Mus musculus

396 known processes

Ptprc

protein tyrosine phosphatase, receptor type, C

(Aliases: loc,Cd45,CD45R,T200,Lyt-4,B220,Ly-5)

Ptprc biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
positive regulation of gamma delta t cell differentiation GO:0045588 6 1.000
negative regulation of adaptive immune response GO:0002820 25 1.000
regulation of mast cell activation GO:0033003 21 0.999
Mouse
regulation of antigen receptor mediated signaling pathway GO:0050854 29 0.998
t cell receptor signaling pathway GO:0050852 46 0.998
Human
immune response activating cell surface receptor signaling pathway GO:0002429 72 0.996
negative thymic t cell selection GO:0045060 12 0.995
pattern recognition receptor signaling pathway GO:0002221 47 0.995
positive regulation of type iii hypersensitivity GO:0001805 3 0.995
activation of immune response GO:0002253 138 0.994
regulation of toll like receptor 2 signaling pathway GO:0034135 3 0.994
regulation of cell activation GO:0050865 289 0.990
cell activation involved in immune response GO:0002263 126 0.984
antigen receptor mediated signaling pathway GO:0050851 64 0.984
defense response to other organism GO:0098542 197 0.983
negative regulation of inflammatory response to antigenic stimulus GO:0002862 10 0.981
immune response regulating signaling pathway GO:0002764 125 0.980
regulation of type iia hypersensitivity GO:0001796 4 0.978
t cell activation GO:0042110 289 0.976
mast cell activation GO:0045576 27 0.973
Mouse
adaptive immune response GO:0002250 155 0.972
immune response regulating cell surface receptor signaling pathway GO:0002768 80 0.966
positive regulation of dendritic cell apoptotic process GO:2000670 3 0.965
dephosphorylation GO:0016311 129 0.963
positive regulation of type ii hypersensitivity GO:0002894 4 0.963
amine metabolic process GO:0009308 45 0.962
leukocyte activation involved in immune response GO:0002366 126 0.962
cellular amine metabolic process GO:0044106 44 0.960
lymphocyte differentiation GO:0030098 242 0.959
positive regulation of cellular amine metabolic process GO:0033240 5 0.959
tyrosine phosphorylation of stat5 protein GO:0042506 9 0.958
cd4 positive cd25 positive alpha beta regulatory t cell differentiation GO:0002361 4 0.958
positive regulation of lymphocyte activation GO:0051251 140 0.953
immune response inhibiting signal transduction GO:0002765 4 0.953
positive regulation of mast cell activation involved in immune response GO:0033008 10 0.951
regulation of lymphocyte activation GO:0051249 240 0.951
fc receptor mediated stimulatory signaling pathway GO:0002431 4 0.951
antigen processing and presentation of peptide antigen via mhc class i GO:0002474 9 0.950
negative regulation of leukocyte proliferation GO:0070664 46 0.948
cellular response to molecule of bacterial origin GO:0071219 83 0.947
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.947
blood coagulation GO:0007596 76 0.946
immune response activating signal transduction GO:0002757 116 0.940
regulation of b cell proliferation GO:0030888 39 0.935
myeloid cell activation involved in immune response GO:0002275 34 0.934
positive regulation of regulatory t cell differentiation GO:0045591 4 0.932
positive regulation of leukocyte degranulation GO:0043302 10 0.931
positive regulation of defense response GO:0031349 124 0.931
myeloid leukocyte mediated immunity GO:0002444 42 0.930
integrin mediated signaling pathway GO:0007229 27 0.930
regulation of type ii hypersensitivity GO:0002892 4 0.930
immune effector process GO:0002252 321 0.929
fc epsilon receptor signaling pathway GO:0038095 3 0.925
myeloid leukocyte migration GO:0097529 57 0.925
regulation of leukocyte apoptotic process GO:2000106 56 0.924
regulation of cellular amino acid metabolic process GO:0006521 5 0.922
