Mus musculus

70 known processes

Rpa1

replication protein A1

(Aliases: AW557552,AA589576,70kDa,Rpa,RF-A,RP-A,5031405K23Rik)

Rpa1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
double strand break repair via nonhomologous end joining GO:0006303 10 0.480
protein modification by small protein conjugation or removal GO:0070647 207 0.479
Yeast
dna dependent dna replication GO:0006261 24 0.448
Yeast
deoxyribonucleotide biosynthetic process GO:0009263 6 0.422
dna repair GO:0006281 107 0.412
cellular response to dna damage stimulus GO:0006974 207 0.363
dna metabolic process GO:0006259 303 0.326
regulation of rna polymerase ii transcriptional preinitiation complex assembly GO:0045898 2 0.278
chromatin organization GO:0006325 206 0.253
cell cycle checkpoint GO:0000075 47 0.239
intra s dna damage checkpoint GO:0031573 4 0.213
meiosis i GO:0007127 60 0.180
Yeast
inner cell mass cell proliferation GO:0001833 15 0.178
recombinational repair GO:0000725 21 0.178
mitotic cell cycle GO:0000278 195 0.173
protein modification by small protein conjugation GO:0032446 187 0.148
Yeast
organelle fission GO:0048285 170 0.141
nucleobase containing small molecule metabolic process GO:0055086 352 0.119
negative regulation of cell cycle process GO:0010948 69 0.106
dna unwinding involved in dna replication GO:0006268 5 0.099
Yeast
dna recombination GO:0006310 92 0.095
protein dna complex subunit organization GO:0071824 28 0.095
meiotic cell cycle process GO:1903046 77 0.094
Yeast
positive regulation of cellular amine metabolic process GO:0033240 5 0.086
cellular amino acid metabolic process GO:0006520 103 0.084
regulation of mitotic cell cycle phase transition GO:1901990 73 0.083
dna conformation change GO:0071103 37 0.083
Yeast
positive regulation of rna polymerase ii transcriptional preinitiation complex assembly GO:0045899 2 0.082
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.080
ras protein signal transduction GO:0007265 77 0.079
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.078
cell fate commitment GO:0045165 210 0.072
base excision repair GO:0006284 9 0.071
Human
chromosome organization involved in meiosis GO:0070192 39 0.066
meiotic cell cycle GO:0051321 122 0.065
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.063
non recombinational repair GO:0000726 10 0.062
dna replication checkpoint GO:0000076 2 0.061
cellular ketone metabolic process GO:0042180 84 0.060
small gtpase mediated signal transduction GO:0007264 97 0.058
negative regulation of cell cycle GO:0045786 123 0.057
positive regulation of transcription initiation from rna polymerase ii promoter GO:0060261 5 0.055
microtubule cytoskeleton organization GO:0000226 157 0.055
purine containing compound metabolic process GO:0072521 311 0.055
microtubule based process GO:0007017 236 0.051
mitotic cell cycle process GO:1903047 159 0.051
response to radiation GO:0009314 165 0.049
regulation of intracellular transport GO:0032386 159 0.049
dna templated transcriptional preinitiation complex assembly GO:0070897 4 0.048
protein ubiquitination GO:0016567 171 0.047
Yeast
regulation of cellular amino acid metabolic process GO:0006521 5 0.046
histone acetylation GO:0016573 41 0.046
negative regulation of molecular function GO:0044092 258 0.046
intracellular protein transport GO:0006886 204 0.046
dna integrity checkpoint GO:0031570 28 0.046
nucleoside phosphate biosynthetic process GO:1901293 79 0.044
cell chemotaxis GO:0060326 81 0.043
regulation of hydrolase activity GO:0051336 246 0.043
Worm
organelle assembly GO:0070925 177 0.043
alpha amino acid metabolic process GO:1901605 59 0.043
amine metabolic process GO:0009308 45 0.042
histone modification GO:0016570 159 0.040
negative regulation of mitotic cell cycle GO:0045930 58 0.040
methylation GO:0032259 134 0.040
peptidyl amino acid modification GO:0018193 336 0.039
positive regulation of dna templated transcription initiation GO:2000144 5 0.039
