Mus musculus

440 known processes

Pten

phosphatase and tensin homolog

(Aliases: TEP1,B430203M17Rik,MMAC1,2310035O07Rik,A130070J02Rik,MGC183880,AI463227)

Pten biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regionalization GO:0003002 337 1.000
positive regulation of apoptotic signaling pathway GO:2001235 95 1.000
protein localization to organelle GO:0033365 185 1.000
Worm
positive regulation of protein modification process GO:0031401 299 1.000
cellular response to dna damage stimulus GO:0006974 207 1.000
negative regulation of epithelial cell proliferation GO:0050680 64 1.000
cell fate commitment GO:0045165 210 1.000
Fly
protein localization to nucleus GO:0034504 121 1.000
Worm
regulation of cellular ketone metabolic process GO:0010565 66 1.000
epithelial cell proliferation GO:0050673 174 1.000
urogenital system development GO:0001655 261 1.000
regulation of dna templated transcription in response to stress GO:0043620 9 1.000
regulation of cellular amine metabolic process GO:0033238 20 1.000
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 1.000
Human
b cell differentiation GO:0030183 78 1.000
skin development GO:0043588 220 1.000
regulation of cell cycle GO:0051726 281 1.000
regulation of transcription from rna polymerase ii promoter in response to stress GO:0043618 8 1.000
lymphocyte differentiation GO:0030098 242 1.000
epidermis development GO:0008544 187 1.000
ovarian follicle development GO:0001541 40 1.000
negative regulation of protein phosphorylation GO:0001933 126 1.000
Human
positive regulation of apoptotic process GO:0043065 217 1.000
mesonephric tubule development GO:0072164 94 1.000
regulation of cellular amino acid metabolic process GO:0006521 5 1.000
positive regulation of macroautophagy GO:0016239 3 1.000
columnar cuboidal epithelial cell differentiation GO:0002065 82 1.000
regulation of cellular response to stress GO:0080135 159 1.000
Fly
negative regulation of protein metabolic process GO:0051248 282 1.000
Human
respiratory system development GO:0060541 190 1.000
Fly
spermatogenesis GO:0007283 284 1.000
cellular senescence GO:0090398 11 1.000
regulation of leukocyte differentiation GO:1902105 159 1.000
glial cell apoptotic process GO:0034349 3 1.000
regulation of myeloid leukocyte differentiation GO:0002761 58 1.000
cellular response to radiation GO:0071478 28 1.000
cellular response to starvation GO:0009267 57 1.000
apoptotic signaling pathway GO:0097190 306 1.000
positive regulation of growth GO:0045927 104 1.000
negative regulation of macroautophagy GO:0016242 5 1.000
respiratory tube development GO:0030323 167 1.000
carbon catabolite activation of transcription GO:0045991 4 1.000
macroautophagy GO:0016236 21 1.000
cellular response to gamma radiation GO:0071480 4 1.000
dna metabolic process GO:0006259 303 1.000
protein autophosphorylation GO:0046777 61 1.000
gland development GO:0048732 330 1.000
epithelial tube morphogenesis GO:0060562 303 1.000
embryonic organ morphogenesis GO:0048562 276 1.000
protein import into nucleus GO:0006606 95 1.000
Worm
negative regulation of cellular protein metabolic process GO:0032269 247 1.000
Human
regulation of cell morphogenesis involved in differentiation GO:0010769 151 1.000
cellular ketone metabolic process GO:0042180 84 1.000
b cell activation GO:0042113 161 1.000
regulation of kinase activity GO:0043549 249 1.000
Human
erythrocyte differentiation GO:0030218 88 1.000
regulation of mapk cascade GO:0043408 248 1.000
leukocyte differentiation GO:0002521 342 1.000
negative regulation of phosphatidylinositol 3 kinase activity GO:0043553 1 1.000
positive regulation of programmed cell death GO:0043068 218 1.000
establishment of protein localization to organelle GO:0072594 118 1.000
Worm
positive regulation of transcription by galactose GO:0000411 1 1.000
kidney development GO:0001822 213 1.000
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 68 1.000
Human
positive regulation of apoptotic process involved in mammary gland involution GO:0060058 4 1.000
immune response activating signal transduction GO:0002757 116 1.000