t cell differentiation in thymus GO:0033077 77 0.922
regulation of tumor necrosis factor production GO:0032680 49 0.919
negative regulation of b cell proliferation GO:0030889 13 0.914
immune response inhibiting cell surface receptor signaling pathway GO:0002767 3 0.912
positive regulation of myeloid leukocyte mediated immunity GO:0002888 14 0.912
positive regulation of exocytosis GO:0045921 20 0.910
alpha beta t cell differentiation GO:0046632 69 0.906
regulation of response to wounding GO:1903034 189 0.906
regulation of t cell receptor signaling pathway GO:0050856 21 0.906
negative regulation of intracellular signal transduction GO:1902532 167 0.905
neutrophil migration GO:1990266 37 0.905
regulation of leukocyte proliferation GO:0070663 121 0.904
regulation of dendritic cell apoptotic process GO:2000668 3 0.902
leukocyte apoptotic process GO:0071887 71 0.894
regulation of intracellular transport GO:0032386 159 0.894
platelet degranulation GO:0002576 6 0.889
innate immune response activating signal transduction GO:0002758 50 0.889
positive regulation of cytokine production GO:0001819 174 0.888
mast cell degranulation GO:0043303 19 0.888
regulation of alpha beta t cell differentiation GO:0046637 35 0.888
cellular amino acid metabolic process GO:0006520 103 0.887
positive regulation of cell activation GO:0050867 158 0.885
regulation of mast cell activation involved in immune response GO:0033006 17 0.885
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 55 0.884
myeloid leukocyte activation GO:0002274 83 0.876
Mouse
mast cell mediated immunity GO:0002448 20 0.874
regulation of body fluid levels GO:0050878 162 0.873
regulation of inflammatory response to antigenic stimulus GO:0002861 21 0.868
positive regulation of adaptive immune response GO:0002821 61 0.866
positive regulation of phagocytosis GO:0050766 26 0.866
positive regulation of mast cell degranulation GO:0043306 10 0.864
lysosome localization GO:0032418 20 0.862
regulation of regulated secretory pathway GO:1903305 20 0.862
negative regulation of synapse assembly GO:0051964 3 0.860
leukocyte differentiation GO:0002521 342 0.858
regulation of mast cell degranulation GO:0043304 16 0.856
negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 23 0.854
negative regulation of homeostatic process GO:0032845 71 0.854
regulation of toll like receptor 4 signaling pathway GO:0034143 4 0.851
b cell activation GO:0042113 161 0.845
positive regulation of t cell activation GO:0050870 101 0.843
positive regulation of regulated secretory pathway GO:1903307 10 0.834
myeloid cell homeostasis GO:0002262 114 0.833
regulation of phagocytosis GO:0050764 33 0.833
regulation of platelet activation GO:0010543 17 0.832
regulated secretory pathway GO:0045055 32 0.824
actin cytoskeleton organization GO:0030036 220 0.822
negative regulation of cell activation GO:0050866 111 0.820
leukocyte homeostasis GO:0001776 79 0.819
regulation of tyrosine phosphorylation of stat5 protein GO:0042522 8 0.817
gamma delta t cell differentiation GO:0042492 11 0.816
regulation of cytokine production involved in immune response GO:0002718 26 0.814
positive regulation of hypersensitivity GO:0002885 7 0.814
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.814
Mouse
regulation of inflammatory response GO:0050727 147 0.807
positive regulation of b cell receptor signaling pathway GO:0050861 4 0.797
calcium ion transport GO:0006816 159 0.795
positive regulation of antigen receptor mediated signaling pathway GO:0050857 9 0.792
t cell differentiation GO:0030217 174 0.792
negative regulation of immune system process GO:0002683 209 0.789
regulation of toll like receptor signaling pathway GO:0034121 20 0.781
