Mus musculus

77 known processes

Ptpn22

protein tyrosine phosphatase, non-receptor type 22 (lymphoid)

(Aliases: Ptpn8,PEP,70zpep)

Ptpn22 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cation transport GO:0006812 399 0.764
amine metabolic process GO:0009308 45 0.760
positive regulation of cellular amine metabolic process GO:0033240 5 0.746
t cell proliferation GO:0042098 120 0.723
release of cytochrome c from mitochondria GO:0001836 23 0.722
defense response to other organism GO:0098542 197 0.718
immune response activating signal transduction GO:0002757 116 0.704
immune effector process GO:0002252 321 0.698
dephosphorylation GO:0016311 129 0.661
cell activation involved in immune response GO:0002263 126 0.623
regulation of homotypic cell cell adhesion GO:0034110 13 0.603
regulation of alpha beta t cell differentiation GO:0046637 35 0.596
regulation of lymphocyte activation GO:0051249 240 0.594
immune response regulating signaling pathway GO:0002764 125 0.594
leukocyte mediated immunity GO:0002443 174 0.592
t cell differentiation GO:0030217 174 0.589
positive regulation of gamma delta t cell differentiation GO:0045588 6 0.580
single organism cell adhesion GO:0098602 156 0.573
myeloid leukocyte activation GO:0002274 83 0.551
positive regulation of alpha beta t cell differentiation GO:0046638 28 0.548
t helper 2 cell cytokine production GO:0035745 4 0.533
cellular nitrogen compound catabolic process GO:0044270 280 0.526
interleukin 2 production GO:0032623 33 0.521
negative regulation of cellular amine metabolic process GO:0033239 1 0.517
ras protein signal transduction GO:0007265 77 0.513
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.512
positive regulation of innate immune response GO:0045089 80 0.511
gtp catabolic process GO:0006184 143 0.511
cytoplasmic transport GO:0016482 234 0.510
t cell differentiation in thymus GO:0033077 77 0.505
regulation of leukocyte proliferation GO:0070663 121 0.491
Human
alpha beta t cell differentiation GO:0046632 69 0.481
guanosine containing compound catabolic process GO:1901069 144 0.479
b cell receptor signaling pathway GO:0050853 20 0.469
positive t cell selection GO:0043368 23 0.468
negative regulation of protein metabolic process GO:0051248 282 0.456
positive regulation of calcium mediated signaling GO:0050850 15 0.446
negative regulation of t cell mediated cytotoxicity GO:0001915 3 0.442
regulation of cytokine biosynthetic process GO:0042035 59 0.437
regulation of alpha beta t cell activation GO:0046634 53 0.433
regulation of t cell proliferation GO:0042129 92 0.430
cellular amine metabolic process GO:0044106 44 0.430
release of sequestered calcium ion into cytosol GO:0051209 42 0.429
regulation of t cell activation GO:0050863 170 0.421
lipid biosynthetic process GO:0008610 179 0.418
leukocyte cell cell adhesion GO:0007159 14 0.410
regulation of leukocyte differentiation GO:1902105 159 0.409
regulation of mast cell activation GO:0033003 21 0.406
positive regulation of cytokine biosynthetic process GO:0042108 40 0.406
cytokine metabolic process GO:0042107 71 0.405
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.404
production of molecular mediator of immune response GO:0002440 103 0.399
ribonucleoside triphosphate metabolic process GO:0009199 220 0.399
regulation of t cell differentiation GO:0045580 83 0.396
organic cyclic compound catabolic process GO:1901361 295 0.395
b cell proliferation GO:0042100 53 0.394
leukocyte differentiation GO:0002521 342 0.394
negative regulation of cellular component organization GO:0051129 194 0.384
positive regulation of alpha beta t cell activation GO:0046635 39 0.377
positive regulation of interleukin 10 secretion GO:2001181 1 0.377
positive regulation of cell activation GO:0050867 158 0.375
cellular amino acid metabolic process GO:0006520 103 0.372
regulation of hydrolase activity GO:0051336 246 0.369
ribonucleoside triphosphate catabolic process GO:0009203 199 0.369
cytokine production GO:0001816 319 0.363
positive regulation of t cell activation GO:0050870 101 0.363
adaptive immune response GO:0002250 155 0.358
positive regulation of t cell differentiation GO:0045582 52 0.356
