Mus musculus

207 known processes

Runx2

runt related transcription factor 2

(Aliases: Osf2,Cbfa-1,AML3,Cbfa1,Pebp2a1,Pebpa2a,LS3,Cbf,PEBP2aA)

Runx2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
skeletal system morphogenesis GO:0048705 203 1.000
embryonic skeletal system morphogenesis GO:0048704 91 1.000
embryonic skeletal system development GO:0048706 120 0.999
retinal bipolar neuron differentiation GO:0060040 5 0.999
stem cell development GO:0048864 219 0.998
neural crest cell migration involved in autonomic nervous system development GO:1901166 5 0.997
limb development GO:0060173 166 0.996
embryonic organ morphogenesis GO:0048562 276 0.995
skeletal system development GO:0001501 356 0.993
osteoblast development GO:0002076 17 0.990
sensory organ morphogenesis GO:0090596 242 0.989
Fly
bone morphogenesis GO:0060349 78 0.989
globus pallidus development GO:0021759 2 0.989
epithelial to mesenchymal transition GO:0001837 47 0.987
embryonic olfactory bulb interneuron precursor migration GO:0021831 2 0.986
nodal signaling pathway involved in determination of left right asymmetry GO:0038107 2 0.984
cell proliferation involved in outflow tract morphogenesis GO:0061325 4 0.982
mesenchymal cell development GO:0014031 93 0.982
limb morphogenesis GO:0035108 149 0.981
chondrocyte differentiation GO:0002062 72 0.981
appendage morphogenesis GO:0035107 149 0.980
chondrocyte development GO:0002063 24 0.979
mammary placode formation GO:0060596 4 0.975
regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis GO:0072039 4 0.974
carbon catabolite repression of transcription from rna polymerase ii promoter GO:0000437 1 0.972
mesenchymal cell differentiation GO:0048762 107 0.971
mesenchyme development GO:0060485 152 0.971
blood vessel morphogenesis GO:0048514 285 0.970
Mouse
endochondral bone morphogenesis GO:0060350 50 0.962
myeloid cell differentiation GO:0030099 233 0.962
positive regulation of inner ear receptor cell differentiation GO:2000982 1 0.961
endodermal cell fate specification GO:0001714 4 0.960
embryonic appendage morphogenesis GO:0035113 126 0.960
nodal signaling pathway involved in determination of lateral mesoderm left right asymmetry GO:1900164 2 0.955
positive regulation of stem cell proliferation GO:2000648 59 0.953
embryonic limb morphogenesis GO:0030326 126 0.952
replacement ossification GO:0036075 26 0.950
regulation of transcription from rna polymerase ii promoter involved in determination of left right symmetry GO:1900094 2 0.950
embryonic skeletal joint development GO:0072498 13 0.948
tooth mineralization GO:0034505 9 0.945
epithelial tube morphogenesis GO:0060562 303 0.943
positive regulation of cell motility GO:2000147 116 0.943
embryonic camera type eye development GO:0031076 36 0.942
stem cell differentiation GO:0048863 268 0.941
embryonic skeletal joint morphogenesis GO:0060272 11 0.940
positive regulation of ossification GO:0045778 47 0.938
negative regulation of epithelial cell proliferation GO:0050680 64 0.937
Mouse
regulation of cell motility GO:2000145 236 0.935
positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation GO:2000802 1 0.933
forelimb morphogenesis GO:0035136 40 0.932
regionalization GO:0003002 337 0.931
Zebrafish
ossification GO:0001503 216 0.931
digestive tract development GO:0048565 190 0.931
Fly
regulation of osteoblast differentiation GO:0045667 67 0.929
forebrain generation of neurons GO:0021872 63 0.924
positive regulation of apoptotic process GO:0043065 217 0.924
Mouse
myeloid leukocyte differentiation GO:0002573 119 0.920
embryonic digit morphogenesis GO:0042733 56 0.919
diencephalon development GO:0021536 63 0.917
central nervous system neuron differentiation GO:0021953 162 0.914