cation transport GO:0006812 399 0.778
negative regulation of map kinase activity GO:0043407 34 0.778
homeostasis of number of cells GO:0048872 210 0.777
mast cell activation involved in immune response GO:0002279 20 0.775
negative regulation of toll like receptor 2 signaling pathway GO:0034136 3 0.774
positive regulation of hydrolase activity GO:0051345 148 0.771
regulation of calcium mediated signaling GO:0050848 19 0.763
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.763
positive regulation of cysteine type endopeptidase activity GO:2001056 39 0.763
negative regulation of toll like receptor 4 signaling pathway GO:0034144 3 0.758
granulocyte migration GO:0097530 43 0.757
negative regulation of toll like receptor signaling pathway GO:0034122 14 0.754
positive regulation of tyrosine phosphorylation of stat5 protein GO:0042523 6 0.752
regulation of production of molecular mediator of immune response GO:0002700 65 0.743
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.736
regulation of hypersensitivity GO:0002883 10 0.730
alpha beta t cell activation GO:0046631 91 0.725
positive regulation of immune effector process GO:0002699 107 0.724
serotonin secretion by platelet GO:0002554 3 0.717
positive regulation of secretion by cell GO:1903532 114 0.716
regulation of defense response GO:0031347 233 0.716
regulation of immunoglobulin mediated immune response GO:0002889 37 0.715
regulation of cd4 positive alpha beta t cell activation GO:2000514 24 0.714
regulation of cellular ketone metabolic process GO:0010565 66 0.709
regulation of cellular amine metabolic process GO:0033238 20 0.708
positive regulation of intracellular transport GO:0032388 70 0.703
immune complex clearance GO:0002434 2 0.701
regulation of type iii hypersensitivity GO:0001803 3 0.701
lipopolysaccharide mediated signaling pathway GO:0031663 25 0.699
regulation of endocytosis GO:0030100 69 0.691
single organism cell adhesion GO:0098602 156 0.689
leukocyte degranulation GO:0043299 27 0.684
regulation of t cell differentiation GO:0045580 83 0.681
neutrophil activation GO:0042119 9 0.681
serotonin secretion involved in inflammatory response GO:0002442 4 0.680
cellular response to lipid GO:0071396 145 0.680
regulation of cd4 positive alpha beta t cell differentiation GO:0043370 21 0.679
granulocyte chemotaxis GO:0071621 39 0.677
positive regulation of apoptotic signaling pathway GO:2001235 95 0.676
cytokine production GO:0001816 319 0.675
production of molecular mediator of immune response GO:0002440 103 0.673
signal transduction in absence of ligand GO:0038034 55 0.665
apical constriction GO:0003383 4 0.663
negative regulation of protein metabolic process GO:0051248 282 0.663
regulation of leukocyte mediated immunity GO:0002703 104 0.663
positive regulation of gamma delta t cell activation GO:0046645 6 0.651
forebrain development GO:0030900 302 0.650
peptidyl tyrosine phosphorylation GO:0018108 143 0.644
regulation of exocytosis GO:0017157 61 0.642
fc receptor mediated inhibitory signaling pathway GO:0002774 1 0.640
negative regulation of b cell activation GO:0050869 27 0.639
regulation of transferase activity GO:0051338 263 0.630
negative regulation of erk1 and erk2 cascade GO:0070373 21 0.628
regulation of innate immune response GO:0045088 91 0.624
regulation of lymphocyte proliferation GO:0050670 117 0.622
regulation of kinase activity GO:0043549 249 0.621
toll like receptor signaling pathway GO:0002224 38 0.617
chemotaxis GO:0006935 247 0.616
Fly
negative regulation of myeloid leukocyte differentiation GO:0002762 20 0.613
regulation of interleukin 10 production GO:0032653 21 0.611
small gtpase mediated signal transduction GO:0007264 97 0.609
positive regulation of peptidase activity GO:0010952 49 0.607
