Mus musculus

35 known processes

Setx

senataxin

(Aliases: mKIAA0625,SCAR1,Als4,AW060766,A930037J23Rik,A130090N03,AOA2,Sen1)

Setx biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
histone h3 k9 methylation GO:0051567 17 0.666
negative regulation of histone methylation GO:0031061 10 0.599
histone methylation GO:0016571 71 0.587
histone lysine methylation GO:0034968 50 0.544
positive regulation of histone h3 k27 methylation GO:0061087 4 0.459
protein methylation GO:0006479 81 0.373
positive regulation of histone h3 k9 methylation GO:0051574 4 0.371
regulation of chromosome organization GO:0033044 83 0.288
protein alkylation GO:0008213 81 0.273
positive regulation of chromatin modification GO:1903310 28 0.268
regulation of histone h3 k9 methylation GO:0051570 8 0.238
regulation of histone methylation GO:0031060 30 0.207
dna modification GO:0006304 50 0.197
positive regulation of histone methylation GO:0031062 16 0.172
macromolecule methylation GO:0043414 120 0.161
protein localization to organelle GO:0033365 185 0.153
peptidyl amino acid modification GO:0018193 336 0.138
purine containing compound metabolic process GO:0072521 311 0.137
regulation of chromatin modification GO:1903308 57 0.133
stem cell differentiation GO:0048863 268 0.129
ribose phosphate metabolic process GO:0019693 291 0.126
ribonucleoside triphosphate metabolic process GO:0009199 220 0.122
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.115
dna metabolic process GO:0006259 303 0.113
negative regulation of cellular component organization GO:0051129 194 0.113
covalent chromatin modification GO:0016569 163 0.109
ras protein signal transduction GO:0007265 77 0.106
nucleoside triphosphate catabolic process GO:0009143 205 0.100
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.097
glycosyl compound catabolic process GO:1901658 206 0.096
ribonucleoside metabolic process GO:0009119 245 0.095
nucleosome positioning GO:0016584 4 0.093
stem cell development GO:0048864 219 0.091
methylation GO:0032259 134 0.090
histone h3 k27 methylation GO:0070734 11 0.089
regulation of histone h3 k27 methylation GO:0061085 6 0.088
purine containing compound catabolic process GO:0072523 213 0.087
protein localization to chromatin GO:0071168 3 0.087
ribonucleoside triphosphate catabolic process GO:0009203 199 0.085
nucleoside metabolic process GO:0009116 246 0.084
purine nucleoside metabolic process GO:0042278 241 0.083
purine nucleoside triphosphate catabolic process GO:0009146 203 0.082
small gtpase mediated signal transduction GO:0007264 97 0.082
histone modification GO:0016570 159 0.080
purine ribonucleoside catabolic process GO:0046130 205 0.080
purine nucleoside catabolic process GO:0006152 205 0.079
maintenance of cell number GO:0098727 3 0.078
ribonucleotide metabolic process GO:0009259 291 0.078
nucleoside triphosphate metabolic process GO:0009141 230 0.076
stem cell maintenance GO:0019827 130 0.075
ribonucleoside catabolic process GO:0042454 206 0.075
purine ribonucleotide metabolic process GO:0009150 290 0.073
purine nucleotide catabolic process GO:0006195 211 0.072
negative regulation of cell proliferation GO:0008285 296 0.072
negative regulation of transcription elongation from rna polymerase ii promoter GO:0034244 6 0.071
positive regulation of organelle organization GO:0010638 128 0.071
purine ribonucleotide catabolic process GO:0009154 208 0.068
nucleoside phosphate catabolic process GO:1901292 222 0.066
regulation of organelle organization GO:0033043 289 0.065
negative regulation of chromosome organization GO:2001251 30 0.065
digestive tract morphogenesis GO:0048546 147 0.064
ribonucleotide catabolic process GO:0009261 208 0.064
regulation of apoptotic signaling pathway GO:2001233 197 0.064
mitotic cell cycle process GO:1903047 159 0.064
male gamete generation GO:0048232 285 0.062
nucleotide catabolic process GO:0009166 217 0.062
purine nucleoside triphosphate metabolic process GO:0009144 226 0.061
nucleoside catabolic process GO:0009164 206 0.061
organic cyclic compound catabolic process GO:1901361 295 0.058
regulation of cellular ketone metabolic process GO:0010565 66 0.057
positive regulation of chromosome organization GO:2001252 33 0.056
nucleotide metabolic process GO:0009117 332 0.055
