Mus musculus

107 known processes

Psme4

proteasome (prosome, macropain) activator subunit 4

(Aliases: TEMO,AU041366,KIAA0077,AA409398,mKIAA0077)

Psme4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.603
macromolecule catabolic process GO:0009057 281 0.537
modification dependent protein catabolic process GO:0019941 133 0.419
modification dependent macromolecule catabolic process GO:0043632 133 0.393
cellular macromolecule catabolic process GO:0044265 206 0.369
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.342
regulation of cellular catabolic process GO:0031329 242 0.277
cellular protein catabolic process GO:0044257 155 0.270
proteasomal protein catabolic process GO:0010498 98 0.207
positive regulation of cellular catabolic process GO:0031331 148 0.180
regulation of translation GO:0006417 71 0.177
posttranscriptional regulation of gene expression GO:0010608 155 0.154
mitotic cell cycle GO:0000278 195 0.153
translation GO:0006412 93 0.145
ubiquitin dependent protein catabolic process GO:0006511 129 0.138
protein catabolic process GO:0030163 221 0.109
purine containing compound metabolic process GO:0072521 311 0.103
protein modification by small protein removal GO:0070646 21 0.101
carbohydrate derivative catabolic process GO:1901136 231 0.090
ribose phosphate metabolic process GO:0019693 291 0.087
nucleoside phosphate metabolic process GO:0006753 338 0.086
nucleotide catabolic process GO:0009166 217 0.084
gtp metabolic process GO:0046039 144 0.081
nucleoside triphosphate catabolic process GO:0009143 205 0.079
protein modification by small protein conjugation GO:0032446 187 0.077
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 56 0.076
ras protein signal transduction GO:0007265 77 0.076
organic cyclic compound catabolic process GO:1901361 295 0.075
protein modification by small protein conjugation or removal GO:0070647 207 0.073
purine ribonucleotide metabolic process GO:0009150 290 0.073
lipid localization GO:0010876 126 0.071
guanosine containing compound metabolic process GO:1901068 144 0.070
purine ribonucleoside catabolic process GO:0046130 205 0.066
purine nucleoside triphosphate metabolic process GO:0009144 226 0.065
membrane organization GO:0061024 245 0.063
small gtpase mediated signal transduction GO:0007264 97 0.061
endomembrane system organization GO:0010256 147 0.061
purine nucleotide catabolic process GO:0006195 211 0.061
purine nucleoside metabolic process GO:0042278 241 0.060
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 31 0.060
nucleotide metabolic process GO:0009117 332 0.060
regulation of nucleoside metabolic process GO:0009118 130 0.055
nucleoside triphosphate metabolic process GO:0009141 230 0.055
purine nucleoside catabolic process GO:0006152 205 0.052
negative regulation of cellular protein metabolic process GO:0032269 247 0.051
cellular nitrogen compound catabolic process GO:0044270 280 0.050
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.049
regulation of cell cycle GO:0051726 281 0.049
positive regulation of gtpase activity GO:0043547 85 0.049
nucleoside metabolic process GO:0009116 246 0.049
tissue migration GO:0090130 68 0.047
organophosphate catabolic process GO:0046434 232 0.046
purine ribonucleotide catabolic process GO:0009154 208 0.046
regulation of hydrolase activity GO:0051336 246 0.046
purine nucleotide metabolic process GO:0006163 302 0.045
regulation of organelle organization GO:0033043 289 0.044
glycosyl compound metabolic process GO:1901657 246 0.044
purine nucleoside triphosphate catabolic process GO:0009146 203 0.043
regulation of nucleotide metabolic process GO:0006140 169 0.043
maintenance of location GO:0051235 89 0.042
intracellular steroid hormone receptor signaling pathway GO:0030518 29 0.042
organonitrogen compound catabolic process GO:1901565 264 0.041
regulation of ras gtpase activity GO:0032318 88 0.041
ribonucleotide catabolic process GO:0009261 208 0.041
purine ribonucleoside metabolic process GO:0046128 241 0.040
nucleobase containing small molecule metabolic process GO:0055086 352 0.040