double strand break repair GO:0006302 48 0.039
mitotic g1 dna damage checkpoint GO:0031571 4 0.037
blastocyst growth GO:0001832 23 0.037
regulation of chromosome organization GO:0033044 83 0.037
purine nucleotide metabolic process GO:0006163 302 0.036
cellular protein complex assembly GO:0043623 116 0.036
meiotic chromosome segregation GO:0045132 19 0.033
carbohydrate derivative biosynthetic process GO:1901137 183 0.033
regulation of histone modification GO:0031056 56 0.032
chemotaxis GO:0006935 247 0.032
cellular amine metabolic process GO:0044106 44 0.032
blastocyst development GO:0001824 80 0.031
macromolecule methylation GO:0043414 120 0.031
purine ribonucleoside metabolic process GO:0046128 241 0.031
double strand break repair via homologous recombination GO:0000724 21 0.030
protein modification by small protein removal GO:0070646 21 0.030
respiratory system development GO:0060541 190 0.029
aromatic compound catabolic process GO:0019439 286 0.029
protein localization to nucleus GO:0034504 121 0.029
purine nucleotide catabolic process GO:0006195 211 0.029
cellular response to growth factor stimulus GO:0071363 197 0.029
rna polymerase ii transcriptional preinitiation complex assembly GO:0051123 3 0.027
transcription initiation from rna polymerase ii promoter GO:0006367 8 0.027
positive regulation of protein modification process GO:0031401 299 0.026
cellular hyperosmotic salinity response GO:0071475 0 0.026
neuron projection guidance GO:0097485 141 0.026
regulation of cell cycle process GO:0010564 160 0.026
dna replication GO:0006260 52 0.026
Human Yeast
organic cyclic compound catabolic process GO:1901361 295 0.026
mitotic sister chromatid segregation GO:0000070 14 0.026
macromolecule catabolic process GO:0009057 281 0.026
gene silencing by rna GO:0031047 19 0.025
regulation of cellular amine metabolic process GO:0033238 20 0.025
negative regulation of cell cycle phase transition GO:1901988 48 0.024
deoxyribonucleotide metabolic process GO:0009262 14 0.024
lateral inhibition GO:0046331 1 0.024
organonitrogen compound biosynthetic process GO:1901566 192 0.024
axon guidance GO:0007411 141 0.024
dna methylation GO:0006306 43 0.024
negative regulation of intracellular signal transduction GO:1902532 167 0.024
synapsis GO:0007129 34 0.023
leukocyte migration GO:0050900 124 0.023
ribonucleoside metabolic process GO:0009119 245 0.023
camera type eye development GO:0043010 266 0.023
dna dependent dna replication maintenance of fidelity GO:0045005 3 0.023
regulation of transcription by chromatin organization GO:0034401 0 0.022
negative regulation of organelle assembly GO:1902116 2 0.022
ribonucleoside triphosphate metabolic process GO:0009199 220 0.022
spindle organization GO:0007051 28 0.022
regulation of cellular ketone metabolic process GO:0010565 66 0.022
protein import into nucleus GO:0006606 95 0.022
telencephalon development GO:0021537 186 0.022
organophosphate biosynthetic process GO:0090407 122 0.022
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.022
response to growth factor GO:0070848 198 0.022
lamellipodium organization GO:0097581 29 0.022
positive regulation of intracellular transport GO:0032388 70 0.021
spermatogenesis GO:0007283 284 0.021
stem cell development GO:0048864 219 0.021
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 68 0.021
ameboidal type cell migration GO:0001667 128 0.021
mitotic cell cycle checkpoint GO:0007093 31 0.021
oxidation reduction process GO:0055114 342 0.021
nucleotide metabolic process GO:0009117 332 0.021
myeloid leukocyte migration GO:0097529 57 0.021
regulation of cell cycle GO:0051726 281 0.021
maintenance of protein location in nucleus GO:0051457 2 0.020
nucleoside metabolic process GO:0009116 246 0.020
purine nucleoside metabolic process GO:0042278 241 0.020
gtp catabolic process GO:0006184 143 0.020
nucleotide biosynthetic process GO:0009165 78 0.020
engulfment of apoptotic cell GO:0043652 3 0.020