purine nucleotide metabolic process GO:0006163 302 0.053
intracellular protein transport GO:0006886 204 0.051
nucleoside phosphate metabolic process GO:0006753 338 0.051
chromatin organization GO:0006325 206 0.050
mapk cascade GO:0000165 281 0.050
purine ribonucleoside metabolic process GO:0046128 241 0.049
genetic imprinting GO:0071514 27 0.049
spermatogenesis GO:0007283 284 0.049
nucleobase containing small molecule metabolic process GO:0055086 352 0.048
protein modification by small protein conjugation or removal GO:0070647 207 0.047
skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration GO:0014834 3 0.047
guanosine containing compound metabolic process GO:1901068 144 0.046
regulation of transferase activity GO:0051338 263 0.046
nuclear transport GO:0051169 139 0.046
organophosphate catabolic process GO:0046434 232 0.045
heterocycle catabolic process GO:0046700 280 0.045
organonitrogen compound catabolic process GO:1901565 264 0.045
positive regulation of protein modification process GO:0031401 299 0.044
positive regulation of histone modification GO:0031058 28 0.043
glycosyl compound metabolic process GO:1901657 246 0.043
cellular amino acid metabolic process GO:0006520 103 0.043
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 52 0.042
aromatic compound catabolic process GO:0019439 286 0.042
maintenance of protein location in nucleus GO:0051457 2 0.042
regulation of protein serine threonine kinase activity GO:0071900 157 0.041
cellular response to dna damage stimulus GO:0006974 207 0.041
positive regulation of transferase activity GO:0051347 167 0.039
nucleocytoplasmic transport GO:0006913 139 0.038
positive regulation of gtpase activity GO:0043547 85 0.038
regulation of chromatin organization GO:1902275 57 0.038
cellular amine metabolic process GO:0044106 44 0.037
cellular nitrogen compound catabolic process GO:0044270 280 0.036
membrane organization GO:0061024 245 0.035
cytoplasmic transport GO:0016482 234 0.035
carbohydrate derivative catabolic process GO:1901136 231 0.035
dendrite development GO:0016358 115 0.034
apoptotic signaling pathway GO:0097190 306 0.034
gtp metabolic process GO:0046039 144 0.033
chromatin modification GO:0016568 187 0.033
negative regulation of protein metabolic process GO:0051248 282 0.032
regulation of neuron differentiation GO:0045664 281 0.032
regulation of nucleoside metabolic process GO:0009118 130 0.032
cellular response to organonitrogen compound GO:0071417 145 0.031
regulation of cellular component biogenesis GO:0044087 181 0.031
regulation of cellular amino acid metabolic process GO:0006521 5 0.031
positive regulation of purine nucleotide catabolic process GO:0033123 88 0.031
regulation of mapk cascade GO:0043408 248 0.031
response to ionizing radiation GO:0010212 42 0.031
dna methylation GO:0006306 43 0.031
microtubule based process GO:0007017 236 0.030
posttranscriptional regulation of gene expression GO:0010608 155 0.030
positive regulation of cellular amine metabolic process GO:0033240 5 0.030
gland development GO:0048732 330 0.029
peptidyl serine modification GO:0018209 83 0.029
cellular lipid metabolic process GO:0044255 323 0.029
cytokinetic process GO:0032506 2 0.029
protein localization to nucleus GO:0034504 121 0.028
peptidyl serine phosphorylation GO:0018105 74 0.028
maturation of 5 8s rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna GO:0000466 1 0.028
regulation of protein kinase activity GO:0045859 232 0.028
cilium morphogenesis GO:0060271 102 0.027
organelle assembly GO:0070925 177 0.027
positive regulation of programmed cell death GO:0043068 218 0.027
protein ubiquitination GO:0016567 171 0.027
germ line stem cell division GO:0042078 2 0.026
single organism nuclear import GO:1902593 95 0.026
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.026
synaptic transmission GO:0007268 329 0.026
regulation of intracellular transport GO:0032386 159 0.026
regulation of multi organism process GO:0043900 111 0.026
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.026
regulation of histone modification GO:0031056 56 0.026
spindle assembly involved in mitosis GO:0090307 4 0.025
positive regulation of hydrolase activity GO:0051345 148 0.025
circadian rhythm GO:0007623 114 0.025