male gamete generation GO:0048232 285 1.000
negative regulation of cell proliferation GO:0008285 296 1.000
lung development GO:0030324 164 1.000
positive regulation of glial cell proliferation GO:0060252 4 1.000
organ growth GO:0035265 117 1.000
digestive tract morphogenesis GO:0048546 147 0.999
Zebrafish
mapk cascade GO:0000165 281 0.999
response to starvation GO:0042594 65 0.999
Fly
response to nutrient levels GO:0031667 109 0.999
Fly
regulation of canonical wnt signaling pathway GO:0060828 82 0.999
molting cycle GO:0042303 90 0.999
cellular response to nutrient levels GO:0031669 64 0.999
response to peptide GO:1901652 136 0.999
Fly
multicellular organism growth GO:0035264 161 0.999
Fly
regulation of bmp signaling pathway GO:0030510 60 0.999
positive regulation of nervous system development GO:0051962 221 0.999
regulation of protein import into nucleus GO:0042306 52 0.999
Worm
regulation of transferase activity GO:0051338 263 0.999
stem cell development GO:0048864 219 0.999
negative regulation of transcription involved in g1 s transition of mitotic cell cycle GO:0071930 1 0.999
intrinsic apoptotic signaling pathway GO:0097193 132 0.999
cellular amine metabolic process GO:0044106 44 0.999
positive regulation of neuron differentiation GO:0045666 141 0.999
negative regulation of protein modification process GO:0031400 163 0.999
Human
female sex differentiation GO:0046660 84 0.999
nuclear transport GO:0051169 139 0.999
Worm
cellular response to lipid GO:0071396 145 0.999
response to decreased oxygen levels GO:0036293 59 0.999
cellular response to external stimulus GO:0071496 88 0.999
germ cell development GO:0007281 185 0.999
amine metabolic process GO:0009308 45 0.999
carbohydrate metabolic process GO:0005975 230 0.999
Human
prostate gland development GO:0030850 48 0.999
keratinocyte differentiation GO:0030216 48 0.999
bmp signaling pathway GO:0030509 93 0.999
dna damage response signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 2 0.999
response to ionizing radiation GO:0010212 42 0.999
cell aging GO:0007569 35 0.999
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902043 13 0.999
negative regulation of growth GO:0045926 99 0.999
negative regulation of phosphorus metabolic process GO:0010563 184 0.999
Human
cellular protein catabolic process GO:0044257 155 0.999
positive regulation of dendrite development GO:1900006 21 0.999
stem cell maintenance GO:0019827 130 0.999
mitochondrial dna repair GO:0043504 3 0.999
negative regulation of cellular amine metabolic process GO:0033239 1 0.999
appendage morphogenesis GO:0035107 149 0.999
appendage development GO:0048736 166 0.999
cellular response to extracellular stimulus GO:0031668 81 0.998
cytoplasmic transport GO:0016482 234 0.998
Worm
development of primary sexual characteristics GO:0045137 143 0.998
regulation of neuron differentiation GO:0045664 281 0.998
positive regulation of transcription from rna polymerase ii promoter in response to stress GO:0036003 3 0.998
regulation of keratinocyte differentiation GO:0045616 11 0.998
positive regulation of cell death GO:0010942 224 0.998
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 34 0.998
regulation of binding GO:0051098 111 0.998
antral ovarian follicle growth GO:0001547 5 0.998
muscle tissue development GO:0060537 308 0.998
mechanoreceptor differentiation GO:0042490 67 0.998
positive regulation of innate immune response GO:0045089 80 0.998
regulation of epithelial cell proliferation GO:0050678 141 0.998
telencephalon development GO:0021537 186 0.998
skeletal system development GO:0001501 356 0.998
positive regulation of lymphocyte apoptotic process GO:0070230 13 0.998
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.998
regulation of lipid kinase activity GO:0043550 14 0.998
inner ear receptor cell differentiation GO:0060113 61 0.998
axonogenesis GO:0007409 274 0.998
morphogenesis of a branching structure GO:0001763 203 0.998
leukocyte proliferation GO:0070661 172 0.998
spermatid differentiation GO:0048515 115 0.998
negative regulation of lipid kinase activity GO:0090219 1 0.998
