GO:0007314 2 0.037
amine metabolic process GO:0009308 45 0.037
mitotic cell cycle GO:0000278 195 0.036
Worm
developmental maturation GO:0021700 193 0.035
negative regulation of neuron death GO:1901215 98 0.035
response to organic cyclic compound GO:0014070 198 0.035
binding of sperm to zona pellucida GO:0007339 34 0.035
nucleoside phosphate metabolic process GO:0006753 338 0.034
Rat
endocytosis GO:0006897 168 0.034
carbohydrate derivative catabolic process GO:1901136 231 0.034
Rat
protein localization to nucleus GO:0034504 121 0.034
ras protein signal transduction GO:0007265 77 0.033
negative regulation of phosphorus metabolic process GO:0010563 184 0.033
translation GO:0006412 93 0.033
dna templated transcriptional preinitiation complex assembly GO:0070897 4 0.033
Yeast
organonitrogen compound catabolic process GO:1901565 264 0.032
Rat
ribonucleoside monophosphate catabolic process GO:0009158 57 0.032
Rat
nucleotide metabolic process GO:0009117 332 0.031
Rat
molting cycle GO:0042303 90 0.031
negative regulation of intracellular signal transduction GO:1902532 167 0.031
intracellular mrna localization GO:0008298 4 0.031
multicellular organismal aging GO:0010259 24 0.031
Worm
transmembrane transport GO:0055085 412 0.031
regulation of cell cycle process GO:0010564 160 0.031
Worm
positive regulation of cell death GO:0010942 224 0.031
mapk cascade GO:0000165 281 0.031
proteasomal ubiquitin independent protein catabolic process GO:0010499 1 0.031
positive regulation of protein catabolic process GO:0045732 60 0.030
purine nucleoside monophosphate catabolic process GO:0009128 58 0.030
Rat
organelle fusion GO:0048284 28 0.030
positive regulation of peptidase activity GO:0010952 49 0.029
ribonucleoside triphosphate catabolic process GO:0009203 199 0.029
Rat
male gamete generation GO:0048232 285 0.029
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.029
Rat
mitotic spindle organization GO:0007052 10 0.029
negative regulation of cellular protein metabolic process GO:0032269 247 0.029
negative regulation of cell development GO:0010721 169 0.029
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 56 0.029
regulation of intracellular transport GO:0032386 159 0.029
mitotic nuclear division GO:0007067 48 0.028
Worm
nucleoside triphosphate catabolic process GO:0009143 205 0.028
Rat
positive regulation of protein modification process GO:0031401 299 0.028
establishment of organelle localization GO:0051656 122 0.027
regulation of cell cycle GO:0051726 281 0.027
Worm
cation transmembrane transport GO:0098655 266 0.027
peptidyl amino acid modification GO:0018193 336 0.027
regulation of organelle organization GO:0033043 289 0.026
Worm
positive regulation of protein complex assembly GO:0031334 45 0.026
Yeast
cellular amino acid metabolic process GO:0006520 103 0.026
negative regulation of cellular component organization GO:0051129 194 0.026
divalent metal ion transport GO:0070838 172 0.026
purine nucleoside triphosphate catabolic process GO:0009146 203 0.026
Rat
trna aminoacylation for protein translation GO:0006418 1 0.025
positive regulation of mapk cascade GO:0043410 170 0.025
protein polymerization GO:0051258 57 0.025
regulation of protein complex assembly GO:0043254 83 0.025
Yeast
cell maturation GO:0048469 127 0.025
nucleoside phosphate catabolic process GO:1901292 222 0.025
Rat
forebrain development GO:0030900 302 0.025
organelle disassembly GO:1903008 2 0.025
methylation GO:0032259 134 0.024
regulation of ras protein signal transduction GO:0046578 114 0.024
negative regulation of cell cycle phase transition GO:1901988 48 0.024
negative regulation of ligase activity GO:0051352 3 0.024
apoptotic signaling pathway GO:0097190 306 0.023
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.023
Rat
cell adhesion GO:0007155 329 0.023
regulation of cellular ketone metabolic process GO:0010565 66 0.023
stem cell differentiation GO:0048863 268 0.023
protein import into nucleus GO:0006606 95 0.023
regionalization GO:0003002 337 0.023
inorganic ion transmembrane transport GO:0098660 234 0.023
photoreceptor cell development GO:0042461 40 0.022
response to organonitrogen compound GO:0010243 246 0.022
positive regulation of nucleoside metabolic process GO:0045979 91 0.022
organelle localization GO:0051640 179 0.022
wnt signaling pathway GO:0016055 188 0.022
cellular response to cadmium ion GO:0071276 3 0.022
nucleic acid transport GO:0050657 18 0.021
positive regulation of protein kinase activity GO:0045860 144 0.021
nitrogen compound transport GO:0071705 271 0.021
rhythmic process GO:0048511 174 0.021
purine nucleotide catabolic process GO:0006195 211 0.021
Rat
positive regulation of endopeptidase activity GO:0010950 43 0.021
