Mus musculus

21 known processes

Sesn1

sestrin 1

(Aliases: 1110002G11Rik,Pa26,Sest1,MGC118148,AU044290)

Sesn1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
positive regulation of apoptotic process GO:0043065 217 0.184
synaptic transmission GO:0007268 329 0.149
cellular response to dna damage stimulus GO:0006974 207 0.144
positive regulation of programmed cell death GO:0043068 218 0.135
apoptotic signaling pathway GO:0097190 306 0.133
positive regulation of cell death GO:0010942 224 0.107
muscle tissue development GO:0060537 308 0.090
cellular ketone metabolic process GO:0042180 84 0.080
macromolecule methylation GO:0043414 120 0.079
methylation GO:0032259 134 0.073
peptidyl amino acid modification GO:0018193 336 0.070
response to oxidative stress GO:0006979 123 0.069
cell cycle checkpoint GO:0000075 47 0.069
intrinsic apoptotic signaling pathway GO:0097193 132 0.067
protein alkylation GO:0008213 81 0.064
regulation of reactive oxygen species metabolic process GO:2000377 40 0.062
regulation of cellular ketone metabolic process GO:0010565 66 0.061
negative regulation of cell cycle GO:0045786 123 0.058
regulation of apoptotic signaling pathway GO:2001233 197 0.056
positive regulation of transcription elongation from rna polymerase ii promoter GO:0032968 2 0.048
negative regulation of cell proliferation GO:0008285 296 0.048
adaptive immune response GO:0002250 155 0.048
organophosphate biosynthetic process GO:0090407 122 0.045
carbohydrate metabolic process GO:0005975 230 0.044
cellular response to hormone stimulus GO:0032870 150 0.043
cell type specific apoptotic process GO:0097285 268 0.043
cellular amino acid metabolic process GO:0006520 103 0.043
negative regulation of protein metabolic process GO:0051248 282 0.042
g protein coupled receptor signaling pathway GO:0007186 243 0.041
striated muscle tissue development GO:0014706 293 0.041
glucose homeostasis GO:0042593 128 0.040
Mouse
negative regulation of mitotic cell cycle GO:0045930 58 0.040
regulation of zinc ion transport GO:0071579 2 0.040
protein methylation GO:0006479 81 0.039
fat cell differentiation GO:0045444 160 0.039
gene silencing GO:0016458 38 0.039
regulation of cellular amino acid metabolic process GO:0006521 5 0.038
mitotic cell cycle process GO:1903047 159 0.038
chromatin modification GO:0016568 187 0.037
multicellular organism growth GO:0035264 161 0.036
nucleotide metabolic process GO:0009117 332 0.035
cellular response to organonitrogen compound GO:0071417 145 0.034
stem cell development GO:0048864 219 0.033
positive regulation of protein modification process GO:0031401 299 0.033
regulation of cellular response to stress GO:0080135 159 0.033
nucleoside triphosphate metabolic process GO:0009141 230 0.032
neurotransmitter secretion GO:0007269 62 0.032
stem cell maintenance GO:0019827 130 0.031
regulation of cell cycle process GO:0010564 160 0.031
regulation of synaptic plasticity GO:0048167 87 0.031
positive regulation of dna templated transcription elongation GO:0032786 2 0.031
carbohydrate derivative biosynthetic process GO:1901137 183 0.031
regulation of glucose metabolic process GO:0010906 60 0.030
response to inorganic substance GO:0010035 96 0.030
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.029
regulation of cell cycle GO:0051726 281 0.029
heterocycle catabolic process GO:0046700 280 0.029
dna metabolic process GO:0006259 303 0.029
generation of precursor metabolites and energy GO:0006091 103 0.028
glycogen metabolic process GO:0005977 32 0.028
response to organonitrogen compound GO:0010243 246 0.027
Mouse
mitotic cell cycle GO:0000278 195 0.027
stem cell differentiation GO:0048863 268 0.027
lipid phosphorylation GO:0046834 25 0.027
oxidation reduction process GO:0055114 342 0.026
neuron death GO:0070997 154 0.026
skeletal muscle organ development GO:0060538 163 0.026
positive regulation of apoptotic signaling pathway GO:2001235 95 0.026
carbohydrate biosynthetic process GO:0016051 74 0.026
muscle cell development GO:0055001 133 0.026
leukocyte differentiation GO:0002521 342 0.025
neuron apoptotic process GO:0051402 142 0.025
positive regulation of cellular amine metabolic process GO:0033240 5 0.025