lymphocyte activation involved in immune response GO:0002285 93 0.356
regulation of cellular ketone metabolic process GO:0010565 66 0.356
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 87 0.349
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.339
positive regulation of gtp catabolic process GO:0033126 85 0.337
innate immune response activating signal transduction GO:0002758 50 0.334
rho protein signal transduction GO:0007266 32 0.334
lymphocyte differentiation GO:0030098 242 0.334
nucleoside catabolic process GO:0009164 206 0.333
cytokine biosynthetic process GO:0042089 68 0.327
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.324
protein maturation GO:0051604 176 0.324
establishment of protein localization to organelle GO:0072594 118 0.322
ribonucleoside catabolic process GO:0042454 206 0.321
regulation of lymphocyte mediated immunity GO:0002706 84 0.321
small gtpase mediated signal transduction GO:0007264 97 0.317
regulation of alpha beta t cell proliferation GO:0046640 18 0.312
regulation of ras protein signal transduction GO:0046578 114 0.312
positive regulation of t helper 2 cell cytokine production GO:2000553 3 0.310
regulation of cellular amino acid metabolic process GO:0006521 5 0.310
cd4 positive alpha beta t cell cytokine production GO:0035743 4 0.307
guanosine containing compound metabolic process GO:1901068 144 0.303
defense response to bacterium GO:0042742 119 0.297
alpha beta t cell differentiation involved in immune response GO:0002293 30 0.295
response to granulocyte macrophage colony stimulating factor GO:0097012 3 0.294
purine ribonucleotide metabolic process GO:0009150 290 0.291
actin filament organization GO:0007015 113 0.281
single organismal cell cell adhesion GO:0016337 131 0.281
reactive oxygen species metabolic process GO:0072593 84 0.279
cell adhesion GO:0007155 329 0.278
regulation of insulin receptor signaling pathway GO:0046626 21 0.277
negative thymic t cell selection GO:0045060 12 0.275
glycosyl compound catabolic process GO:1901658 206 0.274
nucleoside phosphate metabolic process GO:0006753 338 0.272
nitrogen compound transport GO:0071705 271 0.270
purine nucleotide catabolic process GO:0006195 211 0.270
organonitrogen compound catabolic process GO:1901565 264 0.268
t cell mediated immunity GO:0002456 50 0.267
homeostasis of number of cells GO:0048872 210 0.264
regulation of gtp catabolic process GO:0033124 113 0.264
cellular ketone metabolic process GO:0042180 84 0.263
nucleocytoplasmic transport GO:0006913 139 0.263
positive regulation of t cell mediated immunity GO:0002711 24 0.261
positive regulation of granulocyte macrophage colony stimulating factor biosynthetic process GO:0045425 2 0.259
organelle fusion GO:0048284 28 0.259
female gamete generation GO:0007292 74 0.252
purine ribonucleotide catabolic process GO:0009154 208 0.252
purine containing compound metabolic process GO:0072521 311 0.248
ral protein signal transduction GO:0032484 2 0.245
plasma membrane organization GO:0007009 90 0.244
regulation of leukocyte mediated immunity GO:0002703 104 0.243
cellular lipid metabolic process GO:0044255 323 0.242
regulation of t helper 2 cell cytokine production GO:2000551 3 0.241
negative regulation of cellular protein metabolic process GO:0032269 247 0.239
regulation of rho protein signal transduction GO:0035023 71 0.239
interleukin 10 secretion GO:0072608 4 0.237
lymphocyte mediated immunity GO:0002449 139 0.234
membrane tubulation GO:0097320 4 0.233
leukocyte activation involved in immune response GO:0002366 126 0.232
protein localization to membrane GO:0072657 108 0.231
positive regulation of cytokine production GO:0001819 174 0.230
regulation of purine nucleotide catabolic process GO:0033121 122 0.228
nucleoside metabolic process GO:0009116 246 0.225
regulation of nucleotide catabolic process GO:0030811 122 0.225
cd4 positive alpha beta t cell differentiation involved in immune response GO:0002294 28 0.224
establishment of organelle localization GO:0051656 122 0.221
positive regulation of cell death GO:0010942 224 0.220
purine nucleoside catabolic process GO:0006152 205 0.220