regulation of cytokine production GO:0001817 266 0.601
negative regulation of leukocyte differentiation GO:1902106 51 0.600
defense response to bacterium GO:0042742 119 0.600
osteoclast differentiation GO:0030316 62 0.600
coagulation GO:0050817 78 0.596
regulation of homotypic cell cell adhesion GO:0034110 13 0.596
regulation of dendritic cell chemotaxis GO:2000508 1 0.594
tumor necrosis factor production GO:0032640 50 0.594
negative regulation of mapk cascade GO:0043409 65 0.592
cellular lipid metabolic process GO:0044255 323 0.592
positive regulation of granulocyte macrophage colony stimulating factor biosynthetic process GO:0045425 2 0.591
dendritic cell apoptotic process GO:0097048 3 0.590
antigen processing and presentation of exogenous peptide antigen GO:0002478 21 0.588
erk1 and erk2 cascade GO:0070371 77 0.580
positive regulation of t cell differentiation GO:0045582 52 0.579
regulation of phosphatidylinositol 3 kinase activity GO:0043551 14 0.574
neutrophil chemotaxis GO:0030593 36 0.573
lymphocyte proliferation GO:0046651 164 0.570
tyrosine phosphorylation of stat protein GO:0007260 23 0.568
g protein coupled receptor signaling pathway GO:0007186 243 0.566
inflammatory response to antigenic stimulus GO:0002437 30 0.564
regulation of natural killer cell activation GO:0032814 22 0.563
phospholipid metabolic process GO:0006644 87 0.562
positive regulation of t cell proliferation GO:0042102 52 0.562
regulation of type i hypersensitivity GO:0001810 4 0.555
b cell homeostasis GO:0001782 34 0.548
regulation of homeostatic process GO:0032844 182 0.541
positive regulation of acute inflammatory response to antigenic stimulus GO:0002866 7 0.539
leukocyte migration GO:0050900 124 0.538
negative regulation of protein serine threonine kinase activity GO:0071901 49 0.531
positive regulation of podosome assembly GO:0071803 3 0.530
i kappab kinase nf kappab signaling GO:0007249 85 0.529
phagocytosis GO:0006909 66 0.528
negative regulation of protein modification process GO:0031400 163 0.526
cellular ketone metabolic process GO:0042180 84 0.521
positive regulation of alpha beta t cell activation GO:0046635 39 0.512
regulation of vesicle mediated transport GO:0060627 139 0.511
ras protein signal transduction GO:0007265 77 0.511
rho protein signal transduction GO:0007266 32 0.509
response to molecule of bacterial origin GO:0002237 143 0.508
platelet activation GO:0030168 40 0.508
regulation of endopeptidase activity GO:0052548 89 0.507
t cell proliferation GO:0042098 120 0.506
cellular zinc ion homeostasis GO:0006882 9 0.506
antigen processing and presentation of exogenous peptide antigen via mhc class i GO:0042590 6 0.505
regulation of hydrolase activity GO:0051336 246 0.504
second messenger mediated signaling GO:0019932 73 0.503
gamma delta t cell activation GO:0046629 13 0.502
regulation of blood coagulation GO:0030193 28 0.502
cell chemotaxis GO:0060326 81 0.499
regulation of adaptive immune response GO:0002819 90 0.499
inflammatory response GO:0006954 244 0.495
cytosolic calcium ion homeostasis GO:0051480 70 0.495
endodermal cell fate specification GO:0001714 4 0.495
regulation of leukocyte degranulation GO:0043300 20 0.492
regulation of interleukin 2 production GO:0032663 28 0.492
regulation of apoptotic signaling pathway GO:2001233 197 0.489
membrane organization GO:0061024 245 0.487
regulation of secretion by cell GO:1903530 249 0.485
regulation of erk1 and erk2 cascade GO:0070372 71 0.483
fc receptor signaling pathway GO:0038093 6 0.480
cellular metal ion homeostasis GO:0006875 151 0.478
regulation of cell adhesion GO:0030155 154 0.469
Human
cell substrate adhesion GO:0031589 130 0.468
positive regulation of kinase activity GO:0033674 155 0.467
organelle localization GO:0051640 179 0.466