cellular response to light stimulus GO:0071482 19 0.997
regulation of protein kinase activity GO:0045859 232 0.997
Human
extrinsic apoptotic signaling pathway GO:0097191 126 0.997
regulation of apoptotic signaling pathway GO:2001233 197 0.997
stem cell proliferation GO:0072089 117 0.997
positive regulation of mitotic sister chromatid separation GO:1901970 2 0.997
female genitalia morphogenesis GO:0048807 3 0.997
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 40 0.997
cellular response to drug GO:0035690 15 0.997
response to osmotic stress GO:0006970 21 0.997
positive regulation of nitric oxide synthase activity GO:0051000 2 0.997
neural tube development GO:0021915 160 0.997
regulation of lymphocyte proliferation GO:0050670 117 0.997
cerebellum development GO:0021549 77 0.997
rhythmic process GO:0048511 174 0.997
positive regulation of kinase activity GO:0033674 155 0.997
peptidyl amino acid modification GO:0018193 336 0.997
striated muscle tissue development GO:0014706 293 0.997
positive regulation of cell development GO:0010720 237 0.997
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.997
regulation of cell adhesion GO:0030155 154 0.997
Human
limb development GO:0060173 166 0.997
gonad development GO:0008406 141 0.997
positive regulation of cell proliferation involved in heart valve morphogenesis GO:0003251 1 0.997
positive regulation of release of cytochrome c from mitochondria GO:0090200 5 0.997
activation of mapkk activity GO:0000186 15 0.997
positive regulation of bmp signaling pathway GO:0030513 23 0.997
signal transduction by p53 class mediator GO:0072331 51 0.997
negative regulation of cell growth GO:0030308 44 0.997
lymphocyte homeostasis GO:0002260 64 0.997
negative regulation of photoreceptor cell differentiation GO:0046533 4 0.996
regulation of organ morphogenesis GO:2000027 144 0.996
Fly
positive regulation of intracellular transport GO:0032388 70 0.996
ear development GO:0043583 200 0.996
Zebrafish
ovulation cycle GO:0042698 59 0.996
defense response to other organism GO:0098542 197 0.996
ureteric bud development GO:0001657 94 0.996
lung induction GO:0060492 3 0.996
extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 34 0.996
peptidyl serine modification GO:0018209 83 0.996
negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 26 0.996
morphogenesis of a branching epithelium GO:0061138 193 0.996
mammary gland epithelium development GO:0061180 65 0.995
lateral inhibition GO:0046331 1 0.995
cell cell signaling involved in cell fate commitment GO:0045168 35 0.995
hair cycle GO:0042633 90 0.995
myeloid cell differentiation GO:0030099 233 0.995
Zebrafish
regulation of cell cycle process GO:0010564 160 0.995
negative regulation of phosphate metabolic process GO:0045936 184 0.995
Human
regulation of macroautophagy GO:0016241 12 0.995
chondrocyte differentiation GO:0002062 72 0.995
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 31 0.995
regulation of myeloid cell differentiation GO:0045637 96 0.995
embryonic appendage morphogenesis GO:0035113 126 0.995
immature b cell differentiation GO:0002327 10 0.995
positive regulation of mapk cascade GO:0043410 170 0.995
negative regulation of cyclin dependent protein serine threonine kinase activity GO:0045736 9 0.995
Human
response to peptide hormone GO:0043434 127 0.995
Fly
regulation of protein transport GO:0051223 163 0.995
Worm
ossification GO:0001503 216 0.995
prostate glandular acinus development GO:0060525 12 0.995
positive regulation of reactive oxygen species metabolic process GO:2000379 11 0.994
homeostasis of number of cells GO:0048872 210 0.994
peptidyl serine phosphorylation GO:0018105 74 0.994
branching morphogenesis of an epithelial tube GO:0048754 159 0.994
neuron apoptotic process GO:0051402 142 0.994
digestive tract development GO:0048565 190 0.994
Zebrafish
regulation of mitotic cell cycle GO:0007346 126 0.994
hepaticobiliary system development GO:0061008 67 0.994
negative regulation of anoikis GO:2000811 2 0.994
axon guidance GO:0007411 141 0.994
cellular response to acid chemical GO:0071229 68 0.994