cellular response to growth factor stimulus GO:0071363 197 0.914
telencephalon cell migration GO:0022029 55 0.912
forebrain cell migration GO:0021885 58 0.907
melanocyte differentiation GO:0030318 25 0.906
regulation of skeletal muscle fiber development GO:0048742 36 0.903
positive regulation of auditory receptor cell differentiation GO:0045609 1 0.902
regulation of stem cell differentiation GO:2000736 50 0.899
tangential migration from the subventricular zone to the olfactory bulb GO:0022028 5 0.896
mesenchymal cell proliferation involved in ureter development GO:0072198 4 0.895
muscle cell development GO:0055001 133 0.894
embryonic heart tube formation GO:0003144 1 0.891
neural crest formation GO:0014029 2 0.889
positive regulation of transcription from rna polymerase ii promoter involved in cellular response to chemical stimulus GO:1901522 7 0.889
palate development GO:0060021 76 0.884
bmp signaling pathway GO:0030509 93 0.882
positive regulation of osteoblast differentiation GO:0045669 34 0.881
aorta morphogenesis GO:0035909 22 0.881
hindlimb morphogenesis GO:0035137 42 0.878
regulation of odontogenesis GO:0042481 18 0.877
cartilage development involved in endochondral bone morphogenesis GO:0060351 24 0.876
endodermal cell fate commitment GO:0001711 12 0.876
forebrain development GO:0030900 302 0.876
regulation of leukocyte differentiation GO:1902105 159 0.875
connective tissue development GO:0061448 179 0.873
apoptotic process involved in outflow tract morphogenesis GO:0003275 2 0.871
regulation of mesenchymal cell proliferation involved in ureter development GO:0072199 3 0.866
camera type eye development GO:0043010 266 0.866
carbon catabolite activation of transcription from rna polymerase ii promoter GO:0000436 4 0.865
regulation of myoblast differentiation GO:0045661 29 0.861
mesonephros development GO:0001823 97 0.858
cerebral cortex gabaergic interneuron differentiation GO:0021892 9 0.857
positive regulation of transcription from rna polymerase ii promoter involved in myocardial precursor cell differentiation GO:0003257 3 0.849
positive regulation of phospholipase activity GO:0010518 3 0.848
mesenchymal cell apoptotic process involved in nephron morphogenesis GO:1901145 4 0.843
auditory receptor cell fate determination GO:0042668 3 0.840
neural tube closure GO:0001843 90 0.838
leukocyte differentiation GO:0002521 342 0.836
neuron projection guidance GO:0097485 141 0.834
Mouse Fly
positive regulation of epithelial to mesenchymal transition GO:0010718 13 0.834
regulation of ossification GO:0030278 112 0.818
positive regulation of transcription from rna polymerase ii promoter involved in norepinephrine biosynthetic process GO:2000763 1 0.812
tendon cell differentiation GO:0035990 4 0.811
stem cell maintenance GO:0019827 130 0.810
cerebral cortex neuron differentiation GO:0021895 19 0.810
negative regulation of muscle cell differentiation GO:0051148 33 0.808
ventricular zone neuroblast division GO:0021847 3 0.807
negative regulation of planar cell polarity pathway involved in pericardium morphogenesis GO:2000166 1 0.807
smoothened signaling pathway involved in dorsal ventral neural tube patterning GO:0060831 12 0.805
regulation of chondrocyte differentiation GO:0032330 33 0.800
bmp signaling pathway involved in heart development GO:0061312 2 0.797
regulation of cell cycle GO:0051726 281 0.796
Mouse
odontogenesis GO:0042476 78 0.793
skeletal muscle organ development GO:0060538 163 0.792
neural crest cell migration GO:0001755 32 0.791
positive regulation of epithelial cell proliferation GO:0050679 68 0.790
developmental maturation GO:0021700 193 0.790
deltoid tuberosity development GO:0035993 3 0.786
cerebral cortex gabaergic interneuron migration GO:0021853 6 0.784