aromatic compound catabolic process GO:0019439 286 0.040
positive regulation of purine nucleotide catabolic process GO:0033123 88 0.039
ribonucleoside triphosphate catabolic process GO:0009203 199 0.039
regulation of gtp catabolic process GO:0033124 113 0.039
cellular homeostasis GO:0019725 240 0.038
ribonucleotide metabolic process GO:0009259 291 0.037
actin cytoskeleton organization GO:0030036 220 0.037
intracellular protein transport GO:0006886 204 0.037
regulation of proteasomal protein catabolic process GO:0061136 46 0.037
cellular amine metabolic process GO:0044106 44 0.036
heterocycle catabolic process GO:0046700 280 0.035
ribonucleoside metabolic process GO:0009119 245 0.035
er associated ubiquitin dependent protein catabolic process GO:0030433 10 0.035
ribonucleoside catabolic process GO:0042454 206 0.035
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.035
purine containing compound catabolic process GO:0072523 213 0.034
regulation of nucleotide catabolic process GO:0030811 122 0.034
rho protein signal transduction GO:0007266 32 0.034
negative regulation of protein metabolic process GO:0051248 282 0.034
axonogenesis GO:0007409 274 0.033
mitochondrion organization GO:0007005 134 0.032
regulation of anatomical structure size GO:0090066 178 0.032
cellular amino acid metabolic process GO:0006520 103 0.031
protein oligomerization GO:0051259 67 0.031
adult behavior GO:0030534 135 0.030
digestive tract morphogenesis GO:0048546 147 0.030
multicellular organismal homeostasis GO:0048871 164 0.030
multicellular organismal macromolecule catabolic process GO:0044266 1 0.030
regulation of ras protein signal transduction GO:0046578 114 0.030
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.029
negative regulation of intracellular signal transduction GO:1902532 167 0.029
nitrogen compound transport GO:0071705 271 0.029
lateral inhibition GO:0046331 1 0.029
cellular response to dna damage stimulus GO:0006974 207 0.028
gtp catabolic process GO:0006184 143 0.028
regulation of mitotic cell cycle GO:0007346 126 0.027
positive regulation of nucleotide catabolic process GO:0030813 88 0.027
tube closure GO:0060606 91 0.027
spermatogenesis GO:0007283 284 0.027
protein processing GO:0016485 163 0.027
protein deubiquitination GO:0016579 19 0.027
regulation of purine nucleotide metabolic process GO:1900542 169 0.026
positive regulation of cellular component biogenesis GO:0044089 94 0.026
negative regulation of apoptotic signaling pathway GO:2001234 104 0.026
male gamete generation GO:0048232 285 0.026
protein localization to organelle GO:0033365 185 0.025
regulation of protein catabolic process GO:0042176 108 0.025
positive regulation of cellular protein catabolic process GO:1903364 34 0.025
amine metabolic process GO:0009308 45 0.025
cytoplasmic transport GO:0016482 234 0.025
ribonucleoside triphosphate metabolic process GO:0009199 220 0.025
ion transmembrane transport GO:0034220 361 0.025
protein polyubiquitination GO:0000209 33 0.025
cellular protein complex assembly GO:0043623 116 0.024
neural tube development GO:0021915 160 0.024
cell type specific apoptotic process GO:0097285 268 0.024
engulfment of apoptotic cell GO:0043652 3 0.024
transmembrane transport GO:0055085 412 0.023
regulation of cell cycle process GO:0010564 160 0.023
nucleoside phosphate catabolic process GO:1901292 222 0.023
dna metabolic process GO:0006259 303 0.023
plasma membrane organization GO:0007009 90 0.023
neural tube closure GO:0001843 90 0.023
spermatid differentiation GO:0048515 115 0.023
neural tube formation GO:0001841 108 0.023
regulation of cell motility GO:2000145 236 0.023
positive regulation of nucleoside metabolic process GO:0045979 91 0.023
action potential GO:0001508 78 0.022
neuronal action potential GO:0019228 54 0.022
urogenital system development GO:0001655 261 0.022
sensory organ morphogenesis GO:0090596 242 0.022
transmission of nerve impulse GO:0019226 76 0.022
forebrain development GO:0030900 302 0.021
