Mus musculus

217 known processes

Rb1

retinoblastoma 1

(Aliases: Rb-1,Rb,pRb)

Rb1 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
negative regulation of transcription involved in g1 s transition of mitotic cell cycle GO:0071930 1 1.000
negative regulation of cell cycle GO:0045786 123 1.000
cellular response to dna damage stimulus GO:0006974 207 1.000
regulation of somitogenesis GO:0014807 6 1.000
regionalization GO:0003002 337 1.000
glial cell apoptotic process GO:0034349 3 0.999
regulation of mitotic cell cycle GO:0007346 126 0.999
regulation of cell cycle GO:0051726 281 0.999
cellular response to antibiotic GO:0071236 4 0.999
negative regulation of cell cycle phase transition GO:1901988 48 0.999
negative regulation of cyclin dependent protein serine threonine kinase activity GO:0045736 9 0.999
cell cycle arrest GO:0007050 37 0.999
negative regulation of mitotic cell cycle GO:0045930 58 0.998
regulation of transcription involved in g1 s transition of mitotic cell cycle GO:0000083 3 0.998
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 57 0.998
g1 s transition of mitotic cell cycle GO:0000082 57 0.998
intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 35 0.997
somite specification GO:0001757 4 0.997
intrinsic apoptotic signaling pathway GO:0097193 132 0.997
negative regulation of blood vessel endothelial cell migration GO:0043537 3 0.996
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 16 0.996
mitotic g1 dna damage checkpoint GO:0031571 4 0.996
regulation of cell cycle g1 s phase transition GO:1902806 35 0.995
signal transduction by p53 class mediator GO:0072331 51 0.995
regulation of cell cycle phase transition GO:1901987 77 0.995
intra s dna damage checkpoint GO:0031573 4 0.991
negative regulation of mitotic cell cycle phase transition GO:1901991 45 0.991
dna metabolic process GO:0006259 303 0.991
negative regulation of protein serine threonine kinase activity GO:0071901 49 0.989
mitotic cell cycle process GO:1903047 159 0.989
negative regulation of glial cell proliferation GO:0060253 4 0.989
cell cycle g1 s phase transition GO:0044843 57 0.988
apoptotic signaling pathway GO:0097190 306 0.987
negative regulation of cell proliferation GO:0008285 296 0.987
regulation of kinase activity GO:0043549 249 0.987
Human
regulation of g1 s transition of mitotic cell cycle GO:2000045 35 0.982
regulation of transferase activity GO:0051338 263 0.978
Human
negative regulation of protein phosphorylation GO:0001933 126 0.977
Human
regulation of protein kinase activity GO:0045859 232 0.977
Human
regulation of mitotic cell cycle phase transition GO:1901990 73 0.977
negative regulation of immune system process GO:0002683 209 0.973
somite development GO:0061053 81 0.972
negative regulation of cell cycle process GO:0010948 69 0.969
carbon catabolite activation of transcription GO:0045991 4 0.969
sensory perception of sound GO:0007605 97 0.966
neural precursor cell proliferation GO:0061351 121 0.966
t cell activation GO:0042110 289 0.966
negative regulation of molecular function GO:0044092 258 0.963
Human
somitogenesis GO:0001756 69 0.962
regulation of cell cycle process GO:0010564 160 0.962
embryonic organ morphogenesis GO:0048562 276 0.961
Worm
regulation of cell adhesion GO:0030155 154 0.961
cell fate commitment GO:0045165 210 0.960
macroautophagy GO:0016236 21 0.960
negative regulation of photoreceptor cell differentiation GO:0046533 4 0.958
auditory receptor cell fate determination GO:0042668 3 0.956
cellular response to external stimulus GO:0071496 88 0.955
dna damage response signal transduction by p53 class mediator GO:0030330 19 0.955
negative regulation of cellular protein metabolic process GO:0032269 247 0.955
Human
mitotic cell cycle GO:0000278 195 0.955
neuron apoptotic process GO:0051402 142 0.950
regulation of auditory receptor cell differentiation GO:0045607 4 0.948
regulation of response to dna damage stimulus GO:2001020 34 0.944
autophagy GO:0006914 45 0.944
dendrite development GO:0016358 115 0.943
chromatin modification GO:0016568 187 0.943
muscle tissue development GO:0060537 308 0.942