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 62 0.218
positive regulation of defense response GO:0031349 124 0.213
positive regulation of programmed cell death GO:0043068 218 0.211
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.211
protein processing GO:0016485 163 0.210
purine nucleoside triphosphate catabolic process GO:0009146 203 0.209
organophosphate catabolic process GO:0046434 232 0.207
t cell activation involved in immune response GO:0002286 43 0.205
nucleotide metabolic process GO:0009117 332 0.205
positive regulation of gtpase activity GO:0043547 85 0.205
positive regulation of leukocyte proliferation GO:0070665 73 0.205
c4 dicarboxylate transport GO:0015740 3 0.204
cd4 positive alpha beta t cell activation GO:0035710 45 0.203
ossification GO:0001503 216 0.203
protein import into nucleus GO:0006606 95 0.202
positive regulation of hydrolase activity GO:0051345 148 0.200
vesicle fusion GO:0006906 16 0.200
positive thymic t cell selection GO:0045059 13 0.198
regulation of cellular amine metabolic process GO:0033238 20 0.197
positive regulation of intracellular transport GO:0032388 70 0.197
inflammatory response GO:0006954 244 0.196
t helper cell differentiation GO:0042093 28 0.196
regulation of cell adhesion GO:0030155 154 0.195
labyrinthine layer blood vessel development GO:0060716 21 0.193
positive regulation of lymphocyte differentiation GO:0045621 61 0.193
regulation of response to wounding GO:1903034 189 0.191
positive regulation of t cell cytokine production GO:0002726 5 0.191
negative regulation of adaptive immune response GO:0002820 25 0.191
cd4 positive alpha beta t cell differentiation GO:0043367 41 0.190
regulation of granulocyte macrophage colony stimulating factor biosynthetic process GO:0045423 2 0.189
negative regulation of peptidyl tyrosine phosphorylation GO:0050732 17 0.189
glycosyl compound metabolic process GO:1901657 246 0.188
purine containing compound catabolic process GO:0072523 213 0.187
positive regulation of adaptive immune response GO:0002821 61 0.187
microtubule based process GO:0007017 236 0.186
interleukin 2 biosynthetic process GO:0042094 15 0.186
regulation of protein localization GO:0032880 231 0.185
vesicle organization GO:0016050 60 0.184
regulation of release of cytochrome c from mitochondria GO:0090199 11 0.183
positive regulation of rho gtpase activity GO:0032321 41 0.182
regulation of lymphocyte differentiation GO:0045619 107 0.181
nucleoside phosphate catabolic process GO:1901292 222 0.181
response to organic cyclic compound GO:0014070 198 0.181
purine nucleotide metabolic process GO:0006163 302 0.180
t cell differentiation involved in immune response GO:0002292 30 0.179
regulation of actin polymerization or depolymerization GO:0008064 45 0.178
negative regulation of phosphorylation GO:0042326 166 0.177
regulation of mitochondrion organization GO:0010821 27 0.176
regulation of vesicle mediated transport GO:0060627 139 0.175
negative regulation of protein phosphorylation GO:0001933 126 0.173
positive regulation of response to wounding GO:1903036 66 0.172
negative regulation of phosphate metabolic process GO:0045936 184 0.172
peptidyl amino acid modification GO:0018193 336 0.171
regulation of protein maturation GO:1903317 96 0.171
regulation of interleukin 2 production GO:0032663 28 0.170
single organism nuclear import GO:1902593 95 0.169
leukocyte proliferation GO:0070661 172 0.168
Human
negative regulation of insulin receptor signaling pathway GO:0046627 14 0.168
carboxylic acid transport GO:0046942 100 0.168
negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 23 0.168
interleukin 4 production GO:0032633 24 0.167
purine nucleoside metabolic process GO:0042278 241 0.164
regulation of ral gtpase activity GO:0032315 4 0.164
positive regulation of lymphocyte proliferation GO:0050671 70 0.163
ribose phosphate metabolic process GO:0019693 291 0.162
lymphocyte proliferation GO:0046651 164 0.160
Human
b cell apoptotic process GO:0001783 19 0.160
carbohydrate derivative catabolic process GO:1901136 231 0.160
negative regulation of b cell proliferation GO:0030889 13 0.158
nucleotide catabolic process GO:0009166 217 0.158