negative regulation of cellular component organization GO:0051129 194 0.021
nucleoside catabolic process GO:0009164 206 0.021
regulation of mitotic cell cycle phase transition GO:1901990 73 0.021
meiosis i GO:0007127 60 0.021
homeostasis of number of cells GO:0048872 210 0.021
multicellular organismal protein metabolic process GO:0044268 2 0.021
cell substrate adhesion GO:0031589 130 0.021
positive regulation of protein catabolic process GO:0045732 60 0.021
regulation of purine nucleotide catabolic process GO:0033121 122 0.021
negative regulation of cell cycle GO:0045786 123 0.021
response to transforming growth factor beta GO:0071559 88 0.021
ribonucleoside monophosphate metabolic process GO:0009161 80 0.020
positive regulation of nucleotide metabolic process GO:0045981 114 0.020
regulation of transmembrane transport GO:0034762 128 0.020
positive regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032436 23 0.020
regulation of cell migration GO:0030334 219 0.020
cytoskeleton dependent intracellular transport GO:0030705 50 0.020
cellular ion homeostasis GO:0006873 165 0.020
multicellular organismal aging GO:0010259 24 0.020
response to growth factor GO:0070848 198 0.020
epithelial cell migration GO:0010631 63 0.020
negative regulation of neuron apoptotic process GO:0043524 92 0.020
regulation of protein maturation GO:1903317 96 0.020
digestive tract development GO:0048565 190 0.020
regulation of proteolysis GO:0030162 164 0.019
cellular lipid metabolic process GO:0044255 323 0.019
negative regulation of protein modification process GO:0031400 163 0.019
striated muscle myosin thick filament assembly GO:0071688 1 0.019
cellular response to organonitrogen compound GO:0071417 145 0.019
regulation of membrane potential GO:0042391 192 0.019
protein ubiquitination GO:0016567 171 0.019
guanosine containing compound catabolic process GO:1901069 144 0.019
protein maturation GO:0051604 176 0.018
positive regulation of gtp catabolic process GO:0033126 85 0.018
regulation of cell activation GO:0050865 289 0.018
morphogenesis of embryonic epithelium GO:0016331 159 0.018
anatomical structure homeostasis GO:0060249 145 0.018
positive regulation of cellular amine metabolic process GO:0033240 5 0.018
jnk cascade GO:0007254 72 0.018
regulation of cellular ketone metabolic process GO:0010565 66 0.018
cellular response to transforming growth factor beta stimulus GO:0071560 88 0.018
positive regulation of organelle organization GO:0010638 128 0.018
camera type eye development GO:0043010 266 0.018
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.018
epithelial tube morphogenesis GO:0060562 303 0.018
dna repair GO:0006281 107 0.018
leukocyte migration GO:0050900 124 0.018
double strand break repair GO:0006302 48 0.018
negative regulation of protein processing GO:0010955 79 0.018
meiotic cell cycle process GO:1903046 77 0.018
metencephalon development GO:0022037 89 0.018
regulation of cellular amine metabolic process GO:0033238 20 0.018
cellular component assembly involved in morphogenesis GO:0010927 139 0.018
cellular response to hormone stimulus GO:0032870 150 0.018
positive regulation of ras gtpase activity GO:0032320 65 0.017
cation transport GO:0006812 399 0.017
regulation of protein localization GO:0032880 231 0.017
chromosome segregation GO:0007059 48 0.017
cellular response to lipid GO:0071396 145 0.017
phagocytosis GO:0006909 66 0.017
regulation of cellular component biogenesis GO:0044087 181 0.017
tissue homeostasis GO:0001894 115 0.017
gastrulation GO:0007369 116 0.017
mitochondrion distribution GO:0048311 4 0.017
intracellular receptor signaling pathway GO:0030522 74 0.017
renal system development GO:0072001 225 0.017
regulation of cellular amino acid metabolic process GO:0006521 5 0.017
positive regulation of hydrolase activity GO:0051345 148 0.017
regulation of cellular component size GO:0032535 121 0.017
innate immune response GO:0045087 157 0.017
hindbrain development GO:0030902 128 0.016
positive regulation of proteolysis GO:0045862 85 0.016
nucleoside monophosphate metabolic process GO:0009123 85 0.016
