Mus musculus

291 known processes

Ptpn11

protein tyrosine phosphatase, non-receptor type 11

(Aliases: AW536184,PTP1D,2700084A17Rik,PTP2C,Shp2,SAP-2,SHP-2,Syp,SH-PTP3,SH-PTP2)

Ptpn11 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
tyrosine phosphorylation of stat5 protein GO:0042506 9 1.000
regulation of transferase activity GO:0051338 263 1.000
embryonic placenta development GO:0001892 98 1.000
t cell activation GO:0042110 289 0.999
Mouse
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.999
negative regulation of t cell proliferation GO:0042130 38 0.999
Mouse
regulation of mapk cascade GO:0043408 248 0.999
regulation of cellular ketone metabolic process GO:0010565 66 0.999
cellular ketone metabolic process GO:0042180 84 0.999
olfactory learning GO:0008355 2 0.998
myelination in peripheral nervous system GO:0022011 19 0.998
cardiac muscle tissue development GO:0048738 130 0.998
regulation of cellular amine metabolic process GO:0033238 20 0.998
layer formation in cerebral cortex GO:0021819 13 0.998
stem cell development GO:0048864 219 0.998
amine metabolic process GO:0009308 45 0.998
regulation of protein kinase activity GO:0045859 232 0.997
muscle tissue development GO:0060537 308 0.997
cellular amine metabolic process GO:0044106 44 0.997
regulation of erk1 and erk2 cascade GO:0070372 71 0.997
regulation of jak stat cascade GO:0046425 34 0.996
regulation of lymphocyte proliferation GO:0050670 117 0.996
Mouse
positive regulation of glial cell proliferation GO:0060252 4 0.996
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.996
synaptic transmission GO:0007268 329 0.996
regulation of receptor activity GO:0010469 41 0.996
positive regulation of mapk cascade GO:0043410 170 0.996
cytokine mediated signaling pathway GO:0019221 115 0.995
negative regulation of immature t cell proliferation GO:0033087 3 0.994
ras protein signal transduction GO:0007265 77 0.994
regulation of kinase activity GO:0043549 249 0.994
regulation of lymphocyte differentiation GO:0045619 107 0.994
Mouse
labyrinthine layer development GO:0060711 49 0.993
dna metabolic process GO:0006259 303 0.993
positive regulation of map kinase activity GO:0043406 84 0.993
peptidyl amino acid modification GO:0018193 336 0.993
Mouse
small gtpase mediated signal transduction GO:0007264 97 0.993
cardiocyte differentiation GO:0035051 87 0.993
epithelial cell development GO:0002064 159 0.992
Fly
negative regulation of epithelial cell proliferation GO:0050680 64 0.992
ventricular septum morphogenesis GO:0060412 27 0.992
carbon catabolite activation of transcription GO:0045991 4 0.992
regulation of protein serine threonine kinase activity GO:0071900 157 0.991
negative regulation of cell proliferation GO:0008285 296 0.991
Mouse
regulation of leukocyte differentiation GO:1902105 159 0.991
Mouse
jak stat cascade GO:0007259 42 0.991
cellular response to hormone stimulus GO:0032870 150 0.991
activation of mapk activity involved in innate immune response GO:0035419 2 0.990
heart trabecula formation GO:0060347 14 0.990
stem cell maintenance GO:0019827 130 0.990
regulation of secretion GO:0051046 274 0.990
response to organonitrogen compound GO:0010243 246 0.989
Human
regulation of t cell activation GO:0050863 170 0.989
Mouse
erbb signaling pathway GO:0038127 32 0.988
mapk cascade GO:0000165 281 0.988
muscle cell proliferation GO:0033002 52 0.987
regulation of lymphocyte activation GO:0051249 240 0.987
Mouse
axon ensheathment GO:0008366 76 0.987
lactation GO:0007595 25 0.987
negative regulation of anoikis GO:2000811 2 0.987
mesenchyme development GO:0060485 152 0.987
