Mus musculus

168 known processes

Runx1

runt related transcription factor 1

(Aliases: Pebp2a2,Pebpa2b,Cbfa2,AI462102,AML1)

Runx1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
negative regulation of myeloid cell differentiation GO:0045638 38 0.997
Human
lymphocyte differentiation GO:0030098 242 0.993
Mouse
regulation of apoptotic signaling pathway GO:2001233 197 0.992
Mouse
myeloid cell differentiation GO:0030099 233 0.984
Human
regulation of chromatin modification GO:1903308 57 0.962
cell fate commitment GO:0045165 210 0.957
Mouse
stem cell development GO:0048864 219 0.943
t cell differentiation GO:0030217 174 0.942
Mouse
histone modification GO:0016570 159 0.932
leukocyte differentiation GO:0002521 342 0.924
Human Mouse
covalent chromatin modification GO:0016569 163 0.924
apoptotic signaling pathway GO:0097190 306 0.919
Mouse
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.917
Mouse
t cell differentiation in thymus GO:0033077 77 0.913
peptidyl lysine modification GO:0018205 77 0.910
negative regulation of immune system process GO:0002683 209 0.898
Human
regulation of myeloid cell differentiation GO:0045637 96 0.896
Human
regulation of histone modification GO:0031056 56 0.892
chromatin modification GO:0016568 187 0.886
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 45 0.882
leukocyte activation involved in immune response GO:0002366 126 0.881
regionalization GO:0003002 337 0.880
regulation of leukocyte differentiation GO:1902105 159 0.876
Human
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.869
blood vessel morphogenesis GO:0048514 285 0.866
macromolecule methylation GO:0043414 120 0.866
myeloid leukocyte activation GO:0002274 83 0.864
regulation of cellular amino acid metabolic process GO:0006521 5 0.860
negative regulation of myeloid leukocyte differentiation GO:0002762 20 0.856
Human
axon guidance GO:0007411 141 0.855
Mouse Fly
t helper cell differentiation GO:0042093 28 0.853
positive regulation of t cell differentiation GO:0045582 52 0.849
response to radiation GO:0009314 165 0.845
chromatin organization GO:0006325 206 0.838
positive regulation of leukocyte differentiation GO:1902107 86 0.838
Human
regulation of t cell differentiation GO:0045580 83 0.831
regulation of chromosome organization GO:0033044 83 0.827
alpha beta t cell differentiation GO:0046632 69 0.826
cd4 positive alpha beta t cell activation GO:0035710 45 0.822
response to ionizing radiation GO:0010212 42 0.811
regulation of chromatin organization GO:1902275 57 0.808
cytokine biosynthetic process GO:0042089 68 0.805
histone acetylation GO:0016573 41 0.795
macrophage differentiation GO:0030225 20 0.795
t cell activation involved in immune response GO:0002286 43 0.786
embryonic organ morphogenesis GO:0048562 276 0.774
Mouse
hematopoietic progenitor cell differentiation GO:0002244 143 0.761
regulation of epithelial cell proliferation GO:0050678 141 0.754
Mouse
b cell activation GO:0042113 161 0.749
negative regulation of apoptotic signaling pathway GO:2001234 104 0.748
stem cell maintenance GO:0019827 130 0.746
regulation of lymphocyte differentiation GO:0045619 107 0.744
regulation of cellular amine metabolic process GO:0033238 20 0.741
homeostasis of number of cells GO:0048872 210 0.735
positive regulation of stem cell differentiation GO:2000738 23 0.734
dna methylation GO:0006306 43 0.730
immune response activating signal transduction GO:0002757 116 0.725
regulation of stem cell differentiation GO:2000736 50 0.717
cd4 positive alpha beta t cell differentiation GO:0043367 41 0.707
dna metabolic process GO:0006259 303 0.701
myeloid cell homeostasis GO:0002262 114 0.687
amine metabolic process GO:0009308 45 0.685
antigen receptor mediated signaling pathway GO:0050851 64 0.682
methylation GO:0032259 134 0.671
t cell activation GO:0042110 289 0.669
Mouse
regulation of cd4 positive alpha beta t cell activation GO:2000514 24 0.664
lymphocyte activation involved in immune response GO:0002285 93 0.664
gland development GO:0048732 330 0.662
protein acylation GO:0043543 64 0.658
positive regulation of protein modification process GO:0031401 299 0.647