cell type specific apoptotic process GO:0097285 268 0.025
axonogenesis GO:0007409 274 0.025
cell division GO:0051301 120 0.025
gtp catabolic process GO:0006184 143 0.025
peptidyl lysine methylation GO:0018022 29 0.025
cellular ketone metabolic process GO:0042180 84 0.024
response to lipopolysaccharide GO:0032496 128 0.024
positive regulation of protein phosphorylation GO:0001934 242 0.023
regulation of ras protein signal transduction GO:0046578 114 0.023
digestive system development GO:0055123 200 0.023
purine nucleoside monophosphate catabolic process GO:0009128 58 0.023
hindbrain development GO:0030902 128 0.023
regulation of synapse structural plasticity GO:0051823 4 0.023
positive regulation of cell development GO:0010720 237 0.022
amine metabolic process GO:0009308 45 0.022
regulation of intracellular protein transport GO:0033157 82 0.022
protein targeting GO:0006605 143 0.022
actin cytoskeleton organization GO:0030036 220 0.022
regulation of ras gtpase activity GO:0032318 88 0.022
positive regulation of nucleotide metabolic process GO:0045981 114 0.022
positive regulation of cell activation GO:0050867 158 0.021
regulation of mrna processing GO:0050684 41 0.021
rna interference GO:0016246 2 0.021
viral process GO:0016032 41 0.021
dna repair GO:0006281 107 0.021
regulation of protein stability GO:0031647 52 0.021
regulation of gtp catabolic process GO:0033124 113 0.021
digestive tract development GO:0048565 190 0.021
mitotic cytokinesis GO:0000281 4 0.021
positive regulation of mapk cascade GO:0043410 170 0.021
hepaticobiliary system development GO:0061008 67 0.021
rna splicing GO:0008380 54 0.020
regulation of purine nucleotide catabolic process GO:0033121 122 0.020
cellular response to oxidative stress GO:0034599 76 0.020
embryonic digestive tract development GO:0048566 27 0.020
viral gene expression GO:0019080 3 0.020
regulation of establishment of protein localization GO:0070201 181 0.020
liver development GO:0001889 66 0.020
negative regulation of organelle organization GO:0010639 90 0.020
mrna metabolic process GO:0016071 84 0.020
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.019
regulation of protein localization GO:0032880 231 0.019
axon guidance GO:0007411 141 0.019
segmentation GO:0035282 93 0.019
regulation of cytoplasmic transport GO:1903649 112 0.019
regulation of nucleocytoplasmic transport GO:0046822 73 0.019
regulation of cellular amine metabolic process GO:0033238 20 0.019
dna recombination GO:0006310 92 0.019
guanosine containing compound catabolic process GO:1901069 144 0.019
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.019
nuclear import GO:0051170 95 0.018
regulation of cellular catabolic process GO:0031329 242 0.018
muscle cell differentiation GO:0042692 261 0.018
positive regulation of apoptotic process GO:0043065 217 0.018
negative regulation of cellular protein metabolic process GO:0032269 247 0.018
regulation of protein transport GO:0051223 163 0.018
posttranscriptional gene silencing GO:0016441 10 0.018
glycerolipid metabolic process GO:0046486 122 0.018
establishment of protein localization to organelle GO:0072594 118 0.018
nuclear division GO:0000280 158 0.018
nucleoside monophosphate metabolic process GO:0009123 85 0.018
lipid biosynthetic process GO:0008610 179 0.017
carbohydrate derivative biosynthetic process GO:1901137 183 0.017
histone ubiquitination GO:0016574 10 0.017
development of primary sexual characteristics GO:0045137 143 0.017
cellular homeostasis GO:0019725 240 0.017
regulation of mrna splicing via spliceosome GO:0048024 32 0.017
metencephalon development GO:0022037 89 0.017
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.017
regulation of nucleotide metabolic process GO:0006140 169 0.017
dendrite self avoidance GO:0070593 2 0.017
ventral midline development GO:0007418 4 0.017
innate immune response GO:0045087 157 0.017
purine ribonucleoside monophosphate catabolic process GO:0009169 57 0.017
interspecies interaction between organisms GO:0044419 83 0.017
cellular protein complex assembly GO:0043623 116 0.017
forebrain development GO:0030900 302 0.017
negative regulation of chromatin modification GO:1903309 19 0.016
intracellular receptor signaling pathway GO:0030522 74 0.016