regulation of cellular amino acid metabolic process GO:0006521 5 0.941
gland development GO:0048732 330 0.939
negative regulation of protein metabolic process GO:0051248 282 0.938
Human
signal transduction involved in dna integrity checkpoint GO:0072401 3 0.936
positive regulation of protein modification process GO:0031401 299 0.935
dna damage checkpoint GO:0000077 26 0.929
lymphocyte differentiation GO:0030098 242 0.929
chromatin organization GO:0006325 206 0.925
covalent chromatin modification GO:0016569 163 0.924
cellular ketone metabolic process GO:0042180 84 0.923
regulation of neuron apoptotic process GO:0043523 122 0.919
blastocyst development GO:0001824 80 0.919
cell type specific apoptotic process GO:0097285 268 0.918
negative regulation of epithelial cell proliferation GO:0050680 64 0.916
stem cell maintenance GO:0019827 130 0.915
positive regulation of apoptotic process GO:0043065 217 0.912
myeloid cell differentiation GO:0030099 233 0.912
negative regulation of phosphorylation GO:0042326 166 0.909
Human
negative regulation of t cell proliferation GO:0042130 38 0.907
regulation of microtubule polymerization GO:0031113 7 0.904
midbrain hindbrain boundary morphogenesis GO:0021555 4 0.902
male gamete generation GO:0048232 285 0.900
notch signaling pathway GO:0007219 71 0.898
negative regulation of g1 s transition of mitotic cell cycle GO:2000134 18 0.897
cell adhesion GO:0007155 329 0.891
mitotic cell cycle arrest GO:0071850 4 0.888
Worm
signal transduction involved in dna damage checkpoint GO:0072422 3 0.887
regulation of cohesin localization to chromatin GO:0071922 1 0.887
Human
protein catabolic process GO:0030163 221 0.885
Human
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 55 0.879
regulation of lymphocyte proliferation GO:0050670 117 0.878
somatic stem cell maintenance GO:0035019 47 0.868
positive regulation of neuron death GO:1901216 28 0.867
dna damage response signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 3 0.867
regulation of embryonic development GO:0045995 71 0.862
cellular amine metabolic process GO:0044106 44 0.861
blood vessel morphogenesis GO:0048514 285 0.856
forebrain development GO:0030900 302 0.853
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.853
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.850
angiogenesis GO:0001525 201 0.849
muscle cell differentiation GO:0042692 261 0.849
liver development GO:0001889 66 0.846
dna integrity checkpoint GO:0031570 28 0.840
response to nutrient levels GO:0031667 109 0.838
regulation of autophagy GO:0010506 30 0.837
cellular amino acid metabolic process GO:0006520 103 0.837
regulation of protein serine threonine kinase activity GO:0071900 157 0.835
renal system development GO:0072001 225 0.833
striated muscle tissue development GO:0014706 293 0.831
organelle localization GO:0051640 179 0.822
Human
skeletal muscle organ development GO:0060538 163 0.821
regulation of photoreceptor cell differentiation GO:0046532 4 0.819
negative regulation of growth GO:0045926 99 0.819
negative regulation of neural precursor cell proliferation GO:2000178 18 0.817
regulation of hydrolase activity GO:0051336 246 0.816
metanephric nephron tubule formation GO:0072289 4 0.814
negative regulation of cell cycle g1 s phase transition GO:1902807 18 0.813
negative regulation of intracellular signal transduction GO:1902532 167 0.810
negative regulation of auditory receptor cell differentiation GO:0045608 2 0.806
regulation of lymphocyte activation GO:0051249 240 0.801
cell cycle checkpoint GO:0000075 47 0.794
cellular response to toxic substance GO:0097237 7 0.793
signal transduction involved in mitotic dna damage checkpoint GO:1902402 3 0.792
regulation of cardiac cell fate specification GO:2000043 1 0.792
negative regulation of leukocyte proliferation GO:0070664 46 0.791
negative regulation of oxidative stress induced intrinsic apoptotic signaling pathway GO:1902176 4 0.788
positive regulation of rac protein signal transduction GO:0035022 1 0.788
negative regulation of pancreatic a cell differentiation GO:2000227 1 0.780