muscle cell differentiation GO:0042692 261 0.025
extrinsic apoptotic signaling pathway GO:0097191 126 0.025
regulation of carbohydrate biosynthetic process GO:0043255 40 0.025
long term synaptic potentiation GO:0060291 25 0.024
cellular carbohydrate metabolic process GO:0044262 119 0.024
rhythmic process GO:0048511 174 0.024
negative regulation of mitotic cell cycle phase transition GO:1901991 45 0.024
negative regulation of cellular component organization GO:0051129 194 0.024
organic cyclic compound catabolic process GO:1901361 295 0.024
protein modification by small protein conjugation or removal GO:0070647 207 0.023
negative regulation of phosphorylation GO:0042326 166 0.023
negative regulation of phosphorus metabolic process GO:0010563 184 0.023
negative regulation of phosphate metabolic process GO:0045936 184 0.023
signal transduction by p53 class mediator GO:0072331 51 0.023
nucleoside phosphate metabolic process GO:0006753 338 0.023
cell cycle g1 s phase transition GO:0044843 57 0.023
regulation of histone modification GO:0031056 56 0.023
ribonucleoside metabolic process GO:0009119 245 0.022
protein modification by small protein conjugation GO:0032446 187 0.022
cellular lipid metabolic process GO:0044255 323 0.022
regulation of secretion GO:0051046 274 0.022
negative regulation of protein maturation GO:1903318 79 0.022
cation transport GO:0006812 399 0.022
histone modification GO:0016570 159 0.022
regulation of organelle organization GO:0033043 289 0.021
phosphatidylinositol phosphorylation GO:0046854 23 0.021
mitochondrion organization GO:0007005 134 0.021
regulation of myeloid cell differentiation GO:0045637 96 0.021
digestive tract development GO:0048565 190 0.021
amine metabolic process GO:0009308 45 0.021
response to peptide hormone GO:0043434 127 0.021
Mouse
lipid biosynthetic process GO:0008610 179 0.021
vesicle localization GO:0051648 86 0.020
myeloid leukocyte differentiation GO:0002573 119 0.020
response to radiation GO:0009314 165 0.020
embryonic organ morphogenesis GO:0048562 276 0.020
blastocyst development GO:0001824 80 0.020
nucleobase containing small molecule metabolic process GO:0055086 352 0.020
pyruvate metabolic process GO:0006090 28 0.020
carbohydrate catabolic process GO:0016052 32 0.020
protein processing GO:0016485 163 0.019
ossification GO:0001503 216 0.019
regulation of cellular amine metabolic process GO:0033238 20 0.019
regulation of lipid metabolic process GO:0019216 118 0.019
glucan metabolic process GO:0044042 32 0.019
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 57 0.019
protein localization to chromatin GO:0071168 3 0.019
regulation of intrinsic apoptotic signaling pathway GO:2001242 61 0.019
regulation of myeloid leukocyte differentiation GO:0002761 58 0.019
regulation of cell migration GO:0030334 219 0.019
polysaccharide metabolic process GO:0005976 39 0.019
regulation of cytokine production GO:0001817 266 0.019
cytokine production GO:0001816 319 0.019
regulation of g protein coupled receptor protein signaling pathway GO:0008277 37 0.019
skeletal muscle cell differentiation GO:0035914 66 0.019
negative regulation of cellular protein metabolic process GO:0032269 247 0.018
purine nucleotide metabolic process GO:0006163 302 0.018
cellular protein complex assembly GO:0043623 116 0.018
response to light stimulus GO:0009416 135 0.018
myeloid cell differentiation GO:0030099 233 0.018
nuclear transcribed mrna catabolic process nonsense mediated decay GO:0000184 1 0.018
regulation of transmembrane transport GO:0034762 128 0.018
smoothened signaling pathway GO:0007224 105 0.018
male gamete generation GO:0048232 285 0.017
regulation of lymphocyte activation GO:0051249 240 0.017
dna recombination GO:0006310 92 0.017
signal transduction in absence of ligand GO:0038034 55 0.017
chromatin silencing GO:0006342 15 0.017
cellular macromolecule catabolic process GO:0044265 206 0.017
regulation of hydrolase activity GO:0051336 246 0.017
ribose phosphate metabolic process GO:0019693 291 0.016
response to insulin GO:0032868 100 0.016
Mouse
regulation of feeding behavior GO:0060259 3 0.016
glucose metabolic process GO:0006006 92 0.016