synaptic transmission GO:0007268 329 0.993
regulation of protein localization GO:0032880 231 0.993
Worm
positive regulation of cholesterol transport GO:0032376 9 0.993
regulation of protein serine threonine kinase activity GO:0071900 157 0.993
Human
negative regulation of glial cell proliferation GO:0060253 4 0.993
keratinocyte proliferation GO:0043616 21 0.993
female gonad development GO:0008585 71 0.993
liver development GO:0001889 66 0.993
mitotic cell cycle arrest GO:0071850 4 0.993
regulation of lymphocyte differentiation GO:0045619 107 0.993
photoreceptor cell differentiation GO:0046530 52 0.993
Fly
angiogenesis GO:0001525 201 0.993
cellular amino acid metabolic process GO:0006520 103 0.993
t cell differentiation GO:0030217 174 0.993
epithelial cell differentiation involved in prostate gland development GO:0060742 13 0.993
sertoli cell differentiation GO:0060008 18 0.993
regulation of cellular component size GO:0032535 121 0.992
signal transduction involved in dna integrity checkpoint GO:0072401 3 0.992
release of cytochrome c from mitochondria GO:0001836 23 0.992
response to organic cyclic compound GO:0014070 198 0.992
renal system development GO:0072001 225 0.992
anatomical structure homeostasis GO:0060249 145 0.992
regulation of cellular catabolic process GO:0031329 242 0.992
regulation of reactive oxygen species metabolic process GO:2000377 40 0.992
response to oxidative stress GO:0006979 123 0.992
embryonic limb morphogenesis GO:0030326 126 0.991
gastrulation GO:0007369 116 0.991
Zebrafish
negative regulation of cell cycle GO:0045786 123 0.991
Human
positive regulation of leukocyte apoptotic process GO:2000108 21 0.991
regulation of map kinase activity GO:0043405 120 0.991
positive regulation of leukocyte differentiation GO:1902107 86 0.991
intracellular protein transport GO:0006886 204 0.991
Worm
fatty acid metabolic process GO:0006631 121 0.991
positive regulation of striated muscle cell apoptotic process GO:0010663 3 0.991
response to hypoxia GO:0001666 58 0.990
t cell activation GO:0042110 289 0.990
regulation of protein stability GO:0031647 52 0.990
Human
regulation of homeostatic process GO:0032844 182 0.990
positive regulation of mitotic metaphase anaphase transition GO:0045842 2 0.990
regulation of nucleocytoplasmic transport GO:0046822 73 0.989
Worm
lymphocyte apoptotic process GO:0070227 54 0.989
maternal placenta development GO:0001893 20 0.989
fibroblast proliferation GO:0048144 35 0.989
apoptotic process involved in mammary gland involution GO:0060057 4 0.989
purine containing compound metabolic process GO:0072521 311 0.988
calcium ion homeostasis GO:0055074 127 0.988
lipid biosynthetic process GO:0008610 179 0.988
positive regulation of transcription from rna polymerase ii promoter involved in cellular response to chemical stimulus GO:1901522 7 0.988
learning or memory GO:0007611 148 0.987
regulation of mitotic cell cycle phase transition GO:1901990 73 0.987
cartilage condensation GO:0001502 18 0.987
positive regulation of autophagy GO:0010508 9 0.987
nitrogen compound transport GO:0071705 271 0.987
neuron projection guidance GO:0097485 141 0.987
regulation of anatomical structure size GO:0090066 178 0.987
protein catabolic process GO:0030163 221 0.987
epithelial cell development GO:0002064 159 0.986
muscle cell differentiation GO:0042692 261 0.986
prostate gland epithelium morphogenesis GO:0060740 31 0.986
skeletal system morphogenesis GO:0048705 203 0.986
regulation of intracellular transport GO:0032386 159 0.986
Worm
cellular response to oxidative stress GO:0034599 76 0.985
negative regulation of leukocyte proliferation GO:0070664 46 0.985
camera type eye development GO:0043010 266 0.985
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.985
reactive oxygen species metabolic process GO:0072593 84 0.985
dna damage checkpoint GO:0000077 26 0.984
connective tissue development GO:0061448 179 0.984
dendrite development GO:0016358 115 0.984
negative regulation of kinase activity GO:0033673 81 0.984
Human
photoreceptor cell morphogenesis GO:0008594 3 0.983