leukocyte mediated immunity GO:0002443 174 0.466
response to lipopolysaccharide GO:0032496 128 0.465
axonogenesis GO:0007409 274 0.463
Fly
regulation of t cell activation GO:0050863 170 0.459
b cell proliferation GO:0042100 53 0.459
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 61 0.458
cd4 positive alpha beta t cell differentiation GO:0043367 41 0.456
divalent metal ion transport GO:0070838 172 0.456
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 62 0.455
negative regulation of b cell mediated immunity GO:0002713 7 0.455
antigen processing and presentation of peptide antigen GO:0048002 29 0.454
cellular response to cytokine stimulus GO:0071345 189 0.451
olfactory learning GO:0008355 2 0.450
homotypic cell cell adhesion GO:0034109 28 0.450
regulation of b cell activation GO:0050864 81 0.447
neutrophil activation involved in immune response GO:0002283 8 0.443
protein localization to nucleus GO:0034504 121 0.443
actin filament organization GO:0007015 113 0.441
regulation of myeloid leukocyte mediated immunity GO:0002886 25 0.441
protein autophosphorylation GO:0046777 61 0.438
positive regulation of innate immune response GO:0045089 80 0.438
peptidyl tyrosine modification GO:0018212 145 0.437
activation of innate immune response GO:0002218 56 0.436
positive regulation of response to wounding GO:1903036 66 0.436
protein maturation GO:0051604 176 0.431
hemostasis GO:0007599 78 0.430
sequestering of metal ion GO:0051238 19 0.428
negative regulation of phosphorylation GO:0042326 166 0.427
regulation of hemostasis GO:1900046 28 0.425
erythrocyte differentiation GO:0030218 88 0.424
positive regulation of secretion GO:0051047 130 0.423
positive regulation of immunoglobulin mediated immune response GO:0002891 26 0.403
regulation of podosome assembly GO:0071801 3 0.403
regulation of jak stat cascade GO:0046425 34 0.401
negative regulation of t cell mediated immunity GO:0002710 9 0.400
positive regulation of cell development GO:0010720 237 0.398
positive regulation of production of molecular mediator of immune response GO:0002702 45 0.398
regulation of actin filament length GO:0030832 45 0.397
regulation of b cell mediated immunity GO:0002712 37 0.396
calcium mediated signaling GO:0019722 46 0.392
regulation of actin cytoskeleton organization GO:0032956 84 0.388
antigen processing and presentation of exogenous antigen GO:0019884 26 0.388
granulocyte activation GO:0036230 10 0.386
regulation of leukocyte differentiation GO:1902105 159 0.384
wound healing GO:0042060 157 0.382
lymphocyte homeostasis GO:0002260 64 0.382
negative regulation of insulin receptor signaling pathway GO:0046627 14 0.379
Mouse
type iia hypersensitivity GO:0001794 4 0.378
positive regulation of growth hormone receptor signaling pathway GO:0060399 3 0.374
cellular response to biotic stimulus GO:0071216 92 0.373
exocytosis GO:0006887 121 0.373
regulation of cell shape GO:0008360 39 0.368
serotonin production involved in inflammatory response GO:0002351 4 0.367
positive regulation of leukocyte apoptotic process GO:2000108 21 0.366
cytoplasmic transport GO:0016482 234 0.365
positive regulation of mast cell activation GO:0033005 12 0.363
positive regulation of mapk cascade GO:0043410 170 0.361
positive regulation of acute inflammatory response GO:0002675 16 0.361
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 36 0.360
type ii hypersensitivity GO:0002445 4 0.359
negative regulation of t helper 1 cell differentiation GO:0045626 3 0.358
glycosyl compound catabolic process GO:1901658 206 0.356
negative regulation of cellular component organization GO:0051129 194 0.355
negative regulation of mast cell proliferation GO:0070667 1 0.353
negative regulation of hypersensitivity GO:0002884 3 0.351