positive regulation of epithelial cell proliferation involved in lung morphogenesis GO:0060501 3 0.778
embryonic hindlimb morphogenesis GO:0035116 32 0.774
regulation of epithelial to mesenchymal transition GO:0010717 22 0.769
sensory perception of light stimulus GO:0050953 54 0.768
planar cell polarity pathway involved in cardiac muscle tissue morphogenesis GO:0061350 2 0.762
embryonic nail plate morphogenesis GO:0035880 3 0.761
digestive system development GO:0055123 200 0.758
Fly
trachea formation GO:0060440 3 0.754
sinoatrial node cell differentiation GO:0060921 3 0.754
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.752
pigmentation GO:0043473 71 0.751
positive regulation of secondary heart field cardioblast proliferation GO:0072513 4 0.748
telencephalon development GO:0021537 186 0.746
primary neural tube formation GO:0014020 95 0.745
otic placode formation GO:0043049 1 0.743
positive regulation of transcription from rna polymerase ii promoter by glucose GO:0000432 3 0.742
response to growth factor GO:0070848 198 0.741
cell proliferation in hindbrain GO:0021534 10 0.740
positive regulation of mesenchymal cell proliferation involved in ureter development GO:2000729 3 0.738
response to acid chemical GO:0001101 111 0.738
Mouse
regulation of planar cell polarity pathway involved in ventricular septum morphogenesis GO:2000148 1 0.737
regulation of endodermal cell fate specification GO:0042663 2 0.735
left lung development GO:0060459 4 0.734
regulation of fat cell differentiation GO:0045598 81 0.731
hindbrain tangential cell migration GO:0021934 2 0.729
neural crest cell differentiation GO:0014033 54 0.727
his purkinje system cell differentiation GO:0060932 2 0.726
biomineral tissue development GO:0031214 64 0.724
epithelial cell development GO:0002064 159 0.723
positive regulation of transcription elongation from rna polymerase ii promoter GO:0032968 2 0.723
retina morphogenesis in camera type eye GO:0060042 45 0.717
negative regulation of striated muscle cell differentiation GO:0051154 14 0.713
negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis GO:0072040 4 0.708
positive regulation of phospholipase c activity GO:0010863 2 0.698
positive regulation of neuron apoptotic process GO:0043525 25 0.698
regulation of myotube differentiation GO:0010830 62 0.694
bone development GO:0060348 120 0.692
enamel mineralization GO:0070166 7 0.685
heart field specification GO:0003128 6 0.680
specification of organ position GO:0010159 3 0.679
craniofacial suture morphogenesis GO:0097094 10 0.679
regulation of transcription from rna polymerase ii promoter involved in heart development GO:1901213 9 0.678
forebrain neuron differentiation GO:0021879 52 0.675
mesodermal to mesenchymal transition involved in gastrulation GO:0060809 1 0.673
regulation of cell projection organization GO:0031344 206 0.665
regulation of heart morphogenesis GO:2000826 22 0.656
endoderm formation GO:0001706 20 0.650
visual perception GO:0007601 52 0.646
regulation of cell migration GO:0030334 219 0.645
epithelial cell maturation involved in prostate gland development GO:0060743 4 0.640
cardiac neural crest cell migration involved in outflow tract morphogenesis GO:0003253 3 0.639
branching morphogenesis of an epithelial tube GO:0048754 159 0.638
t cell activation GO:0042110 289 0.634
formation of primary germ layer GO:0001704 77 0.629
cartilage morphogenesis GO:0060536 11 0.627
negative regulation of stem cell maintenance GO:1902455 4 0.619
positive regulation of cardioblast differentiation GO:0051891 3 0.618
pituitary gland development GO:0021983 38 0.617
positive regulation of transcription from rna polymerase ii promoter involved in heart development GO:1901228 4 0.613