circadian rhythm GO:0007623 114 0.016
regulation of leukocyte differentiation GO:1902105 159 0.016
regulation of establishment of protein localization GO:0070201 181 0.016
ribonucleotide metabolic process GO:0009259 291 0.016
mitochondrial genome maintenance GO:0000002 15 0.016
positive regulation of growth GO:0045927 104 0.016
negative regulation of cell cycle process GO:0010948 69 0.016
t cell activation GO:0042110 289 0.016
cellular response to peptide hormone stimulus GO:0071375 92 0.016
regulation of ion transmembrane transport GO:0034765 119 0.016
digestive tract morphogenesis GO:0048546 147 0.016
regulation of chromatin silencing GO:0031935 2 0.016
purine nucleoside metabolic process GO:0042278 241 0.016
transmembrane transport GO:0055085 412 0.016
nuclear division GO:0000280 158 0.016
cellular amine metabolic process GO:0044106 44 0.016
nucleotide biosynthetic process GO:0009165 78 0.016
histone lysine demethylation GO:0070076 13 0.015
mitotic cell cycle checkpoint GO:0007093 31 0.015
peptidyl serine modification GO:0018209 83 0.015
divalent inorganic cation transport GO:0072511 178 0.015
microtubule based process GO:0007017 236 0.015
aromatic compound catabolic process GO:0019439 286 0.015
membrane organization GO:0061024 245 0.015
regulation of mitotic cell cycle phase transition GO:1901990 73 0.015
regulation of binding GO:0051098 111 0.015
regulation of postsynaptic membrane potential GO:0060078 48 0.015
maintenance of location GO:0051235 89 0.015
digestive system development GO:0055123 200 0.015
establishment of protein localization to membrane GO:0090150 54 0.015
hexose metabolic process GO:0019318 98 0.015
response to extracellular stimulus GO:0009991 127 0.015
dna endoreduplication GO:0042023 4 0.015
cell division GO:0051301 120 0.015
purine ribonucleotide metabolic process GO:0009150 290 0.015
g1 s transition of mitotic cell cycle GO:0000082 57 0.014
glycerophospholipid biosynthetic process GO:0046474 32 0.014
regulation of cell activation GO:0050865 289 0.014
defense response to bacterium GO:0042742 119 0.014
negative regulation of organelle organization GO:0010639 90 0.014
dna repair GO:0006281 107 0.014
chromatin organization GO:0006325 206 0.014
response to nutrient levels GO:0031667 109 0.014
organelle localization GO:0051640 179 0.014
guanosine containing compound catabolic process GO:1901069 144 0.014
purine containing compound metabolic process GO:0072521 311 0.014
macromolecule catabolic process GO:0009057 281 0.014
sensory perception of sound GO:0007605 97 0.014
purine ribonucleotide catabolic process GO:0009154 208 0.014
positive regulation of defense response GO:0031349 124 0.014
phospholipid metabolic process GO:0006644 87 0.014
glucocorticoid mediated signaling pathway GO:0043402 3 0.014
negative regulation of cell cycle phase transition GO:1901988 48 0.013
regulation of neuron apoptotic process GO:0043523 122 0.013
cell adhesion GO:0007155 329 0.013
establishment of vesicle localization GO:0051650 81 0.013
regulation of membrane potential GO:0042391 192 0.013
developmental maturation GO:0021700 193 0.013
multi multicellular organism process GO:0044706 109 0.013
cytokine mediated signaling pathway GO:0019221 115 0.013
regulation of protein processing GO:0070613 96 0.013
neurotransmitter transport GO:0006836 76 0.013
purine nucleoside triphosphate metabolic process GO:0009144 226 0.013
multicellular organismal signaling GO:0035637 91 0.013
nucleoside phosphate catabolic process GO:1901292 222 0.013
mitotic sister chromatid cohesion GO:0007064 1 0.013
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 87 0.013
regulation of cellular carbohydrate metabolic process GO:0010675 75 0.013
dna damage checkpoint GO:0000077 26 0.013
histone lysine methylation GO:0034968 50 0.013
nucleoside catabolic process GO:0009164 206 0.013
response to molecule of bacterial origin GO:0002237 143 0.013
spermatid differentiation GO:0048515 115 0.013
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.012
cellular response to abiotic stimulus GO:0071214 56 0.012
carbohydrate homeostasis GO:0033500 128 0.012
Mouse
mapk cascade GO:0000165 281 0.012