positive regulation of protein complex assembly GO:0031334 45 0.020
regulation of protein acetylation GO:1901983 22 0.020
negative regulation of mitotic cell cycle phase transition GO:1901991 45 0.020
protein sumoylation GO:0016925 14 0.020
positive regulation of gtpase activity GO:0043547 85 0.019
protein processing GO:0016485 163 0.019
purine nucleoside catabolic process GO:0006152 205 0.019
negative regulation of protein metabolic process GO:0051248 282 0.019
purine ribonucleotide catabolic process GO:0009154 208 0.018
ribonucleoside catabolic process GO:0042454 206 0.018
regulation of response to dna damage stimulus GO:2001020 34 0.018
protein acylation GO:0043543 64 0.018
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.018
nucleoside phosphate catabolic process GO:1901292 222 0.018
regulation of dna damage checkpoint GO:2000001 3 0.018
immune effector process GO:0002252 321 0.018
stem cell differentiation GO:0048863 268 0.018
protein targeting GO:0006605 143 0.018
gonad development GO:0008406 141 0.018
regulation of organelle organization GO:0033043 289 0.017
regulation of cell cycle phase transition GO:1901987 77 0.017
ear development GO:0043583 200 0.017
ribonucleotide metabolic process GO:0009259 291 0.017
regulation of mitotic cell cycle GO:0007346 126 0.017
positive regulation of programmed cell death GO:0043068 218 0.017
positive regulation of intracellular protein transport GO:0090316 42 0.017
regulation of intracellular protein transport GO:0033157 82 0.017
nucleotide excision repair GO:0006289 13 0.017
Human Yeast
dna damage checkpoint GO:0000077 26 0.017
mesenchymal cell differentiation GO:0048762 107 0.017
regulation of cellular response to stress GO:0080135 159 0.017
nucleoside triphosphate catabolic process GO:0009143 205 0.017
dna modification GO:0006304 50 0.017
forebrain development GO:0030900 302 0.016
intraspecies interaction between organisms GO:0051703 21 0.016
organophosphate catabolic process GO:0046434 232 0.016
nucleoside phosphate metabolic process GO:0006753 338 0.016
glycosyl compound metabolic process GO:1901657 246 0.016
gene silencing GO:0016458 38 0.016
regulation of rho gtpase activity GO:0032319 58 0.016
mismatch repair GO:0006298 8 0.016
Human
antimicrobial peptide production GO:0002775 2 0.016
cofactor metabolic process GO:0051186 80 0.016
ribonucleotide catabolic process GO:0009261 208 0.016
internal peptidyl lysine acetylation GO:0018393 42 0.016
purine nucleoside triphosphate catabolic process GO:0009146 203 0.015
cellular response to transforming growth factor beta stimulus GO:0071560 88 0.015
extrinsic apoptotic signaling pathway GO:0097191 126 0.015
regulation of cellular catabolic process GO:0031329 242 0.015
purine nucleoside triphosphate metabolic process GO:0009144 226 0.015
regulation of cytoplasmic transport GO:1903649 112 0.015
negative regulation of cellular protein metabolic process GO:0032269 247 0.015
glial cell differentiation GO:0010001 131 0.015
response to oxidative stress GO:0006979 123 0.015
posttranscriptional regulation of gene expression GO:0010608 155 0.015
regulation of protein complex assembly GO:0043254 83 0.015
cation transport GO:0006812 399 0.015
atp catabolic process GO:0006200 55 0.015
negative regulation of cellular component organization GO:0051129 194 0.014
axonogenesis GO:0007409 274 0.014
mitotic recombination GO:0006312 3 0.014
Yeast
nitrogen compound transport GO:0071705 271 0.014
ribonucleoside monophosphate metabolic process GO:0009161 80 0.014
positive regulation of ras gtpase activity GO:0032320 65 0.014
nucleus organization GO:0006997 45 0.014
negative regulation of chromatin silencing GO:0031936 1 0.014
response to peptide hormone GO:0043434 127 0.013
purine nucleoside monophosphate metabolic process GO:0009126 81 0.013
response to light stimulus GO:0009416 135 0.013
response to acid chemical GO:0001101 111 0.013
regulation of dna binding GO:0051101 39 0.013