mesenchyme development GO:0060485 152 0.643
regulation of cell activation GO:0050865 289 0.636
regulation of alpha beta t cell differentiation GO:0046637 35 0.630
cd4 positive alpha beta t cell differentiation involved in immune response GO:0002294 28 0.629
positive regulation of lymphocyte activation GO:0051251 140 0.628
cellular amine metabolic process GO:0044106 44 0.625
neutrophil differentiation GO:0030223 3 0.621
regulation of t cell activation GO:0050863 170 0.610
morphogenesis of a branching epithelium GO:0061138 193 0.610
t cell differentiation involved in immune response GO:0002292 30 0.586
positive regulation of cell development GO:0010720 237 0.580
Fly
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 68 0.578
wound healing GO:0042060 157 0.575
Fly
regulation of transferase activity GO:0051338 263 0.559
negative regulation of cell proliferation GO:0008285 296 0.551
Mouse
alpha beta t cell differentiation involved in immune response GO:0002293 30 0.540
immune response activating cell surface receptor signaling pathway GO:0002429 72 0.539
regulation of cytokine biosynthetic process GO:0042035 59 0.539
regulation of neutrophil differentiation GO:0045658 2 0.530
hematopoietic stem cell migration GO:0035701 1 0.526
positive regulation of t cell activation GO:0050870 101 0.523
cell activation involved in immune response GO:0002263 126 0.522
muscle system process GO:0003012 141 0.517
megakaryocyte differentiation GO:0030219 26 0.515
epithelial tube morphogenesis GO:0060562 303 0.506
regulation of erythrocyte differentiation GO:0045646 23 0.501
alpha beta t cell activation GO:0046631 91 0.498
angiogenesis GO:0001525 201 0.496
dna recombination GO:0006310 92 0.484
cellular response to lipid GO:0071396 145 0.474
extrinsic apoptotic signaling pathway GO:0097191 126 0.450
Mouse
regulation of neuron differentiation GO:0045664 281 0.449
regulation of cytokine production GO:0001817 266 0.443
positive regulation of glial cell proliferation GO:0060252 4 0.442
regulation of cd4 positive alpha beta t cell differentiation GO:0043370 21 0.438
peptidyl amino acid modification GO:0018193 336 0.436
positive regulation of cell activation GO:0050867 158 0.426
negative regulation of protein metabolic process GO:0051248 282 0.422
myeloid leukocyte differentiation GO:0002573 119 0.421
Human
regulation of organ morphogenesis GO:2000027 144 0.409
Mouse Fly
histone lysine methylation GO:0034968 50 0.407
negative regulation of blood vessel endothelial cell migration GO:0043537 3 0.405
negative regulation of molecular function GO:0044092 258 0.399
cytokine mediated signaling pathway GO:0019221 115 0.398
regulation of cell cycle GO:0051726 281 0.392
Mouse
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 55 0.385
somatic stem cell maintenance GO:0035019 47 0.385
internal protein amino acid acetylation GO:0006475 42 0.382
cellular response to gamma radiation GO:0071480 4 0.377
regulation of cellular ketone metabolic process GO:0010565 66 0.375
regulation of kinase activity GO:0043549 249 0.373
positive regulation of lymphocyte differentiation GO:0045621 61 0.372
positive regulation of leukocyte proliferation GO:0070665 73 0.371
negative regulation of fat cell differentiation GO:0045599 36 0.362
regulation of myeloid leukocyte differentiation GO:0002761 58 0.362
Human
positive regulation of cell cycle GO:0045787 92 0.361
erythrocyte differentiation GO:0030218 88 0.361
response to retinoic acid GO:0032526 56 0.353
positive regulation of cell death GO:0010942 224 0.352
Mouse Fly
developmental maturation GO:0021700 193 0.352
Mouse
carbohydrate derivative biosynthetic process GO:1901137 183 0.351
connective tissue development GO:0061448 179 0.348
Mouse
male gamete generation GO:0048232 285 0.345
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.341
morphogenesis of a branching structure GO:0001763 203 0.338
leukocyte proliferation GO:0070661 172 0.338
cellular amino acid metabolic process GO:0006520 103 0.334
negative regulation of cellular amine metabolic process GO:0033239 1 0.332
multicellular organism growth GO:0035264 161 0.331
Worm