negative regulation of protein phosphorylation GO:0001933 126 0.986
Mouse
leukocyte differentiation GO:0002521 342 0.986
Mouse
neuron migration GO:0001764 122 0.986
positive regulation of kinase activity GO:0033674 155 0.986
gland development GO:0048732 330 0.986
blood vessel morphogenesis GO:0048514 285 0.985
regulation of cellular amino acid metabolic process GO:0006521 5 0.985
t cell proliferation GO:0042098 120 0.985
Mouse
positive regulation of growth GO:0045927 104 0.984
ensheathment of neurons GO:0007272 76 0.983
clara cell differentiation GO:0060486 4 0.983
carbon catabolite activation of transcription from rna polymerase ii promoter GO:0000436 4 0.983
rac protein signal transduction GO:0016601 13 0.983
stem cell differentiation GO:0048863 268 0.983
cellular amino acid metabolic process GO:0006520 103 0.983
regulation of protein targeting GO:1903533 61 0.983
negative regulation of peptidyl tyrosine phosphorylation GO:0050732 17 0.982
Mouse
mitral valve morphogenesis GO:0003183 4 0.981
gliogenesis GO:0042063 141 0.980
myelination GO:0042552 74 0.980
cardiac chamber development GO:0003205 108 0.980
response to peptide hormone GO:0043434 127 0.980
Human
formation of radial glial scaffolds GO:0021943 4 0.978
peptidyl tyrosine phosphorylation GO:0018108 143 0.978
Mouse
endodermal cell fate specification GO:0001714 4 0.977
heart trabecula morphogenesis GO:0061384 26 0.976
fibroblast growth factor receptor signaling pathway GO:0008543 46 0.976
Fly
striated muscle tissue development GO:0014706 293 0.975
organ growth GO:0035265 117 0.975
cardiac muscle cell differentiation GO:0055007 69 0.974
peptidyl tyrosine modification GO:0018212 145 0.974
Mouse
epithelial tube morphogenesis GO:0060562 303 0.973
Zebrafish
myeloid cell differentiation GO:0030099 233 0.973
regulation of t cell differentiation GO:0045580 83 0.973
epidermal growth factor receptor signaling pathway GO:0007173 28 0.973
positive regulation of transferase activity GO:0051347 167 0.972
pyramidal neuron migration GO:0021852 1 0.972
schwann cell differentiation GO:0014037 26 0.972
striated muscle cell proliferation GO:0014855 39 0.971
cardioblast migration to the midline involved in heart field formation GO:0060975 1 0.971
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902043 13 0.971
muscle cell differentiation GO:0042692 261 0.971
morphogenesis of a branching structure GO:0001763 203 0.970
platelet derived growth factor receptor signaling pathway GO:0048008 32 0.970
negative regulation of cellular protein metabolic process GO:0032269 247 0.970
Mouse
learning or memory GO:0007611 148 0.970
regulation of secretion by cell GO:1903530 249 0.969
oocyte axis specification GO:0007309 2 0.969
response to insulin GO:0032868 100 0.968
Human
positive regulation of cardioblast differentiation GO:0051891 3 0.968
axon guidance GO:0007411 141 0.967
urogenital system development GO:0001655 261 0.966
cellular response to growth factor stimulus GO:0071363 197 0.965
placenta development GO:0001890 140 0.965
positive regulation of nervous system development GO:0051962 221 0.964
positive regulation of heart growth GO:0060421 18 0.963
negative regulation of protein modification process GO:0031400 163 0.963
Mouse
regulation of insulin receptor signaling pathway GO:0046626 21 0.962
negative regulation of lymphocyte proliferation GO:0050672 45 0.962
Mouse
cardiac endothelial cell differentiation GO:0003348 4 0.962
cellular response to epidermal growth factor stimulus GO:0071364 4 0.961
apoptotic signaling pathway GO:0097190 306 0.960
negative regulation of phosphorus metabolic process GO:0010563 184 0.960
Mouse
heart morphogenesis GO:0003007 178 0.960