leukocyte differentiation GO:0002521 342 0.779
heart morphogenesis GO:0003007 178 0.777
cardiac chamber development GO:0003205 108 0.775
extrinsic apoptotic signaling pathway GO:0097191 126 0.775
cellular response to oxidative stress GO:0034599 76 0.775
regulation of epithelial cell proliferation GO:0050678 141 0.774
negative regulation of leukocyte differentiation GO:1902106 51 0.773
dna catabolic process GO:0006308 19 0.773
dna biosynthetic process GO:0071897 22 0.771
regulation of neuroblast proliferation GO:1902692 27 0.771
response to light stimulus GO:0009416 135 0.761
negative regulation of endothelial cell migration GO:0010596 4 0.761
protein autophosphorylation GO:0046777 61 0.761
cellular response to extracellular stimulus GO:0031668 81 0.760
cardiac endothelial cell differentiation GO:0003348 4 0.759
regulation of neural precursor cell proliferation GO:2000177 70 0.758
intracellular signal transduction involved in g1 dna damage checkpoint GO:1902400 3 0.756
protein kinase b signaling GO:0043491 74 0.756
positive regulation of epithelial cell proliferation GO:0050679 68 0.749
response to radiation GO:0009314 165 0.749
negative regulation of lymphocyte activation GO:0051250 91 0.745
negative regulation of neurotransmitter secretion GO:0046929 5 0.745
sensory perception of mechanical stimulus GO:0050954 107 0.742
positive regulation of apoptotic signaling pathway GO:2001235 95 0.741
signal transduction involved in cell cycle checkpoint GO:0072395 3 0.740
inner ear receptor cell differentiation GO:0060113 61 0.737
positive regulation of bmp signaling pathway GO:0030513 23 0.734
regulation of cellular amine metabolic process GO:0033238 20 0.732
regulation of pro b cell differentiation GO:2000973 5 0.730
negative regulation of transferase activity GO:0051348 85 0.730
Human
negative regulation of epidermal cell differentiation GO:0045605 7 0.728
cellular response to growth factor stimulus GO:0071363 197 0.728
negative regulation of cell activation GO:0050866 111 0.726
anoikis GO:0043276 6 0.718
regulation of intracellular transport GO:0032386 159 0.716
regulation of binding GO:0051098 111 0.713
negative regulation of lymphocyte proliferation GO:0050672 45 0.711
positive regulation of cellular amine metabolic process GO:0033240 5 0.709
negative regulation of oligodendrocyte differentiation GO:0048715 11 0.704
branching morphogenesis of an epithelial tube GO:0048754 159 0.699
mitotic sister chromatid cohesion GO:0007064 1 0.698
Human
positive regulation of mitotic cell cycle phase transition GO:1901992 17 0.695
Human
neuroblast differentiation GO:0014016 2 0.694
auditory receptor cell differentiation GO:0042491 37 0.694
neuroblast proliferation GO:0007405 49 0.693
digestive system development GO:0055123 200 0.690
signal transduction in absence of ligand GO:0038034 55 0.690
regulation of endothelial cell proliferation GO:0001936 23 0.686
spermatogenesis GO:0007283 284 0.683
sprouting angiogenesis GO:0002040 26 0.677
positive regulation of cell development GO:0010720 237 0.677
response to ionizing radiation GO:0010212 42 0.674
cellular response to abiotic stimulus GO:0071214 56 0.673
leukocyte proliferation GO:0070661 172 0.671
activation of cysteine type endopeptidase activity GO:0097202 27 0.658
negative regulation of cell growth GO:0030308 44 0.656
intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 19 0.652
developmental programmed cell death GO:0010623 41 0.651
intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator GO:0042771 24 0.650
negative regulation of dna replication GO:0008156 4 0.649
epithelial cell proliferation involved in prostate gland development GO:0060767 11 0.647
regulation of leukocyte differentiation GO:1902105 159 0.646
negative regulation of mechanoreceptor differentiation GO:0045632 3 0.646
positive regulation of transcription by galactose GO:0000411 1 0.645
ascending aorta morphogenesis GO:0035910 3 0.645
neuron death GO:0070997 154 0.641
germ cell development GO:0007281 185 0.641
response to oxygen levels GO:0070482 62 0.640
negative regulation of inner ear receptor cell differentiation GO:2000981 3 0.639