negative regulation of protein modification process GO:0031400 163 0.329
protein methylation GO:0006479 81 0.328
muscle cell differentiation GO:0042692 261 0.326
regulation of histone h3 k4 methylation GO:0051569 12 0.323
divalent metal ion transport GO:0070838 172 0.323
positive regulation of kinase activity GO:0033674 155 0.321
gastrulation GO:0007369 116 0.316
Fly
cellular ketone metabolic process GO:0042180 84 0.312
alpha beta t cell activation involved in immune response GO:0002287 31 0.310
regulation of interferon gamma production GO:0032649 57 0.306
regulation of fat cell differentiation GO:0045598 81 0.305
b cell differentiation GO:0030183 78 0.301
t cell proliferation GO:0042098 120 0.296
dna alkylation GO:0006305 43 0.295
glycoprotein biosynthetic process GO:0009101 89 0.286
calcium ion transport GO:0006816 159 0.281
negative regulation of homeostatic process GO:0032845 71 0.280
cellular response to cytokine stimulus GO:0071345 189 0.278
body morphogenesis GO:0010171 45 0.278
cytokine secretion GO:0050663 72 0.273
peptidyl lysine acetylation GO:0018394 45 0.267
muscle tissue development GO:0060537 308 0.267
regulation of lymphocyte proliferation GO:0050670 117 0.266
positive regulation of osteoclast differentiation GO:0045672 15 0.266
ossification GO:0001503 216 0.263
Mouse
metanephros development GO:0001656 79 0.262
regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001239 26 0.256
placenta development GO:0001890 140 0.255
epithelial cell proliferation GO:0050673 174 0.250
Mouse
response to oxidative stress GO:0006979 123 0.250
keratinocyte differentiation GO:0030216 48 0.245
microtubule based process GO:0007017 236 0.239
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.233
Mouse
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902043 13 0.231
cellular response to ethanol GO:0071361 3 0.229
regulation of histone acetylation GO:0035065 19 0.229
regulation of stress activated mapk cascade GO:0032872 69 0.228
regulation of tumor necrosis factor production GO:0032680 49 0.225
branching morphogenesis of an epithelial tube GO:0048754 159 0.224
positive regulation of angiogenesis GO:0045766 46 0.223
positive regulation of reactive oxygen species metabolic process GO:2000379 11 0.222
positive regulation of b cell proliferation GO:0030890 24 0.221
response to lipopolysaccharide GO:0032496 128 0.219
negative regulation of intracellular signal transduction GO:1902532 167 0.219
regulation of histone methylation GO:0031060 30 0.219
extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 34 0.218
regulation of homeostatic process GO:0032844 182 0.218
organ growth GO:0035265 117 0.218
cellular response to lipopolysaccharide GO:0071222 77 0.217
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 57 0.217
response to acid chemical GO:0001101 111 0.216
skeletal system morphogenesis GO:0048705 203 0.215
Mouse
multi multicellular organism process GO:0044706 109 0.214
positive regulation of mapk cascade GO:0043410 170 0.212
cytokine production GO:0001816 319 0.211
Mouse
cellular response to transforming growth factor beta stimulus GO:0071560 88 0.211
negative regulation of map kinase activity GO:0043407 34 0.208
signal transduction in absence of ligand GO:0038034 55 0.206
adaptive immune response GO:0002250 155 0.204
embryonic placenta development GO:0001892 98 0.202
negative regulation of kinase activity GO:0033673 81 0.201
reactive oxygen species metabolic process GO:0072593 84 0.199
production of molecular mediator of immune response GO:0002440 103 0.199
jnk cascade GO:0007254 72 0.199
renal system development GO:0072001 225 0.199
defense response to bacterium GO:0042742 119 0.198
histone h3 k4 methylation GO:0051568 23 0.196
regulation of map kinase activity GO:0043405 120 0.195
positive regulation of chromosome organization GO:2001252 33 0.194
positive regulation of histone modification GO:0031058 28 0.193
glial cell apoptotic process GO:0034349 3 0.192
positive regulation of growth GO:0045927 104 0.191
Worm
cardiocyte differentiation GO:0035051 87 0.191
membrane organization GO:0061024 245 0.190
protein secretion GO:0009306 111 0.189