negative regulation of hydrolase activity GO:0051346 71 0.157
response to oxidative stress GO:0006979 123 0.153
positive regulation of nucleotide catabolic process GO:0030813 88 0.153
toll like receptor signaling pathway GO:0002224 38 0.152
immunoglobulin production GO:0002377 73 0.151
regulation of lymphocyte proliferation GO:0050670 117 0.151
Human
positive regulation of immune effector process GO:0002699 107 0.150
positive regulation of lymphocyte mediated immunity GO:0002708 62 0.150
regulation of blood coagulation GO:0030193 28 0.149
heterocycle catabolic process GO:0046700 280 0.148
regulation of cd4 positive alpha beta t cell activation GO:2000514 24 0.147
g protein coupled receptor signaling pathway GO:0007186 243 0.147
ceramide biosynthetic process GO:0046513 20 0.147
second messenger mediated signaling GO:0019932 73 0.147
establishment or maintenance of microtubule cytoskeleton polarity GO:0030951 1 0.146
organelle localization GO:0051640 179 0.145
b cell activation GO:0042113 161 0.145
positive regulation of gamma delta t cell activation GO:0046645 6 0.144
myeloid cell homeostasis GO:0002262 114 0.143
regulation of cysteine type endopeptidase activity GO:2000116 65 0.142
b cell differentiation GO:0030183 78 0.141
alpha beta t cell activation GO:0046631 91 0.140
regulation of actin cytoskeleton organization GO:0032956 84 0.138
activation of immune response GO:0002253 138 0.138
exocytosis GO:0006887 121 0.137
regulation of ras gtpase activity GO:0032318 88 0.136
purine nucleoside triphosphate metabolic process GO:0009144 226 0.136
thymic t cell selection GO:0045061 22 0.136
regulation of interferon gamma production GO:0032649 57 0.136
labyrinthine layer development GO:0060711 49 0.136
peptidyl serine phosphorylation GO:0018105 74 0.134
positive regulation of interleukin 5 secretion GO:2000664 1 0.134
granulocyte activation GO:0036230 10 0.132
protein import GO:0017038 101 0.131
regulation of cell activation GO:0050865 289 0.130
natural killer cell activation GO:0030101 44 0.130
Human
cellular response to cytokine stimulus GO:0071345 189 0.130
gtp metabolic process GO:0046039 144 0.129
regulation of b cell proliferation GO:0030888 39 0.128
positive regulation of kinase activity GO:0033674 155 0.127
positive regulation of lymphocyte activation GO:0051251 140 0.127
regulation of vesicle fusion GO:0031338 6 0.127
nucleoside triphosphate catabolic process GO:0009143 205 0.126
regulation of defense response GO:0031347 233 0.126
regulation of superoxide metabolic process GO:0090322 8 0.125
regulation of intracellular protein transport GO:0033157 82 0.124
negative regulation of protein maturation GO:1903318 79 0.124
regulation of establishment of protein localization GO:0070201 181 0.124
purine ribonucleoside metabolic process GO:0046128 241 0.124
regulation of secretion GO:0051046 274 0.124
intracellular protein transport GO:0006886 204 0.123
sphingolipid catabolic process GO:0030149 7 0.122
nucleoside triphosphate metabolic process GO:0009141 230 0.122
positive regulation of t cell proliferation GO:0042102 52 0.121
regulation of ion transport GO:0043269 215 0.120
response to peptide GO:1901652 136 0.120
apoptotic mitochondrial changes GO:0008637 48 0.119
negative regulation of phosphorus metabolic process GO:0010563 184 0.119
b cell homeostasis GO:0001782 34 0.119
interleukin 10 production GO:0032613 23 0.118
membrane fusion GO:0061025 38 0.118
t cell selection GO:0045058 34 0.117
membrane organization GO:0061024 245 0.117
regulation of secretion by cell GO:1903530 249 0.117
mast cell mediated immunity GO:0002448 20 0.117
positive regulation of ras gtpase activity GO:0032320 65 0.116
regulation of hemostasis GO:1900046 28 0.114
regulation of b cell differentiation GO:0045577 23 0.114
regulation of kinase activity GO:0043549 249 0.114
regulation of interleukin 2 biosynthetic process GO:0045076 13 0.112
sphingolipid metabolic process GO:0006665 45 0.110
t cell activation GO:0042110 289 0.110
regulation of interleukin 10 production GO:0032653 21 0.109
regulation of adaptive immune response GO:0002819 90 0.109