cell division GO:0051301 120 0.638
mitotic cell cycle checkpoint GO:0007093 31 0.637
negative regulation of glial cell differentiation GO:0045686 21 0.636
positive regulation of reactive oxygen species metabolic process GO:2000379 11 0.634
spermatid differentiation GO:0048515 115 0.634
developmental maturation GO:0021700 193 0.633
keratinocyte differentiation GO:0030216 48 0.632
dna replication GO:0006260 52 0.631
regulation of cell growth GO:0001558 91 0.628
cell growth GO:0016049 130 0.628
cation transport GO:0006812 399 0.627
negative regulation of kinase activity GO:0033673 81 0.624
Human
stomach neuroendocrine cell differentiation GO:0061102 2 0.623
segment specification GO:0007379 15 0.622
regulation of epidermal cell differentiation GO:0045604 21 0.622
positive regulation of transcription from rna polymerase ii promoter in response to stress GO:0036003 3 0.621
sperm individualization GO:0007291 1 0.620
ear development GO:0043583 200 0.618
cellular response to nutrient levels GO:0031669 64 0.617
cellular response to ionizing radiation GO:0071479 11 0.608
pallium development GO:0021543 120 0.603
positive regulation of myeloid cell differentiation GO:0045639 43 0.602
negative regulation of epidermis development GO:0045683 9 0.602
regulation of protein kinase b signaling GO:0051896 56 0.600
hair cell differentiation GO:0035315 40 0.598
positive regulation of neuron apoptotic process GO:0043525 25 0.598
stem cell proliferation GO:0072089 117 0.596
epithelial tube morphogenesis GO:0060562 303 0.595
digestive tract development GO:0048565 190 0.595
positive regulation of binding GO:0051099 49 0.589
positive regulation of neuroblast proliferation GO:0002052 19 0.589
regulation of t cell proliferation GO:0042129 92 0.585
central nervous system neuron differentiation GO:0021953 162 0.581
epithelial cell differentiation involved in prostate gland development GO:0060742 13 0.581
pole plasm assembly GO:0007315 2 0.575
stem cell differentiation GO:0048863 268 0.571
positive regulation of protein phosphorylation GO:0001934 242 0.571
neuroblast fate determination GO:0007400 1 0.570
erythrocyte differentiation GO:0030218 88 0.569
regulation of protein localization GO:0032880 231 0.567
Human
regulation of protein processing GO:0070613 96 0.563
skeletal muscle cell differentiation GO:0035914 66 0.562
negative regulation of protein processing GO:0010955 79 0.560
outflow tract morphogenesis GO:0003151 53 0.560
nuclear division GO:0000280 158 0.559
Human
regulation of inner ear receptor cell differentiation GO:2000980 5 0.559
columnar cuboidal epithelial cell differentiation GO:0002065 82 0.557
positive regulation of notch signaling pathway GO:0045747 18 0.557
regulation of leukocyte proliferation GO:0070663 121 0.557
regulation of reactive oxygen species metabolic process GO:2000377 40 0.555
regulation of oligodendrocyte differentiation GO:0048713 23 0.555
cohesin localization to chromatin GO:0071921 1 0.551
Human
response to organonitrogen compound GO:0010243 246 0.550
embryonic epithelial tube formation GO:0001838 130 0.543
positive regulation of osteoblast differentiation GO:0045669 34 0.540
artery development GO:0060840 53 0.538
negative regulation of lymphocyte differentiation GO:0045620 32 0.537
proximal distal pattern formation involved in nephron development GO:0072047 5 0.535
stem cell fate specification GO:0048866 3 0.533
regulation of myeloid cell differentiation GO:0045637 96 0.532
macromolecule methylation GO:0043414 120 0.529
positive regulation of mitotic sister chromatid separation GO:1901970 2 0.529
Human
axonogenesis GO:0007409 274 0.519
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.518
cellular macromolecule catabolic process GO:0044265 206 0.516
Human
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.516
diencephalon development GO:0021536 63 0.511
morphogenesis of a branching epithelium GO:0061138 193 0.509
regulation of neuron death GO:1901214 134 0.509
negative regulation of stomach neuroendocrine cell differentiation GO:0061106 1 0.508