hypermethylation of cpg island GO:0044027 3 0.188
cellular component assembly involved in morphogenesis GO:0010927 139 0.186
skeletal system development GO:0001501 356 0.184
immune response regulating signaling pathway GO:0002764 125 0.184
myeloid leukocyte migration GO:0097529 57 0.182
protein kinase b signaling GO:0043491 74 0.181
digestive tract development GO:0048565 190 0.179
Fly
cell cycle g1 s phase transition GO:0044843 57 0.178
lymphocyte mediated immunity GO:0002449 139 0.178
divalent inorganic cation transport GO:0072511 178 0.178
cellular response to biotic stimulus GO:0071216 92 0.176
histone h3 acetylation GO:0043966 14 0.174
eosinophil activation involved in immune response GO:0002278 1 0.173
t cell receptor signaling pathway GO:0050852 46 0.172
cell fate specification GO:0001708 72 0.172
internal peptidyl lysine acetylation GO:0018393 42 0.169
regulation of lymphocyte activation GO:0051249 240 0.168
gliogenesis GO:0042063 141 0.167
germ cell development GO:0007281 185 0.166
positive regulation of cytokine production GO:0001819 174 0.166
regulation of osteoclast differentiation GO:0045670 36 0.165
regulation of mitotic cell cycle phase transition GO:1901990 73 0.163
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.162
fat cell differentiation GO:0045444 160 0.162
apoptotic process involved in morphogenesis GO:0060561 25 0.162
response to growth factor GO:0070848 198 0.161
tumor necrosis factor superfamily cytokine production GO:0071706 51 0.160
regulation of hydrolase activity GO:0051336 246 0.160
axonogenesis GO:0007409 274 0.154
Mouse Fly
cellular chemical homeostasis GO:0055082 215 0.154
negative regulation of cellular protein metabolic process GO:0032269 247 0.153
g protein coupled receptor signaling pathway GO:0007186 243 0.152
positive regulation of protein kinase activity GO:0045860 144 0.152
appendage morphogenesis GO:0035107 149 0.152
Mouse
regulation of peptidyl lysine acetylation GO:2000756 22 0.152
leukocyte apoptotic process GO:0071887 71 0.152
nephron tubule development GO:0072080 84 0.151
regulation of cell cycle process GO:0010564 160 0.151
v d j recombination GO:0033151 14 0.150
negative regulation of protein maturation GO:1903318 79 0.149
wnt signaling pathway GO:0016055 188 0.149
inflammatory response GO:0006954 244 0.148
signal transduction involved in dna integrity checkpoint GO:0072401 3 0.148
cellular response to radiation GO:0071478 28 0.148
macromolecule deacylation GO:0098732 37 0.147
regulation of dna methylation GO:0044030 12 0.146
protein ubiquitination GO:0016567 171 0.144
protein modification by small protein conjugation GO:0032446 187 0.144
negative regulation of leukocyte differentiation GO:1902106 51 0.144
Human
myeloid dendritic cell activation GO:0001773 25 0.143
regulation of b cell activation GO:0050864 81 0.143
somatic cell dna recombination GO:0016444 51 0.143
mitotic g1 dna damage checkpoint GO:0031571 4 0.141
protein catabolic process GO:0030163 221 0.141
signal transduction involved in dna damage checkpoint GO:0072422 3 0.141
regulation of granulocyte differentiation GO:0030852 8 0.140
Human
response to calcium ion GO:0051592 20 0.140
humoral immune response GO:0006959 57 0.140
myeloid dendritic cell differentiation GO:0043011 16 0.140
muscle cell development GO:0055001 133 0.139
positive regulation of nervous system development GO:0051962 221 0.138
positive regulation of gliogenesis GO:0014015 27 0.137
regulation of binding GO:0051098 111 0.137
regulation of intracellular protein transport GO:0033157 82 0.137
protein localization to nucleus GO:0034504 121 0.136
dna modification GO:0006304 50 0.136
response to metal ion GO:0010038 47 0.133
regulation of defense response to bacterium GO:1900424 3 0.133
regulation of alpha beta t cell activation GO:0046634 53 0.133
positive regulation of lymphocyte mediated immunity GO:0002708 62 0.132
response to organonitrogen compound GO:0010243 246 0.131
positive regulation of neuron differentiation GO:0045666 141 0.131
epithelial to mesenchymal transition GO:0001837 47 0.130
neural precursor cell proliferation GO:0061351 121 0.129
regulation of endopeptidase activity GO:0052548 89 0.129