positive regulation of map kinase activity GO:0043406 84 0.983
autophagy GO:0006914 45 0.983
Fly
carbon catabolite regulation of transcription GO:0045990 4 0.983
regulation of muscle tissue development GO:1901861 97 0.983
positive regulation of rac protein signal transduction GO:0035022 1 0.983
regulation of intrinsic apoptotic signaling pathway GO:2001242 61 0.983
response to radiation GO:0009314 165 0.983
positive regulation of transferase activity GO:0051347 167 0.982
response to oxygen levels GO:0070482 62 0.982
negative regulation of mitotic cell cycle GO:0045930 58 0.982
Human
myeloid leukocyte differentiation GO:0002573 119 0.982
negative regulation of apoptotic signaling pathway GO:2001234 104 0.982
purine nucleoside metabolic process GO:0042278 241 0.981
negative regulation of map kinase activity GO:0043407 34 0.981
sensory organ morphogenesis GO:0090596 242 0.981
Fly
canonical wnt signaling pathway GO:0060070 130 0.980
Human
positive regulation of cardiac muscle cell apoptotic process GO:0010666 3 0.980
regulation of peptidyl serine phosphorylation GO:0033135 39 0.980
positive regulation of intrinsic apoptotic signaling pathway GO:2001244 25 0.980
regulation of b cell differentiation GO:0045577 23 0.980
cellular macromolecule catabolic process GO:0044265 206 0.980
regulation of organelle organization GO:0033043 289 0.980
regulation of intracellular protein transport GO:0033157 82 0.979
Worm
response to growth factor GO:0070848 198 0.979
regulation of autophagy GO:0010506 30 0.979
Fly
positive regulation of cell morphogenesis involved in differentiation GO:0010770 72 0.979
hindbrain development GO:0030902 128 0.979
positive regulation of cellular amine metabolic process GO:0033240 5 0.979
female gamete generation GO:0007292 74 0.979
embryonic skeletal system development GO:0048706 120 0.979
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.978
negative regulation of protein serine threonine kinase activity GO:0071901 49 0.978
Human
kidney epithelium development GO:0072073 121 0.978
regulation of epidermal cell differentiation GO:0045604 21 0.978
skeletal muscle organ development GO:0060538 163 0.977
cellular response to abiotic stimulus GO:0071214 56 0.977
positive regulation of protein kinase activity GO:0045860 144 0.977
phagocytosis GO:0006909 66 0.977
regulation of cell aging GO:0090342 9 0.977
dna damage response signal transduction by p53 class mediator GO:0030330 19 0.976
regulation of osteoblast differentiation GO:0045667 67 0.976
mesonephric epithelium development GO:0072163 94 0.976
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.976
negative regulation of t cell proliferation GO:0042130 38 0.976
regulation of neuron apoptotic process GO:0043523 122 0.976
protein modification by small protein conjugation or removal GO:0070647 207 0.975
response to extracellular stimulus GO:0009991 127 0.975
Fly
nephron tubule development GO:0072080 84 0.975
purine ribonucleotide metabolic process GO:0009150 290 0.975
peptidyl threonine phosphorylation GO:0018107 31 0.975
regulation of transforming growth factor beta2 production GO:0032909 2 0.975
lateral mesodermal cell differentiation GO:0048371 3 0.974
negative regulation of phosphorylation GO:0042326 166 0.974
Human
engulfment of apoptotic cell GO:0043652 3 0.974
regulation of neuron projection development GO:0010975 169 0.973
clara cell differentiation GO:0060486 4 0.973
chondrocyte development GO:0002063 24 0.973
activation of cysteine type endopeptidase activity involved in apoptotic signaling pathway GO:0097296 2 0.973
positive regulation of sterol transport GO:0032373 9 0.973
smoothened signaling pathway GO:0007224 105 0.973
chromatin organization GO:0006325 206 0.973
cellular response to x ray GO:0071481 2 0.972
endocrine system development GO:0035270 98 0.972
single organism nuclear import GO:1902593 95 0.972
Worm
embryonic heart tube morphogenesis GO:0003143 51 0.972
chromatin modification GO:0016568 187 0.972
response to drug GO:0042493 75 0.971
regulation of fibroblast proliferation GO:0048145 34 0.971