protein methylation GO:0006479 81 0.507
cellular homeostasis GO:0019725 240 0.506
response to decreased oxygen levels GO:0036293 59 0.505
positive regulation of programmed cell death GO:0043068 218 0.505
segmentation GO:0035282 93 0.504
kidney development GO:0001822 213 0.499
regulation of transforming growth factor beta receptor signaling pathway GO:0017015 43 0.497
response to extracellular stimulus GO:0009991 127 0.495
regulation of dna replication GO:0006275 17 0.493
cardiac right ventricle formation GO:0003219 3 0.493
lateral inhibition GO:0046331 1 0.491
negative regulation of immature t cell proliferation GO:0033087 3 0.490
positive regulation of insulin secretion GO:0032024 26 0.490
extracellular matrix organization GO:0030198 147 0.490
dna damage response signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 2 0.487
regulation of cellular ketone metabolic process GO:0010565 66 0.485
cellular response to peptide hormone stimulus GO:0071375 92 0.484
epithelial cell proliferation GO:0050673 174 0.483
placenta blood vessel development GO:0060674 31 0.481
regulation of cell substrate adhesion GO:0010810 73 0.481
regulation of nucleocytoplasmic transport GO:0046822 73 0.480
regulation of cellular response to stress GO:0080135 159 0.480
signal transduction in response to dna damage GO:0042770 21 0.477
cell maturation GO:0048469 127 0.477
regulation of protein import into nucleus translocation GO:0033158 2 0.476
digestive tract morphogenesis GO:0048546 147 0.475
Worm
negative regulation of proteolysis involved in cellular protein catabolic process GO:1903051 22 0.473
t cell proliferation GO:0042098 120 0.472
oocyte differentiation GO:0009994 35 0.472
blood vessel lumenization GO:0072554 2 0.472
microtubule based process GO:0007017 236 0.469
Human
negative regulation of notch signaling pathway GO:0045746 14 0.469
positive regulation of proteolysis GO:0045862 85 0.468
Human
neuron maturation GO:0042551 29 0.466
negative regulation of phosphate metabolic process GO:0045936 184 0.465
Human
hepaticobiliary system development GO:0061008 67 0.465
myeloid leukocyte differentiation GO:0002573 119 0.465
positive regulation of cell death GO:0010942 224 0.464
positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090100 43 0.462
negative regulation of phosphatidylinositol 3 kinase activity GO:0043553 1 0.460
histone methylation GO:0016571 71 0.454
carbohydrate homeostasis GO:0033500 128 0.451
positive regulation of rap gtpase activity GO:0032854 3 0.447
positive regulation of lens epithelial cell proliferation GO:2001111 1 0.446
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.446
negative regulation of proteolysis GO:0045861 74 0.445
signal transduction involved in mitotic cell cycle checkpoint GO:0072413 3 0.434
positive regulation of mitotic cell cycle GO:0045931 41 0.432
Human
peptidyl amino acid modification GO:0018193 336 0.427
negative regulation of protein maturation GO:1903318 79 0.427
female gamete generation GO:0007292 74 0.424
epithelial tube formation GO:0072175 130 0.424
posttranscriptional regulation of gene expression GO:0010608 155 0.423
blastocyst growth GO:0001832 23 0.422
cellular response to cytokine stimulus GO:0071345 189 0.418
positive regulation of microtubule polymerization GO:0031116 3 0.417
atrioventricular node development GO:0003162 3 0.417
positive regulation of ras protein signal transduction GO:0046579 13 0.414
labyrinthine layer blood vessel development GO:0060716 21 0.412
regulation of epithelial cell proliferation involved in prostate gland development GO:0060768 10 0.412
signal transduction involved in mitotic g1 dna damage checkpoint GO:0072431 3 0.409
nucleocytoplasmic transport GO:0006913 139 0.408
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 34 0.408
lymphocyte proliferation GO:0046651 164 0.406
pro b cell differentiation GO:0002328 10 0.406
regulation of cell activation GO:0050865 289 0.405
circadian rhythm GO:0007623 114 0.404
morphogenesis of an endothelium GO:0003159 2 0.404
b cell activation GO:0042113 161 0.404
positive regulation of glial cell differentiation GO:0045687 21 0.403