Zebrafish
response to organic cyclic compound GO:0014070 198 0.959
negative regulation of translational initiation GO:0045947 4 0.959
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 68 0.959
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.958
embryonic heart tube left right pattern formation GO:0060971 5 0.958
sensory organ morphogenesis GO:0090596 242 0.958
Fly
negative regulation of molecular function GO:0044092 258 0.956
Mouse
carbon catabolite repression of transcription from rna polymerase ii promoter GO:0000437 1 0.956
tyrosine phosphorylation of stat protein GO:0007260 23 0.956
columnar cuboidal epithelial cell differentiation GO:0002065 82 0.954
Fly
epithelial cell proliferation GO:0050673 174 0.954
response to peptide GO:1901652 136 0.954
Human
negative regulation of ras protein signal transduction GO:0046580 18 0.954
negative regulation of phosphorylation GO:0042326 166 0.954
Mouse
germ cell development GO:0007281 185 0.954
Fly
lens development in camera type eye GO:0002088 62 0.954
associative learning GO:0008306 61 0.953
cardiac septum development GO:0003279 59 0.953
positive regulation of cellular amine metabolic process GO:0033240 5 0.953
mesenchymal cell development GO:0014031 93 0.953
telencephalon development GO:0021537 186 0.950
atrial septum primum morphogenesis GO:0003289 3 0.950
endodermal cell fate commitment GO:0001711 12 0.950
regulation of cardioblast differentiation GO:0051890 3 0.949
negative regulation of wnt signaling pathway involved in heart development GO:0003308 4 0.949
oocyte differentiation GO:0009994 35 0.948
cognition GO:0050890 149 0.948
cardiac muscle tissue morphogenesis GO:0055008 44 0.948
outflow tract morphogenesis GO:0003151 53 0.947
mesenchymal cell differentiation GO:0048762 107 0.947
g protein coupled receptor signaling pathway GO:0007186 243 0.946
transcriptional activation by promoter enhancer looping GO:0071733 2 0.945
cellular response to insulin stimulus GO:0032869 78 0.945
Human
blood circulation GO:0008015 195 0.944
septum primum development GO:0003284 4 0.943
peripheral nervous system development GO:0007422 53 0.943
response to growth factor GO:0070848 198 0.943
regulation of intracellular transport GO:0032386 159 0.943
cerebral cortex development GO:0021987 86 0.942
negative regulation of glial cell proliferation GO:0060253 4 0.941
regulation of protein localization GO:0032880 231 0.940
spongiotrophoblast layer development GO:0060712 15 0.940
regulation of cell activation GO:0050865 289 0.939
Mouse
positive regulation of transcription from rna polymerase iii promoter GO:0045945 1 0.939
immune response activating signal transduction GO:0002757 116 0.938
Mouse
regulation of tyrosine phosphorylation of stat protein GO:0042509 20 0.937
response to corticosteroid GO:0031960 20 0.937
lymphocyte differentiation GO:0030098 242 0.936
Mouse
positive regulation of neuron differentiation GO:0045666 141 0.935
cell proliferation involved in outflow tract morphogenesis GO:0061325 4 0.935
neuron projection extension GO:1990138 64 0.935
multicellular organism growth GO:0035264 161 0.934
metanephric glomerular mesangium development GO:0072223 3 0.934
branching morphogenesis of an epithelial tube GO:0048754 159 0.933
regulation of myeloid leukocyte differentiation GO:0002761 58 0.932
atrial cardiac muscle cell differentiation GO:0055011 2 0.932
positive regulation of vasoconstriction GO:0045907 4 0.931
mitotic cell cycle GO:0000278 195 0.931
muscle cell development GO:0055001 133 0.931
response to epidermal growth factor GO:0070849 4 0.929
neuronal action potential GO:0019228 54 0.929