hematopoietic stem cell migration GO:0035701 1 0.349
Human
regulation of coagulation GO:0050818 31 0.348
negative regulation of apoptotic signaling pathway GO:2001234 104 0.344
cell type specific apoptotic process GO:0097285 268 0.342
activation of janus kinase activity GO:0042976 2 0.341
calcium ion homeostasis GO:0055074 127 0.334
b cell receptor signaling pathway GO:0050853 20 0.334
regulation of interleukin 6 production GO:0032675 55 0.332
plasma membrane organization GO:0007009 90 0.331
antigen processing and presentation of peptide or polysaccharide antigen via mhc class ii GO:0002504 17 0.331
mapk cascade GO:0000165 281 0.329
negative regulation of phosphorus metabolic process GO:0010563 184 0.328
cellular response to hormone stimulus GO:0032870 150 0.318
Mouse
purine ribonucleotide metabolic process GO:0009150 290 0.316
negative regulation of immune effector process GO:0002698 55 0.316
negative regulation of lymphocyte mediated immunity GO:0002707 21 0.315
regulation of peptidyl tyrosine phosphorylation GO:0050730 93 0.313
response to metal ion GO:0010038 47 0.311
positive regulation of programmed cell death GO:0043068 218 0.310
actin polymerization or depolymerization GO:0008154 54 0.309
positive regulation of b cell activation GO:0050871 49 0.308
regulation of ion transport GO:0043269 215 0.307
regulation of dendritic cell cytokine production GO:0002730 2 0.301
type i hypersensitivity GO:0016068 4 0.300
positive regulation of t cell mediated cytotoxicity GO:0001916 15 0.300
negative regulation of lymphocyte proliferation GO:0050672 45 0.297
response to alcohol GO:0097305 48 0.296
peptidyl amino acid modification GO:0018193 336 0.295
regulation of map kinase activity GO:0043405 120 0.293
hypersensitivity GO:0002524 10 0.292
positive regulation of alpha beta t cell differentiation GO:0046638 28 0.291
single organismal cell cell adhesion GO:0016337 131 0.290
cellular response to lipopolysaccharide GO:0071222 77 0.290
positive regulation of tumor necrosis factor superfamily cytokine production GO:1903557 31 0.290
regulation of acute inflammatory response GO:0002673 27 0.290
regulation of lymphocyte differentiation GO:0045619 107 0.288
jak stat cascade GO:0007259 42 0.288
learning GO:0007612 98 0.287
positive regulation of humoral immune response GO:0002922 11 0.285
immunoglobulin mediated immune response GO:0016064 69 0.285
regulation of protein localization to nucleus GO:1900180 60 0.282
negative regulation of cellular protein metabolic process GO:0032269 247 0.279
positive regulation of map kinase activity GO:0043406 84 0.278
positive regulation of cytosolic calcium ion concentration GO:0007204 65 0.276
regulation of tumor necrosis factor superfamily cytokine production GO:1903555 50 0.274
regulation of cysteine type endopeptidase activity GO:2000116 65 0.274
neuron projection guidance GO:0097485 141 0.272
Fly
positive regulation of endopeptidase activity GO:0010950 43 0.270
regulation of tumor necrosis factor biosynthetic process GO:0042534 10 0.269
extrinsic apoptotic signaling pathway GO:0097191 126 0.268
positive regulation of protein kinase activity GO:0045860 144 0.267
regulation of humoral immune response mediated by circulating immunoglobulin GO:0002923 10 0.267
positive regulation of lymphocyte proliferation GO:0050671 70 0.267
positive regulation of type iia hypersensitivity GO:0001798 4 0.263
myeloid cell apoptotic process GO:0033028 22 0.261
activation of cysteine type endopeptidase activity GO:0097202 27 0.256
zymogen activation GO:0031638 41 0.255
humoral immune response mediated by circulating immunoglobulin GO:0002455 14 0.255
membrane invagination GO:0010324 17 0.254
regulation of phospholipase c activity GO:1900274 3 0.251