mapk cascade GO:0000165 281 0.402
photoreceptor cell morphogenesis GO:0008594 3 0.400
endocardial cushion to mesenchymal transition involved in heart valve formation GO:0003199 4 0.400
endodermal cell fate determination GO:0007493 2 0.399
oocyte axis specification GO:0007309 2 0.399
negative regulation of neuron death GO:1901215 98 0.397
mitotic sister chromatid separation GO:0051306 9 0.397
Human
negative regulation of b cell proliferation GO:0030889 13 0.397
negative regulation of fibroblast migration GO:0010764 2 0.394
positive regulation of kinase activity GO:0033674 155 0.393
sister chromatid cohesion GO:0007062 12 0.390
Human
regulation of androgen receptor signaling pathway GO:0060765 3 0.390
positive regulation of transferase activity GO:0051347 167 0.389
positive regulation of endothelial cell proliferation GO:0001938 17 0.389
respiratory tube development GO:0030323 167 0.387
response to uv GO:0009411 44 0.381
negative regulation of synaptic vesicle exocytosis GO:2000301 3 0.378
response to hypoxia GO:0001666 58 0.375
blood vessel endothelial cell migration GO:0043534 23 0.374
epidermis development GO:0008544 187 0.373
negative regulation of t cell activation GO:0050868 65 0.370
negative regulation of neuron apoptotic process GO:0043524 92 0.370
oogenesis GO:0048477 56 0.366
skin development GO:0043588 220 0.365
neural tube development GO:0021915 160 0.365
ventricular septum morphogenesis GO:0060412 27 0.364
regulation of protein stability GO:0031647 52 0.363
regulation of endopeptidase activity GO:0052548 89 0.363
regulation of cell size GO:0008361 72 0.362
monocyte differentiation GO:0030224 9 0.358
protein maturation GO:0051604 176 0.358
gliogenesis GO:0042063 141 0.358
protein processing GO:0016485 163 0.358
positive regulation of transcription by glucose GO:0046016 3 0.353
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 40 0.350
regulation of sister chromatid cohesion GO:0007063 5 0.349
Human
intrahepatic bile duct development GO:0035622 2 0.349
membrane organization GO:0061024 245 0.348
regulation of neuron differentiation GO:0045664 281 0.348
negative regulation of nervous system development GO:0051961 156 0.347
sensory perception GO:0007600 245 0.347
spermatid development GO:0007286 108 0.346
positive regulation of histone methylation GO:0031062 16 0.344
negative regulation of cell development GO:0010721 169 0.343
dna catabolic process endonucleolytic GO:0000737 15 0.343
gastrulation GO:0007369 116 0.342
response to peptide GO:1901652 136 0.341
positive regulation of autophagy GO:0010508 9 0.338
purine nucleoside metabolic process GO:0042278 241 0.335
regulation of myeloid leukocyte differentiation GO:0002761 58 0.335
purine nucleotide metabolic process GO:0006163 302 0.335
response to x ray GO:0010165 11 0.330
positive regulation of keratinocyte differentiation GO:0045618 3 0.330
positive regulation of cysteine type endopeptidase activity GO:2001056 39 0.329
negative regulation of phosphorus metabolic process GO:0010563 184 0.329
Human
mitochondrial dna repair GO:0043504 3 0.329
embryonic skeletal system development GO:0048706 120 0.328
regulation of anoikis GO:2000209 2 0.328
megakaryocyte differentiation GO:0030219 26 0.327
cardiac muscle tissue development GO:0048738 130 0.326
cell fate determination GO:0001709 32 0.325
positive regulation of mitotic cell cycle embryonic GO:0045977 2 0.324
regulation of dna templated transcription in response to stress GO:0043620 9 0.324
regulation of histone methylation GO:0031060 30 0.323
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 11 0.322
actin filament organization GO:0007015 113 0.322
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 27 0.318
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.317
single organismal cell cell adhesion GO:0016337 131 0.315
smoothened signaling pathway GO:0007224 105 0.314
stem cell development GO:0048864 219 0.312
negative regulation of mesodermal cell fate specification GO:0042662 3 0.311
histone modification GO:0016570 159 0.309
canonical wnt signaling pathway GO:0060070 130 0.309