establishment of protein localization to organelle GO:0072594 118 0.016
neuron apoptotic process GO:0051402 142 0.016
microtubule cytoskeleton organization GO:0000226 157 0.016
response to peptide GO:1901652 136 0.016
cellular response to growth factor stimulus GO:0071363 197 0.016
regulation of chromosome organization GO:0033044 83 0.016
development of primary sexual characteristics GO:0045137 143 0.016
germ cell development GO:0007281 185 0.016
negative regulation of molecular function GO:0044092 258 0.016
protein targeting GO:0006605 143 0.016
chemotaxis GO:0006935 247 0.016
negative regulation of phosphate metabolic process GO:0045936 184 0.016
glycoprotein metabolic process GO:0009100 116 0.016
negative regulation of mitotic cell cycle phase transition GO:1901991 45 0.016
vesicle coating GO:0006901 2 0.016
cell adhesion GO:0007155 329 0.016
embryonic epithelial tube formation GO:0001838 130 0.016
response to light stimulus GO:0009416 135 0.015
cation transmembrane transport GO:0098655 266 0.015
skeletal muscle organ development GO:0060538 163 0.015
cajal body organization GO:0030576 1 0.015
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.015
regulation of establishment of protein localization GO:0070201 181 0.015
cyclin catabolic process GO:0008054 1 0.015
cell division GO:0051301 120 0.015
organelle disassembly GO:1903008 2 0.015
muscle tissue development GO:0060537 308 0.015
purine nucleoside monophosphate catabolic process GO:0009128 58 0.015
epithelial cell development GO:0002064 159 0.015
muscle cell differentiation GO:0042692 261 0.015
single organismal cell cell adhesion GO:0016337 131 0.015
mitotic cytokinesis GO:0000281 4 0.015
cerebellum development GO:0021549 77 0.015
regulation of actin filament based process GO:0032970 99 0.015
regulation of metal ion transport GO:0010959 106 0.015
tube formation GO:0035148 140 0.015
metal ion homeostasis GO:0055065 189 0.015
gonad development GO:0008406 141 0.015
negative regulation of phosphorylation GO:0042326 166 0.015
coenzyme metabolic process GO:0006732 52 0.015
multicellular organismal signaling GO:0035637 91 0.014
cellular ketone metabolic process GO:0042180 84 0.014
microtubule based process GO:0007017 236 0.014
regulation of transferase activity GO:0051338 263 0.014
protein localization to membrane GO:0072657 108 0.014
organelle fission GO:0048285 170 0.014
regionalization GO:0003002 337 0.014
regulation of defense response GO:0031347 233 0.014
myosin filament organization GO:0031033 3 0.014
intrinsic apoptotic signaling pathway GO:0097193 132 0.014
establishment or maintenance of cell polarity GO:0007163 86 0.013
negative regulation of protein maturation GO:1903318 79 0.013
neuron death GO:0070997 154 0.013
regulation of translational initiation GO:0006446 15 0.013
inorganic cation transmembrane transport GO:0098662 207 0.013
t cell activation GO:0042110 289 0.013
striated muscle tissue development GO:0014706 293 0.013
negative regulation of proteolysis GO:0045861 74 0.013
negative regulation of intrinsic apoptotic signaling pathway GO:2001243 34 0.013
nuclear import GO:0051170 95 0.013
compound eye development GO:0048749 1 0.013
microtubule severing GO:0051013 5 0.013
eye photoreceptor cell differentiation GO:0001754 41 0.013
ameboidal type cell migration GO:0001667 128 0.013
negative regulation of mitotic cell cycle GO:0045930 58 0.013
negative regulation of dna replication GO:0008156 4 0.013
rhythmic process GO:0048511 174 0.013
cellular response to peptide hormone stimulus GO:0071375 92 0.013
protein import into nucleus GO:0006606 95 0.013
myosin filament assembly GO:0031034 2 0.013
regulation of ion transport GO:0043269 215 0.013
response to radiation GO:0009314 165 0.013
single organism nuclear import GO:1902593 95 0.012
mitotic cell cycle process GO:1903047 159 0.012
negative regulation of protein phosphorylation GO:0001933 126 0.012
endocytosis GO:0006897 168 0.012
negative regulation of immune system process GO:0002683 209 0.012