organonitrogen compound catabolic process GO:1901565 264 0.013
dna templated transcription termination GO:0006353 4 0.013
spermatid development GO:0007286 108 0.013
ribonucleoside triphosphate catabolic process GO:0009203 199 0.013
leukocyte activation involved in immune response GO:0002366 126 0.013
cellular nitrogen compound catabolic process GO:0044270 280 0.013
positive regulation of nucleocytoplasmic transport GO:0046824 30 0.013
carbohydrate derivative catabolic process GO:1901136 231 0.013
embryonic organ morphogenesis GO:0048562 276 0.013
pyrimidine containing compound metabolic process GO:0072527 11 0.013
purine containing compound catabolic process GO:0072523 213 0.013
translesion synthesis GO:0019985 1 0.013
negative regulation of phosphorylation GO:0042326 166 0.013
lung development GO:0030324 164 0.013
regulation of hormone levels GO:0010817 211 0.013
rna dependent dna replication GO:0006278 3 0.012
Yeast
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.012
regulation of membrane potential GO:0042391 192 0.012
negative regulation of gene expression epigenetic GO:0045814 15 0.012
regulation of peptidyl lysine acetylation GO:2000756 22 0.012
internal protein amino acid acetylation GO:0006475 42 0.012
divalent metal ion transport GO:0070838 172 0.012
cdc42 protein signal transduction GO:0032488 0 0.012
locomotory behavior GO:0007626 195 0.012
regulation of multi organism process GO:0043900 111 0.012
transcription coupled nucleotide excision repair GO:0006283 2 0.012
cation transmembrane transport GO:0098655 266 0.012
positive regulation of gtp catabolic process GO:0033126 85 0.012
regulation of nucleotide catabolic process GO:0030811 122 0.012
rna interference GO:0016246 2 0.012
protein maturation GO:0051604 176 0.012
heterocycle catabolic process GO:0046700 280 0.012
cell cell signaling involved in cell fate commitment GO:0045168 35 0.012
rho protein signal transduction GO:0007266 32 0.011
nucleoside triphosphate metabolic process GO:0009141 230 0.011
social behavior GO:0035176 21 0.011
ribose phosphate metabolic process GO:0019693 291 0.011
peptidyl lysine acetylation GO:0018394 45 0.011
adaptive immune response GO:0002250 155 0.011
cytoplasmic transport GO:0016482 234 0.011
negative regulation of multi organism process GO:0043901 68 0.011
coenzyme metabolic process GO:0006732 52 0.011
regulation of purine nucleotide metabolic process GO:1900542 169 0.011
liver development GO:0001889 66 0.011
regulation of protein transport GO:0051223 163 0.011
mrna transport GO:0051028 13 0.011
response to inorganic substance GO:0010035 96 0.011
negative regulation of wnt signaling pathway GO:0030178 73 0.011
nuclear import GO:0051170 95 0.011
purine ribonucleotide metabolic process GO:0009150 290 0.011
male meiosis chromosome segregation GO:0007060 3 0.011
b cell activation involved in immune response GO:0002312 50 0.011
carbohydrate metabolic process GO:0005975 230 0.011
establishment of protein localization to organelle GO:0072594 118 0.011
divalent inorganic cation transport GO:0072511 178 0.011
digestive system development GO:0055123 200 0.010
regulation of ras gtpase activity GO:0032318 88 0.010
negative regulation of chromosome organization GO:2001251 30 0.010
sulfur compound metabolic process GO:0006790 100 0.010
dna templated transcription initiation GO:0006352 13 0.010
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.010
regulation of cellular component biogenesis GO:0044087 181 0.010
regulation of purine nucleotide catabolic process GO:0033121 122 0.010

Rpa1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
hereditary sensory neuropathy DOID:0050548 0 0.024
peripheral neuropathy DOID:0060053 0 0.024
disease of anatomical entity DOID:7 0 0.024
nervous system disease DOID:863 0 0.024
neuropathy DOID:870 0 0.024
physical disorder DOID:0080015 0 0.022
lissencephaly DOID:0050453 0 0.022
congenital nervous system abnormality DOID:2490 0 0.022