tendon formation GO:0035992 4 0.612
cellular response to abiotic stimulus GO:0071214 56 0.604
striated muscle tissue development GO:0014706 293 0.604
negative regulation of cell proliferation GO:0008285 296 0.604
Mouse
ear development GO:0043583 200 0.603
regulation of glial cell differentiation GO:0045685 41 0.601
activation of meiosis GO:0090427 4 0.598
respiratory system development GO:0060541 190 0.597
embryonic forelimb morphogenesis GO:0035115 32 0.597
positive regulation of cell death GO:0010942 224 0.597
Mouse Fly
ear morphogenesis GO:0042471 118 0.597
locus ceruleus development GO:0021703 1 0.597
thyroid stimulating hormone secreting cell differentiation GO:0060129 4 0.596
regulation of cartilage development GO:0061035 44 0.591
negative regulation of cardiac chamber morphogenesis GO:1901220 2 0.591
metanephric nephron tubule formation GO:0072289 4 0.590
negative regulation of immature t cell proliferation GO:0033087 3 0.589
hemangioblast cell differentiation GO:0060217 1 0.589
atrial ventricular junction remodeling GO:0003294 2 0.586
regulation of planar cell polarity pathway involved in outflow tract morphogenesis GO:2000163 1 0.584
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.583
reactive oxygen species metabolic process GO:0072593 84 0.581
metanephric capsule specification GO:0072267 1 0.580
gastrulation GO:0007369 116 0.580
Fly
leukocyte proliferation GO:0070661 172 0.580
formation of radial glial scaffolds GO:0021943 4 0.577
telencephalon regionalization GO:0021978 14 0.576
regulation of cellular amine metabolic process GO:0033238 20 0.575
lung development GO:0030324 164 0.574
keratinocyte proliferation GO:0043616 21 0.573
neuroepithelial cell differentiation GO:0060563 37 0.573
axial mesodermal cell fate commitment GO:0048322 1 0.572
skeletal muscle fiber development GO:0048741 58 0.567
germ cell development GO:0007281 185 0.567
cytokine mediated signaling pathway GO:0019221 115 0.559
negative regulation of osteoblast differentiation GO:0045668 30 0.558
positive regulation of mesenchymal cell proliferation GO:0002053 33 0.556
inflammatory response GO:0006954 244 0.554
commitment of neuronal cell to specific neuron type in forebrain GO:0021902 7 0.553
cartilage condensation GO:0001502 18 0.550
noradrenergic neuron development GO:0003358 3 0.546
mammary gland morphogenesis GO:0060443 54 0.545
cellular protein catabolic process GO:0044257 155 0.543
regulation of reactive oxygen species metabolic process GO:2000377 40 0.540
glial cell differentiation GO:0010001 131 0.538
muscle fiber development GO:0048747 76 0.536
face morphogenesis GO:0060325 29 0.535
angiogenesis GO:0001525 201 0.534
Mouse
striated muscle cell development GO:0055002 125 0.532
regulation of feeding behavior GO:0060259 3 0.532
retina development in camera type eye GO:0060041 119 0.530
positive regulation of bmp signaling pathway GO:0030513 23 0.529
body morphogenesis GO:0010171 45 0.526
trophectodermal cellular morphogenesis GO:0001831 3 0.523
negative regulation of gastrulation GO:2000542 3 0.522
muscle cell proliferation GO:0033002 52 0.520
mitral valve morphogenesis GO:0003183 4 0.517
positive regulation of stem cell differentiation GO:2000738 23 0.513
ovulation cycle GO:0042698 59 0.512
regulation of skeletal muscle fiber differentiation GO:1902809 3 0.510
eye photoreceptor cell development GO:0042462 31 0.509
Fly
oculomotor nerve morphogenesis GO:0021622 2 0.508
positive regulation of fat cell differentiation GO:0045600 32 0.506
negative regulation of lymphocyte differentiation GO:0045620 32 0.505
negative regulation of apoptotic process involved in outflow tract morphogenesis GO:1902257 2 0.504
pattern specification involved in metanephros development GO:0072268 4 0.494