extrinsic apoptotic signaling pathway GO:0097191 126 0.109
ribonucleoside metabolic process GO:0009119 245 0.108
nuclear import GO:0051170 95 0.108
ribonucleotide metabolic process GO:0009259 291 0.108
glial cell development GO:0021782 54 0.108
purine ribonucleoside catabolic process GO:0046130 205 0.108
oocyte differentiation GO:0009994 35 0.107
positive regulation of apoptotic signaling pathway GO:2001235 95 0.107
antigen receptor mediated signaling pathway GO:0050851 64 0.107
protein secretion GO:0009306 111 0.106
vesicle localization GO:0051648 86 0.106
positive regulation of cytokine secretion GO:0050715 41 0.106
insulin receptor signaling pathway GO:0008286 49 0.105
peptidyl serine modification GO:0018209 83 0.105
positive regulation of t helper 2 cell activation GO:2000570 2 0.105
granulocyte chemotaxis GO:0071621 39 0.104
negative regulation of immune system process GO:0002683 209 0.104
ceramide metabolic process GO:0006672 31 0.103
regulation of cellular response to stress GO:0080135 159 0.101
positive regulation of leukocyte mediated immunity GO:0002705 70 0.100
positive regulation of interleukin 2 biosynthetic process GO:0045086 8 0.097
protein autophosphorylation GO:0046777 61 0.097
positive regulation of nucleoside metabolic process GO:0045979 91 0.097
response to inorganic substance GO:0010035 96 0.096
developmental maturation GO:0021700 193 0.096
nucleobase containing small molecule metabolic process GO:0055086 352 0.096
regulation of interleukin 10 secretion GO:2001179 4 0.096
positive regulation of interleukin 13 secretion GO:2000667 1 0.095
mitochondrion organization GO:0007005 134 0.095
regulation of purine nucleotide metabolic process GO:1900542 169 0.094
endocytosis GO:0006897 168 0.093
positive regulation of cellular catabolic process GO:0031331 148 0.092
activation of jun kinase activity GO:0007257 15 0.092
regulation of ral protein signal transduction GO:0032485 4 0.092
calcium mediated signaling GO:0019722 46 0.092
interleukin 5 secretion GO:0072603 2 0.090
organic anion transport GO:0015711 137 0.090
regulation of intracellular transport GO:0032386 159 0.090
regulation of nucleoside metabolic process GO:0009118 130 0.089
symbiosis encompassing mutualism through parasitism GO:0044403 83 0.089
positive regulation of protein modification process GO:0031401 299 0.086
regulation of transferase activity GO:0051338 263 0.086
positive regulation of purine nucleotide catabolic process GO:0033123 88 0.086
immune response activating cell surface receptor signaling pathway GO:0002429 72 0.086
regulation of cell migration GO:0030334 219 0.086
sphingolipid biosynthetic process GO:0030148 26 0.085
anion transport GO:0006820 177 0.085
regulation of rho gtpase activity GO:0032319 58 0.085
membrane lipid biosynthetic process GO:0046467 32 0.085
peptidyl threonine modification GO:0018210 31 0.085
endomembrane system organization GO:0010256 147 0.084
regulation of organelle organization GO:0033043 289 0.084
interaction with host GO:0051701 22 0.084
positive regulation of b cell differentiation GO:0045579 13 0.083
regulation of phospholipid catabolic process GO:0060696 2 0.083
positive regulation of secretion by cell GO:1903532 114 0.082
innate immune response GO:0045087 157 0.082
cell type specific apoptotic process GO:0097285 268 0.082
myeloid leukocyte migration GO:0097529 57 0.082
immunoglobulin mediated immune response GO:0016064 69 0.081
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.081
amide transport GO:0042886 138 0.081
marginal zone b cell differentiation GO:0002315 2 0.080
placenta development GO:0001890 140 0.080
cellular response to growth factor stimulus GO:0071363 197 0.080
apoptotic signaling pathway GO:0097190 306 0.079
granulocyte macrophage colony stimulating factor production GO:0032604 3 0.079
regulation of interleukin 4 production GO:0032673 18 0.079
activation of ras gtpase activity GO:0032856 11 0.078
regulation of peptidyl tyrosine phosphorylation GO:0050730 93 0.078
immune complex clearance GO:0002434 2 0.078
calcium ion transport GO:0006816 159 0.077
aromatic compound catabolic process GO:0019439 286 0.077