cerebral cortex cell migration GO:0021795 44 0.928
response to steroid hormone GO:0048545 56 0.927
autophagy GO:0006914 45 0.925
cardiac muscle tissue regeneration GO:0061026 1 0.924
trophoblast giant cell differentiation GO:0060707 15 0.922
myeloid leukocyte differentiation GO:0002573 119 0.922
atrial ventricular junction remodeling GO:0003294 2 0.922
cellular response to cytokine stimulus GO:0071345 189 0.921
positive regulation of transcription from rna polymerase ii promoter in response to stress GO:0036003 3 0.921
regulation of nucleocytoplasmic transport GO:0046822 73 0.920
cardiac muscle cell development GO:0055013 39 0.920
regionalization GO:0003002 337 0.920
Fly
negative regulation of cellular amine metabolic process GO:0033239 1 0.918
ovarian follicle development GO:0001541 40 0.918
carbon catabolite regulation of transcription GO:0045990 4 0.918
positive regulation of leukocyte differentiation GO:1902107 86 0.917
mitotic cell cycle process GO:1903047 159 0.917
telencephalon cell migration GO:0022029 55 0.916
cell adhesion GO:0007155 329 0.913
positive regulation of apoptotic signaling pathway GO:2001235 95 0.912
negative regulation of nervous system development GO:0051961 156 0.912
neuron apoptotic process GO:0051402 142 0.911
negative regulation of neurotransmitter transport GO:0051589 7 0.908
embryonic heart tube anterior posterior pattern specification GO:0035054 3 0.907
negative regulation of release of cytochrome c from mitochondria GO:0090201 6 0.906
embryonic hemopoiesis GO:0035162 23 0.905
heart field specification GO:0003128 6 0.905
neural crest cell differentiation GO:0014033 54 0.904
cardiac muscle tissue growth GO:0055017 37 0.904
immune effector process GO:0002252 321 0.903
Mouse
neural crest cell migration GO:0001755 32 0.903
peptide hormone secretion GO:0030072 109 0.902
positive regulation of ras protein signal transduction GO:0046579 13 0.901
cardiac chamber morphogenesis GO:0003206 93 0.901
positive regulation of cardiac muscle tissue growth GO:0055023 15 0.900
intracellular protein transport GO:0006886 204 0.899
insulin receptor signaling pathway GO:0008286 49 0.898
cell differentiation involved in embryonic placenta development GO:0060706 26 0.898
neural crest cell development GO:0014032 48 0.898
cerebral cortex radial glia guided migration GO:0021801 17 0.897
forebrain development GO:0030900 302 0.896
gonad development GO:0008406 141 0.893
heart growth GO:0060419 45 0.892
regulation of muscle cell apoptotic process GO:0010660 17 0.892
nucleocytoplasmic transport GO:0006913 139 0.892
kidney epithelium development GO:0072073 121 0.891
regulation of membrane potential GO:0042391 192 0.890
skeletal muscle cell differentiation GO:0035914 66 0.889
regulation of map kinase activity GO:0043405 120 0.888
mitochondrion organization GO:0007005 134 0.888
regulation of cardiac muscle tissue development GO:0055024 31 0.887
pallium development GO:0021543 120 0.887
protein kinase b signaling GO:0043491 74 0.886
activation of mapkk activity GO:0000186 15 0.885
eye photoreceptor cell differentiation GO:0001754 41 0.884
Fly
negative regulation of transferase activity GO:0051348 85 0.884
Mouse
response to alcohol GO:0097305 48 0.883
negative regulation of kinase activity GO:0033673 81 0.881
Mouse
cellular response to amino acid stimulus GO:0071230 29 0.881
regulation of cardiac muscle cell proliferation GO:0060043 23 0.881
growth plate cartilage chondrocyte development GO:0003431 3 0.880
schwann cell development GO:0014044 22 0.879
cell fate commitment GO:0045165 210 0.879
Fly
regulation of apoptotic process involved in outflow tract morphogenesis GO:1902256 2 0.879