skin morphogenesis GO:0043589 38 0.493
Mouse
rhythmic process GO:0048511 174 0.491
oocyte differentiation GO:0009994 35 0.485
cell maturation GO:0048469 127 0.481
positive regulation of endothelial cell proliferation GO:0001938 17 0.480
stem cell proliferation GO:0072089 117 0.479
heart valve morphogenesis GO:0003179 21 0.478
negative regulation of cell fate specification GO:0009996 4 0.478
face development GO:0060324 38 0.478
amine metabolic process GO:0009308 45 0.477
carbon catabolite activation of transcription GO:0045991 4 0.476
response to organic cyclic compound GO:0014070 198 0.475
neural tube patterning GO:0021532 43 0.467
regulation of mapk cascade GO:0043408 248 0.467
sinoatrial node cell development GO:0060931 3 0.466
positive regulation of apoptotic signaling pathway GO:2001235 95 0.460
Mouse
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.460
covalent chromatin modification GO:0016569 163 0.459
negative regulation of canonical wnt signaling pathway involved in neural plate anterior posterior pattern formation GO:0060829 1 0.459
regulation of peptide secretion GO:0002791 77 0.458
trachea cartilage morphogenesis GO:0060535 4 0.457
cell division GO:0051301 120 0.456
regulation of muscle tissue development GO:1901861 97 0.455
pyramidal neuron migration GO:0021852 1 0.453
lymphocyte differentiation GO:0030098 242 0.449
lipid biosynthetic process GO:0008610 179 0.446
positive regulation of cartilage development GO:0061036 18 0.445
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 40 0.443
hair cycle GO:0042633 90 0.443
Mouse
metanephric mesenchyme morphogenesis GO:0072133 4 0.442
mesoderm formation GO:0001707 62 0.442
response to nutrient levels GO:0031667 109 0.439
cellular response to inorganic substance GO:0071241 37 0.435
positive regulation of programmed cell death GO:0043068 218 0.432
Mouse Fly
protein modification by small protein conjugation or removal GO:0070647 207 0.430
fat cell differentiation GO:0045444 160 0.430
pigment cell differentiation GO:0050931 27 0.429
chromatin modification GO:0016568 187 0.426
anterior commissure morphogenesis GO:0021960 6 0.426
negative regulation of molecular function GO:0044092 258 0.425
lung epithelium development GO:0060428 37 0.422
positive regulation of tongue muscle cell differentiation GO:2001037 2 0.422
cellular amine metabolic process GO:0044106 44 0.421
pancreatic pp cell fate commitment GO:0003329 2 0.420
positive regulation of odontogenesis GO:0042482 4 0.419
floor plate morphogenesis GO:0033505 3 0.419
sensory perception GO:0007600 245 0.418
negative regulation of apoptotic process involved in morphogenesis GO:1902338 6 0.417
regulation of erk1 and erk2 cascade GO:0070372 71 0.412
cellular amino acid metabolic process GO:0006520 103 0.408
negative regulation of chondrocyte differentiation GO:0032331 13 0.407
osteoclast differentiation GO:0030316 62 0.406
positive regulation of cell cycle GO:0045787 92 0.406
positive regulation of glial cell differentiation GO:0045687 21 0.403
regulation of lipase activity GO:0060191 15 0.398
ameboidal type cell migration GO:0001667 128 0.398
positive regulation of vascular wound healing GO:0035470 1 0.395
positive regulation of hh target transcription factor activity GO:0007228 3 0.392
semicircular canal morphogenesis GO:0048752 7 0.391
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.390
Mouse
cerebral cortex development GO:0021987 86 0.387
cell differentiation involved in kidney development GO:0061005 33 0.387
cardiac right ventricle formation GO:0003219 3 0.386
neural nucleus development GO:0048857 22 0.386
cardiac muscle cell development GO:0055013 39 0.384
cranial suture morphogenesis GO:0060363 8 0.384