response to growth factor GO:0070848 198 0.248
regulation of protein kinase activity GO:0045859 232 0.247
actin filament bundle assembly GO:0051017 40 0.246
myeloid cell differentiation GO:0030099 233 0.245
innate immune response GO:0045087 157 0.245
modulation by virus of host process GO:0019054 2 0.240
memory GO:0007613 58 0.239
protein localization to membrane GO:0072657 108 0.239
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.239
cell adhesion GO:0007155 329 0.237
filtration diaphragm assembly GO:0036058 1 0.237
osteoclast development GO:0036035 9 0.234
guanosine containing compound catabolic process GO:1901069 144 0.233
positive regulation of transferase activity GO:0051347 167 0.232
leukocyte proliferation GO:0070661 172 0.232
positive regulation of jak stat cascade GO:0046427 22 0.231
negative regulation of antigen receptor mediated signaling pathway GO:0050858 16 0.229
b cell differentiation GO:0030183 78 0.229
compound eye development GO:0048749 1 0.228
glycoprotein metabolic process GO:0009100 116 0.225
regulation of wound healing GO:0061041 40 0.224
positive regulation of antimicrobial peptide biosynthetic process GO:0002807 1 0.224
negative regulation of alcohol biosynthetic process GO:1902931 4 0.223
regulation of rho gtpase activity GO:0032319 58 0.223
positive regulation of endocytosis GO:0045807 42 0.222
negative regulation of type i hypersensitivity GO:0001811 1 0.221
response to platelet derived growth factor GO:0036119 6 0.221
regulation of b cell apoptotic process GO:0002902 13 0.221
reactive nitrogen species metabolic process GO:2001057 0 0.220
cd4 positive alpha beta t cell activation GO:0035710 45 0.219
positive regulation of calcium mediated signaling GO:0050850 15 0.219
regulation of protein transport GO:0051223 163 0.219
cellular response to organonitrogen compound GO:0071417 145 0.218
Mouse
mast cell apoptotic process GO:0033024 5 0.216
positive regulation of leukocyte mediated immunity GO:0002705 70 0.214
platelet aggregation GO:0070527 20 0.214
regulation of phosphatidylinositol 3 kinase signaling GO:0014066 30 0.214
negative regulation of t cell activation GO:0050868 65 0.209
digestive tract development GO:0048565 190 0.208
regulation of protein secretion GO:0050708 82 0.207
regulation of myeloid leukocyte differentiation GO:0002761 58 0.207
positive regulation of phospholipase activity GO:0010518 3 0.206
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 45 0.205
regulation of peptidase activity GO:0052547 96 0.204
tumor necrosis factor biosynthetic process GO:0042533 10 0.204
regulation of cytoskeleton organization GO:0051493 122 0.202
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.202
interleukin 10 production GO:0032613 23 0.201
glucose transport GO:0015758 56 0.201
regulation of secretion GO:0051046 274 0.198
cellular chemical homeostasis GO:0055082 215 0.198
regulation of actin polymerization or depolymerization GO:0008064 45 0.197
gland development GO:0048732 330 0.197
digestive system development GO:0055123 200 0.194
negative regulation of lymphocyte apoptotic process GO:0070229 24 0.193
negative regulation of t cell mediated cytotoxicity GO:0001915 3 0.193
positive regulation of tyrosine phosphorylation of stat protein GO:0042531 15 0.193
antigen processing and presentation GO:0019882 47 0.192
parallel actin filament bundle assembly GO:0030046 2 0.191
anatomical structure homeostasis GO:0060249 145 0.190
carbohydrate derivative biosynthetic process GO:1901137 183 0.189
regulation of protein localization GO:0032880 231 0.188
endocytosis GO:0006897 168 0.187
protein processing GO:0016485 163 0.185
cation homeostasis GO:0055080 212 0.185
regulation of organelle organization GO:0033043 289 0.185