hair follicle morphogenesis GO:0031069 29 0.970
monocarboxylic acid metabolic process GO:0032787 191 0.970
regulation of protein deacetylation GO:0090311 17 0.970
lymphocyte proliferation GO:0046651 164 0.969
regulation of fat cell differentiation GO:0045598 81 0.969
regulation of chemotaxis GO:0050920 53 0.969
Worm
cell growth GO:0016049 130 0.968
purine nucleotide metabolic process GO:0006163 302 0.968
regulation of dna replication GO:0006275 17 0.968
cell cycle checkpoint GO:0000075 47 0.968
regulation of osteoclast differentiation GO:0045670 36 0.968
genitalia development GO:0048806 37 0.967
negative regulation of bmp signaling pathway GO:0030514 35 0.967
erk1 and erk2 cascade GO:0070371 77 0.967
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 56 0.967
response to alcohol GO:0097305 48 0.967
hindlimb morphogenesis GO:0035137 42 0.967
metencephalon development GO:0022037 89 0.967
negative regulation of immature t cell proliferation GO:0033087 3 0.966
regulation of mesenchymal cell proliferation GO:0010464 37 0.966
regulation of membrane potential GO:0042391 192 0.965
foregut regionalization GO:0060423 3 0.965
positive regulation of neuron apoptotic process GO:0043525 25 0.965
protein targeting GO:0006605 143 0.965
Worm
nucleocytoplasmic transport GO:0006913 139 0.964
Worm
chemotaxis GO:0006935 247 0.964
Worm
regulation of cell cycle phase transition GO:1901987 77 0.963
regulation of response to wounding GO:1903034 189 0.963
Fly
positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator GO:1902255 2 0.962
posttranscriptional regulation of gene expression GO:0010608 155 0.962
Human
tissue remodeling GO:0048771 102 0.961
response to insulin GO:0032868 100 0.961
Fly
maternal process involved in female pregnancy GO:0060135 32 0.961
cardiac endothelial cell differentiation GO:0003348 4 0.960
neuronal action potential GO:0019228 54 0.960
cellular response to growth factor stimulus GO:0071363 197 0.960
divalent inorganic cation transport GO:0072511 178 0.960
b cell lineage commitment GO:0002326 4 0.960
epidermis morphogenesis GO:0048730 33 0.960
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 57 0.959
cation transport GO:0006812 399 0.959
circulatory system process GO:0003013 197 0.959
adaptive immune response GO:0002250 155 0.959
calcium ion transport GO:0006816 159 0.958
embryonic placenta development GO:0001892 98 0.957
multicellular organismal homeostasis GO:0048871 164 0.957
intra s dna damage checkpoint GO:0031573 4 0.957
positive regulation of protein phosphorylation GO:0001934 242 0.957
canonical wnt signaling pathway involved in heart development GO:0061316 3 0.957
schwann cell proliferation GO:0014010 2 0.957
macromolecule catabolic process GO:0009057 281 0.956
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 45 0.956
anterior commissure morphogenesis GO:0021960 6 0.955
regulation of feeding behavior GO:0060259 3 0.955
cation homeostasis GO:0055080 212 0.955
mesenchyme development GO:0060485 152 0.955
divalent metal ion transport GO:0070838 172 0.955
immune response activating cell surface receptor signaling pathway GO:0002429 72 0.955
stem cell differentiation GO:0048863 268 0.955
negative regulation of leukocyte differentiation GO:1902106 51 0.954
cardiac muscle tissue development GO:0048738 130 0.953
negative regulation of protein processing GO:0010955 79 0.952
regulation of organ growth GO:0046620 61 0.952
positive regulation of cell migration GO:0030335 109 0.952
regulation of stress activated mapk cascade GO:0032872 69 0.952
central nervous system neuron differentiation GO:0021953 162 0.952
determination of adult lifespan GO:0008340 11 0.951
Worm
regulation of smad protein import into nucleus GO:0060390 3 0.950
retina development in camera type eye GO:0060041 119 0.949
osteoblast development GO:0002076 17 0.949
purine containing compound biosynthetic process GO:0072522 70 0.949
neuron death GO:0070997 154 0.949
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.948
regulation of cell projection organization GO:0031344 206 0.948