regulation of purine nucleotide metabolic process GO:1900542 169 0.016
nucleoside monophosphate catabolic process GO:0009125 59 0.016
regulation of cell growth GO:0001558 91 0.016
response to extracellular stimulus GO:0009991 127 0.016
regulation of kinase activity GO:0043549 249 0.016
negative regulation of fibroblast proliferation GO:0048147 14 0.016
actin filament organization GO:0007015 113 0.016
regulation of vesicle mediated transport GO:0060627 139 0.016
peptidyl lysine modification GO:0018205 77 0.016
microtubule based movement GO:0007018 84 0.016
regulation of nucleotide catabolic process GO:0030811 122 0.016
regulation of rna splicing GO:0043484 37 0.016
regulation of cell cycle g1 s phase transition GO:1902806 35 0.016
neuron death GO:0070997 154 0.015
regulation of hormone levels GO:0010817 211 0.015
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.015
positive regulation of nucleoside metabolic process GO:0045979 91 0.015
gliogenesis GO:0042063 141 0.015
placenta development GO:0001890 140 0.015
protein import into nucleus GO:0006606 95 0.015
regulation of map kinase activity GO:0043405 120 0.015
regulation of protein targeting GO:1903533 61 0.015
regulation of cell projection organization GO:0031344 206 0.015
engulfment of apoptotic cell GO:0043652 3 0.015
negative regulation of histone h3 k9 methylation GO:0051573 4 0.014
viral life cycle GO:0019058 36 0.014
neural tube development GO:0021915 160 0.014
atp metabolic process GO:0046034 75 0.014
organelle localization GO:0051640 179 0.014
nitrogen compound transport GO:0071705 271 0.014
negative regulation of synapse assembly GO:0051964 3 0.014
regionalization GO:0003002 337 0.014
negative regulation of apoptotic signaling pathway GO:2001234 104 0.014
spleen development GO:0048536 39 0.014
dna alkylation GO:0006305 43 0.014
microtubule cytoskeleton organization involved in mitosis GO:1902850 4 0.014
cell fate commitment GO:0045165 210 0.014
compound eye development GO:0048749 1 0.014
adult behavior GO:0030534 135 0.014
positive regulation of histone h3 k4 methylation GO:0051571 5 0.014
neuron apoptotic process GO:0051402 142 0.014
positive regulation of protein transport GO:0051222 93 0.014
negative regulation of cell development GO:0010721 169 0.014
establishment or maintenance of actin cytoskeleton polarity GO:0030950 1 0.014
negative regulation of growth GO:0045926 99 0.014
cell growth GO:0016049 130 0.014
calcium mediated signaling GO:0019722 46 0.014
response to growth factor GO:0070848 198 0.014
ribonucleoside monophosphate metabolic process GO:0009161 80 0.013
regulation of cytokine production GO:0001817 266 0.013
regulation of protein import into nucleus GO:0042306 52 0.013
establishment or maintenance of cell polarity GO:0007163 86 0.013
response to nutrient levels GO:0031667 109 0.013
positive regulation of protein kinase activity GO:0045860 144 0.013
response to hydrogen peroxide GO:0042542 32 0.013
regulation of secretion GO:0051046 274 0.013
multicellular organism growth GO:0035264 161 0.013
locomotory behavior GO:0007626 195 0.013
embryonic organ morphogenesis GO:0048562 276 0.013
defense response to other organism GO:0098542 197 0.013
negative regulation of nervous system development GO:0051961 156 0.013
negative regulation of protein modification process GO:0031400 163 0.013
response to acid chemical GO:0001101 111 0.013
response to oxidative stress GO:0006979 123 0.013
regulation of lymphocyte activation GO:0051249 240 0.013
negative regulation of cell cycle phase transition GO:1901988 48 0.013
negative regulation of intracellular signal transduction GO:1902532 167 0.013
regulation of secretion by cell GO:1903530 249 0.013
cleavage involved in rrna processing GO:0000469 1 0.013
small molecule biosynthetic process GO:0044283 132 0.013
purine nucleoside monophosphate metabolic process GO:0009126 81 0.013
mrna transport GO:0051028 13 0.012
endomembrane system organization GO:0010256 147 0.012
internal protein amino acid acetylation GO:0006475 42 0.012
organelle fission GO:0048285 170 0.012
regulation of actin filament based process GO:0032970 99 0.012
positive regulation of intracellular transport GO:0032388 70 0.012
localization within membrane GO:0051668 4 0.012