cellular response to glucocorticoid stimulus GO:0071385 13 0.877
regulation of feeding behavior GO:0060259 3 0.876
cardioblast migration GO:0003260 1 0.875
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.871
regulation of blood circulation GO:1903522 93 0.870
central nervous system morphogenesis GO:0021551 2 0.870
positive regulation of cell cycle process GO:0090068 61 0.869
regulation of ras protein signal transduction GO:0046578 114 0.865
cardiac muscle cell proliferation GO:0060038 31 0.864
positive regulation of transcription via serum response element binding GO:0010735 1 0.864
ventricular trabecula myocardium morphogenesis GO:0003222 11 0.863
regulation of hydrolase activity GO:0051336 246 0.863
regulation of epidermal cell differentiation GO:0045604 21 0.862
regulation of mast cell differentiation GO:0060375 3 0.861
positive regulation of axon extension GO:0045773 20 0.860
regulation of stat protein import into nucleus GO:2000364 2 0.860
mammary gland morphogenesis GO:0060443 54 0.860
cytokine production GO:0001816 319 0.857
regulation of anoikis GO:2000209 2 0.857
actin filament organization GO:0007015 113 0.855
cellular response to organonitrogen compound GO:0071417 145 0.855
Human
positive regulation of tyrosine phosphorylation of stat5 protein GO:0042523 6 0.852
nuclear transport GO:0051169 139 0.852
regulation of cardiac cell fate specification GO:2000043 1 0.851
carbohydrate metabolic process GO:0005975 230 0.851
forebrain neuron differentiation GO:0021879 52 0.851
regulation of tyrosine phosphorylation of stat5 protein GO:0042522 8 0.849
second messenger mediated signaling GO:0019932 73 0.848
cellular response to abiotic stimulus GO:0071214 56 0.844
positive regulation of protein modification process GO:0031401 299 0.844
learning GO:0007612 98 0.842
negative regulation of receptor activity GO:2000272 5 0.842
directional locomotion GO:0033058 3 0.842
activation of janus kinase activity GO:0042976 2 0.837
regulation of neuron differentiation GO:0045664 281 0.837
Fly
synapse organization GO:0050808 125 0.836
positive regulation of transcription elongation from rna polymerase ii promoter GO:0032968 2 0.835
circulatory system process GO:0003013 197 0.834
regulation of establishment of protein localization GO:0070201 181 0.834
g1 s transition of mitotic cell cycle GO:0000082 57 0.834
regulation of neuronal synaptic plasticity GO:0048168 30 0.834
actin cytoskeleton organization GO:0030036 220 0.832
mammary gland epithelium development GO:0061180 65 0.832
chromatin organization GO:0006325 206 0.831
establishment of organelle localization GO:0051656 122 0.828
negative regulation of leukocyte differentiation GO:1902106 51 0.827
cerebral cortex radially oriented cell migration GO:0021799 31 0.823
signal transduction in absence of ligand GO:0038034 55 0.822
purine ribonucleotide catabolic process GO:0009154 208 0.822
kidney development GO:0001822 213 0.821
cellular response to peptide GO:1901653 92 0.821
Human
regulation of t cell proliferation GO:0042129 92 0.820
Mouse
regulation of intracellular protein transport GO:0033157 82 0.820
negative regulation of protein metabolic process GO:0051248 282 0.819
Mouse
negative regulation of osteoclast differentiation GO:0045671 12 0.818
axon target recognition GO:0007412 4 0.818
camera type eye development GO:0043010 266 0.817
oocyte construction GO:0007308 2 0.816
negative regulation of phosphate metabolic process GO:0045936 184 0.815
Mouse
negative regulation of apoptotic signaling pathway GO:2001234 104 0.815
endocardial cell differentiation GO:0060956 4 0.814