myeloid cell activation involved in immune response GO:0002275 34 0.076
regulation of cytokine production involved in immune response GO:0002718 26 0.076
regulation of reactive oxygen species metabolic process GO:2000377 40 0.075
positive regulation of leukocyte differentiation GO:1902107 86 0.075
regulation of protein kinase activity GO:0045859 232 0.075
sequestering of calcium ion GO:0051208 18 0.075
regulation of t cell mediated immunity GO:0002709 34 0.075
neutrophil chemotaxis GO:0030593 36 0.074
regulation of granulocyte macrophage colony stimulating factor production GO:0032645 3 0.074
granulocyte migration GO:0097530 43 0.073
granulocyte macrophage colony stimulating factor biosynthetic process GO:0042253 2 0.073
protein localization to organelle GO:0033365 185 0.073
microtubule cytoskeleton organization GO:0000226 157 0.072
regulation of metal ion transport GO:0010959 106 0.072
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.072
positive regulation of killing of cells of other organism GO:0051712 3 0.071
regulation of innate immune response GO:0045088 91 0.071
negative regulation of cell adhesion GO:0007162 45 0.070
regulation of cd4 positive alpha beta t cell differentiation GO:0043370 21 0.070
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.070
membrane lipid metabolic process GO:0006643 53 0.069
cellular response to molecule of fungal origin GO:0071226 2 0.069
inorganic ion transmembrane transport GO:0098660 234 0.069
regulation of interleukin 5 secretion GO:2000662 2 0.069
phospholipid metabolic process GO:0006644 87 0.068
regulation of apoptotic signaling pathway GO:2001233 197 0.068
muscle cell differentiation GO:0042692 261 0.068
response to endoplasmic reticulum stress GO:0034976 53 0.068
response to drug GO:0042493 75 0.067
homotypic cell cell adhesion GO:0034109 28 0.067
regulation of gamma delta t cell differentiation GO:0045586 9 0.067
intracellular mrna localization GO:0008298 4 0.067
regulation of b cell activation GO:0050864 81 0.067
generation of precursor metabolites and energy GO:0006091 103 0.067
b cell mediated immunity GO:0019724 71 0.066
cellular response to molecule of bacterial origin GO:0071219 83 0.066
monocarboxylic acid biosynthetic process GO:0072330 61 0.066
negative regulation of intracellular signal transduction GO:1902532 167 0.066
regulation of mapk cascade GO:0043408 248 0.066
establishment or maintenance of cytoskeleton polarity GO:0030952 2 0.065
i kappab kinase nf kappab signaling GO:0007249 85 0.065
interspecies interaction between organisms GO:0044419 83 0.065
positive regulation of homeostatic process GO:0032846 64 0.065
neuronal action potential GO:0019228 54 0.064
positive regulation of vesicle fusion GO:0031340 2 0.064
regulation of peptidase activity GO:0052547 96 0.064
regulation of cytoskeleton organization GO:0051493 122 0.064
peptidyl tyrosine modification GO:0018212 145 0.064
actin filament polymerization GO:0030041 44 0.063
divalent metal ion transport GO:0070838 172 0.063
humoral immune response GO:0006959 57 0.063
regulation of neutrophil differentiation GO:0045658 2 0.063
alpha beta t cell activation involved in immune response GO:0002287 31 0.063
positive regulation of interleukin 5 production GO:0032754 5 0.062
regulation of cell shape GO:0008360 39 0.062
glycogen cell differentiation involved in embryonic placenta development GO:0060709 1 0.062
response to ethanol GO:0045471 18 0.061
myeloid leukocyte mediated immunity GO:0002444 42 0.061
superoxide metabolic process GO:0006801 27 0.061
neutrophil activation GO:0042119 9 0.061
negative regulation of b cell mediated immunity GO:0002713 7 0.061
oocyte construction GO:0007308 2 0.061
regulation of cellular component size GO:0032535 121 0.061
regulation of proteolysis GO:0030162 164 0.060
positive regulation of interleukin 10 production GO:0032733 12 0.059
inositol lipid mediated signaling GO:0048017 41 0.059
regulation of cellular component biogenesis GO:0044087 181 0.059
regulation of exocytosis GO:0017157 61 0.059
interleukin 3 production GO:0032632 3 0.058
glucose metabolic process GO:0006006 92 0.058
t helper 2 cell activation GO:0035712 2 0.058