forebrain radial glial cell differentiation GO:0021861 4 0.309
regulation of gliogenesis GO:0014013 50 0.308
neural crest cell development GO:0014032 48 0.307
cellular response to inorganic substance GO:0071241 37 0.306
modification dependent protein catabolic process GO:0019941 133 0.305
Human
protein localization to nucleus GO:0034504 121 0.304
regulation of canonical wnt signaling pathway GO:0060828 82 0.302
sensory organ boundary specification GO:0008052 1 0.302
ras protein signal transduction GO:0007265 77 0.302
Human
microtubule polymerization or depolymerization GO:0031109 26 0.301
regulation of cysteine type endopeptidase activity GO:2000116 65 0.301
establishment of vesicle localization GO:0051650 81 0.300
response to endoplasmic reticulum stress GO:0034976 53 0.299
positive regulation of wound healing GO:0090303 17 0.296
cellular response to organonitrogen compound GO:0071417 145 0.296
regulation of cardiac muscle tissue growth GO:0055021 26 0.296
negative regulation of macroautophagy GO:0016242 5 0.296
compound eye development GO:0048749 1 0.291
regulation of notch signaling pathway GO:0008593 35 0.291
endodermal cell fate specification GO:0001714 4 0.290
dna endoreduplication GO:0042023 4 0.288
positive regulation of histone modification GO:0031058 28 0.287
microtubule polymerization GO:0046785 12 0.287
negative regulation of astrocyte differentiation GO:0048712 10 0.287
neural tube closure GO:0001843 90 0.283
telencephalon development GO:0021537 186 0.282
heterocycle catabolic process GO:0046700 280 0.282
peripheral nervous system neuron axonogenesis GO:0048936 3 0.281
myeloid cell homeostasis GO:0002262 114 0.280
negative regulation of anoikis GO:2000811 2 0.278
zymogen activation GO:0031638 41 0.276
negative regulation of cellular catabolic process GO:0031330 47 0.276
ureteric bud development GO:0001657 94 0.275
schwann cell proliferation GO:0014010 2 0.274
fat cell differentiation GO:0045444 160 0.274
cellular response to transforming growth factor beta stimulus GO:0071560 88 0.273
endothelial tube morphogenesis GO:0061154 2 0.272
positive regulation of transcription from rna polymerase ii promoter by glucose GO:0000432 3 0.271
positive regulation of keratinocyte proliferation GO:0010838 4 0.271
positive regulation of myeloid cell apoptotic process GO:0033034 4 0.271
negative regulation of tor signaling GO:0032007 13 0.270
regulation of timing of neuron differentiation GO:0060164 5 0.269
negative regulation of lipid kinase activity GO:0090219 1 0.268
protein localization to chromatin GO:0071168 3 0.268
Human
somite rostral caudal axis specification GO:0032525 13 0.266
regulation of exocytosis GO:0017157 61 0.265
negative regulation of dendritic spine morphogenesis GO:0061002 3 0.265
neuron projection guidance GO:0097485 141 0.262
cellular response to drug GO:0035690 15 0.262
cellular response to metal ion GO:0071248 31 0.261
mechanoreceptor differentiation GO:0042490 67 0.260
protein alkylation GO:0008213 81 0.259
protein targeting GO:0006605 143 0.257
regulation of protein maturation GO:1903317 96 0.255
locomotory behavior GO:0007626 195 0.254
ascending aorta development GO:0035905 3 0.254
positive regulation of apoptotic process involved in mammary gland involution GO:0060058 4 0.254
extracellular structure organization GO:0043062 148 0.253

Rb1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 0 0.998
Human
cancer DOID:162 0 0.980
Human
organ system cancer DOID:0050686 0 0.980
Human
endocrine gland cancer DOID:170 0 0.951
thoracic cancer DOID:5093 0 0.636
pancreatic cancer DOID:1793 0 0.605
disease of metabolism DOID:0014667 0 0.599
immune system cancer DOID:0060083 0 0.556
hematologic cancer DOID:2531 0 0.556
sensory system disease DOID:0050155 0 0.397
disease of anatomical entity DOID:7 0 0.397
nervous system disease DOID:863 0 0.397
respiratory system cancer DOID:0050615 0 0.366
Human
large intestine cancer DOID:5672 0 0.266
colon cancer DOID:219 0 0.266
gastrointestinal system cancer DOID:3119 0 0.266
intestinal cancer DOID:10155 0 0.266
colorectal cancer DOID:9256 0 0.266