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 40 0.021
muscle cell differentiation GO:0042692 261 0.021
fatty acid metabolic process GO:0006631 121 0.021
purine ribonucleotide catabolic process GO:0009154 208 0.021
Rat
nucleoside triphosphate metabolic process GO:0009141 230 0.021
Rat
positive regulation of nervous system development GO:0051962 221 0.021
regulation of translation GO:0006417 71 0.021
regulation of intrinsic apoptotic signaling pathway GO:2001242 61 0.021
regulation of proteasomal protein catabolic process GO:0061136 46 0.021
purine ribonucleoside catabolic process GO:0046130 205 0.020
Rat
protein localization to organelle GO:0033365 185 0.020
erk1 and erk2 cascade GO:0070371 77 0.020
gene silencing GO:0016458 38 0.020
organic hydroxy compound metabolic process GO:1901615 203 0.020
leukocyte proliferation GO:0070661 172 0.020
negative regulation of dna damage response signal transduction by p53 class mediator GO:0043518 5 0.019
trna metabolic process GO:0006399 11 0.019
dna damage response signal transduction by p53 class mediator GO:0030330 19 0.019
negative regulation of cell cycle process GO:0010948 69 0.019
microtubule polymerization GO:0046785 12 0.019
membrane fusion GO:0061025 38 0.019
cellular amine metabolic process GO:0044106 44 0.019
negative regulation of cell proliferation GO:0008285 296 0.019
nucleobase containing compound transport GO:0015931 27 0.019
female gamete generation GO:0007292 74 0.019
translesion synthesis GO:0019985 1 0.019
regulation of peptidase activity GO:0052547 96 0.019
regulation of cellular amine metabolic process GO:0033238 20 0.019
cell type specific apoptotic process GO:0097285 268 0.019
protein deubiquitination GO:0016579 19 0.018
cell recognition GO:0008037 83 0.018
cytoplasmic transport GO:0016482 234 0.018
toxin transport GO:1901998 38 0.018
respiratory system development GO:0060541 190 0.018
atp metabolic process GO:0046034 75 0.018
Rat
positive regulation of proteolysis GO:0045862 85 0.018
nuclear import GO:0051170 95 0.018
positive regulation of cell development GO:0010720 237 0.018
t cell proliferation GO:0042098 120 0.017
regulation of cytoplasmic transport GO:1903649 112 0.017
receptor mediated endocytosis GO:0006898 51 0.017
negative regulation of phosphate metabolic process GO:0045936 184 0.017
negative regulation of molecular function GO:0044092 258 0.017
Yeast
single organism cell adhesion GO:0098602 156 0.017
organelle membrane fusion GO:0090174 1 0.017
establishment or maintenance of cytoskeleton polarity GO:0030952 2 0.016
axonogenesis GO:0007409 274 0.016
positive regulation of kinase activity GO:0033674 155 0.016
spermatid differentiation GO:0048515 115 0.016
negative regulation of protein modification process GO:0031400 163 0.016
organelle fission GO:0048285 170 0.016
Worm
nucleobase containing small molecule metabolic process GO:0055086 352 0.016
Rat
regulation of transcription initiation from rna polymerase ii promoter GO:0060260 6 0.016
Yeast
homeostasis of number of cells GO:0048872 210 0.015
cation transport GO:0006812 399 0.015
single organism nuclear import GO:1902593 95 0.015
regulation of cell motility GO:2000145 236 0.015
negative regulation of neuron apoptotic process GO:0043524 92 0.015
rna splicing via transesterification reactions GO:0000375 43 0.015
trna wobble uridine modification GO:0002098 2 0.015
regulation of phosphatidylcholine biosynthetic process GO:2001245 2 0.015
negative regulation of cell cycle GO:0045786 123 0.015
photoreceptor cell differentiation GO:0046530 52 0.015
maternal determination of anterior posterior axis embryo GO:0008358 2 0.015
positive regulation of purine nucleotide catabolic process GO:0033123 88 0.015
mrna splicing via spliceosome GO:0000398 43 0.015
transmission of nerve impulse GO:0019226 76 0.015
positive regulation of rna splicing GO:0033120 12 0.014
regulation of endopeptidase activity GO:0052548 89 0.014
locomotory behavior GO:0007626 195 0.014
response to peptide hormone GO:0043434 127 0.014
action potential GO:0001508 78 0.014
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.014
positive regulation of astrocyte differentiation GO:0048711 8 0.014
regulation of cellular response to stress GO:0080135 159 0.014
regulation of protein transport GO:0051223 163 0.014
intrinsic apoptotic signaling pathway GO:0097193 132 0.014
cell activation involved in immune response GO:0002263 126 0.014
regulation of erk1 and erk2 cascade GO:0070372 71 0.014
cell division GO:0051301 120 0.013
Worm
divalent inorganic cation transport GO:0072511 178 0.013
rna polymerase ii transcriptional preinitiation complex assembly GO:0051123 3 0.013
Yeast