positive regulation of type 2 immune response GO:0002830 9 0.057
regulation of mast cell degranulation GO:0043304 16 0.057
negative regulation of protein processing GO:0010955 79 0.057
sensory organ morphogenesis GO:0090596 242 0.057
tissue homeostasis GO:0001894 115 0.057
positive regulation of protein phosphorylation GO:0001934 242 0.057
regulation of interleukin 13 secretion GO:2000665 2 0.057
mammary gland epithelium development GO:0061180 65 0.057
negative regulation of leukocyte mediated immunity GO:0002704 29 0.057
regulation of wound healing GO:0061041 40 0.056
extracellular structure organization GO:0043062 148 0.056
regulation of cytokine secretion GO:0050707 61 0.056
autophagy GO:0006914 45 0.056
regulation of body fluid levels GO:0050878 162 0.056
regulation of sphingolipid biosynthetic process GO:0090153 1 0.055
cellular response to nutrient levels GO:0031669 64 0.055
regulation of protein transport GO:0051223 163 0.055
regulation of protein homooligomerization GO:0032462 3 0.054
hematopoietic progenitor cell differentiation GO:0002244 143 0.054
cellular biogenic amine metabolic process GO:0006576 28 0.054
regulation of coagulation GO:0050818 31 0.053
protein targeting GO:0006605 143 0.053
organic hydroxy compound metabolic process GO:1901615 203 0.053
synaptic transmission GO:0007268 329 0.053
negative regulation of cell adhesion involved in substrate bound cell migration GO:0006933 3 0.052
negative regulation of protein modification process GO:0031400 163 0.051
positive regulation of proteolysis GO:0045862 85 0.051
hexose metabolic process GO:0019318 98 0.051
regulation of cell killing GO:0031341 40 0.051
organic acid biosynthetic process GO:0016053 86 0.051
lateral inhibition GO:0046331 1 0.051
coagulation GO:0050817 78 0.050
germ cell development GO:0007281 185 0.050
regulation of protein autophosphorylation GO:0031952 8 0.050
response to reactive oxygen species GO:0000302 56 0.050
positive regulation of protein targeting to membrane GO:0090314 7 0.050
regulation of endopeptidase activity GO:0052548 89 0.050
negative regulation of endopeptidase activity GO:0010951 44 0.049
positive regulation of ral gtpase activity GO:0032852 4 0.049
positive regulation of protein kinase activity GO:0045860 144 0.049
regulation of cell cycle GO:0051726 281 0.048
myeloid cell differentiation GO:0030099 233 0.048
regulation of multi organism process GO:0043900 111 0.048
oocyte axis specification GO:0007309 2 0.048
negative regulation of endocytosis GO:0045806 12 0.048
leukocyte apoptotic process GO:0071887 71 0.048
cellular response to organonitrogen compound GO:0071417 145 0.048
oocyte anterior posterior axis specification GO:0007314 2 0.047
negative regulation of peptidase activity GO:0010466 46 0.047
carboxylic acid biosynthetic process GO:0046394 86 0.047
cellular amide metabolic process GO:0043603 58 0.047
positive regulation of b cell activation GO:0050871 49 0.047
positive regulation of organelle organization GO:0010638 128 0.046
myotube differentiation GO:0014902 105 0.046
positive regulation of alpha beta t cell proliferation GO:0046641 12 0.046
mapk cascade GO:0000165 281 0.046
leukotriene biosynthetic process GO:0019370 5 0.046
eye photoreceptor cell differentiation GO:0001754 41 0.045
blood coagulation GO:0007596 76 0.045
negative regulation of release of cytochrome c from mitochondria GO:0090201 6 0.045
lipid transport GO:0006869 98 0.045
leukocyte migration GO:0050900 124 0.045

Ptpn22 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
immune system disease DOID:2914 0 0.921
Human
disease of anatomical entity DOID:7 0 0.921
Human
musculoskeletal system disease DOID:17 0 0.253
Human
hematopoietic system disease DOID:74 0 0.199
primary immunodeficiency disease DOID:612 0 0.124
blood protein disease DOID:620 0 0.124
agammaglobulinemia DOID:2583 0 0.124
common variable immunodeficiency DOID:12177 0 0.124
b cell deficiency DOID:2115 0 0.124
hypersensitivity reaction disease DOID:0060056 0 0.094
Human
lupus erythematosus DOID:8857 0 0.080
Human
hypersensitivity reaction type ii disease DOID:417 0 0.080
Human
connective tissue disease DOID:65 0 0.073
Human