negative regulation of chromatin silencing GO:0031936 1 0.012
atp catabolic process GO:0006200 55 0.012
protein modification by small protein conjugation GO:0032446 187 0.012
regulation of skeletal muscle contraction GO:0014819 3 0.012
histone acetylation GO:0016573 41 0.012
protein autophosphorylation GO:0046777 61 0.012
maintenance of protein localization in organelle GO:0072595 2 0.012
cellular metal ion homeostasis GO:0006875 151 0.012
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.012
regulation of striated muscle contraction GO:0006942 25 0.012
reactive oxygen species metabolic process GO:0072593 84 0.012
cellular component assembly involved in morphogenesis GO:0010927 139 0.012
regulation of hydrolase activity GO:0051336 246 0.012
regulation of system process GO:0044057 200 0.012
positive regulation of cellular catabolic process GO:0031331 148 0.012
nucleus localization GO:0051647 20 0.012
rna 5 end processing GO:0000966 1 0.012
cellular chemical homeostasis GO:0055082 215 0.012
rna processing GO:0006396 105 0.012
calcium ion homeostasis GO:0055074 127 0.012
spermatid differentiation GO:0048515 115 0.012
response to organic cyclic compound GO:0014070 198 0.011
chromatin assembly GO:0031497 13 0.011
lateral inhibition GO:0046331 1 0.011
protein polymerization GO:0051258 57 0.011
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.011
regulation of t cell proliferation GO:0042129 92 0.011
protein localization to chromosome GO:0034502 6 0.011
cation transport GO:0006812 399 0.011
dna templated transcription termination GO:0006353 4 0.011
protein acylation GO:0043543 64 0.011
cognition GO:0050890 149 0.011
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.011
cellular protein catabolic process GO:0044257 155 0.011
positive regulation of protein import into nucleus GO:0042307 26 0.011
regulation of protein complex assembly GO:0043254 83 0.011
positive regulation of cell death GO:0010942 224 0.011
chromosome organization involved in meiosis GO:0070192 39 0.011
viral transcription GO:0019083 3 0.011
t cell activation GO:0042110 289 0.011
monocarboxylic acid metabolic process GO:0032787 191 0.011
regulation of homeostatic process GO:0032844 182 0.011
negative regulation of cellular amine metabolic process GO:0033239 1 0.011
neuron migration GO:0001764 122 0.011
nucleobase containing compound transport GO:0015931 27 0.011
organic hydroxy compound metabolic process GO:1901615 203 0.011
dna methylation involved in gamete generation GO:0043046 15 0.011
pore complex assembly GO:0046931 3 0.011
endonucleolytic cleavage of tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna GO:0000479 1 0.011
translation GO:0006412 93 0.011
thymus development GO:0048538 41 0.011
cell recognition GO:0008037 83 0.010
regulation of cell cycle process GO:0010564 160 0.010
regeneration GO:0031099 38 0.010
mitotic sister chromatid segregation GO:0000070 14 0.010
response to molecule of bacterial origin GO:0002237 143 0.010
regulation of proteolysis GO:0030162 164 0.010
spermatid development GO:0007286 108 0.010
regulation of clathrin mediated endocytosis GO:2000369 4 0.010
negative regulation of striated muscle cell differentiation GO:0051154 14 0.010
gonad development GO:0008406 141 0.010
mitotic cell cycle GO:0000278 195 0.010
negative regulation of dna replication GO:0008156 4 0.010
symbiosis encompassing mutualism through parasitism GO:0044403 83 0.010
positive regulation of cytokine production GO:0001819 174 0.010
regulation of protein localization to nucleus GO:1900180 60 0.010
divalent inorganic cation homeostasis GO:0072507 138 0.010
cilium assembly GO:0042384 81 0.010
retrograde transport endosome to golgi GO:0042147 2 0.010
myosin filament organization GO:0031033 3 0.010
ribonucleoside monophosphate catabolic process GO:0009158 57 0.010
regulation of cell cycle phase transition GO:1901987 77 0.010
protein processing GO:0016485 163 0.010

Setx disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
nervous system disease DOID:863 0 0.040
disease of anatomical entity DOID:7 0 0.040
central nervous system disease DOID:331 0 0.024
physical disorder DOID:0080015 0 0.011
neurodegenerative disease DOID:1289 0 0.011
neuropathy DOID:870 0 0.010