positive regulation of protein kinase activity GO:0045860 144 0.813
transmission of nerve impulse GO:0019226 76 0.811
cardiac ventricle development GO:0003231 83 0.810
heart valve development GO:0003170 23 0.810
positive regulation of cell migration GO:0030335 109 0.810
neuron neuron synaptic transmission GO:0007270 69 0.810
regulation of protein tyrosine kinase activity GO:0061097 17 0.807
neuron death GO:0070997 154 0.804
positive regulation of cell growth GO:0030307 33 0.803
regulation of peptidyl tyrosine phosphorylation GO:0050730 93 0.801
Mouse
cell aging GO:0007569 35 0.801
multicellular organismal signaling GO:0035637 91 0.799
regulation of cellular catabolic process GO:0031329 242 0.799
protein kinase c activating g protein coupled receptor signaling pathway GO:0007205 4 0.798
av node cell to bundle of his cell communication GO:0086067 2 0.796
regulation of osteoblast differentiation GO:0045667 67 0.796
tor signaling GO:0031929 21 0.795
adaptive immune response GO:0002250 155 0.795
Mouse
regulation of synaptic plasticity GO:0048167 87 0.794
cytoplasmic transport GO:0016482 234 0.794
regulation of cardiac muscle tissue growth GO:0055021 26 0.793
respiratory system development GO:0060541 190 0.792
Fly
negative regulation of cell fate specification GO:0009996 4 0.787
angiogenesis GO:0001525 201 0.786
regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001239 26 0.785
regulation of protein import into nucleus GO:0042306 52 0.784
negative regulation of protein serine threonine kinase activity GO:0071901 49 0.781
Mouse
canonical wnt signaling pathway involved in heart development GO:0061316 3 0.779
erk1 and erk2 cascade GO:0070371 77 0.778
negative regulation of muscle cell apoptotic process GO:0010656 9 0.777
lung development GO:0030324 164 0.775
positive regulation of transcription by glucose GO:0046016 3 0.775
regulation of cell migration GO:0030334 219 0.773
epidermis development GO:0008544 187 0.771
aortic valve morphogenesis GO:0003180 4 0.767
positive regulation of apoptotic process involved in mammary gland involution GO:0060058 4 0.766
embryonic organ morphogenesis GO:0048562 276 0.766
Zebrafish
response to fibroblast growth factor GO:0071774 47 0.765
Fly
chondrocyte hypertrophy GO:0003415 4 0.764
organ regeneration GO:0031100 2 0.763
axonogenesis GO:0007409 274 0.761
negative regulation of cardiac muscle tissue development GO:0055026 8 0.761
ventricular cardiac muscle cell differentiation GO:0055012 17 0.760
monocyte differentiation GO:0030224 9 0.759
regulation of system process GO:0044057 200 0.759
positive regulation of erk1 and erk2 cascade GO:0070374 47 0.758
morphogenesis of a branching epithelium GO:0061138 193 0.758
regulation of smad protein import into nucleus GO:0060390 3 0.758
negative regulation of map kinase activity GO:0043407 34 0.757
Mouse
metanephric nephron tubule formation GO:0072289 4 0.756
regulation of cell cycle process GO:0010564 160 0.756
negative regulation of myeloid leukocyte differentiation GO:0002762 20 0.756
germ line stem cell division GO:0042078 2 0.755
hindbrain radial glia guided cell migration GO:0021932 12 0.751
regulation of cell motility GO:2000145 236 0.750
protein catabolic process GO:0030163 221 0.749
embryonic heart tube development GO:0035050 65 0.749
Zebrafish
cell type specific apoptotic process GO:0097285 268 0.749
mechanoreceptor differentiation GO:0042490 67 0.749
branching involved in mammary gland duct morphogenesis GO:0060444 27 0.747
regulation of epithelial cell migration GO:0010632 35 0.745
multi organism reproductive behavior GO:0044705 29 0.745
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.744