cellular response to dna damage stimulus GO:0006974 207 0.127
signal transduction involved in cell cycle checkpoint GO:0072395 3 0.127
posttranscriptional regulation of gene expression GO:0010608 155 0.127
fibroblast proliferation GO:0048144 35 0.127
positive regulation of map kinase activity GO:0043406 84 0.127
thymic t cell selection GO:0045061 22 0.126
limb development GO:0060173 166 0.126
Mouse
signal transduction involved in mitotic dna damage checkpoint GO:1902402 3 0.125
regulation of cell motility GO:2000145 236 0.124
ear development GO:0043583 200 0.123
response to organic cyclic compound GO:0014070 198 0.122
positive regulation of cytokine biosynthetic process GO:0042108 40 0.121
negative regulation of adaptive immune response GO:0002820 25 0.121
stem cell differentiation GO:0048863 268 0.120
Mouse
macromolecule catabolic process GO:0009057 281 0.120
cellular senescence GO:0090398 11 0.120
renal tubule development GO:0061326 87 0.119
positive regulation of organelle organization GO:0010638 128 0.119
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.119
positive regulation of programmed cell death GO:0043068 218 0.118
Mouse Fly
regulation of megakaryocyte differentiation GO:0045652 7 0.118
positive regulation of transcription from rna polymerase ii promoter involved in smooth muscle cell differentiation GO:2000721 2 0.118
cation transport GO:0006812 399 0.117
odontogenesis GO:0042476 78 0.117
Mouse
segmentation GO:0035282 93 0.117
innate immune response activating signal transduction GO:0002758 50 0.116
regulation of gliogenesis GO:0014013 50 0.116
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 11 0.116
positive regulation of epithelial cell proliferation GO:0050679 68 0.115
negative regulation of protein serine threonine kinase activity GO:0071901 49 0.114
chemotaxis GO:0006935 247 0.114
Mouse Fly
megakaryocyte development GO:0035855 15 0.114
antibacterial peptide biosynthetic process GO:0002780 2 0.114
somatic diversification of immunoglobulins involved in immune response GO:0002208 36 0.114
muscle adaptation GO:0043500 39 0.113
positive regulation of keratinocyte differentiation GO:0045618 3 0.113
regulation of angiogenesis GO:0045765 81 0.112
regulation of transforming growth factor beta receptor signaling pathway GO:0017015 43 0.112
negative regulation of protein processing GO:0010955 79 0.111
regulation of secretion GO:0051046 274 0.111
cellular response to antibiotic GO:0071236 4 0.110
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.109
cellular response to follicle stimulating hormone stimulus GO:0071372 1 0.109
g1 s transition of mitotic cell cycle GO:0000082 57 0.109
bmp signaling pathway GO:0030509 93 0.109
Mouse
negative regulation of blood vessel morphogenesis GO:2000181 25 0.108
regulation of secretion by cell GO:1903530 249 0.107
striated muscle cell development GO:0055002 125 0.107
regulation of osteoblast differentiation GO:0045667 67 0.107
Mouse
dna damage response signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 3 0.107
regulation of interleukin 6 production GO:0032675 55 0.107
positive regulation of immature t cell proliferation GO:0033091 4 0.106
dendritic cell differentiation GO:0097028 26 0.106
cellular response to external stimulus GO:0071496 88 0.106
regulation of t cell proliferation GO:0042129 92 0.105
negative regulation of hematopoietic progenitor cell differentiation GO:1901533 4 0.104
cartilage development GO:0051216 140 0.104
Mouse
embryonic hemopoiesis GO:0035162 23 0.103
reactive nitrogen species metabolic process GO:2001057 0 0.102
positive regulation of antibacterial peptide biosynthetic process GO:0006963 1 0.102
negative regulation of odontogenesis GO:0042483 3 0.102
regulation of hematopoietic progenitor cell differentiation GO:1901532 18 0.101
regulation of innate immune response GO:0045088 91 0.101
epithelial cell differentiation involved in kidney development GO:0035850 23 0.100
engulfment of apoptotic cell GO:0043652 3 0.100
sarcomere organization GO:0045214 24 0.100
cardiac right ventricle formation GO:0003219 3 0.099
kidney development GO:0001822 213 0.099