cell type specific apoptotic process GO:0097285 268 0.947
immune response regulating signaling pathway GO:0002764 125 0.947
stress activated protein kinase signaling cascade GO:0031098 81 0.947
carbon catabolite activation of transcription from rna polymerase ii promoter GO:0000436 4 0.947
hair follicle development GO:0001942 85 0.947
cellular calcium ion homeostasis GO:0006874 119 0.946
positive regulation of stem cell proliferation GO:2000648 59 0.946
regulation of cell migration involved in sprouting angiogenesis GO:0090049 4 0.945
regulation of chromatin modification GO:1903308 57 0.945
regulation of transcription by galactose GO:0000409 1 0.944
thymocyte apoptotic process GO:0070242 19 0.944
cellular response to retinoic acid GO:0071300 25 0.944
ribonucleotide metabolic process GO:0009259 291 0.943
canonical wnt signaling pathway involved in regulation of cell proliferation GO:0044340 3 0.943
response to amino acid GO:0043200 37 0.942
regulation of ion transport GO:0043269 215 0.942
regulation of cytoplasmic transport GO:1903649 112 0.942
Worm
negative regulation of intrinsic apoptotic signaling pathway GO:2001243 34 0.942
negative regulation of neuron death GO:1901215 98 0.941
mammary gland branching involved in pregnancy GO:0060745 6 0.941
lateral mesoderm morphogenesis GO:0048369 3 0.941
neural tube closure GO:0001843 90 0.940
embryonic hemopoiesis GO:0035162 23 0.940
negative regulation of neuron apoptotic process GO:0043524 92 0.939
epithelial cell proliferation involved in prostate gland development GO:0060767 11 0.939
cholesterol homeostasis GO:0042632 44 0.939
metal ion homeostasis GO:0055065 189 0.939
peptidyl threonine modification GO:0018210 31 0.938
morphogenesis of embryonic epithelium GO:0016331 159 0.938
intracellular steroid hormone receptor signaling pathway GO:0030518 29 0.938
activation of adenylate cyclase activity GO:0007190 4 0.938
intracellular signal transduction involved in g1 dna damage checkpoint GO:1902400 3 0.938
cerebellum morphogenesis GO:0021587 42 0.937
proteasomal protein catabolic process GO:0010498 98 0.936
alpha beta t cell differentiation GO:0046632 69 0.936
stress induced premature senescence GO:0090400 2 0.935
negative regulation of immune system process GO:0002683 209 0.935
forebrain development GO:0030900 302 0.934
programmed necrotic cell death GO:0097300 28 0.932
regulation of purine nucleotide biosynthetic process GO:1900371 34 0.932
positive regulation of glial cell differentiation GO:0045687 21 0.932
small molecule biosynthetic process GO:0044283 132 0.931
organic hydroxy compound metabolic process GO:1901615 203 0.931
Human Fly
negative regulation of jun kinase activity GO:0043508 9 0.930
cognition GO:0050890 149 0.929
positive regulation of b cell proliferation GO:0030890 24 0.929
regulation of epithelial cell migration GO:0010632 35 0.929
type i pneumocyte differentiation GO:0060509 7 0.928
negative regulation of organ growth GO:0046621 17 0.927
neuroblast proliferation GO:0007405 49 0.927
divalent inorganic cation homeostasis GO:0072507 138 0.927
regulation of protein targeting GO:1903533 61 0.926
Worm
regulation of t cell differentiation GO:0045580 83 0.926
ensheathment of neurons GO:0007272 76 0.926
immune response regulating cell surface receptor signaling pathway GO:0002768 80 0.926
positive regulation of osteoblast differentiation GO:0045669 34 0.925
regulation of cellular senescence GO:2000772 6 0.925

Pten disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 0 1.000
Human
thoracic cancer DOID:5093 0 0.999
cancer DOID:162 0 0.999
Human
organ system cancer DOID:0050686 0 0.999
Human
large intestine cancer DOID:5672 0 0.998
colon cancer DOID:219 0 0.998
gastrointestinal system cancer DOID:3119 0 0.998
intestinal cancer DOID:10155 0 0.998
colorectal cancer DOID:9256 0 0.998
liver carcinoma DOID:686 0 0.994
liver cancer DOID:3571 0 0.994
endocrine gland cancer DOID:170 0 0.992
Human
pancreatic cancer DOID:1793 0 0.989
breast cancer DOID:1612 0 0.985
respiratory system cancer DOID:0050615 0 0.985
hepatocellular carcinoma DOID:684 0 0.943