multicellular organismal protein catabolic process GO:0044254 1 0.012
locomotory behavior GO:0007626 195 0.012
organelle assembly GO:0070925 177 0.012
apoptotic signaling pathway GO:0097190 306 0.012
regulation of protein processing GO:0070613 96 0.012
digestive system development GO:0055123 200 0.012
carbohydrate metabolic process GO:0005975 230 0.012
sequestering of calcium ion GO:0051208 18 0.012
single organism cell adhesion GO:0098602 156 0.012
developmental growth involved in morphogenesis GO:0060560 138 0.012
cilium assembly GO:0042384 81 0.012
gene silencing by rna GO:0031047 19 0.012
stress activated mapk cascade GO:0051403 80 0.012
microtubule based transport GO:0010970 50 0.012
cation homeostasis GO:0055080 212 0.012
regulation of cellular protein catabolic process GO:1903362 61 0.012
amide transport GO:0042886 138 0.012
cellular response to cytokine stimulus GO:0071345 189 0.012
regulation of t cell activation GO:0050863 170 0.012
regulation of cell cycle phase transition GO:1901987 77 0.012
negative regulation of cell proliferation GO:0008285 296 0.012
myelination GO:0042552 74 0.012
cellular response to peptide GO:1901653 92 0.012
dendrite development GO:0016358 115 0.012
regulation of neuron apoptotic process GO:0043523 122 0.012
stress activated protein kinase signaling cascade GO:0031098 81 0.011
bmp signaling pathway GO:0030509 93 0.011
inorganic ion transmembrane transport GO:0098660 234 0.011
negative regulation of cellular catabolic process GO:0031330 47 0.011
gene silencing GO:0016458 38 0.011
regulation of protein complex assembly GO:0043254 83 0.011
limb development GO:0060173 166 0.011
epithelial cell proliferation GO:0050673 174 0.011
blastocyst development GO:0001824 80 0.011
chromatin organization GO:0006325 206 0.011
epithelial tube formation GO:0072175 130 0.011
regulation of protein oligomerization GO:0032459 4 0.011
translational initiation GO:0006413 24 0.011
transforming growth factor beta receptor signaling pathway GO:0007179 71 0.011
nucleus organization GO:0006997 45 0.011
positive regulation of cell motility GO:2000147 116 0.011
localization within membrane GO:0051668 4 0.011
nuclear transport GO:0051169 139 0.011
negative regulation of cell cycle process GO:0010948 69 0.011
regulation of secretion GO:0051046 274 0.011
glycoprotein biosynthetic process GO:0009101 89 0.011
regulation of stress activated mapk cascade GO:0032872 69 0.011
response to insulin GO:0032868 100 0.011
protein homooligomerization GO:0051260 43 0.011
protein digestion GO:0044256 1 0.011
determination of adult lifespan GO:0008340 11 0.011
stem cell differentiation GO:0048863 268 0.011
cytokinetic process GO:0032506 2 0.011
negative regulation of nervous system development GO:0051961 156 0.011
lipid storage GO:0019915 36 0.011
nucleoside monophosphate catabolic process GO:0009125 59 0.011
regulation of ion transmembrane transport GO:0034765 119 0.011
regulation of neuron death GO:1901214 134 0.011
adult locomotory behavior GO:0008344 91 0.011
protein import GO:0017038 101 0.011
positive regulation of growth GO:0045927 104 0.010
phospholipid metabolic process GO:0006644 87 0.010
regulation of homeostatic process GO:0032844 182 0.010
ribonucleoprotein complex disassembly GO:0032988 3 0.010
gliogenesis GO:0042063 141 0.010
wnt signaling pathway GO:0016055 188 0.010
spermatid development GO:0007286 108 0.010
metaphase plate congression GO:0051310 2 0.010
divalent metal ion transport GO:0070838 172 0.010
response to lipopolysaccharide GO:0032496 128 0.010

Psme4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.022
amino acid metabolic disorder DOID:9252 0 0.022
inherited metabolic disorder DOID:655 0 0.022
organic acidemia DOID:0060159 0 0.022
disease of cellular proliferation DOID:14566 0 0.017
disease of anatomical entity DOID:7 0 0.016
musculoskeletal system disease DOID:17 0 0.016
cancer DOID:162 0 0.015
organ system cancer DOID:0050686 0 0.015
nervous system disease DOID:863 0 0.014
muscular disease DOID:0080000 0 0.014
immune system disease DOID:2914 0 0.011