cellular response to cytokine stimulus GO:0071345 189 0.380
negative regulation of planar cell polarity pathway involved in heart morphogenesis GO:2000160 1 0.379
endocardial cushion formation GO:0003272 13 0.379
endocardial cushion to mesenchymal transition involved in heart valve formation GO:0003199 4 0.378
regulation of mesenchymal cell proliferation GO:0010464 37 0.378
corticotropin hormone secreting cell differentiation GO:0060128 3 0.376
positive regulation of cell migration GO:0030335 109 0.376
positive regulation of wnt signaling pathway GO:0030177 45 0.372
regulation of lymphocyte activation GO:0051249 240 0.368
oocyte axis specification GO:0007309 2 0.368
cytokine production GO:0001816 319 0.367
Mouse
cellular ketone metabolic process GO:0042180 84 0.367
cerebral cortex tangential migration GO:0021800 7 0.364
regulation of transcription involved in primary germ layer cell fate commitment GO:0060796 2 0.360
prostate epithelial cord elongation GO:0060523 3 0.359
erk1 and erk2 cascade GO:0070371 77 0.359
cell proliferation in external granule layer GO:0021924 10 0.359
appendage development GO:0048736 166 0.359
epithelial cell proliferation involved in prostate gland development GO:0060767 11 0.358
calcium ion transport GO:0006816 159 0.356
regulation of cell proliferation involved in heart morphogenesis GO:2000136 15 0.355
atrioventricular bundle cell differentiation GO:0003167 1 0.353
eye photoreceptor cell differentiation GO:0001754 41 0.353
Fly
myotube differentiation GO:0014902 105 0.353
positive regulation of bone mineralization GO:0030501 12 0.352
jak stat cascade GO:0007259 42 0.350
camera type eye photoreceptor cell differentiation GO:0060219 15 0.349
oogenesis GO:0048477 56 0.343
tube formation GO:0035148 140 0.343
morphogenesis of embryonic epithelium GO:0016331 159 0.341
regulation of lymphocyte differentiation GO:0045619 107 0.340
negative regulation of protein metabolic process GO:0051248 282 0.337
trophectodermal cell differentiation GO:0001829 21 0.334
regulation of apoptotic process involved in morphogenesis GO:1902337 10 0.333
circulatory system process GO:0003013 197 0.331
cerebral cortex cell migration GO:0021795 44 0.331
wnt signaling pathway involved in forebrain neuroblast division GO:0021874 2 0.330
germ line stem cell division GO:0042078 2 0.327
medulla oblongata development GO:0021550 3 0.324
cell fate specification GO:0001708 72 0.324
organic hydroxy compound metabolic process GO:1901615 203 0.324
mammary gland bud formation GO:0060615 2 0.323
cellular macromolecule catabolic process GO:0044265 206 0.322
noradrenergic neuron differentiation GO:0003357 6 0.322
multicellular organismal homeostasis GO:0048871 164 0.321
c21 steroid hormone biosynthetic process GO:0006700 3 0.321
negative regulation of t cell proliferation GO:0042130 38 0.321
oocyte construction GO:0007308 2 0.320
negative regulation of transcription from rna polymerase ii promoter by glucose GO:0000433 1 0.317
regulation of cardiac chamber formation GO:1901210 1 0.317
response to amino acid GO:0043200 37 0.317
regulation of stem cell proliferation GO:0072091 78 0.316
wound healing spreading of cells GO:0044319 8 0.315
negative regulation of endodermal cell differentiation GO:1903225 1 0.314
tissue homeostasis GO:0001894 115 0.312
muscle tissue development GO:0060537 308 0.309
regulation of canonical wnt signaling pathway GO:0060828 82 0.309
forebrain radial glial cell differentiation GO:0021861 4 0.308
kidney vasculature morphogenesis GO:0061439 7 0.308
oocyte development GO:0048599 33 0.307
ectodermal placode morphogenesis GO:0071697 16 0.305
spermatid differentiation GO:0048515 115 0.301
alpha beta t cell activation GO:0046631 91 0.300