serotonin secretion GO:0001820 8 0.185
cellular response to organic cyclic compound GO:0071407 87 0.184
regulation of protein complex assembly GO:0043254 83 0.184
positive regulation of protein localization to nucleus GO:1900182 30 0.182
sensory perception GO:0007600 245 0.182
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 61 0.182
regulation of establishment of protein localization GO:0070201 181 0.181
myeloid leukocyte differentiation GO:0002573 119 0.180
ribonucleoside metabolic process GO:0009119 245 0.179
positive regulation of purine nucleotide catabolic process GO:0033123 88 0.177
positive regulation of type i hypersensitivity GO:0001812 3 0.177
tumor necrosis factor superfamily cytokine production GO:0071706 51 0.176
positive regulation of cd8 positive alpha beta t cell extravasation GO:2000451 2 0.176
t helper 17 cell chemotaxis GO:0035705 1 0.176
podosome assembly GO:0071800 6 0.176
positive regulation of nervous system development GO:0051962 221 0.176
protein secretion GO:0009306 111 0.174
negative regulation of cytokine production GO:0001818 84 0.174
regulation of calcium ion transport into cytosol GO:0010522 31 0.173
response to organonitrogen compound GO:0010243 246 0.172
Mouse
regulation of tyrosine phosphorylation of stat protein GO:0042509 20 0.172
positive regulation of muscle contraction GO:0045933 10 0.172
positive regulation of protein phosphorylation GO:0001934 242 0.172
microtubule based process GO:0007017 236 0.170
response to organic cyclic compound GO:0014070 198 0.170
regulation of metal ion transport GO:0010959 106 0.169
t cell mediated immunity GO:0002456 50 0.168
positive regulation of interleukin 10 production GO:0032733 12 0.167
negative regulation of phosphate metabolic process GO:0045936 184 0.167
regulation of mast cell proliferation GO:0070666 4 0.166
metal ion homeostasis GO:0055065 189 0.165
negative regulation of molecular function GO:0044092 258 0.165
intracellular receptor signaling pathway GO:0030522 74 0.164
negative regulation of leukocyte mediated immunity GO:0002704 29 0.163
protein localization to organelle GO:0033365 185 0.163
acute inflammatory response to antigenic stimulus GO:0002438 12 0.161
granulocyte macrophage colony stimulating factor biosynthetic process GO:0042253 2 0.160
lymphocyte mediated immunity GO:0002449 139 0.160
negative regulation of leukocyte apoptotic process GO:2000107 31 0.159
endomembrane system organization GO:0010256 147 0.159
cytokine secretion GO:0050663 72 0.158
nitrogen compound transport GO:0071705 271 0.158
interleukin 2 mediated signaling pathway GO:0038110 2 0.158
positive regulation of tumor necrosis factor production GO:0032760 30 0.157
reactive oxygen species metabolic process GO:0072593 84 0.156
gtp catabolic process GO:0006184 143 0.156
cellular response to growth factor stimulus GO:0071363 197 0.154
regulation of myeloid cell apoptotic process GO:0033032 19 0.154
intestinal epithelial cell differentiation GO:0060575 14 0.153
release of sequestered calcium ion into cytosol GO:0051209 42 0.152
calcium ion transport into cytosol GO:0060402 48 0.151

Ptprc disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
lupus erythematosus DOID:8857 0 0.854
immune system disease DOID:2914 0 0.854
hypersensitivity reaction disease DOID:0060056 0 0.854
disease of anatomical entity DOID:7 0 0.854
hypersensitivity reaction type ii disease DOID:417 0 0.854
systemic lupus erythematosus DOID:9074 0 0.619
musculoskeletal system disease DOID:17 0 0.619
connective tissue disease DOID:65 0 0.619
disease by infectious agent DOID:0050117 0 0.341
primary immunodeficiency disease DOID:612 0 0.254
severe combined immunodeficiency DOID:627 0 0.254
combined t cell and b cell immunodeficiency DOID:628 0 0.254