negative regulation of epidermal growth factor receptor signaling pathway GO:0042059 6 0.744
cell fate specification GO:0001708 72 0.742
maternal process involved in female pregnancy GO:0060135 32 0.740
growth plate cartilage development GO:0003417 14 0.738
regulation of heart growth GO:0060420 31 0.737
negative regulation of peptide hormone secretion GO:0090278 16 0.737
cardiac myofibril assembly GO:0055003 12 0.736
action potential GO:0001508 78 0.735
protein targeting GO:0006605 143 0.734
regulation of myoblast differentiation GO:0045661 29 0.732
wnt signaling pathway involved in kidney development GO:0061289 2 0.730
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 61 0.729
positive regulation of programmed cell death GO:0043068 218 0.728
pigment metabolic process GO:0042440 32 0.728
ventricular septum development GO:0003281 42 0.727
alpha beta t cell differentiation GO:0046632 69 0.726
cellular lipid metabolic process GO:0044255 323 0.725
positive regulation of osteoblast proliferation GO:0033690 9 0.724
positive regulation of cell development GO:0010720 237 0.724
negative regulation of cell development GO:0010721 169 0.724
mast cell differentiation GO:0060374 5 0.723
positive regulation of cardiac muscle cell proliferation GO:0060045 15 0.722
protein import into nucleus GO:0006606 95 0.722
prostate gland epithelium morphogenesis GO:0060740 31 0.721
mesonephric tubule development GO:0072164 94 0.721
atrioventricular valve morphogenesis GO:0003181 13 0.721
erythrocyte differentiation GO:0030218 88 0.720
positive regulation of epithelial cell proliferation GO:0050679 68 0.720
digestive tract morphogenesis GO:0048546 147 0.720
Zebrafish
digestive system development GO:0055123 200 0.720
Zebrafish
mammary gland lobule development GO:0061377 22 0.719
cellular response to radiation GO:0071478 28 0.714
glial cell differentiation GO:0010001 131 0.709
cardiac muscle fiber development GO:0048739 4 0.709
astrocyte activation GO:0048143 2 0.708
liver development GO:0001889 66 0.707
negative regulation of mapk cascade GO:0043409 65 0.705
Mouse
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 34 0.704
prostate gland stromal morphogenesis GO:0060741 2 0.703
regulation of defense response GO:0031347 233 0.703
regulation of t cell differentiation in thymus GO:0033081 24 0.702
cardiac conduction system development GO:0003161 12 0.702
regulation of cell migration involved in sprouting angiogenesis GO:0090049 4 0.701
negative regulation of cellular response to insulin stimulus GO:1900077 16 0.699
rhodopsin mediated signaling pathway GO:0016056 4 0.698
negative regulation of immune system process GO:0002683 209 0.696
Mouse
oligodendrocyte differentiation GO:0048709 53 0.694
negative regulation of neuron projection development GO:0010977 50 0.694
positive regulation of lymphocyte differentiation GO:0045621 61 0.693
spermatid differentiation GO:0048515 115 0.693
organonitrogen compound catabolic process GO:1901565 264 0.692
regulation of heart contraction GO:0008016 77 0.692
positive regulation of fibroblast proliferation GO:0048146 20 0.692
cellular response to steroid hormone stimulus GO:0071383 33 0.691
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 45 0.689
regulation of epidermal growth factor activated receptor activity GO:0007176 7 0.687
positive regulation of cell cycle GO:0045787 92 0.684
regulation of transcription from rna polymerase iii promoter GO:0006359 2 0.683
mitral valve development GO:0003174 4 0.679
extracellular matrix dependent thymocyte migration GO:0072680 1 0.676
fused antrum stage GO:0048165 1 0.675