trna aminoacylation GO:0043039 1 0.013
negative regulation of microtubule polymerization GO:0031115 2 0.013
negative regulation of protein modification by small protein conjugation or removal GO:1903321 20 0.013
regulation of cysteine type endopeptidase activity GO:2000116 65 0.013
single organismal cell cell adhesion GO:0016337 131 0.013
ribonucleoside monophosphate metabolic process GO:0009161 80 0.013
Rat
ribonucleoprotein complex subunit organization GO:0071826 28 0.013
multicellular organismal signaling GO:0035637 91 0.013
myosin filament organization GO:0031033 3 0.013
regulation of establishment of protein localization GO:0070201 181 0.013
establishment or maintenance of microtubule cytoskeleton polarity GO:0030951 1 0.013
positive regulation of mrna splicing via spliceosome GO:0048026 11 0.013
histone modification GO:0016570 159 0.013
neuronal action potential GO:0019228 54 0.012
epithelial tube morphogenesis GO:0060562 303 0.012
ribose phosphate metabolic process GO:0019693 291 0.012
Rat
positive regulation of apoptotic process GO:0043065 217 0.012
meiotic cell cycle GO:0051321 122 0.012
response to temperature stimulus GO:0009266 55 0.012
transcription initiation from rna polymerase ii promoter GO:0006367 8 0.012
Yeast
inorganic cation transmembrane transport GO:0098662 207 0.012
actin cytoskeleton organization GO:0030036 220 0.012
regulation of neuron apoptotic process GO:0043523 122 0.012
striated muscle tissue development GO:0014706 293 0.012
purine nucleoside monophosphate metabolic process GO:0009126 81 0.012
Rat
negative regulation of cell motility GO:2000146 61 0.012
purine ribonucleotide biosynthetic process GO:0009152 59 0.012
dna recombination GO:0006310 92 0.012
nucleocytoplasmic transport GO:0006913 139 0.012
telencephalon development GO:0021537 186 0.012
microtubule organizing center organization GO:0031023 28 0.011
lipid biosynthetic process GO:0008610 179 0.011
pallium development GO:0021543 120 0.011
regulation of cellular amino acid metabolic process GO:0006521 5 0.011
negative regulation of apoptotic signaling pathway GO:2001234 104 0.011
ion transmembrane transport GO:0034220 361 0.011
calcium ion transport GO:0006816 159 0.011
brain segmentation GO:0035284 3 0.011
regulation of glial cell differentiation GO:0045685 41 0.011
regulation of homeostatic process GO:0032844 182 0.011
regulation of epithelial cell proliferation GO:0050678 141 0.011
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.011
response to acid chemical GO:0001101 111 0.011
positive regulation of nucleotide catabolic process GO:0030813 88 0.011
response to radiation GO:0009314 165 0.011
pole plasm assembly GO:0007315 2 0.011
regulation of neuron differentiation GO:0045664 281 0.011
signal transduction in response to dna damage GO:0042770 21 0.011
protein maturation GO:0051604 176 0.011
cellular component assembly involved in morphogenesis GO:0010927 139 0.011
cellular carbohydrate metabolic process GO:0044262 119 0.011
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.011
regulation of protein maturation GO:1903317 96 0.011
regulation of mrna metabolic process GO:1903311 43 0.011
metaphase plate congression GO:0051310 2 0.011
mitochondrion organization GO:0007005 134 0.011
digestive system development GO:0055123 200 0.011
regulation of ion transmembrane transport GO:0034765 119 0.011
small molecule biosynthetic process GO:0044283 132 0.011
protein oligomerization GO:0051259 67 0.011
regulation of purine nucleotide catabolic process GO:0033121 122 0.010
positive regulation of programmed cell death GO:0043068 218 0.010
establishment of rna localization GO:0051236 18 0.010
regulation of response to dna damage stimulus GO:2001020 34 0.010
regulation of inflammatory response GO:0050727 147 0.010
regulation of mitotic cell cycle phase transition GO:1901990 73 0.010
chromatin modification GO:0016568 187 0.010
Yeast
nucleoside metabolic process GO:0009116 246 0.010
Rat
regulation of ion transport GO:0043269 215 0.010
rna processing GO:0006396 105 0.010
glycoprotein metabolic process GO:0009100 116 0.010
establishment or maintenance of cell polarity GO:0007163 86 0.010
germ cell development GO:0007281 185 0.010
nuclear division GO:0000280 158 0.010
Worm
cellular homeostasis GO:0019725 240 0.010
regulation of wnt signaling pathway GO:0030111 123 0.010

Psmc5 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
central nervous system disease DOID:331 0 0.084
disease of anatomical entity DOID:7 0 0.084
nervous system disease DOID:863 0 0.084
neuropathy DOID:870 0 0.028
neuromuscular disease DOID:440 0 0.021
charcot marie tooth disease DOID:10595 0 0.021
neurodegenerative disease DOID:1289 0 0.021