negative regulation of granulocyte differentiation GO:0030853 3 0.099
Human
b cell mediated immunity GO:0019724 71 0.099
negative regulation of chromatin modification GO:1903309 19 0.099
transmembrane transport GO:0055085 412 0.099
regulation of reactive oxygen species metabolic process GO:2000377 40 0.098
regulation of response to wounding GO:1903034 189 0.098
regulation of organelle organization GO:0033043 289 0.098
cellular calcium ion homeostasis GO:0006874 119 0.098
regulation of cellular response to stress GO:0080135 159 0.098
positive regulation of innate immune response GO:0045089 80 0.098
branching involved in mammary gland duct morphogenesis GO:0060444 27 0.097
cellular response to inorganic substance GO:0071241 37 0.097
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.096
Mouse
regulation of cell division GO:0051302 76 0.096
regulation of neuron projection development GO:0010975 169 0.095
regulation of protein kinase activity GO:0045859 232 0.095
response to molecule of bacterial origin GO:0002237 143 0.095
dna hypermethylation GO:0044026 3 0.095
regulation of endothelial cell chemotaxis GO:2001026 1 0.095
histone methylation GO:0016571 71 0.094
osteoclast differentiation GO:0030316 62 0.094
canonical wnt signaling pathway GO:0060070 130 0.094
regulation of peptidyl tyrosine phosphorylation GO:0050730 93 0.093
protein modification by small protein conjugation or removal GO:0070647 207 0.093
positive regulation of proteolysis GO:0045862 85 0.093
positive regulation of alpha beta t cell differentiation GO:0046638 28 0.092
mesenchymal cell differentiation GO:0048762 107 0.092
cell adhesion GO:0007155 329 0.092
negative regulation of inflammatory response GO:0050728 61 0.092
response to peptide GO:1901652 136 0.091
positive regulation of alpha beta t cell activation GO:0046635 39 0.091
regulation of antibacterial peptide production GO:0002786 1 0.090
positive regulation of epithelial to mesenchymal transition GO:0010718 13 0.090
regulation of ion transport GO:0043269 215 0.090
proteasomal protein catabolic process GO:0010498 98 0.090
response to drug GO:0042493 75 0.089
regulation of leukocyte mediated immunity GO:0002703 104 0.088
regulation of membrane potential GO:0042391 192 0.087
regulation of tumor necrosis factor superfamily cytokine production GO:1903555 50 0.087
regulation of glial cell differentiation GO:0045685 41 0.087
microglia development GO:0014005 2 0.087
protein alkylation GO:0008213 81 0.087
positive regulation of production of molecular mediator of immune response GO:0002702 45 0.086
regulation of translation GO:0006417 71 0.086
glycoprotein metabolic process GO:0009100 116 0.085
epidermis development GO:0008544 187 0.085
thymus development GO:0048538 41 0.085
cellular response to starvation GO:0009267 57 0.085
face morphogenesis GO:0060325 29 0.084
positive regulation of mitotic cell cycle GO:0045931 41 0.083
positive regulation of cell cycle process GO:0090068 61 0.083
striated muscle tissue development GO:0014706 293 0.082
negative regulation of cytokine production GO:0001818 84 0.082
negative regulation of interferon gamma production GO:0032689 18 0.082
regulation of stem cell proliferation GO:0072091 78 0.081
histone h4 acetylation GO:0043967 10 0.080
negative regulation of cyclin dependent protein serine threonine kinase activity GO:0045736 9 0.080
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 16 0.079
regulation of protein maturation GO:1903317 96 0.079
mammary gland epithelium development GO:0061180 65 0.079
natural killer cell activation GO:0030101 44 0.079
organonitrogen compound biosynthetic process GO:1901566 192 0.079
cellular response to gonadotropin stimulus GO:0071371 4 0.079
regulation of peptidase activity GO:0052547 96 0.078
positive regulation of myeloid cell differentiation GO:0045639 43 0.078
Human
intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 35 0.077
regulation of ossification GO:0030278 112 0.077
Mouse
regulation of cell migration GO:0030334 219 0.077
regulation of chemokine production GO:0032642 30 0.077
regulation of protein serine threonine kinase activity GO:0071900 157 0.077