positive regulation of stem cell proliferation GO:2000648 59 0.669
epithelial cell differentiation involved in prostate gland development GO:0060742 13 0.669
mammary gland epithelial cell differentiation GO:0060644 13 0.669
vesicle localization GO:0051648 86 0.668
leukocyte proliferation GO:0070661 172 0.666
Mouse
negative regulation of lymphocyte apoptotic process GO:0070229 24 0.666
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.664
regulation of epidermal growth factor receptor signaling pathway GO:0042058 13 0.664
ameboidal type cell migration GO:0001667 128 0.664
Fly
response to drug GO:0042493 75 0.664
lymphocyte homeostasis GO:0002260 64 0.663
single organism cell adhesion GO:0098602 156 0.660
Mouse
negative regulation of cell activation GO:0050866 111 0.657
Mouse
eye photoreceptor cell development GO:0042462 31 0.657
Fly
t cell differentiation in thymus GO:0033077 77 0.655
positive regulation of intracellular protein transport GO:0090316 42 0.655
glycosyl compound catabolic process GO:1901658 206 0.654
lateral mesoderm morphogenesis GO:0048369 3 0.654
lung induction GO:0060492 3 0.654
cellular response to acid chemical GO:0071229 68 0.652
regulation of hippo signaling GO:0035330 1 0.652
positive regulation of transcription from rna polymerase ii promoter by glucose GO:0000432 3 0.651
cellular nitrogen compound catabolic process GO:0044270 280 0.649
positive regulation of auditory receptor cell differentiation GO:0045609 1 0.649
microtubule cytoskeleton organization GO:0000226 157 0.649
positive regulation of nucleocytoplasmic transport GO:0046824 30 0.648
regeneration GO:0031099 38 0.647
negative regulation of endothelial cell proliferation GO:0001937 8 0.646
protein autophosphorylation GO:0046777 61 0.643
muscle cell apoptotic process GO:0010657 18 0.642
regulation of gtp catabolic process GO:0033124 113 0.641
segmentation GO:0035282 93 0.638
Fly
negative regulation of transcription from rna polymerase ii promoter in response to stress GO:0097201 1 0.637
regulation of neural precursor cell proliferation GO:2000177 70 0.636
prostate glandular acinus development GO:0060525 12 0.636
regulation of cellular component biogenesis GO:0044087 181 0.636
positive regulation of thymocyte migration GO:2000412 2 0.636
regulation of activation of jak2 kinase activity GO:0010534 1 0.635
regulation of filopodium assembly GO:0051489 13 0.635
t cell differentiation GO:0030217 174 0.634
regulation of cell adhesion GO:0030155 154 0.634
regulation of cytoplasmic transport GO:1903649 112 0.633
positive regulation of smooth muscle cell migration GO:0014911 4 0.632
positive regulation of t cell differentiation GO:0045582 52 0.632
cellular response to inorganic substance GO:0071241 37 0.631
negative regulation of mesodermal cell fate specification GO:0042662 3 0.630
regulation of skeletal muscle fiber development GO:0048742 36 0.629
regulation of osteoclast differentiation GO:0045670 36 0.627
respiratory tube development GO:0030323 167 0.626
positive regulation of lipid kinase activity GO:0090218 11 0.625
lung cell differentiation GO:0060479 30 0.624
ventricular cardiac myofibril assembly GO:0055005 3 0.622
negative regulation of endothelial cell differentiation GO:0045602 2 0.621
response to acid chemical GO:0001101 111 0.620

Ptpn11 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
heart disease DOID:114 0 0.988
disease of anatomical entity DOID:7 0 0.988
cardiovascular system disease DOID:1287 0 0.988
musculoskeletal system disease DOID:17 0 0.803
cancer DOID:162 0 0.648
Human
disease of cellular proliferation DOID:14566 0 0.648
Human
organ system cancer DOID:0050686 0 0.648
Human