positive regulation of gliogenesis GO:0014015 27 0.299
mammary gland epithelium development GO:0061180 65 0.298
positive regulation of mesenchymal cell apoptotic process GO:2001055 3 0.297
gliogenesis GO:0042063 141 0.297
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.297
left lung morphogenesis GO:0060460 3 0.296
negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis GO:2000149 1 0.295
regulation of bmp signaling pathway GO:0030510 60 0.295
neuron migration GO:0001764 122 0.295
regulation of stem cell maintenance GO:2000036 17 0.294
negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis GO:2000162 1 0.293
generation of precursor metabolites and energy GO:0006091 103 0.292
epidermal growth factor receptor signaling pathway GO:0007173 28 0.292
prostate gland morphogenesis GO:0060512 32 0.292
cellular response to external stimulus GO:0071496 88 0.292
regulation of planar cell polarity pathway involved in neural tube closure GO:2000167 1 0.291
neural tube formation GO:0001841 108 0.286
maternal placenta development GO:0001893 20 0.286
positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0072108 3 0.286
proteoglycan metabolic process GO:0006029 38 0.285
regulation of cell division GO:0051302 76 0.285
regulation of chromatin modification GO:1903308 57 0.284
embryonic epithelial tube formation GO:0001838 130 0.283
lung epithelial cell differentiation GO:0060487 29 0.282
carbon catabolite repression of transcription GO:0045013 1 0.282
negative regulation of kinase activity GO:0033673 81 0.281
neural tube development GO:0021915 160 0.281
cardiac muscle tissue development GO:0048738 130 0.280
organ growth GO:0035265 117 0.279
cell differentiation involved in embryonic placenta development GO:0060706 26 0.279
regulation of neuron projection development GO:0010975 169 0.277
regulation of myeloid leukocyte differentiation GO:0002761 58 0.277
middle ear morphogenesis GO:0042474 23 0.276
cellular response to amino acid stimulus GO:0071230 29 0.274
spinal cord oligodendrocyte cell fate specification GO:0021530 3 0.273
cerebellar granule cell precursor proliferation GO:0021930 10 0.272
olfactory lobe development GO:0021988 32 0.271
cellular response to mechanical stimulus GO:0071260 7 0.271
metanephric glomerulus vasculature morphogenesis GO:0072276 3 0.270
positive regulation of transcription by glucose GO:0046016 3 0.270
positive regulation of neuron projection regeneration GO:0070572 2 0.268
cell proliferation in forebrain GO:0021846 30 0.268
regulation of tongue muscle cell differentiation GO:2001035 2 0.267
ribose phosphate metabolic process GO:0019693 291 0.267
smooth muscle tissue development GO:0048745 22 0.266
epidermis development GO:0008544 187 0.264
Mouse
axonogenesis GO:0007409 274 0.264
Mouse Fly
cerebral cortex gabaergic interneuron fate commitment GO:0021893 2 0.264
smad protein signal transduction GO:0060395 21 0.263
regulation of cellular amino acid metabolic process GO:0006521 5 0.263
carbohydrate catabolic process GO:0016052 32 0.262
granulosa cell differentiation GO:0060014 1 0.262
inner ear morphogenesis GO:0042472 101 0.261
mitochondrion distribution GO:0048311 4 0.261
forebrain regionalization GO:0021871 25 0.261
smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation GO:0021938 4 0.261
roof plate formation GO:0021509 1 0.259
glomerulus vasculature morphogenesis GO:0072103 6 0.259
negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis GO:2000164 1 0.256
negative regulation of transcription by glucose GO:0045014 1 0.255
skeletal muscle cell differentiation GO:0035914 66 0.255
growth plate cartilage development GO:0003417 14 0.250
carbon catabolite regulation of transcription GO:0045990 4 0.249
neural crest cell development GO:0014032 48 0.248