calcium ion homeostasis GO:0055074 127 0.077
t cell selection GO:0045058 34 0.077
negative regulation of phosphorylation GO:0042326 166 0.076
negative regulation of histone modification GO:0031057 18 0.076
t cell migration GO:0072678 19 0.076
bone morphogenesis GO:0060349 78 0.075
Mouse
single organismal cell cell adhesion GO:0016337 131 0.075
negative regulation of mammary gland epithelial cell proliferation GO:0033600 3 0.075
lens development in camera type eye GO:0002088 62 0.074
cellular response to tumor necrosis factor GO:0071356 21 0.074
negative regulation of ossification GO:0030279 49 0.074
sensory perception of sound GO:0007605 97 0.073
negative regulation of transferase activity GO:0051348 85 0.073
compound eye development GO:0048749 1 0.073
Fly
modification dependent macromolecule catabolic process GO:0043632 133 0.073
actomyosin structure organization GO:0031032 56 0.073
transforming growth factor beta receptor signaling pathway GO:0007179 71 0.073
action potential GO:0001508 78 0.072
cellular response to growth factor stimulus GO:0071363 197 0.072
positive regulation of jnk cascade GO:0046330 46 0.072
hair cycle GO:0042633 90 0.072
organelle assembly GO:0070925 177 0.072
somatic diversification of immunoglobulins GO:0016445 43 0.072
antimicrobial peptide biosynthetic process GO:0002777 2 0.072
regulation of cysteine type endopeptidase activity GO:2000116 65 0.071
t helper 1 cell differentiation GO:0045063 13 0.071
regulation of glycoprotein biosynthetic process GO:0010559 12 0.071
cellular response to extracellular stimulus GO:0031668 81 0.070
second messenger mediated signaling GO:0019932 73 0.070
cell aging GO:0007569 35 0.070
somatic diversification of immune receptors GO:0002200 53 0.069
neuronal action potential GO:0019228 54 0.069
leukocyte cell cell adhesion GO:0007159 14 0.069
ear morphogenesis GO:0042471 118 0.069
leukocyte migration GO:0050900 124 0.069
negative regulation of endothelial cell migration GO:0010596 4 0.069
cellular response to drug GO:0035690 15 0.069
cellular amide metabolic process GO:0043603 58 0.069
negative regulation of calcium ion dependent exocytosis GO:0045955 3 0.069
synapse organization GO:0050808 125 0.068
gonad development GO:0008406 141 0.068
positive regulation of chromatin modification GO:1903310 28 0.067
negative regulation of synaptic vesicle exocytosis GO:2000301 3 0.067
positive regulation of hematopoietic stem cell migration GO:2000473 1 0.067
chromatin remodeling GO:0006338 32 0.067
neuron apoptotic process GO:0051402 142 0.067
regulation of cardiac muscle cell proliferation GO:0060043 23 0.067
carbohydrate metabolic process GO:0005975 230 0.067
central nervous system neuron differentiation GO:0021953 162 0.067
response to endoplasmic reticulum stress GO:0034976 53 0.066
defense response to virus GO:0051607 68 0.066
regulation of cardioblast differentiation GO:0051890 3 0.066
somatic recombination of immunoglobulin gene segments GO:0016447 42 0.065
peptide metabolic process GO:0006518 46 0.065
positive regulation of antimicrobial peptide production GO:0002225 1 0.065
negative regulation of angiogenesis GO:0016525 25 0.064
defense response to other organism GO:0098542 197 0.064
calcium mediated signaling GO:0019722 46 0.064
biomineral tissue development GO:0031214 64 0.064
regulation of intrinsic apoptotic signaling pathway GO:2001242 61 0.064
regulation of tumor necrosis factor biosynthetic process GO:0042534 10 0.064
negative regulation of chromosome organization GO:2001251 30 0.063
positive regulation of apoptotic signaling pathway GO:2001235 95 0.063
Mouse
cellular response to interleukin 4 GO:0071353 21 0.063
response to extracellular stimulus GO:0009991 127 0.063
regulation of ion homeostasis GO:2000021 64 0.063
lymphocyte proliferation GO:0046651 164 0.063
multicellular organismal homeostasis GO:0048871 164 0.062
positive regulation of apoptotic process involved in mammary gland involution GO:0060058 4 0.062

Runx1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 0 0.424
Human
cancer DOID:162 0 0.167
Human
organ system cancer DOID:0050686 0 0.167
Human