monosaccharide biosynthetic process GO:0046364 44 0.012
phospholipid biosynthetic process GO:0008654 36 0.012
b cell activation GO:0042113 161 0.012
cellular response to lipid GO:0071396 145 0.012
canonical wnt signaling pathway GO:0060070 130 0.012
spermatogenesis GO:0007283 284 0.012
positive regulation of protein phosphorylation GO:0001934 242 0.012
regulation of protein maturation GO:1903317 96 0.012
leukocyte proliferation GO:0070661 172 0.012
response to peptide GO:1901652 136 0.012
Mouse
regulation of fat cell differentiation GO:0045598 81 0.012
myosin filament assembly GO:0031034 2 0.012
cardiac muscle contraction GO:0060048 32 0.012
energy derivation by oxidation of organic compounds GO:0015980 77 0.012
cellular chemical homeostasis GO:0055082 215 0.012
histone h4 k16 acetylation GO:0043984 3 0.012
hexose biosynthetic process GO:0019319 39 0.012
regulation of protein binding GO:0043393 60 0.012
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.012
mrna catabolic process GO:0006402 22 0.012
protein ubiquitination GO:0016567 171 0.012
covalent chromatin modification GO:0016569 163 0.012
small molecule catabolic process GO:0044282 71 0.012
nucleoside phosphate biosynthetic process GO:1901293 79 0.012
protein maturation GO:0051604 176 0.012
glycerophospholipid metabolic process GO:0006650 71 0.012
positive regulation of myeloid cell apoptotic process GO:0033034 4 0.011
dendrite development GO:0016358 115 0.011
dna integrity checkpoint GO:0031570 28 0.011
rna catabolic process GO:0006401 29 0.011
retrograde transport endosome to golgi GO:0042147 2 0.011
protein autophosphorylation GO:0046777 61 0.011
cellular nitrogen compound catabolic process GO:0044270 280 0.011
monocarboxylic acid metabolic process GO:0032787 191 0.011
wnt signaling pathway GO:0016055 188 0.011
inorganic cation transmembrane transport GO:0098662 207 0.011
response to lipopolysaccharide GO:0032496 128 0.011
establishment of organelle localization GO:0051656 122 0.011
regulation of peptidase activity GO:0052547 96 0.011
myosin filament organization GO:0031033 3 0.011
positive regulation of fibroblast growth factor receptor signaling pathway GO:0045743 3 0.011
hematopoietic progenitor cell differentiation GO:0002244 143 0.011
peptidyl tyrosine modification GO:0018212 145 0.011
negative regulation of glycoprotein metabolic process GO:1903019 3 0.011
glycolytic process GO:0006096 20 0.011
organonitrogen compound biosynthetic process GO:1901566 192 0.011
compound eye development GO:0048749 1 0.011
cation transmembrane transport GO:0098655 266 0.011
negative regulation of molecular function GO:0044092 258 0.011
organelle fission GO:0048285 170 0.011
phosphatidylinositol biosynthetic process GO:0006661 15 0.011
cardiac muscle cell differentiation GO:0055007 69 0.011
substantia nigra development GO:0021762 2 0.011
regulation of cell cycle phase transition GO:1901987 77 0.011
sensory perception GO:0007600 245 0.011
purine nucleotide biosynthetic process GO:0006164 65 0.011
regulation of protein transport GO:0051223 163 0.011
intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 35 0.011
circulatory system process GO:0003013 197 0.011
carbohydrate derivative catabolic process GO:1901136 231 0.011
divalent inorganic cation homeostasis GO:0072507 138 0.010
response to acid chemical GO:0001101 111 0.010
regulation of secretion by cell GO:1903530 249 0.010
protein localization to nucleus GO:0034504 121 0.010
cellular response to lipopolysaccharide GO:0071222 77 0.010
purine ribonucleoside metabolic process GO:0046128 241 0.010
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.010
regionalization GO:0003002 337 0.010
cohesin localization to chromatin GO:0071921 1 0.010
protein acylation GO:0043543 64 0.010
response to reactive oxygen species GO:0000302 56 0.010
germ cell development GO:0007281 185 0.010
cellular response to external stimulus GO:0071496 88 0.010

Sesn1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
sensory system disease DOID:0050155 0 0.013
disease of anatomical entity DOID:7 0 0.013
eye and adnexa disease DOID:1492 0 0.013
nervous system disease DOID:863 0 0.013
eye disease DOID:5614 0 0.013