vagus nerve morphogenesis GO:0021644 2 0.247
regulation of mesenchymal cell apoptotic process GO:2001053 14 0.246
regulation of neuron differentiation GO:0045664 281 0.246
positive regulation of chondrocyte differentiation GO:0032332 13 0.246
vascular wound healing GO:0061042 3 0.245
negative regulation of keratinocyte differentiation GO:0045617 4 0.245
canonical wnt signaling pathway involved in cardiac neural crest cell differentiation involved in heart development GO:0061310 1 0.243
positive regulation of alpha beta t cell differentiation GO:0046638 28 0.243
mammary gland duct morphogenesis GO:0060603 38 0.243
negative regulation of cholesterol transport GO:0032375 4 0.243
mesenchymal cell differentiation involved in lung development GO:0060915 2 0.243
regulation of planar cell polarity pathway involved in heart morphogenesis GO:2000159 1 0.242
regulation of skeletal muscle cell differentiation GO:2001014 11 0.240
axis elongation GO:0003401 30 0.238
cardiac left ventricle formation GO:0003218 1 0.238
regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis GO:2000161 1 0.238
regulation of endocardial cushion to mesenchymal transition involved in heart valve formation GO:2000800 1 0.236
regulation of b cell activation GO:0050864 81 0.235
smooth muscle cell migration GO:0014909 10 0.234
transmembrane transport GO:0055085 412 0.231
positive regulation of canonical wnt signaling pathway GO:0090263 29 0.230
regulation of cytokine production GO:0001817 266 0.229
cardiocyte differentiation GO:0035051 87 0.229
epithelial cell differentiation involved in kidney development GO:0035850 23 0.228
tube closure GO:0060606 91 0.227
positive regulation of dna templated transcription elongation GO:0032786 2 0.226
mesangial cell differentiation GO:0072007 4 0.226
hair follicle morphogenesis GO:0031069 29 0.225
Mouse
synaptic transmission GO:0007268 329 0.225
pronephric field specification GO:0039003 2 0.224
regulation of phospholipase c activity GO:1900274 3 0.224
positive regulation of cardiac muscle cell proliferation GO:0060045 15 0.223
second messenger mediated signaling GO:0019932 73 0.222
olfactory bulb development GO:0021772 30 0.221
positive regulation of branching involved in lung morphogenesis GO:0061047 4 0.221
intestinal epithelial structure maintenance GO:0060729 4 0.221
lateral line system development GO:0048925 1 0.220
positive regulation of skeletal muscle fiber differentiation GO:1902811 2 0.220
negative regulation of cell cycle GO:0045786 123 0.220
Mouse
molting cycle GO:0042303 90 0.220
Mouse
cerebral cortex gabaergic interneuron development GO:0021894 6 0.220
lung cell differentiation GO:0060479 30 0.219
cardiac chamber development GO:0003205 108 0.219
cellular response to fluid shear stress GO:0071498 4 0.218
negative regulation of wnt signaling pathway involved in heart development GO:0003308 4 0.218
chromatin organization GO:0006325 206 0.217
embryonic placenta development GO:0001892 98 0.217
mesodermal cell fate commitment GO:0001710 17 0.216
thalamus development GO:0021794 11 0.215
defense response to other organism GO:0098542 197 0.213
blood circulation GO:0008015 195 0.212
astrocyte fate commitment GO:0060018 4 0.211
regulation of smooth muscle cell differentiation GO:0051150 9 0.211
histone modification GO:0016570 159 0.211
mesoderm development GO:0007498 100 0.211

Runx2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.998
Human
musculoskeletal system disease DOID:17 0 0.998
Human
connective tissue disease DOID:65 0 0.998
Human
bone disease DOID:0080001 0 0.978
Human
bone remodeling disease DOID:0080005 0 0.767
bone development disease DOID:0080006 0 0.469
Human
dysostosis DOID:1934 0 0.469
osteosclerosis DOID:4254 0 0.277